Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| use of 2-d electrophoresis and esi mass spectrometry techniques to characterize fusobacterium nucleatum proteins up-regulated after oxidative stress. | the genus fusobacterium belongs to the fusobacteriaceae family and is a gram-negative obligate anaerobic bacterium found in the human oral microbiota. even that fusobacterium nucleatum cannot grow under aerobic conditions, they may exhibit aerotolerance as an adaptive response which could figure as an important virulence factor, during the stages of infection, when these anaerobes are shifted to aerobic conditions. in this regard, little is known about bacterial oxidative stress adaptive respons ... | 2010 | 19683589 |
| in reference to lemierre's syndrome: a systematic review. | 2010 | 19890952 | |
| vaccination targeting surface foma of fusobacterium nucleatum against bacterial co-aggregation: implication for treatment of periodontal infection and halitosis. | the mechanical therapy with multiple doses of antibiotics is one of modalities for treatment of periodontal diseases. however, treatments using multiple doses of antibiotics carry risks of generating resistant strains and misbalancing the resident body flora. we present an approach via immunization targeting an outer membrane protein foma of fusobacterium nucleatum (f. nucleatum), a central bridging organism in the architecture of oral biofilms. neutralization of foma considerably abrogated the ... | 2010 | 20189489 |
| quantification of five putative periodontal pathogens in female patients with and without chronic periodontitis by real-time polymerase chain reaction. | chronic periodontitis is a highly prevalent endogenous polymicrobial disease. to better understand the etiology of the disease a quantitative approach is mandatory and real-time pcr is the molecular technique currently preferred to achieve this purpose. taking into account that such a kind of study is still scarce, we aimed to evaluate the association between periodontal microbiota and chronic periodontitis. a total of 60 low-income age-matched female adults, 30 with chronic periodontitis and 30 ... | 2010 | 20193770 |
| [pelvic actinomycosis: a misleading picture]. | pelvic actinomycosis is a rare chronic suppurative granulomatous disease associated with an intrauterine contraceptive device. next pelvic organs can be affected but also more distant organs, to lead to different clinical situations. the diagnosis is therefore often difficult. we report here the case of a woman who presents a particular extensive pelvic actinomycosis diagnosed after surgical treatment with important morbidity. this case shows the interest of evoking the diagnosis in an evocative ... | 2010 | 20074892 |
| identification of bacteria enduring endodontic treatment procedures by a combined reverse transcriptase-polymerase chain reaction and reverse-capture checkerboard approach. | this study identified the bacterial taxa enduring endodontic treatment procedures by using a combined 16s ribosomal rna-based reverse-transcriptase polymerase chain reaction (rt-pcr) and reverse-capture checkerboard hybridization approach. | 2010 | 20003934 |
| full-mouth antimicrobial photodynamic therapy in fusobacterium nucleatum-infected periodontitis patients. | the purpose of this study is to clinically and microbiologically evaluate the effect of photodynamic therapy (pdt) as a full-mouth procedure in fusobacterium nucleatum-infected patients with periodontitis. | 2010 | 20350153 |
| biofilm formation enhances the oxygen tolerance and invasiveness of fusobacterium nucleatum in an oral mucosa culture model. | the present study evaluates the survival capability of fusobacterium nucleatum strains in an aerobic environment and compares the invasive capability of f. nucleatum in biofilm and planktonic forms in an organotypic cell culture (occ) model. | 2010 | 20350156 |
| [phlegmon of the palm of the hand as initial manifestation of the lemierre syndrome]. | lemierre's syndrome is a rare disease in young otherwise healthy people showing septic embolism in the lungs and peripheral vessels. we report the case of a 19-year-old male patient who presented initially with a phlegmon of the right palm and beginning septic shock. during the clinical course a subcutaneous abscess of the left shoulder, multiple lesions of the lungs and a pericardial abscess were identified and lemierre's syndrome was diagnosed. in this case, positron emission tomography (pet) ... | 2010 | 20024523 |
| cervical conization complicated by sepsis with lung and liver abscesses. | extrapelvic infections complicating cervical conization are exceedingly rare. | 2010 | 20354422 |
| should we expand the pharyngitis paradigm for adolescents and young adults? | 2010 | 20368663 | |
| case records of the massachusetts general hospital. case 10-2010. a 37-year-old woman with weakness and a mass in the brain. | 2010 | 20375410 | |
| mixture of periodontopathogenic bacteria influences interaction with kb cells. | the purpose of this study was to investigate the adhesion and invasion of periodontopathogenic bacteria in varied mixed infections and the release of interleukins from an epithelial cell line (kb cells). | 2010 | 20380884 |
| the role of anaerobic bacteria in bacteremia. | anaerobic bacteria remain an important cause of bloodstream infections and account for 1-17% of positive blood cultures. this review summarizes the epidemiology, microbiology, predisposing conditions, and treatment of anaerobic bacteremia (ab) in newborns, children, adults and in patients undergoing dental procedures. the majority of ab are due to gram-negative bacilli, mostly bacteroides fragilis group. the other species causing ab include peptostreptococcus, clostridium spp., and fusobacterium ... | 2010 | 20025984 |
