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cat-scratch disease manifesting as unifocal helioid choroiditis. 19989747695
detection of bartonella henselae by polymerase chain reaction in brain tissue of an immunocompromised patient with multiple enhancing lesions. case report and review of the literature.the authors report the first dna-based diagnosis of bartonella henselae cultured from a brain lesion in a patient with acquired immune deficiency syndrome. this human immunodeficiency virus-infected patient presented with altered mental status, fever, and diabetes insipidus. magnetic resonance imaging revealed multifocal parenchymal and leptomeningeal involvement, which was confirmed on studies of tissue biopsy samples. using the polymerase chain reaction and gene sequencing techniques, the auth ...19989761060
disseminated bartonella henselae (cat-scratch disease): appearance of multifocal osteomyelitis with mr imaging. 19989763023
[cat scratch disease: description of a new case]. 19989763751
cat-scratch disease osteomyelitis from a dog scratch.osteomyelitis is a rare manifestation of cat-scratch disease in patients who do not have aids. the clinical presentation and non-specific subacute course of the disease make diagnosis difficult. we present a child with osteomyelitis of a metacarpal following a dog scratch. bartonella henselae was found to be the aetiological agent. the bone healed after treatment with antibiotics. increased awareness and a comprehensive medical history are needed to identify patients with suspected bartonella he ...19989768882
[fever of unknown origin]. 19989773562
identification of brucella by ribosomal-spacer-region pcr and differentiation of brucella canis from other brucella spp. pathogenic for humans by carbohydrate profiles.molecular and chemical characteristics often provide complementary information in the differentiation of closely related organisms. the genus brucella consists of a highly conserved group of organisms. identification of the four species pathogenic in humans (brucella melitensis, brucella abortus, brucella suis, and brucella canis) is problematic for many clinical laboratories that depend primarily on serology and phenotypic characteristics to differentiate species. pcr amplification of the 16s-2 ...19989774568
[down the claws!]. 19989775093
experimental infection of domestic cats with bartonella henselae by inoculation of ctenocephalides felis (siphonaptera: pulicidae) feces.caged cat fleas, ctenocephalides felis (bouché), were fed on 6 cats; 3 cats were injected with 5 x 10(7) colony forming units of bartonella henselae intradermally and 3 cats were injected with an equal volume of saline. after the fleas fed for 4 d, 5 groups of 50 b. henselae-exposed fleas were caged and allowed to feed on 5 cats for 6 d. five cats each were injected intradermally with 1 ml of saline containing 45 mg of feces from b. henselae-exposed fleas. five cats were fed 50 b. henselae-expos ...19989775583
subacute orbital abscess in a four-year-old girl with a new kitten. 19989779778
[determination of anti-bartonella henselae antibody by indirect fluorescence antibody test--comparison of two types of antigen: non-cocultivated b. henselae and cocultivated b. henselae with vero cells].serum anti-bartonella henselae igg and igm antibody titers for the diagnosis of cat scratch disease (csd) were determined by indirect fluorescence antibody (ifa) tests. b. henselae as antigen were harvested either by cocultivating with vero cells (cocultivated b. henselae) or by cultivating without them (non-cocultivated b. henselae). based on the results on 110 healthy adults, cut off values were set at 1:32 for igg, and < 1:20 for igm antibodies. according to these criteria, igg antibody was p ...19989780582
[the microbiology of infectious endocarditis].if streptococci and staphylococci remain the main bacteria responsible for infective endocarditis (80%), the emergence of streptococcus bovis associated with intestinal lesions, the confirmation of the role of coxiella burnetii, and the discovery of the responsibility of bartonella sp in case of negative blood culture endocarditis have been the principal microbiological modifications during the last few years. blood cultures performed under the best technical conditions and the examination and c ...19989781112
cat-scratch encephalopathy. 19989781592
murine model of bartonella henselae infection in the immunocompetent host.bartonella henselae is an emerging pathogen causing cat scratch disease, bacillary angiomatosis, and peliosis hepatis. progress in understanding the pathogenesis of and the immune response to these infections has been limited by the lack of an animal model. following intraperitoneal infection of c57bl/6 mice with b. henselae, organs were cleared of cultivatable bacteria within 6 days. in contrast, b. henselae dna could be detected in liver tissue for at least 3 months. liver tissue showed granul ...19989784568
outer membrane proteins of bartonella henselae and their interaction with human endothelial cells.members of the genus bartonella are unique in that they are bacteria which cause proliferation of microvascular endothelial cells and neovascularization (angiogenesis). the mechanisms by which bartonella henselae causes these processes are unknown. given the importance of surface-exposed determinants in the pathogenesis of many organisms, outer membrane proteins (omps) of b. henselae were identified. enrichment of the outer membrane fraction of b. henselae by sarkosyl treatment of total membrane ...19989790875
