Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| pasteurella multocida ecthyma complicated by necrotizing fasciitis. | necrotizing fasciitis is a serious infection of the skin and soft tissues. pasteurella multocida is rarely reported to cause necrotizing fasciitis and is associated with high mortality. we describe a female patient with a past medical history of diabetes mellitus and myeloproliferative disorder presenting with bullae and erythema of the right forearm secondary to p. multocida infection after possible cat bite. despite adequate antibiotic coverage she developed necrotizing fasciitis diagnosed cli ... | 2017 | 28541874 |
| pharmacokinetic/pharmacodynamic evaluation of marbofloxacin as a single injection for pasteurellaceae respiratory infections in cattle using population pharmacokinetics and monte carlo simulations. | population pharmacokinetic of marbofloxacin was investigated with 52 plasma concentration-time profiles obtained after intramuscular administration of forcyl® in cattle. animal's status, pre-ruminant, ruminant, or dairy cow, was retained as a relevant covariate for clearance. monte carlo simulations were performed using a stratification by status, and 1000 virtual disposition curves were generated in each bovine subpopulation for the recommended dosage regimen of 10 mg/kg as a single injection. ... | 2017 | 28542866 |
| pharmacokinetic/pharmacodynamic integration and modelling of florfenicol for the pig pneumonia pathogens actinobacillus pleuropneumoniae and pasteurella multocida. | pharmacokinetic-pharmacodynamic (pk/pd) integration and modelling were used to predict dosage schedules for florfenicol for two pig pneumonia pathogens, actinobacillus pleuropneumoniae and pasteurella multocida. pharmacokinetic data were pooled for two bioequivalent products, pioneer and generic formulations, administered intramuscularly to pigs at a dose rate of 15 mg/kg. antibacterial potency was determined in vitro as minimum inhibitory concentration (mic) and mutant prevention concentration ... | 2017 | 28552968 |
| comparison of gene expression of toll-like receptors and cytokines between piau and commercial line (landrace×large white crossbred) pigs vaccinated against pasteurella multocida type d. | we aimed to compare toll-like receptors (tlr) and cytokines expression in local piau breed and a commercial line (landrace×large white crossbred) pigs in response to vaccination against pasteurella multocida type d. seronegative gilts for pasteurella multocida type d and mycoplasma hyopneumoniae were used, from which peripheral blood mononuclear cells (pbmc) were collected in four time points (t0, t1, t2 and t3; before and after each vaccination dose). for bronchoalveolar lavage fluid cells (bal ... | 2017 | 28554143 |
| pasteurella multocida chest wall abscess without wounds. | 2017 | 28560171 | |
| genome-wide analyses reveal genes subject to positive selection in pasteurella multocida. | pasteurella multocida, a gram-negative opportunistic pathogen, has led to a broad range of diseases in mammals and birds, including fowl cholera in poultry, pneumonia and atrophic rhinitis in swine and rabbit, hemorrhagic septicemia in cattle, and bite infections in humans. in order to better interpret the genetic diversity and adaptation evolution of this pathogen, seven genomes of p. multocida strains isolated from fowls, rabbit and pigs were determined by using high-throughput sequencing appr ... | 2017 | 28611758 |
| integrated pharmacokinetic-pharmacodynamic (pk/pd) model to evaluate the in vivo antimicrobial activity of marbofloxacin against pasteurella multocida in piglets. | marbofloxacin is a veterinary fluoroquinolone with high activity against pasteurella multocida. we evaluated it's in vivo activity against p. multocida based on in vivo time-kill data in swine using a tissue-cage model. a series of dosages ranging from 0.15 to 2.5 mg/kg were administered intramuscularly after challenge with p. multocida type b, serotype 2. | 2017 | 28619095 |
| identification of a large family of slam-dependent surface lipoproteins in gram-negative bacteria. | the surfaces of many gram-negative bacteria are decorated with soluble proteins anchored to the outer membrane via an acylated n-terminus; these proteins are referred to as surface lipoproteins or slps. in neisseria meningitidis, slps such as transferrin-binding protein b (tbpb) and factor-h binding protein (fhbp) are essential for host colonization and infection because of their essential roles in iron acquisition and immune evasion, respectively. recently, we identified a family of outer membr ... | 2017 | 28620585 |
