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colorectal cancer: fusobacterium nucleatum found in colon cancer tissue--could an infection cause colorectal cancer? 201122083120
Quantitative analysis of microbiota in saliva, supragingival, and subgingival plaque of Chinese adults with chronic periodontitis.OBJECTIVE: The aim of this study was to determine the profiles of periodontopathogenic bacteria in a Chinese population using quantitative real-time polymerase chain reaction (qRT-PCR). MATERIALS AND METHODS: Twenty-four periodontally healthy Chinese subjects and 60 patients with chronic periodontitis (CP) were enrolled in this cross-sectional study. qRT-PCR was used to quantify Aggregatibacter actinomycetemcomit ...201122169888
Isoflavonoids and Coumarins from Glycyrrhiza uralensis: Antibacterial Activity against Oral Pathogens and Conversion of Isoflavans into Isoflavan-Quinones during Purification.Phytochemical investigation of a supercritical fluid extract of Glycyrrhiza uralensis has led to the isolation of 20 known isoflavonoids and coumarins, and glycycarpan (7), a new pterocarpan. The presence of two isoflavan-quinones, licoriquinone A (8) and licoriquinone B (9), in a fraction subjected to gel filtration on Sephadex LH-20 is due to suspected metal-catalyzed oxidative degradation of licoricidin (1) and licorisoflavan A (2). The major compounds in the extract, as well as 8, were evalu ...201122074222
fusobacterium nucleatum adhesin fada binds vascular endothelial cadherin and alters endothelial integrity.fusobacterium nucleatum is a gram-negative oral anaerobe, capable of systemic dissemination causing infections and abscesses, often in mixed-species, at different body sites. we have shown previously that f. nucleatum adheres to and invades host epithelial and endothelial cells via a novel fada adhesin. in this study, vascular endothelial (ve)-cadherin, a member of the cadherin family and a cell-cell junction molecule, was identified as the endothelial receptor for fada, required for f. nucleatu ...201122040113
antibacterial effects of chemomechanical instrumentation and calcium hydroxide in primary teeth with pulp necrosis.this study's purposes were to: evaluate the antibacterial effect of chemomechanical instrumentation and a calcium hydroxide-based dressing in primary teeth with pulp necrosis secondary to trauma; and detect the presence of fusobacterium nucleatum and black-pigmented rods in the canals of these teeth.201121902996
Levels of periodontal pathogens in neonatal gastric aspirates and possible maternal sites of origin.Maternal periodontal infection has been recognized as a risk factor for preterm and low birthweight infants. It is suspected that pathogens causing periodontal disease may translocate to the amniotic cavity and so contribute to triggering an adverse pregnancy outcome. This study aimed to determine levels and proportions of periodontal bacteria in neonatal gastric aspirates obtained from complicated pregnancies and the respective maternal oral and vaginal samples using a quantitative polymerase c ...201121896155
fusobacterium nucleatum prosthetic hip infection in an adult with sickle cell-beta thalassemia.fusobacterium nucleatum is an anaerobic gram-negative bacillus commensal to the human oropharynx and gastrointestinal tract which causes an array of human infection, yet it has never been associated with infection of prosthetic joints. we report the first case of prosthetic hip infection caused by f. nucleatum in a man with sickle cell-beta thalassemia.201122002730
Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential.Isoliquiritigenin (1) and liquiritigenin (2) are structurally related flavonoids found in a variety of plants. The purpose of this study was to perform a comparative analysis of biological properties of these compounds in regard to their therapeutic potential for oral infections. Compound 1 demonstrated significant antibacterial activity against three major periodontopathogens, Porphyromonas gingivalis, Fusobacterium nucleatum, and Prevotella intermedia. In contrast, 2 exerted less pronounced ef ...201121866899
Microbiological analysis of gingivitis in pediatric patients under orthodontic treatment.The aim of this study was to determine the relationship between gingival inflammation and changes in bacteria of the gingival sulcus in children in orthodontic treatment with brackets.201122185242
synergy in biofilm formation between fusobacterium nucleatum and prevotella species.the formation of biofilm by anaerobic, gram-negative bacteria in the subgingival crevice plays an important role in the development of chronic periodontitis. the aim of this study was to characterize the role of coaggregation between fusobacterium nucleatum and prevotella species in biofilm formation. coaggregation between f. nucleatum and prevotella species was determined by visual assay. effect of co-culture of the species on biofilm formation was assessed by crystal violet staining. effect of ...201121945879
analysis of symptomatic and asymptomatic primary root canal infections in adult norwegian patients.this molecular study analyzed the microbiota of primary root canal infections from adult norwegian patients.201121846535
