| inhibitory activity of aloe vera gel on some clinically isolated cariogenic and periodontopathic bacteria. | aloe vera is a medicinal plant with anti-inflammatory, antimicrobial, antidiabetic and immune-boosting properties. in the present study we investigated the inhibitory activities of aloe vera gel on some cariogenic (streptococcus mutans), periodontopathic (aggregatibacter actinomycetemcomitans, porphyromonas gingivalis) and an opportunistic periodontopathogen (bacteroides fragilis) isolated from patients with dental caries and periodontal diseases. twenty isolates of each of these bacteria were i ... | 2012 | 22466882 |
| aggregatibacter actinomycetemcomitans infection enhances apoptosis in vivo through a caspase-3-dependent mechanism in experimental periodontitis. | the purpose of this study was to test the hypothesis that diabetes aggravates periodontal destruction induced by aggregatibacter actinomycetemcomitans infection. thirty-eight diabetic and 33 normal rats were inoculated with a. actinomycetemcomitans and euthanized at baseline and at 4, 5, and 6 weeks after inoculation. bone loss and the infiltration of polymorphonuclear leukocytes (pmns) in gingival epithelium were measured in hematoxylin-eosin-stained sections. the induction of tumor necrosis fa ... | 2012 | 22451521 |
| specificity of antimicrobial peptide ll-37 to neutralize periodontopathogenic lipopolysaccharide activity in human oral fibroblasts. | the antimicrobial peptide ll-37 is known to have a potent lipopolysaccharide (lps)-neutralizing activity in various cell types. because of observed heterogeneity within periodontopathogenic lps, the authors hypothesized that ll-37 had specificity to neutralize such lps activity. the present study, therefore, aims to investigate the lps-neutralizing activity of ll-37 to various periodontopathogenic lps in interleukin-8 (il-8) production after challenging them in human oral fibroblasts. | 2013 | 22443521 |
| individual composition of human leukocyte antigens and periodontopathogens in the background of periodontitis. | human leukocyte antigens (hlas) are a basic precondition to induce the immune response to pathogens. therefore, this study evaluates associations among periodontitis, five key periodontopathic bacteria, and hlas to test their impact together with additional risk factors in multivariate analyses. | 2013 | 22443520 |
| increased levels of porphyromonas gingivalis are associated with ischemic and hemorrhagic cerebrovascular disease in humans: an in vivo study. | this study investigated the role of periodontal disease in the development of stroke or cerebral infarction in patients by evaluating the clinical periodontal conditions and the subgingival levels of periodontopathogens. | 2012 | 22437687 |
| microbial profiles of patients seeking treatment for periodontitis. influence of origin, smoking and age? | we assessed the potential influence of the origin, the smoking status and the age on subgingival microbial profiles of subjects seeking periodontal care in switzerland today. | 2012 | 22419513 |
| distribution of periodontopathic bacterial species in dogs and their owners. | presently, a large number of individuals consider their companion animals as family members and have close contact with them in daily life. the purpose of the present study was to analyze the distribution of periodontopathic bacterial species in oral specimens taken from dogs and their owners. | 2012 | 22417880 |
| the green tea polyphenol (-)-epigallocatechin gallate precipitates salivary proteins including alpha-amylase: biochemical implications for oral health. | green tea is a popular drink throughout the world, and it contains various components, including the green tea polyphenol (-)-epigallocatechin gallate (egcg). tea interacts with saliva upon entering the mouth, so the interaction between saliva and egcg interested us, especially with respect to egcg-protein binding. sds-page revealed that several salivary proteins were precipitated after adding egcg to saliva. matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (maldi-tof ... | 2012 | 22409219 |
| genome sequence of a serotype b non-jp2 aggregatibacter actinomycetemcomitans strain, anh9381, from a periodontally healthy individual. | gram-negative aggregatibacter actinomycetemcomitans can be distinguished (based on the promoter structure of the leukotoxin operon) into jp2 and non-jp2 genotypes, with the former found to be more pathogenic than the latter. here we report the first complete genome sequence of a serotype b non-jp2 strain of a. actinomycetemcomitans. | 2012 | 22408240 |
| pdt in non-surgical treatment of periodontitis in hiv patients: a split-mouth, randomized clinical trial. | the aim of this study was to evaluate the clinical and microbiological effect of photodynamic therapy (pdt) in the non-surgical treatment of periodontitis in hiv patients. | 2012 | 22407618 |
| clinical and microbiological evaluation of high intensity diode laser adjutant to non-surgical periodontal treatment: a 6-month clinical trial. | this randomized split-mouth clinical trial was designed to evaluate the efficacy of scaling and root planing associated to the high-intensity diode laser on periodontal therapy by means of clinical parameters and microbial reduction. | 2013 | 22402617 |
| comparative evaluation of the effects of different photoablative laser irradiation protocols on the gingiva of periodontopathic patients. | we aimed at quantifying the presence of periodontopathogens in gingival biopsies from periodontitis patients treated with different photoablative lasers (diode gaas, er:yag, nd:yag, and co(2) lasers) and histologically analyzing their effects on the gingiva. | 2012 | 22401128 |