| ducks as a potential reservoir for pasteurella multocida infection detected using a new romph-based elisa. | pasteurella multocida is an important pathogen of numerous domestic poultry and wild animals and is associated with a variety of diseases including fowl cholera. the aim of this study was to develop an indirect enzyme-linked immunosorbent assay (elisa) based on recombinant outer-membrane protein h (romph) for detection of anti-p. multocida antibodies in serum to determine their prevalence in chinese ducks. the p. multocida omph gene was cloned into pet32a, and romph was expressed in escherichia ... | 2017 | 28626158 |
| interaction between pasteurella multocida b:2 and its derivatives with bovine aortic endothelial cell (baec). | pasteurella multocida b:2 causes bovine haemorrhagic septicaemia (hs), leading to rapid fatalities in cattle and buffaloes. an attenuated derivative of p. multocida b:2 gdh7, was previously constructed through mutation of the gdha gene and proved to be an effective live attenuated vaccine for hs. currently, only two potential live attenuated vaccine candidates for hs are being reported; p. multocida b:2 gdh7 and p. multocida b:2 jrmt12. this study primarily aims to investigate the potential of p ... | 2017 | 28629460 |
| multipathogenic necrotising supraglottitis in an immunocompetent patient. | supraglottitis is a potentially life-threatening condition. it is now uncommon due to the haemophilus influenzae type b vaccination and is more recently caused by streptococcus pneumoniae, s. pyogenes, h. influenzae non-type b, h. parainfluenzae, staphylococcus aureus and pasteurella multocida very rarely, it can cause necrotising supraglottitis/epiglottitis, and this has been reported in immunocompromised individuals. we present a unique case of multipathogenic supraglottitis causing laryngeal ... | 2017 | 28630241 |
| impact of growth matrix on pharmacodynamics of antimicrobial drugs for pig pneumonia pathogens. | the most widely used measure of potency of antimicrobial drugs is minimum inhibitory concentration (mic). mic is usually determined under standardised conditions in broths formulated to optimise bacterial growth on a species-by-species basis. this ensures comparability of data between laboratories. however, differences in values of mic may arise between broths of differing chemical composition and for some drug classes major differences occur between broths and biological fluids such as serum an ... | 2017 | 28645327 |
| antibakterielle in-vitro-wirksamkeit ätherischer öle gegen veterinärmedizinisch relevante keime klinischer isolate von hunden, katzen und pferden. | einleitung: ätherische öle sind die grundlage der aromatherapie. unter anderem wird ihnen eine antibakterielle wirkung zugeschrieben. in dieser studie sollte die in-vitro-wirksamkeit ätherischer öle gegen ein breites spektrum veterinärmedizinisch relevanter erreger getestet werden. methoden: die antibakterielle aktivität von 16 ätherischen ölen wurde mittels agardiffusionstest bestimmt. getestet wurden grampositive und gramnegative erreger, die aus klinischen isolaten von hunden, katzen und pfer ... | 2017 | 28654923 |
| prediction of marbofloxacin dosage for the pig pneumonia pathogens actinobacillus pleuropneumoniae and pasteurella multocida by pharmacokinetic/pharmacodynamic modelling. | bacterial pneumonia in pigs occurs widely and requires antimicrobial therapy. it is commonly caused by the pathogens actinobacillus pleuropneumoniae and pasteurella multocida. marbofloxacin is an antimicrobial drug of the fluoroquinolone class, licensed for use against these organisms in the pig. in recent years there have been major developments in dosage schedule design, based on integration and modelling of pharmacokinetic (pk) and pharmacodynamic (pd) data, with the objective of optimising e ... | 2017 | 28666426 |
| simultaneous streptococcus canis and pasteurella multocida peritonitis in a peritoneal dialysis patient. | 2017 | 28676516 | |