bacillary angiomatosis in immunocompromised patients.to report seven cases of bacillary angiomatosis; to evaluate the most useful diagnostic tools; to analyse the clinical and epidemiological features associated with bartonella quintana or bartonella henselae infections.19989792380
seroprevalence of bartonella henselae and toxoplasma gondii infections among pet cats in kanagawa and saitama prefectures.seroprevalence of bartonella henselae and toxoplasma gondii was investigated among 471 pet cats obtained from seven private animal hospitals in kanagawa and saitama prefectures during the period from may 1994 to june 1995. 'furthermore, 67 randomly selected from the 471 serum samples were examined for the feline immunodeficiency virus (fiv) antibody and feline leukemia virus (felv) antigen. the antibody to b. henselae was examined by an indirect immunofluorescent antibody test. t. gondii, fiv an ...19989795899
mutations in bartonella bacilliformis gyrb confer resistance to coumermycin a1.this study describes the first isolation and characterization of spontaneous mutants conferring natural resistance to an antibiotic for any bartonella species. the bartonella bacilliformis gyrb gene, which encodes the b subunit of dna gyrase, was cloned and sequenced. the gyrb open reading frame (orf) is 2,079 bp and encodes a deduced amino acid sequence of 692 residues, corresponding to a predicted protein of approximately 77.5 kda. sequence alignment indicates that b. bacilliformis gyrb is mos ...19989797224
use of the cell division protein ftsz as a means of differentiating among bartonella species.genes coding for homologs of the highly conserved cell division protein ftsz were isolated from bartonella henselae and bartonella quintana, the causative agents of cat scratch disease and trench fever, respectively. dna fragments coding for the ftsz open reading frames (orfs) were cloned into escherichia coli following pcr amplification with primers based on the ftsz sequence of the closely related species bartonella bacilliformis. the amino acid sequences predicted from the cloned b. henselae ...19989801332
western blotting analysis of heat shock proteins of rickettsiales and other eubacteria.heat shock proteins (hsp) of four rickettsia species, three bartonella species, two ehrlichia species, orientia tsutsugamushi and seventeen other eubacterial species were characterized by the enhanced chemiluminescence western blotting (wb) technique with antibodies raised against recombinant hsp from escherichia coli and purified groes from r. typhi. although e. coli dnak and groel have epitopes that are highly conserved among the homologous proteins found in rickettsia, ehrlichia, o. tsutsugam ...19989809424
two different genotypes of bartonella henselae in children with cat-scratch disease and their pet cats.two genotypes (i and ii) of bartonella henselae are involved in cat-scratch disease (csd). lymph node biopsies were taken from 3 children suffering from csd, and blood cultures were obtained from their pet cats. cat-scratch disease was confirmed serologically, histologically and by detection of b. henselae dna in all 3 lymph nodes by pcr. bartonella henselae grew in all cats' blood cultures. the first 2 children were siblings. both children and their pet cats were infected with b. henselae genot ...19989817520
isolated right-sided bartonella quintana endocarditis in an immunocompetent adult.bartonella quintana is a recently recognized cause of culture-negative left-sided endocarditis. we report a case of isolated tricuspid endocarditis caused by b. quintana in a 65-year-old alcoholic man, who also had immune-complex glomerulonephritis. b. quintana was established as the cause of the endocarditis based on serological tests and on failure of extensive efforts to isolate an alternative organism. the patient improved gradually on antibiotic therapy and did not require surgery. to our k ...19989817529
[database on nucleotide sequences used as primers of microorganisms].the data base (db) "primers of microorganisms" for the accumulation and systematization of information on oligonucleotide sequences, used as primers in polymerase chain reaction, has been created. this db includes data on primers for the laboratory diagnostics of 20 bacterial genera (aerococcus, aeromonas, bartonella, borrelia, burkholderia, chlamydia, clostridium, corynebacterium, escherichia, francisella, helicobacter, legionella, listeria, mycobacterium, mycoplasma, salmonella, shigella, stap ...19989825498
characterization of human immunoglobulin (ig) isotype and igg subclass response to bartonella henselae infection.serologic parameters of cat scratch disease (csd) were evaluated by western blot analysis. sera from patients with serologically confirmed csd antigen were screened for immunoglobulin (ig) isotype-specific as well as igg subclass-specific reactivity against bartonella henselae whole-cell antigen. bartonella-negative control sera were used to determine baseline antibody activity. heterogeneous b. henselae-specific igg reactivity with numerous protein bands, ranging from >150 to <17 kda, was obser ...19989826373
a man with fever and lymphadenopathy.a 40-year-old man presented with a three-week history of malaise, nausea, night sweats, decreased appetite, and a 15-lb weight loss. he reported having had diarrhea, occasionally with bright red blood, for the first two weeks and a temperature as high as 39.4 degrees c for the last two weeks. he had not had cough, shortness of breath, wheezing, chest pain, arthralgias, rash, or conjunctivitis. he had not eaten raw oysters or raspberries.19989826954