| atomic force spectroscopy evidence of non-specific adhesion of aggregatibacter actinomycetemcomitans. | aggregatibacter actinomycetemcomitans is a gram-negative periodontopathogen found within the subgingival plaque on the tooth surface. it is associated with localized aggressive periodontitis, a severe form of periodontitis in adolescents, and is the cause various extra-oral infections. the ability of this organism to tenaciously adhere to abiotic surfaces has been attributed to bundle-forming type ivb-like fimbriae whose major component is the fimbrial lower molecular weight protein (flp). in th ... | 2011 | 22400208 |
| the association of aggregatibacter actinomycetemcomitans with preeclampsia in a subset of japanese pregnant women. | to determine whether periodontitis and three prominent members of the periodontal flora are associated with the development of preeclampsia (hypertension plus proteinuria) materials and methods: the samples were composed of 127 systemically healthy women. within 5 days after labour, clinical periodontal parameters and aggregatibacter actinomycetemcomitans, porphyromonas gingivalis and prevotella intermedia in subgingival plaque were evaluated. maternal serum igg antibody specific for each bacter ... | 2012 | 22393563 |
| immunoregulatory gene polymorphisms in japanese women with preterm births and periodontitis. | many studies have reported an association between periodontal disease and preterm birth, although this remains controversial. cytokines and antibodies produced to give resistance to infection can enter the bloodstream and cause preterm labor. we analyzed maternal genetic polymorphisms in various immunoregulatory genes that could affect both preterm birth and periodontitis. a total of 1099 women referred to the department of obstetrics and gynecology, niigata university medical and dental hospita ... | 2012 | 22382006 |
| presence of jp2 and non-jp2 genotypes of aggregatibacter actinomycetemcomitans and attachment loss in adolescents in ghana. | limited data are reported concerning the presence of a. actinomycetemcomitans and attachment loss (al) in sub-saharan countries. the authors investigate the carrier frequency of jp2 and non-jp2 genotypes of a. actinomycetemcomitans and the presence of al in ghanaian adolescents and evaluate socioeconomic conditions and oral hygiene practices. | 2012 | 22376208 |
| oral microbiota in swiss adolescents. | the purpose of the study was to determine the prevalence of different oral microbes in gingival plaque samples and in samples from the dorsum of the tongue in a swiss adolescent population. | 2013 | 22371122 |
| [dissertations 25 years after date 31. black-pigmented oral bacteria in human oral infections]. | in 1986, oral microbiology, and especially the microbiology of periodontal infections, was of central importance. interest in periodontology was growing rapidly and with it, interest in developments in microbiology and the immunology of infectious diseases of the periodontium. at national and international meetings discussions took place concerning the role of the newly discovered bacterial species actinobacillus actinomycetemcomitans and the role of antibiotics in the treatment of severe period ... | 2012 | 22368841 |
| [effect of periodontal surgery on the subgingival periodontal microbiota in artificial class iii furcation defects: an experimental study in monkeys]. | this study was to longitudinally evaluate the change of prevalence of five periodontal putative pathogens in the subgingival plaque of artificial class iii furcation defects at the three time-points, including before the establishment of furcation defects, before and 6 months after periodontal surgery. | 2012 | 22353894 |
| infection of human gingival fibroblasts with aggregatibacter actinomycetemcomitans: an in vitro study. | aggregatibacter actinomycetemcomitans is known to be a major cause of localized aggressive periodontitis. previous research has suggested that a. actinomycetemcomitans can damage many types of host cells. there is evidence for the ability of this organism to invade endothelial and epithelial cells, but information pertaining to its potential for invading gingival fibroblasts is very limited. internalization of bacteria is not only responsible for damaging host tissue but also a means to evade th ... | 2012 | 22348592 |
| genome sequence of aggregatibacter actinomycetemcomitans rhaa1, isolated from a rhesus macaque, an old world primate. | aggregatibacter actinomycetemcomitans is implicated in localized aggressive periodontitis. we report the first genome sequence of an a. actinomycetemcomitans strain isolated from an old world primate. | 2012 | 22328766 |
| rapid identification of oral isolates of aggregatibacter actinomycetemcomitans obtained from humans and primates by an ultrafast super convection based polymerase chain reaction. | aggregatibacter actinomycetemcomitans is a gram negative oral bacterium associated with localized aggressive periodontitis (lap). detection of a. actinomycetemcomitans in clinical samples is routinely done by pcr. our aim was to develop a rapid and reliable pcr method that can be used as a chair-side tool to detect a. actinomycetemcomitans in clinical samples. sensitivity and specificity assessment was performed on buccal and plaque samples obtained from 40 adolescents enrolled in an ongoing lap ... | 2012 | 22326236 |
| azithromycin as an adjunctive treatment of generalized severe chronic periodontitis: clinical, microbiologic, and biochemical parameters. | this study examines the efficacy of azithromycin in combination with non-surgical periodontal therapy on clinical and microbiologic parameters and gingival crevicular fluid (gcf) matrix metalloproteinases-8 (mmp-8) levels over 6 months in patients with severe generalized chronic periodontitis (cp). | 2012 | 22324488 |
