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culture negative endocarditis caused by bartonella henselae in a child with congenital heart disease.a 9-year-old white male with congenital aortic and subaortic stenosis palliated by the ross-konno procedure presented with culture-negative endocarditis. serologic studies and polymerase chain reaction testing of resected homograft valvular tissue provided evidence of bartonella henselae as the etiology. b. henselae can cause endocarditis in children, particularly those with underlying valvular disease. serologic testing for b. henselae should be considered in children with culture-negative endo ...200919738506
comparative in vivo adulticidal activity of a topical dinotefuran versus an imidacloprid-based formulation against cat fleas (ctenocephalides felis) on cats.fleas cause significant discomfort to pet cats and distress to their owners and are also vectors of disease severe infestations can cause anemia or flea allergy dermatitis and can lead to infections with dipylidium caninum and bartonella henselae. rapid flea kill is an important feature of flea preventives. the efficacy of dinotefuran (vectra for cats and kittens, summit vetpharm) was compared with that of imidacloprid (advantage, bayer animal health) against ctenocephalides felis when applied t ...200919742443
rapid detection of bartonella henselae heat shock protein dna by nested polymerase chain reaction from swollen lymph nodes of a patient with cat-scratch disease. 200919785710
cat scratch disease--heterogeneous in clinical presentation: five unusual cases of an infection caused by bartonella henselae.cat-scratch disease (csd) is common in children, however the wide spectrum of the clinical presentation of csd may lead to delayed diagnosis. an atypical presentation of csd includes in its differential diagnosis diseases such as tuberculosis, other mycobacterioses, epstein-barr-virus infection (ebv) or malignant disease. since, in a small number of cases, these diseases may be present concurrently with an active csd, it is important to consider csd early in the differential diagnosis and order ...201019790029
detection of bartonella henselae--dna in macronodular hepatic lesions of an immunocompetent woman. 200919793123
prevalence of coxiella burnetii and bartonella species as cases of infective endocarditis in marseilles (1994-2007). 200919793124
comparison of the performances of mlva vs. the main other typing techniques for bartonella henselae. 200919793125
molecular detection of bartonella quintana in human body lice from mexico city. 200919793127
susceptibility of owl monkeys (aotus nancymaae) to experimental infection with bartonella bacilliformis.bartonellosis, caused by bartonella bacilliformis, is a clinically significant disease in parts of south america, where it is characterized by fever and hemolytic anemia during the often-fatal acute stage and warty skin eruptions during chronic disease. in this study, we evaluated owl monkeys (aotus nancymaae) as a potential model for studying the immunogenicity and pathology of bartonellosis. two groups of animals (n = 3 per group) received either 9.5 x 10(7) cfu b. bacilliformis by the id rout ...200819793460
[investigation of bartonella henselae seroprevalence and related risk factors in blood donors admitted to pamukkale university blood center].bartonella henselae is an emerging infectious agent that mainly causes cat scratch disease, basillary angiomatosis and peliosis hepatitis. although many basillary angiomatosis cases have been reported especially from the mediterranean region of turkey, adequate data about the seroprevalence of b. henselae in turkey does not exist. the aim of this study was to investigate the seroprevalence of b. henselae in volunteer blood donors and the related risk factors. in this study, sera samples were ran ...200919795614
[pcr rdna 16s used for the etiological diagnosis of blood culture negative endocarditis].we report the case of a 55 year-old man presenting with a double aortic and mitral endocarditis for which resected valve culture was repeatedly negative. specific pcr made on valves because of highly positive blood tests for bartonella henselae remained negative. a molecular approach was made with 16s rdna pcr, followed by sequencing. bartonella quintana was identified as the etiology of endocarditis. b. quintana, "fastidious" bacteria, even if hard to identify in a laboratory, is often reported ...201019796889
a serologically proven case of cat-scratch disease presenting with neuroretinitis.cat-scratch disease is a clinical syndrome that usually presents as a self-limiting illness featuring regional lymphadenopathy, fever, and small skin lesions in association with a cat scratch or bite. it is caused by the gram-negative bacillus bartonella henselae, which commonly affects children and young adults. ocular bartonellosis is the most common atypical manifestation of cat-scratch disease. it can present with a wide spectrum of ocular diseases including neuroretinitis, parinaud's oculog ...200919801700
[cat-scratch disease with bone compromise: atypical manifestation].fever, headache, myalgias and lymphadenopathy are characteristic manifestations of cat-scratch disease but other less common findings are described in 2 to 10% of cases. we report two children that presented with hepatosplenic abscesses and bone involvement. one child, had multiple areas of increased uptake in the bone scintigram with a positive serology (igg > 1/256, igm slightly positive). the second child had destruction of the l2 vertebral body that compromised the channel and right foramen ...200919802407
blood transfusion as an alternative bartonellosis transmission in a pediatric liver transplant. 200919804481
[fever and abdominal pain in a 56-year-old woman]. 200919815317
receptor recognition of and immune intracellular pathways for veillonella parvula lipopolysaccharide.veillonella parvula is an anaerobic gram-negative coccus that is part of the normal flora of the animal and human mouth and gastrointestinal and genitourinary tracts. oral v. parvula is involved in the development of early periodontal disease as well as different types of serious infections. present data on molecular mechanisms responsible for innate immune response against veillonella are very scanty. the aim of this study was to investigate the toll-like receptor (tlr) pathways responsible for ...200919828771