bartonella tribocorum sp. nov., a new bartonella species isolated from the blood of wild rats.two bartonella strains from blood of two wild rats (rattus norvegicus) living in a rural environment were isolated. these strains were distinct from all previously known bartonella species based on phenotypic and genotypic characteristics. this new species is distinguished by its trypsin-like activity, the absence of the ability to hydrolyse proline and tributyrin, its 16s rrna and citrate synthase gene sequences and by whole-dna hybridization data. this new species, for which the name bartonell ...19989828434
a case of cat scratch disease diagnosed by serologic tests specific for bartonella henselae. 19989833058
[bartonella quintana endocarditis. aortic localization and mitral valve abscess].bartonella quintana is an exceptionally rare cause of endocarditis. the frequency of this condition is increasing and is probably underestimated because of the difficulty in diagnosing. the clinical context is that of socially deprived classes, the agent of transmission of the germ being body lice. the commonest valve affected is the aortic valve. this infection may also give rise to a mitral annulus abscess, as in this particular case. the diagnosis should be suspected in all cases of endocardi ...19989833092
[bartonella endocarditis on native valves. apropos of 2 cases].the authors report two cases of bartonella endocarditis in native valves. the first case was a 15 year old north african girl who lived in poor social conditions and was admitted to hospital with pyrexia and congestive heart failure. investigations revealed massive mitral regurgitation due to ruptured chordae tendinae, vegetations on the pulmonary valve with severe pulmonary hypertension due to persistent ductus arteriosus. after antibiotic therapy, the patient underwent surgery for mitral valve ...19989833093
evidence of reproductive failure and lack of perinatal transmission of bartonella henselae in experimentally infected cats.five female specific pathogen-free (spf) cats inoculated intradermally with b. henselae and bacteremic for 4 weeks, and one cat inoculated with 0.9% nacl, were bred with uninfected spf male cats. the uninfected female became pregnant with one breeding, while three infected cats became pregnant 1-12 weeks later, after repeated breedings. two infected females either did not become pregnant or maintain pregnancies despite repeated breedings. infected cats produced anti-b. henselae igm and igg antib ...19989839873
homologous protection but lack of heterologous-protection by various species and types of bartonella in specific pathogen-free cats.cat-scratch disease (csd) is caused by bartonella henselae, and possibly by b. clarridgeiae. in immuno-compromised persons, b. henselae is one of the agents causing bacillary angiomatosis. domestic cats are the main reservoir of these bacteria, which are transmitted primarily from cat to cat by fleas. possible strategies to prevent the spread of infection among cats are to eliminate flea infestation or to prophylactically immunize cats. in order to develop an appropriate vaccine, it is important ...19989839874
[serologic diagnosis of cat-scratch disease]. 19989842534
therapeutic options for cat-scratch disease. 19989850000
[bartonellosis: i. bartonella henselae].the recent discovery of the bacterium bartonella henselae was mainly due to the development of molecular biology techniques adapted to microbial diagnosis and to the description of new human diseases linked to aids. about 10% of pet cats and 33% of stray cats harbour that bacterium in their blood. in immunocompetent patients, that bacterium is responsible for human cat scratch disease, characterized essentially by a localized lymph nodes enlargement in the vicinity of the entry site of the bacte ...19989853027
bartonella henselae infection from a dog. 19989853451
[other infections (streptococcus pneumoniae, haemophilus influenzae, pseudomonas aeruginosa, salmonella spp., campylobacter spp., nocardia asteroides, rhodococcus equi and bartonella spp.)].people infected with human immunodeficiency virus (hiv) are at increased risk for bacterial infections due to hiv-associated immunologic defects. bacterial infections were found to be, both a predictor of progression to aids and a substantial cause of mortality in pre-aids stages. most bacterial infections are caused by streptococcus pneumoniae, haemophilus influenzae, salmonella spp. and pseudomonas aeruginosa. rhodococcus equi, nocardia spp., campylobacter spp. and bartonella spp. are less com ...19989859621
optic disk edema with a macular star.a 13-year-old boy presented with acute loss of vision in his right eye of 2 weeks' duration. he had a high fever and was ill for several days, then improved but suffered recurrent episodes of sweating and a high fever. ophthalmoscopy of the right eye showed optic disk edema, mild vitreous cells, and minimal exudates in the macula. bartonella henselae titers were positive. a diagnosis of optic disk edema with a macular star secondary to cat-scratch disease was made. the patient was treated with d ...19989862313
bartonella infections: diverse and elusive.children with young cats, hiv-infected patients with low cd4 counts, and lice-infested homeless people are among those with an increased risk. clinical presentation varies with the infecting bartonella species and the host. treatment for cat-scratch disease is supportive; macrolide therapy is an appropriate choice for other bartonella infections.19989866646
