a critical analysis of the role of gut oxalobacter formigenes in oxalate stone disease.hyperoxaluria is a major risk factor for the formation of calcium oxalate stones, but dietary restriction of oxalate intake might not be a reliable approach to prevent recurrence of stones. hence, other approaches to reduce urinary oxalate to manage stone disease have been explored. the gut-dwelling obligate anaerobe oxalobacter formigenes (of) has attracted attention for its oxalate-degrading property. in this review we critically evaluate published studies and identify major gaps in knowledge. ...200919021605
[infection and urinary lithiasis].urinary infection is a risk factor for lithiasis. urinary tract infection is a factor of gravity of urinary stone. the stone can exist before the infection which colonizes the stone, infected stone. the infection can be the cause of the stone, infectious stone (struvite stone). infectious stones can be secondary to a non urinary infectious agent, oxalobacter formigenes (of) and nanobacteria. the first-line treatment of struvite stone is percutaneous surgery. perioperative antibiotics, renal urin ...200819033073
recent advances in the pathophysiology of nephrolithiasis.over the past 10 years, major progress has been made in the pathogenesis of uric acid and calcium stones. these advances have led to our further understanding of a pathogenetic link between uric acid nephrolithiasis and the metabolic syndrome, the role of oxalobacter formigenes in calcium oxalate stone formation, oxalate transport in slc26a6-null mice, the potential pathogenetic role of randall's plaque as a precursor for calcium oxalate nephrolithiasis, and the role of renal tubular crystal ret ...200919078968
prospects for dietary therapy of recurrent nephrolithiasis.the goal of this article is to propose a randomized controlled trial (rct) that tests a hypothesis that dietary manipulation prevents recurrent kidney stones. dietary interventions based on epidemiologic and pathophysiologic data are reviewed. the only diet trial successful in preventing stones showed that calcium intake of 1,200 mg/d, accompanied by restriction of animal protein, salt, and oxalate ingestion, was superior to 400 mg of calcium and restricted oxalate intake. this study may be wort ...200919095202
presence of oxalobacter formigenes in the stool of healthy dogs. 200919193501
[construction of oxalate-degrading intestinal stem cell population in mice].the oxalate-degradation genes of oxalobacter formigenes (ox.f)-frc gene and oxc gene-were cloned and transfected into intestinal stem cell population of the mouse to make the latter obtain oxalate-degradation function.200919595148
variation in shedding of oxalobacter formigenes in feces of healthy dogs. 200919595523
intestinal colonization with oxalobacter formigenes and its relation to urinary oxalate excretion in pediatric patients with idiopathic calcium urolithiasis.oxalobacter formigenes is an intestinal bacterium that utilizes oxalate as the only source of energy. it has been suggested that the lack of colonization with this organism may be a risk factor for calcium oxalate urolithiasis. because this problem was not investigated in pediatric stone formers, we decided to assess it in our patients.200919766900
identification of oxalobacter formigenes in the faeces of healthy cats.oxalobacter formigenes is an oxalate-degrading intestinal bacterium that has been found in humans, cattle, sheep, rats and dogs. its presence in the intestinal tract may be a protective factor against calcium oxalate urolithiasis because of its ability to degrade oxalate. the objective of this study was to determine whether o. formigenes could be detected in the faeces of healthy cats.200919780961
could the urolithiasis be treated by anti-nanobacterial therapy? 201020022710
probiotic-induced reduction of gastrointestinal oxalate absorption in healthy subjects.both a high dietary oxalate intake and increased intestinal absorption appear to be major causes of elevated urine oxalate, a risk factor for kidney stone formation. by favorably altering the gastrointestinal bacterial population, probiotics have the potential to lower oxalate absorption/urinary excretion. this study assessed whether a 4-wk daily consumption of a commercially available probiotic by 11 healthy volunteers (8 females, 3 males), aged 21-36 y, would decrease oxalate absorption. the s ...201020224931
oxalate-degrading bacteria of the human gut as probiotics in the management of kidney stone disease.humans lack the enzymes needed to metabolize endogenous and dietary oxalate, a toxic compound causing hyperoxaluria and calcium oxalate urolithiasis. oxalate in humans can be eliminated through (1) excretion in urine, (2) forming insoluble calcium oxalate and elimination in feces, or (3) oxalate degradation by gastrointestinal (git) microorganisms. in this article, anaerobic oxalate catabolism in gut bacteria is reviewed, and the possible use of these bacteria as probiotics for treating kidney s ...201020602988
enteric oxalate elimination is induced and oxalate is normalized in a mouse model of primary hyperoxaluria following intestinal colonization with oxalobacter.oxalobacter colonization of rat intestine was previously shown to promote enteric oxalate secretion and elimination, leading to significant reductions in urinary oxalate excretion (hatch et al. kidney int 69: 691-698, 2006). the main goal of the present study, using a mouse model of primary hyperoxaluria type 1 (ph1), was to test the hypothesis that colonization of the mouse gut by oxalobacter formigenes could enhance enteric oxalate secretion and effectively reduce the hyperoxaluria associated ...201021163900
factors related to colonization with oxalobacter formigenes in u.s. elucidate the determinants of oxalobacter formigenes colonization in humans.201121381959
