| the complete nucleotide sequence of the pasteurella multocida toxin gene and evidence for a transcriptional repressor, txar. | the osteolytic toxin of pasteurella multocida induces bone resorption in vivo and in vitro (foged et al., 1988; kimman et al., 1987). in this report the toxin-encoding toxa gene is sequenced, and the deduced primary structure of the toxin shows a protein of 1285 amino acids, containing a striking homology to a metal-binding motif. evidence that expression of the toxa gene is repressed at a transcriptional level in escherichia coli is presented. repression could be abolished either by deletion of ... | 1990 | 2201870 |
| risk assessment of carcinogenic and noncarcinogenic chemicals. | "risk assessment" is a general term used with increasing frequency by both scientists and regulators. scientifically based risk assessments consider available toxicologic data when judging which agents pose a significant risk to the human population. the science of toxicology focuses on identifying potential hazards to human health using surrogate animal studies. margins of safety and establishment of adis (acceptable daily intakes) are methods applied to animal test data to set "safe" levels of ... | 1990 | 2202326 |
| specificity of dna probes for the detection of toxigenic pasteurella multocida subsp. multocida strains. | five dna probes directed against different regions of the gene that encodes the dermonecrotic toxin of pasteurella multocida subsp. multocida were examined for their ability to identify toxigenic p. multocida subsp. multocida strains. the specificities of the probes were studied with 96 strains of p. multocida subsp. multocida and 22 strains of 11 other bacterial species. results of colony hybridization assays using these probes indicated that two of the five probes have potential diagnostic val ... | 1990 | 2203816 |
| bovine recombinant granulocyte-macrophage colony-stimulating factor enhancement of bovine neutrophil functions in vitro. | neutrophils were purified from blood of dexamethasone-treated (0.04 mg/kg of body weight) and untreated calves. cells were untreated (controls) or cultured in media containing 5 or 10 ng of bovine recombinant granulocyte-macrophage colony-stimulating factor (rbgm-csf)/ml for 10 to 12 hours before being tested for various functions. dexamethasone treatment of calves decreased luminol-dependent chemiluminescence, decreased phagocytosis of pasteurella multocida and several staphylococcus spp by var ... | 1990 | 2204299 |
| a case of unexpected pasteurella multocida bacteremia. | a case of pasteurella multocida bacteremia in a previously healthy hospital employee is presented. the patient had sustained a scratch from his dog four days prior to being seen in the emergency department with adequate healing and no evidence of localized infection. he presented with an acute febrile illness, and was discharged from the emergency department with a diagnosis of viral syndrome. he was asked to return to the hospital the next day when a bacteriology report of gram negative rods in ... | 1990 | 2212562 |
| [epizootiology, clinical aspects and therapy of pasteurella multocida infection in bird patients after cat bite]. | since early 1986, fatal cases of pasteurella multocida infection following cat bites have been seen regularly among avian patients at our institute. the problems of the epizootiology of this infection are discussed on the basis of research during the last three and a half years. by evaluation of collected data from clinical examinations, autopsies, bacteriological and biochemical diagnosis of isolated strains from birds and cats the possibility of transmission via cat bite is discussed as well a ... | 1990 | 2219107 |
| bactericidal activity in the sera of mice vaccinated with pasteurella multocida type a. | the susceptibility of pasteurella multocida to killing by serum and the ability of protective vaccines to stimulate this mechanism of immunity in mice were investigated. p. multocida type of bovine origin was used to prepare a vaccine incorporating heat killed organisms and for homologous infection of mice. bactericidal capacity and elisa antibody titres were determined for individual mouse sera. protection was clearly associated with bactericidal antibodies raised by vaccination. the bactericid ... | 1990 | 2219665 |
| [electron microscopic studies of mucosal extirpates of rabbits after after in vitro contact with pasteurella multocida subsp. multocida strains]. | in vitro experiments of adhesion and colonisation of mucosal surface fragments (nose, trachea) from freshly killed rabbits with four strains of pasteurella multocida subsp. multocida with different types of capsule antigen (a, d, without capsule) showed the following results: above all the capsule serovar a strain, producing a capsule of hyaluronic acid and fimbria, were able to adhere and to form microcolonies on the mucosal surface. microvilli of epithelial cells and mucus producing cells were ... | 1990 | 2220185 |
| acute dacryocystitis caused by pasteurella multocida. | | 1990 | 2220992 |
| chloroplast glyceraldehyde-3-phosphate dehydrogenase (nadp): amino acid sequence of the subunits from isoenzyme i and structural relationship with isoenzyme ii. | the structural relationship between isoenzymes i and ii of chloroplast glyceraldehyde-3-phosphate dehydrogenase (d-glyceraldehyde-3-phosphate: nadp+ oxidoreductase (phosphorylating) ec 1.2.1.13) has been established at the protein level. the complete primary structure of subunits a and b of glyceraldehyde-3-phosphate dehydrogenase i from spinacia oleracea has been determined by sequence analysis of the corresponding tryptic peptides, aligned by fragments derived from cyanogen bromide and staphyl ... | 1990 | 2223845 |
| abelson murine leukemia virus transforms preneoplastic emu-myc transgene-carrying cells of the b-lymphocyte lineage into plasmablastic tumors. | e mu-myc transgenic mice were back-crossed to balb/c mice up to back-cross generation 3. the offspring that included transgene-carrying and -negative mice in approximately equal proportions were randomly divided into 2 groups. thirty-four mice (group i) were treated with pristane, followed by a-mulv, and 40 (group ii) were injected with a-mulv alone. altogether, 16 lymphoid tumors developed in group i and 17 in group ii. nine of the tumors in group i and 4 in group ii appeared as ascitic tumors. ... | 1990 | 2228313 |
| [a case of pasteurella multocida infection in bronchiectasis]. | pasteurella multocide (p. multocida), a small gram-negative bacillus, has been known to be the causative agent of hemorrhagic septicemia in animals. p. multocida infection in human was reported as skin abscess and/or septicemia after an animal bit or scratch. pulmonary infections of p. multocida have been developed in the patients with chronic pulmonary diseases such as bronchiectasis. in japan, however, p. multocida respiratory tract infections are rare. in this report, a 80-year-old female wit ... | 1990 | 2230375 |