bartonella henselae-based indirect fluorescence assays are useful for diagnosis of cat scratch disease. 19989867494
detection of specific cellular immune response to bartonella henselae in a patient with cat scratch disease. 19989868676
bartonella infections: diagnostic and management issues.bartonella species are emerging pathogens. renewed interest in this group of bacteria has been highlighted by the recent description of new species, which are pathogenic for humans (bartonella elizabethae and bartonella clarridgeae), and their association with an increasing number of clinical manifestations, the more prevalent being cat scratch disease, bacillary angiomatosis, and culture-negative endocarditis.199817033388
prevalence of bartonella henselae and bartonella clarridgeiae in an urban indonesian cat population.we studied evidence of bartonella henselae and bartonella clarridgeiae infection in 54 cats living in jakarta, indonesia. by using an indirect immunofluorescence assay, we found immunoglobulin g antibody to b. henselae in 40 of 74 cats (54%). the blood of 14 feral cats was cultured on rabbit blood agar plates for 28 days. bartonella-like colonies were identified as b. henselae or b. clarridgeiae by using restriction fragment length polymorphism analysis and direct sequencing of the pcr amplicons ...19999874661
the gene, iala, associated with the invasion of human erythrocytes by bartonella bacilliformis, designates a nudix hydrolase active on dinucleoside 5'-polyphosphates.iala, one of two genes associated with the invasion of human red blood cells by bartonella bacilliformis, the causative agent of several diseases, has been cloned and expressed in escherichia coli. the protein, iala, contains an amino acid array characteristic of a family of enzymes, the nudix hydrolases, active on a variety of nucleoside diphosphate derivatives. iala has been purified, identified, and characterized as an enzyme catalyzing the hydrolysis of members of a class of signaling nucleo ...19999880487
images in clinical medicine. cat scratch disease. 19999887162
[extraction and characterization of the lipopolysaccharide of bartonella quintana]bartonella quintana has been reported as the cause of trench fever, persistent endocarditis, bacteriaemia and has been isolated with an increasing incidence in clinical specimens from aids patients. one of the main pathogenic factors of gram-negative bacteria, including b. quintana, is the lipopolysaccharide (lps). however, very little information is available on the features of bartonella lps. the aim of the present study was to extract, purify and characterise b. quintana lps. the effect of th ...199912759589
vegetative endocarditis in six cats.between 1990 and 1997 vegetative endocarditis was diagnosed in six neutered cats (three males, three females) aged between 3 and 9 years. two cats were purebred (one persian and one tonkinese), the remaining four being domestic short haired cats. the diagnosis was made using echocardiography (five cases) or at necropsy (one case). concurrent involvement of the aortic and mitral valve was noted in four cats, the aortic valve alone was affected in one case, and the tricuspid valve in another. a li ...199911919032
[cat scratch disease]. 199910635816
isolation of bartonella henselae from a serologically negative cat in bloemfontein, south africa.sera collected from apparently healthy 6-12-month-old cats (n = 31) presented to the society for the prevention of cruelty to animals veterinary clinic in bloemfontein for neutering were tested for antibodies reactive to bartonella henselae (houston-1 strain) by indirect fluorescent antibody testing. whole blood collected from the cats was used in isolation experiments and subsequent identification of bartonella species was based on comparison of the nucleotide base sequence of polymerase chain ...199910855838
[ecological aspects of human pathogens ehrlichia and bartonella].the review presents data on the natural circulation of bartonellas and erlichias with the participation of lice, fleas, mosquitoes, ixodes ticks, as well as rodents, large wild mammals, and domestic animals. it outlines the human infection routes that are mainly associated with the attack of infected carriers and with the contacts with different warm-blooded animals. the risk of bartonellosis spread is evidenced by the data showing that 12.3% of clothes lice collected from homeless individuals i ...199911220997
are bartonella significant emerging pathogens in southern africa? 199910941414
beware what you eat and drink, even while on haart.people infected with hiv who are treated with highly active antiretroviral therapy (haart) are staying healthier for longer than ever before, but they still need to be cautious of exposure to foodborne and waterborne bacteria. the centers for disease control and prevention (cdc) lists several pathogens which can be dangerous to persons with hiv/aids, including mycobacterium avium complex (mac) and cryptococcosis. people with hiv who are infected by these pathogens tend to suffer from more severe ...199911366423
cat-scratch disease causing status epilepticus in children.status epilepticus from cat-scratch encephalopathy is often recalcitrant to usual therapies, causing treatment to focus on critical care management of the patient that may require aggressive interventions, such as continuous pentobarbital administration. we describe two children whose initial clinical presentation of cat-scratch disease was status epilepticus with normal cerebrospinal fluid studies. a history of cat exposure (specifically, kitten and/or fleas), regional lymphadenopathy, and a pa ...19999932833
