Publications

effect of illness on the family.		1995	162690
induction of human cell dna synthesis by herpes simplex virus type 2.	the effect of herpes simplex virus type 2 (hsv-2) infection on the synthesis of dna in human embryonic fibroblast cells was determined at temperatures permissive (37 c) and nonpermissive (42 c) for virus multiplication. during incubation of hsv-2 infected cultures at 42 c for 2 to 4 days or after shift-down from 42 to 37 c, incorporation of (3h)tdr into total dna was increased 2-to 30-fold as compared with mock-infected cultures. analysis of the (3h)dna suggested that host cell dna synthesis was ...	1975	163370
carcinoembryonic antigen in patients with gynecologic malignancies.	the determination of carcinoembryonic antigen (cea) in plasma has been of much interest currently concomitant with the search for an immunologic diagnosis test. recent reports have shed some doubt on the specificity of carcinoembryonic antigens for gastrointestinal tract malignancies. this report details the plasma cea values in 341 patients with varying gynecologic malignancies. these studies have demonstrated that plasma cea is elevated in close to 50 per cent of patients with invasive gynecol ...	1996	163585
investigation of factors of probable significance in the pathogenesis of pneumonic pasteurellosis in cattle.	six groups of ten beef calves six to eight months of age were shipped from western canada and observed untreated for one week after arrival. the following parameters were measured daily: body temperature, plasma fibrinogen, nasal bacterial mean colony counts of pasteurella hemolytica and pasteurella multocida, total and differential leukoyte counts, packed cell volumes and the following, twice during the week: serum and nasal antibody titres to p. hemolytica and parainfluenza-3 virus. the lungs ...	1975	164992
phytobezoar occurring as a complication of gastric carcinoma.	phytobezoar occurring as a complication of gastric carcinoma is reported for the first time. a review of the pathogenesis of phytobezoar suggests that hypomotility and hyposecretion are the two most important factors in bezoar formation. in the case discussed, hypomotility as a consequence of neoplastic involvement of the gastric antrum was the most important precipitating factor. however, documentation of prior hyposecretion was also noted and suggests that a combination of these two factors ma ...	2003	165135
letter: petechiae: due to adenovirus type 7 infection or to acetylsalicylic acid therapy?		1975	165451
electron-affinic sensitization. vi. a pulse radiolysis and esr comparison of some 2- and 5-nitroimidazoles.		2003	165564
glucose inhibiton of the permeation of chloromercuribenzene-p-sulphonic acid in the plasma membrane of pancreatic beta-cells.	the transport of chloromercuribenzene-p-sulphonic acid (cmbs) was studied in microdissected pancreatic islets of ob/ob mice incubated in krebs-ringer bicarbonate medium. glucose inhibited the islet uptake of cmbs. the initial binding of cmbs to superficial thiol groups was inhibited to a lesser extent than was its further permeation into the interior of the plasma membrane. the non-metabolized glucose analogue 3-0-methyl glucose had no effect on the permeation of cmbs. whereas mannoheptulose, ep ...	2003	165648
the measurement of choline kinase activity in rat brain: the problem of alternate pathways of atp metabolism.		1975	165749
cellular hypersensitivity to basic myelin (p2) protein in the guillain-barré syndrome.	lymphocytes of 29 subjects were assayed for mif production in response to p2 peripheral nerve protein, crude human peripheral nerve and human central nervous system al basic myelin protein. seven were performed in normal control subjects, 12 in guillain-barre patients (gb), 5 with other polyneuropathies and 5 in patients with multiple sclerosis (ms). only gb patients with acute illness produced mif in response to neuritogenic p2 protein and crude human nerve. two ms patients in the acute phase o ...	1975	165869
respiratory virus infections in children hospitalized in montreal, 1968 - 1972.		1975	165872
