| in vitro activities of telithromycin (hmr 3647) against rickettsia rickettsii, rickettsia conorii, rickettsia africae, rickettsia typhi, rickettsia prowazekii, coxiella burnetii, bartonella henselae, bartonella quintana, bartonella bacilliformis, and ehrlichia chaffeensis. | in vitro activities of telithromycin compared to those of erythromycin against rickettsia spp., bartonella spp., coxiella burnetii, and ehrlichia chaffeensis were determined. telithromycin was more active than erythromycin against rickettsia, bartonella, and coxiella burnetii, with mics of 0.5 microg/ml, 0.003 to 0.015 microg/ml, and 1 microg/ml, respectively, but was inactive against ehrlichia chaffeensis. | 2000 | 10770788 |
| clinical disease in kittens inoculated with a pathogenic strain of bartonella henselae. | to evaluate disease in kittens inoculated with bartonella henselae strain lsu16. | 2000 | 10772100 |
| visceral manifestation of cat scratch disease in children. a consequence of altered immunological state? | a 12-year-old girl with a 2-month history of fever and abdominal pain was admitted to our hospital. ultrasound and ct scans of the abdomen showed multiple hypoechoic lesions of liver and spleen. screening for zoonosis revealed high positive titers to bartonella henselae. t-cell deficiency was demonstrated and remained almost unchanged during a follow-up of 11 months. a review of the literature shows that disseminated visceral affection is a rare presentation of cat scratch disease (csd) in child ... | 2000 | 10782400 |
| rapid identification and differentiation of bartonella species using a single-step pcr assay. | five species of bartonella have been reported to infect humans and cause a variety of diseases that can be difficult to diagnose. four species of bartonella have been reported to infect cats and dogs, and two of these species are considered to be zoonotic pathogens. diagnosis of bartonella infections is hampered by the slow, fastidious growth characteristics of bartonella species. we report on the development of a single-step pcr-based assay for the detection and differentiation of medically rel ... | 2000 | 10790087 |
| bartonella henselae infection as a cause of fever of unknown origin. | fourteen of 41 patients (34%) with a serological diagnosis of bartonella henselae infection were found to have prolonged fever or fever of unknown origin, suggesting that generalized systemic b. henselae infection is not rare in immunocompetent healthy individuals. | 2000 | 10790137 |
| subtyping of uncultured bartonellae using sequence comparison of 16 s/23 s rrna intergenic spacer regions amplified directly from infected blood. | this study aimed to assess the usefulness of a pcr-based approach to the detection and differentiation of bartonella strains in infected blood. the conservation of potential genus-specific pcr primer hybridisation sites within the 16 s/23 s rrna gene intragenic spacer regions of bartonella species was confirmed following sequence analysis of the intragenic spacer regions of four previously untested species. the extent of intra-species variation within the specific amplicons was assessed by compa ... | 2000 | 10799268 |
| bartonella interactions with host cells. | | 2000 | 10804853 |
| cat scratch disease: posterior segment manifestations. | | 2000 | 10811065 |
| prevalence of serologic evidence of cat scratch disease in patients with neuroretinitis. | to determine the prevalence of bartonella henselae seropositivity in patients with a clinical diagnosis of neuroretinitis. | 2000 | 10811077 |
| massive hemoperitoneum: a new manifestation of bacillary peliosis in human immunodeficiency virus infection. | | 1999 | 10825061 |
| bartonella spp. isolated from wild and domestic ruminants in north america. | bartonella species were isolated from 49% of 128 cattle from california and oklahoma, 90% of 42 mule deer from california, and 15% of 100 elk from california and oregon. isolates from all 63 cattle, 14 deer, and 1 elk had the same polymerase chain reaction/restriction fragment length polymorphism profiles. our findings indicate potential for inter- and intraspecies transmission among ruminants, as well as risk that these bartonella spp. could act as zoonotic agents. | 2000 | 10827123 |
| polymerase chain reaction detection of bartonella henselae bacteraemia in an immunocompetent child with cat-scratch disease. | a case of bartonella henselae bacteraemia is reported in an immunocompetent 8-year-old boy with cat-scratch disease. serology to b. henselae, diagnosed by polymerase chain reaction, was positive. dna was extracted from peripheral whole blood and amplified with specific primers targeting the htra gene of b. henselae. a non-isotopic hybridization assay with a species-specific oligonucleotide probe was used to detect the amplified product. conclusion: the polymerase chain reaction can be used for t ... | 2000 | 10834521 |
| isolation in endothelial cell cultures of chlamydia trachomatis lgv (serovar l2) from a lymph node of a patient with suspected cat scratch disease. | an inguinal lymph node, removed from a 21-year-old romanian man suspected of having cat scratch disease, was sent to our laboratory for bartonella culture. lymph node specimens were inoculated on blood-enriched agar and in an endothelial cell culture system using the centrifugation shell vial technique. bacteria were grown in cell monolayers and detected as positive with an anti-bartonella henselae rabbit serum. however, such bacteria were identified as chlamydia trachomatis biovar lgv serovar l ... | 2000 | 10834954 |
| [clinical evaluation of commercial serological test for bartonella infection]. | we evaluated the usefulness of a serological diagnostic kit (bartonella ifa igg, igm; mrl diagnostics) for bartonella henselae infection. of the 110 healthy individuals, 107 (97.3%) were with titers being less than 1:64 for igg antibody to b. henselae, 2 were with titers being 1:64 and 1 with 1:128, igm antibody to b. henselae was negative in all individuals. serological diagnosis of cat scratch disease (csd) using indirect fluorescence antibody (ifa) methods (in-house and diagnostic kit) was ma ... | 2000 | 10835846 |