extracellular deoxyribonuclease production by periodontal bacteria.palmer lj, chapple ilc, wright hj, roberts a, cooper pr. extracellular deoxyribonuclease production by periodontal bacteria. j periodont res 2011; doi: 10.1111/j.1600-0765.2011.01451.x © 2011 john wiley & sons a/s background and objective:  whilst certain bacteria have long been known to secrete extracellular deoxyribonuclease (dnase), the purpose in microbial physiology was unclear. recently, however, this enzyme has been demonstrated to confer enhanced virulence, enabling bacteria to evade the ...201122150619
isolation and molecular identification of fusobacterium nucleatum from nigerian patients with oro-facial infections.fusobacterium nucleatum is one of the most common anaerobic bacteria present in the oral cavity and is often isolated from infections involving other body sites.201121984462
longitudinal and cross-sectional assessments of age changes in physical strength as related to sex, social class, and mental ability. 20114833758
limited in-depth invasion of fusobacterium nucleatum into in vitro reconstructed human gingiva.objective: fusobacterium nucleatum is an opportunistic pathogen with a key role in subgingival plaque formation and it is found in increased numbers in periodontally affected sites. this study aimed to investigate the potential of f. nucleatum to penetrate and induce alterations in an in vitro reconstructed human gingival mucosa model. methods: three-dimensional (3d) organotypic models of human gingiva were engineered using primary gingival keratinocytes and fibroblasts. the reconstructed tissue ...201122024403
The comparative evaluation of xanthan gel with chlorhexidine (Chlosite) in smokers and non-smokers: A clinical and microbiological assessment.Prevention of the periodontal disease progression is the primary goal of periodontal therapy. When conventional therapy is found inadequate to attain periodontal health in chronic periodontitis, local antimicrobial agents have been used as an adjunct with scaling and root planning (SRP) which has reproduced encouraging results. Hence, this study was undertaken to evaluate the new sustained released local drug Chlosite clinically and microbiologically in smokers and non-smokers.201122028508
internal decompressive craniectomy with craniotomy: a novel surgical therapy of giant frontal mucocele complicated by subdural empyema.giant frontal mucocele (gfm) is an extremely rare cause of frontal lobe syndrome. subdural empyema (sde) is an uncommon complication of paranasal sinisutis, for which craniotomy and decompressive craniotomy are the most effective surgical procedures.201122368985
colonisation of the oral cavity by periodontopathic bacteria in complete denture wearers.gerodontology 2011; doi: 10.1111/j.1741-2358.2011.00506.x colonisation of the oral cavity by periodontopathic bacteria in complete denture wearers objective:  the purpose of this study was to investigate colonisation by periodontopathic bacteria and the sites of colonisation in elderly upper and lower complete denture wearers. we also investigated the relationship between level of oral hygiene and colonisation by periodontopathic bacteria. materials and methods:  forty edentulous and 37 dentate ...201121929616
Oral Bacterial DNA Differ in Their Ability to Induce Inflammatory Responses in Human Monocytic Cell Lines.BACKGROUND: DNA of periodontal pathogens, Porphyromonas gingivalis (Pg-DNA) and Tannerella forsythia, stimulate cytokine production in human monocytic cells (THP-1) through Toll like receptor 9 (TLR-9) and nuclear factor kappa B signaling. Fusobacterium nucleatum is one of the most frequently isolated bacteria in periodontally-diseased tissues and reported to synergize with Porhyromonas gingivalis enhancing the pathogenicity. We investigated inflammatory mediator production in THP-1 cells challe ...201122166166
deficiency of eosinophil peroxidase detected by automated cytochemistry. 20113122494
clinical experience with the use of charcoal haemoperfusion: is prostacyclin required?twenty patients have undergone a total of 47 charcoal haemoperfusions without the use of prostacyclin. a fall in platelet numbers and evidence of platelet activation have been found during haemoperfusion but few clinical complications have been observed. therefore, we believe that the clinical value of the addition of prostacyclin during charcoal haemoperfusion has not been proven. nevertheless, its apparent protective effect on platelet numbers and activation indicates that further controlled t ...20113894813
retreatodontics and ultrasonics. 20113162934
the conus with no great artery.in three patients with complex cyanotic congenital heart disease, the conus was found to have no arterial outlet. the semilunar valves were at similar, caudad levels, and there was malposition of the great arteries. the aorta was related to the body--not the outflow portion--of the right ventricle in two patients with transposition and to the body of the left ventricle in one child with single ventricle. these cases confirm the independent embryological segregation of the conus and the truncus. ...20113207481
proceedings from a workshop symposium of the 14th international congress of chemotherapy. kyoto, japan, june 23-28, 1985. 20123510504
[surgical treatment of primary chronic pancreatitis].surgical methods of treatment of chronic alcoholic pancreatitis must be chosen with special reference to the state of the duct and parenchyma of the pancreas. treatment of alcoholic patients should be performed with the participation of psychiatrists.20123424549