| [the capacity for regeneration of the myocardium in rat fetuses]. | a reproducible model of heart injury in 16-days old rat fetuses has been developed. 30 days after the injury a 4-fold increase of the damaged area was observed. decrease of reparative capacity of myocardium in fetuses as compared with the adults is due to the functional immaturity of the connective tissue cells. | 1990 | 2234794 |
| influence of dietary supplementation with streptococcus faecium m-74 on broiler body weight, feed conversion, carcass characteristics, and intestinal microbial colonization. | two experiments were conducted to determine the influence of streptococcus faecium m-74 supplementation of broiler diets. mixed-sex or male only chicks were used in the experiments. both experiments consisted of six dietary treatments and four replicates per treatment in a randomized block design. the s. faecium was fed alone for 21, 36, or 44 days or for 44 days with s. faecium supplemented in the water for the first 14 days. in another treatment, s. faecium was fed for 44 days, but the feed wa ... | 1990 | 2235841 |
| evaluation of bcg at birth in the united arab emirates. | a total of 387 healthy full term infants who received bcg vaccination at birth were evaluated by the tuberculin ppd test at 6-8 weeks post vaccination. a total of 92% of these infants had visible bcg scars at that time. all infants were tested with ppd but only 264 returned for the test to be read. the tuberculin test was negative in 37 (14%) and of less than 5 mm induration in another 60 (23%) of the infants. the same pattern was observed in different nationalities. of 11 infants with no bcg sc ... | 1990 | 2238123 |
| evaluation of bcg at birth in the united arab emirates. | a total of 387 healthy full term infants who received bcg vaccination at birth were evaluated by the tuberculin ppd test at 6-8 weeks post vaccination. a total of 92% of these infants had visible bcg scars at that time. all infants were tested with ppd but only 264 returned for the test to be read. the tuberculin test was negative in 37 (14%) and of less than 5 mm induration in another 60 (23%) of the infants. the same pattern was observed in different nationalities. of 11 infants with no bcg sc ... | 1990 | 2238123 |
| [selective screening for hypercholesterolemia. results from a screening model in general practice]. | at present, it appears to be probable that both dietary changes and medicinal treatment can reduce the risk of development of coronary disease in middle-aged men with moderately to severely raised blood cholesterol values. internationally, the limits for cholesterol intervention are considerably lower than in denmark. extensive cholesterol screening is, however, very expensive and the identified persons with high cholesterol values will frequently be found in sex and age groups where the benefic ... | 1990 | 2238223 |
| [selective screening for hypercholesterolemia. results from a screening model in general practice]. | at present, it appears to be probable that both dietary changes and medicinal treatment can reduce the risk of development of coronary disease in middle-aged men with moderately to severely raised blood cholesterol values. internationally, the limits for cholesterol intervention are considerably lower than in denmark. extensive cholesterol screening is, however, very expensive and the identified persons with high cholesterol values will frequently be found in sex and age groups where the benefic ... | 1990 | 2238223 |
| [effect of enalapril on heart rate, arterial blood pressure and exocrine pancreatic secretion in the alert dog]. | a changed exocrine pancreatic secretion could be a pathogenetic factor of an acute pancreatitis after administration of angiotensin-converting enzyme (ace) inhibitors. in six conscious dogs with gastric and duodenal thomas fistulas we studied the effect of an intravenous (iv.) bolus injection of 10 mg enalaprilat, an intraduodenal (id.) bolus injection of 20 and 40 mg enalapril (e.), and 0.15 m nacl (20 ml iv., resp., id.) on pancreatic bicarbonate- and protein output in response to secretin (20 ... | 1990 | 2238764 |
| erythromycin failure with subsequent pasteurella multocida meningitis and septic arthritis in a cat-bite victim. | we report the case of a 75-year-old woman who developed pasteurella multocida meningitis and septic arthritis while being treated for a cat-bite wound infection with erythromycin. review of the literature revealed that erythromycin has poor in vitro activity against this bacterium and has been associated with serious clinical failures. we recommend that erythromycin not be prescribed for empiric therapy of established animal-bite infections. suggestions for optimal empiric therapy of animal-bite ... | 1990 | 2240761 |
| in vitro susceptibility of some porcine respiratory tract pathogens to aditoprim, trimethoprim, sulfadimethoxine, sulfamethoxazole, and combinations of these agents. | the in vitro antimicrobial activities of aditoprim (ap), a new dihydrofolate reductase (dhfr) inhibitor, trimethoprim (tmp), sulfadimethoxine (sdm), sulfamethoxazole (smx), and combinations of these drugs against some porcine respiratory tract pathogens were determined by use of an agar dilution method. the minimal inhibitory concentrations (mic) of these agents were determined twice against bordetella bronchiseptica (n = 10), pasteurella multocida (n = 10), and actinobacillus pleuropneumoniae ( ... | 1990 | 2240813 |
| comparison of enzyme-linked immunosorbent assay with dot immunobinding assay for detection of antibodies against pasteurella multocida in turkeys. | a dot immunobinding assay (dia) was developed to detect antibodies against pasteurella multocida in turkey serum. five coating antigens, namely, whole-cell (wc) antigen, sonicated cell lysate (scl), crude capsular extract (ce), formalin extract (fe), and heat-stable antigen (hsa), were compared by enzyme-linked immunosorbent assay (elisa) and dia using reference antisera against p. multocida organisms. wc and scl antigens showed higher sensitivity, whereas fe and hsa antigens were more specific ... | 1990 | 2241679 |
| [atrophic rhinitis in swine and other animal species]. | evidence that cattle, goats and rabbits may suffer from natural diseases equivalent to porcine atrophic rhinitis is presented. etiology and course of the progressive (enzootic) and non-progressive (sporadic) forms of atrophic rhinitis in pigs are discussed and compared with known data about similar diseases in other animals. it seems that atrophic rhinitis caused by toxigenic strains of pasteurella multocida may be a disease of different animal species. | 1990 | 2242733 |
| determination of an antigen suitable for enzyme-linked immunosorbent assay of the antibody to bordetella bronchiseptica in guinea pigs. | to establish an enzyme-linked immunosorbent assay (elisa) technique for the serological diagnosis of infections caused by bordetella bronchiseptica (b. bronchiseptica) in guinea pigs, the authors recently assessed the usefulness of three antigen preparations derived from the bacterial cell components: sonication antigen (s-ag), cell surface antigen (c-ag) and lipopolysaccharide antigen (l-ag). the use of s-ag for elisa resulted in the most sensitive detection of the antibody to b. bronchiseptica ... | 1990 | 2242767 |