protein and glycoprotein electrophoretic patterns of enriched fractions of primary and secondary granules from guinea pig polymorphonuclear leukocytes.	the postnuclear supernatant fraction of sucrose homogenates of guinea pig polymorphonuclear leukocytes (pmnl) was subjected to differential centrifugation to obtain a total particulate fraction, a particle-free supernatant fraction, highly enriched fractions of primary and secondary granules, and a membrane-rich fraction. the various fractions were solubilized in buffer containing sodium dodecyl sulfate (sds) and analyzed for protein and glycoproteincomponents by sds -polyacrylamide gel electrop ...	1975	166079
the influence of sodium, potassium and lanthanum on amino acid release from spinal-medullary synaptosomes.		1975	166144
some aspects of corticosteroid-induced cleft palate: a review.	since the discovery 25 years ago that cortisone can produce cleft palate in mouse embryos investigations into possible mechanisms of this corticosteroid-induced defect have been many and varied. however, the teratogenic mode of action remains not fully clarified. it is with this thought in mind that we have reflected upon what is known concerning corticosteroids and cleft palate. the major metabolic pathways upon which glucocorticoids act as well as their intracellular mode of action are well kn ...	1975	166456
ectopic acth production in disseminated prostatic adenocarcinoma.	the second fully documented case of acth-producing prostatic adenocarcinoma with elevated plasma and tissue levels of acth is presented. the distinguishing characteristics of acth-producing extrapituitary neoplasms and the various modes of therapy are discussed.	2003	166477
improved chemical synthesis and enzymatic assay of delta-1-pyrroline-5-carboxylic acid.		1975	166569
reciprocal effects of camp and cgmp on microtubule-dependent release of lysosomal enzymes.		2003	167641
relationship between epstein-barr virus-associated nuclear antigen and cell viability in human cell lines.	the relationship between the cell viability and frequency of cell with epstein-barr virus (ebv)-associated nuclear antigen was investigated in cultures of 4 ebv-carrier lymphoblastoid cell lines, by means of anti-complement immunofluorescence. the percentages of viable cells and those of eb nuclear antigen-positive cells were close to each other in the entire course of cultivation of all cell lines. this leads to a conclusion that absence of eb nuclear antigen in a given cell population should b ...	1975	168112
antibody levels to parainfluenza, rubella, measles, and influenza a virus in children with polymyositis.	the cf and hi antibody titers to rubella and measles viruses, the cf titers to influenxa a, and the hi titers to parainfluenza 1, 2, and 3 were carried out on the sera of 20 patients with childhood polymyositis and their matched controls. the titers for measles, parainfluenxa 1, and influenza a were slightly higher for patients than for controls. the control group had antibody titers to rubella and parainfluenza 2 and 3 higher than or similar to those of patients. strong patterns or significant ...	1975	168906
appearance of sex hormone receptors in frog (rana esculenta) tadpole skin during metamorphosis.	in tadpole skin of rana esculenta, a specific testosterone receptor was detected during the climax in both males and females. the kass ranged between 1 and 2.79 x 10(9)m-1.	2003	169146
functional consequences of modifying highly reactive arginyl residues of fructose 1,6-bisphosphatase. loss of monovalent cation activation.	modification of pig kidney fructose 1,6-bisphosphatase with 2,3-butanedione (in the presence of amp) results in the loss of activation of the enzyme by monovalent cations. under these conditions about 8 arginyl residues per mole of enzyme were modified. no other residues were modified. no loss of monovalent cation activation occurs when modification with 2,3-butanedione is carried out in the presence of amp plus the substrate fructose 1,6-bisphosphate and 3.2 less arginyl residues were modified. ...	1975	169892
ultrastructure of human bronchiolo-alveolar cell carcinoma.	ultrastructural features were correlated with a series of special staining reactions in eight cases of bronchiolo-alveolar carcinoma. ultrastructural, all tumors were similarly composed of large cells with abundant cytoplasm and small nuclei in close contact with each other. straight membranes or complex interdigitations occurred within adjacent tumor cells, attached to each other by scattered desmosomes. microvilli or cilia abutted from free surfaces of the cells, and were noted in different st ...	1975	169987