body lice as tools for diagnosis and surveillance of reemerging diseases.body lice are vectors of three bacteria which cause human disease: rickettsia prowazekii, the agent of epidemic typhus; bartonella quintana, the agent of trench fever; and borrelia recurrentis, the agent of relapsing fever. a recrudescence of body lice is being observed as the numbers of individuals living under social conditions which predispose individuals to infestation have increased. because this phenomenon may lead to the reemergence of infections transmitted by body lice, we aimed to asse ...19999986818
bartonella alsatica sp. nov., a new bartonella species isolated from the blood of wild rabbits.bartonella species are considered as emerging human pathogens, with at least six different species pathogenic or possibly pathogenic for humans. however, little is known about bartonella distribution, species polymorphism and pathogenicity in mammalian species. the objective of this work was to determine the presence, the frequency and the distribution of bartonella species in wild rabbits (oryctolagus cuniculus) caught in warrens in alsace, france. humans may come into contact with wild rabbits ...199910028274
bartonella henselae infection associated with peripapillary angioma, branch retinal artery occlusion, and severe vision loss.to report atypical clinical features of bartonella henselae neuroretinitis treated with combination antibiotics.199910030575
interactions of bartonella henselae with vascular endothelial cells.the emerging human pathogen bartonella henselae has the remarkable capacity to colonise vascular tissues and to stimulate vasoproliferative tumour growth. although the molecular principle of bacterium-induced neovascularisation (angiogenesis) is still unclear, recent studies have indicated a novel mechanism of endothelial colonisation that involves the formation, engulfment and uptake of a large bacterial aggregate.199910047560
bone pain after lymphadenitis. bartonella henselae granulomatous osteitis. 199910048617
cat-scratch disease with paravertebral mass and osteomyelitis.the case of a 9-year-old girl with cat-scratch disease (csd) complicated by development of a paravertebral mass and osteomyelitis is presented. following multiple scratches and inguinal lymphadenopathy, she developed back pain, and imaging demonstrated a paravertebral mass with evidence of osteomyelitis involving vertebra t9. the diagnosis was made on the basis of detection of bartonella henselae by use of molecular techniques on an aspirate from the vertebral column and supportive serology for ...199910064243
[cat-scratch disease: series of 14 cases. the diagnostic usefulness of serology].disease by cat scratch (csd) is a syndrome characterized by regional adenopathies following cat scratch or bite. despite knowing the etiologic agent of the same, there is still controversy in the diagnosis of the syndrome in daily clinical practice.199910069107
detection of bartonella henselae dna by two different pcr assays and determination of the genotypes of strains involved in histologically defined cat scratch disease.cat scratch disease (csd) is a common cause of subacute regional lymphadenopathy, not only in children but also in adults. serological and molecular studies demonstrated that bartonella henselae is the etiologic agent in most cases of csd. amplification of b. henselae dna in affected tissue and detection of antibodies to b. henselae are the two mainstays in the laboratory diagnosis of csd. we designed a retrospective study and investigated formalin-fixed, paraffin-embedded lymph nodes from 60 pa ...199910074515
bartonella koehlerae sp. nov., isolated from cats.two of the 25 bartonella isolates recovered during a prevalence study of bartonella henselae bacteremia in domestic cats from the greater san francisco bay region were found to differ phenotypically and genotypically from all prior b. henselae isolates. these isolates, c-29 and c-30, which were recovered from the blood of two pet cats belonging to the same household, grew on chocolate agar as pinpoint colonies following 14 days of incubation at 35 degrees c in a candle jar but failed to grow on ...199910074535
involvement of host cell tyrosine phosphorylation in the invasion of hep-2 cells by bartonella bacilliformis.we have provided evidence that exposure of human cells to protein kinase inhibitors results in decreased invasion of these cells by bartonella bacilliformis in a dose-dependent manner. preincubation of human laryngeal epithelial cells in the presence of genistein, a tyrosine protein kinase inhibitor, decreased the invasion of these cells by b. bacilliformis significantly. further, exposure of normal human umbilical vein endothelial cells to staurosporine, a potent inhibitor of protein kinase c a ...199910077844
[prevalence of serum igg antibody against bartonella henselae in an asymptomatic japanese population]. 199910077908
cat scratch disease diagnosed by polymerase chain reaction in a patient with suspected tuberculous lymphadenitis.we present a patient diagnosed as having tuberculous lymphadenitis after lymph node biopsy and referred for tuberculous therapy. on review, because of recent cat exposure, she was tested for cat scratch disease (csd), but serological tests for bartonella henselae were negative. however, the diagnosis of csd was confirmed, and tuberculosis excluded, by polymerase chain reaction techniques. this case serves as a reminder that csd may mimic tuberculosis histologically and that sensitive molecular d ...199910078182
