Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| immunoreactive atrial natriuretic peptide in neuronal and glial cells of spontaneously hypertensive rat brain. | neuronal and glial cultures from the hypothalamic-brain stem areas of 1-day-old normotensive wistar-kyoto (wky) and spontaneously hypertensive (sh) rat brains stained positively with atrial natriuretic peptide (anp)-specific antibodies. the endogenous levels of the anp immunoreactivity in wky neuronal and glial cultures were 17.0 +/- 2.2 and 14.3 +/- 2.7 pg/mg, respectively. comparable neuronal and glial cultures from sh rat brains contained a 48 to 70% decrease in the endogenous anp immunoreact ... | 1990 | 2137292 |
| [new developments and findings in the field of opiates, opioids, opiate receptors and complete and partial opiate antagonists]. | the historical development of the application of opiates is reviewed. after the detection and localization of opiate receptors in 1973, the clinical application of these substances has been scientifically and systematically developed. the function of the opiate system, the theory of opiate receptors, the opioid peptides, substance p as well as different opiates and analgesics are discussed in detail. the international trend in recent research efforts is aimed at finding a kappa-receptor specific ... | 2007 | 2168183 |
| reduction of drug accumulation and dna topoisomerase ii activity in acquired teniposide-resistant human cancer kb cell lines. | we have isolated stable teniposide (vm26)-resistant cell lines from human cancer kb cells by stepwise exposure to increasing doses of the drug. at each step, we have purified vm26-resistant cell lines. kb/vm-a, kb/vm-b, kb/vm-1, kb/vm-2, kb/vm-3, and kb/vm-4 showed 3-, 6-, 12-, 16-, 74-, and 95-fold higher resistance to vm26 than did kb. we have further characterized kb/vm-2 and kb/vm-4 which showed about 15- and 100-fold higher resistance to vm26 or etoposide (vp16) than did kb. both vm26-resis ... | 1990 | 2168282 |
| diagnosis of human ehrlichiosis with the indirect fluorescent antibody test: kinetics and specificity. | human ehrlichiosis, an acute febrile illness caused by ehrlichia canis or a closely related rickettsial organism, was first identified in 1986. from 1986 through 1988, sera from 85 patients demonstrated a fourfold rise or fall in antibody titer to e. canis. seven (22%) of 32 patients initially tested during the first week after onset of illness. 17 (68%) of 25 tested during the second week, and all 18 tested during the third week had titers that exceeded the minimum positive titer of greater tha ... | 1990 | 2192013 |
| murine typhus on the northern dalmatian islands, yugoslavia. | the present epidemiological study had the objective to establish whether and to what extent resident islander populations might be affected by the natural foci of murine typhus. to this end, 294 serum specimens were collected during summer and autumn of 1985 from the northern dalmatian islanders, all of which were tested for anti-rickettsia typhi (r. typhi) complement fixing (cf) antibodies. these were detected and confirmed at both stages of the screening, namely during the first stage, conduct ... | 1990 | 2212639 |
| alpha-thalassemia: prenatal diagnosis and neonatal implications. | homozygous alpha-thalassemia major, or bart's hemoglobinopathy, is the most common etiology of nonimmune hydrops in those of oriental descent. the prenatal diagnosis can now be made utilizing dna hybridization technique from fetal cells obtained by either amniocentesis or chorionic villus sampling. a case is reviewed documenting the utilization of dna studies in managing patients known or suspected to have a history of alpha-thalassemia major. | 2007 | 2222628 |
| [nmr-microscopic studies of the condylar cartilage of the temporomandibular joint]. | the objectifying of growth mechanisms of the tmj is very important for orthodontic diagnosis, treatment as well as clinical research. condylar cartilage of the tmj from neonatal pigs was investigated on in vivo preparations by nmr-microscopy. nmr-micro-pictures and histologic slide preparations of condylar cartilage were compared and discussed in connection with its implications for treatment with functional appliances. | 1990 | 2227743 |
| [nmr-microscopic studies of the condylar cartilage of the temporomandibular joint]. | the objectifying of growth mechanisms of the tmj is very important for orthodontic diagnosis, treatment as well as clinical research. condylar cartilage of the tmj from neonatal pigs was investigated on in vivo preparations by nmr-microscopy. nmr-micro-pictures and histologic slide preparations of condylar cartilage were compared and discussed in connection with its implications for treatment with functional appliances. | 1990 | 2227743 |
| s-100 immunoreactivity identifies a subset of hair cells in the utricle and saccule of a fish. | certain hair cells of fish exhibit strong immunoreactivity to an s-100 antibody. by their spatial locations in the utricle and saccule, these hair cells appear to possess a relatively short kinocilium and a roughly ovoid cell shape. in the utricle, these cells are predominantly located in the striola. in the saccule, these cells are found within the central area of the epithelium. in both of these epithelia the strongly immunoreactive hair cells coincide with the locations of hair cells possessi ... | 2007 | 2228790 |
| air sampling for legionella. | 1990 | 2232037 | |
| rolling chair sign. | 2007 | 2241609 | |
| leukocyte chemoattractant cytokines of the epidermis. | the constitutive production of interleukin-1 alpha-like material in normal human epidermis, its inflammatory properties, and the mechanism of its inflammatory action are briefly reviewed. the isolation of interleukin-8 from psoriatic lesions, its in vitro production, and leukocyte chemoattractant properties are also described. available evidence suggests that interleukins-1 and -8 are inflammatory cytokines of major potential importance in the induction of leukocyte infiltrates in human skin. | 1990 | 2258626 |