synergistic effect on biofilm formation between fusobacterium nucleatum and capnocytophaga ochracea.the formation of dental plaque biofilm by specific gram-negative rods and spirochetes plays an important role in the development of periodontal disease. the aim of this study was to characterize biofilm formation by fusobacterium nucleatum and capnocytophaga ochracea. coaggregation between f. nucleatum and capnocytophaga species was determined by visual assay. biofilm formation was assessed by crystal violet staining. enhancement of biofilm formation by f. nucleatum via soluble factor of c. ochr ...201222252100
[subcutaneous rupture of tendons and muscles of the extremities].under study there were 278 patients with 285 subcutaneous ruptures of tendons and muscles of the upper and lower extremities. the tendon of the long head of the humeral biceps muscle and achilles tendon are most liable to subcutaneous ruptures (123 patients--43.2% and 97 patients--34% respectively). pathohistological examinations have shown that subcutaneous ruptures of tendons and muscles usually take place against the background of dystrophic alterations reducing their mechanical strength. the ...20123303625
necrotizing periodontal diseases in hiv-infected brazilian patients: a clinical and microbiologic descriptive study.objective: nowadays, necrotizing periodontal diseases have a low prevalence; however, a better understanding of the etiopathogenesis of these diseases is necessary for determining more adequate preventive and therapeutic strategies. method and materials: from a pool of 1,232 hiv-infected patients, 15 presented with necrotizing periodontal diseases, which were evaluated by full-mouth periodontal clinical measurements. subgingival biofilm samples were collected from necrotizing lesions of six of t ...201222259811
cancer, stress and personality: a correlational investigation of life-events, repression-sensitization and locus of control.this study investigated the hypothesis that stress-inducing life experiences and the personality factors of external locus of control and tendency to repress emotion are relevant in the aetiology of cancer. fifty cancer patients scored higher than 50 matched controls on a life-events scale (especially negative events), but were found to be lower on repression of emotion. there was no difference between groups on locus of control.20123401426
fusobacterium nucleatum biofilm induces epithelial migration in an organotypic model of dento-gingival junction.background: effects of fusobacterium nucleatum biofilm on epithelial cell proliferation, apoptotic cell death and basement membrane constituent collagen iv production were examined in an organotypic dento-epithelial (od-e) model. methods: the od-e model was constructed by seeding keratinocytes on fibroblast-containing collagen gels and by placing tooth pieces on the top. a 3-day-old biofilm of either a laboratory strain (atcc 25586) or a clinical strain (ahn 9508) of f. nucleatum was placed on ...201222248219
initiation of blood coagulation at artificial surfaces. 20123439730
evaluation of periodontal pathogens in amniotic fluid and the role of periodontal disease in pre-term birth and low birth weight.pre-term birth and/or low birth weight (ptlbw) is a serious problem in developing countries. the absence of known risk factors in ≈ 50% of ptlbw cases has resulted in a continued search for other causes. the aim of this study was to examine the effect of periodontitis on pregnancy outcomes.201223638858
Signal peptide of FadA adhesin from Fusobacterium nucleatum plays a novel structural role by modulating the filament's length and width.FadA, a novel adhesin of periodontal pathogen Fusobacterium nucleatum is composed of two forms, pre-FadA and mature FadA (mFadA), constituting the functional FadA complex (FadAc). By electron microscopy, we observed that mFadA formed uniformly long and thin filaments, while FadAc formed heterogeneous filaments of varying lengths and widths, as well as "knots". Mutants in signal peptide or in the non-alpha-helical loop retaining heterogeneous structures had binding activity while those forming ag ...201222108653
variations in the oral anaerobic microbial flora in relation to pregnancy.pregnancy gingivitis is a major oral infection. periodontium acts as a reservoir of inflammatory mediators and sub gingival biofilms of bacteria.201223285437
validation of a quantitative real-time pcr assay and comparison with fluorescence microscopy and selective agar plate counting for species-specific quantification of an in vitro subgingival biofilm model.subgingival biofilms are the prime etiological factor of periodontal disease. owing to their complex polymicrobial nature, quantification of individual bacterial species within the biofilm for research and diagnostic purposes can be methodologically challenging. the aims of this study were to establish a quantitative real-time pcr (qpcr) assay to quantify the bacteria used in our 10-species in vitro 'subgingival' biofilm model and to compare the quantitative outcome with fluorescence microscopy ...201223278531
antibacterial activity of essential oils against periodontal pathogens: a qualitative systematic review.periodontal diseases are among the most common infectious diseases that lead to the destruction of periodontal tissues. anaerobic gram-negative bacteria (aggregatibacter actinomecetemcomitans, porphyromonas gingivalis, fusobacterium nucleatum...) isolated from periodontal lesions, have been shown to be related to the onset and progression of periodontal disease. given the incidence of periodontitis, increased resistance of oral bacteria to antibiotics and adverse effects of some antibacterial ag ...201223513511