| transcriptomic analysis on responses of murine lungs to pasteurella multocida infection. | pasteurella multocida infection in cattle causes serious epidemic diseases and leads to great economic losses in livestock industry; however, little is known about the interaction between host and p. multocida in the lungs. to explore a fully insight into the host responses in the lungs during p. multocida infection, a mouse model of pasteurella pneumonia was established by intraperitoneal infection, and then transcriptomic analysis of infected lungs was performed. p. multocida localized and gre ... | 2017 | 28676843 |
| in vitro treatment of lipopolysaccharide increases the invasion of pasteurella multocida serotype b:2 into bovine aortic endothelial cell. | pasteurella multocida serotype b:2 causes haemorrhagic septicaemia (hs) in cattle and buffaloes. the invasion mechanism of the bacterium to invade the bloodstream is unclear. this study aims to characterize the effects of immunomodulatory molecules, namely dexamethasone and lipopolysaccharide treatments, on the invasion efficiency of p. multocida serotype b:2 towards bovine aortic endothelial cells (baecs) and the involvement of actin microfilament in the invasion mechanism. the results imply th ... | 2017 | 28693312 |
| draft genome sequence of a virulent strain of pasteurella multocida isolated from alpaca. | pasteurella multocida is one of the most frequently isolated bacteria in acute pneumonia cases, being responsible for high mortality rates in peruvian young alpacas, with consequent social and economic costs. here we report the genome sequence of p. multocida strain unmsm, isolated from the lung of an alpaca diagnosed with pneumonia, in peru. the genome consists of 2,439,814 base pairs assembled into 82 contigs and 2,252 protein encoding genes, revealing the presence of known virulence-associate ... | 2017 | 28698737 |
| pharmacokinetic/pharmacodynamic modeling of tulathromycin against pasteurella multocida in a porcine tissue cage model. | tulathromycin, a macrolide antibiotic, is used for the treatment of respiratory disease in cattle and swine. the aim of our study was to investigate the in vitro and ex vivo activities of tulathromycin in serum, (non-inflamed) transudate, and (inflamed) exudate against pasteurella multocida in piglets. the pharmacokinetics properties of tulathromycin were studied for serum, transudate, and exudate using a tissue cage model. in vitro antibiotic susceptibility of p. multocida and dynamic time-kill ... | 2017 | 28701951 |
| wild mushrooms: a potential source of nutritional and antioxidant attributes with acceptable toxicity. | this paper describes in detail proximate composition, nutritional profile, phytochemical constituents, antioxidant activities, antimicrobial potential, and antihemolytic activity (towards human erythrocytes) of various fractions of wild ganoderma lucidum. proximate analysis established that wild g. lucidum comprises about 87.02±5.45% of moisture, and the remaining part is a rich source of proteins (8.59±0.37%), crude fiber (54.21±1.2%), and carbohydrate (35.16%) with smaller fat content (3.33 %) ... | 2017 | 28702429 |
| genome wide host gene expression analysis in mice experimentally infected with pasteurella multocida. | pasteurella multocida causes acute septicemic and respiratory diseases, including haemorrhagic septicaemia, in cattle and buffalo with case fatality of 100%. in the present study, mice were infected with p. multocida (1.6 × 103 cfu, intraperitoneal) to evaluate host gene expression profile at early and late stages of infection using high throughput microarray transcriptome analyses. several differentially expressed genes (degs) at both the time points were identified in p.multocida infected sple ... | 2017 | 28704394 |
| evaluation of a multiplex real-time pcr for detection of four bacterial agents commonly associated with bovine respiratory disease in bronchoalveolar lavage fluid. | pasteurella multocida, mannheimia haemolytica, histophilus somni and trueperella pyogenes are four bacterial agents commonly associated with bovine respiratory disease (brd). in this study a bacterial multiplex real-time pcr (the respocheck pcr) was evaluated for the detection in bronchoalveolar lavage fluid (balf) of these four bacterial agents. | 2017 | 28705198 |
| is submucosal fat injection effective in atrophic rhinitis? an experimental animal study. | atrophic rhinitis (ar) is a disease characterized by the extensive dilatation of the nasal cavity and atrophy of the mucosa, submucosa and bone tissue. its etiological factors are unknown. there is not a satisfying treatment yet and the treatment of the functional impairment in the atrophic cells is still subject to investigation. the objective of this study is to determine at the histopathological level the possible effects of the submucosal fat injection in an experimental model of ar. 12 albi ... | 2017 | 28707085 |