| immunization of cattle (bos indicus x bos taurus) against hyalomma anatolicum anatolicum using antigens derived from tick salivary gland extracts. | studies were conducted on 41 cross-bred (bos taurus x bos indicus) calves which were less than 1 year old. three types of salivary gland antigens (sg ag) viz. sg ag-i (whole), sg ag-ii (supernatant) and sg ag-iii (sediment), prepared from the ixodid tick, hyalomma anatolicum anatolicum, were used for immunizing these calves. the calves were divided into five groups. the first three groups were immunized with sg ag-i, -ii and -iii with freund's complete adjuvant (fca), respectively. the fourth gr ... | 1990 | 2276870 |
| hypoglycemia, hormones and cytokines in fatal meningococcal septicemia. | a unique case report with sequential measurements of the plasma concentrations of glucoregulatory hormones, interleukin-6 and tumor necrosis factor during development of hypoglycemia in fatal meningococcemia is presented. hormonal explanations for hypoglycemia like hyperinsulinemia or defective hypoglycemic counter-regulation were excluded. plasma concentrations of interleukin-6 and tumor necrosis factor were skyhigh. the putative relation between cytokines and hypoglycemia in sepsis is discusse ... | 2008 | 2292658 |
| lipid soluble antioxidants preserve rabbit corneal cell function. | the survival time of rabbit corneal endothelial cells in isolated perfused cornea is extended dramatically by the addition of oxygen free radical scavengers. lipid soluble antioxidants were found to be more effective than water soluble non-enzymatic antioxidants in extending the survival time. the ultrastructural appearance of endothelial cells treated with vitamin e was compared with controls. vitamin e treated endothelial cells retained normal appearance up to 12h, but without vitamin e, break ... | 1990 | 2335108 |
| cloning and nucleotide sequence of a cdna encoding the antifungal-protein of aspergillus giganteus and preliminary characterization of the native gene. | 1990 | 2374718 | |
| endotoxin-induced uveitis in the rat: a hypothesis for preferential involvement of the anterior uvea. | endotoxin-induced uveitis (eiu) was produced in lewis rats by footpad injection of salmonella endotoxin. protein and cells were measured both in the aqueous humor and in the cerebrospinal fluid (csf) in order to examine if the inflammation was strictly limited to the anterior uvea. eiu was also induced in fischer and brown norway rats and the inflammation was compared among the three strains. although the function and structure of the choroid plexus is very similar to the ciliary body, no signs ... | 1990 | 2384004 |
| rickettsiae and hosts. | protective immunity to rickettsia tsutsugamushi in a murine model is dependent upon the development of cell mediated immunity, as demonstrated by lymphocyte transfer, production of lymphokines and -interferon by thymus-derived lymphocytes, activation of macrophages by lymphokines and demonstration of delayed-type hypersensitivity response following exposure to these organisms. infection of mice with small numbers of rickettsia typhi inoculated by a peripheral route leads to a more complex patter ... | 1985 | 2408453 |
| [interaction of local anesthetics with secretory cells at the membrane level]. | 1985 | 2408715 | |
| mechanisms of immunity to infection with typhus rickettsiae: infected fibroblasts bear rickettsial antigens on their surfaces. | as with any immune response to infectious organisms, both antibody and t cell-mediated immune responses to infection with rickettsia typhi require the appropriate presentation of rickettsial antigens to immunocompetent cells. considering the obligate intracellular nature of rickettsiae, the exact mechanisms by which lymphocytes and macrophages encounter and respond to rickettsial antigens may depend on certain aspects of pathogenesis and on the availability of organisms or their antigens to cell ... | 1985 | 2415459 |
| [antigenic structure of the rickettsiae]. | 1985 | 2418607 | |
| prevalence of antibodies to legionella species in a series of patients in israel. | a collection of serum specimens from 77 patients at various hospitals or clinics in israel was used to determine the usefulness of the enzyme-linked immunosorbent assay (elisa) with a multivalent antigen for the detection of legionella antibodies. rickettsial infection rather than legionellosis was suspected in most of these patients. the multivalent antigen was derived from legionella pneumophila serogroups 1-6, l. bozemanii wiga, and l. micdadei tatlock. a preliminary test of the multivalent a ... | 1986 | 2419278 |
| increase of enkephalin and decrease of substance p immunoreactivity in the dorsal and ventral striatum of the rat after midbrain 6-hydroxydopamine lesions. | unilateral 6-hydroxydopamine lesions of the mesostriatal dopaminergic system in the rat resulted in a decrease of substance p-immunoreactivity in the ventral striatum, and in a heterogeneously distributed increase of enkephalin-immunoreactivity in the dorsal and ventral striatum and the globus pallidus. the respective decrease and increase are caused by a lower or higher staining intensity of the peptidergic fibers, whereas no changes were found in the cell bodies. | 1987 | 2440523 |
| heterogeneity of cd4-positive human t-cell clones which recognize the surface protein antigen of rickettsia typhi. | immunity to the typhus group of rickettsiae is largely dependent on the effector function of several classes of t lymphocytes, including those which produce gamma interferon. since the surface protein antigen (spa) derived from typhus group rickettsiae has been shown to be an effective immunogen in animal models, human t-cell clones specific for the spa of rickettsia typhi were isolated and tested for their antigenic specificity, as well as for their ability to produce gamma interferon. eighteen ... | 1989 | 2466795 |
| [physiology of the continence organ before and following pouch-anal anastomosis]. | 2008 | 2474969 | |
