Publications

childhood trachoma in a nonendemic area. danish trachoma patients and their close contacts, 1963 to 1973.	during ten years of study of chlamydia trachomatis eye infections, trachoma was diagnosed in 14 danish patients with onset during childhood. clinical findings in the eye were characteristic of classical trachoma. the infecting c trachomatis immunotype was identified in all but one case. at the time of diagnosis, seven patients were still children (6 to 10 years of age), three were teenagers, and four were adults. in five young girls the disease was extremely severe. delay in proper diagnosis and ...	1978	633586
an improved method for demonstrating the growth of chlamydiae in tissue culture.		1978	634058
chlamydia trachomatis endocarditis.	a case of infective endocarditis due to chlamydia trachomatis immunotype f is reported. multiple negative blood cultures were a major deterrant from the initial clinical diagnosis of infective endocarditis. postmortem ultrastructural identification of chlamydia in the aortic valve vegetation led to an intensive retrospective study of retrieved serum samples utilizing microimmunofluorescent tests. likewise an unusual echocardiographic finding was discovered to be the ultrasonic visualization of a ...	1978	637003
chlamydia trachomatis as possible cause of peritonitis and perihepatitis in young women.	of 11 young women with acute peritonitis proved by laparoscopy, seven of whom also had perihepatitis, nine had serological evidence of recent infection with chlamydia trachomatis; in five of these nine patients high antibody titres to chlamydiae were found without laboratory evidence of gonococcal infection, while the other four had evidence of simultaneous gonococcal infection. c trachomatis may play an important part in peritoneal inflammation previously attributed only to gonococci.	1978	638581
chlamydial infection of the urethra in men.	chlamydia trachomatis was isolated from the uretha of 125 (52%) of 238 men with non-gonococcal urethritis (ngu). repeat isolation attempts in 155 of these patients were successful in eight men in whom results had been negative on the initial visit, but they were unsuccessful in eight men who initially had had positive cultures. we must assume that with our present isolation techniques we are missing, at any single visit, at least 9% of chlamydial infections. c. trachomatis was also found in 32 ( ...	1978	638714
the antimicrobial susceptibility of chlamydia trachomatis in cell culture.	the action of 22 antimicrobial agents against the sa2f strain of chlamydia trachomatis has been studied by the use of a simple cell culture technique. tests for bactericidal activity were undertaken with some of the agents, and latency of infection was demonstrated. the susceptibilities of 10 clinical strains of c. trachomatis and of sa2f to oxytetracyline, erythromycin, and spectinomycin in cell culture were found to be identical.	1978	638716
immunity to vaginal reinfection in female guinea pigs infected sexually with chlamydia of guinea pig inclusion conjunctivitis.	guinea pig boars were inoculated intraurethrally with the chlamydial agent of guinea pig inclusion conjunctivitis (gpic). at the heights of their urethral infections, they were caged with sows in estrus. whereas some of the sows had not been previously exposed to gpic agent, others had received an intravaginal inoculation 5 to 8 weeks earlier. those sows for which infected boars provided the first exposure were challenged by intravaginal inoculation 5 to 8 weeks later. vaginal and conjunctival s ...	1978	640729
chlamydial pneumonia in infants.		1978	643017
etiology and treatment of nongonococcal urethritis.	the significant progress of the last decade in determining the etiology of nongonococcal urethritis is reviewed, and current treatments are assessed. convincing evidence that chlamydia trachomatis is the cause of 30-50% of cases of nongonococcal urethritis has been developed by many groups from isolation data, serologic studies, urethral inoculation of monkeys, and studies of postgonococcal urethritis. other evidence that c. trachomatis is a urethral pathogen is that its selective eradication ...	1978	644417
infection of the uterine cervix with chlamydia trachomatis.	for identification of those variables in the history and in the clinical and routine laboratory examination that are most likely to indicate infection of the uterine cervix with chlamydia trachomatis, 284 women attending a venereal disease clinic were studied, were studied, of whom 58 (20.4%) yielded the organism from the cervix. women with chlamydial cervical infection showed no distinctive symptoms. although associations were found between the presence of c. trachomatis and cervical discontinu ...	1978	649988