| [human respiratory tract infection by pasteurella multocida subsp. multocida presumably derived from the cat]. | pasteurella multocida is a gram-negative short rod-shaped bacteria that has been recognized as a pathogen of hemorrhagic septicemia and fowl cholera in the veterinary medicine. infections by this microorganism as seen in the foreign literature vary widely from local infections due to bites and scratches by animals to general infections such as infections of the respiratory tract, sepsis, and meningitis. in japan, reported cases of p. multocida infections are predominantly local infections, follo ... | 1990 | 2243191 |
| phenotypical and genotypical characteristics of paired isolates of pasteurella multocida from the lungs and kidneys of slaughtered pigs. | twenty-eight strains of pasteurella multocida were isolated from 12 danish and two canadian abattoir pigs. fourteen strains were isolated from pulmonary inflammatory lesions, and 14 strains were isolated from kidneys of the same animals. phenotypical and genotypical characteristics of the strains were evaluated with a view to determine if p. multocida isolated from kidneys might have been disseminated from the lungs. all field strains were capsular type a. the biochemical reactivity in the api-2 ... | 1990 | 2247937 |
| [the absorption of colostral immunoglobulins in newborn piglets. i. effect of time from birth to the first feeding]. | the effects of a delayed onset of feeding on the absorption of intact immunoglobulins from the small intestines was investigated in newborn piglets by using an automatic device ("artificial sow"). fasting periods extended to a maximum of 24 hours and were followed by 12 hourly allotments of 25 ml of sow colostrum. the concentrations of immunoglobulins g, a and m were analyzed in plasma samples drawn before and after the onset of feeding. the capacity for ig-absorption was not impaired by the fas ... | 1990 | 2248612 |
| [the absorption of colostral immunoglobulins in newborn piglets. i. effect of time from birth to the first feeding]. | the effects of a delayed onset of feeding on the absorption of intact immunoglobulins from the small intestines was investigated in newborn piglets by using an automatic device ("artificial sow"). fasting periods extended to a maximum of 24 hours and were followed by 12 hourly allotments of 25 ml of sow colostrum. the concentrations of immunoglobulins g, a and m were analyzed in plasma samples drawn before and after the onset of feeding. the capacity for ig-absorption was not impaired by the fas ... | 1990 | 2248612 |
| restriction endonuclease analysis of porcine pasteurella multocida isolates from quebec. | we have used restriction endonuclease analysis (rea) of genomic dna to classify porcine pasteurella multocida isolates with similar capsular and somatic serotypes, and to monitor the distribution of isolates from 12 different herds in quebec. within herds, p. multocida isolates of similar capsular and somatic serotypes showed similar rea fingerprints. between herds, some isolates had similar rea fingerprints. however, differences in rea enabled subtyping of many p. multocida isolates with the sa ... | 1990 | 2249176 |
| evaluation of numerical typing systems for escherichia coli using the api 50 ch and the php-ec systems as models. | reproducible and discriminating typing methods are required for epidemiological investigations. numerical typing systems analyse patterns obtained in various ways by calculating similarity coefficients between isolates. in the present study, various measures of the efficiency of a numerical typing system are quantified. these include reproducibility, accuracy, and discrimination power. three different numerical typing methods for escherichia coli were compared using these measures: (a) biotyping ... | 1990 | 2249716 |
| a survey of infectious diseases in wild turkeys (meleagridis gallopavo silvestris) from arkansas. | wild turkeys (meleagridis gallopavo silvestris) trapped as part of a relocation program by the arkansas game and fish commission were tested for selected infectious diseases and parasites. the 45 birds were trapped at four locations in pope, scott, and montgomery counties (arkansas, usa). forty-four blood samples for serology, 27 blood smears and 12 fecal samples were collected. of the serum samples tested, 20 of 44 (45%) were positive for pasteurella multocida by enzyme-linked immunosorbent ass ... | 1990 | 2250323 |
| [influenza]. | | 1990 | 2258671 |
| production of mouse monoclonal antibodies to pasteurella multocida type a and the immunological properties of a protective anti-lipopolysaccharide antibody. | eight monoclonal antibodies (mabs) were produced from mice immunised with whole cells of heat-killed pasteurella multocida type a which had been cultured under iron-restricted conditions. the mabs were selected by an enzyme-linked immunosorbent assay (elisa) in which the antigen consisted of whole bacteria of the immunising strain. their reactivity was investigated further by immunoblotting, indirect haemagglutination, a complement-mediated bactericidal assay and passive protection of mice. one ... | 1990 | 2258910 |
| effects of purified pasteurella multocida dermonecrotoxin on cartilage and bone of the nasal ventral conchae of the piglet. | the effect of intramuscular injection of purified dermonecrotoxin (dnt) from pasteurella multocida type d on the nasal ventral conchae of piglets was studied. severe atrophy of the conchae was observed 4, 6, and 10 days after injection (p.i.d). lesions were observed in conchae cartilage and bone. cartilage changes observed were the absence of chondrocyte maturation and hypertrophy, hyaline cartilage invasion by fibroblast-like and multinucleated cells, and endothelium damage with haemorrhages al ... | 1990 | 2260779 |
| a model to study physiological activation of phospholipase a2 and vasorelaxation by lysophosphatidylcholine. | earlier we demonstrated that micellar solutions of lpc caused endothelium-dependent relaxation of rabbit thoracic aorta and bovine intrapulmonary artery and vein through a cyclic gmp-dependent mechanism. the availability of lpc for vasorelaxation depends on its production by deacylation of pc by pla2. we assessed the possible activation of pla2 by commonly used vasorelaxants such as acetylcholine, bradykinin, calcium ionophore a23187 and thrombin and vasoconstrictors like histamine and phenyleph ... | 1990 | 2266777 |
| pneumocystis carinii pneumonia in danish piglets. | | 1990 | 2267715 |
| sequence analysis of the potent mitogenic toxin of pasteurella multocida. | pasteurella multocida toxin is a potent mitogen for cultured swiss 3t3 cells where it causes an accumulation of inositol phosphates and activation of protein kinase c. the gene sequence described here coded for a 146 kda protein. the orf was preceded by a ribosome binding site and followed by a stem loop. there was no evidence for a signal sequence. the gene had a low g + c base ratio which differs from the rest of the pasteurella genome. there was no significant homology with other known protei ... | 1990 | 2269370 |