| endotoxin and nanobacteria in polycystic kidney disease. | microbes have been suspected as provocateurs of polycystic kidney disease (pkd), but attempts to isolate viable organisms have failed. bacterial endotoxin is the most often reported microbial product found in pkd fluids. we assessed potential microbial origins of endotoxin in cyst fluids from 13 pkd patients and urines of pkd and control individuals. | 2000 | 10844606 |
| isolation of bartonella henselae from a serologically negative cat in bloemfontein, south africa. | sera collected from apparently healthy 6-12-month-old cats (n = 31) presented to the society for the prevention of cruelty to animals veterinary clinic in bloemfontein for neutering were tested for antibodies reactive to bartonella henselae (houston-1 strain) by indirect fluorescent antibody testing. whole blood collected from the cats was used in isolation experiments and subsequent identification of bartonella species was based on comparison of the nucleotide base sequence of polymerase chain ... | 1999 | 10855838 |
| bartonella quintana endocarditis in a child. | | 2000 | 10866564 |
| widening of the clinical spectrum of bartonella henselae infection as recognized through serodiagnostics. | the recently improved diagnostics have widened, in children, the spectrum of clinical manifestations recognisable as bartonella henselae infection. we report here the clinical features of 20 (14 males) consecutive children with serologically proved b. henselae infection observed within 12 months in the paediatric department of the university of pisa. the patients had a mean age of 7 years 4 months (range 1.1-14.1 years). all children but one had a history of contact with kittens. clinical manife ... | 2000 | 10867845 |
| the gene encoding the 17-kda antigen of bartonella henselae is located within a cluster of genes homologous to the virb virulence operon. | a bartonella henselae genomic a library was screened with antiserum generated in mice against live b. henselae. one of the immunoreactive clones expressed a 17-kda antigen that was characterized previously as an immunodominant protein of b. henselae. sequence analysis of the recombinant clone, pbhim-2, revealed that the open reading frame (orf) encoding the 17-kda antigen was situated between homologs of virb4 and virb6, two genes that belong to the virb operon. the virb operon has been associat ... | 2000 | 10882236 |
| differentiation of bartonella species by a microimmunofluorescence assay, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and western immunoblotting. | bartonella species can be differentiated by microimmunofluorescence assay, sodium dodecyl sulfate polyacrylamide gel electrophoresis (sds-page), and immunoblotting with murine polyclonal antisera to bartonella henselae, b. quintana, b. elizabethae, and b. bacilliformis. a pairwise comparison on the basis of sds-page protein profiles demonstrated similarity values for proteins of different bartonella species ranging from 28.6 to 86.4%. antigenic relationships revealed by immunoblotting with murin ... | 2000 | 10882662 |
| duke criteria-negative endocarditis caused by bartonella quintana. | bartonella spp. were recently recognized as causative agents of culture-negative endocarditis. molecular techniques, such as broad-range pcr, are now available to detect fastidious or slow-growing microorganisms, or those which cannot be cultured. such microorganisms may be responsible for culture-negative endocarditis. alcoholism and homelessness are known risk factors for bartonella quintana endocarditis, even in patients without previous valvular disease. we report a case of b. quintana endoc ... | 1999 | 10885846 |
| bartonella infection in animals: carriership, reservoir potential, pathogenicity, and zoonotic potential for human infection. | recent observations have begun to support a role for bartonella spp. as animal as well as human pathogens. bartonella spp. are vector-transmitted, blood-borne, intracellular, gram-negative bacteria that can induce prolonged infection in the host. persistent infections in domestic and wild animals result in a substantial reservoir of bartonella organisms in nature that can serve as a source for inadvertent human infection. the prevalence of bacteremia can range from 50 to 95% in selected rodent, ... | 2000 | 10885985 |
| cyclic cd8+ lymphopenia in dogs experimentally infected with bartonella vinsonii subsp. berkhoffii. | until recently, it was presumed that bartonella vinsonii only infected voles, a species of north american rodents. in april of 1993, however, our laboratory isolated a novel subspecies of b. vinsonii (b. vinsonii subsp. berkhoffii) from the blood of a dog diagnosed with vegetative valvular endocarditis. subsequently, based on a seroepidemiologic survey of dogs from north carolina and virginia presenting for a variety of medical problems, we found evidence supporting a potentially important assoc ... | 2000 | 10889298 |
| isolation, sequencing and expression of bartonella henselae omp43 and predicted membrane topology of the deduced protein. | the infection of and interaction of human endothelial cells with bartonella henselae is one of the most interesting aspects of bartonella -associated disease. the gene encoding the 43 kda b. henselae outer membrane protein (omp43) that binds endothelial cells was cloned and sequenced. sequence analysis revealed an open reading frame of 1206 nucleotides coding for a protein of 402 amino acids. analysis of the deduced amino acid sequence shows 38% identity over the entire sequence to the brucella ... | 2000 | 10906262 |
| seroprevalence of bartonella henselae and toxoplasma gondii among healthy individuals in thailand. | the seroprevalence of bartonella henselae and toxoplasma gondii among apparently healthy individuals, mainly blood donors, in thailand was investigated by an indirect fluorescent antibody technique and by a latex agglutination test, respectively. of 163 serum samples examined, 9 (5.5%) were found to be positive for b. henselae-igg, 2 (1.2%) for b. henselae-igm, and 5 (3.1%) for the t. gondii antibody. no significant difference was observed between male and female samples in the serological test ... | 2000 | 10907691 |