on the lack of response to catecholamine stimulation by the adenyl cyclase system in psoriatic lesions.	when epidermis from the uninvolved skin of psoriatic patients was incubated for 5 min in hank's medium containing adrenaline and theophylline, the cyclic amp level consistently increased 20-30 times over the level observed when adrenaline was not added to the medium. on the other hand, when epidermis from the involved skin of psoriatic patients was incubated under the same experimental conditions, the cyclic amp level increased only 2-5 times. even when theophylline, and inhibitor of specific cy ...	2003	170954
atypical adrenal insufficiency with failure of the pituitary feedback receptor. a case with associated diabetes mellitus and selective iga deficiency with steatorrhea.	a 59 year old woman with insulin-dependent diabetes mellitus and chronic diarrhea was found to have mild steatorrhea, selective plasma iga deficiency and adrenal insufficiency. significant adrenal secretion of corticosteroids resulted only after prolonged stimulation with large doses of exogenous acth. plasma acth levels were not elevated during clinical adrenal insufficiency or after metyrapone administration but did respond normally to vasopressin and insulin-induced hypoglycemia. these studie ...	1990	171948
ascorbate increases the synthesis of procollagen hydroxyproline by cultured fibroblasts from chick embryo tendons without activation of prolyl hydroxyla.	an improved procedure was developed to extract prolyl hydroxylase from tendon cells of chick embryos with detergent, and improved assays were developed for both the activity of the enzyme and the amount of enzyme protein. freshly isolated tendon cells were found to contain approx. 100 mug of enzyme protein per 10(8) cells and 40-50% of the enzyme protein was active. when the cells were cultured, they were found to contain the same amount of enzyme protein but only 15-20% of the enzyme protein wa ...	1975	172137
effects of five to seven days of sleep deprivation produced by electrical stimulation of the midbrain reticular formation.		1975	172366
the estrogen cytosol receptor of female ovine pituitary.	the biochemical parameters of estrone and estradiol binding to the cytosol fraction of ovine anterior pituitary were investigated. when increasing amounts of [3h]estrone or [3h]estradiol were incubated with the 105,000 g fraction from the pituitary, both hormones bound to a receptor with the same apparent kd (mean +/- s.e., estrone = 1.40 +/- 0.30 x 10(-10) m, estradiol = 1.03 +/- 0.11 x 10(-10)m) and the same concentration of binding sites (estrone = 3.22 +/- 0.58 x 10(-14) moles/mg protein, es ...	1975	172395
reconstitution of bacillus stearothermophilus 50 s ribosomal subunits from purified molecular components.	bacillus stearothermophilus 50 s ribosomal subunits have been reconstituted from a mixture of purified rna and protein components. the protein fraction of 50 s subunits was separated into 27 components by a combination of various methods including ion exchange and gel filtration chromatography. the individual proteins showed single bands in a variety of polyacrylamide gel electrophoresis systems, and nearly all showed single spots on two-dimensional polyacrylamide gels. the molecular weights of ...	1976	172511
cytomegalovirus pulmonary disease.		1975	172837
[immunology of the placenta].		1995	173100
synthesis of fibroma viral deoxyribonucleic acid complexes in rabbit kidney cells.	cytoplasmic extracts of primary rabbit kidney cells inoculated with fibroma virus revealed 2 peaks of dna complexes (120s and greater than or equal to 410s) in a linear sucrose gradient. pulse-chase experiments demonstrated a shift in the gradient profile of lighter complexes toward heavier complexes. synthesis of dna complexes was inhibited by adding puromycin or actinomycin d. the dna from virus-infected cultures hybridized 7 to 9 times greater with fibroma virus dna than did the dna from noni ...	1975	173213
thin-layer chromatography of apomorphine and its analogs.		1996	173731
type-c rna viruses of the nih nude mouse.	several types of tumors from various species were propagated in nih athymic nude mice. subsequently, cell lines were established from the tumors and examined for evidence of type-c virus activity. hybrid mice (nih swiss and balb/c) harbored murine type-c viruses of three categories: n-tropic, b-tropic and x-tropic.	1975	173863