| in vivo activity of orally administered antibiotics and chemotherapeutics against acute septicaemic pasteurellosis in rabbits. | different antibiotics and chemotherapeutics were tested for therapeutic efficacy in rabbits, in an experimental model using a pasteurella multocida strain which causes hyperacute septicaemia in this animal species. only enrofloxacin, administered in the drinking water at a concentration of 50-100 mg/l cured the rabbits, provided that a daily intake of 5 mg/kg body weight was achieved. the other drugs tested (tetracycline, spiramycin, erythromycin and a combination of sulfamerazine with trimethop ... | 1990 | 2270044 |
| bone allografts sterilised by irradiation. biological properties, procurement and results of 150 massive allografts. | massive bone allografts from cadavers have been sterilised by gamma-radiation from radioactive cobalt at a dose of 25,000 gray (gy). the biological effects of radiation are discussed. human cortical bone showed an acceptable 20% decrease in strength on bending tests after 27,000 gy irradiation, but higher doses are more damaging and should be avoided. the procurement protocol used at the cochin hospital is described, and the importance of dosimetry and record-keeping emphasised. the clinical res ... | 1990 | 2279829 |
| prevalence and characterization of pasteurella multocida in rabbits and their environment in japan. | prevalence and some properties of pasteurella multocida in rabbits kept at laboratory animal facilities and commercial rabbitries, and in their environment were investigated. a total of 1,147 nasal swab samples from 1,147 rabbits and 126 samples from their environment were subjected to the isolation of p. multocida. the bacteria were isolated from 199 (29.8%) of 668 rabbits in laboratory animal facilities and from 1 (0.2%) of 479 rabbits in the rabbitries. isolation rate of p. multocida was low ... | 1990 | 2280501 |
| serum resistance as an indicator of virulence of pasteurella multocida for turkeys. | wildlife isolates of pasteurella multocida, whose virulence for turkeys had previously been determined by intravenous inoculation, were characterized regarding their ability to survive incubation in fresh non-immune turkey serum. the relative virulence of the isolates was significantly associated with their ability to resist the bactericidal power of the serum as determined by standard plate counts following incubation. organisms with a high survival value were more virulent; those with a low su ... | 1990 | 2282018 |
| fowl cholera in california multiplier breeder turkeys: 1985-86. | one hundred twenty-nine multiplier breeder turkey flocks on 45 premises in california were monitored for outbreaks of fowl cholera (fc) (pasteurella multocida) for 1 year (aug. 1, 1985, through july 31, 1986). fourteen (11%) flocks on 10 (22%) premises experienced outbreaks. nine (64%) outbreaks occurred in the fall or winter. fc-outbreak flocks had significantly shorter lay cycles (24.6 weeks vs. 27.9 weeks) and correspondingly lower total egg production per hen (84 eggs vs. 103 eggs) than non- ... | 1990 | 2282022 |
| drug resistance and r plasmids in pasteurella multocida isolates from swine. | a total of 163 strains of pasteurella multocida isolated from swine were examined for drug resistance and r plasmids. strains resistant to sulfadimethoxine (sar), ampicillin (apr), streptomycin (smr), kanamycin (kmr), and chloramphenicol (cpr) were found in 93.9, 1.8, 16.6, 1.2, and 10.4%, respectively. there were two patterns of drug resistance (sar and sarcpr) in isolates from nasal cavities, and five patterns (sar, sarsmr, sarsmrcpr, sarsmrapr, and sarsmrkmrcpr) in isolates from pneumonic lun ... | 1990 | 2283954 |
| serotypes of pasteurella multocida isolates from rabbits and their environment in japan. | | 1990 | 2287134 |
| overberg research project. ix. first stage larvae per gram [l1p.g.] of faeces; an efficient method of diagnosing nematode parasites of sheep ante mortem. | nematode eggs were collected by mixing the faeces with a sugar solution, filling a flat-sided medicine bottle (100 ml), and allowing eggs to float and adhere to the upper surface for 30 min. after discarding the faeces, eggs hatched within 24 h at 20-30 degrees c. each genus was counted in a counting chamber and the l1p.g. estimated. the morphology of l1 of haemonchus, teladorsagia, trichostrongylus, oesophagostomum and strongyloides is briefly described. | 1990 | 2293137 |
| development and epidemiological applications of a bacteriophage typing system for typing pasteurella multocida. | a bacteriophage typing system was developed for typing toxigenic and nontoxigenic strains of pasteurella multocida. a phage set of 24 phages with different lytic spectra was isolated after mitomycin treatment of p. multocida strains, isolated mainly from pigs from herds with atrophic rhinitis. on a test set of 97 different strains isolated from pigs, these 24 phages were able to type 87% of the strains. the 97 test strains could be subdivided into 31 different types by reaction with the 24 phage ... | 1990 | 2298868 |
| pasteurella multocida and bordetella bronchiseptica infections in rabbits. | the natural history of infection with pasteurella multocida and bordetella bronchiseptica in domestic rabbits was studied prospectively at a commercial rabbitry. at weaning, about 25% of rabbits had nasal infections with p. multocida and 75% had infections with b. bronchiseptica. infection of weanling rabbits paralleled nasal infections of their dams. the proportion of rabbits with both infections increased with age. at 2 to 4 months old, about 50% of rabbits with p. multocida or p. multocida an ... | 1990 | 2298879 |
| pasteurella multocida empyema: successful treatment with open thoracostomy. | pasteurella multocida appears to be an uncommon pathogen in human thoracic empyema. the morbidity and mortality associated with these infections has been significant, presumably secondary to the elderly populations they affect, many with chronic lung disease and impaired pulmonary defenses. we report a case of pasteurella empyema treated with open thoracostomy and rib resection and advocate use of such a procedure early in the treatment of patients with this infection. | 1990 | 2299250 |
| soft-tissue pasteurella multocida infection caused by a fish bone puncture. | | 1990 | 2303068 |
| host response to pasteurella multocida turbinate atrophy toxin in swine. | a porcine strain of pasteurella multocida (serotype d:3) produced a toxin causing turbinate atrophy (ta) in pigs. the toxin (tat), processed on a high performance liquid chromatography size exclusion column, eluted as a single peak (molecular weight of about 160,000) containing trace amounts of endotoxin (lipopolysaccharide, lps; protein:lps, 85:1). the eluted fraction migrated on sodium dodecyl sulfate polyacrylamide gels as a single band. it could be prevented from dissociating into two promin ... | 1990 | 2306667 |