fatal myocarditis-associated bartonella quintana endocarditis: a case report.bartonella spp. infection is not rare and must be considered with great care in patients with suspected infective endocarditis, particularly if regular blood cultures remain sterile. management of these infections requires knowledge of the identification and treatment of these bacteria.200919830188
babesia canis and other tick-borne infections in dogs in central poland.vector-borne infections constitute increasing health problem in dogs worldwide, including sled dogs, dramatically decreasing the fitness of working dogs and even leading to death. in the period 2006-2008 eighty-two blood samples were collected from eight sled dog kennels in central poland. the prevalence of four vector-borne infections (babesia canis, bartonella sp., anaplasma/ehrlichia and borrelia burgdorferi) was estimated in 82 sled dogs using pcr and nested pcr for diagnosis and the same me ...200919837515
[oral cavity health condition of hiv carriers].acquired immune deficiency syndrome (aids) is a disease, which damages the cell immunity of an organism. changes in the oral cavity have an important role in the diagnostics of contagion. the aim of the paper was the assessment of the state of the oral cavity of the patients who had hiv. they had also antiretroviral and immunomodulating treatment.200819839516
seroprevalence of bartonella henselae in patients with uveitis and healthy individuals in tokyo.to compare the seroprevalence of bartonella henselae, a pathogen of cat scratch disease, in patients with uveitis and in healthy individuals.200919847604
prevalence and genetic heterogeneity of bartonella strains cultured from rodents from 17 provinces in thailand.to study the distribution and diversity of bartonella in rodents from thailand, 330 rodents belonging to 13 species were tested. the majority (80.6%) of rodents examined belonged to the genus rattus. bartonellae were cultured from 41.5% of the rodents with a wide range of prevalence by host species and regions. sequencing of glta revealed diverse bartonella strains. bartonellae from rattus spp. belonged to 23 variants and clustered with bartonella coopersplainensis, bartonella elizabethae, barto ...200919861616
etiology of oroya fever : i. cultivation of bartonella bacilliformis.a pure culture of a microorganism resembling in morphology and pathogenic action bartonella bacilliformis has been obtained from blood taken during life from a case of oroya fever which ended fatally. the blood taken at lima into citrate solution and transported to new york at refrigerator temperature yielded positive cultures 28 days after its withdrawal from the patient. the strain of bartonella bacilliformis thus isolated grows well on the semisolid leptospira medium, and also on slant agar c ...192619869166
etiology of oroya fever : ii. viability of bartonella bacilliformis in cultures and in the preserved blood and an excised nodule of macacus rhesus.1. animals immunized with the formalinized filtrates of young toxic cultures of b. botulinus produce an antitoxic serum poor in precipitins. 2. animals immunized with the formalinized filtrates of old and partly autolyzed toxic cultures produce an antitoxic serum containing precipitins. 3. animals immunized with toxin-free autolyzed bacteria produce a serum free from antitoxin but rich in specific precipitins. 4. animals immunized with the filtrates of an atoxic variant produce a serum free from ...192619869204
etiology of oroya fever : iii. the behavior of bartonella bacilliformis in macacus rhesus.the experiments reported here were carried on in the main with passage strains of bartonella bacilliformis, and the results indicate that the virulence of the organism has been considerably enhanced by passage through susceptible animals. while the animals of the earlier experimental series showed no anemia, some of the present group manifested a definite reduction in the number of red cells and in hemoglobin, and in one instance (m. rhesus 25) anemia was of the extreme type so often associated ...192619869217
etiology of oroya fever : iv. the effect of inoculation of anthropoid apes with bartonella bacilliformis.the inoculation of a chimpanzee with cultures and a passage strain of bartonella bacilliformis induced local reactions which, while definite and characteristic, progressed less rapidly and were much less striking than those in the control rhesus monkey. bartonella bacilliformis was demonstrated in the blood corpuscles with difficulty, and the fever was slight compared with the high and persistent fever of the rhesus monkey. in both the swelling of the lymph glands was an early symptom and consta ...192619869218
etiology of oroya fever : v. the experimental transmission of bartonella bacilliformis by ticks (dermacentor andersoni).experiments are reported in which bartonella bacilliformis was transmitted from infected to normal rhesus monkeys by the bite of the tick, dermacentor andersoni. a long period of feeding, both on the infected animal and on the normal animal subjected to infection, was required in order to secure positive results. the infection transmitted by the ticks was mild, but definite, as shown by the recovery of bartonella bacilliformis from the lymph nodes and blood.192619869219
the etiology of verruga peruana.a saline suspension of a subcutaneous nodule excised from a verruga patient, and kept in the refrigerator for 14 days, on inoculation into two young macacus rhesus monkeys (nos. 33 and 34) induced irregular febrile reactions and enlargement of the lymph glands, and in one instance a subcutaneous nodule arose, independently of direct inoculation, on the tail. a microorganism has been isolated from the blood of both animals, and from the experimental nodule, which in pathogenic properties and in c ...192719869238
etiology of oroya fever : vi. pathological changes observed in animals experimentally infected with bartonella bacilliformis. the distribution of the parasites in the tissues.the pathological changes observed in the organs in macacus rhesus monkeys which have succumbed to severe infection with bartonella bacilliformis are similar to those found in human organs in persons dying of oroya fever. the characteristic changes in the liver are the zonal necrosis of the cells around the hepatic veins, involving active macrophagocytosis of invading polymorphonuclear leucocytes in the necrotic areas, and a marked endothelial hyperplasia in the sinusoids or around the portal vei ...192719869264