| sensitivity, specificity, and cost-effectiveness of the sensitive thyrotropin assay in the diagnosis of thyroid disease in ambulatory patients. | the sensitivity and specificity of two sensitive thyrotropin assays were compared with those of other standard thyroid function tests in 544 ambulatory subjects who were clinically euthyroid, thyrotoxic, or hypothyroid. both sensitive thyrotropin assays had the highest sensitivity and specificity (95%/89% and 92%/95%), following by estimated free thyroxine (t4) level (82% and 94%), calculated free t4 index (78% and 93%), and free triiodothyronine index (86% and 88%). sensitivity of the two thyro ... | 1989 | 2493228 |
| production of antibody to and cellular localization of erythrocyte-sensitizing substance from rickettsia rickettsii. | antibodies to rickettsia rickettsii erythrocyte-sensitizing substance (ess) were raised in rabbits by using a derivatized ess. the resulting antibodies reacted with r. rickettsii and cross-reacted with rickettsia conorii, a member of the spotted fever group rickettsiae, but did not react with rickettsia typhi, a member of the typhus group rickettsiae, legionella bozemanii, or proteus vulgaris ox19 or ox2. immunoblot analysis indicated that ess was present in more than one fraction and that the m ... | 1989 | 2497137 |
| histopathology and immunohistologic demonstration of the distribution of rickettsia typhi in fatal murine typhus. | an 81-year-old woman had chills, fever, nausea, vomiting, and epigastric pain. on day 3 she had hematuria and was treated with trimethoprim-sulfamethoxazole. on day 5 she had a cough, hypotension, anemia, azotemia, and elevated hepatic enzyme levels. her condition deteriorated with thrombocytopenia, anuria requiring dialysis, edema, and hypoalbuminemia. treatment with chloramphenicol and doxycycline was started on day 10. by day 11, she was in hypotensive shock; on day 12 she had seizures and di ... | 1989 | 2499181 |
| detection of murine typhus infected fleas with an enzyme-linked immunosorbent assay. | an enzyme-linked immunosorbent assay (elisa) for the detection of rickettsia typhi antigen in homogenates of pooled or individual laboratory infected fleas is described. the assay uses a double sandwich technique, employing a pool of monoclonal antibodies to capture the antigen and a hyperimmune rabbit serum for antigen detection. using pools of r. typhi infected xenopsylla cheopis, ctenocephalides felis, and leptopsylla segnis, the sensitivity of the elisa was compared with direct fluorescent a ... | 1989 | 2499204 |
| [detection of typhi antibodies by latex agglutination]. | a latex test for immunodiagnosis of murine typhus, using erythrocyte-sensitizing substance from rickettsia prowazekii absorbed to latex particles, has been developed. the test was evaluated with a total of 234 healthy person and non-typhus patient sera, 89 single and 63 paired typhus patient sera. the positive rate was 92.1% for paired and 80.9% for single sera from patients with typhus. the test gave results consistent with those given by the microimmunofluorescence (micro-if) and microagglutin ... | 1989 | 2500317 |
| line blot and western blot immunoassays for diagnosis of mediterranean spotted fever. | the line blot, a new immunoassay in which antigens are placed on nitrocellulose as narrow lines, was evaluated for its sensitivity and specificity relative to the microimmunofluorescence assay for the diagnosis of mediterranean spotted fever (msf). the line blot assay was only slightly less sensitive and less specific than the microimmunofluorescence assay for detection of immunoglobulin m (igm) or igg in 100 serum specimens from 42 patients with msf. no line blot reactions were observed among 5 ... | 1989 | 2506223 |
| seroprevalence of rickettsia typhi and rickettsia conorii infection among rodents and dogs in egypt. | a serological survey of 1813 rodent and 549 dog sera, collected from 1979 to 1986 from animals in 16 egyptian governorates were tested for antibody to rickettsia typhi and rickettsia conorii by the indirect fluorescent antibody test. only three of 82 (4%) sera from rattus rattus collected near aswan had antibody to r. conorii. the prevalence of r. typhi antibody in dog sera was only 0.4% (n = 549) while 25% (n = 547) of rattus norvegicus and 11% (n = 1138) of r. rattus had measurable antibodies. ... | 1989 | 2509729 |
| probe directed at a segment of rickettsia rickettsii rrna amplified with polymerase chain reaction. | in an effort to explore a sensitive taxon-specific detection system for bacteria, we sequenced the 16s rrna from two strains of rickettsia rickettsii, five other rickettsiae, and coxiella burnetti to find a probe site unique to r. rickettsii. we then synthesized a 16-mer that hybridized only to the rrna of r. rickettsii. using a primer complementary to a sequence found only in rickettsial rrna, we then generated a cdna. we amplified the probe site in a 180-base segment of the cdna by using the c ... | 1989 | 2512323 |
| seroprevalence of murine typhus and fièvre boutonneuse in certain human populations in egypt. | a study was conducted between 1984 and 1987 to determine the prevalence of rickettsia typhi and rickettsia conorii infections among humans residing in the nile delta, suez canal area and nile valley of egypt. serum specimens were obtained from garbage and rodent control workers, other unclassified occupational workers, and from patients with fever of undetermined aetiology. all sera were assayed for iga + igm + igg (igamg) antibody mixture and if positive, reassayed for specific igm antibody to ... | 1989 | 2514278 |
| experimental transmission of murine typhus by xenopsylla cheopis flea bites. | transmission of rickettsia typhi to rats by the bites of xenopsylla cheopis (rothschild) fleas was investigated. procedures rigorously excluded the possibility of contamination of the host skin by flea faeces. fleas with r. typhi infection (21-25 days post-infection) which fed through bolting cloth (45 min exposure to ten fleas) transmitted rickettsiae with a success rate of 20%. infective fleas allowed free access to their host for 8 h (10-15 fleas/rat) gave transmission rates of 45-68%. they w ... | 1989 | 2519693 |