| bartonella quintana and urban trench fever. | contemporary bartonella quintana infections have emerged in diverse regions of the world, predominantly involving socially disadvantaged persons. available data suggest that the human body louse pediculus humanus is the vector for transmission of b. quintana. descriptions of the clinical manifestations associated with contemporary b. quintana infections have varied considerably and include asymptomatic infection, a relapsing febrile illness, headache, leg pain, "culture-negative" endocarditis, a ... | 2000 | 10913410 |
| hemin-dependent growth and hemin binding of bartonella henselae. | bartonella henselae causes cat-scratch disease and bacillary angiomatosis peliosis. the bacteria reside in erythrocytes of asymptomatic cats, which represent the natural reservoir for this pathogen. b. henselae is usually grown on blood-enriched media. growth experiments on brucella medium without blood demonstrated that heme compounds are essential for the growth of b. henselae and can completely substitute the addition of blood components. the heme precursor protoporphyrin ix alone, or in comb ... | 2000 | 10913865 |
| infectious exanthems and unusual infections. | invasive disease due to group a beta-hemolytic streptococci (gabhs) can be divided into 3 categories of disease: streptococcal toxic shock syndrome (streptss), necrotizing fasciitis, and other invasive gabhs disease. patients with streptss may have multiorgan failure within hours of presentation. clindamycin and penicillin g should be used in combination for treatment of invasive gabhs disease. the mortality rate for menstrual staphylococcal toxic shock syndrome has decreased with early recognit ... | 2000 | 10916128 |
| [a "diagnosis of goldsmith"]. | | 2000 | 10916845 |
| are bartonella emerging and re-emerging pathogens in southern africa? | | 2000 | 10918880 |
| characterization of bartonella clarridgeiae flagellin (flaa) and detection of antiflagellin antibodies in patients with lymphadenopathy. | cat scratch disease (csd) is a frequent clinical outcome of bartonella henselae infection in humans. recently, two case reports indicated bartonella clarridgeiae as an additional causative agent of csd. both pathogens have been isolated from domestic cats, which are considered to be their natural reservoir. b. clarridgeiae and b. henselae can be distinguished phenotypically by the presence or absence of flagella, respectively. separation of the protein content of purified flagella of b. clarridg ... | 2000 | 10921956 |
| differentiation of pathogenic bartonella species by infrequent restriction site pcr. | infrequent restriction site pcr (irs-pcr) is a recently described dna fingerprinting technique based on selective amplification of restriction endonuclease-cleaved fragments. bartonella isolates associated with human disease and related nonhuman isolates were analyzed by irs-pcr genomic fingerprinting. preparation of dna templates began with double digestion using three different restriction endonuclease combinations. combinations included the frequently cutting endonuclease hhai in conjunction ... | 2000 | 10921969 |
| neuroretinitis associated with cat scratch disease in a child. | | 2000 | 10933777 |
| [update in infectious diseases. part i: epidemiology]. | a number of infectious agents has been newly detected in the last 10 years. climatic changes and migration have been the most important factors in the emergence of new and old infections. additionally, new methods for the detection of dna and rna have played an important role in the detection of agents difficult to culture. relevant new bacterial pathogens are bartonella henselae (cat scratch disease, bacillary angiomatosis), tropheryma whippeli (whipple's disease) and new rickettsiae. newly det ... | 2000 | 10935415 |
| rnase iii processing of intervening sequences found in helix 9 of 23s rrna in the alpha subclass of proteobacteria. | we provide experimental evidence for rnase iii-dependent processing in helix 9 of the 23s rrna as a general feature of many species in the alpha subclass of proteobacteria (alpha-proteobacteria). we investigated 12 rhodobacter, rhizobium, sinorhizobium, rhodopseudomonas, and bartonella strains. the processed region is characterized by the presence of intervening sequences (ivss). the 23s rdna sequences between positions 109 and 205 (escherichia coli numbering) were determined, and potential seco ... | 2000 | 10940010 |
| are bartonella significant emerging pathogens in southern africa? | | 1999 | 10941414 |
| molecular cloning, sequencing, expression, and characterization of an immunogenic 43-kilodalton lipoprotein of bartonella bacilliformis that has homology to nlpd/lppb. | a recombinant clone expressing an immunoreactive antigen of bartonella bacilliformis was isolated by screening a genomic dna library with serum from a patient with the chronic verruga phase of bartonellosis. the clone, pbipim-17, contained a partial open reading frame that expressed an immunoreactive fusion protein. subsequent rescreening of the library by plaque hybridization resulted in the isolation of recombinant clones that contain the entire open reading frame. the open reading frame (orf- ... | 2000 | 10948113 |
| [polymerase chain reaction (pcr) for microbiological diagnosis in refractory infectious keratitis: a clinical study in 16 patients]. | the identification of the causative pathogen in infectious keratitis is possible in only 60% of the cases. the aim of this study was to show if this number increases by the use of pcr. | 2000 | 10949815 |
| natural history of infection with bartonella bacilliformis in a nonendemic population. | an investigation was performed after an outbreak of bartonellosis in a region of peru nonendemic for this disorder. symptoms of acute and chronic bartonellosis were recorded. serological analysis was performed on 55% of the affected population (554 individuals), 77.5% of whom demonstrated previous infection with bartonella bacilliformis. the attack rate of oroya fever was 13.8% (123 cases); the case-fatality rate was 0.7%. the attack rate of verruga peruana was 17.6%. a new specific immunostain ... | 2000 | 10950782 |
| [evaluation of serological response to bartonella henselae by enzyme immunoassay in cat scratch disease]. | the igg and igm titers to bartonella henselae were determined by an enzyme immunoassay (eia). the eia test for detection of igg and igm antibodies to b. henselae concerning csd showed that 8 (40%) of 20 patients with csd had a serum igg antibody titer of 12 eia unit or more and that 5 (25%) patients had a serum igm titer of 12 eia unit or more. totally 12 (60%) of the 20 patients with csd were seropositive for b. henselae. the mean age of igg positive patients were higher than igm positive patie ... | 2000 | 10965658 |