etiology of oroya fever : vii. the response of the skin of macacus rhesus and anthropoid apes to inoculation with bartonella bacilliformis.bartonella bacilliformis failed to induce lesions when merely rubbed on the surface of the intact skin of a chimpanzee, an ourang-utan, and numerous macacus rhesus monkeys, although when applied to the scarified skin of the same animals it gave rise to extensive lesions. application of infectious material to the scarified skin did not always induce verruga lesions, but intradermal inoculation almost invariably gave rise to nodule formation. the localization of bartonella bacilliformis in the ski ...192719869265
etiology of oroya fever : viii. experiments on cross-immunity between oroya fever and verruga peruana.nine monkeys (macacus rhesus) and a chimpanzee which had recently recovered from an infection with the oroya strain of bartonella bacilliformis were tested for immunity against the verruga strain of bartonella bacilliformis as well as against the homologous strain. complete immunity to both strains was demonstrated. the result establishes the identity of the strains and is in agreement with the result of comparative serological study. the criteria of recovery include not only the subsidence of f ...192719869288
etiology of oroya fever : ix. bacterium peruvianum, n. sp., a secondary invader of the lesions of verruga peruana.a minute, pleomorphic, motile, gram-negative bacterium has been isolated from two specimens of nodular tissue from human verruga. in films and sections of the original tissues the organism in question is difficult to distinguish from bartonella bacilliformis, with which it was associated, and even in pure culture it has a number of properties in common with that parasite. no sugars are fermented by it, it is an obligate aerobe, the optimum temperature for its growth is 25 degrees c., and it has ...192819869395
etiology of oroya fever : x. comparative studies of different strains of bartonella bacilliformis, with special reference to the relationship between the clinical types of carrion's disease and the virulence of the infecting organism.through the cooperation of dr. sebastian lorente, director of the national department of public health of peru, nine strains of bartonella bacilliformis have been isolated, by means of the semisolid leptospira medium, from nine of twelve specimens of blood withdrawn from cases of verruga and forwarded from peru under conditions of refrigeration. the cultural titer of the blood specimens immediately after their arrival (2 weeks after withdrawal) varied from 1:10 to 1:100,000. blood from the sever ...192819869408
etiology of oroya fever : xi. comparison of bartonella bacilliformis and bartonella muris. cultivation of bacterium murium, n. sp.bartonella muris appeared in the blood of all white rats, wild rats, chinese hamster, and mice, from which the spleen was removed, but did not appear in that of splenectomized monkeys, rabbits, or guinea pigs. it has not been possible to transmit b. muris to normal rats, monkeys, rabbits, or guinea pigs, by intraperitoneal, intradermal, or intravenous injection of blood containing b. muris from splenectomized rats. in two instances an acute orchitis was induced in normal rats by injection direct ...192819869409
etiology of oroya fever : xii. influence of malarial infection (plasmodium inui?), splenectomy, or both, upon experimental carrion's disease in monkeys.the experiments reported were designed to determine the influence of malarial infection (plasmodium inui?), splenectomy, or both combined, upon the course and character of experimental infection with bartonella bacilliformis in monkeys (macacus rhesus and m. cynomolgus). blood withdrawn from a monkey showing spontaneous malarial infection was inoculated intravenously into monkeys (a) 1 month prior to inoculation with virulent verruga material, (b) simultaneously with the verruga material, and (c ...192819869445
the transfer of rat anemia to normal animals.fifty-eight white and hooded rats have been splenectomized and all of them have shown a more or less severe anemia and an infection of the red blood cells with bartonella muris. another strain of white rats obtained from littlestown showed no anemia and no bartonellas in the blood after splenectomy, until exposed to infected rats. others of these littlestown rats, kept in the laboratory for some time before operation and exposed to infected rats, came down with bartonella anemia within 6 days af ...192819869499
etiology of oroya fever : xiii. chemotherapy in experimental bartonella bacilliformis infection.the therapeutic effect of several antiparasitic chemicals on experimental verruga peruana is described. the drugs were administered by intravenous injection according as the nodules (1) were already developed to an approximate maximum, or (2) were still in the active period of growth. the effect of the drugs was different under the two circumstances of their administration. when they were given after the maturity of the nodules they hastened the regressive process, but when given during active g ...192819869508
etiology of oroya fever : xiv. the insect vectors of carrion's disease.with a view to determining the mode of infection in carrion's disease, a study of the blood-sucking insects found in the districts of peru where the disease prevails has been carried out, through the cooperation of the rockefeller institute and the rockefeller foundation. the material studied included ticks, mites, midges, lice, fleas, bedbugs, mosquitoes, buffalo gnats, horse-flies, "sheep ticks," 3 species of streblidae, and 3 species of phlebotomus, including phlebotomus verrucarum townsend a ...192919869598
etiology of oroya fever : xv. effect of immune serum on the course of bartonella bacilliformis infection in macacus rhesus.experiments are reported on the effect upon the course of experimental verruga peruana in macacus rhesus of the injection of (1) small quantities of rabbit immune serum simultaneously with living cultures, (2) one large dose of convalescent monkey serum 24 hours prior to inoculation, (3) a similar preliminary dose followed by three subsequent injections of the serum, (4) three large doses of convalescent serum, following the inoculation. the convalescent serum was found (1) to prevent the multip ...192919869628
etiology of oroya fever : xvi. verruga in the dog and the donkey.in the experiments here reported, definite verruga lesions, in which the presence of bartonella bacilliformis was established by culture or by passage to rhesus monkeys, were produced in a dog and in a donkey by inoculation of cultures or monkey passage strains. the reaction induced in these animals was entirely local, however; blood cultures were sterile. histologically, the lesions produced were similar to those obtained in monkeys by inoculation of bartonella bacilliformis, except for the pre ...192919869639
