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bartonella henselae in the human environment in poland.the aim of the study was to determine the occurrence of bartonella henselae reservoir and vectors of infection in the close surroundings of human beings in urban areas of central poland. the study included mammals (54 dogs, 137 cats) and 102 adult ixodes ricinus ticks removed from cats and dogs. blood samples were drawn from each animal and cultured on chocolate agar plates and in mouse fibroblasts l-929 cell line culture. the levels of bartonella henselae igg antibodies were determined by indir ...200717852890
high bartonella spp. seroprevalence in a swedish homeless population but no evidence of trench fever.blood samples and epidemiological data were collected from 50 homeless patients in central stockholm, sweden. sera were analysed for antibodies to b. henselae, b. quintana, b. elizabethae and b. grahamii. whole blood was cultured and used as substrate for a newly developed quantitative real time polymerase chain reaction (qpcr) specifically targeting bartonella spp. dna. 61 matched blood donor sera were used as controls. homeless patients were significantly more often seropositive to bartonella ...200817852922
identification of bacteria from clinical samples using bartonella alpha-proteobacteria growth medium.in an effort to overcome historical problems associated with the isolation of bartonella species from animal and human blood samples, our laboratory developed a novel, chemically modified, insect-based, liquid culture medium (bartonella alpha-proteobacteria growth medium, bapgm). in this study, we describe the isolation of non-bartonella bacteria from aseptically obtained human blood and tissue samples that were inoculated into bapgm pre-enrichment culture medium, and were obtained during attemp ...200717889384
discovery and analysis of bartonella henselae antigens for use in clinical serologic assays.the antibody response to bartonella henselae has been studied in a number of mammals; however, the human response needs to be further studied. after natural infection, humans have antibody reactivity to a large number of b. henselae proteins. we used a proteomic approach to identify antigenic proteins of b. henselae to determine their capacity to elicit a human antibody response. comparing patient sera by western blot analysis demonstrated significant amounts of reactivity to b. henselae. the im ...200817889484
a view on bartonella quintana endocarditis--confirming the molecular diagnosis by specific fluorescence in situ hybridization.culture-negative endocarditis is a frequent problem in cardiology, especially if caused by fastidious organisms. among these, the diagnostic tools for the detection of bartonella quintana are still unsatisfactory. in a culture-negative case of suspected endocarditis undergoing aortic valve replacement, polymerase chain reaction amplification and sequencing of the 16s rrna gene indicated b. quintana infection. to develop a new diagnostic tool, independent from culture and amplification techniques ...200817889492
infective endocarditis with negative blood cultures.culture-negative endocarditis is important as it has a relatively poor prognosis. the principal reason for negative cultures is prior antibiotic therapy although fastidious organisms such as bartonella spp. and coxiella burnetii are also important. pcr may offer significant advantages in diagnosis but tests require standardisation. modification of current diagnostic criteria is required. empirical cover of mrsa needs to be considered.200717890062
[evaluation of a in house serology reagent for the diagnosis of cat-scratch disease defined by pcr].evaluate the sensitivity and the specificity of the cat scratch disease serology by indirect immunofluorescence assay, realized from an in-house antigenic suspension, with pcr defined cases. describe the epidemiological characteristics of the cases.200717905531
[hematozoon cenoses of small rodents and insectivora in the orenburg region].a total of 2942 specimens of 15 species of ground rodents and insectova in the orenburg region were caught and examined during long-term studies. the investigators detected 7 taxonomic groups of hematozoons: rickettsia (anaplasma sp., grahamella sp., haemobartonella sp.), protozoa (trypanosoma sp., plasmodium sp., piroplasma sp.), and nematodes (filariidae spp., larval stages). the authors give information on the species composition and infection extensiveness of individual systematic groups of ...200717912832
cat-scratch disease lymphadenitis. 200717915663
the use of bartonella henselae-specific age dependent igg and igm in diagnostic models to discriminate diseased from non-diseased in cat scratch disease serology.cat scratch disease (csd) is caused by bartonella henselae infection and is a common cause of regional lymphadenopathy. the diagnosis of csd largely depends on serology, but is hampered by both low sensitivity and specificity of the applied igg and igm assays. using an in-house elisa, we detected a significant age-dependent increase in the igg levels in the general population compared to csd patients. with this knowledge, we developed diagnostic models to differentiate diseased from non-diseased ...200717916395
bartonella and rickettsia from fleas (siphonaptera: ceratophyllidae) of prairie dogs (cynomys spp.) from the western united states.fleas of prairie dogs have been implicated in the transmission of bartonella spp. we used pcr to test dna extracts from 47 fleas of prairie dogs from 6 states. we amplified dna from 5 unique genotypes of bartonella spp. and 1 rickettsia sp. from 12 fleas collected in north dakota, oklahoma, texas, and wyoming. sequences from the bartonella spp. were similar, but not identical, to those from prairie dogs and their fleas in colorado.200717918386