| antibacterial activity of the lactoperoxidase system combined with edible laminaria hot-water extract as a source of halide ions. | hot-water extracts prepared from nine out of 12 samples of dried edible laminaria reduced the viable numbers of aggregatibacter actinomycetemcomitans, staphylococcus aureus, and esherichia coli below the detection limit after incubation for 5 min when combined with lactoperoxidase, glucose oxidase, and glucose. some extracts showed higher bactericidal activity and a higher oi(-) concentration in the assay mixture after ultrafiltration. | 2012 | 22313780 |
| detection of periodontal bacteria in thrombi of patients with acute myocardial infarction by polymerase chain reaction. | numerous reports have demonstrated that periodontal bacteria are present in plaques from atherosclerotic arteries. although periodontitis has recently been recognized as a risk factor for coronary artery disease, the direct relationship between periodontal bacteria and coronary artery disease has not yet been clarified. it has been suggested that these bacteria might contribute to inflammation and plaque instability. we assumed that if periodontal bacteria induce inflammation of plaque, the bact ... | 2012 | 22305832 |
| no association between a actinomycetemcomitans or p gingivalis and chronic or aggressive periodontitis diagnosis. | only a few studies have attempted to detect differences in microbiologic profiles of patients with chronic periodontitis (cp) and aggressive periodontitis (agp). the aim of this analysis was to assess if clinical diagnosis or other subject factors showed association with the presence of actinobacillus actinomycetemcomitans and porphyromonas gingivalis in a cohort of periodontitis patients. | 2012 | 22299125 |
| the combination of amoxicillin and metronidazole improves clinical and microbiologic results of one-stage, full-mouth, ultrasonic debridement in aggressive periodontitis treatment. | the aim of the present study is to assess clinical, microbiologic, and immunologic benefits of amoxicillin/metronidazole (am) when performing full-mouth ultrasonic debridement (fmud) in generalized aggressive periodontitis (gagp) treatment. | 2012 | 22288485 |
| [aggregatibacter actinomycetemcomitans]. | | 2011 | 22286682 |
| characterization of aggregatibacter actinomycetemcomitans strains in periodontitis patients in germany. | aggregatibacter actinomycetemcomitans strains of serotype b and with a deletion of 530 bp in the promoter region of the leukotoxin gene (jp2 clone) are known to be associated with severe periodontitis. our study was aimed to detect virulence genes of a. actinomycetemcomitans strains obtained from patients living in four german cities with different proportions of immigrants. | 2012 | 22246112 |
| release of metronidazole from electrospun poly(l-lactide-co-d/l-lactide) fibers for local periodontitis treatment. | we aimed to achieve detailed biomaterials characterization of a drug delivery system for local periodontitis treatment based on electrospun metronidazole-loaded resorbable polylactide (pla) fibers. | 2012 | 22226009 |
| investigation and quantification of key periodontal pathogens in patients with type 2 diabetes. | diabetes is a recognized risk factor for periodontitis. there are conflicting data regarding whether healthy diabetic patients or diabetic patients with chronic periodontitis have an altered subgingival microbiota compared with nondiabetic individuals. the aim of the present study was to detect quantitative differences in selected periodontopathogens in the subgingival plaque of diabetic patients using taqman quantitative pcr. | 2012 | 22220967 |
| adhesion of aggregatibacter actinomycetemcomitans and fusobacterium nucleatum on bioactive tio(2) surfaces. | bioactive tio(2) coatings have been found to enhance fibroblast adhesion and gingival attachment on the titanium surfaces, but no information is available whether the coatings also promote the adhesion of periodontal pathogens. | 2013 | 22220677 |
| a case of aggregatibacter actinomycetemcomitans endocarditis presenting as quadriceps myositis. | an 80 year old female was admitted with an eight week history of fever associated with painful swelling of her right thigh, and a long history of poor dentition. culture of blood stained fluid aspirated from the abscess grew aggregatibacter actinomycetemcomitans (aa) sensitive to ampicillin and cephalosporins. transoesophageal echocardiography indicated endocarditis. four weeks treatment with intravenous ceftriaxone and appropriate dental care was followed by full recovery. | 2012 | 24470921 |
| bactericidal effects of a high-power, red light-emitting diode on two periodontopathic bacteria in antimicrobial photodynamic therapy in vitro. | light-emitting diodes have been investigated as new light activators for photodynamic therapy. we investigated the bactericidal effects of high-power, red light-emitting diodes on two periodontopathic bacteria in vitro. | 2011 | 25426898 |
| bacterial leakage in implants with different implant-abutment connections: an in vitro study. | two-piece implants present gaps and cavities between the implant and the abutment, and these hollow spaces can act as a trap for bacteria. the aim of the present in vitro study was to evaluate the migration of two different microbial species from the inside to the outside of the implant-abutment assembly in three different connection types. | 2012 | 21780904 |
| in vitro antibacterial efficacy of cetylpyridinium chloride-containing mouthwashes. | the objective of this study was to examine the ability of three cpc-containing mouthwashes to kill planktonic bacteria in an in vitro short-exposure assay. | 2011 | 22403973 |
| clinical case report on treatment of generalized aggressive periodontitis. | the purpose of this study was to evaluate the improvement of periodontal health of generalized aggressive periodontitis (gagp) diagnosed patients treated with non-surgical periodontal therapy accompanying systemic antibiotics administration. | 2010 | 21072223 |