the effect of the x-ray on the nodules of verruga peruana.the supposition that x-ray would affect the developing and the developed verruga nodules experimentally induced in the monkey, has proved correct. the experiments show that the early verruga nodules when exposed to a single, properly graduated dose of x-ray producing merely erythema of the skin, are inhibited in their evolution. moreover, the skin of macacus rhesus monkeys is modified by a single erythema dose of x-ray in such a way that infection of it with bartonella bacilliformis is rendered ...193019869674
studies on bartonella muris anemia of albino rats : i. trypanosoma lewisi infection in normal albino rats associated with bartonella muris anemia ii. latent infection in adult normal rats.1. the virus of bartonella muris anemia of splenectomized rats may be transmitted to normal young unoperated rats and rabbits. this confirms the observations of ford and eliot. 2. trypanosoma lewisi infections in normal adult rats are accompanied by an anemia most marked at the height of the infection and the appearance of bartonella muris bodies in the red blood cells. 3. in young rats trypanosoma lewisi may produce death from the severity of the anemia, complicating the disease. the anemic vir ...193019869745
studies on bartonella muris anemia of albino rats : iii. the protective effect of autoplastic splenic transplants on the bartonella muris anemia of splenectomized rats.autoplastic splenic transplants were made in adult albino rats 4 weeks and 7 weeks prior to splenectomy and the protective effects against infection with the bartonella muris anemia observed. 1. one-fourth of the spleen left in situ will protect adult albino rats against the bartonella muris anemia. 2. autotransplantation of splenic tissue in adult rats is successful in over 90 per cent of instances. 3. autoplastic splenic transplants performed 7 weeks prior to splenectomy afford protection agai ...193019869746
further studies on t. lewisi infection in albino rats : i. the effect of splenectomy on t. lewisi infection in albino rats and the protective action of splenic autotransplants ii. the effect of thymectomy and bilateral gonadectomy on t. lewisi infection in albino rats.t. lewisi infection in normal adult 3 month old albino rats raised from a single stock and maintained under identical conditions was studied. daily quantitative estimates of the trypanosomes in the circulating blood were made and the course of the infection was studied. bilateral suprarenalectomy in rats lowers the resistance to a subsequent infection with t. lewisi. about 70 per cent of these rats die in an average period of 5.8 days after injection. the multiplication of the parasites, in the ...193019869791
compensatory hypertrophy of the spleen.following the removal of half of the spleen in young adult rats there is a compensatory enlargement of the remaining portion of about 50 per cent while in mature rabbits no such compensatory hypertrophy follows a similar procedure. it is uncertain whether this difference is due to a difference in the function of the spleen in the two species or to the fact that the rats were infected with bartonella muris while the rabbits were not.193119869845
studies on bartonella muris anemia : iv. pathological changes during the acute anemia.the pathological changes that follow a severe infection with bartonella muris in the adult or young albino rat are: first, those that result from the release of large quantities of cellular debris in the circulating blood. there is phagocytic activity and hyperplasia of the endothelial elements of the liver, thymus, lymph nodes and, in the young rat, of these elements in the spleen, with resultant capillary thromboses and focal necroses. second, changes result from the anemia as such-fatty metam ...193119869889
studies on bartonella muris anemia : v. compensatory phenomena following splenectomy in the adult albino rat.in bartonella muris carrier stock certain changes are observed in the lymphoblastic and reticular and endothelial elements after splenectomy and recovery from the anemia. these changes appear 3 to 5 months after splenectomy and are associated with immunity to further infection with bartonella muris. the changes consist primarily of hyperplasia of hemolymph tissue, hyperplasia of reticular and endothelial elements of lymph nodes, the formation of lymphoblastic foci periportally in the liver and p ...193119869890
the effect of bilateral suprarenalectomy in adult albino rats on the natural and acquired resistance to bartonella muris anemia.normal adult wistar rats (non-carrier stock) are readily infected with bartonella muris and develop a severe anemia if large amounts of infecting material are used. the normal adult rat of wistar stock possesses a relatively high natural resistance to spontaneous infection with this organism. bilateral suprarenalectomy in wistar rats lowers the natural resistance to a subsequent infection with bartonella muris. this procedure does not alter the type of tissue response to the virus but lowers the ...193219869970
the etiology of bartonella muris anemia of the albino rat : the isolation of bartonella muris.1. bartonella muris has been isolated in pure culture on noguchi's leptospira medium from the blood of the splenectomized adult rat suffering with bartonella muris anemia. 2. bartonella muris is a small, actively motile, gram-negative bacillus. it grows best on media containing blood and on noguchi's leptospira medium. the optimal temperature for growth is 20-25 degrees c. it produces neither gas nor acid on media containing sugars. it does not hemolyze blood in artificial media. viability of th ...193219870100
studies on bartonella muris anemia : vi. a lipoid extract of the spleen that prevents bartonella muris anemia in splenectomized albino rats.an aqueous lipoid extract of ox spleen was prepared which protects adult male albino rats of carrier stock in a large percentage of instances against bartonella muris anemia following splenectomy. it is suggested that the extract contains a specific hormonal substance.193219870101