incidence and treatment of chlamydia trachomatis genital infection in belfast.		1978	659090
more than meets the eye.		1978	660834
non-specific (non-gonococcal) urethritis.	a report is made of a small study of ureaplasmas and chlamydias in 32 cases of non-specific urethritis. erythromycin was used as a therapeutic agent and found to be reasonably effective.	1978	661709
chlamydia pneumonitis.		1978	661852
contrast of glycogenesis and protein synthesis in monkey kidney cells and hela cells infected with chlamydia trachomatis lymphogranuloma venereum.	glycogen metabolism of monkey kidney (llc-mk-2) cells and hela 229 cells infected with a chlamydia trachomatis lymphogranuloma venereum 440 l (lgv) was studied. the growth cycle of lgv in both host cells was similar; however, a greater number of infectious organism developed intracellularly and were released into the medium during lgv infection of hela 229 cells than mk-2 cells. a rapid infection accompanied by a high rate of glycogen synthesis and a short period of accumulation was found in gel ...	1978	669815
[chlamydia peritonitis: a disease of young females].	serological evidence of recent infection with chlamydia trachomatis was found in 9 of 11 young women with acute peritonitis or perihepatitis proved by laparoscopy. high antibody titres to chlamydiae without laboratory evidence of gonococcal infection were present in 5 of these 9 patients, while the other 4 had evidence of simultaneous gonococcal infection. c. trachomatis may play an important part in peritoneal inflammation previously attributed only to gonococci.	1978	675196
chlamydia trachomatis in non-specific urethritis.	chlamydia trachomatis was isolated from 58.5% of 159 patients with non-specific urethritis (nsu) using irradiated mccoy cell cultures. patients with persistent chlamydia-positive nsu remained chlamydia-positive each time they were examined before treatment and patients with chlamydia-negative nsu remained chlamydia-negative during the course of the illness. neither the duration of symptoms of urethritis nor a history of previous urethritis affected the chlamydial isolation rate significantly. of ...	1978	678958
[transient hypercalcemia associated with reiter's syndrome in patients treated by chronic dialysis].		1978	682235
antichlamydial antibody in tears and sera, and serotypes of chlamydia trachomatis isolated from schoolchildren in southern tunisia.	a predominance of tric serotype a has been isolated from schoolchildren in a population in southern tunisia with severe hyperendemic trachoma. the serotyping results correspond precisely with the serological findings in patients' tears and sera. geometric mean titres of serum or tear antibody in defined populations or areas can thus give a useful indication of the prevalent serotypes. collection of tear fluids on sponges is a more practical method than collection by filter paper strips and gives ...	1978	687547
[chlamydia trachomatis in gynecologic outpatients].		1978	688932
isolation techniques of chlamydia trachomatis from patients with nonspecific urethritis.		1978	689228
in vitro susceptibility of 30 strains of chlamydia trachomatis to rosamicin.	a total of 13 of 30 clinical isolates of chlamydia trachomatis were susceptible in vitro to 0.01 mug of rosamicin per ml. only two of these strains were susceptible to tetracycline or erythromycin at this level. the results suggest that rosamicin may be useful for the treatment of chlamydial urethritis.	1978	708027
urethral syndrome associated with chlamydial infection of the urethra and cervix.		1978	709069
role of chlamydia trachomatis in non-acute prostatitis.	the possible role of chlamydia trachomatis in non-acute prostatitis was investigated by cultural and serological techniques in a study of 53 adult males. c. trachomatis was isolated from the urethra of only one of the 53 patients and from none of the 28 specimens of prostatic fluid from the same patients. by means of a modified microimmunofluorescent test, serum chlamydial igg antibodies at a titre of 1/64 or greater, or igm antibodies at a titre of 1/8 or greater, or both were detected in six o ...	1978	709348
effect of cortisol on the growth of chlamydia trachomatis in mccoy cells.	the number of intracytoplasmic inclusions of chlamydia trachomatis produced in mccoy cell monolayer cultures infected with a constant inoculum of a recently isolated genital strain was compared in cultures of untreated replicating cells and in monolayers which had been incubated in the presence of cortisol at initial extracellular concentrations between 0.0001 and 100 microgram/ml. the effect of adding cortisol was dependent on its concentration, on the time of addition to the tissue culture med ...	1978	711342