| antimicrobial activity of super-oxidised water against oral microorganisms. | the radical anion of oxygen (o(-)) is extremely oxidative and shows high reactivity. in this study, the antibacterial activity of water super-oxidised water containing high concentration of o(-) (o(-)-water) was tested against cultured planktonic cells of cariogenic bacteria, periodontopathic bacteria and candida albicans. | 2010 | 20381790 |
| direct 16s rrna gene sequencing of polymicrobial culture-negative samples with analysis of mixed chromatograms. | two cases involving polymicrobial culture-negative samples were investigated by 16s rrna gene sequencing, with analysis of mixed chromatograms. fusobacterium necrophorum, prevotella intermedia and streptococcus constellatus were identified from pleural fluid in a patient with lemierre's syndrome and neisseria meningitidis and escherichia coli were identified from a petechia in a patient with meningococcal disease. | 2010 | 20035024 |
| detection of a mixed infection in a culture-negative brain abscess by broad-spectrum bacterial 16s rrna gene pcr. | we describe the identification of two bacterial pathogens from a culture-negative brain abscess by the use of broad-spectrum 16s rrna gene pcr. simultaneous detection of fusobacterium nucleatum and porphyromonas endodontalis was possible due to a 24-bp length difference of their partially amplified 16s rrna genes, which allowed separation by high-resolution polyacrylamide gel electrophoresis. | 2010 | 20392909 |
| [effect of periodontal mechanical treatment on periodontal pathogenic bacteria in gingival crevicular fluid of chronic periodontitis patients]. | to evaluate the subgingival prevalent rates of 6 periodontal pathogenic bacteria in gingival crevicular fluids of cp patients before and after treatment, to analyze the relationship between the prevalent variance and periodontal clinical parameters, and to provide a microbiologic method of evaluating curative effect and estimating the prognosis. | 2010 | 20396365 |
| substrate-dependent proton antiport in neurotransmitter:sodium symporters. | neurotransmitter-sodium symporters (nss), targets for psychostimulants and therapeutic drugs, have a critical role in neurotransmission. whereas eukaryotic nss show chloride-dependent transport, bacterial nss feature cl(-)-independent substrate transport. recently we showed that mutation of an acidic residue near one of the sodium ion-binding sites in leut of aquifex aeolicus or tyt1 of fusobacterium nucleatum renders substrate binding and/or transport cl(-) dependent. we reasoned that the negat ... | 2010 | 20081826 |
| innate inflammatory responses of human decidual cells to periodontopathic bacteria. | the purpose of this study was to test the hypothesis that periodontopathic bacteria exert potent proinflammatory effects in human decidua. | 2010 | 20452492 |
| polymerase chain reaction-denaturing gradient gel electrophoresis, cloning, and sequence analysis of bacteria associated with acute periapical abscesses in children. | polymerase chain reaction-denaturing gradient gel electrophoresis (pcr-dgge), cloning, and sequencing were applied to the microbiologic study of acute periapical abscesses of endodontic origin in children to examine the predominant bacteria. | 2010 | 20113778 |
| communication: antimicrobial activity of smap28 with a targeting domain for porphyromonas gingivalis. | antibiotic therapy is often used with mechanical therapy to treat periodontal disease. however, complications associated with antibiotic use can occur. a 'bacteria-specific' targeted approach would eliminate some of these complications and kill specific periodontopathogens without harming the commensal bacteria. one such approach is to couple antimicrobial peptides to a ligand, pheromone, or antibody specific for the periodontopathogen, porphyromonas gingivalis. to assess the feasibility of this ... | 2010 | 20454638 |
| antibacterial effects of mdpb against anaerobes associated with endodontic infections. | to investigate the antibacterial effects of 12-methacryloyloxydodecylpyridinium bromide (mdpb), an antibacterial monomer synthesized by combining quaternary ammonium with a methacryloyl group, against three anaerobes associated with endodontic infections using planktonic and biofilm cells. | 2010 | 20456514 |
| effects of methyl gallate and gallic acid on the production of inflammatory mediators interleukin-6 and interleukin-8 by oral epithelial cells stimulated with fusobacterium nucleatum. | interactions between periodontal bacteria and human oral epithelial cells can lead to the activation and expression of a variety of inflammatory mediators in epithelial cells. fusobacterium nucleatum is a filamentous human pathogen that is strongly associated with periodontal diseases. this study examined the effects of methyl gallate (mg) and gallic acid (ga) on the production of inflammatory mediators, interleukin (il)-6 and il-8, by oral epithelial cells stimulated by f. nucleatum. in a real- ... | 2010 | 20127471 |
| lemierre syndrome: report of five new cases and literature review. | lemierre syndrome (ls) is relatively rare, and its clinical features are potentially confusing. without proper therapy, ls is associated with significant morbidity and is potentially fatal. recognition of the imaging features of ls in the chest and the neck may permit a timely diagnosis and lead to prompt institution of appropriate therapy. the emergency imaging features of ls in five cases are reviewed with emphasis on computed tomography of the chest and neck. | 2010 | 20135186 |
| production of indole from l-tryptophan and effects of these compounds on biofilm formation by fusobacterium nucleatum atcc 25586. | the l-tryptophan degradation product indole is a purported extracellular signaling molecule that influences biofilm formation in various bacteria. here we analyzed the mechanisms of indole production in fusobacterium nucleatum and the effects of tryptophan and indole on f. nucleatum planktonic and biofilm cells. the amino acid sequence deduced from the fn1943 gene in f. nucleatum atcc 25586 was 28% identical to that deduced from tnaa in escherichia coli, which encodes tryptophanase catalyzing th ... | 2010 | 20472741 |