| detection rates of presumptive periodontal pathogens in subgingival plaque samples of untreated periodontitis using either four or six pooled samples. | a comparison of the detection frequency and number of periodontal pathogens in patients with aggressive or generalized, severe chronic periodontitis using a gene-probe analysis. | 2010 | 25427269 |
| antibacterial activity of polysaccharide gel extract from fruit rinds of durio zibethinus murr. against oral pathogenic bacteria. | the polysaccharide gel (pg) extract from durian fruit rinds (durio zibethinus murr. "monthong") is a pectic polysaccharide with antibacterial activity. this study aimed to investigate the in vitro antibacterial activity of pg against oral pathogens, streptococcus mutans (s.mutans) and aggregatibacter actinomycetemcomitans (a.actinomycetemcomitans). | 2010 | 25427268 |
| aggregatibacter actinomycetemcomitans arcb influences hydrophobic properties, biofilm formation and adhesion to hydroxyapatite. | the regulation of gene expression in the oral pathogen aggregatibacter actinomycetemcomitans is still not fully elucidated. arcab is a two-component system which allows facultative anaerobic bacteria to sense various respiratory growth conditions and adapt their gene expression accordingly.this study investigated in a. actinomycetemcomitans the role of arcb on the regulation of biofilm formation, adhesion to saliva coated hydroxyapatite (sha) and the hydrophobic properties of the cell. these phe ... | 2009 | 24031399 |
| recovery of putative pathogens from paper point sampling at different depths of periodontal lesions. | the aim of this study was to compare the recovery of three putative periodontal pathogens from periodontal lesions in samples using paper points inserted to different depths of the lesions. | 2009 | 23674898 |
| staphylococcus epidermidis biofilms: functional molecules, relation to virulence, and vaccine potential. | medical device-associated infections, most frequently caused by staphylococcus epidermidis and staphylococcus aureus, are of increasing importance in modern medicine. the formation of adherent, multilayered bacterial biofilms is crucial in the pathogenesis of these infections. polysaccharide intercellular adhesin (pia), a homoglycan of β-1,6-linked 2-acetamido-2-deoxy-d: -glucopyranosyl residues, of which about 15% are non-n-acetylated, is central to biofilm accumulation in staphylococci. it tra ... | 2009 | 22328030 |
| distribution of biotypes and leukotoxic activity of aggregatibacter actinomycetemcomitans isolated from brazilian patients with chronic periodontitis. | aggregatibacter actinomycetemcomitans is an important etiologic agent of the periodontitis and is associated with extra-oral infections. in this study, the detection of the ltxa gene as well as the ltx promoter region from leukotoxic a. actinomycetemcomitans isolated from 50 brazilian patients with periodontitis and 50 healthy subjects was performed. the leukotoxic activity on hl-60 cells was also evaluated. leukotoxic activity was determined using a trypan blue exclusion method. the 530 bp dele ... | 2008 | 24031284 |
| common polymorphisms in the ifi16 and aim2 genes are associated with periodontal disease. | we investigated the single nucleotide polymorphism (snp) context of a previously identified periodontitis-associated locus and examined its association with microbial, biological and periodontal disease clinical parameters. | 2017 | 28387608 |
| incidence of inflammatory joint diseases in finland: results from a population-based epidemiological study. | the objective of the study was to assess the incidence of inflammatory joint diseases and possible environmental factors contributing to their occurrence in a defined population in finland. all rheumatologists practising in the northern savo rheumatological outpatient departments collected data on their newly diagnosed patients with an inflammatory joint disease in 2010. antibodies to aggregatibacter actinomycetemcomitans (aa) and porphyromonas gingivalis (pg) were determined from patients with ... | 2017 | 28791449 |
| pro-inflammatory cytokine responses in human gingival epithelial cells after stimulation with cell wall extract of aggregatibacter actinomycetemcomitans subtypes. | varying cytokine responses of human gingival epithelial cells (hgecs) by aggregatibacter actinomycetemcomitans subtypes have been found. most studies have used reference strains, whereas a few has evaluated the cytokine expression in response to clinical subtypes of this bacterial species. this study aimed to examine whether there was any difference in cytokine responses of hgecs stimulated with cell wall extract (cwe) from a. actinomycetemcomitans subtypes included clinical strains from thai ad ... | 2017 | 28780429 |
| prevalence of periodontal pathogens among italian patients with chronic periodontitis: a retrospective study on 2992 patients. | the aim of the present study was to evaluate the prevalence of some periodontal pathogens in italian adults with chronic periodontitis. | 2017 | 28757933 |
| do quaternary ammonium monomers induce drug resistance in cariogenic, endodontic and periodontal bacterial species? | antibacterial monomers were developed to combat oral biofilm acids and caries; however, little is known on whether quaternary ammonium monomers (qams) would induce drug resistance in oral bacteria. the objective of this study was to investigate the effects of new antimicrobial monomers dimethylaminohexadecyl methacrylate (dmahdm) and dimethylaminododecyl methacrylate (dmaddm) on the induction of drug resistance in eight species of cariogenic, endodontic and periodontal bacteria for the first tim ... | 2017 | 28755761 |