prediction of efficacy of antimicrobial agents in treatment of infections due to chlamydia trachomatis.	although chlamydia trachomatis is readily eradicated by systemic therapy in patients with acute urethritis, systemic therapy is less satisfactory in treatment of chronic trachoma. the activities of antimicrobial agents against c. trachomatis in cell cultures when the antimicrobial agents are added 1 hr after the c. trachomatis (minimal inhibitory concentration [mic]) predicts efficacy of the drugs in the treatment of urethritis but does not necessarily predict efficacy in the treatment of chroni ...	1978	712119
nonspecific urethritis: its current status.		1978	722006
examination of men with nongonococcal urethritis and their sexual partners for chlamydia trachomatis and ureaplasma urealyticum.	chlamydia trachomatis was recovered from 39 (52%) of 75 men who had nongonococcal urethritis and from 28 (37%) of their sexual partners. of the partners of men with chlamydia-positive nongonococcal urethritis, 64% excreted chlamydia, compared with 8% of the partners of men with chlamydia-negative nongonococcal urethritis. in contrast, an apparently sexual mode of transmission was not observed with ureaplasma urealyticum. rates of recovery of u. urealyticum from men with nongonococcal urethritis ...	1978	725708
[ocular pathology in northern africa].		1978	741115
experimental infection of the chimpanzee urethra and pharynx with chlamydia trachomatis.	an isolate of chlamydia trachomatis obtained from a man with nongonococcal urethritis was used to produce experimental urethral and pharyngeal infections in chimpanzees. after urethral inoculation of 8 x 10(1) inclusion-forming units (ifu), infections were established in three of three animals; urethral discharges developed in two. the infections persisted for five to nine weeks. larger inocular (7 x 10(2) and 1 x 10(5) ifu) produced pharyngeal infections in two animals. the third animal's phary ...	1978	741332
etiologies of postgonococcal urethritis in homosexual and heterosexual men: roles of chlamydia trachomatis and ureaplasma urealyticum.	before treatment for urethral gonorrhea, chlamydia trachomatis was isolated from 18% and ureaplasma urealyticum from 37% of 121 men. c. trachomatis was recovered from none of 18 homosexual men who had gonorrhea and from 22 of 95 heterosexual men who had gonorrhea (p less than 0.05). after treatment with a penicillin, postgonococcal urethritis occurred significantly more often in heterosexual than in homosexual men (p less than 0.002). postgonococcal urethritis developed in all men from whom c. t ...	1978	741335
treatment of chlamydia-positive and chlamydia-negative nonspecific and postgonococcal urethritis.	chlamydial and non-chlamydial nonspecific or postgonococcal urethritis in 132 men was treated with different regimens of chlortetracycline and doxycycline. chlortetracycline 250 mg four times daily for 12.5-18.5 days given to 70 men resulted in a clinical cure of urethritis in 80% of cases (56/70). there was no difference in the cure rate between chlamydia-positive (40) and chlamydia-negative (30) cases. in no instance was the treatment failure, i.e., re-appearance of urethritis, associated with ...	1978	742827
chlamydia trachomatis and pneumonia in infants: report of two cases.	in two cases of pneumonia associated with chlamydia trachomatis in infants the symptoms began in the second week of life and the illness was severest at 4 weeks of age. both infants were afebrile. one had a history of conjunctivitis. both presented with a characteristic staccato cough and tachypnea but little evidence of peripheral airway obstruction. chest roentgenograms showed interstitial and alveolar pulmonary infiltration in hyperexpanded lungs. the serum igm concentrations were markedly el ...	1978	743659
[etiopathogenesis of trachoma. classification and observations].		1977	757799
fifteen-month follow-up study of women infected with chlamydia trachomatis.		1979	758599
ophthalmia neonatorum due to chlamydia trachomatis: a family problem?	the most frequently seen type of infectious ophthalmia neonatorum, inclusion conjunctivitis, is caused by the organism chlamydia trachomatis. this agent is known to be transmitted sexually. until recently, the infections produced by c trachomatis were though to be relatively benign. recent evidence, however, suggests that the organism may produce urethritis and epididymitis in the male; cervicitis, cervical erosions, salpingitis, and puerperal infections in the female; and prematurity and pneumo ...	1979	759548