prevalence of antibodies to bartonella henselae in dogs in italy. 200717921442
a case of fatal disseminated bartonella henselae infection (cat-scratch disease) with encephalitis.cat-scratch disease resulting from bartonella henselae infection is usually a benign, self-limited process in immunocompetent children. even the rare cases associated with neurologic manifestations are not generally fatal. we report a case of a previously healthy 6-year-old boy with cat-scratch disease, systemic dissemination, and encephalitis that led to his death. autopsy revealed perivascular lymphocytic infiltrates and microglial nodules in the brain. to our knowledge, this finding has not b ...200717922599
bivalvular bartonella henselae prosthetic valve endocarditis.prosthetic valve endocarditis is an uncommon manifestation of infection with bartonella species. herein, we report a case of bartonella henselae endocarditis involving prosthetic mitral and aortic valves. the patient had a favorable outcome with combined medical and surgical therapy. concomitant crescentic glomerulonephritis led to an initial mistaken diagnosis of wegener's granulomatosis.200717942646
genetic diversity of bartonella henselae in human infection detected with multispacer typing.we applied multispacer typing (mst) by incorporating 9 variable intergenic spacers to bartonella henselae dna detected in lymph node biopsy specimens from 70 patients with cat-scratch disease (csd), in cardiac valve specimens from 2 patients with endocarditis, and in 3 human isolates from patients with bacillary angiomatosis, csd, and endocarditis. sixteen mst genotypes were found, 5 previously identified in cats and 11 new. of the studied dna, 78.7% belonged to 2 genotypes, which were phylogene ...200717953088
osler's nodes and janeway lesions.the pathogenesis of osler's nodes and janeway lesions remains a mystery despite vigorous debate over the last 113 years. they are given great emphasis among the clinical signs of bacterial endocarditis but are seldom seen in practice. two cases of subacute bacterial endocarditis are presented. a 66-year-old woman with bartonella henselae endocarditis developed osler's nodes on the hands postoperatively, and a 23-year-old man with streptococcus oralis endocarditis developed tender macules with an ...200717956487
[cat-scratch disease]. 200717969956
multifocal osteomyelitis due to bartonella henselae in a child without focal pain.we describe a case of an 11-year-old girl who presented with osteomyelitis of the vertebrae and right femur due to bartonella henselae. her only symptom was prolonged fever without focal pain. magnetic resonance imaging (mri) and nested polymerase chain reaction (pcr) were useful for the diagnosis. osteomyelitis due to b. henselae should be considered in cases of prolonged fever of unknown origin.200717982727
phylogenetic analysis of bartonella detected in rodent fleas in yunnan, china.previous studies have demonstrated a diversity of bartonella spp. in rodent populations in yunnan province, china. although bartonella spp. have been isolated from cat fleas and cattle ticks collected from their animal hosts, little is known about bartonella carried by rodent fleas. in this study, bartonella dna was detected by polymerase chain reaction (pcr) in two of five species of rodent fleas. these included xenopsylla cheopis and ctenophthalmus lushuiensis, which were collected from rattus ...200717984255
pcr for bacterial 16s ribosomal dna in multiple sclerosis cerebrospinal fluid.the cause of multiple sclerosis (ms) is currently unknown. the hypothesis of this study is that ms is caused by a chronic bacterial infection of the central nervous system (cns) and the ensuing immune response. we developed a sensitive two-stage polymerase chain reaction method using nested or semi-nested primers specific for the bacterial 16s ribosomal dna to test for the presence of bacterial dna in cerebrospinal fluid. we designed seven sets of primers to amplify dna from spirochetes , campyl ...200817986505
spatial analysis of the exposure of dogs in rural north-coastal california to vectorborne pathogens.between 0 and 50 per cent of the dogs in eight rural villages in far northern california with a high risk of tickborne diseases were seropositive for anaplasma phagocytophilum and bartonella vinsonii subspecies berkhoffii, and between 0 and 10 per cent were seropositive for borrelia burgdorferi. the odds ratio for the co-exposure of individual dogs to b vinsonii berkhoffii and a phagocytophilum was 18.2. none of the diseases was associated with the sex of the dogs, whether they slept out of door ...200717993656
surveillance for zoonotic vector-borne infections using sick dogs from southeastern brazil.for many vector-borne organisms, dogs can be used as sentinels to estimate the risk of human infection. the objective of this study was to use dogs as sentinels for multiple vector-borne organisms in order to evaluate the potential for human infection with these agents in southeastern brazil. blood from 198 sick dogs with clinicopathological abnormalities consistent with tick-borne infections were selected at the são paulo state university veterinary teaching hospital in botucatu and tested for ...200718021025
[cat scratch disease: report of a case]. 200718021527