| hemodynamic and electrophysiologic effects of amlodipine, a new long-acting calcium antagonist: preliminary observations. | 2008 | 2530867 | |
| diffuse interstitial pneumonitis after pulmonary irradiation for metastatic wilms' tumor. a report from the national wilms' tumor study. | to evaluate the frequency, etiology, and outcome of diffuse interstitial pneumonitis after treatment of children with stage iv (favorable histologic type) wilms' tumor using whole-lung and abdominal radiation therapy, and combination chemotherapy, all cases reported in such patients entered on national wilms' tumor study 3 were reviewed. diffuse interstitial pneumonitis was reported in 13.0% of patients. the etiology was varicella, one patient; pneumocystis carinii, three patients; and unknown, ... | 1989 | 2536290 |
| characterization of cdna clones encoding two putative isoforms of the alpha 1 subunit of the dihydropyridine-sensitive voltage-dependent calcium channel isolated from rat brain and rat aorta. | cdna clones encoding rat brain and rat aorta isoforms of the alpha 1 subunit of the dihydropyridine-sensitive, voltage-dependent calcium channel were isolated and sequenced. these tissue-specific cdna clones share significant amino acid similarity with the rabbit skeletal muscle calcium channel alpha 1 subunit (75% and 66% amino acid identity for rat brain and rat aorta isoforms, respectively). northern analysis revealed transcript sizes of 6.5 and 8.6 kb in aorta and 8.6 kb in brain. | 1989 | 2546805 |
| triazolam. | 2008 | 2570932 | |
| [ki-1 large cell lymphoma with secondary xanthomatous infiltration of the lesions by chemotherapy]. | 2008 | 2575882 | |
| [entomologic situation regarding arbovirus circulation in the guajaibon area]. | the collections of culicidae made in the guajaibón area, north coast of havana province, are analyzed with arbovirologic purposes. the predominance of aedes scapularis in the human bait collections is confirmed. the possibility of arbovirus circulation in the area is suggested. | 1989 | 2577010 |
| in vitro antigen-specific antibody response to the species-specific surface protein antigens of typhus group rickettsiae by human peripheral blood mononuclear cells: generation of an antigen-dependent suppressor t cell. | we defined conditions suitable for in vitro synthesis of rickettsia-specific antibody by human pbmc cultured with the spa of rickettsia typhi or r. prowazekii and without addition of mitogens or polyclonal stimulators. antibody synthesis, as measured by an enzyme-linked immunosorbent assay, was cycloheximide-inhibitable and antigen-specific. pbmc from individuals with prior rickettsial infection made antibody, whereas pbmc from those receiving vaccine or with undetectable levels of serum anti-sp ... | 1985 | 2579151 |
| infection prevention by selective decontamination in intensive care. | 2008 | 2600283 | |
| modification of allergen-induced airway obstruction and airway hyperresponsiveness in an allergic rabbit model by the selective platelet-activating factor antagonist, bn 52021. | allergen challenge of eight ragweed-immunized rabbits elicited a prolonged airway obstruction that was evident during the 6-hour study period. airway responsiveness to histamine was enhanced 24 hours after allergen exposure (geometric mean of the 50% reduction in effective dose [ed50] of dynamic compliance [cdyn] before challenge, 3.46 mg/ml, decreased to 0.52 mg/ml after challenge, p less than 0.01; pulmonary resistance ed50 geometric mean before challenge, 3.50 mg/ml, decreased to 0.65 mg/ml a ... | 1989 | 2600327 |
| do nurses consistently document incontinence? | 1. urinary incontinence is inconsistently documented on medical records of nursing home residents. 2. documentation of urinary incontinence by professional nurses may be improved by changes in organizational factors such as staffing, policy implementation, and staff education. 3. forms that employ cue words for eliminative status show more documentation of continence status than forms that have an open format. 4. evaluation of changes in nursing practice in the nursing home setting can benefit f ... | 2008 | 2600365 |
| the emergence of a health insurance system in a developing country: the case of south korea. | in an attempt to understand the social forces and the economic and political conditions under which new social policies emerge in developing countries, this study outlines factors affecting the introduction of the health insurance system in south korea. the emergence of the south korean health insurance system was influenced by changing labor needs of the industrial sector, increasing social expectations, external and international pressures, increasing medical costs, and class conflict. these p ... | 2008 | 2600387 |
| psychoneurophysiological implications in the pathogenesis and treatment of psoriasis. | 2008 | 2609893 | |
| separation-individuation, aggression and alexithymia in psoriasis. | a psychosomatic study of psoriasis was conducted in order to: 1) assess the level of extra- and intra-aggression (cf. the conflicting results in matussek et al. (1) and lyketsos et al. (2)); 2) point out the presence of alexithymia, i.e. impoverished fantasy life and inability to describe the emotions (cf. some negative results in fava et al. (3)); and 3) explore the interactional variables, connected with the pathology of the separation-individuation process. | 2008 | 2609894 |
| surgical treatment of the iliotibial band friction syndrome. | a selected group of 23 patients underwent surgery for iliotibial band friction syndrome. among the patients presenting with this exertional pain syndrome were runners, football players, and cyclists. diagnosis was clinical since radiographs were negative and an ultrasound examination was positive in only one case, showing an aberrant picture around the lateral femoral epicondyle. although conservative treatment is effective in most cases, an alternative is needed for patients with complaints tha ... | 2008 | 2610280 |