translation of the genes for the structural proteins of alphaviruses.	synthesis of the structural proteins of semliki forest virus by a cell-free system derived from mouse l-cells and programmed by intracellular 26s rna is described. this polycistronic rna is translated in vitro into several discrete polypeptides. the identity of these polypeptides as the structural proteins of the virus was established by polyacrylamide gel electrophoresis, immunoprecipitation and tryptic peptide mapping. studies using formyl--e135s]methionyl-trnaf as precursor, and using diphthe ...	1975	173941
[different pathogenic power of the original bcg strain of the pasteur institute and of an isoniazid resistant strain. histopathological study and significance of local abscesses after inoculation of guinea pig].	the inoculation into guinea pigs of 10 mg of bcg, obtained either from the pasteur institute original strain, or from a mutant isoniazid resistant strain, b1 catalase positive, caused in 40.4% of cases, the onset of abscesses at the point of injection. the frequency and course of these abscesses appear quite different with the two strains, 92.8% with the classical strain, persisting in more than half of the cases after one year, and 23.5% with the inh-resistant strains which regressed within 6 m ...	1975	174202
[changes in carbohydrate metabolism in hens experimentally infected with pasteurella multocida kokoshki].	studied were the concentration of blood sugar, the activity of glucose-6-phosphatase and glucose-6-phosphatedehydrogenase, and the level of glycogen in the liver of p. multocida infected chickens. an abrupt decrease of the liver glycogen was found as well as a negligible rise of the blood sugar. the activity of glucose-6-phosphatase remained unchanged, and that of glucose-6-dehydrogenase was twice as high. it is concluded that the intense exhaustion of liver glycogen is in connection with the ac ...	1975	174282
pasteurella multocida septicaemia associated with chronic liver disease.		1975	174776
human cancer viruses.		1976	175647
[changes in the sensitivity of developing sea urchin embryos to prostaglandin f2alpha and cyclic 3',5'-adenosine monophosphate].	it was shown that at various stages of the first mitotic cycles the developing ova of strongylocentrotus intermedius displayed a different sensitivity to toxic concentrations of prostaglandin f2alpha and to cyclic 3',5'-adenosinmonophosphate (camp). the differences in the sensitivity to each of these substances were regular and similar in character and depended on the time lapse after the completion of division next in turn. there were revealed two periods of increased sensitivity of the ova--th ...	1988	175867
epstein-barr virus in an american patient with burkitt's lymphoma: detection of viral genome in tumor tissue and establishment of a tumor-derived cell line (nab).	epstein-barr virus (ebv) dna (17.7 genome equivalents/cell) was found in tumor tissue from an american patient with burkitt's lymphoma who had never traveled outside the united states. a lymphoid cell line (nab) containing the ebv genome was established from tumor tissue from this patient; characteristics of this cell line were described. previous burkitt's tumors found in americans and examined by molecular hybridization were negative for ebv dna. our results suggested that ebv is associated wi ...	1976	176407
stepwise transition of aggregate structure of high-molecular-weight avian myeloblastosis virus rna. mode of releasing of associated 4s rna.	mode of releasing of associated 4s rna species was studied during a controlled transition of aggregate structure of high-molecular-weight amv-rna. it has been found that associated 4s rna constitutes 2.5% of 60s amv-rna complex. approximately 60% of associated 4s rna is successively released during treatment of viral rna with increasing formamide concentration, concomitantly with the transition of 60s rna aggregate through 50--55s rna intermediate into the final 30--40s rna subunits. 40% of 4s r ...	1976	180440
start early to engineer against noise.		1981	181712