| effects of a mouthwash with chlorine dioxide on oral malodor and salivary bacteria: a randomized placebo-controlled 7-day trial. | previous research has shown the oxidizing properties and microbiological efficacies of chlorine dioxide (clo2). its clinical efficacies on oral malodor have been evaluated and reported only in short duration trials, moreover, no clinical studies have investigated its microbiological efficacies on periodontal and malodorous bacteria. thus, the aim of this study was to assess the inhibitory effects of a mouthwash containing clo2 used for 7 days on morning oral malodor and on salivary periodontal a ... | 2010 | 20152022 |
| competition between yogurt probiotics and periodontal pathogens in vitro. | to investigate the competition between probiotics in bio-yogurt and periodontal pathogens in vitro. | 2010 | 20491536 |
| identification of immunological parameters associated with the alveolar bone level in periodontal patients. | the present study was performed to clarify the relationship between periodontal disease severity and selected immunological parameters consisting of serum igg titer against periodontopathogenic bacteria, the expression of the helper t-cell cytokine by gingival mononuclear cells, and patients' immunoreactivity to cross-reactive heat shock protein (hsp) epitope peptide from p. gingivalis hsp60. | 2010 | 20498762 |
| in vitro cytokine responses to periodontal pathogens: generalized aggressive periodontitis is associated with increased il-6 response to porphyromonas gingivalis. | generalized aggressive periodontitis (gagp) is an inflammatory condition resulting in destruction of tooth-supporting tissues. we examined the production of il-1beta, il-6, tumour necrosis factor (tnf)-alpha, il-12 and il-10 in cultures of peripheral mononuclear cells (mnc) from 10 patients with gagp and 10 controls stimulated with periodontal pathogens or a control antigen, tetanus toxoid (tt) in the presence of autologous serum. the pathogens used were porphyromonas gingivalis, prevotella inte ... | 2010 | 20500696 |
| lemierre syndrome: a japanese patient returning from thailand. | after returning from thailand, a 23-year-old japanese man was admitted because of fever, sore throat, neck pain, and chest pain. contrasted-enhanced ct scanning of his neck revealed an absence of flow through the right internal jugular vein representing thrombosis, and moreover, an increase in wall thickness of the right internal jugular vein and enhancement of the surrounding tissue representing thrombophlebitis. lung abscesses were also identified by a chest ct scan. fusobacterium nucleatum wa ... | 2010 | 20177952 |
| the recolonization hypothesis in a full-mouth or multiple-session treatment protocol: a blinded, randomized clinical trial. | to test recolonization of periodontal lesions after full-mouth scaling and root planing (fm-srp) or multiple session-srp (ms-srp) in a randomized clinical trial and whether fm-srp and ms-srp result in different clinical outcomes. | 2010 | 20507375 |
| mechanical non-surgical treatment of peri-implantitis: a single-blinded randomized longitudinal clinical study. ii. microbiological results. | peri-implantitis is common in patients with dental implants. we performed a single-blinded longitudinal randomized study to assess the effects of mechanical debridement on the peri-implant microbiota in peri-implantitis lesions. | 2010 | 20507380 |
| sore throat progressing to embolic sepsis: a case of lemierre's syndrome. | lemierre's syndrome is a rare clinical syndrome defined as orophyngeal sepsis, thrombophlebitis of the internal jugular vein and septic thombo-emboli. it is typically encountered in young, immunocompetent individuals, with a mean incident age of 20 years. the organism that is most commonly associated is an anaerobic gram-negative bacterium: fusobacterium species. the defined treatment course is at least six weeks of antibiotics, with the role of anticoagulation being unclear. the present article ... | 2010 | 20186362 |
| effects of a composition containing lactoferrin and lactoperoxidase on oral malodor and salivary bacteria: a randomized, double-blind, crossover, placebo-controlled clinical trial. | we report a clinical trial of the effects of test tablets containing bovine lactoferrin and lactoperoxidase on oral malodor and salivary bacteria. fifteen subjects with volatile sulfur compounds (vscs) in mouth air above the olfactory threshold (h(2)s >1.5 or ch(3)sh >0.5 ng/10 ml) as detected by gas chromatography were enrolled in the trial. either a test or a placebo tablet was ingested twice at 1-h intervals in two crossover phases. mouth air was monitored for vsc levels at the baseline befor ... | 2010 | 20512389 |
| antimicrobial efficacy of 3 oral antiseptics containing octenidine, polyhexamethylene biguanide, or citroxx: can chlorhexidine be replaced? | use of oral antiseptics decreases the bacterial load in the oral cavity. | 2010 | 20518635 |
| [lemierre syndrome]. | lemierre's syndrome is a rare and severe condition, with a primary focus in the cervicofacial area and followed by thrombosis of the internal jugular vein and metastatic infections, most often pulmonary. the principal pathogen is fusobacterium necrophorum. less rare and associated with high mortality before antibiotics, lemierre syndrome had became exceptional until the increase in the number of cases in recent years. recovery is usually the rule, but often only after long convalescence and ofte ... | 2010 | 19914026 |