chlamydiae, cervicitis, and abnormal papanicolaou smears.	cervical abnormalities accompanied by papanicolaou class ii or class iii cytologic results are commonly encountered in gynecologic office practice. chlamydiae are a common cause of genital tract infection, with or without manifest symptoms or signs. an immunofluorescence method was used to determine the presence of antichlamydial antibodies in cervical secretions. eleven of 15 patients in whom such antibodies were found (73.3%) had papanicolaou class ii or class iii smears, in contrast to only 3 ...	1979	760016
[current venereological problems].		1979	760074
laboratory techniques in ocular virology.		1975	773878
the prevention of blindness from trachoma.		1975	775692
genital chlamydial infections.	the isolation of chlamydial trachomatis in sera of patients with gon ococcal urethritis (gu), non-gonococcal urethritis (ngu), post-gonococca l urethritis (pgu) and trachomainclusion conjunctivitis (tric) is discussed. chlamydiae were isolated in 40% of men with ngu, 20-30% with gu and 0-7% of men with symptomatic or microscopic evidence of urethritis. the rates of isolation of chlamydiae in ngu patients were significantly higher than in controls (p less than .001). the sexual tr ansmitabilit ...	1976	775980
[ultrastructural study of the trachoma infected conjunctiva].		1975	781768
simplified serological test for antibodies to chlamydia trachomatis.	three-hundred sixty sera from unselected patients attending two london venereal disease clinics were examined by a microimmunofluorescence test. eleven egg-grown serotypes of chlamydia trachomatis and the so-called "fast" strain sa2(f) were used as antigens. of the 360 sera tested, 119 (33%) reacted to a titer of 1:16 or above with at least one antigen. of these positive sera, over 50% cross-reacted with all 12 serotypes, and 95.5% reacted with sa2(f) in addition to other antigenic types. it is ...	1976	783191
inclusion blennorrhea: a case report.	the case described here represents the first laboratory-confirmed case of inclusion blennorrhea at the mayo clinic since laboratory isolation of chlamydia trachomatis was instituted in 1974. treatment with a sulfonamide preparation proved effective. further aspects of the diagnosis and treatment of inclusion blennorrhea are discussed.	1976	785121
non-specific urethritis. a placebo-controlled trial of minocycline in conjunction with laboratory investigations.	the results of a double-blind therapeutic trial on 81 men suffering from non-specific urethritis (nsu) show that minocycline was more effective than a placebo. before treatment chlamydia trachomatis was isolated from 31 per cent. of the men, ureaplasmas from 58 per cent., and mycoplasma hominis from 7-5 per cent. there is evidence that chlamydiae are a cause of urethritis. however, after minocycline therapy improvement in the clinical response of patients from whom only ureaplasmas were isolated ...	1976	786440
hemolysis-in-gel test for demonstration of chlamydia antibodies.	sheep erythrocytes were coated with antigens of a strain of chlamydia trachomatis serotype d. chlamydial antibodies in sera from patients with salpingitis or pneumonia were demonstrated by passive hemolysis in agarose gel.	1976	791967
[present-day characteristics of diagnosis of trachoma].		1975	798392
comparative susceptibility of eleven mammalian cell lines to infection with trachoma organisms.	eleven mammalian cell lines, hela 229, hela m, hep-2, ft, bhk-21, vero, mk-2, mpk, l-wo5a2, mccoy, and l-929, were tested for their susceptibility to infection with trachoma strains tw-3 (type c, ocular origin) and uw-5 (type e, genital origin). all the cell layers were pretreated with diethylaminoethyl-dextran before inoculation of the organisms, and the inocula were centrifuged onto the cell layers. hela 229 was found to be the most sensitive to infection as determined by inclusion counts. the ...	1975	809479
chlamydia trachomatis immunotype j.	a new immunotype j is proposed for a group of chlamydia trachomatis strains which are related to trachoma type c in the microimmunofluorescence typing test. ten immunologically identical strains have been identified from four separate areas of the world. the strains were either isolated from the genital tract or from eye infection originating from the genital tract. they grow readily in hela 229 cell culture but poorly in egg culture. whereas two-way cross-reactions were found between types c an ...	1975	810514
chlamydial infection of the male baboon urethra.	two adult male baboons (papio cynocephalus) were infected by urethral catheter with a type d strain of chlamydia trachomatis isolated from a male patient with nongonococcal urethritis. chlamydial organisms were shed from the urethra for about 90 days and serum antibody developed. intraurethral re-inoculation of homologous and heterologous (type i) strains of chalmydia, 4 and 11 months later, resulted in relatively shorter periods of infection of less than 15 days. the antibody titres and type-sp ...	1975	811318