| streptococcus suis infection in swine. a sixteen month study. | a total of 349 isolates of streptococcus suis retrieved from different tissues from diseased pigs were examined in this study. only 48% of them could be categorized as one of serotypes 1 to 8 and 1/2. among typable isolates, serotype 2 was the most prevalent (23%), followed by serotype 3 (10%). the majority of all isolates originated from lungs, meninges/brain, and multiple tissues. forty-one percent of typable isolates and 33% of untypable isolates were retrieved in pure culture. other isolates ... | 1990 | 2306668 |
| in vitro susceptibility of selected veterinary bacterial pathogens to ciprofloxacin, enrofloxacin and norfloxacin. | the minimum inhibitory concentrations (mic) of ciprofloxacin, enrofloxacin, and norfloxacin were tested for approximately ten clinical isolates of each of actinobacillus pleuropneumoniae, actinobacillus suis, actinomyces pyogenes, corynebacterium pseudotuberculosis, erysipelothrix rhusiopathiae, haemophilus parasuis, haemophilus somnus, pasteurella haemolytica, pasteurella multocida, rhodococcus equi, streptococcus equi, streptococcus suis and streptococcus zooepidemicus. ciprofloxacin and enrof ... | 1990 | 2306672 |
| somnogenic, pyrogenic, and hematologic effects of experimental pasteurellosis in rabbits. | previous work has demonstrated that intravenous inoculation of rabbits with various microorganisms induces complex time-dependent alterations in sleep as well as other pathophysiological effects typically associated with infectious disease. to evaluate the effects of bacterial challenge that more closely resembles naturally developing disease, we inoculated rabbits with pasteurella multocida, a common pathogen of this species, using routes of administration that mimic normal routes of exposure. ... | 1990 | 2309940 |
| turkey heterophil chemotaxis to pasteurella multocida (serotype 3,4)-generated chemotactic factors. | the purpose of this study was to determine the ability of three strains or isolates of pasteurella multocida (serotype 3,4) to generate chemotactic factors for heterophils when exposed to pooled turkey serum. results indicated that each bacterial strain or isolate (m-9, cu, and 86-1913) was associated with the production of chemotactic factors, but the more pathogenic bacterial isolate (86-1913) elicited greater heterophil migration in chemotaxis studies. | 1990 | 2322223 |
| somatic serotypes of pasteurella multocida strains isolated from avian hosts (1976-1988). | during the period of 1976-88, 733 strains of pasteurella multocida isolated from avian hosts were submitted to the national animal disease center for somatic serotyping. the serotypes were determined and are presented in a summarized form in this report. the most common serotypes were 3 (29%); 1 (18%); 3,4 (12%); and 3,4,12 (9%). the 733 strains had been isolated from 25 species of avian hosts; 400 (55%) were from turkeys. the most common serotypes of strains from turkeys were 3 (38%); 3,4 (18%) ... | 1990 | 2322224 |
| alternative injection sites for a pasteurella multocida bacterin. | seven different injection sites for a pasteurella multocida bacterin were evaluated by measuring the immune response and the local tissue reaction. injection into the ventral surface of the tail or subcutaneously along the dorsal midline of the neck were the most suitable procedures. ease of application was judged subjectively, and the tail site was found to be easier to inject accurately than the subcutaneous neck site. the tail injection site was found to be the best overall when immune respon ... | 1990 | 2322226 |
| long-term clearance of inhaled uo2 particles from the pulmonary region of the rat. | this paper reports on an enriched uranium dioxide (uo2) mass clearance study undertaken with fischer-344 rats. the uo2 had a uranium (u) isotopic composition of 0.79% 234u, 92.8% 235u, 0.34% 236u and 6.06% 238u, by mass, with an alpha-particle activity of 1.91 bq micrograms-1. forty-six rats were exposed to an enriched uo2 aerosol that had an activity median particle aerodynamic diameter ranging from 2.7 to 3.2 microns. the rats were killed from 1 to 720 d post-inhalation (pi). the mass of enric ... | 1990 | 2323929 |
| novel antibiotics, furaquinocins a and b. taxonomy, fermentation, isolation and physico-chemical and biological characteristics. | two novel antibiotics, furaquinocins a and b were isolated from the culture broth of streptomyces sp. ko-3988. these antibiotics possess cytocidal activities against hela s3 cells in vitro at concentrations of 3.1 micrograms/ml for a and 1.6 micrograms/ml for b. neither substance possessed antimicrobial activities against gram-positive and gram-negative bacteria, fungi or yeast at a concentration of 1,000 micrograms/ml. | 1990 | 2324009 |
| cloning and expression of the dermonecrotic toxin gene of pasteurella multocida ssp. multocida in escherichia coli. | a dna library of pasteurella multocida ssp. multocida strain cvi 47459 was constructed in the lambda gem-11 vector. recombinant clones that encoded dermonecrotic toxin (dnt) were identified immunologically with antiserum raised against purified dnt. by comparing the dna restriction maps of the immunoreactive recombinants, we located the dnt gene. hybridization studies with 10 strains of p. multocida ssp. multocida suggested that strains that do not produce the dnt do not contain sequences homolo ... | 1990 | 2328908 |
| comparisons of pasteurella multocida lipopolysaccharides by sodium dodecyl sulfate-polyacrylamide gel electrophoresis to determine relationship between group b and e hemorrhagic septicemia strains and serologically related group a strains. | lipopolysaccharides (lpss) purified from 16 reference somatic serotypes of pasteurella multocida were examined and compared by discontinuous sodium dodecyl sulfate-polyacrylamide gel electrophoresis. resolution of lps patterns in a gel was optimum when sample wells were cast separately from the stacking gel and the running gel consisted of 15% t (total monomer) polyacrylamide and 4 m deionized urea. band patterns of p. multocida lpss in a gel differed from control salmonella minnesota wild-type ... | 1990 | 2332462 |
| effects of sewage sludge on the immune defenses of mallards. | sewage sludge contains numerous chemicals that, if ingested, could affect the immunological status of wild birds and, in particular, their resistance to infectious disease. mallard ducks were fed a diet containing 0, 5, or 20% dried sewage sludge from either milwaukee or madison, wisconsin, for 28 and 57 days, respectively. when subsequently challenged with pasteurella multocida, the mortality in the sludge-treated groups was no greater than that in the untreated control groups. there was, howev ... | 1990 | 2335161 |