| age-related prevalence and characteristics of aggregatibacter actinomycetemcomitans in periodontitis patients living in sweden. | background: the presence of aggregatibacter actinomycetemcomitans in patients with periodontitis has been extensively studied for decades. objective: to study the prevalence of a. actinomycetemcomitans in younger and older periodontitis patients and to genetically characterize isolates of this bacterium. design: data from microbiological analyses of 3459 subgingival plaque samples collected from 1445 patients, 337 'younger' patients (≤35 yrs) and 1108 'older' patients (>35 yrs) during 15 years ( ... | 2017 | 28748039 |
| prevalence of periodontal pathogens in a group of participants from the middle east and north africa geographic region with minimal periodontal disease. | to assess the prevalence of the three putative periodontal pathogens such as aggregatibacter actinomycetemcomitans (a. a), porphyromonas gingivalis (p. g), and prevotella intermedia (p. i) in a group of arab participants from the middle east and north africa (mena) region who had minimal periodontal disease and no history of periodontal treatment and further to analyze the association among these three microorganisms. | 2017 | 28713765 |
| prevalence and comparative analysis of the type iv secretion system in aggregatibacter actinomycetemcomitan. | aggregatibacter actinomycetemcomitans has emerged as one of the aetiological agents in periodontal disease. although type iv secretion systems (t4sss) are widely distributed in many bacteria, the genetic features and distribution of t4sss in a. actinomycetemcomitans remain unclear. in this study, we investigated the prevalence of a. actinomycetemcomitans serotypes and their t4sss in a taiwanese population. | 2017 | 28711435 |
| aggregatibacter actinomycetemcomitans growth in biofilm versus planktonic state: differential expression of proteins. | aggregatibacter actinomycetemcomitans (aa) is a pathogenic bacterium residing in the subgingival plaque biofilm strongly associated with the pathogenesis of periodontitis. the aim of this investigation was to study the protein differential expression of aa when growing on biofilm compared with planktonic state using proteomic analysis by the 2d-dige system. eighty-seven proteins were differentially expressed during biofilm growth (1.5-fold, p < 0.05), with 13 overexpressed and 37 down-expressed. ... | 2017 | 28707473 |
| the association of periodontopathic bacteria levels
in saliva and tongue coating with oral malodor in periodontitis patients. | to elucidate the association oral malodor with the levels of periodontopathic bacteria in saliva and tongue coating of periodontitis patients with oral malodor. | 2017 | 28674708 |
| chronic periodontal disease, periodontal pathogen colonization, and an increased risk of precancerous gastric lesions. | the present study assessed the association between periodontal pathogen colonization and the potential risk of developing precancerous lesions of gastric cancer (plgc) in a clinical setting. | 2017 | 28671506 |
| aggregatibacter actinomycetemcomitans serotype prevalence and antibiotic resistance in a uk population with periodontitis. | aggregatibacter actinomycetemcomitans is a recognised pathogen involved in aggressive periodontitis. seven serotypes of a. actinomycetemcomitans exist with a range of virulence and distribution dependent on ethnicity and geography. the ability of a. actinomycetemcomitans to invade soft tissue can necessitate the use of systemic antibiotics for treatment, however variations in its antibiotic susceptibility exist dependent on geographical location. | 2017 | 28668698 |
| characterization and serotype distribution of aggregatibacter actinomycetemcomitans: relationship of serotypes to herpesvirus and periodontal status in indian subjects. | the virulence of aggregatibacter actinomycetemcomitans (a. actinomycetemcomitans) in any individual depends on the type of strain of this bacterium. to our knowledge, there have been no studies reported in indian subjects about a. actinomycetemcomitans serotype occurrence, co-existence with herpes virus and the possible influence of such co-existence on periodontal pathology. | 2017 | 28668607 |
| effects of photodynamic therapy in periodontal treatment: a randomized, controlled clinical trial. | to evaluate the effects of photodynamic therapy (pdt) in the nonsurgical treatment of chronic periodontitis. | 2017 | 28667678 |
| natural monoclonal antibody to oxidized low-density lipoprotein and aggregatibacter actinomycetemcomitans. | natural antibodies are produced by b lymphocytes without exogenous antigenic exposure and are present at the time of birth. they usually bind to conserved epitopes on antigens of different chemical compositions. we cloned and characterized a natural mouse monoclonal igm antibody (aa_mab) by selecting the binding to malondialdehyde acetaldehyde (maa) adducts on low-density lipoprotein (ldl). the data showed that the aa_mab cross-reacted with aggregatibacter actinomycetemcomitans (aa) bacteria, an ... | 2017 | 28667536 |
| stimulatory effect of aggregatibacter actinomycetemcomitans dna on proinflammatory cytokine expression by human gingival fibroblasts. | while different virulence factors have been reported of aggregatibacter actinomycetemcomitans (aa), there is little information about the stimulatory effect of its dna. the main purpose of this study was to assess the inflammatory response of human gingival fibroblasts (hgfs) stimulated with a. actinomycetemcomitans dna. | 2017 | 28641178 |
| is aggregatibacter actinomycetemcomitans the missing link between periodontitis and rheumatoid arthritis? | | 2017 | 28632321 |
| lactobacillus salivarius nk02: a potent probiotic for clinical application in mouthwash. | a specific strain of naturally occurring oral lactobacilli was isolated and identified based on morphological, biochemical, and 16s rrna gene sequencing. the phylogenetic affiliation of the isolate confirmed that the nk02 strain had close association with the lactobacillus salivarius. an effective mouthwash was developed for treatment of periodontitis and suppression of the indicator bacterium aggregatibacter actinomycetemcomitans which is an obvious pathogen of periodontal disease. the mouthwas ... | 2017 | 28631250 |
