Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| the feasibility of an assistant to the physician. | 2014 | 4152241 | |
| the purification of portuguese man-of-war nematocyst toxins by gel diffusion. | 1973 | 4150989 | |
| letter: lipolysis induced by coffee and tobacco: its modification by insulin. | 1973 | 4148444 | |
| letter: brain-levels of monoamine oxidase in depression. | 2014 | 4136104 | |
| [prostatectomy and amputatio recti]. | 2014 | 4103378 | |
| distribution and elimination of [14c]-hexachlorobenzene after single oral exposure in cod (gadus morhua) and flounder (platichthys flesus). | distribution and elimination of hexachlorobenzene (hcb) after administration to cod (gadus morhua) of a single oral dose of 5 microci [14c]hcb/100 g body weight were studied by whole-body autoradiography and liquid scintillation counting. to obtain some information on the physicochemical properties of the radiolabeled compounds, whole-body autoradiography was performed exposing parallel sagittal sections, treated at -20 degrees c, evaporated at 50 degrees c, and extracted separately with polar a ... | 2014 | 4078931 |
| [factors determining the severity of traumatic lesions of the popliteal artery]. | 2013 | 4073583 | |
| [organization of the regular schedules of forensic-medical experts at a bureau of forensic medical examinations]. | 2014 | 4071589 | |
| the distribution of lactate dehydrogenase isoenzymes in adult human achilles tendons. | the authors have studied the ldh isoenzymes distribution in the human achilles tendons. connection between the age, sex, and enzyme activity were not found. in the achilles tendon were found strong activity of isoenzymes iv and v (m-type), and controversy them moderate activity of isoenzymes i and ii (h-type). | 1985 | 4065385 |
| local cerebral glucose utilization in normal female rats: variations during the estrous cycle and comparison with males. | the quantitative 2-[14c]deoxyglucose autoradiographic method was used to study the fluctuations of energy metabolism in discrete brain regions of female rats during the estrous cycle. a consistent though statistically nonsignificant cyclic variation in average glucose utilization of the brain as a whole was observed. highest levels of glucose utilization occurred during proestrus and metestrus, whereas lower rates were found during estrus and diestrus. statistically significant fluctuations were ... | 1985 | 4040921 |
| repeatability of phasic muscle activity: performance of surface and intramuscular wire electrodes in gait analysis. | repeatability is an important consideration for gait analysis data that are being used as an adjunct to clinical decision making. an index of repeatability may be based on a statistical criterion (variance ratio) that reflects similarity of wave forms over a number of identical cycles. the purpose of this study was to use the variance ratio to assess the repeatability of phasic muscle activity recorded with surface and bipolar intramuscular wire electrodes during gait on 10 normal subjects. vari ... | 2013 | 4032106 |
| [in vitro fertilization in reduced male fertility]. | 2013 | 4029742 | |
| noninvasively diagnosed peripheral arterial disease as a predictor of mortality: results from a prospective study. | intermittent claudication has been reported in previous studies to approximately double the risk of subsequent mortality. however, a history of claudication is often present in the absence of significant peripheral arterial disease (pad) and absent in the presence of pad. for this reason we evaluated the association between large-vessel and small-vessel pad, measured by highly reliable and valid noninvasive tests, and mortality in 567 older subjects from a defined population followed-up for an a ... | 2014 | 4028377 |
| [persistent chlamydia infection in cell culture]. | 1985 | 3993192 | |
| blood transfusion and athletics. games people play. | 2014 | 3974666 | |
| torsade de pointes: a maximal vulnerability arrhythmia. | 2014 | 3966319 | |
| velopharyngeal insufficiency in children: the variable clinical presentation. | 2014 | 3957645 | |
| growth hormone modulates serum cholinesterase. | adult male rats have lower serum cholinesterase activity levels than adult female rats and hypophysectomized male rats have higher activity levels than sham-operated males (similar to control females). gh administered to hypophysectomized male rats abolishes the effect of hypophysectomy on serum cholinesterase. adult male rats treated neonatally with monosodium l-glutamate to induce arcuate nucleus lesions of the hypothalamus have higher serum cholinesterase activities and decreased serum gh con ... | 1986 | 3948777 |
| overdose with baclofen. | 2014 | 3945841 | |
| family history of cancer among cancer patients. | family history of cancer was examined for 9,131 cancer patients who were reported to the aichi cancer registry in 1979-1981, and were over 20 years old at diagnosis. the rate of patients whose parents and/or siblings had cancer of any site was 24.5%. the rate was 9.2% for father, 8.4% for mother, 6.0% for brother(s), and 5.2% for sister(s). a significant site concordance between study patient and family member with cancer was observed for cancer of the breast, colon and rectum, and stomach. the ... | 2014 | 3920100 |