microbiology of the gut of the kola nut weevil, balanogastris kolae.reports have shown that many insects have microbes in their gut system. gut microbes are very important for insect vitality and much of their nutrition is derived from products of microbial metabolism. the habitat of balanogastris kolae (desbrocher des loges) (coleoptera: curculionidae) suggests that they possess the ability to digest varieties of sugars particularly starch and protein materials present in the kola nut, cola nitida schott & endlicher (malvales: malvaceae). the aim of this study ...201223421598
[expression of cytokines in dentogingival sulcus in patients after dental implantation and during development of peri-implantitis].determination of cytokine content in various areas of dentition in patients with peri-implantitis associated with parodontopathogenic bacteria species of i and ii order.201223297645
oral microbial biofilm stimulation of epithelial cell responses.oral bacterial biofilms trigger chronic inflammatory responses in the host that can result in the tissue destructive events of periodontitis. however, the characteristics of the capacity of specific host cell types to respond to these biofilms remain ill-defined. this report describes the use of a novel model of bacterial biofilms to stimulate oral epithelial cells and profile select cytokines and chemokines that contribute to the local inflammatory environment in the periodontium. monoinfection ...201222266273
microbial profile of patients with periodontitis compared with healthy subjects.objective: to define and compare the microbiologic profile of subgingival plaque in german patients with periodontitis (including aggressive and advanced chronic periodontitis) and healthy subjects and to determine significant association between isolates and clinical status. aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, and tannerella forsythia are major periodontal pathogens, though it is recognized that other species may also contribute to the pathogenesis of periodontal di ...201222257880
in vitro antibacterial activity of galls of quercus infectoria olivier against oral pathogens.the galls of quercus infectoria are commonly used in malay traditional medicine to treat wound infections after childbirth. in india, they are employed traditionally as dental applications such as that in treatment of toothache and gingivitis. the aim of the present study was to evaluate the antibacterial activity of galls of quercus infectoria olivier against oral bacteria which are known to cause dental caries and periodontitis. methanol and acetone extracts were screened against two gram-posi ...201222203875
salivary β-galactosidase activity affects physiological oral malodour.previous reports have associated salivary β-galactosidase activity with non-periodontopathic oral malodour. in this study, we investigated the localization of β-galactosidase and elucidated the relationship between its enzymatic activity and physiological oral malodour.201221885033
detection of fusobacterium nucleatum in chorionic tissues of high-risk pregnant women.this study was undertaken to investigate the existence of a periodontopathic bacterium, fusobacterium nucleatum, in chorionic tissues of pregnant women, and the effects of f. nucleatum on human chorion-derived cells.201222304677
cytokine expression in response to root canal infection in gnotobiotic mice.to examine cytokine expression profiles during periapical lesion development in response to synergetic human pathogens in a gnotobiotic mouse model.201222233143
butyric acid induces apoptosis in both human monocytes and lymphocytes equivalently.short-chain fatty acids (scfas) are metabolites from anaerobic periodontopathic bacteria that induce apoptosis in immune cells such as lymphocytes, monocytes and macrophages. however, it remains unclear if scfas from pathogens induce apoptosis in monocytes/macrophages similarly with lymphocytes. this study investigated whether scfas-induced apoptosis is equal among the immunoregulatory cells. cell apoptosis of the employed human cells was evaluated after treatment with culture supernatants from ...201222466881
direct recognition of fusobacterium nucleatum by the nk cell natural cytotoxicity receptor nkp46 aggravates periodontal disease.periodontitis is a common human chronic inflammatory disease that results in the destruction of the tooth attachment apparatus and tooth loss. although infections with periopathogenic bacteria such as porphyromonas gingivalis (p. gingivalis) and fusobacterium nucleatum (f. nucleatum) are essential for inducing periodontitis, the nature and magnitude of the disease is determined by the host's immune response. here, we investigate the role played by the nk killer receptor nkp46 (ncr1 in mice), in ...201222457623
giant frontal mucocele complicated by subdural empyema: treatment of a rare association.giant frontal mucocele (gfm) is an extremely rare cause of frontal lobe syndrome. subdural empyema (sde) is an uncommon complication of paranasal sinisutis, for which craniotomy and decompressive craniotomy are the most effective surgical procedures. a 54-year-old man was brought unconscious to the emergency room where recurrent generalized seizures occurred. heroine abuse, hcv-related hepatitis, prolonged antibiotic therapy for treatment of purulent rhinorrhea, along with recent personality cha ...201222427297