| pharmacokinetic-pharmacodynamic integration and modelling of oxytetracycline for the calf pathogens mannheimia haemolytica and pasteurella multocida. | a calf tissue cage model was used to study the pharmacokinetics (pk) and pharmacodynamics (pd) of oxytetracycline in serum, inflamed (exudate) and noninflamed (transudate) tissue cage fluids. after intramuscular administration, the pk was characterized by a long mean residence time of 28.3 hr. based on minimum inhibitory concentrations (mics) for six isolates each of mannheimia haemolytica and pasteurella multocida, measured in serum, integration of in vivo pk and in vitro pd data established ar ... | 2017 | 28736817 |
| whole-genome sequencing and concordance between antimicrobial susceptibility genotypes and phenotypes of bacterial isolates associated with bovine respiratory disease. | extended laboratory culture and antimicrobial susceptibility testing timelines hinder rapid species identification and susceptibility profiling of bacterial pathogens associated with bovine respiratory disease, the most prevalent cause of cattle mortality in the united states. whole genome sequencing offers a culture-independent alternative to current bacterial identification methods but requires a library of bacterial reference genomes for comparison. to contribute new bacterial genome assembli ... | 2017 | 28739600 |
| urinary tract infection with pasteurella multocida in a patient with cat exposure and abnormal urinary tract physiology: case report and literature review. | pasteurella multocida is a gram-negative organism that commonly colonizes the mouth of cats and dogs, and is known to cause infection in humans associated with animal bites or scratches. sites of infection other than skin and soft tissue are rare, but have been reported in patients with specific risk factors including anatomical abnormalities or immunosuppression. herein, we report a case of a symptomatic urinary tract infection caused by p. multocida in a 59 year old female who presented to the ... | 2017 | 28752063 |
| pasteurella multocida infection in a dog bite wound: a case report. | 1995 | 28769318 | |
| infection-stage adjusted dose of beta-lactams for parsimonious and efficient antibiotic treatments: a pasteurella multocida experimental pneumonia in mice. | in this study, the impact of infection stage on clinically and microbiologically efficacious doses and on antibiotic consumption was assessed during a naturally evolving infectious disease, using an original mouse model of pulmonary infection produced by air-borne contamination. when pasteurella multocida was administered as pathogenic agent to immunocompetent mice, 60% of the animals exhibited clinical symptoms of pneumonia 2 to 4 days after bacterial contamination of the lungs. two beta-lactam ... | 2017 | 28777819 |
| antimicrobial susceptibility, serotypes and genotypes of pasteurella multocida isolates associated with swine pneumonia in taiwan. | pasteurella multocida (pm) can cause progressive atrophic rhinitis and suppurative bronchopneumonia in pigs. the present study performed antimicrobial susceptibility testing and serotype and genotype identification on the 62 pm strains isolated from the lungs of diseased pigs with respiratory symptoms. antimicrobial susceptibility testing examined 13 antimicrobial agents (amoxicillin, cefazolin, doxycycline, flumequine, enrofloxacin, florfenicol, kanamycin, lincomycin, linco-spectin (lincomycin ... | 2017 | 28784694 |
| two novel cross‑protective antigens for bovine pasteurella multocida. | pasteurella multocida is an important pathogen that leads to a range of diseases that have severe economic consequences on cattle production. in order to develop an effective cross‑protective component vaccine, an immunoproteomics approach was used to analyze outer membrane proteins (omps) of the p. multocida serotype a, b and f strains. candidate antigen molecules from the whole genome were screened via linear trap quadrupole mass spectrometry and bioinformatics analysis, and the reactogenicity ... | 2017 | 28791368 |