immunological response in cases of complicated and uncomplicated bartonellosis during pregnancy.bartonellosis (carrion's disease) during pregnancy is associated with high rates of maternal and perinatal mortality. we report the immunological patterns in two cases of human bartonellosis during pregnancy. one patient had an uncomplicated course while the second patient developed life threatening anasarca and cardiac tamponade. the patient with a complicated course had a th1 response with a higher elevation of il-10. this elevation has been associated with poor outcome pregnancies during bact ...200718026643
genomic analysis of bartonella identifies type iv secretion systems as host adaptability factors.the bacterial genus bartonella comprises 21 pathogens causing characteristic intraerythrocytic infections. bartonella bacilliformis is a severe pathogen representing an ancestral lineage, whereas the other species are benign pathogens that evolved by radial speciation. here, we have used comparative and functional genomics to infer pathogenicity genes specific to the radiating lineage, and we suggest that these genes may have facilitated adaptation to the host environment. we determined the comp ...200718037886
encephalopathy with retinitis due to cat-scratch disease.cat-scratch disease is one of several diseases known to be caused by bartonella species. some infections due to bartonella resolve spontaneously without treatment with antibiotics, but in other cases the disease can be fatal without treatment. this case study reports a 7-year-old male who presented with an unexplained encephalopathy and unusual retinal findings associated with evidence supporting infection by b. henselae. the 7-year-old male presented with a 2-week history of general malaise and ...200718039241
detection of rickettsia amblyommii in association with a tick bite rash.in the summer of 2006, an amblyomma americanum tick was removed from a woman in central north carolina, who subsequently developed a rash at the site of tick attachment. when examined by polymerase chain reaction (pcr) for borrelia, anaplasma, ehrlichia, babesia, rickettsia, and bartonella dna, only the rickettsia primers generated an amplicon, which was identified as "r. amblyommii" by sequencing. to our knowledge, this is the first case in which r. amblyommii was temporally associated with a r ...200718052716
diversifying selection and concerted evolution of a type iv secretion system in bartonella.we have studied the evolution of a type iv secretion system (t4ss), in bartonella, which is thought to have changed function from conjugation to erythrocyte adherence following a recent horizontal gene transfer event. the system, called trw, is unique among t4sss in that genes encoding both exo- and intracellular components are located within the same duplicated fragment. this provides an opportunity to study the influence of selection on proteins involved in host-pathogen interactions. we seque ...200818065487
[using direct enzyme linked immunosorbent assay for the detection of igg antibody on bartonella henselae among healthy people in changping, beijing].to detect bartonella henselae igg antibody among healthy people in changping, beijing.200718069561
a sacb mutagenesis strategy reveals that the bartonella quintana variably expressed outer membrane proteins are required for bloodstream infection of the host.bartonella bacteria adhere to erythrocytes and persistently infect the mammalian bloodstream. we previously identified four highly conserved bartonella quintana adhesin genes that undergo phase variation during prolonged bloodstream infection. the variably expressed outer membrane proteins (vomp) encoded by these genes are members of the trimeric autotransporter adhesin family. each b. quintana vomp appears to contribute a different adhesion phenotype, likely mediated by the major variable regio ...200818070893
bartonella tamiae sp. nov., a newly recognized pathogen isolated from three human patients from thailand.three strains of a novel bartonella species (bartonella tamiae) were isolated from human patients from thailand. sequence analysis of six chromosomal regions (16s rrna, glta, groel, ftsz, rpob, and the intergenic spacer region) and phenotypical analysis supported the similarity of the three strains and placed them within the genus bartonella separately from previously described species.200818077632
vector-borne infections in cats: molecular study in barcelona area (spain).previous serological surveys have reported the presence of different organisms in cats from spain but little reports exist about the exact identity of these organisms. the purpose of the study reported here was to assess the presence of dna of several vector-borne infections in a population of cats from barcelona area. one hundred blood samples obtained from cats admitted to the uab-vth were entered into the study and classified as healthy (n=48) or unhealthy (n=52). edta-blood samples were assa ...200818079064
[stroke as a manifestation of acute bartonella henselae endocarditis].bartonella, a small gram-negative bacillus, causes a variety of diseases and presents with different clinical manifestations, one of which is infective endocarditis (ie). ie due to b. henselae is associated with a high risk of morbidity and mortality due to the destructive potential of the organism to the heart valves and due to the great risk of embolic complications.200718087840