| [cat-scratch disease caused by bartonella quintana in an infant: an unusual presentation]. | this case study reports a typical clinical course of cat-scratch disease (csd) in an infant without epidemiological data and presenting bilateral submandibular lymphadenopathy. the authors describe clinical course, ultrasound images, diagnosis and prognosis. polymerase chain reaction (pcr) detected and identified b. quintana in lymph node samples. b. henselae currently thought to be the causative agent of csd was not detected. the pcr assays for b. quintana and b. henselae should be available fo ... | 2000 | 10967601 |
| interaction of bartonella bacilliformis with human erythrocyte membrane proteins. | intracellular invasion is an important aspect of carrión's disease caused by bartonella bacilliformis. both the hematic and tissue phases of the disease involve the initial attachment of the organism to erythrocytes and endothelial cells, respectively. using two different approaches, preliminary evidence is provided that b. bacilliformis interacts with multiple surface-exposed proteins on human erythrocytes. utilizing western blot analysis, it was demonstrated that the organism binds several bio ... | 2000 | 10968948 |
| extracellular bartonella henselae and artifactual intraerythrocytic pseudoinclusions in experimentally infected cats. | blood, spleen and liver of specific pathogen-free (spf) cats and spf cats experimentally infected with bartonella henselae were examined. using immunohistochemical labeling, no intracellular b. henselae were observed in tissues of any cats, but extracellular b. henselae were detected in tissues of infected cats. pseudoinclusions were detected in erythrocytes of all cats using electron microscopy. | 2000 | 10973702 |
| [familial parinaud oculo-glandular syndrome in cat-scratch disease]. | cat-scratch disease is manifested by subacute, regional lymphadenitis and occurs mainly in children. the causative agent is a pleomorphic, gram-negative bacillus, bartonella henselae carried by asymptomatic cats. parinaud oculoglandular syndrome is the most common ocular manifestation of this disease. it is characterized by unilateral conjunctivitis with polypoid granuloma, usually of the palpebral conjunctiva, and preauricular lymphadenopathy. the diagnosis is supported by a history of exposure ... | 2000 | 10979428 |
| transverse myelitis associated with probable cat-scratch disease in a previously healthy pediatric patient. | we evaluated a pediatric patient for transverse myelitis associated with bartonella henselae infection. there was no adenopathy in our patient, but the diagnosis was made serologically. it is necessary to keep cat-scratch disease in mind even in the absence of typical findings. | 2000 | 10987731 |
| infection of human endothelial cells with bartonella bacilliformis is dependent on rho and results in activation of rho. | bartonella bacilliformis was continuously internalized into human endothelial cells beginning shortly after addition of the bacteria and continuing for at least 24 h after infection in vitro, with a major increase in uptake occurring between 16 and 24 h. preincubation of endothelial cells with c3 exoenzyme, which inactivated intracellular rho-gtpase, blocked internalization of the bacteria. addition of c3 exoenzyme at any time after addition of the bacteria blocked further internalization of bac ... | 2000 | 10992508 |
| transcriptional activation of the htra (high-temperature requirement a) gene from bartonella henselae. | bacterial htra genes are typically activated as part of the periplasmic stress response and are dependent on the extracytoplasmic sigma factor rpoe. a putative promoter region, p1, of the sigma(e)-type heat-inducible promoters has previously been identified upstream of the htra gene of bartonella henselae. further analysis of the htra mrna by primer extension demonstrated that transcription initiates from p1 and a second region downstream of p1. this second promoter region, termed p2, had no seq ... | 2000 | 10992509 |
| [neonatal papular acrodermatitis (gianotti-crosti) and bartonella henselae infection]. | | 2000 | 11003916 |
| bartonella henselae associated uveitis and hla-b27. | to investigate the frequency of hla-b27 in patients with presumed bartonella henselae associated uveitis and to describe the clinical characteristics of hla-b27 positive patients with uveitis and presumed ocular bartonellosis (pob). | 2000 | 11004097 |
| [parotid involvement in cat scratch disease: a differential diagnosis with increased significance]. | bartonella henselae is the causative agent of cat-scratch disease (csd), an inflammatory infection of the lymph nodes. so far, only few cases of atypical manifestations in the head and neck, especially manifestations in the parotid gland have been reported. | 2000 | 11006911 |
| specific and nonspecific enzymes involved in the catabolism of mononucleoside and dinucleoside polyphosphates. | this review concerns enzymes that can degrade nucleoside 5'-tetra- and pentaphosphates (p(4)n and p(5)n) and those that can degrade various dinucleoside polyphosphates (np(3-6)n'). most of these enzymes are hydrolases, and they occur in all types of organisms. certain fungi and protozoa also possess specific np(n)n' phosphorylases. specific p(4)n hydrolases have been demonstrated in mammals and in plants. in yeast, p(4)n and p(5)n are hydrolyzed by exopolyphosphatases. among other hydrolases tha ... | 2000 | 11007995 |
| bartonella henselae, b. quintana, and b. bacilliformis: historical pathogens of emerging significance. | bartonella species were virtually unrecognized as modern pathogens of humans until the last decade. however, identification of bartonella species as the agents of cat-scratch disease, bacillary angiomatosis, urban trench fever, and possible novel presentations of carrion's disease has left little doubt of the emerging medical importance of this genus of organisms. the three primary human pathogenic bartonellae, bartonella bacilliformis (carrion's disease), b. henselae (cat-scratch disease), and ... | 2000 | 11008109 |