chlamydial infection of the male urethra.	urethral specimens from 477 men were collected with endourethral swabs and examined for chlamydia trachomatis by cell culture on mccoy cells pretreated with idoxuridine. of these men, 141 had gonococcal urethritis, 262 non-gonococcal urethritis (ngu), and 74 showed no evidence of urethritis. of 118 men with heterosexually acquired gonococcal urethritis, thirty (25 per cent.), and of 23 men with homosexually acquired gonococcal urethritis, five (22 per cent.), yielded c. trachomatis from the uret ...	1976	816416
the lack of effect of ampicillin plus probenecid given for genital infections with neisseria gonorrhoeae on associated infections with chlamydia trachomatis.	forty-six men were successfully treated with a single oral dose of ampicillin (2 g) plus probenecid (1 g) for urethral infections with neisseria gonorrhoeae. chlamydia trachomatis was isolated from cultures of cells obtained from 11 of these men both before and after treatment; c. trachomatis was isolated from one man before but not after treatment and from three men after but not before treatment. no isolates were obtained from the remaining 31 men either before or after treatment. of the 15 pa ...	1976	816978
the owl monkey (aotus trivirgatus) as an animal model in trachoma research.	the owl monkey, aotus trivirgatus, in contrast to other species of nonhuman primates, was shown to be susceptable to infection with strains of chlamydia trachomatis. it responded to experimental infection with a severe, acute, inflammatory reaction of short duration. monkeys which recovered from infection were resistant to reinfection for more than 6 months and resistance was not strain specific. eye secretion antibody titers correlated well with resistance to subsequent challenge. these studies ...	1976	828229
respiratory-tract colonization and a distinctive pneumonia syndrome in infants infected with chlamydia trachomatis.	to learn if chlamydia trachomatis causes in young infants a distinctive penumonia characterized by chronic, afebrile course, diffuse lung involvement and elevated serum immunoglobulins g and m, 47 black infants four to 24 weeks of age were examined for nasopharyngeal shedding of c. trachomatis and serum immunofluorescent antibody to lymphogranuloma venereum type i. nasopharyngeal c. trachomatis was found in 18 of 20 with the pneumonia syndrome, two of 15 with various other illnesses and 10 of 12 ...	1977	831128
serologic diagnosis of lymphogranuloma venereum by counterimmunoelectrophoresis with a chlamydia trachomatis protein antigen.	previously a protein antigen was identified which was common to members of the species chlamydia trachomatis and to which antibody could be demonstrated in human sera by two-dimensional immunoelectrophoresis. the antigen has been purified by immunoadsorption chromatography, and an exploration undertaken to determine whether the detection of antibody to this antigen by counterimmunoelectrophoresis would be useful for the diagnosis of c. trachomatis infections. antibody was found in 43 of 45 (96%) ...	1977	839065
nongonococcal urethritis: the role of chlamydia trachomatis.		1977	842992
severe persistent inclusion conjunctivitis in a young child.	a 14-month-old girl had inclusion conjunctivitis although there had been no signs or symptoms that required medical attention in her first year. by 2 1/2 years of age, the child had extensive pannus and corneal scarring that severely reduced vision. the infection was caused by a genital strain of chlamydia trachomatis, tric type e, that was probably acquired at birth. although genitally transmitted chlamydial strains normally cause a self-limiting inclusion conjunctivitis in areas where trachoma ...	1977	848548
chlamydial infection of the urogenital tract in promiscuous and non-promiscuous women.	chlamydia trachomatis infection of the urogenital tract of women presumed to be non-promiscuous, and in presumably promiscuous women attending a special clinic in manchester was studied. two hundred female members of hospital staff, who formed the non-promiscuous group, were found to have a 1% incidence of chlamydial infection. this compared with an incidence of 26% among 200 women attending the clinic. among the clinic patients, chlamydial infection was significantly linked with the presence of ...	1977	858067