| [clinical study of osteoporosis]. | 2008 | 2614196 | |
| a reappraisal of the terverticillate penicillia using biochemical, physiological and morphological features. i. numerical taxonomy. | three-hundred-and-forty-eight strains representing the major species of terverticillate penicillia, and including representatives of other closely and distantly related species, were included in a numerical taxonomic study. one-hundred characters were derived from morphological features, physiological and biochemical activities and sem micrographs. strains were compared by both gower's coefficient and pattern difference, and clustered using the average linkage algorithm. thirty-seven species or ... | 2008 | 2614375 |
| molecular biology to check patients treated for cml. | 1997 | 2627627 | |
| [papers presented at the 17th conference of the commission on cardiology of the purkinje physiology society. krpácov, 26-28 october 1988]. | 2008 | 2630046 | |
| cachectin/tumour necrosis factor-alpha in the circulation of patients with rheumatic disease. | by means of a sensitive double-antibody radioimmunoassay, cachectin/tumour necrosis factor-alpha (tnf) was measured in sera from 51 patients with rheumatic disease. elevated levels of circulating cachectin/tnf were observed in 46% of patients with rheumatoid arthritis (ra; p less than 0.001 versus blood donors) and in 29% of patients with systemic lupus erythematosus (sle; p less than 0.05 versus blood donors). marked elevation of cachectin/tnf occurred in both ra and sle patients in connection ... | 2008 | 2634628 |
| [measurement of orthodontic appliance force using prototype sensors]. | in introductory remarks the most important biomechanical principles, which are relevant for the research, and conditions which must be satisfied presented in intraoral measuring of orthodontic forces were pointed out. first the aim of the research was defined, and then the investigation of mechanical properties of acrylics as a material for orthodontic appliances were carried out. the type of strain gauges, bonds and measuring system configurations, as well as measuring amplifiers and recording ... | 2008 | 2635572 |
| development of polyclonal and monoclonal antibodies for immunoassay and neutralization of human interleukin-4. | a rabbit antiserum to partly purified recombinant e. coli-expressed human interleukin-4 (il-4) has been produced which neutralizes the t cell growth factor, b cell growth factor, and fc epsilon r2/cd23 inducing activities of il-4. the antiserum demonstrated sufficient avidity to immunoprecipitate labelled cos7-expressed recombinant human il-4. in contrast, rabbits immunized with conjugates of various synthetic il-4 oligopeptides produced antisera which recognized il-4 in both enzyme-linked immun ... | 1989 | 2643668 |
| development of polyclonal and monoclonal antibodies for immunoassay and neutralization of human interleukin-4. | a rabbit antiserum to partly purified recombinant e. coli-expressed human interleukin-4 (il-4) has been produced which neutralizes the t cell growth factor, b cell growth factor, and fc epsilon r2/cd23 inducing activities of il-4. the antiserum demonstrated sufficient avidity to immunoprecipitate labelled cos7-expressed recombinant human il-4. in contrast, rabbits immunized with conjugates of various synthetic il-4 oligopeptides produced antisera which recognized il-4 in both enzyme-linked immun ... | 1989 | 2643668 |
| acceptance of placebo-control trial design by progressive multiple sclerosis patients. the canadian cooperative multiple sclerosis study group. | 2008 | 2648191 | |
| [treatment of cancer of the bladder]. | 2009 | 2653234 | |
| history of medicine in alaska. harriet crocker jackson schirmer, m.d. | 2009 | 2662801 | |
| interrelationships between digestive proteolytic activities and production and quantitation of toxins in pseudomembranous colitis induced by clostridium difficile in gnotobiotic mice. | clostridium difficile pathogenicity is related to in vivo production of toxins, and it is of great interest to detect toxins produced in biological samples. several reports have shown that proteases in stools interfere with immunological methods for quantitation of toxin a. the purpose of this work was to estimate the relationship between the proteases and the c. difficile toxins produced in a gnotobiotic mouse model of pseudomembranous cecitis. cecal proteolytic activities hydrolyzed toxin a, a ... | 1989 | 2680988 |
| the phenomenon and rationale of marked dependence of drug concentration on blood sampling site. implications in pharmacokinetics, pharmacodynamics, toxicology and therapeutics (part ii). | 1989 | 2686884 | |
| failla memorial lecture. the search for critical cellular targets damaged by heat. | 2009 | 2694212 | |
| sce induction by ccnu and pregnancy. | 2009 | 2704378 | |
| the effect of n-3 polyunsaturated fatty acids on lipids, haemostasis, neutrophil and monocyte chemotaxis in insulin-dependent diabetes mellitus. | insulin-dependent diabetes mellitus (iddm) is associated with an increased risk of coronary artery disease (cad). there is some evidence that polyunsaturated fatty acids of the marine n-3 type (n-3 pufa's) may offer protection against cad. we have studied the effect of short-term dietary supplementation with n-3 pufas on lipids, haemostasis, neutrophil and monocyte chemotaxis in 10 patients with iddm. the patients were given 4 g daily of n-3 pufas (fish oil) for 6 weeks and were investigated bef ... | 2008 | 2706043 |
| consumer use of nondispensing professional pharmacy services. | this study attempted to identify and develop an understanding of the use of 13 nondispensing services (ndss) by consumers in the community pharmacy practice setting. a self-administered, postage prepaid questionnaire was sent to 1000 indiana consumers randomly selected from telephone directories. a 45.5 percent response rate was achieved after one original mailing and two follow-ups. most consumers had not used ndss except for advice on nonprescription drugs and advice on minor health problems. ... | 2009 | 2718499 |