| gram-negative periodontal bacteria induce the activation of toll-like receptors 2 and 4, and cytokine production in human periodontal ligament cells. | periodontitis is a bacterially induced chronic inflammatory disease. toll-like receptors (tlrs), which could recognize microbial pathogens, are important components in the innate and adaptive immune systems. both qualitatively and quantitatively distinct immune responses might result from different bacteria stimulation and the triggering of different tlrs. this study explores the interaction of porphyromonas gingivalis, prevotella intermedia, fusobacterium nucleatum, and aggregatibacter actinomy ... | 2010 | 20528699 |
| folding of a transcriptionally acting preq1 riboswitch. | 7-aminomethyl-7-deazaguanine (preq(1)) sensitive mrna domains belong to the smallest riboswitches known to date. although recent efforts have revealed the three-dimensional architecture of the ligand-aptamer complex less is known about the molecular details of the ligand-induced response mechanism that modulates gene expression. we present an in vitro investigation on the ligand-induced folding process of the preq(1) responsive rna element from fusobacterium nucleatum using biophysical methods, ... | 2010 | 20534493 |
| digital necrobacillosis in norwegian wild tundra reindeer (rangifer tarandus tarandus). | outbreaks of digital necrobacillosis in norwegian wild tundra reindeer (rangifer tarandus tarandus) are described. the outbreaks occurred in late summer and autumn 2007 and 2008, subsequent to periods with an unusually high number of days with precipitation and high air temperature. lesions were generally restricted to one foot and the disease incidence was highest in calves. single limbs from 20 animals and six whole carcasses were submitted for laboratory examination. gross lesions were charac ... | 2010 | 20156626 |
| necrobacillosis: a case report of complicated fusobacterium necrophorum septicemia. | necrobacillosis due to fusobacterium necrophorum is an uncommon anaerobic infection. it has a wide range of presentations and commonly presents as lemierre's syndrome. we present a case of necrobacillosis defined by f. necrophorum bacteremia with epidural and pararectal fluid collection without evidence of internal jugular vein thrombophlebitis. | 2010 | 19501182 |
| photodynamic therapy of persistent pockets in maintenance patients-a clinical study. | the aim of this study was to compare the short-term performance of a session of single photodynamic therapy (pdt) and of a conventional ultrasonic debridement (ust) in persistent pockets of maintenance patients. in a prospective, randomized, controlled, single-blind clinical study, patients with chronic periodontitis with at least two persistent pockets (>4 mm) were enrolled. they were treated either with ust (n = 29) or pdt (n = 25). clinical and microbiological examinations were performed at b ... | 2010 | 19823880 |
| mixed infection involving actinomyces, aggregatibacter, and fusobacterium species presenting as perispinal tumor. | a representative case in which a polymicrobial infection involving fusobacterium nucleatum, actinomyces israelii and aggregatibacter (formerly actinobacillus) actinomycetemcomitans was initially diagnosed as malignancy in an edentulous patient. additional history obtained after the nature of the syndrome was elucidated revealed that he had had his two remaining teeth extracted four months prior to this episode. | 2010 | 19628046 |
| mobilization and prevalence of a fusobacterial plasmid. | fusobacterium nucleatum is a gram-negative anaerobic rod found in dental plaque biofilms, and is an opportunistic pathogen implicated in periodontitis as well as a wide range of systemic abscesses and infections. genomic analyses of f. nucleatum indicate considerable genetic diversity and a prominent role for horizontal gene transfer in the evolution of the species. several plasmids isolated from f. nucleatum, including pfn1, harbor relaxase gene homologs that may function in plasmid mobilizatio ... | 2010 | 19761790 |
| microbial profile of ligature-induced periodontitis in rats. | the aim of this study was to evaluate the composition of the biofilm accumulated around ligatures in rats by checkerboard dna-dna hybridization using probes made from human oral bacterial species. | 2010 | 19931851 |
| a first report on the microbial colonisation of the equine oesophagus. | based on cryo-sem, standard and high resolution tem, glycoconjugate histochemistry, and microbiological differentiation, the present study demonstrates the colonisation of the epithelium of the equine oesophagus with microorganisms. as particularly apparent using cryo-sem to illustrate natural conditions, the present microbiota were clearly dominated by bacteria, forming a one-layer system, as attached to and embedded in concentrated mannose/mannan substances covering the outer stratum corneal c ... | 2010 | 19942420 |
| fusobacterium necrophorum variants present on the hooves of lame pigs. | 2010 | 19781870 | |
| lemierre syndrome. | 2010 | 19997729 | |
| fusobacterium necrophorum multiple abscesses in children with sickle cell disease. | 2010 | 20002625 | |
| bacterial adhesins to host components in periodontitis. | 2010 | 20017793 | |
| starch-entrapped microspheres show a beneficial fermentation profile and decrease in potentially harmful bacteria during in vitro fermentation in faecal microbiota obtained from patients with inflammatory bowel disease. | the purpose of this research was to test the hypothesis that starch-entrapped microspheres would produce favourable fermentation profiles and microbial shifts during in vitro fermentation with the faecal microbiota from patients with inflammatory bowel disease (ibd). in vitro fermentation was carried out using a validated, dynamic, computer-controlled model of the human colon (toegepast natuurwetenschappelijk onderzoek gastro-intestinal model-2) after inoculation with pooled faeces from healthy ... | 2010 | 20021704 |
| diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyryl-coa:acetate coa-transferase gene. | butyrate-producing bacteria play an important role in the human colon, supplying energy to the gut epithelium and regulating host cell responses. in order to explore the diversity and culturability of this functional group, we designed degenerate primers to amplify butyryl-coa:acetate coa-transferase sequences from faecal samples provided by 10 healthy volunteers. eighty-eight per cent of amplified sequences showed >98% dna sequence identity to coa-transferases from cultured butyrate-producing b ... | 2010 | 19807780 |
| diagnostic microarray for human and animal bacterial diseases and their virulence and antimicrobial resistance genes. | rapid diagnosis and treatment of disease is often based on the identification and characterization of causative agents derived from phenotypic characteristics. current methods can be laborious and time-consuming, often requiring many skilled personnel and a large amount of lab space. the objective of our study was to develop a spotted microarray for rapid identification and characterization of bacterial pathogens and their antimicrobial resistance genes. our spotted microarray consists of 489 70 ... | 2010 | 20035807 |
| nod1 and nod2 mediate sensing of periodontal pathogens. | in bacterial infection, nucleotide-binding oligomerization domain (nod) 1 and nod2 induce innate immune responses by recognizing fragments of the bacterial component peptidoglycan (pgn). to determine the roles of these receptors in detection of periodontal pathogens, we stimulated human embryonic kidney cells expressing nod1 or nod2 with heat-killed porphyromonas gingivalis, aggregatibacter actinomycetemcomitans, and fusobacterium nucleatum or their soluble pgns (spgns). all bacteria and their s ... | 2010 | 20040739 |
| microbiologic testing and outcomes of full-mouth scaling and root planing with or without amoxicillin/metronidazole in chronic periodontitis. | it has been suggested that use of systemic antibiotics should be limited to patients with specific microbiologic profiles. the main purpose of the present analysis was to study whether microbiologic testing before therapy was of value in predicting which patients would specifically benefit from adjunctive amoxicillin and metronidazole, given in the context of full-mouth scaling and root planing (srp) within 48 hours. | 2010 | 20059413 |
| in vitro killing activity of crevicular concentrations of tinidazole plus common oral antibiotics against high-density mixed inocula of periodontal pathogens in strict anaerobic conditions. | odontogenic infections are polymicrobial. this study explores the in vitro killing activity by concentrations similar to those found in crevicular fluid of tinidazole in combination with amoxicillin/clavulanic acid, clindamycin and levofloxacin against four groups of high-density mixed inocula of anaerobes (prevotella buccae, fusobacterium nucleatum, and veillonella spp.) and facultative (capnocytophaga spp. and streptococcus spp.) isolates of periodontal pathogens. | 2010 | 20059425 |
| [septic osteomyelitis of the hip after fusobacterium necrophorum pharyngitis]. | case report: we report the case of a patient presenting with lemierre's syndrome with an initial atypical presentation due to a predominant hip localization. despite the adapted antibiotic treatment and surgical drainage, the patient relapsed. the bone and joint biopsy samples were sterile but the presence of the fusobacterium necrophorum was demonstrated by pcr. conclusion: lemierre's syndrome may have different clinical presentations, due to the localizations of septic emboli. careful attentio ... | 2010 | 19959308 |
| undetected lkta genes within fusobacterium necrophorum? | 2010 | 20075116 | |
| efficacy of a low-concentration chlorhexidine mouth rinse in non-compliant periodontitis patients attending a supportive periodontal care programme: a randomized clinical trial. | to assess the clinical and microbiological efficacy of a 0.05% chlorhexidine and 0.05% cetyl-pyridinium chloride mouth rinse in supportive periodontal care (spc) in patients with inadequate plaque control. | 2010 | 20088984 |
| use of a novel assay to evaluate enzymes that produce hydrogen sulfide in fusobacterium nucleatum. | to evaluate enzymes that produce hydrogen sulfide (h(2)s) in species of fusobacterium nucleatum, we developed an assay based on sds-polyacrylamide gel electrophoresis with renaturation followed by active staining. this assay provided precise insight into the enzymes that produce h(2)s in terms of their number and molecular weights. | 2010 | 20093145 |
| term stillbirth caused by oral fusobacterium nucleatum. | intrauterine infection is a recognized cause of adverse pregnancy outcome, but the source of infection is often undetermined. we report a case of stillbirth caused by fusobacterium nucleatum that originated in the mother's mouth. | 2010 | 20093874 |
| epithelial cell pro-inflammatory cytokine response differs across dental plaque bacterial species. | the dental plaque is comprised of numerous bacterial species, which may or may not be pathogenic. human gingival epithelial cells (hgecs) respond to perturbation by various bacteria of the dental plaque by production of different levels of inflammatory cytokines, which is a putative reflection of their virulence. the aim of the current study was to determine responses in terms of interleukin (il)-1beta, il-6, il-8 and il-10 secretion induced by porphyromonas gingivalis, aggregatibacter actinomyc ... | 2010 | 20096064 |
| the bactericidal effect of a genius nd:yag laser. | to evaluate the 'in vitro' bactericidal effect of the nd:yag laser (genius, mølsgaard dental, copenhagen, denmark) on six periodontal pathogens. | 2010 | 20096084 |