| mikania glomerata sprengel extract and its major compound ent-kaurenoic acid display activity against bacteria present in endodontic infections. | the search for new, effective and safe antimicrobial compounds from plant sources has continued to play an important role in the maintenance of human health since ancient times. such compounds can be used to help to eradicate microorganisms from the root canal system, preventing/healing periapical diseases. mikania glomerata (spreng.), commonly known as "guaco," is a native climbing plant from brazil that displays a wide range of pharmacological properties. many of its activities have been attri ... | 2017 | 28627377 |
| aggregatibacter actinomycetemcomitans regulates the expression of integrins and reduces cell adhesion via integrin α5 in human gingival epithelial cells. | gingival epithelial cells form a physiological barrier against bacterial invasion. excessive bacterial invasion destroys the attachment between the tooth surface and the epithelium, resulting in periodontitis. integrins play a significant role in cell attachment; therefore, we hypothesized that bacterial infection might decrease the expressions of these integrins in gingival epithelial cells, resulting in reduced cell adhesion. immortalized human gingival epithelial cells were co-cultured with a ... | 2017 | 28593565 |
| the microbial changes in subgingival plaques of orthodontic patients: a systematic review and meta-analysis of clinical trials. | orthodontic treatment was found to have an impact on the quantity and constitution of subgingival microbiota. however, contradictory findings regarding the effects of fixed appliances on microbial changes were reported. the aim of this systematic review was to investigate the microbial changes in subgingival plaques of orthodontic patients. | 2017 | 28576147 |
| ag nanoparticle-coated zirconia for antibacterial prosthesis. | bacterial adhesion to dental materials is a major cause of caries and periodontitis, necessitating the development of compounds such as yttria-stabilized zirconia (ysz) and silver nanoparticles (agnps), which are widely employed in medicine due to their high antimicrobial activity and low cytotoxicity. the main goal of this study is the synthesis of the broad antimicrobial activity of agnp-coated ysz with facile methods. the bactericidal agnps were immobilized on the surface of ysz and tested fo ... | 2017 | 28575940 |
| the role of 5-lipoxygenase in aggregatibacter actinomycetemcomitans-induced alveolar bone loss. | leukotrienes (lts) are pro-inflammatory lipid mediators formed by the enzyme 5-lipoxygenase (5-lo). the involvement of 5-lo metabolites in periodontal disease (pd) is not well defined. this study aimed to assess the role of 5-lo in experimental pd induced by aggregatibacter actinomycetemcomitans (aa). | 2017 | 28569991 |
| role of de-n-acetylase pgab from aggregatibacter actinomycetemcomitans in exopolysaccharide export in biofilm mode of growth. | aggregatibacter actinomycetemcomitans, a gram-negative bacterium, is the causative agent of localized aggressive periodontitis. attachment to a biotic surface is a critical first step in the a. actinomycetemcomitans infection process for which exopolysaccharides have been shown to be essential. in addition, the pga operon, containing genes encoding for biosynthetic proteins for poly-n-acetyl glucosamine (pnag), plays a key role in a. actinomycetemcomitans virulence, as a mutant strain lacking th ... | 2017 | 28548373 |
| cross-reactive saliva iga antibodies to oxidized ldl and periodontal pathogens in humans. | oxidized low-density lipoproteins (oxldl) are formed as a result of lipid peroxidation and are highly immunogenic and proatherogenic. in this study, saliva antibodies binding to oxldl, porphyromonas gingivalis (pg) and aggregatibacter actinomycetemcomitans (aa) were characterized and their cross-reactivity was evaluated. | 2017 | 28548243 |
| the in vivo t helper type 17 and regulatory t cell immune responses to aggregatibacter actinomycetemcomitans. | the periodontal pathogen aggregatibacter actinomycetemcomitans is known to elicit a systemic immune response in the infected host, and occasionally causes non-oral infections. detailed information on its immunopathological responses and the involvement of bacterial virulence factors remains to be elucidated. the aim of this study was to assess the systemic immune response to a. actinomycetemcomitans oral infection. we used an animal model that simulates systemic dissemination of the bacteria by ... | 2017 | 28544588 |
| herpes simplex 1 and periopathogen role in peri-implantitis. | the objectives of this study were to compare the qualitative and quantitative profiles of herpes simplex virus type i (hsv-1) in implant surfaces between participants with peri-implantitis (pi) and healthy peri-implant tissues and to quantitatively assess the relation between hsv-1 and periopathogens inside the microbiological profile associated with pi. | 2017 | 28512280 |
| increased leukotoxin production: characterization of 100 base pairs within the 530 base pair leukotoxin promoter region of aggregatibacter actinomycetemcomitans. | aggregatibacter actinomycetemcomitans leukotoxin (ltxa) is a major virulence factor that kills leukocytes permitting it's escape from host immune surveillance. a. actinomycetemcomitans strains can produce high or low levels of toxin. genetic differences reside in the "so called jp2" ltxa promoter region. these hyper-leukotoxin producing strains with the 530 bp deletion have been studied in detail. however, regions contained within the 530 bp deletion that could be responsible for modulation of l ... | 2017 | 28507341 |