| regional lymphadenopathy in cat-scratch disease: ultrasonographic findings. | cat-scratch disease (csd) is considered to be an emerging disease worldwide and is caused by bartonella henselae, a gram-negative bacterium introduced by a scratch or bite of a cat. the most common clinical manifestation is regional lymphadenopathy, but clinical recognition may be difficult, as atypical manifestations may occur. the diagnosis is confirmed with serologic testing and histology is rarely needed. this paper is based on our experience with the use of ultrasonography in the diagnosis ... | 2000 | 11009305 |
| optic disk edema associated with peripapillary serous retinal detachment: an early sign of systemic bartonella henselae infection. | to describe optic disk edema associated with peripapillary serous retinal detachment as an early sign of systemic bartonella henselae infection. | 2000 | 11020412 |
| ocular bartonellosis. | to review recent advances in the basic and clinical biology of bartonella-related eye disease. | 2000 | 11020414 |
| experimental evidence of host specificity of bartonella infection in rodents. | a large number of bartonella species and genetic variants were compared for their ability to cause bacteremia in different rodent species: the cotton rat (sigmodon hispidus), white-footed mouse (peromyscus leucopus), balb/c mouse and wistar rat. experimental data supported field observations that host specificity can occur among certain bartonella species and rodent species. bacteremia could only be readily produced in cotton rats or white-footed mice if the strains used for inoculation were ori ... | 2000 | 11038125 |
| [the niches and pathways of animal pathogens]. | infectious diseases are not a relict of the past but a topical phenomenon determined by complex evolution of the currently existing and constantly changing microbial agents and their hosts. with regard to abundance of species within the microbial kingdom and rate of its changes and development, it is difficult to predict the role of the microbial factor in mortality of humans and animals. the study and generalization of sequential similarities of microbial virulence factors after the completion ... | 2000 | 11039207 |
| pseudoinfectious mononucleosis: a presentation of bartonella henselae infection. | six children presented during one year with clinical features of infectious mononucleosis, but with laboratory findings of leucocytosis with neutrophilia, increased erythrocyte sedimentation rate, and hypergammaglobulinaemia. serology for epstein-barr virus, cytomegalovirus, adenovirus, and toxoplasma gondii was negative, while anti-bartonella henselae igm with high igg titre (>/=1/1024) was present in all. all children had contact with kittens. no specific treatment was administered and all rec ... | 2000 | 11040157 |
| rickettsia prowazekii and bartonella henselae: differences in the intracellular life styles revisited. | within the alpha subdivision of proteobacteria, the arthropod-borne human pathogens rickettsia prowazekii and bartonella henselae provide examples of bacteria with obligate and facultative intracellular life styles, respectively. the complete genome sequence of r. prowazekii has been published, whereas the sequencing of the b. henselae genome is in its final stage. here, we provide a brief overview of a comparative analysis of both genomes based on the delineated metabolic properties. the relati ... | 2000 | 11045918 |
| [peripheral lymphadenopathy in childhood--recommendations for diagnostic evaluation]. | enlargement of peripheral lymph nodes most commonly caused by a local inflammatory process is frequently seen in childhood. the aim of the present study was to analyze the most common causes of peripheral lymphadenopathy and to develop a simple algorithm for the primary diagnostic evaluation of peripheral lymph node enlargement in this age group. | 2000 | 11048289 |
| immune aspects of bartonella. | bartonella species have been recognized as important human pathogens only recently. until the early 1990s, this genus was represented by one species, bartonella bacilliformis. the recent identification of other bartonella species as the agents of cat-scratch disease and bacillary angiomatosis has left little doubt of their emerging importance as opportunistic human pathogens. over the last decade, extensive research has been performed on bartonella species, resulting in an explosion in our knowl ... | 2000 | 11052646 |
| [when cats scratch]. | | 2000 | 11059029 |
| coyotes (canis latrans) as the reservoir for a human pathogenic bartonella sp.: molecular epidemiology of bartonella vinsonii subsp. berkhoffii infection in coyotes from central coastal california. | bartonella vinsonii subsp. berkhoffii was originally isolated from a dog suffering infectious endocarditis and was recently identified as a zoonotic agent causing human endocarditis. following the coyote bite of a child who developed clinical signs compatible with bartonella infection in santa clara county, calif., this epidemiological study was conducted. among 109 coyotes (canis latrans) from central coastal california, 31 animals (28%) were found to be bacteremic with b. vinsonii subsp. berkh ... | 2000 | 11060089 |
| serodiagnosis of bartonella bacilliformis infection by indirect fluorescence antibody assay: test development and application to a population in an area of bartonellosis endemicity. | bartonella bacilliformis causes bartonellosis, a potentially life-threatening emerging infectious disease seen in the andes mountains of south america. there are no generally accepted serologic tests to confirm the disease. we developed an indirect fluorescence antibody (ifa) test for the detection of antibodies to b. bacilliformis and then tested its performance as an aid in the diagnosis of acute bartonellosis. the ifa is 82% sensitive in detecting b. bacilliformis antibodies in acute-phase bl ... | 2000 | 11060108 |
| pathogenic mechanisms of bartonella quintana. | bartonella quintana is an epi- and intracellular gram-negative rod responsible for both acute and chronic clinical manifestations. we review the literature about pathogenic mechanisms of b. quintana and discuss our data. our efforts to clarify bartonella quintana pathogenesis run on two parallel tracks. the first one concerns interactions between bartonella quintana and endothelial cells by evaluation and modulation of apoptosis, signal transduction pathways and inflammation. the second one conc ... | 2000 | 11061635 |