further studies on the neonatal ferret model of infection and immunity to and attenuation of human parainfluenza viruses.	earlier we reported on the susceptibility via the intranasal route of inoculation of newborn ferrets to infection by wild and serially egg passaged parainfluenza type 3 virus. the wild type consistently induced fatal infection whereas with serial egg passage, mortality rate decreased while the degree of infectivity remained the same. this attenuation was accompanied by a change in capacity to induce interferon and decreased growth in human and primate cell cultures. the present work reports, sim ...	1976	182598
inflammatory cells in solid murine neoplasms. i. tumor disaggregation and identification of constituent inflammatory cells.	mechanical and enzymatic methods of disaggregating tumors were studied with the goals of (1) minimizing cell losses while (2) maintaining functional and surface membrane markers needed to objectively identify inflammatory cells (ic)1 in resultant suspensions. application of the principles and methods described makes accurate estimation of the percentage of each ic type present in neoplasms possible for the first time. compared to purely mechanical means of disaggregating tumors, all enzyme mixtu ...	1976	182647
ultrastructural cytology of prostate carcinoma cells from wistar rats.	cells from spontaneous adenocarcinomas of the prostate (pollard, m.: j. natl. cancer inst. 51: 1235, 1973) in aged lobund wistar rats were examined by electron microscopy. cytologic structures of the rat prostate tumor cells resembled analogous structures from human prostate tumor cells. these findings support the prospect that the rat prostate tumor will provide a model system of prostate cancer in man.	1976	184062
nursing care in a combined adolescent medical-psychiatric unit.	in spite of the problems we have encountered in combining adolescent medical and psychiatric patients, we have found this to be a workable model. in summary, several areas are important in making this model functional: staff interest in both medical and psychiatric patients, in-service programs particularly in psychiatry, and open communication between health care givers. certainly one of the most positive aspects of this unit is that it provides an environment which allows for easier adjustment ...	1983	185375
virologic study of common colds in peking, 1971-1973.		1994	186234
the release of endogenous amino acids from the rat visual cortex.	the release of endogenous taurine, gaba, glycine, aspartate, glutamate, glutamine and alanine from the rat visual cortex was measured using a cortical cup technique. the electrocorticogram (ecog) was monitored throughout most experiments. 2. spreading depression, evoked by the dropwise placement of 10% kcl solution on to the brain outside the cup was associated with a significant increase in the release of gaba and glutamine but a marked fall in that of glutamate. the evoked release of gaba and ...	1976	186588
enkephalins and endorphins: a major discovery.		2002	186644
the effect of lymphoma and other neoplasms on hepatic and plasma enzymes of the host rat.	considerable thymidine kinase and pyrroline-5-carboxylate reductase activities were found in the plasma of rats bearing a transplanted lymphoma; neither activity was detected in plasma of hosts carrying hepatic, renal, mammary, or submaxillary gland tumors. all host livers exhibited signs of biochemical immaturity as indicated by the appropriate increases or decreases in the concentrations of the nine enzymes measured. the extent and time schedule of the changes in host liver varied with the enz ...	1977	187334
the caudal neurosecretory system. a critical evaluation of the two-hormone hypothesis.	recent information on the caudal neurosecretory system (urophysis) is collated, with special reference to cellular biology including neural relations, activity and chemistry 8 the biological principles associated with the urophysis, pharmacological analysis of the receptors for these principles, and their possible functions in a physiological sense. the existence of at least two principles, urotensins i and ii, is well established. they differ pharmacologically and chemically and may arise from ...	2003	187342
localization of ouabain-sensitive, potassium-dependent nitrophenyl phosphatase in the rectal gland of the spiny dogfish, squalus acanthias.	tissue from the digitiform rectal gland of the spiny dogfish, squalus acanthias, was fixed briefly by formaldehyde perfusion and studied for the specificity and localization of p-nitrophenyl phosphatase (npp'ase) activity. the enzymatic activity was k+-dependent (56%) and ouabain-sensitive (67%-inhibition). the electron-dense reaction product (srpo4) of the cytochemical reaction (ernst, 1972b) was localized along the inner surfaces of the basolateral membranes of the secretory cells. it was abse ...	2003	187344