studies on bartonella muris anemia : vii. the protective action of copper and iron against bartonella muris anemia.the effect on bartonella muris anemia of adding copper or iron or both to an adequate diet was studied. the addition to the diet of copper (0.1 mg. per rat per day), or iron (1 mg. per day), or both during a period of 2 days prior to splenectomy and 1 month subsequent thereto failed to protect adult albino rats against bartonella muris anemia. the addition of copper to an adequate diet for a period of 10 days prior to splenectomy and 1 month subsequent thereto protected 75 per cent of the rats a ...193219870102
studies on bartonella muris anemia : viii. changes in the chemical constituents of the blood during the anemia.1. the blood chemistry of normal adult rats and of splenectomized adult rats suffering with bartonella muris anemia has been studied. 2. non-protein nitrogen rises with the increase in severity of the anemia. total serum proteins, serum albumin and serum globulin decrease slightly. uric acid remains unchanged. 3. serum chloride concentration remains unchanged, but the concentration of chlorides in the blood increases. 4. an acidosis as estimated by the carbon dioxide-combining capacity of the bl ...193319870123
the metabolism of copper and iron in splenectomized rats free from bartonella muris infection.removal of the spleen in albino rats free from bartonella muris infection is followed by an increased elimination of copper in the feces, which commences 2 weeks after splenectomy. this is associated with a persistent negative copper balance. an increased retention of iron occurs during a period of 4 to 6 weeks after splenectomy with a return of the iron metabolism to normal after this period. no disturbance in creatine or creatinine metabolism occurs. the uric acid amount is unchanged. there is ...193419870310
i. bartonella incidence in splenectomized bile fistula dogs.splenectomized bile fistula dogs in this laboratory have regularly exhibited spontaneous periods of anemia, which are associated with excessive bile pigment production. in three out of four dogs, such periods have been shown to be associated with the presence in the blood of bodies morphologically indistinguishable from descriptions of bartonella canis. simple splenectomized dogs have not shown such periods of anemia arising spontaneously. inoculations of blood containing bartonella bodies into ...193519870340
ii. hemoglobin and bile pigment overproduction in the splenectomized bile fistula dog.blood destruction associated with bartonella or with a drug (hydrazine) in bile fistula dogs yields a large pigment excess. these dogs form large amounts of new hemoglobin and bile pigment on a diet which permits of but little new hemoglobin production in standard anemic dogs. when hemoglobin formation and hemoglobin destruction are occurring rapidly and simultaneously, estimations of the percentage of circulating hemoglobin alone, though showing the eventual total increase or decrease of this s ...193519870341
the association of bartonella bodies with induced anemia in the dog.on feeding to splenectomized dogs a diet producing black tongue, severe anemia developed associated with the presence of small bodies in or on the erythrocytes. the bodies were morphologically similar to bartonella muris and bartonella canis. the addition of lean beef to the diet, a material prophylactic against its effects, was followed by improvement of the blood levels, the presence of increased numbers of reticulocytes in the circulating blood, and the disappearance of the bodies. when the b ...193519870342
bartonella bodies in the blood of a non-splenectomized dog.a non-splenectomized dog, on a vitamin-adequate basal diet, in the course of a plasmapheresis experiment, developed an uncontrollable anemia associated with the presence of bodies in or on the erythrocytes, indistinguishable from the descriptions of bartonella canis. the normal plasma protein level of 7.3 per cent was reduced to 4.1 per cent by diet and the removal of 5354 ml. of whole blood in 33 bleedings. the bartonella infection was transferred to a splenectomized dog by an intravenous injec ...193519870420
relation of the hypophysis to the spleen : i. effect of hypophysectomy on growth and regeneration of spleen tissue ii. the presence of a spleen-stimulating factor in extracts of anterior hypophysis.1. removal of the hypophysis in adult rats is followed by progressive atrophy of the spleen. at the end of 2 months the ratio of spleen weight to body weight is one-half the normal. the administration of hypophyseal emulsion repairs to a considerable degree the atrophy of the spleen in such animals. 2. hypophysectomy completely inhibits the regeneration of splenic tissue after partial splenectomy. administration of anterior hypophyseal emulsion restores the regenerative capacity of splenic tissu ...193619870492
bile and blood plasma cholesterol as influenced by blood destruction in normal and bile fistula dogs.destruction of large amounts of red cells in normal and bile fistula dogs by means of acetyl phenylhydrazine causes no significant alterations of the blood plasma but there is some decrease in the bile cholesterol. during bartonella canis infection the splenectomized bile fistula dog periodically breaks down large quantities of red cells with slight decrease in the plasma cholesterol and marked decrease in the bile cholesterol. in the periods of blood regeneration following such acute anemias th ...193819870758
the reticulo-endothelial system and hormone refractoriness.1. young splenectomized female rats, free of latent infection, show greater increases in ovarian weight in response to injections of pregnant mare's serum than do young normal rats with spleens intact. 2. the regression in ovarian weight which occurs after about a month in such injected splenectomized animals may be prevented by repeated injections of an agent like trypan blue which causes blockage of the compensating reticulo-endothelial elements. 3. the plasmas obtained from these splenectomiz ...193919870913
demonstration of agglutinins for bartonella bacilliformis.1. methods of preparing a satisfactory antigen having been developed, a technique for performing an agglutination test with b. bacilliformis is made available. 2. as a result of repeated intravenous injection of living cultures of b. bacilliformis at short intervals, rabbits have been found to produce a high titre of specific agglutinins which, under the conditions obtaining in the present series of experiments, begins to decline after about one month following the last inoculation. 3. sera from ...194219871168