do bartonella infections cause agitation, panic disorder, and treatment-resistant depression?bartonella is an emerging infection found in cities, suburbs, and rural locations. routine national labs offer testing for only 2 species, but at least 9 have been discovered as human infections within the last 15 years. some authors discuss bartonella cases having atypical presentations, with serious morbidity considered uncharacteristic of more routine bartonella infections. some atypical findings include distortion of vision, abdominal pain, severe liver and spleen tissue abnormalities, throm ...200718092060
isolation and characterization of bartonella bacilliformis from an expatriate ecuadorian.carrion's disease is typically biphasic with acute febrile illness characterized by bacteremia and severe hemolytic anemia (oroya fever), followed by benign, chronic cutaneous lesions (verruga peruana). the causative agent, bartonella bacilliformis, is endemic in specific regions of peru and ecuador. we describe atypical infection in an expatriate patient who presented with acute splenomegaly and anemia 3 years after visiting ecuador. initial serology and pcr of the patient's blood and serum wer ...200818094131
molecular method for bartonella species identification in clinical and environmental samples.a new, efficient molecular method for detection of bartonella, based on the 16s-23s rrna intergenic spacer and 16s rrna amplification by multiplex pcr combined with reverse line blotting, was designed. this assay could simultaneously detect 20 different known species and other bartonella species not described previously.200818094134
multi-locus sequence typing of bartonella henselae isolates from three continents reveals hypervirulent and feline-associated clones.bartonella henselae is a zoonotic pathogen and the causative agent of cat scratch disease and a variety of other disease manifestations in humans. previous investigations have suggested that a limited subset of b. henselae isolates may be associated with human disease. in the present study, 182 human and feline b. henselae isolates from europe, north america and australia were analysed by multi-locus sequence typing (mlst) to detect any associations between sequence type (st), host species and g ...200718094753
bartonella henselae infects human erythrocytes.bartonella henselae, a facultative intracellular bacterium, has been known as the agent of cat scratch disease, bacillary angiomatosis, peliosis hepatis, endocarditis, and bacteremic syndrome in humans. bartonella species can cause intraerythrocytic infections and have been isolated from the bloodstream of patients by several methods. it was demonstrated that b. bacilliformis and b. quintana infect human endothelial cells and human erythrocytes and b. henselae infects erythrocytes of cats. the a ...200718098053
severe anemia, panserositis, and cryptogenic hepatitis in an hiv patient infected with bartonella henselae.bartonella spp. constitute emerging pathogens of worldwide distribution. bacillary angiomatosis is the most frequent skin manifestation of bartonelloses; nevertheless, b. henselae infection should always be considered systemic, especially in immunodeficient individuals. the authors report the case of an aids patient with bacillary angiomatosis, who had concurrent severe anemia, hepatitis, peritonitis, pleuritis, and pericarditis. clinical manifestation, electronic microscopic examination of eryt ...200718098054
[not available]. 194818102713
[not available]. 194818105234
effect of roentgen rays upon bartonella-infected and normal rats. 194918108572
cutaneous manifestations of some tropical diseases. 194918113615
[not available]. 194918116737
bacillary angiomatosis in an hiv-positive man with multiple risk factors: a clinical and epidemiological puzzle.a 36-year-old man with advanced aids presented with skin lesions, fever and weight loss. physical examination revealed skin lesions suggestive of bacillary angiomatosis. diagnostic imaging identified bone lesions, soft tissue masses and a single hepatic lesion. his clinical presentation was most consistent with bartonella quintana; however, his risk for infection with b quintana was limited to a remote, brief period of homelessness. in contrast, his frequent contact with cats presented substanti ...200518159553
prevalence of ehrlichia canis, anaplasma platys, babesia canis vogeli, hepatozoon canis, bartonella vinsonii berkhoffii, and rickettsia spp. in dogs from grenada.to identify the tick-borne pathogens in dogs from grenada, we conducted a serologic survey for ehrlichia canis in 2004 (104 dogs) and a comprehensive serologic and molecular survey for a variety of tick-borne pathogens in 2006 (73 dogs). in 2004 and 2006, 44 and 32 dogs (42.3% and 43.8%) were seropositive for e. canis, respectively. in 2006, several tick-borne pathogens were identified by serology and pcr. dna of e. canis, anaplasma platys, babesia canis vogeli, hepatozoon canis, and bartonella ...200818160223
bacillary angiomatosis in a patient with chronic lymphocytic leukemia.bacillary angiomatosis is a cutaneous or visceral infection with bartonella henselae or bartonella quintana. cases usually occur in hiv infected individuals. we present a 60-year-old man with chronic lymphocytic leukemia and neutropenic fever caused by bacillary angiomatosis. the nine ba cases in oncology patients are reviewed.200818165862
[a case of cat scratch disease].cat scratch disease (csd) which is usually seen in children and young adults and characterized by self limited lymphadenopathy, is caused by bartonella henselae. in this report, a 30-year-old male patient who was admitted to the outpatient clinic with the complaint of lymphadenopathy, was presented. erythrocyte sedimentation rate and c reactive protein values of the patient were normal, and anti-hiv, brucella agglutination and anti-toxoplasma igm and igg tests were negative. no bacterial growth ...200718173081