| how accurate are faculty evaluations of clinical competence? | to determine the degree and sources of variability faculty evaluations of residents for the american board of internal medicine (abim) clinical evaluation exercise (cex). | 2009 | 2723833 |
| regional differences in the distribution of norepinephrine and epinephrine in human cerebral cortex: a neurochemical study using hplc and electrochemical detection. | we performed neurochemical quantitation of the catecholamines dopamine (da), norepinephrine (ne) and epinephrine (e) and their major metabolites 3,4-dihydroxyphenylacetic acid (dopac), homovanillic acid (hva) and 3-methoxy-4-hydroxyphenylethylene glycol (mhpg) in 22 cortical regions of 6 postmortem human brains. statistical analysis indicated a clear regional difference for ne and e while da and all the metabolites under study are homogeneously distributed over the cortex. these consistent regio ... | 1989 | 2725950 |
| [ct study of the cervical spine with intravenous administration of the contrast medium]. | computed tomography (ct) without contrast medium is largely applied to the study of intervertebral disk pathology in the lumbar spine, but has not been widely accepted in the cervical spine, due to technical and anatomical limitations. for these reasons many neuroradiologists still prefer myelography or myelo-ct. ct may yield better results if combined with iv contrast medium injection, which allows a better visualization of disk herniation. this technique is aimed at enhancing the density of th ... | 2009 | 2727336 |
| [use of a nonionic contrast medium (omnipaque 350) in hysterosalpingography. a comparison with ionic contrast media]. | the comparative adequacy was investigated of a nonionic contrast medium (iohexol) versus the ionic contrast medium usually employed in hysterosalpingography. the contrast radiologic features and the radiodiagnostic possibilities of both cm are definitely good. the nonionic contrast medium diffuses quickly and causes the uterine cavity to expand less than ionic contrast media do, thus allowing a better depiction of mucosal and/or parietal pathology. moreover, nonionic cm allows tubal patency and ... | 2009 | 2727342 |
| angiolymphoid hyperplasia with tissue eosinophilia. | angiolymphoid hyperplasia with eosinophilia is a rare but distinctive clinicopathologic entity. a study of seven cases and review of the literature strongly suggests that both conditions represent a single disease spectrum. the relation of this condition to kimura's disease is controversial. the descriptive term angiolymphoid hyperplasia with tissue eosinophilia is proposed. | 2002 | 2737805 |
| acute febrile cerebrovasculitis. a non-spotted fever group rickettsial disease. | in december 1985, a patient was seen with an illness that was clinically compatible with the recently described clinical syndrome of acute febrile cerebrovasculitis, including fever, headache, altered mentation, multifocal neurologic signs, and cerebrospinal fluid pleocytosis. an extensive medical evaluation failed to reveal a cause, until, retrospectively, she was shown to have antibodies to rickettsia typhi. detailed serologic analysis with enzyme immunoassays and protein immunoblots indicated ... | 1989 | 2742443 |
| amyloid neuropathy in light chain multiple myeloma. | we describe a 73-year-old man with peripheral neuropathy and light chain lambda-type myeloma. a sural nerve biopsy showed the typical neuropathological picture of amyloid neuropathy. with the present case we first demonstrate amyloid deposits in peripheral nerves during light chain multiple myeloma and stress the importance of amyloidosis in the development of peripheral neuropathy. | 1989 | 2743653 |
| phylogenetic diversity of the rickettsiae. | small subunit rrna sequences have been determined for representative strains of six species of the family rickettsiaceae: rickettsia rickettsii, rickettsia prowazekii, rickettsia typhi, coxiella burnetii, ehrlichia risticii, and wolbachia persica. the relationships among these sequences and those of other eubacteria show that all members of the family rickettsiaceae belong to the so-called purple bacterial phylum. the three representatives of the genus rickettsia form a tight monophyletic cluste ... | 1989 | 2753854 |
| comparative sequence analysis of a genus-common rickettsial antigen gene. | the genes encoding the 17-kilodalton genus-common antigen have been cloned and sequenced from rickettsia conorii, rickettsia prowazekii, and rickettsia typhi. compared with the r. rickettsii sequence, this sequence had a high degree of homology within the coding and control regions (r. conorii, 99.8%; r. prowazekii, 88.1%; r. typhi, 88.7%). the 5' flanking regions, including the promoter and the transcription initiation sites, were extremely well conserved for all four species, suggesting that c ... | 1989 | 2768201 |
| human aldehyde dehydrogenase: coenzyme binding studies. | the binding of nadh and nad+ to the human liver cytoplasmic, e1, and mitochondrial, e2, isozymes at ph 7.0 and 25 degrees c was studied by the nadh fluorescence enhancement technique, the sedimentation technique, and steady-state kinetics. the binding of radiolabeled [14c]nadh and [14c]nad+ to the e1 isozyme when measured by the sedimentation technique yielded linear scatchard plots with a dissociation constant of 17.6 microm for nadh and 21.4 microm for nad+ and a stoichiometry of ca. two coenz ... | 1989 | 2775711 |
| opening remarks of president fernando e. agrait on the occasion of the 50th anniversary of the cayo santiago macaque colony. | 1989 | 2780954 | |
