| emerging incidence of lyme borreliosis, babesiosis, bartonellosis, and granulocytic ehrlichiosis in australia. | borrelia burgdorferi, the causative agent of lyme disease (ld), and babesia, bartonella, and ehrlichia species (spp.) are recognized tick-borne pathogens in humans worldwide. using serology and molecular testing, the incidence of these pathogens was investigated in symptomatic patients from australia. | 2011 | 22267937 |
| persistence of bartonella spp. stealth pathogens: from sub-clinical infections to vasoproliferative tumour formation. | bartonella spp. are facultative intracellular bacteria that typically cause a long-lasting intraerythrocytic bacteremia in their mammalian reservoir hosts, thereby favoring transmission by blood-sucking arthropods. in most cases, natural reservoir host infections are subclinical and the relapsing intraerythrocytic bacteremia may last weeks, months or even years. in this review, we will follow the infection cycle of bartonella spp. in a reservoir host, which typically starts with an intradermal i ... | 2012 | 22229763 |
| adenylylation control by intra- or intermolecular active-site obstruction in fic proteins. | fic proteins that are defined by the ubiquitous fic (filamentation induced by cyclic amp) domain are known to catalyse adenylylation (also called ampylation); that is, the transfer of amp onto a target protein. in mammalian cells, adenylylation of small gtpases through fic proteins injected by pathogenic bacteria can cause collapse of the actin cytoskeleton and cell death. it is unknown how this potentially deleterious adenylylation activity is regulated in the widespread fic proteins that are f ... | 2012 | 22266942 |
| q fever endocarditis in romania: the first cases confirmed by direct sequencing. | infective endocarditis (ie) is a serious, life-threatening disease with highly variable clinical signs, making its diagnostic a real challenge. a diagnosis is readily made if blood cultures are positive, but in 2.5 to 31% of all infective endocarditis cases, routine blood cultures are negative. in such situations, alternative diagnostic approaches are necessary. coxiella burnetii and bartonella spp. are the etiological agents of blood culture-negative endocarditis (bcne) most frequently identifi ... | 2011 | 22272146 |
| granulomatous hepatitis due to bartonella henselae infection in an immunocompetent patient. | abstract: background: bartonella henselae (b. henselae) is considered a rare cause of granulomatous hepatitis. due to the fastidious growth characteristics of the bacteria, the limited sensitivity of histopathological stains, and the non-specific histological findings on liver biopsy, the diagnosis of hepatic bartonellosis can be difficult to establish. furthermore, the optimal treatment of established hepatic bartonellosis remains controversial. case presentation: we present a case of hepatic ... | 2012 | 22269175 |
| molecular detection of bartonella species in ticks from peru. | a total of 103 ticks, collected from canines, horses, donkeys, and snakes from peru, were screened for the presence of bartonella dna by polymerase chain reaction analysis. bartonella dna was detected in two ticks using bartonella 16s-23s intergenic spacer region primers and in an additional two ticks using bartonella nadh dehydrogenase gamma subunit gene (nuog) primers. bartonella rochalimae eremeeva et al., b. quintana schmincke, and b. elizabethae daly et al. dna was detected in a rhipicephal ... | 2011 | 22238888 |
| hemin binding protein c is found in outer membrane vesicles and protects bartonella henselae against toxic concentrations of hemin. | bartonella species are gram-negative, emerging bacterial pathogens found in two distinct environments. in the gut of the obligately hematophagous arthropod vector, bartonellae are exposed to concentrations of heme that are toxic to other bacteria. in the bloodstream of the mammalian host, access to heme and iron are severely restricted. bartonellae have unusually high requirements for heme, which is their only utilizable source of iron. although heme is essential for bartonella survival, little ... | 2012 | 22232189 |
| a new rickettsia species found in fleas collected from human dwellings and from domestic cats and dogs in senegal. | abstract the insects of the order siphonaptera, commonly named fleas, are vectors of pathogens around the world. our previous studies showed that 4.4% of acute febrile diseases in the sine-saloum region of senegal were due to rickettsia felis. the aim of this study was to explain the high prevalence of r. felis infections in two rural senegalese populations by an entomological, systematic monitoring protocol. a total of 232 fleas from three species (ctenocephalides felis, echidnophaga gallinac ... | 2012 | 22214272 |
| intruders below the radar: molecular pathogenesis of bartonella spp. | summary: bartonella spp. are facultative intracellular pathogens that employ a unique stealth infection strategy comprising immune evasion and modulation, intimate interaction with nucleated cells, and intraerythrocytic persistence. infections with bartonella are ubiquitous among mammals, and many species can infect humans either as their natural host or incidentally as zoonotic pathogens. upon inoculation into a naive host, the bartonellae first colonize a primary niche that is widely accepted ... | 2012 | 22232371 |
| identification of a new nanornase in bartonella. | in escherichia coli, only one essential oligoribonuclease (orn) can degrade oligoribonucleotides of five residues and shorter in length (nanorna). in bacillus subtilis, nrna and nrnb, which do not have any sequence similarity with orn, have been identified as functional analogs of orn. sequence comparisons did not allow identifying orn, nrna, or nrnb homologues in the genomes of the chlamydia/cyanobacteria and alphaproteobacteria family members. screening a genomic library from bartonella birtle ... | 2012 | 22262096 |
| bartonella quintana transmission from mite to family with high socioeconomic status. | to the editor: urban trench fever caused by bartonella quintana has been reported in persons who abuse alcohol and in homeless persons in large cities worldwide. symptoms vary from asymptomatic intermittent bacteremia to serious complications (1). pediculus humanus lice, the known vector of the infection, are not always identified, which raises the possibility that other vectors might also be involved (2). we report on an outbreak of b. quintana infection among a young family of high socioeconom ... | 2012 | 22257438 |