temporal and spatial patterns of bartonella infection in black-tailed prairie dogs (cynomys ludovicianus).we describe the temporal dynamics and spatial distribution of bartonella in black-tailed prairie dogs (cynomys ludovicianus) based on a longitudinal study conducted in 20 black-tailed prairie dog (btpd) colonies in boulder county, co from 2003 to 2005. bartonella infection was widely distributed in all colonies with an overall prevalence of 23.1%, but varied by colony from 4.8% to 42.5% and by year from 9.1 to 39.0%, with a marked increase in bartonella activity in 2005. levels of bacteremia var ...200818176820
[stellar neuroretinitis and bartonella henselae infection. a case report without exposure to cats]. 200818187281
musculoskeletal manifestations of cat scratch disease.musculoskeletal manifestations (mms) are considered to be rare in cat scratch disease (csd) and are not well characterized. we aimed to study mms of csd.200718190312
from cat scratch disease to bartonella henselae infection. 200718190313
detection of bartonella bovis in a cattle herd in italy. 200818192660
bacterial communities of bartonella-positive fleas: diversity and community assembly patterns.we investigated the bacterial communities of nine bartonella-positive fleas (n = 6 oropsylla hirsuta fleas and n = 3 oropsylla montana fleas), using universal primers, clone libraries, and dna sequencing. dna sequences were used to classify bacteria detected in a phylogenetic context, to explore community assembly patterns within individual fleas, and to survey diversity patterns in dominant lineages.200818203862
ciclosporin-induced fibrovascular polyps vs. bacillary angiomatosis. 200818205872
hepatosplenic cat-scratch fever. 200818222165
genetic diversity and phylogenetic relationships of bacteria belonging to the ochrobactrum-brucella group by reca and 16s rrna gene-based comparative sequence analysis.the genetic diversity and phylogenetic interrelationships among 106 ochrobactrum strains (o. anthropi: 72, o. intermedium: 22, o. tritici: 5, o. oryzae: 2, o. grignonense: 2, o. gallinifaecis: 1, o. lupini: 2), the type strains of the eight brucella species and other closely related taxa were studied by reca and rrs gene (16s rrna) comparative sequence analysis. both markers correctly delineated the various ochrobactrum species; however, resolution at the subspecies level was considerably higher ...200818222618
characterization of bartonella strains isolated from black-tailed prairie dogs (cynomys ludovicianus).thirty bartonella strains were isolated from the blood of black-tailed prairie dogs (cynomys ludovicianus) from boulder county, colorado, usa. the bacteria appeared as small, fastidious, aerobic, gram-negative rods. the partial sequences of the citrate synthase gene (glta) demonstrated five unique genetic variants. phylogenetic analysis based on sequences of glta, 16s rrna, rpob, ftsz, and ribc showed that the black-tailed prairie dog-related bartonella variants comprise a distinct monophyletic ...200818237261
attention: attention-deficit/ hyperactivity disorder. 200818240846
endocarditis in cattle caused by bartonella bovis.this study aimed to determine the role of bartonella as an endocarditis agent in cattle. bartonella bovis was identified by pcr, gene sequences analysis, and specific internal transcribed spacer amplicon product size in 2 bovine endocarditis cases with high antibody titers, which demonstrates that b. bovis is a pathogen for cattle.200718252116
isolation of bartonella sp. from sheep blood.a bartonella sp. was isolated from sheep blood. bacterial identification was conducted by using electron microscopy and dna sequencing of the 16s rrna, citrate synthase, riboflavin synthase, and rnaase p genes. to our knowledge, this is the first report of ovine bartonella infection.200718258009
bartonella dna in dog saliva.bartonella species, transmitted by arthropods or animal bites and scratches, are emerging pathogens in human and veterinary medicine. pcr and dna sequencing were used to test oral swabs collected from dogs. results indicated the presence of 4 bartonella species: b. bovis, b. henselae, b. quintana, and b. vinsonii subspecies berkhoffii.200718258056
bartonella australis sp. nov. from kangaroos, australia. 200718258063
prolonged bartonella henselae bacteremia caused by reinfection in cats.we analyzed the genetic relatedness of blood culture isolates of bartonella henselae from 2 cats of patients with cat-scratch disease at admission and after 12 months. isolates from each cat at different times were clonally unrelated, which suggested reinfection by a second strain.200818258096
co-circulating microorganisms in questing ixodes scapularis nymphs in maryland.ixodes scapularis can be infected with borrelia burgdorferi, anaplasma phagocytophilum, bartonella spp., babesia microti, and rickettsia spp., including spotted-fever group rickettsia. as all of these microorganisms have been reported in maryland, the potential for these ticks to have concurrent infections exists in this region. to assess the frequency of these complex infections, 348 i. scapularis nymphs collected in 2003 were screened for these microorganisms by pcr with positives being confir ...200718260514