| eponym: the lemierre syndrome. | fig. 1 dr. andre lemierre lemierre syndrome, also known as postanginal sepsis, is a severe complication of an acute oropharyngeal infection that results in septic thrombophlebitis of the ipsilateral internal jugular vein with subsequent septicemia, often complicated by metastatic infections. the usual agent in lemierre syndrome is fusobacterium necrophorum, a commensal bacillus of the oral cavity. after the advent of antibiotic therapy, especially in the 1960s and 1970s, when penicillin was freq ... | 2010 | 20107834 |
| the antimicrobial efficacy of commercial dentifrices. | this investigation compared the effects of a fluoride dentifrice and toothpastes formulated with antimicrobial ingredients (stannous fluoride and triclosan/copolymer) on oral micro-organisms, including those found in samples taken from the human oral cavity. microbiological techniques determined the minimum inhibitory concentrations (mics) of each dentifrice necessary to inhibit the growth of bacterial strains from the healthy oral cavity, as well as those found in dental caries, periodontal dis ... | 2010 | 20129893 |
| change in diet and oral hygiene over an 8-week period: effects on oral health and oral biofilm. | the aim of the study was to monitor changes in oral health and oral biofilm composition in vivo during an experiment simulating prehistoric lifestyle and diet and poor oral hygiene. thirteen subjects lived for a period of 8 weeks under neolithic conditions. the following clinical parameters were recorded before and after the project: gingival and plaque index (löe and silness, acta odontol scand 21:533, 1963; silness and löe, acta odontol scand 22:121-135, 1964), probing pocket depth, and bleedi ... | 2010 | 19626350 |
| significant pathogens in peritonsillar abscesses. | peritonsillar abscesses (pta) are polymicrobial infections, with a diverse aerobic and anaerobic flora. the aim of the present study is to compare bacteriologic culture results from patients with pta to those from patients undergoing elective tonsillectomy (clinically non-infected tonsils), to better elucidate the pathogenic significance of various isolates. a prospective study was conducted on 36 pta patients undergoing acute tonsillectomy and on 80 electively tonsillectomised patients. fusobac ... | 2010 | 21181222 |
| cited2 is activated in ulcerative colitis and induces p53-dependent apoptosis in response to butyric acid. | in ulcerative colitis (uc), fusobacterium varium is significantly detected in patients' mucosa, and butyric acid (ba), abundantly produced by the bacterium, activates the p53 system and induces epithelial apoptosis, as we previously reported. however, factors active in the link between ba and p53 have yet to be clarified. here, we identified a gene activated by ba specifically in uc-associated cancer cell lines and ascertained the mechanism of its activation of p53. | 2010 | 21165656 |
| modeling of diffusion transport through oral biofilms with the inverse problem method. | the purpose of this study was to develop a mathematical model to quantitatively describe the passive transport of macromolecules within dental biofilms. | 2010 | 21404968 |
| preterm low birthweight and the role of oral bacteria. | preterm and low birthweight (ptlbw) continues to be a major cause of mortality and morbidity across the world. in recent years, maternal periodontal disease has been implicated as a risk factor for adverse pregnancy outcomes. there is conflicting evidence to support such an outcome as illustrated by descriptive, case control and randomised controlled trials involving pregnant women from across the world, using different measurement tools to determine the level of periodontal disease. whilst cons ... | 2010 | 21523222 |
| osteoradionecrosis contains a wide variety of cultivable and non-cultivable bacteria. | direct microscopy, anaerobic culture and dna-dna hybridization have previously demonstrated an association between microorganisms and osteoradionecrosis (orn). the purpose of our study was to use culture independent molecular techniques to detect bacteria in necrotic bone lesions of the mandible after radiation therapy. | 2010 | 21523230 |
| differential effects of periopathogens on host protease inhibitors slpi, elafin, scca1, and scca2. | secretory leukocyte peptidase inhibitors (slpi), elafin, squamous cell carcinoma antigen 1 and 2 (scca1 and scca2) are specific endogenous serine protease inhibitors expressed by epithelial cells that prevent tissue damage from excessive proteolytic enzyme activity due to inflammation. to determine the effects of various periopathogens on these protease inhibitors, we utilized human gingival epithelial cells (gecs) challenged with cell-free bacteria supernatants of various periopathogens porphyr ... | 2010 | 21523231 |
| development of species-specific polymerase chain reaction primers for detection of fusobacterium periodonticum. | the purpose of this study was to develop species-specific pcr primers for detection of fusobacterium periodonticum. the specificity data showed that two sets of pcr primers, fp-f3/fp-r2 and fp-f1/fp-r2 pcr, produced amplicons from all the f. periodonticum, but not from the other species tested, which included 12 fusobacterium species or subspecies and representative oral bacteria. the sensitivity of the primer sets was 4 or 40 pg of the chromosomal dna from f. periodonticum atcc 33693(t) . these ... | 2010 | 21223363 |
| evaluation of the antimicrobial activity of dentifrices on human oral bacteria. | in vitro testing of antimicrobial agents is an important tool in the testing hierarchy, and may provide interesting insights into their potential clinical efficacy. agents with demonstrable in vitro antimicrobial activity may be effective against the same microorganisms in vivo, whereas agents without demonstrable in vitro antimicrobial activity are unlikely to exhibit in vivo antimicrobial activity. in addition, these methods may also be useful in screening antimicrobial agents in product formu ... | 2010 | 21269037 |