identification of oral bacterial dna in synovial fluid of patients with arthritis with native and failed prosthetic joints.we examined the presence of bacterial dna in synovial fluids of native or clinically aseptically failed prosthetic joints from patients having periodontal disease and arthritis to determine whether there is bacterial spread from the oral cavity to the joints.201222426587
draft genome sequence of fusobacterium nucleatum chdc f128, isolated from a periodontitis lesion.fusobacterium nucleatum is classified into five subspecies. f. nucleatum chdc f128 was isolated from a periodontitis lesion and proposed as a new subspecies based on the comparison of the nucleotide sequences of the rna polymerase beta subunit and zinc protease genes. here, we report the draft genome sequence of the strain.201223105064
inflammatory index and treatment of brain abscess.this study retrospectively analyzed 12 patients with brain abscesses. half of the patients were diagnosed inaccurately in the initial stage, and 7.2 days were required to achieve the final diagnosis of brain abscess. the patients presented only with a moderately elevated leukocyte count, serum crp levels, or body temperatures during the initial stage. these markers changed, first with an increase in the leukocyte count, followed by the crp and body temperature. the degree of elevation tended to ...201223092104
antibacterial activity of calcium hydroxide and chlorhexidine containing points against fusobacterium nucleatum and parvimonas micra.up to 90% of the flora of an infected root canal consists of obligate anaerobic bacteria. however, most studies have centred on microaerophiles. this quantitative assay investigated the antibacterial effects against fusobacterium nucleatum and parvimonas micra of gutta-percha (gp) points containing either calcium hydroxide (ca(oh)(2)) or chlorhexidine (chx) compared to those of conventional gp points.201223077425
microscope-based imaging platform for large-scale analysis of oral biofilms.a microscopic method for noninvasively monitoring oral biofilms at the macroscale was developed to describe the spatial distribution of biofilms of different bacterial composition on bovine enamel surfaces (bes). for this purpose, oral biofilm was grown in situ on bes that were fixed at approximal sites of individual upper jaw acrylic devices worn by a volunteer for 3 or 5 days. eubacteria, streptococcus spp., and fusobacterium nucleatum were stained using specific fluorescence in situ hybridiza ...201223042171
draft genome sequence of fusobacterium nucleatum subsp. fusiforme atcc 51190t.fusobacterium nucleatum, one of the major causative bacteria of periodontitis, is classified into five subspecies (nucleatum, polymorphum, vincentii, animalis, and fusiforme) on the basis of the several phenotypic characteristics and dna homology. this is the first report of the draft genome sequence of f. nucleatum subsp. fusiforme atcc 51190(t).201222965077
morphological, biochemical, physiological and molecular aspects of the response of fusobacterium nucleatum exposed to subinhibitory concentrations of antimicrobials.subinhibitory concentrations (sics) of antimicrobials may result in alterations in bacterial biology with implications for its potential aggression. this has considerable importance for the resident microbiota. our aim was to analyze the effects of sics of antimicrobials on the morphological, biochemical, physiological and molecular characteristics of the resident anaerobic fusobacterium nucleatum. fourteen strains were obtained from f. nucleatum atcc 25586, selected by culturing on sics of ampi ...201223023263
proteomics of streptococcus gordonii within a model developing oral microbial community.streptococcus gordonii is one of several species that can initiate the formation of oral biofilms that develop into the complex multispecies microbial communities referred to as dental plaque. it is in the context of dental plaque that periodontal pathogens such as porphyromonas gingivalis cause disease. we have previously reported a whole cell quantitative proteomics investigation of p. gingivalis in a model dental plaque community of s. gordonii, p. gingivalis, and fusobacterium nucleatum. her ...201222989070
isothermal microcalorimetry provides new insights into biofilm variability and dynamics.the purpose of this study was to investigate a three-species in vitro biofilm with peri-implantitis-related bacteria for its variability and metabolic activity. streptococcus sanguinis, fusobacterium nucleatum, and porphyromonas gingivalis were suspended in simulated body fluid containing 0.2% glucose to form biofilms on polished, protein-coated implant-grade titanium disks over 72 h using a flow chamber system. thereafter, biofilm-coated disks were characterized by scanning electron microscopy ...201222967269
high-fat diet induces periodontitis in mice through lipopolysaccharides (lps) receptor signaling: protective action of estrogens.a fat-enriched diet favors the development of gram negative bacteria in the intestine which is linked to the occurrence of type 2 diabetes (t2d). interestingly, some pathogenic gram negative bacteria are commonly associated with the development of periodontitis which, like t2d, is characterized by a chronic low-grade inflammation. moreover, estrogens have been shown to regulate glucose homeostasis via an lps receptor dependent immune-modulation. in this study, we evaluated whether diet-induced m ...201223133617