[ocular bartonellosis: report of three clinical cases].the characteristic clinical presentation of cat scratch disease is subacute regional lymphadenopathy; nevertheless, 5-25% of bartonella henselae infections may present an atypical or systemic form, with potential eye involvement. we describe three clinical cases of ocular bartonellosis in two adolescents and one young adult, who had close contact with cats; all of them presented persistent fever ranging from 15 to 21 days, and two of them developed a sudden unilateral loss of visual acuity assoc ...200818273527
detection of two bartonella tamiae-like sequences in amblyomma americanum (acari: ixodidae) using 16s-23s intergenic spacer region-specific primers.four hundred and sixty-six questing amblyomma americanum (l.) (acari: ixodidae) from carolina county, va, and 98 questing a. americanum from chatham county, nc, were screened by polymerase chain reaction (pcr) for the bartonella 16s-23s intergenic spacer region. two amplicons, approximately 270-280 bp, were detected in two ticks from virginia. based upon pcr and sequencing, an adult male and adult female tick harbored dna sequences closely related to bartonella tamiae (dq395180). bartonella dna ...200818283962
infectious diseases of dogs and cats on isabela island, galapagos.vaccination and importation of dogs and cats are prohibited in the galapagos, resulting in a uniquely isolated population. the purpose of this study was to determine the prevalence of infectious diseases of dogs and cats that impact their health, could spill over to native wildlife, or sentinel diseases of concern to humans.200818289290
bartonella dna in the blood and lymph nodes of golden retrievers with lymphoma and in healthy controls.although lymphoma is the most common neoplastic process reported in dogs, its precise etiology is unknown. golden retrievers are more likely to develop lymphoma, suggesting a breed predisposition; however, other factors, including environment, immunity, and infection, are likely contributors to oncogenesis.200818289294
lymphadenopathy in a novel mouse model of bartonella-induced cat scratch disease results from lymphocyte immigration and proliferation and is regulated by interferon-alpha/beta.in immunocompetent humans, cat scratch disease (csd) is elicited by the gram-negative bacterium bartonella henselae and is characterized by a benign regional lymphadenopathy, the pathogenesis of which is poorly understood. here, we describe a novel mouse model of bartonella-induced csd-like disease that allowed us to investigate the mechanisms leading to lymphadenopathy in vivo. in wild-type mice, a subcutaneous inoculation of either viable or inactivated b. henselae led to a strong swelling of ...200818292236
serological evidence of bartonella henselae infection in healthy people in catalonia, spain.cat scratch disease (csd), bacillary angiomatosis, hepatic peliosis and some cases of bacteraemia, endocarditis, and osteomyelitis are directly caused by some species of the genus bartonella. the purpose of this study was to determine the prevalence of igg antibodies against bartonella henselae in healthy people and to identify the epidemiological factors involved. serum samples from 218 patients were examined by indirect immunofluorescence assay (ifa). significance levels for univariate statist ...200818294428
feline bartonellosis and cat scratch disease.bartonella species are important emerging zoonotic pathogens. transmission of these organisms in nature may be much more complex than is currently appreciated. cats can be infected with five bartonella species, including, bartonella henselae, bartonella clarridgeae, bartonella bovis, bartonella koehlerae and bartonella quintana. in addition to cats, numerous domestic and wild animals, including bovine, canine, human, and rodent species can serve as chronically infected reservoir hosts for variou ...200818295347
molecular evidence of bartonella dna in ixodid ticks in czechia.we report the development of a novel method for detection of bartonella dna in ixodid ticks. the assay is based on a specific amplification of a part of 16s rrna gene and 16s-23s rrna intergenic spacer region of bartonella sp. by nested pcr and southern blot hybridization with specific dna probe; the method is highly sensitive and specific. the screening of 327 unfed ticks collected in different urban and suburban areas of czechia in 2003-2005 revealed the presence of bartonella dna in four ixod ...200718298048
hepatic granulomas: histological and molecular pathological approach to differential diagnosis--a study of 442 cases.the incidence of hepatic granulomas is reported in 2-15% of liver biopsies. this study was carried out to evaluate the incidence and aetiology of hepatic granulomas in a german institute of pathology with specialization in liver diseases.200818312287
bartonella native valve endocarditis: the first brazilian case alive and well.bartonella is an important cause of blood culture-negative endocarditis in recent studies. seroprevalence studies in the states of minas gerais and rio de janeiro have shown bartonella igg positivity around 14% in healthy adults and 40% in hiv seropositive adults, respectively. a case report of a 46-year-old white male with moderate aortic regurgitation (ar) due to rheumatic heart disease (rhd), admitted due to worsening heart failure, is presented. clinical features were apyrexia, anemia, polyc ...200718327472
heterogeneity of susceptibility to fluoroquinolones in bartonella isolates from australia reveals a natural mutation in gyra.bartonella sp. are intracellular bacteria associated with an increasing number of clinical manifestations but with few published data on in vitro susceptibility testing of antibiotics. our objective was to evaluate in vitro antibiotic susceptibilities of 20 new bartonella isolates from animals in australia.200818334491