| [left ventricular pressure-volume diagram determined by forward and backward formatting of radionuclide ventriculography and analog pressure data]. | pressure-volume (pv) loop is of great value for the assessment of left ventricular (lv) function, but its clinical application has been limited by methodological complexity. a new system was developed to make accurate loop with simplified procedure, and was applied to clinical and interventional study. the system constitutes of a mobile gamma camera, a poly-amplifier and a data processor (gms-550u, toshiba medical) installed in cardiac catheterization labo for simultaneous raw data handling and ... | 2009 | 2786583 |
| [single photon emission computed tomography by using n-isopropyl-p-[123i]-iodoamphetamine and 99mtc-hexamethyl propyleneamine oxime in a patient with herpes simplex encephalitis]. | single photon emission computed tomographies (spects) by using n-isopropyl-p-[123i-imp]-iodo-amphetamine (123i-imp) and 99mtc-hexamethyl propyleneamine oxime (99mtc-hm-pao) were serially performed in a 70 yrs. old male with herpes simplex encephalitis (hse), and the chronological changes of accumulations were studied. accumulations of both 123i-imp and 99mtc-hm-pao increased initially, and then decreased with the stage of hse being advanced. the sequential appearance of the lesion in hse with 12 ... | 2009 | 2786584 |
| cyclosporin a inhibits activation-induced cell death in t-cell hybridomas and thymocytes. | one mechanism by which the immune system develops the ability to discriminate self from nonself is the deletion of autoreactive t-cell clones during thymic maturation. the drug cyclosporin a (csa) has been shown to interfere with this process, allowing the escape of normally 'forbidden' t-cell clones and the appearance of autoimmune disease. recently, it has been demonstrated that immature thymocytes undergo programmed cell death (apoptosis) upon activation via the t-cell receptor. a similar phe ... | 2009 | 2786609 |
| [general proposals of the training programs in subspecialties in gynecology and obstetrics]. | the article presents the outlines of training programs in subspecialties in gynecology and obstetrics as gynaecological oncology, reproductivity and gynaecological endocrinology, maternal-fetal medicine and gynaecological urology. the program should be discussed and evaluated by scientific gynaecological associations, the centre for postgraduate training and approved of by the ministry. | 2007 | 2792854 |
| elevation of factor vii activity and mass in young adults at risk of ischemic heart disease. | the northwick park heart study found that elevation of factor vii in middle-aged subjects was an independent risk factor for subsequent ischemic heart disease. the present study was designed to determine whether factor vii elevation is present at a younger age and whether zymogen or activated factor vii is responsible for this elevation. a group of 20 asymptomatic first degree relatives (mean age 34.9 years) of patients with premature ischemic heart disease were compared with 15 age-matched norm ... | 2009 | 2794283 |
| determination of the seroprevalence of human immunodeficiency virus infection in gravidas by non-anonymous versus anonymous testing. | from february 16, 1988 to july 15, 1988, a prospective study was undertaken at the university of illinois hospital in chicago to do the following: 1) determine the seroprevalence of human immunodeficiency virus (hiv) infection among our gravid patients, 2) test the hypothesis that methodical counseling would elicit a more thorough recounting of risk factors, and 3) test the hypothesis that those patients who self-identify risk factors represent only a fraction of hiv-positive gravidas. after edu ... | 1989 | 2797632 |
| role of adenosine in the gastric blood flow response to pentagastrin in the rat. | we tested the hypothesis that the increase in gastric mucosal blood flow during pentagastrin-stimulated acid secretion in the rat is mediated partly by endogenously generated adenosine. in in vivo microscopic studies, topical 10(-5) to 10(-3) m adenosine dose-dependently dilated the submucosal arterioles, the vessels that control mucosal blood flow. the adenosine receptor antagonist 8-phenyltheophylline, significantly reduced adenosine's vasodilatory response. an adenosine analog with a high a2 ... | 1989 | 2810111 |
| role of adenosine in the gastric blood flow response to pentagastrin in the rat. | we tested the hypothesis that the increase in gastric mucosal blood flow during pentagastrin-stimulated acid secretion in the rat is mediated partly by endogenously generated adenosine. in in vivo microscopic studies, topical 10(-5) to 10(-3) m adenosine dose-dependently dilated the submucosal arterioles, the vessels that control mucosal blood flow. the adenosine receptor antagonist 8-phenyltheophylline, significantly reduced adenosine's vasodilatory response. an adenosine analog with a high a2 ... | 1989 | 2810111 |
| respiratory distress in a cat. | 1989 | 2815529 | |
| respiratory distress in a cat. | 1989 | 2815529 | |
| a rapid fluorometric method for semiautomated determination of cytotoxicity and cellular proliferation of human tumor cell lines in microculture. | a fluorometric method for the determination of cellular growth and cytotoxicity of human tumor cell lines in 96-well microculture plates is described. the assay is based on the combined use of the dna-binding dye hoechst 33342 and the fluorogenic substrate fluorescein diacetate (fda). hoechst 33342 undergoes a dramatic enhancement of fluorescence when specifically intercalated with cellular dna, whereas the fda fluorescence is dependent on cellular hydrolysis of the non-fluorescent substrate int ... | 1989 | 2817793 |
| intravascular synovial sarcoma. | a biphasic synovial sarcoma occurring in the wall of a pathologically thickened femoral vein was diagnosed in a 34-year-old woman. this sarcoma was resected together with removal of a thrombus. a local recurrence was seen 5 years later, but the patient is alive and well 11 years after the first operation. immunohistochemical evaluation revealed cytokeratin and epithelial membrane antigen in a portion of the tumor cells, as are typically seen in synovial sarcoma. this case shows that so-called sy ... | 2009 | 2820861 |