plasma camp and renin in diabetics during insulin induced hypoglycemia.		2002	187538
interrelationships between the central nervous system and patterns of adrenocorticotropic secretion following acute exposure to severe environmental conditions.		1976	187557
[the physician and lourdes].		2003	187858
serum modulation of in vitro cellular immune reactivity to epstein-barr virus-associated antigen.	the reactivity of peripheral blood leukocytes to epstein-barr virus-associated antigen was assessed employing two in vitro tests, leukocyte adherence inhibition (lai) and leukocyte migration inhibition (lmi). in both tests, autologous serum from some normal subjects was shown to confer strong reactivity on weak or non-responder cells. reactivity to purified protein derivative of tuberculin (ppd) assessed in parallel was shown to be unaffected by autologous serum. employing the lai system, variat ...	1976	187919
[epidemiology of congenital abnormalities in newborn infants in the city of vilnius].		1997	192105
amino acid concentrating ability of slowly growing autochthonous hepatomas and host livers.		1977	192232
a study of 200 children evaluated and reevaluated for possible mental retardation.		1993	192782
peripheral neuropathy: a side effect of sulphones.		2003	193605
regulation of norepinephrine release from cardiac sympathetic fibers in the dog by presynaptic alpha- and beta-receptors.	the effect of phenoxybenzamine (pba), desmethylimipramine (dmi), clonidine (clnd), sotalol (stl), and isoproterenol (ispr) on the release of endogenous norepinephrine (ne) from the heart on right cardioaccelerator nerve stimulation was studied in anesthetized dogs. under control conditions, the catecholamine levels in coronary sinus blood increased linearly with increasing frequencies of stimulation up to 10 hz and did not increase further at 30 hz. the release of ne was markedly enhanced after ...	1977	193655
glucose-induced proinsulin biosynthesis. role of islet cyclic amp.		1977	193750
acute interstitial pneumonia [proceedings].		1977	193807
the storage lipids in tangier disease. a physical chemical study.	the physical states and phase behavior of the lipids of the spleen, liver, and splenic artery from a 38-yr-old man with tangier disease were studied. many intracellular lipid droplets in the smectic liquid crystalline state were identified by polarizing microscopy in macrophages in both the spleen and liver, but not in the splenic artery. the droplets within individual cells melted sharply over a narrow temperature range, indicating a uniform lipid composition of the droplets of each cell. howev ...	1977	193870
autotransplantation of pancreatic islets without separation of exocrine and endocrine tissue in totally pancreatectomized dogs.	the aims of this study were to determine whether diabetes could be ameliorated in dogs by autotransplantation of pancreatic fragments to the spleen and to determine the optimal time of collagenase digestion for pancreatic tissue dispersal. forty-eight dogs were made diabetic by total pancreatectomy. fifteen dogs not further treated survived 7.0+/-1.1 (se) days with a mean plasma glucose of 401+/-5 (se) mg/100 ml 2 days after pancreatectomy. the pancreases of 33 dogs were distended with hanks' so ...	1977	195358
[plasma levels of aldosterone and acth and renin activity during spinal anesthesia and surgery].		1993	196122
interaction between isoprenaline and aminophylline in asthma.		2003	201045
what is your diagnosis?		1992	205807
presynaptic localization of opiate receptors in the vagal and accessory optic systems: an autoradiographic study.		1978	206855
circular dichroism and circular polarization of luminescence of reduced nicotinamide adenine dinucleotide in solution and bound to dehydrogenases.	the cd (circular dichroism) and cpl (circular polarization of luminescence) spectra of nadph in aqueous solution were studied and found to be markedly different. the spectra were not affected by cleavage of the coenzyme molecule with phosphodiesterase. the differences are thus not due to the existence of extended and folded conformations of nadph and it is concluded that they originate in excited state conformational changes of the nicotinamide--ribose fragment. opposite signs of both the cd and ...	1978	207311