| bactericidal effect of antibiotics on bartonella and brucella spp.: clinical implications. | the species bartonella and brucella are phylogenetically closely related bacteria, both of which can produce chronic infections in humans that are difficult to cure with antibiotics. mics of antibiotics for both species correlate poorly with the in vivo efficacy of the antibiotics. in this study we have determined mbcs of several antibiotics for this group of pathogens. only the aminoglycosides were bactericidal, and this correlates well with the usefulness of these antibiotics for the therapy o ... | 2000 | 11062204 |
| failure to detect bartonella henselae infection in synovial fluid from sufferers of chronic arthritis. | bartonella henselae causes granulomatous and indolent infection in the immune competent human, and angioproliferation in the context of persistent infection and impaired immunity. this bacterium is found in up to 40% of household cats, from which humans acquire it by either a cat scratch or a bite (hence the name, cat-scratch disease). approximately 5% of australian and us blood donors have serological evidence of past infection, but most associated illnesses are mild or subclinical. a number of ... | 2000 | 11063291 |
| bartonella henselae infection in british columbia: evidence for an endemic disease among humans. | human bartonellosis in north america is mainly associated with bartonella henselae, and the availability of laboratory diagnostic tools has significantly heightened awareness of the spectrum of human disease that is caused by this bacterium. we detail herein examples of illness in a pediatric population which serve to confirm that b. henselae-associated disease exists in british columbia. seroprevalence studies among asymptomatic adults and among children with symptomatic respiratory illness of ... | 2000 | 11068677 |
| disciforme keratitis caused by bartonella henselae: an unusual ocular complication in cat scratch disease. | cat scratch disease (csd) is a common infectious disease, however, its association with disciforme keratitis is a previously unreported ocular complication. with the use of the 16s rdna-pcr technique with subsequent dann sequencing on corneal material obtained by corneal scrape we were able to identify bartonella henselae in an unusual form of disciforme keratitis. | 2000 | 11071035 |
| [bacillary angiomatosis of the liver, a suspected ultrasound diagnosis?]. | infections with bartonella henselae or bartonella quintana present with vasoproliferative lesions in skin and parenchymatous organs in immunocompromised patients. a case report of a 38-year-old patient with hiv infection and hepatitis b surface antigen status is described. the dominant clinical symptoms in our patient were fever and icterus. ultrasonography of the abdomen showed a picture similar to that of liver cirrhosis. irregular (echorich) nodes with hyper-vascularization were suspected to ... | 2000 | 11072674 |
| bartonella henselae and inflammatory bowel disease. | sustained fever and increased thickness of the distal ileum on ultrasound suggested crohn's disease in an adolescent boy. bartonella henselae infection was diagnosed by specific serology and the patient recovered. ileitis could be related to b. henselae infection. | 2000 | 11072951 |
| images in clinical medicine. bartonella neuroretinitis. | | 2000 | 11078771 |
| hemin-binding surface protein from bartonella quintana. | bartonella quintana, the agent of trench fever and a cause of endocarditis and bacillary angiomatosis in humans, has the highest reported in vitro hemin requirement for any bacterium. we determined that eight membrane-associated proteins from b. quintana bind hemin and that a approximately 25-kda protein (hbpa) was the dominant hemin-binding protein. like many outer membrane proteins, hbpa partitions to the detergent phase of a triton x-114 extract of the cell and is heat modifiable, displaying ... | 2000 | 11083791 |
| [neck abscess as primary manifestation of head and neck carcinoma: implications for diagnostic management]. | neck abscesses and deep neck infections are common diseases in the field of otorhinolaryngology. however, malignant lymph node metastases presenting as abscesses are uncommon and have rarely been described up to now. | 2000 | 11089210 |
| recent advances in diagnosis and treatment of cat scratch disease. | the cause of cat scratch disease (csd), first described in france in 1950 and in the united states in 1951, was unknown until 1983 when the bacterium in lymph nodes was detected using a warthin-starry silver stain. afipia felis has been an infrequent cause of csd since1988, when this gram-negative bacterium was first isolated from 10 patients with csd. in 1992 bartonella organisms were isolated from immunocompetent and immunocompromised patients. an indirect fluorescent antibody test to detect b ... | 2000 | 11095849 |
| detection of serum antibodies to bartonella henselae and coxiella burnetii from japanese children and pregnant women. | the participation of bartonella henselae and coxiella burnetii in the pathogenesis of fever of unknown origin (fuo) and lymphadenopathy has not been completely clarified. prevalence of these two agents in japanese children is also unknown. serum igg and igm antibodies to b. henselae and to c. burnetii were examined by the indirect fluorescence antibody assay. enzyme immunoassay kits were used to detect serum igg and iga antibodies against chlamydia trachomatis. out of 200 healthy normal pregnant ... | 2000 | 11099929 |
| baccilary angiomatosis: negative results using normal balb/c and balb/c nude mice. | baccilary angiomatosis has recently been described as a disease that can spread systematically and that is potentially fatal. it is caused by bartonella henselae and b. quintana, and presents as especially pronounced signs and symptoms in patients suffering from acquired immunodeficiency syndrome (aids). to clarify the pathogenesis of the disease and to try to define the relationships among baccilary angiomatosis, cat scratch disease and carrión's bartonellosis, the authors of this study have at ... | 1998 | 11103022 |