| [study of putative periodontal pathogens colonies in type 2 diabetes with chronic periodontitis]. | ppurpose: to study the permanent planting of periodontal pathogens in the subgingival plaque of periodontitis patients with type 2 diabetes, and evaluate role of periodontal pathogens in chronic periodontitis and type 2 diabetes. | 2010 | 21431261 |
| comparative evaluation of bactericidal potential of four root canal filling materials against microflora of infected non-vital primary teeth. | since complete debridement of the root canals of the primary teeth is not practically possible due to the highly variable root canal anatomy, success of the endodontic therapy depends partly on the use ofantibacterial irrigating agents and root canal filling materials. recent literature indicates that anaerobes comprise a majority of the bacteria in necrotic root canals ofprimary teeth. the study determined the antibacterial effectiveness of four root canal filling materials namely calcium hydro ... | 2010 | 21189760 |
| lemierre syndrome: once seen it can never be mistaken. | lemierre syndrome is a rare but severe septicaemia due most frequently to fusobacterium necrophorum, with primary foci in the head, internal jugular vein thrombosis and metastatic infections, mainly in the lungs. we report two cases of lemierre syndrome admitted to the paediatric unit of our hospital at 2-month intervals. the first was 10 years old and the second one was a 3-month-old infant. they were diagnosed on the 25th hospital day and at the time of admission, respectively. in the first ca ... | 2009 | 21686487 |
| unusual findings and diagnostic challenges in a child with lemierre's disease. | 16s rdna polymerase chain reaction (pcr) in the diagnosis of fastidious organisms is becoming increasingly commonplace. we present the case of a child admitted to an acute paediatric unit of a university teaching hospital with otorrhoea, torticollis, and cervical lymphadenopathy. examination revealed hepatosplenomegaly associated with pancytopenia. radiological imaging confirmed a retropharyngeal abscess, bilateral mastoiditis, cerebellar lesions, and venous sinus thrombosis. swabs of aural disc ... | 2009 | 21833343 |
| bacterial diversity in persistent periapical lesions on root-filled teeth. | the purpose of this study was to analyze the bacterial diversity in persistent apical lesions on root-filled teeth by using culture-independent molecular methods. | 2009 | 21523213 |
| large scale biomimetic membrane arrays. | to establish planar biomimetic membranes across large scale partition aperture arrays, we created a disposable single-use horizontal chamber design that supports combined optical-electrical measurements. functional lipid bilayers could easily and efficiently be established across co(2) laser micro-structured 8 x 8 aperture partition arrays with average aperture diameters of 301 +/- 5 microm. we addressed the electro-physical properties of the lipid bilayers established across the micro-structure ... | 2009 | 19672582 |
| fusobacterium nucleatum enters normal human oral fibroblasts in vitro. | fusobacterium nucleatum, a commensal opportunistic oral bacterium, is capable of invading gingival epithelial cells, but the entrance into human primary oral fibroblast cells has not been documented. this study evaluated the ability of three strains of f. nucleatum (f. nucleatum ssp. nucleatum, f. nucleatum ssp. polymorphum, and f. nucleatum ssp. vincentii) to enter gingival fibroblasts (gfs) and periodontal ligament fibroblasts (plfs). | 2009 | 19563299 |
| discrimination between bacteroides, dichelobacter, fusobacterium, porphyromonas and prevotella isolated from caprine footrot by pcr-rflp - short communication. | footrot is widely considered the most severe and most common foot pathology in small ruminants. this study tested the ability of a molecular typing system based on polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) assay of the 16s rrna gene to discriminate between the strict anaerobe genera most commonly isolated from footrot ( bacteroides, dichelobacter, fusobacterium, porphyromonas and prevotella ) in goats in extremadura (spain), with a view to facilitating identif ... | 2009 | 19584033 |
| real-time polymerase chain reaction to determine the prevalence and copy number of epstein-barr virus and cytomegalovirus dna in subgingival plaque at individual healthy and periodontal disease sites. | detection of cytomegalovirus (cmv) and epstein-barr virus (ebv) in plaque from patients with periodontal disease provides support for the theory that these viruses play a role in the pathogenesis of periodontitis. this study sought to further define this relationship by determining the prevalence of these viruses at individual disease and healthy sites of patients with periodontal disease and to determine whether the presence and amount of viral dna correlate with disease severity. | 2009 | 19563294 |
| a 21-year-old man with fever and abdominal pain after recent peritonsillar abscess drainage. | lemierre syndrome an extremely rare and unreported disease typically results from oropharyngeal infection and/or local tissue trauma with invasion of the parapharyngeal soft tissue with bacteria. once local tissue invasion occurs, internal jugular vein septic thrombophlebitis with or without metastatic complications may occur. the etiology of lemierre syndrome is generally fusobacterium necrophorum, reported to be present in approximately 80% of the cases. the outcome of lemierre syndrome in the ... | 2009 | 19555636 |
| brain abscess complicating foreign body aspiration. | 2009 | 19960853 | |
| [an underestimated throat bacteria]. | 2009 | 19756058 | |
| community-acquired methicillin-resistant staphylococcus aureus and lemierre syndrome. | lemierre syndrome is usually caused by fusobacterium necrophorum, but we recently encountered a case due to methicillin-resistant staphylococcus aureus and complicated by sigmoid sinus thrombosis and cranial neuropathies. therapy may be made more difficult by unusual organisms and also create the need for therapy that penetrates into the central nervous system. | 2009 | 19701080 |