detection of bartonella henselae in the blood of 2 adult horses.bartonella spp. are emerging zoonotic agents that have been found in a wide variety of domestic animals and wildlife and cause a number of clinical syndromes. bartonella sp. infection has been identified in a growing number of animal species, including cats, rodents, porpoises, and canids, but has not been reported in horses.200818346149
abscess-forming lymphadenopathy and osteomyelitis in children with bartonella henselae infection.bartonella henselae is the agent of cat-scratch disease (csd), a chronic lymphadenopathy among children and adolescents. a systemic infection is very rare and most of these cases are found in patients with immunodeficiency. here, cases involving four children of 6-12 years of age are reported. three of the children had an abscess-forming lymphadenopathy and surrounding myositis in the clavicular region of the upper arm. the diagnosis was made serologically and, in one case, using eubacterial uni ...200818349375
molecular characterization of bartonella vinsonii subsp. berkhoffii genotype iii.the molecular characterization of a bartonella vinsonii subsp. berkhoffii genotype iii strain (ncsu strain 06-co1) isolated from the blood of a military working dog diagnosed with endocarditis is reported in this study. several genes were amplified and sequenced for comparative sequence similarity with other strains.200818367567
[a high prevalence of antibodies against bartonella and babesia microti has been found in villages and urban populations in cordoba, colombia].establishing seroprevalence against bartonella and babesia microti in arural population exposed and/or non-exposed to domestic animals in cordoba,colombia.200818368229
bartonella endocarditis in complex congenital heart disease.bartonella species are an important cause of culture-negative endocarditis, with recognized risk factors of alcoholism, homelessness, cat exposure, and pre-existing valvular disease. we report a case of bartonella henselae endocarditis in a 36-year-old woman with complex congenital heart disease who presented with a 7-month history of hemolytic anemia, leukocytoclastic vasculitis, and recurrent fevers. transesophageal echocardiogram revealed vegetations on the patient's native aortic valve and i ...200718377522
giant pyogenic granuloma of the thigh: a case report.pyogenic granuloma or lobular capillary hemangioma remains an etiopathological enigma, with trauma, inflammatory and infectious agents being the commonest suspected causative agents. these lesions affect mucous membranes of the upper aero-digestive tract, and skin. hiv patients diagnosed with pyogenic granuloma present with multiple lesions, caused by bartonella spp.200818377654
atypical bartonella hensalae chorioretinitis in an immunocompromised patient.to report an atypical case of chorioretinopathy in a patient with bilateral renal transplantations.200818379943
vector transmission of bartonella species with emphasis on the potential for tick transmission.bartonella species are gram-negative bacteria that infect erythrocytes, endothelial cells and macrophages, often leading to persistent blood-borne infections. because of the ability of various bartonella species to reside within erythrocytes of a diverse number of animal hosts, there is substantial opportunity for the potential uptake of these blood-borne bacteria by a variety of arthropod vectors that feed on animals and people. five bartonella species are transmitted by lice, fleas or sandflie ...200818380649
domain annotation of trimeric autotransporter adhesins--dataa.trimeric autotransporter adhesins (taas), such as yersinia yada, neisseria nada, moraxella uspas, haemophilus hia and bartonella bada, are important pathogenicity factors of proteobacteria. their high sequence diversity and distinct mosaic-like structure lead to difficulties in the annotation of their sequences. these stem from the large number of short repeats, the presence of compositionally unusual coiled-coils, fuzzy domain boundaries and regions of seemingly low sequence complexity.200818397894
bartonella spp. infection in rodents from different habitats in the mazury lake district, northeast poland.four rodent species (clethrionomys glareolus, apodemus flavicollis, microtus arvalis, m. oeconomus) were captured in the period 2004-2006 in the mazury lake district, northeast poland, to determine the prevalence and genetic diversity of bartonella species. the presence of bartonellae was assessed using polymerase chain reaction (pcr) with primers cs140f and bhcs1137n, amplifying a fragment of the glta gene. bartonella dna was detected in 313 (30.6%) of 1024 rodents sampled: in 181 c. glareolus, ...200818399782
bartonella species antibodies and dna in cerebral spinal fluid of cats with central nervous system disease.bartonella species infection is associated with central nervous system (cns) disease in some humans and cats but the diagnosis is difficult to confirm with blood or serum test results. in this retrospective study of 100 client-owned cats, serum and cerebral spinal fluid (csf) were assayed for bartonella species igg antibodies and csf was assayed for bartonella species dna. bartonella species igg antibodies were detected in serum of 36 cats, bartonella species c-values>1 (suggesting antibody prod ...200818400536