chilamydia trachomatis infection in patients with acute salpingitis.	we examined the prevalence of chlamydia trachomatis in the cervix and the fallopian tubes of patients with acute salpingitis. cycloheximide-treated mccoy cells were used as the growth medium. for purposes of comparison, women with infections confined to the lower genital tract and women without signs of genital infections were also studied. c. trachomatis was isolated from the cervix in 19 of 53 patients with acute salpingitis, in one of 18 lower-genital-tract infections and in none of 12 withou ...	1977	859544
the etiology of nongonococcal urethritis in men attending a venereal disease clinic.	nongonococcal urethritis was identified as a major reason that men attended our venereal disease clinic. the prevalence of several agents that might cause nongonococcal urethritis was determined. attempts were made to isolate gonococci; chlamydiae, ureaplasms urealyticum, trichmonads, candida sp., and corynebacterium vaginale from urethral swabs from 307 men. chlamydiae were recovered from 31% of the 67 men with nongonococcal urethritis compared to only 4% of 86 asymptomatic men without pyuria. ...	1977	867205
isolation of chlamydia trachomatis from the male urethra.	chlamydia trachomatis was isolated from 26% of urethral swabs taken from 509 men with urethritis. the highest yield of 68% was obtained from a selected group of men with nonspecific urethritis (nsu) who had a frank urethral discharge. this is a higher than in previous reports, and is significantly higher than the isolation of c. trachomatis from men with less severe urethritis. the higher yield was similar to c. trachomatis isolation rates reported among patients with severe trachoma in hyperend ...	1977	870145
neonatal conjunctivitis caused by neisseria gonorrhoeae and chlamydia trachomatis.	in a selected group of 103 babies referred with neonatal conjunctivitis neisseria gonorrhoeae was isolated from 11 and chlamydia trachomatis from 33. concurrent infection was present in three. on toddler sibling developed chlamydial conjunctivitis. after treatment c. trachomatis was re-isolated from six babies during the follow-up period. the discharge started one to three days after delivery in only three babies with gonococcal conjunctivitis and at five to eight days in eight babies. one baby ...	1977	871893
urethritis due to chlamydia trachomatis.	ninety-five men suffering from gonococcal urethritis were treated and observed. forty-nine developed postgonococcal non-specific urethritis (pgu). seventeen men were demonstrated to be free from pgu after careful observation; these formed a control group. chlamydia trachomatis was isolated from urethral material from 26 (53%) of the pgu group but from none of the controls. this difference was highly significant (p less than 0-001). it confirms that c. tachomatis is a pathogen in the urethra. the ...	1977	871894
isolation of chlamydia trachomatis from throat and rectum of homosexual men.		1977	871895
chlamydial infection in neonates.		1977	876336
ophthalmia neonatorum associated with maternal chlamydial infections.	an unselected sample of 142 pregnant women had a single cervical culture for c trachomatis at 36 to 40 weeks' gestation. of these women, 18 (12.7%) had positive cultures, and their infants were followed in postoperative fashion. of these 18 infants, eight (44%) developed ophthalmia neonatorum. a combination of cultures and conjunctival smears for giemsa staining and fluorescent-antibody examination for infected cells confirmed the diagnosis in 70% of the infants with conjunctivitis. however, 12 ...	1977	878139
antimicrobial activity of several antibiotics and a sulfonamide against chlamydia trachomatis organisms in cell culture.	minimum inhibitory concentrations of several antibiotics and a sulfonamide for growth of the 15 known immunotypes of chlamydia trachomatis were determined in hela 229 cell cultures. the concentrations for complete inhibition of infectious-organism production were (per milliliter): tetracycline, 0.02 to 0.5 mug; rosamicin, 0.05 to 0.25 mug; erythromycin, 0.1 to 0.5 mug; chloramphenicol, 10 mug; penicillin, 0.02 to 50 u; ampicillin, 0.1 to 50 mug; and sulfisoxazole, 2 to 200 mug. the same concentr ...	1977	883821
survival of chlamydiae after cooling to -196 degrees c.	factors influencing the survival of chlamydiae after freezing were reexamined. from the data presented, it is suggested that preservation of laboratory-grown chlamydiae is best achieved through the use of sucrose as the cryoprotective agent, in the presence of 10% serum. dimethyl sulfoxide and glycerol are more toxic. the period of exposure to sucrose before freezing must be kept as short as possible and be at 4 degrees c rather than at room temperature. the rate of cooling during freezing in su ...	1977	886008
the inactivation of chlamydia trachomatis by chlorhexidine ('hibitane').		1977	903334