| characteristics of pasteurella multocida isolated from waterfowl and associated avian species in california. | characteristics of pasteurella multocida isolated from tissues of dead waterfowl and associated avian species found at 23 sites located in northern and central california, from january 1986 through january 1988 are reported. two hundred ninety five isolates of p. multocida were obtained from 23 avian species. most of the isolates belonged to the subspecies p. multocida multocida (63%), followed by p. multocida gallicida (37%), and by p. multocida septica (less than 1%). there appeared to be a hi ... | 1990 | 2338724 |
| pasteurella multocida infections in rockhopper penguins (eudyptes chrysocome) from campbell island, new zealand. | during an investigation into the population decline of rockhopper penguins (eudyptes chrysocome) on campbell island, new zealand, avian cholera (pasteurella multocida) was found in dead adults and chicks. an rna enveloped virus was isolated from ixodes uriae, a tick which commonly parasitizes rockhopper penguins on the island. it is not known whether this virus is virulent for penguins. no evidence was obtained to suggest that avian cholera was the principal cause for the decline in the rockhopp ... | 1990 | 2338734 |
| sequence of the dermonecrotic toxin of pasteurella multocida ssp. multocida. | | 1990 | 2339066 |
| outer membrane proteins of bovine strains of pasteurella multocida type a and their doubtful role as protective antigens. | outer membranes were prepared by the sarkosyl method from 30 strains of pasteurella multocida and the closely related taxon 13, which had been isolated from cattle. the patterns of the outer membrane proteins (omps) on sds-page were generally similar to one another, though the four major proteins (a-d) varied somewhat in molecular mass; these patterns allowed the strains to be arranged into 12 groups. taxon 13 strains and typical p. multocida strains were indistinguishable, both types being foun ... | 1990 | 2342087 |
| [bactericides against pasteurella multocida in whole blood, plasma and lung lavage fluid of untreated and immunized young swine and calves]. | the investigation of bactericidal effects in the whole blood and plasma of young pigs and calves against pasteurella multocida has shown that such effects only come into being or are activated during the direct interaction between the host and pasteurellae, with effects being increased in previously immunized animals. the same is true for the antibodies which are detectable by indirect haemagglutination. there is no bactericidal effect in the concentrated lung lavage fluid against pasteurellae. | 1990 | 2344241 |
| chlamydia trachomatis--role in tubal infertility. | the prevalence of humoural igg and igm antibodies to chlamydia trachomatis was determined in 110 infertile women and compared to 87 healthy pregnant women without any known fertility problem. overall antibodies to chlamydia were detected in 45% of infertile women. antibodies were found in significantly more patients with tubal factor infertility (65%) than in women whose infertility was due to other causes (22%) (p less than 0.005). these findings are consistent with the hypothesis that c. trach ... | 1990 | 2346458 |
| effect of calcium glucarate on beta-glucuronidase activity and glucarate content of certain vegetables and fruits. | glucarate is normally present in tissues and body fluids and is in equilibrium with d-glucaro-1,4-lactone, a natural inhibitor of beta-glucuronidase activity. dietary calcium glucarate, a sustained-release from of glucarate, elevates the blood level of d-glucaro-1,4-lactone which suppresses blood and tissue beta-glucuronidase activity. a single dose of cag (4.5 mmole/kg body weight) inhibited beta-glucuronidase activity in serum and liver, lung, and intestinal microsomes by 57, 44, 37, and 39%, ... | 1990 | 2346674 |
| drug-susceptibility of pasteurella multocida isolated from swine from 1987 to 1989. | | 1990 | 2348600 |
| cloning of the toxin gene from pasteurella multocida and its role in atrophic rhinitis. | the gene for the osteolytic toxin of pasteurella multocida has been cloned into a plasmid vector and expressed off its own promoter in escherichia coli. particular restriction endonucleases failed to cut the gene and regions flanking it, suggesting an a + t base ratio significantly greater than the remaining genome of p. multocida. cloned toxin was indistinguishable from the native toxin with respect to molecular mass, antigenicity and toxicity in different tests. a single intraperitoneal inject ... | 1990 | 2351955 |
| the obligate and facultatively anaerobic bacterial flora of the normal feline gingival margin. | samples from the gingival margins of 14 cats considered normal on clinical examination were cultured for facultative and obligate anaerobic bacteria. all mouths were free from any gingival marginal inflammation and tartar build-up; all cats were between 6 and 12 months of age. a mixed growth was obtained from all samples. the mean number of bacterial species per sample was 10.7 with a range of 7-16 isolates. of the 150 isolates processed, 109 (72.66%) were obligate anaerobes. of the facultativel ... | 1990 | 2353448 |
| septic monarthritis due to pasteurella multocida after a cat scratch in a patient with rheumatoid arthritis. | a 60-yr-old woman with a history of seropositive rheumatoid arthritis and using a low dose of corticosteroids presented with a very painful, swollen, red coloured knee with limited range of motion. physical examination revealed a scratch on her left lower leg without discolouration or induration. synovial fluid cultures yielded pasteurella multocida. the pathogenetic significance of this commensal of cats and dogs in man is discussed. | 1990 | 2355999 |
| detection and distribution of toxigenic pasteurella multocida in pig herds with different degrees of atrophic rhinitis. | four herds of pigs were selected which had different degrees of clinical atrophic rhinitis and used different specific counter-measures. in two of them, the clinical signs occurred spasmodically and were slight. the sows, suckling pigs and growing pigs in all the herds were sampled for toxigenic pasteurella multocida. in one of the slightly affected herds (herd d), the weaners were moved to a second farm for finishing. no toxigenic p multocida were found at the breeding farm, but 50 per cent of ... | 1990 | 2356600 |
| a comparison of different challenge methods for induction of atrophic rhinitis in pigs. | transmission and development of atrophic rhinitis (ar) was studied in 5- to 15-week-old pigs (groups 2-7) originating from a herd free of ar, and compared to unexposed healthy pigs (group 1), and pigs from a herd with endemic ar (group 8). at the start of the trial, pigs in groups 2-5 were challenged intranasally twice a week for 3 weeks with pure cultures of bacteria originating from the endemic ar herd: nontoxigenic pasteurella multocida type a (pma) plus bordetella bronchiseptica phase i (bb) ... | 1990 | 2357344 |
| adherence of bordetella bronchiseptica and pasteurella multocida to swine nasal ciliated epithelial cells in vitro. | a bacterial adherence assay using swine nasal turbinate fragments was established. turbinate fragments were incubated with bordetella bronchiseptica or pasteurella multocida type d at different concentrations or for different incubation times at 37 degrees c on a shaker at 120 rev/min. b. bronchiseptica phase i strains exhibited strong adherence to swine nasal ciliated epithelial cells. the number of adherent bacteria per cell increased when the bacterial concentration or incubation time increas ... | 1990 | 2357345 |