multiple forms of cyclic nucleotide phosphodiesterases: anomalies or biologic regulators?		1991	208379
vaccination immunity to selected diseases in chickens fed the androgen analog mibolerone.	chickens fed the androgen analog mibolerone during the first 7 weeks of life regress their bursa of fabricius but can be properly immunized by vaccination against avian pathogens of major economic importance such as newcastle disease virus, infectious laryngotracheitis virus, avian encephalomyelitis virus, infectious bronchitis virus, fowl pox virus, marek's disease virus, and pasteurella multocida, the pathogen causing fowl cholera. these findings on immunocompetence to infectious agents are im ...	1978	209430
characteristics of lead ion-stimulated phosphorylation of electrophorus electricus electroplax (na+ + k+)-adenosine triphosphatase and inhibition of atp-adp exchange.	pb2+-stimulated phosphorylation of electrophorus electricus electroplax (na+ + k+)-adenosine triphosphatase is prevented by stoichiometric quantities of 2,3-dimercaptopropanol. the chelator in the same low concentrations does not block na+-dependent phosphorylation. both pb2+-and na+-dependent phosphorylation reactions show the same dependence on mgcl2. phosphorylation in the presence of both na+ and pb2+ is cumulative suggesting that pb2+ and na+ bind at separate, independent sites. the enthalp ...	1987	212419
comparison of interferon action in interferon resistant and sensitive l1210 cells.	translation inhibition, leu-trna aminoacylation and double-stranded rna and atp dependent phosphorylation were examined in interferon-treated and control cell-free lysates of leukaemic mouse l 1210 r and l 1210 s cells. no differences were observed between the respective interferon-treated and control cell-free extracts, except for the presence of an enhanced 67k dalton phosphoprotein fraction in interferon-treated l 1210 s cell-free extracts. in non-responding cell-free lysates, the lack of sti ...	1978	212514
effect of polymyxin b sulfate on endotoxin activity in a gram-negative septicemia model.	the antiendotoxin effect of polymyxin b was investigated in experimentally induced septicemia in rabbits. the pasteurella multocida organisms were sensitive to the antibacterial action of penicillin but not to polymyxin b. animals pre-treated with polymyxin showed positive blood cultures and significantly reduced plasma endotoxin levels (limulus test) with normal white blood cell and platelet counts when analyzed 6 hr after the injection of live organisms. polymyxin therapy given after the anima ...	1979	219410
observations on outbreaks of respiratory disease in housed calves--(1) epidemiological, clinical and microbiological findings.	in 47 of 50 outbreaks of respiratory disease in indoor calves which had never been to grass there was clinical evidence of pneumonia in all animals examined. calf housing was in most cases considered unsatisfactory. virus activity was detected in 70 per cent of outbreaks investigated within a few days post onset of respiratory signs. parainfluenza (pi) 3 and respiratory syncitial virus (rsv) were the viruses most frequently involved. in the majority of outbreaks mycoplasma species and pasteurell ...	1978	219582
secretory granules of the duodenal enterochromaffin cells of the cat.		1979	222959
presynaptic receptor systems on cardiac sympathetic nerves.		2003	222983
lymphocyte transformation for the detection of herpesvirus-induced tumor-associated antigens.	cell-mediated immunity to fibroblasts transformed by herpes simplex virus type 2 was investigated with a lymphocyte assay system. the assay system was first standardized with phytohemagglutinin, a nonspecific stimulator of blastogenesis. hamster splenic and blood lymphocytes reacted to phytohemagglutinin with a dose-response curve similar to that reported for other rodent species. splenic lymphocytes from hamsters bearing isografts, induced by herpes simplex virus type 2, were transformed by cel ...	1979	225013