| viruses and immune reactions in the liver. | the immunopathology of hepatitis b and delta virus infections of the liver are reviewed. it is clear there are several antigen/antibody systems of importance in acute and chronic hbv infection. antibodies to hbs, hb core/hbe and antibodies to dane specific determinants are involved in virus neutralisation. elimination of virus infected hepatocytes is dependent on recognition of viral determinants in association with hla proteins on the infected hepatocytes by cytotoxic t cells. the hla protein d ... | 1985 | 3911368 |
| [conservative treatment of injuries of the liver]. | 2014 | 3911104 | |
| 1h-15n heteronuclear nmr studies of escherichia coli thioredoxin in samples isotopically labeled by residue type. | ten samples of escherichia coli thioredoxin were individually isotopically enriched by residue type via growth of an appropriate auxotrophic strain on media supplemented with one 2h, 15n-enriched amino acid. 1h observe-heteronuclear decoupling experiments were conducted on these samples making use of the 95-hz 1h-15n amide j1 coupling. subtraction of near-resonance from off-resonance 15n decoupled spectra generated difference patterns corresponding only to protons directly bonded to 15n nuclei. ... | 1985 | 3910099 |
| physiology of the upper airways in allergic disease. | 2014 | 3902190 | |
| isolation and characterization of neuropeptide y from porcine intestine. | the isolation and primary structure of intestinal neuropeptide y (npy) is described. the peptide was purified from porcine intestinal extracts using a chemical assay and radioimmunoassay for npy. the amino acid sequence of this peptide is: tyr-pro-ser-lys-pro-asp-asn-pro-gly-glu-asp-ala-pro-ala-glu-asp-leu-ala- arg-tyr-tyr- ser-ala-leu-arg-his-tyr-ile-asn-leu-ile-thr-arg-gln-arg-tyr-nh2. this the structure of intestinal npy is identical to the npy of brain origin. | 1985 | 3838090 |
| [pacemaker implantation in infants and children for atrioventricular block]. | 2014 | 3819491 | |
| cervical lymph node metastases with occult primary. | patients with cervical metastases from an unknown primary tumour present both diagnostic and therapeutic problems. twenty patients with a metastatic lesion in the neck, in whom the primary tumour was not found despite extensive, diagnostic procedures, were treated in the department of otolaryngology, linköping university hospital, during a 14-year period (1971-1984). since 1975 tonsillectomy has been performed regularly on the affected side as a part of the diagnostic procedure. eight patients w ... | 2012 | 3815873 |
| interference of bromide in determination of serum chloride. | 2010 | 3815810 | |
| meta-analyses of randomized controlled trials. | a new type of research, termed meta-analysis, attempts to analyze and combine the results of previous reports. we found 86 meta-analyses of reports of randomized controlled trials in the english-language literature. we evaluated the quality of these meta-analyses, using a scoring method that considered 23 items in six major areas--study design, combinability, control of bias, statistical analysis, sensitivity analysis, and application of results. only 24 meta-analyses (28 percent) addressed all ... | 2013 | 3807986 |
| the role of the paediatric endoscopist. | the role of the paediatric endoscopist has been a changing one. when i first commenced at the royal alexandra hospital for children in sydney 25 years ago, paediatric endoscopy of the upper respiratory tract and oesophagus was a limited and poorly defined field. most endoscopic examinations were requested, often reluctantly, by a paediatrician in the investigation of stridor. in fact my first consultation involved instructions to perform a laryngoscopy, but not a bronchoscopy and general anaesth ... | 2013 | 3805880 |
| local anaesthetics. iv--synthesis and activity of 2-(n-substituted or n,n-disubstituted aminoacetamido)-4- or -4,5-substituted thiazoles. | synthesis is described of eleven new 2-(n-substituted or n,n-disubstituted aminoacetamido)-4- or -4,5-substituted thiazoles (i). their hydrochlorides were screened for local anaesthetic activity on frogs by the sciatic plexus method and the activity compared with that of procaine. | 2013 | 3792539 |
| antibiotic resistance patterns of vibrio mimicus isolated from human and environmental sources in bangladesh. | twenty-five environmental and 19 clinical strains of vibrio mimicus were tested for antibiotic susceptibility patterns. environmental strains were resistant to streptomycin, kanamycin, and trimethoprim-sulfamethoxazole; clinical strains were susceptible. environmental strains showed variable resistance to ampicillin (44%), but clinical strains were susceptible. all strains tested were susceptible to chloramphenicol and gentamicin. | 1986 | 3789697 |
| haemothorax in the course of chickenpox. | 2013 | 3787528 | |
| [pathogenesis and treatment of arterial hypertension in hypothyroidism patients]. | 2013 | 3784472 | |
| regional myocardial protection by retrograde coronary sinus infusion of cardioplegic solution. | antegrade administration of a cardioplegic solution in the presence of a coronary artery stenosis may lead to the heterogeneous distribution of the agent and poor myocardial cooling distal to a vessel stenosis. to determine the effects of retrograde coronary sinus infusion of cardioplegic solution, coronary stenosis was created in the canine preparation by occluding the left circumflex artery (lcx) during cardioplegic arrest. left ventricular global and regional function (assessed by sonomicrome ... | 1986 | 3769184 |