| nicotinic and m1-, m2-muscarinic cholinergic control of acth response to insulin-induced hypoglycaemia in man. | the possible mediation of muscarinic and/or nicotinic-cholinergic receptors in the response of acth to insulin-induced hypoglycaemia was evaluated in 18 normal men. subjects were tested with the insulin (0.15 u/kg) tolerance test (itt) in basal conditions and in the presence of the m1- and m2-muscarinic antagonist atropine (600 micrograms iv just before insulin injection (time 0) plus 600 micrograms 20 min later in 6 subjects) or the m1-muscarinic receptor blocker pirenzepine (40 mg iv 10 min be ... | 1987 | 2827420 |
| ca2+/calmodulin-sensitive inositol 1,4,5-trisphosphate 3-kinase in rat and bovine brain tissues. | inositol 1,4,5-trisphosphate (ins p3) 3-kinase catalyzes the atp-dependent phosphorylation of ins p3 to inositol 1,3,4,5-tetrakisphosphate (ins p4). ca2+/calmodulin (cam)-sensitivity of ins p3 3-kinase was measured in the crude soluble fraction from rat brain and different anatomic regions of bovine brain. kinase activity was inhibited in the presence of egta (free ca2+ below 1 nm) as compared to ca2+ (10 microm free ca2+) or ca2+ (10 microm free ca2+) and cam (1 microm). ca2+-sensitivity was al ... | 1988 | 2838022 |
| mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated. | mineralocorticoid receptors, both when in tissue extracts and when recombinant-derived, have equal affinity for the physiological mineralocorticoid aldosterone and for the glucocorticoids cortisol and corticosterone, which circulate at much higher concentrations than aldosterone. such receptors are found in physiological mineralocorticoid target tissues (kidney, parotid, and colon) and in nontarget tissues such as hippocampus and heart. in mineralocorticoid target tissues the receptors are selec ... | 1988 | 2845584 |
| molecular biological characterization of equine herpesvirus type 1 (ehv-1) isolates from ruminant hosts. | isolates of equine herpesvirus type 1 (ehv-1) originating from affected antelope and cattle were compared with reference ehv-1 and ehv-4 isolates and were characterized. based on cross-neutralization, dna restriction profiles and blot-hybridization data these isolates could be characterized as ehv-1. one isolate (from an antelope) with a different restriction profile showed significant dna homology with ehv-1, partial homology with ehv-4, and little or no homology with ehv-2 and hsv-1 dnas. blot ... | 1988 | 2849252 |
| a study of viral and rickettsial exposure and causes of fever in juba, southern sudan. | patients presenting at the juba teaching hospital, either with fever of undetermined origin or with a clinical cause of fever, gave evidence of exposure to a wide range of viral and rickettsial agents. serological tests showed high antibody levels to flaviviruses (56.9%) and alphaviruses (29.2%), with lesser levels of bunyamweraviruses (3.8%), rift valley fever (2.3%), and sandfly fever (0.75%). flavivirus exposure was significantly associated with clinical evidence of liver disease; repeated ex ... | 1988 | 2855284 |
| possible role of insulin deficiency and growth hormone in severe retinopathy. | 2010 | 2863521 | |
| snoring and cerebral infarction. | the association of snoring with cerebral infarction was tested in a case-control study of 50 male patients with cerebral infarction and 100 male patients with other disorders. cerebral infarction was significantly associated with habitual (almost always or always) snoring; the risk ratio of cerebral infarction between those who did and did not snore habitually was 10.3 (95% confidence limits 3.5-30.1). the corresponding risk ratio was 2.8 (95% cl 1.3-5.8) for snoring often, almost always, or alw ... | 2009 | 2866387 |
| overdose of cyclobenzaprine, the tricyclic muscle relaxant. | a case of cyclobenzaprine (flexeril) overdose in a 31-year-old woman is presented. the treatment rendered was analogous to treatment protocols implemented for tricyclic overdose. a review of the pharmacology of cyclobenzaprine, as well as the management of patients who overdose on this drug, is presented. | 2007 | 2870671 |
| metabolism of 4,4'-methylenebis(2-chloroaniline) by canine liver and kidney slices. | 4,4'-methylenebis(2-chloroaniline) (mboca) metabolism in canine liver and kidney slices was investigated using hplc to separate the metabolites. liver slices metabolized 5-10% of the 14c-mboca in 60 min and produced seven metabolites resolved by hplc. the major metabolite, representing approximately 80% of the metabolism, was 2-amino-5-[(4-amino-3-chlorophenyl)methyl]-3-chlorophenyl hydrogen sulfate, previously identified as the major urinary metabolite in dogs. an mboca-glucoside was identified ... | 1986 | 2870890 |
| metabolism of 4,4'-methylenebis(2-chloroaniline) by canine liver and kidney slices. | 4,4'-methylenebis(2-chloroaniline) (mboca) metabolism in canine liver and kidney slices was investigated using hplc to separate the metabolites. liver slices metabolized 5-10% of the 14c-mboca in 60 min and produced seven metabolites resolved by hplc. the major metabolite, representing approximately 80% of the metabolism, was 2-amino-5-[(4-amino-3-chlorophenyl)methyl]-3-chlorophenyl hydrogen sulfate, previously identified as the major urinary metabolite in dogs. an mboca-glucoside was identified ... | 1986 | 2870890 |
| use of enzyme immunoassay and nucleic acid hybridization for detecting sindbis virus in infected mosquitoes. | aedes aegypti mosquitoes were inoculated intrathoracically with prototype sindbis virus, held at 26.7 degrees c for from 0-95 h and placed at -70 degrees c. individual mosquitoes were tested for virus by plaque assay in vero cells, for viral rna by nucleic acid hybridization using a cloned cdna probe, and for viral protein by enzyme-linked immunosorbent assay. virus was detected by plaque assay as early as 8 h after infection. sindbis virus rna was detected by nucleic acid hybridization 18 h aft ... | 1987 | 2890652 |