| ompa protein sequence-based typing and virulence-associated gene profiles of pasteurella multocida isolates associated with bovine haemorrhagic septicaemia and porcine pneumonic pasteurellosis in thailand. | pasteurella multocida is a gram-negative bacterium that causes economically significant infections of a broad range of animal species. pneumonic and septicaemic pasteurellosis caused by this bacterium remain important problems in pigs, cattle, and water buffaloes in thailand. the aim of this study was to characterise the virulence-associated gene profiles and to develop an ompa molecular typing scheme for classifying 191 bovine and porcine isolates of p. multocida collected between 1989 and 2012 ... | 2017 | 28814302 |
| surveillance for hemorrhagic septicemia in buffalo (bubalus bubalis) as an aid to range expansion of the javan rhinoceros (rhinoceros sondaicus) in ujung kulon national park, indonesia. | the javan rhinoceros (rhinoceros sondaicus) of ujung kulon national park (uknp) is the crown jewel of indonesia's rich natural history. the park lies on a peninsula surrounded by coastline and agriculture-dominated landscapes. the invasion of water buffalo (bubalus bubalis) into the park carries a substantial health risk to the javan rhinoceros and threatens plans to establish a new population outside of its only current range in uknp. hemorrhagic septicemia (hs), known locally as septicemia epi ... | 2017 | 28820298 |
| a capsule/lipopolysaccharide/mlst genotype d/l6/st11 of pasteurella multocida is likely to be strongly associated with swine respiratory disease in china. | pasteurella multocida is a leading cause of respiratory disease in pigs worldwide. in this study, we determined the genetic characteristics of 115 p. multocida isolates from the lungs of pigs with respiratory disease in china in 2015 using capsular typing, lipopolysaccharide (lps) genotyping, and virulence genotyping based on the detection of virulence-associated genes. the results showed that the isolates belonged to three capsular types: a (49.6%), d (46.1%), and nontypable (4.3%); and two lps ... | 2017 | 28825122 |
| the myriad properties of pasteurella multocida lipopolysaccharide. | pasteurella multocida is a heterogeneous species that is a primary pathogen of many different vertebrates. this gram-negative bacterium can cause a range of diseases, including fowl cholera in birds, haemorrhagic septicaemia in ungulates, atrophic rhinitis in swine, and lower respiratory tract infections in cattle and pigs. one of the primary virulence factors of p. multocida is lipopolysaccharide (lps). recent work has shown that this crucial surface molecule shows significant structural variab ... | 2017 | 28825691 |
| molecular study on pasteurella multocida and mannheimia granulomatis from kenyan camels (camelus dromedarius). | outbreaks of a haemorrhagic septicaemia (hs) like disease causing large mortalities in camels (camelus dromedarius) in asia and in africa have been reported since 1890. yet the aetiology of this condition remains elusive. this study is the first to apply state of the art molecular methods to shed light on the nasopharyngeal carrier state of pasteurellaceae in camels. the study focused on hs causing pasteurella multocida capsular types b and e. other pasteurellaceae, implicated in common respirat ... | 2017 | 28830429 |
| development and standardization of an in-house indirect elisa for detection of duck antibody to fowl cholera. | serological tests, such as agglutination and indirect hemagglutination assay (iha), have been used to identify antibodies against pasteurella multocida in poultry sera, but none are highly sensitive. an enzyme-linked immunosorbent assays (elisa) has been used with varying degrees of success in attempts to monitor seroconversion in vaccinated poultry, but are not suitable for diagnosis. commercial elisa kits are available for chickens and turkeys, but not for ducks. the present study reports deve ... | 2017 | 28844720 |
| antimicrobial resistance in bacterial poultry pathogens: a review. | antimicrobial resistance (amr) is a global health threat, and antimicrobial usage and amr in animal production is one of its contributing sources. poultry is one of the most widespread types of meat consumed worldwide. poultry flocks are often raised under intensive conditions using large amounts of antimicrobials to prevent and to treat disease, as well as for growth promotion. antimicrobial resistant poultry pathogens may result in treatment failure, leading to economic losses, but also be a s ... | 2017 | 28848739 |