cervical lymphadenitis in a patient coinfected with toxoplasma gondii and bartonella henselae.cat scratch disease, caused by bartonella henselae, is a worldwide zoonosis that is most frequently associated with the bite or scratch of a kitten under 6 months of age, as well as from a fleabite. toxoplsma gondii is also another important zoonotic agent in cats and humans, which is mainly acquired by ingestion of food or water that is contaminated with oocytes shed by cats or by eating undercooked or raw meat containing tissue cysts. here, we report a first case of young patient with cervical ...201019874186
[cat scratch disease--an underestimated diagnosis].cat scratch disease is a rare and frequently underestimated cause of lymphadenopathy, which may occur also in the head and neck. the infection is most commonly caused by intracellular bacilli bartonella, transmitted by domestic animals.200919886535
detection of bartonella spp. in neotropical felids and evaluation of risk factors and hematological abnormalities associated with infection.although antibodies to bartonella henselae have been described in all neotropical felid species, dna has been detected in only one species, leopardus wiedii. the aim of this study was to determine whether dna of bartonella spp. could be detected in blood of other captive neotropical felids and evaluate risk factors and hematological findings associated with infection. blood samples were collected from 57 small felids, including 1 leopardus geoffroyi, 17 l. wiedii, 22 leopardus tigrinus, 14 leopa ...201019913372
detection of babesia canis subspecies and other arthropod-borne diseases in dogs from tirana, albania.summary. the importance of arthropod-borne diseases increased in the recent past in particular due to frequent travel with dogs in or by importing of dogs from regions with endemic occurrence of these diseases. while the epidemiological situation is well known for the western parts of the mediterranean, only limited data is available for eastern europe and the balkans. thirty clinically healthy dogs from suburban areas of tirana, albania, were tested for babesia canis, hepatozoon spp., leishmani ...200919915816
bartonella species detected in rodents and hedgehogs from algeria. 200919929978
molecular characterisation of resistance to rifampin in bartonella quintana. 200919929979
no etiological role for bartonella henselae infection in henoch schönlein purpura. 200919935277
detection and identification of bartonella sp. in fleas from carnivorous mammals in andalusia, spain.a total of 559 fleas representing four species (pulex irritans, ctenocephalides felis, ctenocephalides canis and spilopsyllus cuniculi) collected on carnivores (five iberian lynx lynx pardinus, six european wildcat felis silvestris, 10 common genet genetta genetta, three eurasian badger meles meles, 22 red fox vulpes vulpes, 87 dogs and 23 cats) in andalusia, southern spain, were distributed in 156 pools of monospecific flea from each carnivore, and tested for bartonella infection in an assay ba ...200919941605
[genetic diversity of ixodid tick-borne pathogens in tomsk city and suburbs].we studied two urban and two suburban biotypes of tomsk city for tick-transmitted diseases prevalence in naturally collected ticks. tick-borne encephalitis virus (tbev) was found in 6.5% of tick samples, west nile virus (wnv) in 2.2%, borrelia spp. in 8%, rickettsia spp. in 2.5%, and ehrlichia spp. in 1.7% of samples. genetic markers of powassan virus, bartonella spp., and balbesia spp. were not found. analysis of the genetic diversity of revealed pathogens resulted in the following conclusions: ...200919957906
association of bartonella species, feline calicivirus, and feline herpesvirus 1 infection with gingivostomatitis in cats.feline gingivostomatitis (fgs) is a common syndrome in cats; feline calicivirus (fcv), feline herpesvirus 1 (fhv-1), and bartonella species are common differential diagnoses. in this study, blood from 70 cats with fgs and 61 healthy control cats was tested for bartonella species antibodies in serum by enzyme-linked immunosorbent assay and western blot immunoassay and dna in blood using a conventional polymerase chain reaction assay. additionally, fresh oral biopsies from cats with fgs (n=42) and ...201019959386
bartonella rochalimae in raccoons, coyotes, and red foxes.to determine additional reservoirs for bartonella rochalimae, we examined samples from several wildlife species. we isolated b. rochalimae from 1 red fox near paris, france, and from 11 raccoons and 2 coyotes from california, usa. co-infection with b. vinsonii subsp. berkhoffii was documented in 1 of the coyotes.200919961681
molecular detection of bartonella henselae and bartonella clarridgeiae in clinical samples of pet cats from southern italy.bartonella henselae is considered an emerging pathogen of veterinary and medical interest that can be occasionally transmitted to humans. cats are considered to be the only reservoir host for b. henselae. in this study, we used a nested-pcr assay to investigate the prevalence of b.henselae and bartonella clarridgeiae dna in peripheral blood samples, fine needle lymph node aspirate specimens and oral swabs from 85 cats in order to develop an easy diagnostic strategy for the selection of infection ...201019963231
bartonella bacilliformis, endemic pathogen of the andean region, is intrinsically resistant to quinolones.to analyze the sequence of the region involved in the development of quinolone resistance of the gyra and parc genes in a series of bartonella bacilliformis isolates recovered prior to the introduction of quinolones, as well as one clinical isolate recovered in the 1970s, establishing the susceptibility levels to nalidixic acid and ciprofloxacin.201019969497
"interference" in mixed infections of bartonella and eperythrozoon in mice. 194119970549
discussion on the pathology and treatment of haemopathies, including leukaemias, of man and animals: the haemopathies of laboratory animals.the difference between haemopathies (which originate in the blood-forming tissues) and blood-diseases (which develop in the blood-stream) is explained and illustrated by examples and specimens.primary anaemia caused by the hyperplasia of the erythroblastic tissues in the marrow occurs in fowls as erythromyelosis. this condition can be experimentally transmitted, though inoculation in fowls may reproduce the anaemic disease, or give rise to a persistent polyerythrocythaemia. on farms erythromyelo ...193119988216