acute chorioamnionitis at term caused by the oral pathogen fusobacterium nucleatum.fusobacterium nucleatum is an oral pathogen associated with preterm birth. presented is a case of acute chorioamnionitis that progressed to maternal sepsis in a term patient with intact membranes. in addition to its role in periodontal disease and preterm birth, our case demonstrates that intrauterine infection with fusobacterium nucleatum can result in severe disease at term.201223115747
fusobacterium nucleatum infection mimicking metastatic cancer.a 48-year-old man presented with fevers, chills, weight loss, multiple liver masses, and several superficial and deep venous thromboses in lower extremities. cancer work up was negative. a liver biopsy grew fusobacterium nucleatum. to our knowledge, f. nucleatum infection presenting with multiple liver masses and trousseau-like syndrome has not been reported earlier.201222875742
comparison of endotoxin levels found in primary and secondary endodontic infections.this clinical study was conducted to compare the levels of endotoxins (lipopolysaccharides [lpss]) found in primary and secondary endodontic infections with apical periodontitis by correlating lps contents with clinical/radiographic findings. in addition, the presence of target gram-negative anaerobic bacteria was also investigated.201222794210
effectiveness of egg yolk immunoglobulin (igy) against periodontal disease-causing fusobacterium nucleatum.to evaluate the in vitro and in vivo effectiveness of egg yolk immunoglobulin (igy) against periodontal disease-causing fusobacterium nucleatum.201222789022
peritonsillar abscess: treatment with immediate tonsillectomy - 10 years of experience.immediate tonsillectomy in patients with peritonsillar abscess is a safe and effective treatment that should be considered as an alternative to conventional incision and drainage.201222708633
gene-diet interactions on colorectal cancer risk.there has been increasing interest lately in understanding how natural dietary antioxidants affect chemoprevention, and recently, there has been a merging of information about antioxidants, endogenous and exogenous reactive oxygen and nitrogen species (rons), and inflammation. rons normally serve the cells as second messengers to regulate many of the intracellular signaling cascades that govern multiple cellular activities. however, when the amount of rons exceeds the cell's ability to metaboliz ...201224392268
effect of s-prg eluate on biofilm formation and enzyme activity of oral bacteria.recently, the antibacterial activity of a composite resin containing prereacted glass ionomer (s-prg) filler was revealed. we examined the effect of an s-prg eluate on various biologic activities of streptococcus mutans and porphyromonas gingivalis. adherence ability of s. mutans was evaluated by microtiter plate assay; protease and gelatinase activities of p. gingivalis were examined by synthetic substrate hydrolysis and gelatin film spot assay, respectively. coaggregation of p. gingivalis with ...201222693508
pulmonary botryomycosis on a lung cavity: a rare pulmonary infection mimicking cancer.lung botryomycosis is a rare disease. we report what is to our knowledge the first case occurring on a lung cavity. in a 42-year-old man suffering asthenia and cough, a chest radiograph revealed a right upper lobe opacity. computed tomography scan showed a necrotic mass which was also spiculated. repeated research for mycobacterium tuberculosis was negative. the patient underwent a lobectomy. histological and bacteriological examinations made the diagnosis of botryomycosis, because the cavity pr ...201222627958
the foma porin from fusobacterium nucleatum is a toll-like receptor 2 agonist with immune adjuvant activity.many bacterial components selectively activate immune and nonhematopoietic target cells via toll-like receptor (tlr) signaling; modulation of such host responses defines the immune adjuvant properties of these bacterial products. for example, the outer membrane protein porins from neisseria, salmonella, and shigella are known tlr2 agonists with established systemic and mucosal immune adjuvanticity. early work indicated that the foma porin from fusobacterium nucleatum has immune adjuvant activity ...201222623652
[impact of periodontal disease on arterial pressure in diabetic mice].diabetes-driven cardiovascular diseases represent a high challenge for developed countries. periodontal disease is strictly linked to the aforementioned diseases, due to its gram negative-driven inflammation. thus, we investigated the effects of periodontal disease on arterial pressure during the development of diabetes in mice. to this aim, c57bl/6 female mice were colonized with pathogens of periodontal tissue (porphyromonas gingivalis, prevotella intermedia and fusobacterium nucleatum) for 1m ...201222621847