efficacy and safety of oxalobacter formigenes to reduce urinary oxalate in primary hyperoxaluria.background: primary hyperoxaluria (ph) is a rare genetic disease, in which high urinary oxalate (uox) cause recurrent kidney stones and/or progressive nephrocalcinosis, often followed by early end-stage renal disease, as well as extremely high plasma oxalate, systemic oxalosis and premature death. oxalobacter formigenes, an anaerobic oxalate degrading bacterium, naturally colonizes the colon of most humans. orally administered o. formigenes (oxabact) was found to significantly reduce urine and p ...201121460356
oxalobacter colonization in the morbidly obese and correlation with urinary stone risk.objectives: to establish the baseline preoperative prevalence of oxalobacter formigenes (of) colonization in a cohort of obese patients scheduled for roux-en-y gastric bypass (rygb) and determine the effect of of colonization on urinary oxalate excretion. it has been proposed that loss of of colonization after rygb may contribute to the development of hyperoxaluria. methods: adult patients scheduled to undergo rygb were requested to provide a stool specimen and 24-hour urine collection before su ...201121529902
impact of dietary calcium and oxalate, and oxalobacter formigenes colonization on urinary oxalate excretion.purpose: enteric colonization with oxalobacter formigenes, a bacterium whose main energy source is oxalate, has been demonstrated to decrease the risk of recurrent calcium oxalate kidney stone formation. we assessed the impact of diets controlled in calcium and oxalate contents on urinary and fecal analytes in healthy subjects who were naturally colonized with o. formigenes or not colonized with o. formigenes. materials and methods: a total of 11 o. formigenes colonized and 11 noncolonized subje ...201121575973
reduction of plasma oxalate levels by oral application of oxalobacter formigenes in 2 patients with infantile oxalosis.the spectrum of primary hyperoxaluria type i is extremely heterogeneous, ranging from singular to recurrent urolithiasis and early end-stage renal disease (esrd). in infantile oxalosis, the most devastating form, esrd occurs as early as within the first weeks of life. no kidney replacement therapy sufficiently removes endogenously overproduced oxalate. however, curative combined liver-kidney transplant often is impracticable in small infants. oxalobacter formigenes (o formigenes), an anaerobic o ...201121705122
oxalate and sucralose absorption in idiopathic calcium oxalate stone better understand intestinal oxalate transport by correlating oxalate and sucralose absorption in idiopathic calcium oxalate stone formers. oxalate has been hypothesized to undergo absorption in the large and small intestine by both paracellular and transepithelial transport. sucralose is a chlorinated sugar that is absorbed by paracellular mechanisms.201121676449
Oligomeric state of the oxalate transporter, OxlT.OxlT, the oxalate transporter of Oxalobacter formigenes, was studied to determine its oligomeric state in solution and in the membrane. Three independent approaches were used. First, we used triple-detector (SEC-LS) size exclusion chromatography to analyze purified OxlT in detergent/lipid micelles. These measurements evaluate protein mass in a manner independent of contributions from detergent and lipid; such work shows an average OxlT mass near 47 kDa for detergent-solubilized material, consist ...201121866906
re: reduction of plasma oxalate levels by oral application of oxalobacter formigenes in 2 patients with infantile oxalosis. 201122078622
the construction of an oxalate-degrading intestinal stem cell population in mice: a potential new treatment option for patients with calcium oxalate calculus.about 80% of all urological stones are calcium oxalate, mainly caused by idiopathic hyperoxaluria (ih). the increased absorption of oxalate from the intestine is the major factor underlying ih. the continuous self-renewal of the intestinal epithelium is due to the vigorous proliferation and differentiation of intestinal stem cells. if the intestinal stem cell population can acquire the ability to metabolize calcium oxalate by means of oxc and frc transgenes, this will prove a promising new thera ...201121892601
oral antibiotic treatment of helicobacter pylori leads to persistently reduced intestinal colonization rates with oxalobacter formigenes.oxalobacter formigenes (of) may play a protective role in preventing calcium oxalate stones. this is the first prospective study to evaluate the effect of antibiotics on of colonization. intestinal colonization by of is associated with reduced urinary oxalate excretion. exposure to antibiotics may be an important factor determining rates of colonization.201122017284
quantitative analysis of colonization with real-time pcr to identify the role of oxalobacter formigenes in calcium oxalate urolithiasis.the objective of the study was to quantitatively measure the number of oxalobacter formigenes (o. formigenes) colonizations in the gastrointestinal tract in calcium oxalate-forming patients with real-time polymerase chain reaction (pcr). calcium oxalate-forming patients (n: 27) were included in the study. serum calcium, sodium, potassium, urea and creatinine levels, as well as 24 h urine levels of calcium and oxalate were measured. the numbers of o. formigenes colonies in stool samples were dete ...201222215293
presence of oxalobacter formigenes in the intestinal tract is associated with the absence of calcium oxalate urolith formation in dogs.the incidence of calcium oxalate (caox) urolithiasis in dogs has increased steadily over the last two decades. a potential mechanism to minimize caox urolithiasis is to reduce enteric absorption of dietary oxalate by oxalate-metabolizing enteric bacteria. enteric colonization of oxalobacter formigenes, an anaerobe which exclusively relies on oxalate metabolism for energy, is correlated with absence of hyperoxaluria or caox urolithiasis or both in humans and laboratory animals. we thus hypothesiz ...201222223029
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