| putative periodontal pathogens in the subgingival plaque of sudanese subjects with aggressive periodontitis. | there has been limited study of the bacterial species associated with aggressive periodontitis (agp) in high-risk populations in africa. the aim of this study was to investigate and quantify the presence of four putative periodontal pathogens in the subgingival plaque of sudanese subjects with agp. a secondary aim was to investigate the effect of varying the detection threshold on the reported prevalence of the bacterial species investigated. | 2017 | 28499236 |
| investigations of a possible chemical effect of salvadora persica chewing sticks. | salvadora persica is commonly used chewing sticks in many parts of the world as an oral hygiene tool. this study measured the amount of benzyl isothiocyanate (bitc) released into the mouth and assessed its retention time in saliva. the study also tested if the released amount of bitc could potentially be antibacterial or cytotoxic. twelve subjects brushed their teeth with fresh miswak once, twice, and four times. the amount of bitc in the saliva and in the used brushes was quantified using gas c ... | 2017 | 28484501 |
| some gram-negative lipoproteins keep their surface topology when transplanted from one species to another and deliver foreign polypeptides to the bacterial surface. | in gram-negative bacteria, outer membrane-associated lipoproteins can either face the periplasm or protrude out of the bacterial surface. the mechanisms involved in lipoprotein transport through the outer membrane are not fully elucidated. some lipoproteins reach the surface by using species-specific transport machinery. by contrast, a still poorly characterized group of lipoproteins appears to always cross the outer membrane, even when transplanted from one organism to another. to investigate s ... | 2017 | 28483926 |
| defining genetic fitness determinants and creating genomic resources for an oral pathogen. | periodontitis is a microbial infection that destroys the structures that support the teeth. although it is typically a chronic condition, rapidly progressing, aggressive forms are associated with the oral pathogen aggregatibacter actinomycetemcomitans one of this bacterium's key virulence traits is its ability to attach to surfaces and form robust biofilms that resist killing by the host and antibiotics. though much has been learned about a. actinomycetemcomitans since its initial discovery, we ... | 2017 | 28476775 |
| monitoring gene expression of rcpa from aggregatibacter actinomycetemcomitans versus antimicrobial photodynamic therapy by relative quantitative real-time pcr. | aggregatibacter actinomycetemcomitans is an important pathogen that is frequently found in various infections, particularly aggressive periodontitis. in this study, we described the outcome of the expression level of a. actinomycetemcomitans virulence factor following treatment by antimicrobial photodynamic therapy (apdt) with indocyanine green (icg) as a photosensitizing agent. | 2017 | 28450261 |
| antimicrobial photodynamic activity and cytocompatibility of au25(capt)18 clusters photoexcited by blue led light irradiation. | antimicrobial photodynamic therapy (apdt) has beneficial effects in dental treatment. we applied captopril-protected gold (au25(capt)18) clusters as a novel photosensitizer for apdt. photoexcited au clusters under light irradiation generated singlet oxygen ((1)o2). accordingly, the antimicrobial and cytotoxic effects of au25(capt)18 clusters under dental blue light-emitting diode (led) irradiation were evaluated. (1)o2 generation of au25(capt)18 clusters under blue led irradiation (420-460 nm) w ... | 2017 | 28435253 |
| aggregatibacter actinomycetemcomitans pneumonia with chest and abdominal wall involvement. | a 54-year-old man presented with a productive cough, chest pain, fever and weight loss. initial analysis revealed a palpable chest wall mass and consolidation in the left lower lobe and pleural abnormalities on imaging. at that point no infectious cause or malignancy was identified. microbiological analysis of a needle biopsy from a newly developed abdominal wall mass revealed growth of aggregatibacter actinomycetemcomitans the patient was successfully treated with antibiotic therapy for 1 year. ... | 2017 | 28432161 |
| photo-activated elimination of aggregatibacter actinomycetemcomitans in planktonic culture: comparison of photodynamic therapy versus photothermal therapy method. | periodontal pathogens are the main factors responsible for periodontal diseases and considering the limitations of conventional mechanical debridement, new treatment approaches are under investigation. this study was designed to evaluate and compare the antibacterial effects of two different systems of photodynamic and photothermal therapy on aggregatibacter actinomycetemcomitans as the main pathogen involved in aggressive periodontitis. | 2017 | 28414081 |
| in vitro antimicrobial activity of thymus vulgaris essential oil against major oral pathogens. | the objective of present investigation was to determine antimicrobial activity of thymus vulgaris oil on some oral pathogens. thymus vulgaris oil was prepared by hydrodistillation and tested against 30 clinical isolates of each of streptococcus pyogenes, streptococcus mutans, candida albicans, porphyromonas gingivalis, and aggregatibacter actinomycetemcomitans, prepared from related oral infections using agar disk diffusion and broth microdilution methods. thymus vulgaris oil at concentrations o ... | 2017 | 28397552 |