occurrence and antimicrobial susceptibility of porphyromonas spp. and fusobacterium spp. in dogs with and without periodontitis.the occurrence of porphyromonas gulae, porphyromonas macacae, fusobacterium nucleatum and fusobacterium canifelinum in subgingival plaque from dogs with and without periodontitis as well as their antimicrobial susceptibility were evaluated. from 50 dogs with periodontitis were identified 38 p. gulae, 8 p. macacae, 26 f. nucleatum and 15 f. canifelinum, and from 50 dogs without periodontitis were identified 15 p. gulae, 12 f. nucleatum and 11 f. canifelinum. all strains were susceptible to most o ...201222609780
the role of coaggregation between porphyromonas gingivalis and fusobacterium nucleatum on the host response to mixed infection.to evaluate the role of coaggregation between porphyromonas gingivalis and fusobacterium nucleatum on the virulence of the mixed infection in mice.201222607053
septic arthritis and osteomyelitis in a 10-year-old boy, caused by fusobacterium nucleatum, diagnosed with pcr/16s ribosomal bacterial dna amplification.a 10-year-old boy presented with an atypical non-febrile septic arthritis/osteomyelitis. he was unresponsive to routine antibiotic treatment with flucloxacillin/gentamicin as the pain and fluid collection increased. synovial fluid cultures are negative and gram stain remained negative. only after pcr/16s ribosomal bacterial dna amplification a fusobacterium nucleatum could be detected, and antibiotic therapy switched to clindamycin with rapid response. septic osteomyelitis and arthritis are rela ...201222605875
purification, crystallization and preliminary x-ray analysis of two hydrogen sulfide-producing enzymes from fusobacterium nucleatum.hydrogen sulfide produced by oral bacteria is responsible for oral malodour. two homologous hydrogen sulfide-producing enzymes, fn1220 and cdl, from fusobacterium nucleatum (which actively produces hydrogen sulfide) were overproduced, purified and crystallized. x-ray diffraction data were collected from the crystals using a synchrotron-radiation source. the fn1220 crystal belonged to tetragonal space group p4(1)2(1)2 or p4(3)2(1)2 (unit-cell parameters a=b=116.8, c=99.2 å) and the cdl crystal be ...201223192034
effects of oil drops containing lactobacillus salivarius wb21 on periodontal health and oral microbiota producing volatile sulfur compounds.the objective of this paper is to evaluate the effects of oil drops containing lactobacillus salivarius wb21 on periodontal health and oral microbiota producing volatile sulfur compounds (vscs). for this study, 42 subjects were randomly assigned to receive oil samples containing l. salivarius wb21 or a placebo for two weeks. oral assessment and saliva collection were performed on days 1 and 15. bacterial analysis was performed using the real-time polymerase chain reaction and terminal restrictio ...201222368259
[fractures of the crowns of teeth and their treatment]. 20123482746
igg subclass antibodies in response to house dust mite immunotherapy.the data obtained so far indicate that house dust mite immunotherapy stimulates an igg antibody response that is predominantly of igg4 subclass. early in the course, however, a rise in igg1 antibodies can be detected, but as treatment goes on igg4 becomes more prominent. the association between the development of igg4 antibodies and objectively measured clinical improvements resulting from immunotherapy, strongly suggests that igg4 antibodies might exert a blocking effect on ige-mediated immedia ...20123481430
cellulitis associated with dermatophyte infection in the vein-donor-leg of a coronary artery bypass patient. 20123873016
the 1985 new jersey physician manpower supply. 20123474560
oral acyclovir in the treatment of acute herpes zoster ophthalmicus.seventy-one nonimmunocompromised patients with herpes zoster ophthalmicus, presenting within seven days of onset of characteristic skin eruption, were enrolled in a prospective, longitudinal, randomized, double-masked, placebo-controlled trial with oral acyclovir. in a previous interim report we noted more prompt resolution of dermatomal signs and symptoms with acyclovir treatment. there was also a reduction of viral shedding in acyclovir-treated patients coupled with a trend to greater rate of ...20123488532
advantages and limits of intravenous thrombolysis. 20123411614
failures to confirm the spatial-frequency hypothesis: fatal blow or healthy complication. 20123502907
[training dental technicians. 30. control baseplate]. 20123527777
a new nematode, yatinema japonicum gen. et sp. n. (heligmonellidae: nematoda), from voles, eothenomys smithi thomas and e. niigatae (anderson). 20123517440
[transcutaneous electrical nerve stimulation (tens) in obstetrics].labour pains have been influenced by tens (electrodes placed at th10 to l2) in 78 women (control group comprising 46 women) during delivery. no electrostimulation of the sacral segments was carried through. the two groups were comparable well because of similarities in their age, the babies' size at birth and equal conditions during delivery. the first tens effect observed was a marked reduction of duration of labour with no increase in pathological cardiotocographic findings. with tens applied, ...20123487901
endoscopic retrograde cholangiopancreatography findings of a gallbladder filling defect caused by sludge.ultrasound of the abdomen has described intraluminal gallbladder masses or stones without acoustic shadowing which have been termed "sludge balls." this finding has not been previously reported via its x-ray appearance at endoscopic retrograde cholangiopancreatography. this case reports this finding at endoscopic retrograde cholangiopancreatography and emphasizes that it is in the spectrum between suprasaturated bile and choledocholithiasis.20123548329