limited survey of genital infection by guinea pig inclusion conjunctivitis agent.	cervical or urethral scrapings were collected from 245 guinea pigs that had clinical signs of guinea pig inclusion conjunctivitis (gpic) or were parents of newborn young having clinical signs of gpic. giemsa-stained smears were examined for cytoplasmic inclusion bodies, and samples were passaged in 6-day-old embryonating eggs. complement-fixation tests were performed on 44 samples passaged through eggs in an effort to detect the presence of gpic antigen. unequivocal evidence of chlamydial infect ...	1977	921034
[irradiated cell cultures applied to group a "chlamydiae" isolation (author's transl)].	the irradiated mc coy cell cultures method modified by darougar et al. has been used to investigate the frequency of chlamydiae in non-specific genital tract disease, in reiter's disease and in patients suffering from conjonctivits associated with non-specific urethritis. isolates were obtained from 104 men of the 660 suffering from acute urethritis, and from 18 men of the 67 suffering from conjonctivitis associated with urethritis. fourteen female sexual contacts of these men were tested: chlam ...	1977	921141
bacteriology of the urethra in normal men and men with nongonococcal urethritis.	sixty-nine caucasian males without a previous history of urethritis and who developed nongonococcal urethritis (ngu) and 39 similar men without urethritis (nu) were cultured from the urethra for chlamydia trachomatis, mycoplasma hominis, ureaplasma urealyticum, aerobes, and anaerobes. c. trachomatis infection was proven by culture of serology in 26 (38%) of the ngu group and 1 (3%) of the nu group; the c. trachomatis-negative ngu group had significantly more u. urealyticum (81%) than the c. trac ...	1977	925148
the expanding clinical spectrum of infections with chlamydia trachomatis.		1977	929347
antibiotic susceptibility of chlamydia trachomatis.	the antibiotic susceptibility of chlamydia trachomatis isolates was determined in a tissue culture system. representatives of all currently recognized serotypes of trachoma-inclusion conjunctivitis agents were tested. tetracycline and erythromycin yielded similar results, with 1.0 mug/ml preventing chlamydial replication. rifampin was the most active antibiotic, with 0.25 mug/ml completely suppressing inclusion formation of all strains. fifty percent end points were usually achieved at one-fourt ...	1977	931365
a method for testing the antibiotic susceptibility of chlamydia trachomatis in a cell culture system.		1976	931835
characterization of miniature pig kidney cells and their resistance to chlamydial infection.	a miniature pig kidney cell line has been established from porcine fetuses taken aseptically by hysterectomy and maintained for more than 50 passages in eagle's minimal essential medium containing 10% heat-inactivated newborn calf serum. cell transfers were performed each week. primary and serially passaged cells were found to be highly refractory to infection by chlamydia trachomatis strains tw-3, bour, and lgv 440l and chlamydia psittaci strains meningopneumonitis and 6bc and insusceptible to ...	1976	944002
the inactivation of chlamydia trachomatis by povidone-iodine.		1976	945260
the gay bowel syndrome: clinico-pathologic correlation in 260 cases.	the clinical and pathological findings in a group of 260 homosexual men comprising 10% of a private proctologic practice are reviewed. a clinical pattern of anorectal and colon diseases encountered with unusual frequency in these homosexual patients is termed the gay bowel syndrome. the clinical diagnoses in decreasing order of frequency include condyloma acuminata, hemorrhoids, nonspecific proctitis, anal fistula, perirectal abscess, anal fissure, amebiasis, benign polyps, viral hepatitis, gono ...	1976	946385
differences in physicochemical and antigenic properties of chlamydial strains.	antigenic analysis of chlamydia psittaci, c. trachomatis, and lymphogranuloma venereum (lgv) revealed basic physicochemical differences among the three chlamydial strains. these were manifested in structural, isoelectric points, absorption spectra, and in the characteristics of the chromophobe-containing proteins. the effective period of sonication for c. psittaci and c. trachomatis is around 60 min during which the linkages most susceptible to external sonication forces were broken, releasing a ...	1976	963615
antibodies to two immunotypes of chlamydia trachomatis in individuals with trachoma.	in tunisia (north africa), trachoma remains a common eye disease. most cases are caused by immunotype a of chlamydia trachomatis. in a small proportion of cases (less than 10%), type-specific antibodies to both immunotype a and immunotype b exist in the serum of patients. these types do not crossreact, and occasionally sequential acquisition of antibodies has been demonstrated. thus, individuals in one endemic area of trachoma may be infected with two immunotypes of c. trachomatis. the epidemiol ...	1976	971956