| a model for the induction of pasteurella multocida type-a pneumonia in pigs. | a model for the induction of pneumonia caused by pasteurella multocida type-a was developed. anesthetized pigs were dosed intratracheally with 10(10) colony forming units of p. multocida type-a suspended in a total dose of saline based on the pig's body weight (8 ml/kg). a severe bronchopneumonia was present when the treated pigs were euthanized seven days postinfection. the mean percentage of pneumonic lesions in the treated pigs, as determined by morphometric measurement, was 14.03 +/- 7.01 (x ... | 1990 | 2357661 |
| the pattern of axonal degeneration in the peripheral nervous system varies with different types of lesion. | degeneration of axons in the mouse sciatic nerve was examined using conventional silver staining and by noting the presence or absence of a compound action potential on stimulating the nerve distal to the point of crush or cut. the presence of myeloperoxidase-positive cells was also examined in frozen sections of the nerve. in all experiments the distal, disconnected segment was studied. degeneration after crushing with fine watchmakers forceps always began in the most distal part of the nerve a ... | 1990 | 2359492 |
| immune defence mechanism against blood-borne pasteurella multocida in turkeys. | humoral and cellular immune defence factors involved in controlling blood-borne pasteurella multocida were investigated in turkeys by the passive transfer of immune serum or by the treatment with macrophage-activating agents. the treated and untreated birds were intravenously inoculated with a virulent strain of p multocida, and the viable bacteria in the blood, liver and spleen were counted. in untreated birds, the bacteria were rapidly removed from the blood, and the majority were recovered fr ... | 1990 | 2359884 |
| modulation of the b-a transition of dna by potential antitumor antibiotics. influence of the base composition of dna. | the b-a transition of dna in oriented films of dna-drug complexes is more or less restricted as a consequence of drug binding as revealed by infrared linear dichroism. a fraction of dna is irreversibly locked into the b form. this behavior is described by the number of dna base pairs "frozen" in the b form by one drug molecule. this quantity is dependent on the dna sequence the drug is attached to. in this paper, drug complexes of oriented films of nadna with a gc content of 42% from calf thymus ... | 1990 | 2361002 |
| [atrophic rhinitis of swine: neutralization of the toxin of pasteurella multocida]. | the neutralization of the lethal as well as the growth-retarding action of the toxin on mice by an antitoxic serum is described. | 1990 | 2364889 |
| pasteurella multocida toxin, a potent mitogen, stimulates protein kinase c-dependent and -independent protein phosphorylation in swiss 3t3 cells. | pasteurella multocida toxin, either native or recombinant (rpmt), is an extremely effective mitogen for swiss 3t3 cells and acts at picomolar concentrations (rozengurt, e., higgins, t. e., chanter, n., lax, a. j., and staddon, j. m. (1990) proc. natl. acad. sci. u. s. a. 87, 123-127). here, we show that similar concentrations of rpmt markedly stimulated the phosphorylation of an acidic 80-kda protein in [32p]pi-labeled swiss 3t3 cells. co-migration on one- and two-dimensional gels and phosphopep ... | 1990 | 2365704 |
| the pathogenesis of pasteurella multocida serotype a:3,4 infection in turkeys: a comparison of two vaccine strains and a field isolate. | the pathogenesis of avian pasteurellosis caused by two vaccine strains, m-9 and clemson university (cu), and a highly virulent field isolate, 86-1913, of pasteurella multocida (serotype a:3,4) was studied in 7-week-old turkeys inoculated by an oculo-nasal-oral technique. turkeys inoculated with strain cu and isolate 86-1913 developed severe progressive bacteremia that began at 4 hours postinoculation (pi) and peaked at 16-20 hours pi. turkeys inoculated with strain cu and isolate 86-1913 had sig ... | 1990 | 2369373 |
| pasteurella multocida colonization and invasion in experimentally exposed turkey poults. | turkey poults were examined microbiologically to detect colonization and invasion following exposure to selected strains of pasteurella multocida. a variety of host tissues was examined 24 hours or less after exposure via the upper respiratory tract. recovery of p. multocida from the dorsal pharynx was used as an indicator of colonization; recovery from selected internal organs was used as an indicator of invasion. the frequency of colonization and invasion by capsulated and uncapsulated forms o ... | 1990 | 2369377 |
| virulence and toxigenicity of capsular serogroup d pasteurella multocida strains isolated from avian hosts. | five capsular serogroup d strains of pasteurella multocida isolated from avian hosts were examined for virulence and toxigenicity. virulence was based on development of lethal infections or lesions following intramuscular exposure of turkey poults. the four strains isolated from turkeys varied from slightly to moderately virulent; the strain isolated from a chicken was avirulent. poults exposed by intra-airsac inoculation with relatively few organisms of the more virulent of the strains had a hi ... | 1990 | 2369378 |
| differentiation of field isolates of pasteurella multocida serotype 3,4 from live vaccine strain by genotypic characterization. | fifty-five serotype 3,4 isolates of pasteurella multocida, isolated from turkeys dead from fowl cholera, were characterized (fingerprinted) genotypically for comparison with the serotype 3,4 live fowl cholera vaccine principally used in turkeys in california. twenty-three isolates were obtained from turkeys vaccinated with the m9 live vaccine, and 32 additional isolates were from turkeys not vaccinated for fowl cholera. methods of characterization included restriction endonuclease analysis of ch ... | 1990 | 2369381 |
| dermal necrosis caused by pasteurella multocida infection in turkeys. | severe dermal necrosis caused by pasteurella multocida serotype 1 was diagnosed in three dressed turkey carcasses and two live turkeys from a commercial flock. the dressed carcasses were among several condemned at a processing plant. the isolate, p. multocida serotype 1, produced progressive dermal necrosis when experimentally inoculated into injured skin of turkeys. the organism was reisolated from the dermal lesions. the turkey houses were found to be infested by mice; the skin injury and infe ... | 1990 | 2369388 |