the iala invasion gene of bartonella bacilliformis encodes a (de)nucleoside polyphosphate hydrolase of the mutt motif family and has homologs in other invasive bacteria.the product of the iala invasion gene of bartonella bacilliformis has been expressed as a thioredoxin fusion protein. it is a (di)nucleoside polyphosphate hydrolase of the mutt motif protein family with strong sequence similarity to plant diadenosine tetraphosphate hydrolases. it hydrolyses nucleoside and dinucleoside polyphosphates with four or more phosphate groups, always producing an ntp as one product. diadenosine tetraphosphate (ap4a) is the preferred substrate with a km of 10 microm and a ...199910080922
bartonella quintana in body lice collected from homeless persons in russia. 199910081691
[cat scratch disease]. 199910088350
[bartonellosis]. 199910088493
haemobartonellosis in squirrel monkeys (saimiri sciureus): antagonism between haemobartonella sp. and experimental plasmodium falciparum malaria.a hemotropic parasite of the genus haemo bartonella (rickettsial parasite of the family anaplasmataceae) is responsible for latent asymptomatic infection in colony-born saimiri monkeys. indeed, many of these animals develop a patent haemobartonella infection following splenectomy. such patent parasitism is characterized by an intense haemobartonella parasitemia which peaks between days 12 and 14 after removal of the spleen and then decreases to become undetectable between days 25 and 30. during ...199910092473
[bartonella infection in humans].bartonella bacilliformis: among the 3 species of bartonella known to be human pathogens, b. bacilliformis causes carriun's disease, which manifests an acute phase (oroya fever) and a chronic phase marked by benign skin eruption with wart like macules of vascular origin. until 1993, b. bacilliformis was considered to be the only species in bartonella genus. in 1993, species formally in the rochalimaea genus were designated as bartonella species. bartonella quintana: this species causes trench fev ...199910093604
prevalence of bartonella henselae immunoglobulin g antibodies in singaporean cats.bartonella henselae causes several clinical diseases in humans. the most common infection is the classical cat-scratch disease (csd) occurring in immunocompetent and immunocompromised children exposed to newly acquired kittens. this is the first study of b. henselae infection in singaporean cat population.199910093952
[bartonellosis. ii. other bartonella responsible for human diseases].in addition to bartonella henselae, five other bartonella species were involved in human pathology. as for b. henselae, ectoparasites seem to be responsible for the transmission of most or all these bacterial species. b. bacilliformis is responsible for carrion's disease that occurs in some valleys of colombia, ecuador and peru. this disease is transmitted by biting of infected sandflies. the bacterial reservoir is constituted by humans only. that disease occurs either as an acute form with seve ...19999920964
vaccination of cats against emerging and reemerging zoonotic pathogens.many of the emerging infectious agents that threaten the human population are either directly zoonotic or involve animals, rather than humans, as their primary reservoir in nature. vaccination of animals may be an important consideration for control of some of these diseases, and this review has specifically focused on the concept of vaccinating cats in the prevention of infection with t. gondii, b. henselae, and h. pylori. if we return to the considerations that were presented in table iii, t. ...19999890026
[trench fever]. 199910201203
evaluation of human seroreactivity to bartonella species in sweden.among the species that compose the expanding genus bartonella, thus far only b. henselae and b. quintana have reportedly been isolated from humans in europe. to evaluate the prevalence of bartonella infection in sweden, we conducted a retrospective serological examination of 126 human serum samples. these samples were analyzed for antibodies to b. henselae, b. quintana, and b. elizabethae. serum samples from 100 blood donors, who spanned the ages of 20 to 60 and had no apparent clinical signs of ...199910203491
clinical and pathologic evaluation of chronic bartonella henselae or bartonella clarridgeiae infection in cats.human bartonella infections result in diverse medical presentations, whereas many cats appear to tolerate chronic bacteremia without obvious clinical abnormalities. eighteen specific-pathogen-free cats were inoculated with bartonella henselae- and/or bartonella clarridgeiae-infected cat blood and monitored for 454 days. relapsing bacteremia did not correlate with changes in protein profiles or differences in antigenic protein recognition. intradermal skin testing did not induce a delayed type hy ...199910203518
bartonella spp infection as a possible cause of uveitis in a cat.a 6-year-old castrated mixed-breed cat was evaluated because of unilateral anterior uveitis. the cat was seronegative for antibodies to toxoplasma gondii, coronaviruses, and feline immunodeficiency virus, and antigens for felv p27 and cryptococcus neoformans. antibodies to bartonella spp were detected in serum and aqueous humor. the antibody coefficient (c value) for igg antibodies to bartonella spp in the aqueous humor was 4.42; values > 1 suggest ocular production of antibodies and supports a ...199910212684