infectivity titration of guinea-pig inclusion conjunctivitis agent in irradiated mccoy cells.	estimation of the infectivity of the agent of guinea-pig inclusion conjunctivitis for irradiated mccoy cells, assayed as inclusion-forming units, was influenced by the age of cells after irradiation, the maturation time of the inclusions, the centrifugal force and the centrifugation temperature. agent passaged through irradiated mccoy cells or guinea-pig conjunctivae showed a greater capacity to infect irradiated mccoy cells without centrifuging than agent grown in a chick embryo. the nature of ...	1976	986419
experimental study of the antitrachoma action of berberine.		1976	992845
on the fine structure of the electrocyte of electrophorus electricus l.	the general ultrastructure of the electrocyte, the basic unit of the electric organs of electrophorus electricus, is analyzed. presented herein are detailed observations of the syncytial surface, its fibrillar coat, invaginations of the plasma membrane and synaptic terminals. using thiéry's method glycogen granules were identified in the syncytial cytoplasm and inside the synaptic terminals, their size and structure being compatible with the muscular origin of the electric organs, to which the f ...	1980	1000580
analytical subfractionation of microsomal fractions from the livers of control and gunn-strain rats.		1976	1001660
mediation of cytotoxic immune responses against human tumor-associated antigens by xenogeneic immune rna.	xenogeneic immune rna (i-rna), extracted from the lymphoid organs of sheep or guinea pigs immunized with human tumor cells, mediated in vitro cytotoxic immune responses that were directed specifically against tumor-associated antigens of human tumor target cells. normal human peripheral blood lymphocytes from healthy donors became markedly more cytotoxic for human tumor target cells after being incubated with i-rna extracted from the lymphoid organs of animals that had been immunized with that p ...	1976	1003510
[role of vitamin d and its metabolites in calcium and phosphate metabolism].		1994	1005260
isolation of chlamydia trachomatis from women attending a clinic for sexually transmitted diseases.	attempts were made to isolate chlamydia trachomatis from the cervix of 300 women attending a clinic for sexually transmitted diseases in leeds. the women were divided into four groups; (1) 130 were consorts of men suffering from non-specific urethritis; (2) 66 were suffering from gonorrhoea, or were consorts of men suffering from this disease; (3) 56 were suffering from other sexually transmitted diseases; (4) 48 had no evidence of std. the overall isolation rate of chlamydia trachomatis was 20% ...	1976	1009420
[course and outcome of infiltrative pulmonary tuberculosis in various conditions of the bronchial tree].		1985	1011755
[significance of retrospective studies of fluorograms in diagnosis of pulmonary carcinoma].		1985	1011756
[relationship of the biological effect of radiation to the area of irradiated body surface].	the dependece of radiation injury of piglets on the area of irradiated body surface (v 40 kv, eeff 17 key, 1 10 ma per tube, additional filter 0.1 mm a1, delta 1/2 0.08 mm a1, source--skin distance 30 cm, r 504 r/min, radiattion dose 200 r) was studied. the biological effect was evaluated with respect to the clinical, hematological and biochemical changes in the animal body. the data were obtained that indicated burn disease in the irradiated piglets, severity of which increased with an increase ...	1976	1011787
analysis of "gluten-free"foods for trace amounts of gluten using gel electrophoresis.		1985	1011798
metaphyseal osteopathy (hypertrophic osteodystrophy) in growing dogs. a clinical study.		1976	1011799
effects of moderate recreational activities on the aerobic work capacity of middle-aged women.		1985	1011808
serum alkaline phosphatase and glutamic oxalacetic transaminase in experimental intestinal ischemia.		1976	1011821
evaluation of the possible role of serum factors in the clearance of endotoxin from blood.		1976	1011822
depression of pancreatic bicarbonate response during endotoxic shock in dogs.		1976	1011823
effect of induced thrombocytopenia on experimental circulatory shock.		1976	1011824
thyroid-stimulating hormone and thyrocalcitonin content in rat thyroid.		1976	1011825
peer and self assessment in undergraduate surgery.		1985	1011826
amylase clearance in acute pancreatitis experimental study in the guinea pig.		1976	1011827