morphological revertants of an avian sarcoma virus-transformed mammalian cell line exhibit tumorigenicity and contain pp60src.	the biological and biochemical properties of rous sarcoma virus-transformed and revertant field vole cells were investigated. revertant vole cells appear morphologically similar to normal, uninfected cells, yet, like transformed vole cells, they are fully capable of growing in agar suspension and producing tumors in athymic nude mice. these highly tumorigenic, yet morphologically normal appearing, vole cells express viral-specific antigens such as the gag gene product (pr76) but lack the env gen ...	1979	226988
cholinergic activity regulates muscarinic receptors in central nervous system cultures.	muscarinic acetylcholine receptor activation induces a loss of muscarinic receptors from cultured neuroblastoma and embryonic chicken cerebrum cells. as measured by specific binding of [3h]quinuclidinyl benzilate, steady-state receptor concentrations decrease 75% in response to receptor-saturating concentrations of cholinomimetic drugs. both the degree and duration of activation determine the extent of receptor loss. a method for analyzing receptor turnover, which does not rely upon protein synt ...	1979	226997
some major consequences of actions of drugs on the autonomic nervous system in man and experience of prediction from animal studies.		1979	227001
photodynamic therapy for herpes simplex: a critical review.		1979	227002
hormones and their effects in the aging body.		2003	227057
evaulation of the potency of antipertussis serum products.		1979	227908
a radioimmunoassay for hepatitis a antigen and antibody.	the havab radioimmunoassay for the detection of antibody to hepatitis a is assessed. its modification to detect virus in faecal samples is described and in this it was found to be more sensitive and specific than electron microscopy.	1979	227943
isolation and characterization of polyoma virus genomes with deletions between the origin of viral dna replication and the site of initiation of translation in the early region.	we introduced deletions in the early region of the polyoma virus genome near the haeii restriction enzyme cleavage site, between the origin of viral dna replication and the site of initiation of translation of the polyoma t antigens. we analyzed the dna of the deletion mutants by restriction enzyme digestion. four of the mutants had deletions beginning very close to the haeii site and extending clockwise toward the site of initiation of translation. the deletions near the haeii site varied in si ...	1979	228074
[renal lesions in myelofibrosis (author's transl)].	in 26 cases of myelofibrosis, the authors investigated for possible renal impairment that can be appraised from the usual clinical, laboratory, and roentgenographic signs. no anomalies were demonstrated in 12 of these cases. in 14 (or 53%) of the patients, some anomaly was discovered : essentially proteinuria with minor alteration of renal function, but also, two cases of poorly functioning left kidney evidenced on intravenous urograms, one case of acute anuric renal failure connected with hyper ...	1995	228398
[eye burns].		1995	228432
the kinetics of tubocurarine action and restricted diffusion within the synaptic cleft.	1. the kinetics of tubocurarine inhibition were studied at the post-synaptic membrane of frog skeletal muscle fibres. acetylcholine (ach) and (+)-tubocurarine were ionophoresed from twin-barrel micropipettes, and the membrane potential of the muscle fibre was recorded intracellularly. tubocurarine-receptor binding was measured by decreases in the response to identical pulses of ach. 2. the responses to both ach and tubocurarine had brief latencies and reached their maxima rapidly. it is suggeste ...	1996	229214
[analysis of failures of chemotherapy of pulmonary tuberculosis in adults].		1979	229540
[ecological studies of vesicular stomatitis in antioquia, colombia].		1979	229882
the interaction of calcium and magnesium ions with deoxyribonucleic acid.		1975	240314
[muscular dystrophy].		1991	245179
clinical sensory deprivation: a comparative study of patients in single care and two-bed rooms.		1991	245396
[i learn a lesson from the death of mr. y. who had been fighting against pain].		1992	245461
peritonitis due to pasteurella multocida in a rabbit.		1979	255014
scleroderma: the more you know, the more you can help.		1992	257011
when a patient attacks: strategies for self-protection when violence looms.		1991	257723
[systems theory: stress, adaptation].		1991	257854