[abnormal visuovestibular interaction in congenital jerky nystagmus]. 20123486553
the guanine and cytosine content of genomic dna and bacterial evolution.the genomic guanine and cytosine (g + c) content of eubacteria is related to their phylogeny. the g + c content of various parts of the genome (protein genes, stable rna genes, and spacers) reveals a positive linear correlation with the g + c content of their genomic dna. however, the plotted correlation slopes differ among various parts of the genome or among the first, second, and third positions of the codons depending on their functional importance. facts suggest that biased mutation pressur ...20123467347
radiology in the management of impacted teeth.radiographic examination is of principal importance in the diagnosis and management of impacted teeth. the examination has several purposes: verification, analysis of anatomy, inclinations, relation to adjacent structures etc., and assessment of complications. fundamental radiographic methods are projections at right angles, horizontally or vertically angulated views, and stereoscopy. a detailed interpretation in three dimensions is essential for proper diagnosis and prognosis as well as for pla ...20123473038
chronic and acute effects of solvents on central nervous system functions in floorlayers.floorlayers and age matched carpenters with long (greater than or equal to 20 years) and short (5-10 years) occupational experience were compared with respect to chronic and acute neuropsychiatric, neuropsychological, and general health effects as related to different types of solvent exposure. an increased prevalence of neuropsychiatric illness occurred among floorlayers with long occupational experience, possibly caused by high levels of exposure which were present until the 1970s. the disease ...20123484970
the role of ungeremine in the growth-inhibiting and cytotoxic effects of lycorine: evidence and speculation. 20123406168
problem patients in a psychiatric inpatient setting. an explorative study.a total of 26 psychiatric inpatients (5.8% of all admissions) in an intensive treatment unit were identified as problem patients by nursing personnel. reasons for such identification were behavioral pathology of the patient, difficulties of the staff in the relationship with the patient, and insufficient therapeutic progress, and the use of inappropriate therapeutic methods. compared with a control group, the problem patients were psychotics or personality disorders. they presented more behavior ...20123732342
[age-related characteristics of the enamel surface microrelief before and after exposure to acid]. 20123284013
nuclear morphometry as an important prognostic factor in stage i renal cell carcinoma.although 60% of stage i renal carcinoma patients die from tumor within 5 years postoperatively, a considerable percentage survive that period. nuclear grading can help to predict the outcome, but many of the patients are grade 2, and the prognosis of this subclass is uncertain. therefore, nuclear morphometry was carried out in 41 patients with stage i renal cell carcinoma. of these, 24 died within 5 years and 17 have survived that period. using a mean nuclear area of 32 micron 2 as the decision ...20123768843
recruit and retain. tailor-made training. 20123353263
gunshot wounds in children under 10 years of age. a new epidemic.before 1980 we had not treated any children with gunshot wounds who were younger than 10 years of age, but the number has increased dramatically each year since then. thirty-four children younger than 10 years of age were treated for gunshot wounds from 1980 to 1987. sociologic and epidemiologic data were assessed by a child-abuse team and police. other studies have concluded that gunshot wounds in young children were usually caused by unintentional injury, child abuse, or neglect. from our pres ...20123369400
microsaccades and vision. 20123352933
a programme for aids. 20123380709
perivascular iron deposition and other vascular damage in multiple sclerosis.evidence of damage to cerebral vein walls was sought in 70 cases of multiple sclerosis. seventy control cases were also examined. the multiple sclerosis cases showed venous intramural fibrinoid deposition (7%), recent haemorrhages (17%), old haemorrhages revealed by haemosiderin deposition (30%), thrombosis (6%) and thickened veins (19%). in all, 41% of all multiple sclerosis cases showed some evidence of vein damage. occasional control cases showed haemosiderin deposition in the brain but, unli ...20123346691
the clinical stimulus to research on parasitic disease: lessons from life. 20123318514
[biliary reconstruction by choledocho-jejunal anastomosis with a y-loop in hepatic transplantation. analysis of complications]. 20123324906
hollenback prize for 1987 (gunnar ryge). 20123295791
primate research and "psychological well-being".in mark crawford's news & comment article "superconductor funds flat" (4 mar., p. 1089), robert j. birgeneau was reported to have had his grant cut to $4.4 million. that national science foundation grant actually covers the massachusetts institute of technology's materials research laboratory and supports 40 faculty members. birgeneau's personal grant was reduced from $125,000 in 1987 to $122,000 for this year.20123353701
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