| the cage gene sequence as a diagnostic marker to identify jp2 and non-jp2 highly leukotoxic aggregatibacter actinomycetemcomitans serotype b strains. | aggregatibacter actinomycetemcomitans is involved in oral and systemic infections, and is associated with, eg aggressive forms of periodontitis and with endocarditis. the cage gene encodes a ≈39 kda putative exotoxin expressed by a. actinomycetemcomitans. the level of conservation of cage, and its possible significance in periodontal disease, has not yet been thoroughly investigated. in the present study, the role of the cage gene as a diagnostic marker has been investigated. | 2017 | 28397250 |
| porphyromonas gingivalis antibody levels and diagnosis of coronary artery disease in hiv-positive individuals. | periodontal disease has been associated with cardiovascular disease in the general population. it is unknown whether igg antibody levels for periodontal pathogens are associated with the diagnosis of coronary artery disease (cad) in hiv-positive individuals. | 2017 | 28397248 |
| soluble epoxide hydrolase pharmacological inhibition decreases alveolar bone loss by modulating host inflammatory response, rank-related signaling, endoplasmic reticulum stress, and apoptosis. | epoxyeicosatrienoic acids (eets), metabolites of arachidonic acid derived from the cytochrome p450 enzymes, are mainly metabolized by soluble epoxide hydrolase (seh) to their corresponding diols. eets but not their diols, have anti-inflammatory properties, and inhibition of seh might provide protective effects against inflammatory bone loss. thus, in the present study, we tested the selective seh inhibitor, 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (tppu), in a mouse model of p ... | 2017 | 28356494 |
| antimicrobial effects of mastic extract against oral and periodontal pathogens. | various antimicrobial agents are widely used in the therapy of oral inflammatory diseases. however, their side effects and the appearance of drug resistance justify research on natural antimicrobial agents to target oral pathogens that are safe for the host. in the present study, antimicrobial properties of mastic extract on commensal and pathogenic oral bacteria, as well as its possible cytotoxic effect toward cells of epithelial and mesenchymal origin, were evaluated and compared with the comm ... | 2017 | 28067105 |
| antimicrobial activities of stearidonic and gamma-linolenic acids from the green seaweed enteromorpha linza against several oral pathogenic bacteria. | we found that the edible green seaweed enteromorpha linza displayed potent antimicrobial activity against prevotella intermedia and porphyromonas gingivalis. to elucidate the active component of e. linza, isolation procedures were performed. | 2013 | 28510876 |
| risk of superinfection in peri-implantitis after systemic broad spectrum antibiotics. | peri-implant disease has developed over the last few years as a complication that is often difficult to resolve. the disease process is mainly attributed to bacterial infection. proposed combined therapies use broad-spectrum antibiotics to halt its progression. a major associated risk is the undetected development of superinfections that are difficult to eradicate. a group of healthy individuals with advanced peri-implantitis (pi) were referred for evaluation due to severe, rapidly progressive b ... | 2017 | 28854287 |
| quantification by qpcr of pathobionts in chronic periodontitis: development of predictive models of disease severity at site-specific level. | currently, there is little evidence available on the development of predictive models for the diagnosis or prognosis of chronic periodontitis based on the qpcr quantification of subgingival pathobionts. our objectives were to: (1) analyze and internally validate pathobiont-based models that could be used to distinguish different periodontal conditions at site-specific level within the same patient with chronic periodontitis; (2) develop nomograms derived from predictive models. subgingival plaqu ... | 2017 | 28848499 |
| microbiological response to periodontal therapy and multivariable prediction of clinical outcome. | this study assessed the microbiological effects of a 2-phase antimicrobial periodontal therapy and tested microbiological, clinical, and biological markers as prognostic indicators for clinical success. | 2017 | 28844191 |
| killing activity of lfchimera on periodontopathic bacteria and multispecies oral biofilm formation in vitro. | lactoferrin chimera (lfchimera), a heterodimeric peptide containing lactoferrampin (lfampin265-284) and a part of lactoferricin (lfcin17-30), possesses a broad spectrum of antimicrobial activity. however, there is no report on the inhibitory effects of lfchimera against multispecies oral biofilms. this study aimed to determine the effects of lfchimera in comparison to chlorhexidine digluconate (chx) and minocycline hydrochloride (mh), on in vitro multispecies biofilms derived from subgingival pl ... | 2017 | 28823045 |
| non-surgical therapy reduces presence of jp2 clone in localized aggressive periodontitis. | previous studies have provided substantial evidence on the association of aggregatibacter actinomycetemcomitans (aa), and its highly leukotoxic jp2 genotype, with localized aggressive periodontitis (lap). the present study aims to evaluate the presence of jp2 in lap individuals following periodontal treatment. | 2017 | 28820321 |
| specific periodontopathic bacterial infection affects hypertension in male cardiovascular disease patients. | hypertension (ht) is a systemic disorder that results in the decline of quality of life and death. while patients with periodontitis are at a high risk of ht, little causal information has been provided to date. to clarify the relationship, periodontopathic bacterial infection in cardiovascular patients with or without ht was evaluated. the subjects were patients with (n = 412) or without (n = 199) ht who attended tokyo medical and dental university hospital. blood examinations and periodontal m ... | 2017 | 28803419 |