[persistent bartonella infection: epidemiological and clinical implications].bartonella are gram-negative hemotropic bacteria that infect a wide range of mammals. at least 14 bartonella species or subspecies have been reported to be pathogenic for humans and animals. wild and domestic animals represent a large reservoir. reservoir species usually display chronic bacteremia. this explains some aspects of the epidemiology of these infections, and especially vector-borne transmission. the molecular mechanisms of persistent infection have clinical consequences both for occas ...200718402163
emerging pathogens: challenges and successes of molecular diagnostics.more than 50 emerging and reemerging pathogens have been identified during the last 40 years. until 1992 when the institute of medicine issued a report that defined emerging infectious diseases, medicine had been complacent about such infectious diseases despite the alarm bells of infections with human immunodeficiency virus. molecular tools have proven useful in discovering and characterizing emerging viruses and bacteria such as sin nombre virus (hantaviral pulmonary syndrome), hepatitis c vir ...200818403608
visceral involvement in an immunocompetent male: a rare presentation of cat scratch disease.we report a case of an adult, immunocompetent male with lymphadenopathy of both groins, para-aortal lymph nodes and multiple lesions in the spleen. a neoplasm was excluded by histology of the largest lymph node from the left groin. the diagnosis of cat-scratch disease (csd ) became apparent when serological testing for bartonella henselae showed to be positive. a review of literature shows that disseminated (visceral) infection is a rare presentation of csd.200818424863
bartonella quintana and bartonella pediococcus infection after aortic valve replacement.bartonella quintana and bartonella pediococcus infections are very rare causes of endocarditis. urban trench fever with relapsing febrile illness, headache, leg pain, and endocarditis has now begun to be a more important cause of disease in socially disadvantaged persons. the diagnosis is difficult because the growth of b. quintana in blood culture takes 20-40 days. b. pediococcus may be an opportunistic pathogen in severely compromised hosts, although it has been described as a harmless bacteri ...200818430664
beyond cat scratch disease: widening spectrum of bartonella henselae infection.bartonella henselae was discovered a quarter of a century ago as the causative agent of cat scratch disease, a clinical entity described in the literature for more than half a century. as diagnostic techniques improve, our knowledge of the spectrum of clinical disease resulting from infection with bartonella is expanding. this review summarizes current knowledge regarding the microbiology, clinical manifestations, diagnostic techniques, and treatment of b. henselae infection.200818443019
[bartonella henselae and its infections].in recent years the number of identified bartonella species has increased rapidly and several species in bartonella genus isolated from various mammalian reservoirs were recognized as zoonotic agents in humans. three bartonella species are considered to be pathogenic for humans; b. henselae, b. quintana and b. bacilliformis. b. henselae causes asymptomatic intraerythrocytic bacteraemia in the feline reservoir host and is the most important zoonotic species as the cause of human diseases includin ...200818444576
seroprevalence of bartonella spp. infection in hiv patients in catalonia, spain.although the first clinical descriptions of bartonella infection were associated with immunocompromised patient with bacillary angiomatosis, we currently know that this organism is directly involved in diseases affecting a large number of patients, regardless of their immune status. cat scratch disease, hepatic peliosis, and some cases of bacteraemia and endocarditis, are directly caused by some species of the genus bartonella. the purpose of this study was to determinate the prevalence of igg a ...200818452613
severe occlusive vasculitis as a complication of cat scratch disease.the purpose of this communication is to report a severe occlusive vasculitis as a complication of cat scratch.200818454406
molecular detection of bartonella schoenbuchensis from ectoparasites of deer in massachusetts.deer keds (lipoptena cervi) are thought to have been introduced into new england from europe during the 1800 s. we sought to determine whether l. cervi from massachusetts deer contained evidence of infection by bartonella schoenbuchensis, which appears to be maintained by l. cervi in europe. five of 6 keds were found to contain b. schoenbuchensis dna, and 2 deer ticks cofeeding on deer with such keds did as well. the detection of bartonella dna in deer ticks probably represents contamination by ...200818454595
culture-negative infectious endocarditis caused by bartonella spp.: 2 case reports and a review of the literature.bartonella spp. are rare pathogens in humans and were recently recognized as important causative agents of culture-negative endocarditis. here, we describe the 1st 2 documented cases of culture-negative endocarditis due to bartonella henselae and bartonella quintana encountered in a single hospital in germany. infection of the heart valve tissue was detected by broad-range polymerase chain reaction (pcr) and further confirmed by serologic testing. in particular, acute b. henselae infection with ...200818455348
macular hole following bartonella henselae neuroretinitis.to report a case of macular hole secondary to bartonella henselae neuroretinitis.200818465733
bartonella-associated meningoradiculoneuritis and dermatitis or panniculitis in 3 dogs. 200818466250
[cat scratch disease]. 200818470500
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