| bartonella infection associated with systemic juvenile rheumatoid arthritis. | a 4-year-old girl with systemic juvenile rheumatoid arthritis had bartonella infection diagnosed serologically. this case suggested that bartonella (most probably bartonella henselae) infection may in part be responsible for the development of systemic juvenile rheumatoid arthritis. | 2001 | 11112671 |
| osteomyelitis of the hip joint associated with systemic cat-scratch disease in an adult. | reported here is the case of a 29-year-old male with cervical lymphadenopathy, fever and weight loss, followed by acute painful osteomyelitis of the left hip joint due to cat-scratch disease. the diagnosis was established by detection of igg antibodies to bartonella henselae in serum and histologic examination of a lymph node including a positive polymerase chain reaction test. treatment consisted of clarithromycin and cefotiam for 2 weeks. four weeks after discharge, all of the patient's sympto ... | 2000 | 11117643 |
| infection of fetal feline brain cells in culture with bartonella henselae. | bartonella henselae is known to cause central nervous system (cns) disease in humans, and neurological signs have been observed in experimentally infected cats. however, the pathogenesis of cns disease remains unclear. this study was undertaken to determine whether b. henselae infects feline fetal brain cells in vitro. microglial-cell- and astrocyte-enriched cultures were inoculated with b. henselae. giménez staining identified bacterial organisms within microglial cells by day 7 postinoculation ... | 2001 | 11119554 |
| evidence of bartonella henselae infection in cats and dogs in the united kingdom. | sera from cats and dogs in the uk were tested by elisa for antibodies to bartonella henselae. seropositivity was confirmed in 28 of 69 pet cats (40.6 per cent), 33 of 79 feral cats (41.8 per cent) and three of 100 pet dogs. reactivity to specific b. henselae antigens was confirmed by western blotting and demonstrated that consistent antigenic bands were bound by sera from the cats and dogs. | 2000 | 11132671 |
| neuroretinitis: a clinical syndrome of cat-scratch disease. | cat-scratch disease is usually a benign self-limited illness, characterized by regional lymphadenopathy lasting between 3 and 6 weeks. the causative organism is bartonella henselae, a small gram-negative rod. between 1 and 2% of patients who contract the illness experience blurred vision, metamorphopsia and scotomas as a result of neuroretinitis, an associated clinical syndrome. the classical clinical findings in cat-scratch neuroretinitis include disc edema and a stellate pattern of exudates in ... | 2000 | 11137430 |
| diagnosis and treatment of bartonella henselae infections. | | 2000 | 11144381 |
| bacillary angiomatosis in hiv-infected patients--an epidemiological and clinical study. | no data were available on the epidemiological and clinical characteristics of bacillary angiomatosis (ba) in germany. | 2000 | 11146343 |
| [disciform keratatis caused by bartonella henselae infection: detection of a rare ocular complication of cat-scratch disease with pcr]. | cat scratch disease (csd) is a common infectious disease, however its association with a disciforme keratitis is to our knowledge a previously unreported ocular complication. | 2000 | 11146830 |
| endocarditis due to rare and fastidious bacteria. | the etiologic diagnosis of infective endocarditis is easily made in the presence of continuous bacteremia with gram-positive cocci. however, the blood culture may contain a bacterium rarely associated with endocarditis, such as lactobacillus spp., klebsiella spp., or nontoxigenic corynebacterium, salmonella, gemella, campylobacter, aeromonas, yersinia, nocardia, pasteurella, listeria, or erysipelothrix spp., that requires further investigation to establish the relationship with endocarditis, or ... | 2001 | 11148009 |
| bartonella birtlesii sp. nov., isolated from small mammals (apodemus spp.). | three strains isolated from apodemus spp. were similar to bartonella species on the basis of phenotypic characteristics. futhermore, genotypic analysis based on sequence analysis of the 16s rrna and glta genes and on dna-dna hybridization showed that the three isolates represented a distinct and new species of bartonella. the name bartonella birtlesii is proposed for the new species. the type strain of b. birtlesii sp. nov. is ibs 325t (= cip 106294t = ccug 44360t). | 2000 | 11155970 |
| use of rpob gene analysis for detection and identification of bartonella species. | identification of bartonella species is of increasing importance as the number of infections in which these bacteria are involved increases. to date, these gram-negative bacilli have been identified by various serological, biochemical, and genotypic methods. however, the development of alternative tools is required, principally to circumvent a major risk of contamination during sample manipulation. the aim of our study was to investigate the possible identification of various bartonella species ... | 2001 | 11158086 |
| genetic variability and prevalence of bartonella henselae in cats in berlin, germany, and analysis of its genetic relatedness to a strain from berlin that is pathogenic for humans. | nineteen bartonella henselae strains and one bartonella clarridgeiae strain were isolated from blood samples of 97 pet cats and 96 stray cats from berlin, germany, indicating prevalence rates of 1 and 18.7%, respectively, for b. henselae and 0 and 1%, respectively, for b. clarridgeiae. eighteen of 19 b. henselae isolates corresponded to 16s rrna type ii. pulsed-field gel electrophoresis (pfge) analysis revealed seven different pfge types among the feline b. henselae strains. interestingly, all f ... | 2001 | 11158141 |
| high seroprevalence to bartonella quintana in homeless patients with cutaneous parasitic infestations in downtown paris. | bartonella quintana infections have recently been reported in homeless patients. we prospectively studied the prevalence of and the factors associated with a positive serology to b quintana in the homeless population of downtown paris. the following data were recorded: ongoing cutaneous parasitic infestation, years of homelessness, living status, previous episodes of body pediculosis and scabies, alcoholism, intravenous drug use, known immunodepression (including undernutrition and known hiv inf ... | 2001 | 11174378 |