| the downfield resonances in the 1h nmr spectra of azotobacter vinelandii and pseudomonas putida seven-iron ferredoxins. | pseudomonas putida and azotobacter vinelandii ferredoxins each contain one [4fe-4s] cluster and one [3fe-4s] cluster. their polypeptide chains are nearly identical, differing by only 15 residues out of a total of 106. t1 measurements and temperature dependence studies of the 1h nmr spectrum of each ferredoxin demonstrate that all six resolved downfield resonances are near an iron-sulfur center. the five most downfield resonances are shown to arise from protons on cysteinyl beta-carbons by incorp ... | 1990 | 2373698 |
| selective medium for pasteurella multocida and its use to detect oropharyngeal carriage in pig breeders. | a selective culture medium for isolation of pasteurella multocida was prepared by incorporating 2 mg of amikacin per liter, 4 mg of vancomycin per liter, and 4 mg of amphotericin b per liter into mueller-hinton blood agar. use of this medium revealed the presence of p. multocida in the oropharynges of 19 of the 49 pig breeders who were examined. | 1990 | 2380367 |
| pharmacokinetics of sulfadimidine and its n4-acetyl metabolite in healthy and diseased rabbits infected with pasteurella multocida. | the pharmacokinetics of sulfadimidine (sdm) and its n4-acetyl metabolite (n4sdm) were investigated after intravenous bolus injection of a single dose (200 mg/kg) of sdm in normal and diseased new zealand white rabbits. the apparent distribution volume at steady state, total body clearance and elimination half-life of sdm in normal animals were 0.7 +/- 0.3 l/kg, 0.57 +/- 0.24 l/kg/h and 1.6 +/- 1.3 h, respectively. of the administered dose, 62.1% was metabolized by n4-acetylation, and 12.7 +/- 1. ... | 1990 | 2384910 |
| stimulation of corneal endothelial wound healing in cats by mesodermal growth factor. | several growth factors have been evaluated for their effects on corneal wound healing but few studies have yet demonstrated an acceleration of endothelial repair in vivo. mesodermal growth factor (mgf) was tested in vivo by making standardized freeze wounds in cat corneas and immediately injecting one of four concentrations of mgf in sterile phosphate buffered saline (pbs), or pbs alone, into the anterior chamber. seven days later, the animals were sacrificed and the corneas excised and stained. ... | 1990 | 2387162 |
| pneumonia caused by pasteurella multocida. | | 1990 | 2391462 |
| characterization of envelope proteins from pasteurella haemolytica and pasteurella multocida. | a method was devised for the reproducible isolation of envelopes from pasteurella haemolytica serotype a2. it was also possible to prepare envelopes from other serotypes of p. haemolytica and pasteurella multocida using this methodology. examination of these preparations by sds-page showed major differences between strains of p. haemolytica and strains of p. multocida which allowed the clear distinction of isolates of these species. amongst the p. haemolytica serotypes it was possible to disting ... | 1990 | 2391489 |
| pasteurella multocida: a rare case of shunt infection. | pasteurella multocida, the major pathogen following an animal bite, is a rare cause of intracranial infection. this report documents the first case of ventriculo-peritoneal shunt infection with pasteurella multocida. | 1990 | 2397051 |
| a group of indole-negative bovine strains with high deoxyribonucleic acid homology to pasteurella multocida. | a group of nine bovine pasteurella strains not producing indole were investigated for their taxonomic relationships with pasteurella multocida, pasteurella haemolytica and pasteurella canis. for all strains, dna-dna hybridization has revealed a high genetic relatedness at the species level to p. multocida and significantly lower homologies of only 18-41% towards p. haemolytica and 11-15% towards p. canis. guanine plus cytosine values of 38.0 to 42.1 mol% and several phenotypic characters have be ... | 1990 | 2400530 |
| septicemia in vaccinated and nonvaccinated turkeys inoculated with pasteurella multocida serotype a:3,4. | sixty-four, 10-week-old turkeys were inoculated with a highly virulent field isolate (86-1913) of pasteurella multocida serotype a:3,4 by an oculo-nasal-oral route. inoculated turkeys were examined at 4, 8, 16, 20, and 24 hours post-inoculation for bacteremia and histologic lesions. bacteremia was detected in one of six turkeys 8 hours after inoculation and in four of six turkey poults at 16 hours post-inoculation. pasteurella multocida was isolated from the spleens of two turkeys at 8 hours and ... | 1990 | 2402853 |
| screening pig herds for toxigenic pasteurella multocida and turbinate damage in a health scheme for atrophic rhinitis. | the pig health control association launched a health scheme for atrophic rhinitis in 1978. for several years pig herds were monitored by scoring the degree of turbinate damage and by clinical inspections. when laboratory facilities became available for detecting toxigenic pasteurella multocida, nasal swabs were taken from pigs in association herds during 1988 and 1989 to determine whether the organism was present. sows were screened routinely and in the worst affected herds, sucklers and weaners ... | 1990 | 2402861 |
| reduced microbicidal activity of peripheral mononuclear phagocytic cells infected with pasteurella multocida. | pasteurella multocida inhibits the uptake and killing of candida albicans and p. multocida by avian mononuclear phagocytic cells. the toxic outer membrane protein of p. multocida, which has been previously described, also inhibited the uptake and killing of c. albicans. antibody specific for the toxic outer membrane protein reversed this effect resulting not only in an increase in uptake of c. albicans and p. multocida, but also in intracellular killing of p. multocida. this antibody, however, o ... | 1990 | 2407025 |
| pasteurella multocida meningitis. | the diagnosis of pasteurella multocida meningitis was confused by a false-positive latex particle agglutination test implicating group b streptococcus. this illness and false-positive reactions in antigen detection are discussed. | 1990 | 2407975 |
| a study on the pharmacokinetics in mouse of adenine-9-beta-d-arabinofuranoside 5-monophosphate conjugated with lactosaminated albumin. | in plasma of mice injected with adenine-9-beta-d-arabinofuranoside monophosphate (ara-amp) coupled to human lactosaminated serum albumin (l-hsa) some of the ara-amp molecules are enzymatically released, whereas others remain linked to l-hsa. evidence has been obtained that ara-amp is not deaminated when it is conjugated to l-hsa, in contrast to the free drug which is rapidly metabolized to its hypoxanthine derivative. | 1985 | 2412878 |
| visualization of metastases from colon carcinoma using an iodine 131-radiolabeled monoclonal antibody. | a murine monoclonal antibody that reacts with human colonic cancer (250-30.6) was labeled with radioactive iodine (131i) and the antibody was injected intravenously into 15 patients with known metastases originating from carcinoma of the colon (10 cases), malignant melanoma (1), breast (1), pancreas (1), hepatocellular carcinoma (1), and adenocarcinoma of unknown origin (1). of the patients with metastatic colon carcinoma, there were 19 known deposits as judged by the techniques of clinical exam ... | 1986 | 2417693 |