the bartonella and related parasites in man and animals (oroya fever and verruga peruviana): (section of tropical diseases and parasitology).through the investigations of noguchi on the one hand, and mayer and kikuth on the other, the unity of the aetiology of oroya fever and verruga peruviana has been demonstrated experimentally. the bartonella bacilliformis, the causal organism of oroya fever, belongs to a group of micro-organisms, the parasitic nature of which has been definitely proved during the last few years. tests with a view to transmitting the disease to monkeys, and the aetiology, clinical data, pathology, therapy and immu ...193419989875
[pandora's box: pathogens in ixodes ricinus ticks in central europe].among the various species of hard ticks, ixodes ricinus is the most frequently found tick throughout europe. as with other ixodid ticks, the developmental cycle runs through three stages. in each stage a blood meal is required in order to develop to the next stage. ixodes ricinus has been found to feed on more than 300 different vertebrate species. usually, larval ticks feed on small mammals such as mice and become infected with various microorganisms and viruses, of which some are substantial p ...200919998007
a groundhog, a novel bartonella sequence, and my father's death. 200919998749
bartonella henselae neuroretinitis in a 15-year-old girl with chronic myelogenous leukemia.a 15-year-old girl being treated with imatinib for chronic myelogenous leukemia (cml) presented with acute vision loss in her right eye accompanied by swelling of the right side of her neck. on examination, she was found to have disk and macular edema of the right eye. fine-needle aspiration and excisional biopsies of an enlarged submandibular lymph node were negative for malignancy. although initial serologies were equivocal for bartonella henselae, repeat serologies performed 1 week later upon ...200920006827
comparative activity of pradofloxacin, enrofloxacin, and azithromycin against bartonella henselae isolates collected from cats and a human.using bartonella henselae isolates from cats and a human, the activity of pradofloxacin was compared with those of enrofloxacin and azithromycin. by etest and disc diffusion assay, pradofloxacin showed greater antimicrobial activity than did other antibiotics. we conclude that pradofloxacin may prove useful for the treatment of b. henselae infections.201020007401
cat scratch disease presenting with a retroperitoneal abscess in a patient without animal contacts.cat scratch disease (csd) is usually diagnosed in patients presenting with regional lymphadenopathy and pyrexia that follow contacts with animals. we describe here a young adult male patient who presented with marked pyrexia and a retroperitoneal abscess without relevant medical histories, illustrating that csd can be a diagnostic challenge on selected occasions.200920012734
detection of bartonella tamiae dna in ectoparasites from rodents in thailand and their sequence similarity with bacterial cultures from thai patients.ectoparasites, including chigger mites (genera leptotrombidium, schoengastia, and blankarrtia) and one tick (genus haemaphysalis) collected from wild-caught rodents in thailand, were assessed for the presence of bartonella dna by using a polymerase chain reaction assay targeting the 16s-23s intergenic spacer region and citrate synthase gene (glta). of the 41 pooled samples tested, 34 were positive for bartonella dna. sequence analysis demonstrated that dna detected in 33 chigger mite pools and o ...201020017718
bartonellosis.bartonellosis is a constellation of clinical conditions affecting human beings and a variety of animals. many bartonella infections are zoonotic, with some of the most commonly reported zoonotic manifestations of infection including cat scratch disease, bacillary angiomatosis, endocarditis, and neuroretinitis. companion animals serve as reservoirs for several zoonotic species of bartonella, and may also serve as sentinels for zoonotic bartonella species harbored by wildlife. this article provide ...201020018462
prevalence of five pathogenic agents in questing ixodes ricinus ticks from western france.in europe, ixodes ricinus ticks are vectors of many emerging pathogens, including borrelia burgdorferi sensu lato (sl), anaplasma phagocytophilum, spotted fever group rickettsia sp., babesia sp., and very likely bartonella sp. in this study, we looked for the presence of dna of these microorganisms in 572 ticks from two forests in the west of france. dna extraction and polymerase chain reaction (pcr) amplification were performed on individual nymphal, male, and female i. ricinus ticks. amplifica ...201020020814
molecular mechanisms of bartonella henselae resistance to azithromycin, pradofloxacin and enrofloxacin. 201020022937
[bartonella henselae, an ubiquitous agent of proteiform zoonotic disease].bartonella henselae is the causative agent of cat scratch disease, a human infection usually characterized by persistent regional lymphadenopathy. it is transmitted to humans by cat scratches or bites. cats are the major reservoir for this bacterium thus b. henselae has a worldwide distribution. the bacterial pathogenicity may bay emphasized by the immune status of the infected host. angiomatosis or hepatic peliosis are the most frequent clinical manifestations in immunocompromised patients. b. ...201020042306
molecular detection of bartonella alsatica in european wild rabbits (oryctolagus cuniculus) in andalusia (spain).a sample of 279 european wild rabbits, oryctolagus cuniculus (141 males, 138 females), captured alive in andalusia (spain) and belonging to the two haplotype classes previously described for this species (230 and 49 corresponding with haplotypes a and b, respectively), were tested for the presence of bartonella alsatica dna. two species-specific nested polymerase chain reaction assays targeting for 16s-23s rrna intergenic spacer region and rna polymerase β subunit genes have been developed. fort ...201020059317
high prevalence of antibodies against bartonella henselae with cervical lymphadenopathy in children.cat-scratch disease is the most common form of bartonella henselae infection. although reports have shown that csd is relatively common, they have not shown the prevalence of seropositivity for bartonella henselae in cases of cervical lymphadenitis and kawasaki disease, which are relatively common diseases in children.201020059723
prevalence of bartonella henselae and borrelia burgdorferi sensu lato dna in ixodes ricinus ticks in europe.bartonella spp. can cause persistent bloodstream infections in humans and animals. to determine whether bartonella henselae is present in questing ixodes ricinus ticks, we analyzed the prevalence of b. henselae dna among tick stages compared to the prevalence of dna from borrelia burgdorferi sensu lato, the pathogen most frequently transmitted by ticks. b. henselae dna was present with a prevalence of up to approximately 40% in tick populations sampled in four european sites (eberdingen, germany ...201020061459