chronic bartonella quintana bacteremia in homeless patients.infection with bartonella quintana can cause trench fever, endocarditis, bacillary angiomatosis, and peliosis. an outbreak of bacteremia due to b. quintana has been reported among homeless people in seattle, and the seroprevalence is high among homeless people in both the united states and europe. body lice are known to be the vectors of b. quintana.19999895398
expression of inducible nitric oxide synthase in human granulomas and histiocytic reactions.inducible nitric oxide synthase (inos) is required in immune response against infections and is involved in granuloma formation in animals; in murine macrophages, inos is induced by lipopolysaccharide and interferon-gamma. in contrast, the role of inos in human immune response against infections is still questioned, and its expression in granulomas is poorly investigated. using western blotting and immunohistochemistry, we investigated inos expression in human lymph nodes with nonspecific reacti ...19999916929
cat-scratch disease. 19999917765
management of b. henselae neuroretinitis in cat-scratch disease. 19999917766
seroprevalence of bartonella henselae among hiv-1 infected patients in japan. 199910655688
hhv-8 (kshv) is not associated with bacillary angiomatosis.bacillary angiomatosis is a rare pseudoneoplastic angioproliferative lesion occurring in patients with aids. this condition has been associated with bartonella henselae and bartonella quintana infections. human herpesvirus 8 (hhv-8) is thought to be the causative agent of kaposi's sarcoma, a vasoproliferative neoplasm, also commonly found in patients with aids. the presence of hhv-8 in a cohort of patients with bacillary angiomatosis was investigated.199910748868
[seroepidemiology of bartonella henselae infection in hiv-infected patients].bartonella henselae infections are closely related to numerous clinical infections of growing interest in spain. since immunosuppressed patients are a potential risk group for infection by this bacteria, the aim of the present was to study the seroepidemiology of b. henselae infection in a risk group (patients with hiv infection) and in a control group (donors).199910614075
massive hemoperitoneum: a new manifestation of bacillary peliosis in human immunodeficiency virus infection. 199910825061
duke criteria-negative endocarditis caused by bartonella quintana.bartonella spp. were recently recognized as causative agents of culture-negative endocarditis. molecular techniques, such as broad-range pcr, are now available to detect fastidious or slow-growing microorganisms, or those which cannot be cultured. such microorganisms may be responsible for culture-negative endocarditis. alcoholism and homelessness are known risk factors for bartonella quintana endocarditis, even in patients without previous valvular disease. we report a case of b. quintana endoc ...199910885846
culture-positive bartonella quintana endocarditis.a 50-year-old alcoholic man with a 1-year history of pyrexia of unknown origin was admitted with symptoms of endocarditis. large vegetations on his mitral and aortic valve were found on echocardiography. using the bactec 9240 system. bartonella quintana could be grown from two culture sets of blood collected before the start of antimicrobial therapy. this is the first case report of culture-proven bartonella infection in the uk. and is noteworthy because bartonella quintana was detected in conve ...199910219581
[three children with systemic cat scratch disease].three girls with systemic cat scratch disease, aged 10, 13 and 9 years, were reported. they presented a prolonged fever and back pain in the early stage of the disease, and had no regional lymphadenopathy. two of them had hepatosplenic granulomas, one with multiple 5 mm hypoechoic lesions in the liver and spleen, and the other with a single 2.5 cm hypodense lesion in the left hepatic lobe. the latter patient underwent a partial left hepatic lobectomy. all patients had elevated titers of antibodi ...199910222672
disseminated bartonella infection with granulomatous hepatitis in a liver transplant recipient.disseminated infection with bartonella spp with granulomatous hepatitis was diagnosed in a liver transplant recipient presenting with fever of unknown origin. pathological findings on liver biopsy were atypical, with scant granulomas seen only after a second biopsy. the patient responded promptly to antibiotic therapy. infections caused by bartonella spp should be considered in transplant recipients with fever of unknown origin.199910226118
cat-scratch disease encephalopathy: a cause of status epilepticus in school-aged children.we describe 6 school-aged patients who presented with status epilepticus (se) secondary to cat-scratch disease (csd) encephalopathy to alert clinicians to this distinctive clinical entity. the hospital database for admissions during 1 year was reviewed for patients presenting with se; 4 of 5 previously healthy school-aged children with se had csd encephalopathy based on elevated indirect fluorescent antibody titers to bartonella henselae. csd encephalopathy should be included in the differential ...199910228301