| treatment of cat-scratch disease. | cat-scratch disease is an infection caused by bartonella henselae, a fastidious gram-negative bacillus acquired from exposure to an infected kitten or cat. the most common manifestation of human disease is lymphadenitis. atypical forms of infection include parinaud oculoglandular syndrome, stellate neuroretinitis, persistent fever without localizing signs, hepatosplenic infection, encephalopathy, osteomyelitis, and endocarditis. immunocompromised individuals with b. hensalae infection may develo ... | 2001 | 11176245 |
| experimental model of human body louse infection using green fluorescent protein-expressing bartonella quintana. | a laboratory colony of human body lice was experimentally infected by feeding on rabbits made artificially bacteremic with a green fluorescent protein-expressing bartonella quintana. b. quintana was detected in the gut and feces until death but not in the eggs. the life span of the lice was not modified. the rabbit model should provide valuable clues to the role of lice in the transmission of b. quintana. | 2001 | 11179366 |
| passive antibody to bartonella henselae protects against clinical disease following homologous challenge but does not prevent bacteremia in cats. | we challenged cats transfused with anti-bartonella serum and kittens born to antibody-positive queens with bartonella henselae to determine the contribution of antibodies to the control of b. henselae in cats. in both experiments, antibody-positive cats were protected from clinical disease but passive antibody to the homologous strain of b. henselae did not prevent bacteremia. | 2001 | 11179367 |
| association of bartonella species and coxiella burnetii infection with coronary artery disease. | coronary artery disease is an inflammatory condition associated with several infections. we prospectively evaluated 155 consecutive patients undergoing coronary angiography for evidence of bartonella species and coxiella burnetii infection. all bartonella cultures were found to be negative. multivariable logistic regression analysis that controlled for potential confounding factors revealed no association between coronary artery disease and seropositivity to bartonella henselae (odds ratio [or], ... | 2001 | 11181164 |
| cat-scratch disease. | cat-scratch disease (csd) was first described by debré in 1950, yet the causative bacterial agent of csd remained obscure until 1992, when bartonella (formerly rochalimaea) henselae was implicated in csd by serological and microbiologic studies. bartonella henselae had initially been linked to bacillary angiomatosis (ba), a vascular proliferative disease most commonly associated with long-standing human immunodeficiency virus infection or other significant immunosuppression. bartonella henselae ... | 2000 | 11189710 |
| determination of the rpob gene sequences of bartonella henselae and bartonella quintana for phylogenic analysis. | using the genome walker procedure, which allows pcr amplification of genomic dna using a single gene-specific primer and direct automated sequencing methodology, we obtained the nucleotide sequence of the rna polymerase beta subunit (rpob) from bartonella henselae and bartonella quintana. a phylogenetic tree constructed from these data and other rpob sequences available in genbank is, in part, consistent with those previously derived from 16s rrna gene sequences and confirms the position of bart ... | 2000 | 11191808 |
| three cases of cat scratch disease diagnosed by indirect immunofluorescence antibody assay and/or polymerase chain reaction of 16s rrna gene of bartonella henselae. | three suspected cases of cat scratch disease were diagnosed by indirect immunofluorescence antibody assay and/or polymerase chain reaction. patient 1 was a 10-year-old female who presented swelling of the right axillary [corrected] lymph nodes with pain and fever. she kept a kitten, and many scratches were observed on her both legs and dorsum manus. antibody titers against bartonella (b.) henselae were 1:32 for igm 3 weeks after the onset of the symptoms and 1:64 for igg 8 weeks after the onset. ... | 2000 | 11193351 |
| factors affecting the component community structure of haemoparasites in bank voles (clethrionomys glareolus) from the mazury lake district region of poland. | the prevalence and abundance of infections with haemoparasites were studied over a 3 year period in clethrionomys glareolus (bank vole, n = 420) sampled from forests in the ne of poland. total species richness was 5 (prevalence = haemobartonella sp. 63.1%, bartonella grahamii 27.4%, hepatozoon erhardovae 31.4%, trypanosoma evotomys 15% and babesia microti 1.0%) with 81.9% of the voles carrying at least 1 species and a mean infracommunity species richness of 1.4. variation in species richness was ... | 2001 | 11197763 |
| cervical lymphadenitis and cat scratch disease (csd): an overlooked disease? | cat scratch disease (csd) is a benign disease characterized by regional lymphadenopathy affecting most frequently the head and neck region in children and young adults. in the present paper, the authors describe four cases of csd focusing on clinical history, diagnostic management and therapy. the main germ responsible for this lymph node disease is bartonella henselae. diagnosis is based on history, serology and histological findings. clinical evolution is generally favorable despite the fact t ... | 2000 | 11205454 |
| detection of bartonella henselae and afipia felis dna by polymerase chain reaction in specimens from patients with cat scratch disease. | polymerase chain reaction (pcr) amplification and colorimetric identification of amplicons were performed to detect bartonella henselae and afipia felis dna in specimens from patients who were clinically and histologically suspected of having cat scratch disease. pcr products were revealed using 2% ethidium bromide agarose-gel electrophoresis and identified with specific probes in a commercial colorimetric hybridization assay (deia) (gen-eti-k; diasorin, italy). six paraffin-embedded lymph node ... | 2000 | 11205638 |