blood cell findings resembling bartonella spp.some bartonella species are able to invade red blood cells (rbc) and may cause persistent infection in the susceptible host. use of transmission electron microscopy (tem) demonstrates, inside erythrocytes, the typical triple-walled agents. however, when examining ultrathin sections of blood cells, the authors have, on several occasions, detected intraerythrocytic abnormalities that mimic but are not typical of bartonella spp. small endovesicles, pseudoinclusions, cavities, and irregular hemoglob ...201020070147
scalp eschar and neck lymphadenopathy caused by bartonella henselae after tick bite.rickettsia slovaca and rickettsia raoultii have been associated with a syndrome characterized by scalp eschar and neck lymphadenopathy following tick bites. however, in many cases, the causative agent remains undetermined. we report 3 cases of this syndrome caused by bartonella henselae, and we propose the term "senlat" to collectively describe this clinical entity.201020070235
renal microabscesses due to bartonella infection.we report a case of cat scratch disease with bilateral renal microabscesses. this case is unique in that there were no other abscesses found intrabdominally. a previously healthy child was admitted with a 12-day history of fever and headaches. bartonella henselae titers were initially igg 1:640 and igm 1:100, and later igg >1:2560 and igm >1:800. an abdominal ultrasound examination was normal but ct scan revealed microabscesses in both kidneys.201020072078
peliosis hepatis in cats is not associated with bartonella henselae infections.peliosis hepatis is a vasculoproliferative disorder of the liver with infectious and noninfectious causes. in humans and dogs, bartonella henselae has been linked to peliosis hepatis. although domestic cats are the natural reservoir of b. henselae and although peliosis hepatis is common in this species, an association between this condition and infection with b. henselae has never been investigated in cats. in this study, 26 cases of peliosis hepatis in cats were tested for b. henselae infection ...201020080497
bartonella sp. infection of voles trapped from an interior alaskan site where ticks are absent.to determine whether bartonella species may perpetuate in sites where ticks are absent, we analyzed blood and spleen samples from small mammals trapped near cantwell, alaska during september 1999. blood smears from seven of 48 myodes (clethrionomys) rutilus suggested a bartonella species infection; five of the seven yielded cultures consistent with bartonella species; pcr of rrs, glta, and rpob genes confirmed bartonella infection in four of these culture samples. phylogenetic analysis of rrs, g ...201020090030
detection of bartonella species in small mammals from zhejiang province, china.to estimate the prevalence of bartonella in small mammals of different species, during different seasons, and at different study sites, and to provide baseline data for the risk assessment of human bartonella infection, we captured small mammals using snap traps in zhejiang province, china. bartonella species were detected in small-mammal samples by polymerase chain reaction and positive amplicons were sequenced. bartonella dna was detected in 47% (90/192) of apodemus agrarius, 31% (14/45) of ra ...201020090031
murine model for bartonella birtlesii infection: new aspects.as a model of persistent infection, various aspects of bartonella birtlesii infection in laboratory mice, including some immunodeficient mice, are presented, particularly focusing on conditions mimicking natural infection. bacteraemia was explored using different mice strains routes and inoculum doses (3.4-5x10(7)cfu/mouse). mice became bacteraemic for 5 (c57bl6/6) to 10 weeks (balb/c, swiss) with peaks ranging from 2x10(3) to 10(5)cfu/ml of blood. the id route induced the most precocious bacter ...201020097421
evaluation of brain tissue or cerebrospinal fluid with broadly reactive polymerase chain reaction for ehrlichia, anaplasma, spotted fever group rickettsia, bartonella, and borrelia species in canine neurological diseases (109 cases).vector-transmitted microorganisms in the genera ehrlichia, anaplasma, rickettsia, bartonella, and borrelia are commonly suspected in dogs with meningoencephalomyelitis (mem), but the prevalence of these pathogens in brain tissue and cerebrospinal fluid (csf) of dogs with mem is unknown.201020102497
a toddler with facial nodules: a case of idiopathic facial aseptic granuloma.we describe the case of a 3-year-old boy who presented with several asymptomatic facial nodules present for six months. a skin biopsy obtained from the nodules showed a moderately well-defined granuloma in the superficial and deep dermis. a squamous epithelial lined cyst, extravasated keratin, or shadow cells were not identified. bartonella henselae titers and the coccidioidomycosis immitis immunodiffusion test were negative; a tuberculin skin test was non-reactive. fite, periodic acid-schiff (p ...201020137751
feline immunodeficiency virus, feline leukemia virus and bartonella species in stray cats on st kitts, west indies.stray cats trapped in various areas of basseterre, the capital of st kitts in the west indies, were tested for infection with feline immunodeficiency virus (fiv) and feline leukemia virus (felv) using commercial kits. of 99 (51 male and 48 female) cats trapped in 2006/7, 15% (12 males and three females) were positive for fiv while none were positive for felv. of 72 (41 males and 31 females) cats trapped in 2009, 14% (nine males and one female) were positive for fiv while none were positive for f ...201020138558
successful treatment of bartonella henselae endocarditis in a cat.this report describes the clinical presentation, diagnosis and treatment of a cat with vegetative valvular endocarditis temporally associated with natural infection with bartonella henselae. lethargy, abnormal gait and weakness were the main clinical signs that resulted in referral for diagnostic evaluation. using a novel and sensitive culture approach, b henselae was isolated from the blood. following antibiotic therapy there was total resolution of clinical signs, the heart murmur, the valvula ...201020138559
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