serologic response to bartonella henselae in patients with cat scratch disease and in sick and healthy children.indirect fluorescent antibody assay (ifa) is the most reliable test for detecting antibody to bartonella henselae in the diagnosis of cat scratch disease (csd). recently, an elisa test has been proposed, but conflicting results are reported. we compared igg-ifa and igg-igm elisa methods in csd patients and in healthy children. we also tested elisa specificity in a large group of healthy controls and in children with lymphoma-associated lymphadenopathy and with pyogenic lymphadenitis. the elisa p ...199910229038
experimental infection of cotton rats with three naturally occurring bartonella species.the kinetics of infection and humoral immune response of laboratory-bred cotton rats (sigmodon hispidus) challenged with three bartonella spp. recovered from the blood of naturally infected cotton rats captured in georgia (usa) are described. bartonella spp. infection, as determined by bacteremia, occurred in all 18 cotton rats inoculated with live bartonella of each species at either a low dose, 10(3) colony-forming units (cfu's), or high dose, 10(7) cfu. cotton rats inoculated with lower doses ...199910231754
culture of bartonella quintana and bartonella henselae from human samples: a 5-year experience (1993 to 1998).bartonella quintana and bartonella henselae are fastidious gram-negative bacteria responsible for bacillary angiomatosis, trench fever, cat scratch disease, and endocarditis. during a 5-year period, we received 2,043 samples for culture of bartonella sp. we found bartonella sp. to be the etiologic agent in 38 cases of endocarditis, 78 cases of cat scratch disease, 16 cases of bacteremia in homeless people, and 7 cases of bacillary angiomatosis. we correlated the results of positive cultures with ...199910325344
cat-scratch disease simulating a malignant process of the chest wall.cat-scratch disease is a well-known cause of regional adenopathy in immunocompetent children. rarely, patients may present with symptoms simulating a neoplastic disease. the case of a 12-year-old boy with fever, swelling of the chest wall and hepatosplenic nodules is reported. histological analysis of biopsy specimen obtained from the chest wall lesion and the liver revealed granulomatous reaction without malignant cells. serological investigations were positive for bartonella species. the sympt ...199910333124
acute clinical disease in cats following infection with a pathogenic strain of bartonella henselae (lsu16).bartonella henselae is the causative agent of human cat scratch disease as well as several serious sequelae of infections, including bacillary angiomatosis and bacillary peliosis. conflicting reports describe the pathogenesis of b. henselae in the cat. in this study, we characterized a strain of b. henselae termed lsu16. this strain was isolated on rabbit blood agar from a naturally infected 10-month-old female cat during a recurrent episode of bacteremia. the bacterial species was confirmed by ...199910338522
survey of bartonella species infecting intradomicillary animals in the huayllacallán valley, ancash, peru, a region endemic for human bartonellosis.the natural cycle of bartonella bacilliformis remains uncertain, and the suspected existence of animal reservoirs for the bacterium has never been convincingly demonstrated. we conducted a survey of bartonella species infecting intradomicillary animals in a bartonellosis-endemic region of peru, obtaining blood from 50 animals living in the homes of 11 families whose children had recently had bartonellosis. bartonella-like bacteria were recovered from four of nine small rodents included in the st ...199910344656
bartonella henselae and bartonella clarridgeiae infection in domestic cats from the philippines.one hundred seven domestic cats from the philippines were serologically tested to establish the prevalence of bartonella infection. a subset of 31 of these cats also had whole blood collected to tentatively isolate bartonella strains. bartonella henselae and b. clarridgeiae were isolated from 19 (61%) of these cats. bartonella henselae type i was isolated from 17 (89%) of the 19 culture-positive cats. six cats (31%) were infected with b. clarridgeiae, of which four were coinfected with b. hensel ...199910348234
development and evaluation of a polymerase chain reaction assay using the 16s rrna gene for detection of eperythrozoon suis infection.the 16s ribosomal rna (rrna) gene of eperythrozoon suis was amplified using gene-specific primers developed from genbank sequence accession u88565. the gene was subsequently cloned and sequenced. based on these sequence data, 3 sets of e. suis-specific primers were designed. these primers selectively amplified 1394, 690, and 839 base-pair (bp) fragments of the 16s rrna gene from dna of e. suis extracted from the blood of an experimentally infected pig during a parasitemic episode. no polymerase ...199910353353
rats of the genus rattus are reservoir hosts for pathogenic bartonella species: an old world origin for a new world disease?bartonella species were isolated from the blood of 63 of 325 rattus norvegicus and 11 of 92 rattus rattus from 13 sites in the united states and portugal. infection in both rattus species ranged from 0% (e.g., 0/87) to approximately 60% (e.g., 35/62). a 337-bp fragment of the citrate synthase (glta) gene amplified by polymerase chain reaction was sequenced from all 74 isolates. isolates from r. norvegicus were most similar to bartonella elizabethae, isolated previously from a patient with endoca ...199910353885
a case of cat scratch disease masquerading as lymphogranuloma venereum. 199910361925
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