| a case of brain abscess extended from deep fascial space infection. | a case of brain abscess in the temporal lobe caused by direct intracranial extension of deep neck abscess is described. the abscess also spread to the orbital cavity through infraorbital fissure. the possible etiology of this case might be dental surgery. the diagnostic imaging clearly showed the routes of intracranial and -orbital extension of parapharyngeal and masticator space abscesses. from the abscess specimens, oral streptococci, anaerobic streptococci, and anaerobic gram-negative bacilli ... | 2009 | 19716487 |
| transmission of periodontopathic bacteria from natural teeth to implants. | purpose: prevention of peri-implantitis is essential for the success of implant rehabilitation. infection by periodontopathic bacteria is a major cause of peri-implantitis. the aim of the present study was to identify the source of peri-implant colonization by periodontopathic bacteria. materials and methods: twenty-one patients with implants were enrolled in the study. subgingival plaque samples from the adjacent, occluding, and contralateral natural teeth were collected prior to second-stage s ... | 2009 | 20002682 |
| defining the healthy "core microbiome" of oral microbial communities. | most studies examining the commensal human oral microbiome are focused on disease or are limited in methodology. in order to diagnose and treat diseases at an early and reversible stage an in-depth definition of health is indispensible. the aim of this study therefore was to define the healthy oral microbiome using recent advances in sequencing technology (454 pyrosequencing). | 2009 | 20003481 |
| lemierre syndrome and unexpected death in childhood. | lemierre syndrome refers to necrotizing infections of the head due to fusobacterium necrophorum and has been called the 'forgotten disease' due to its rarity in the antibiotic era. recently, however, more cases have been documented in the literature suggesting that there has been an increase in incidence. a 10-year-old boy is reported who had a five-day history of ear infection, with the development of fever, drowsiness and ipsilateral neck swelling. unexpected cardiac arrest occurred soon after ... | 2009 | 19782321 |
| epidemiology of pharyngeal carriage of fusobacterium necrophorum. | 2009 | 19528186 | |
| expand the pharyngitis paradigm for adolescents and young adults. | current guidelines and review articles emphasize that clinicians should consider group a beta-hemolytic streptococcus in the diagnosis and management of patients with acute pharyngitis. recent data suggest that in adolescents and young adults (persons aged 15 to 24 years), fusobacterium necrophorum causes endemic pharyngitis at a rate similar to that of group a beta-hemolytic streptococcus. on the basis of published epidemiologic data, f. necrophorum is estimated to cause the lemierre syndrome-a ... | 2009 | 19949147 |
| fusobacterium bacteremia: clinical significance and outcomes. | fusobacterium bacteremia is uncommon, accounting for approximately 0.9% of patients with bacteremia. the objectives of this study were to evaluate the incidence and clinical significance of blood cultures positive for fusobacterium spp., risk factors for mortality, and the impact of antimicrobial therapy on clinical outcomes. | 2009 | 19949758 |
| [dyspnea with fever]. | 2009 | 19953051 | |
| [acute mastoiditis in children: can mastoidectomy be avoided?]. | mastoidectomy is the standard management for exteriorized mastoiditis. the objective of this study was to assess the results of conservative management of acute mastoiditis and to study the types of bacteria isolated and their sensitivity to antibiotics. | 2009 | 19524875 |
| [from tonsillitis to coxitis]. | we present a 19-year-old woman with a throat infection, increased temperature, a positive mononucleosis monospot test and clinical signs of a lower respiratory tract infection. the diagnosis was thought to be mononucleosis complicated by bacterial pneumonia, but she was later found to have fusobacterium necrophorum in blood cultures. she subsequently developed metastatic abscesses in her lungs and hip joint and was diagnosed with lemierre's syndrome. this case report highlights the importance of ... | 2009 | 19756057 |
| coenzyme recognition and gene regulation by a flavin mononucleotide riboswitch. | the biosynthesis of several protein cofactors is subject to feedback regulation by riboswitches. flavin mononucleotide (fmn)-specific riboswitches, also known as rfn elements, direct expression of bacterial genes involved in the biosynthesis and transport of riboflavin (vitamin b(2)) and related compounds. here we present the crystal structures of the fusobacterium nucleatum riboswitch bound to fmn, riboflavin and antibiotic roseoflavin. the fmn riboswitch structure, centred on an fmn-bound six- ... | 2009 | 19169240 |
| hydrogen sulfide production from cysteine and homocysteine by periodontal and oral bacteria. | hydrogen sulfide is one of the predominant volatile sulfur compounds (vscs) produced by oral bacteria. this study developed and evaluated a system for detecting hydrogen sulfide production by oral bacteria. | 2009 | 19905954 |
| sonic extracts from a bacterium related to periapical disease activate gelatinase a and inactivate tissue inhibitor of metalloproteinases timp-1 and timp-2. | to examine the effects of sonicated bacterial extracts (sbes) from three related to periapical disease bacteria (porphyromonas gingivalis, p. endodontalis and f. nucleatum) on the activation of matrix metalloproteinase (mmp-2) and the inactivation of tissue inhibitors of metalloproteinase (timp-1 and timp-2). | 2009 | 19912382 |