| change of blood pressure over five years in childhood and adolescence. | we compared blood pressure (bp) values, measured at a five year interval, in 2,777 boys and girls aged 4-18 years. bp values were converted into height and sex adjusted standard deviation unit scores. correlation coefficients were significant but low for systolic bp score: 0.19 in boys and 0.15 in girls, and were even lower for diastolic bp score. these correlations are weaker than those observed for overall bp values (boys: 0.33, girls: 0.23), weight (0.82, 0.75) and height (0.87, 0.80). the pr ... | 2013 | 3757275 |
| reference ranges and ideal patient values for blood cholesterol. can there be reconciliation? | reference ranges for blood cholesterol levels reflect the nationwide epidemic of "silent" hypercholesterolemia. as such, reference ranges for cholesterol levels without accompanying designation of levels associated with increased coronary risk are misleading and falsely comforting to physicians and patients. in a recent continent-wide study of 108 academically based clinical laboratories, highly variable reference ranges were observed, the ranges having been derived from a vast assortment of sou ... | 2013 | 3754717 |
| the binding of pirenzepine to digitonin-solubilized muscarinic acetylcholine receptors from the rat myocardium. | the binding of pirenzepine to digitonin-solubilized rat myocardial muscarinic acetylcholine receptors has been examined at 4 degrees c. solubilization produced only small changes in the binding of n-methylscopolamine and atropine. in contrast to the low affinity binding of pirenzepine found to be present in in the membranes, high affinity binding was detected in the soluble preparation. in both preparations, pirenzepine binding was complex. high affinity pirenzepine binding (kd approximately 3 x ... | 1986 | 3754173 |
| diagnosis and treatment of chalazia. | a patient with recurrent chalazia is described. this patient also had acne rosacea. the clinical and histologic characteristics of chalazia are described. in addition, therapy for chalazia is presented, with emphasis being given to conservative therapy. | 2013 | 3734179 |
| anticandidal activities of terconazole, a broad-spectrum antimycotic. | terconazole is a new triazole ketal derivative with broad-spectrum in vitro and in vivo antifungal activities. this study further characterizes the effects of terconazole in vitro on yeast cell growth, viability, and morphology. terconazole inhibited the growth of candida albicans atcc 44859 in a concentration-related manner, but with modest effects noted at levels from 10(-8) to 10(-5) m when the yeast was grown on media favoring the cell form. the inhibitory potency of terconazole on yeast cel ... | 1986 | 3729366 |
| seasonal distribution of facultatively enteropathogenic vibrios (vibrio cholerae, vibrio mimicus, vibrio parahaemolyticus) in the freshwater of the elbe river at hamburg. | between june 1981 and december 1982 the incidence of vibrio cholerae, v. mimicus and v. parahaemolyticus was determined at two sampling sites on the elbe river at hamburg. a total of 183 strains was isolated from 147 water samples. of these, 107 belonged to non-01 v. cholerae (ten strains producing a cholera-like enterotoxin); 33 were identified as v. mimicus, including two enterotoxin producers; 42 strains were kanagawa-negative cultures of v. parahaemolyticus; and one was v. fluvialis. the hig ... | 1986 | 3722029 |
| [clinical chemistry of the cerebrospinal fluid]. | 2013 | 3720593 | |
| toxin production by vibrio mimicus strains isolated from human and environmental sources in bangladesh. | vibrio mimicus has recently been isolated from aquatic environments of bangladesh. a total of 125 of 300 environmental isolates, representing various biotypes, and 19 human isolates were tested for enteropathogenicity by using several models. less than 1% of the environmental isolates and slightly more than 10% of the clinical isolates produced cholera toxin-like toxin. a significant percentage of the environmental isolates (25%) and of the human isolates (74%) induced fluid accumulation in liga ... | 1987 | 3693548 |
| toxigenicity and drug sensitivity of vibrio mimicus isolated from fresh water prawns in bangladesh. | 1986 | 3668195 | |
| na+ modulates the k+ permeability and the membrane potential of alkalophilic bacillus. | in the absence of na+ in the medium, the membrane potential of obligately alkalophilic bacillus cells was found to be decreased by the addition of k+ to the medium, whereas k+ addition in the presence of na+ had no effect. rb+ showed essentially the same effect as k+. the decreased membrane potential was quickly restored by lowering the k+ concentration in the medium or by adding na+ or li+ to the medium. thus, in the absence of na+, the membrane potential of alkalophilic bacillus seems to be af ... | 1987 | 3663674 |
| [vesico-uterine fistulas]. | 2013 | 3623249 | |
| three generations building on history. | 2013 | 3622966 | |
| temporal lobe epilepsy with schizophrenia. | i have reported a case of coexisting schizophrenia and complex partial seizures to augment earlier reports of schizophrenia and psychomotor seizures masquerading as one another. i have attempted to clarify the differential diagnosis and reinforce the need to do thorough studies in such cases. | 2013 | 3616704 |
| pentapeptide nuclear localization signal in adenovirus e1a. | the adenovirus e1a gene products are nuclear proteins important in transcriptional control of viral functions during infection. by producing normal e1a proteins and derivatives of e1a in bacteria and microinjecting these proteins into cultured cells, we were able to examine their ability to localize to the nucleus. we showed that a short peptide sequence at the carboxyl terminus of e1a is necessary for the rapid (30-min) nuclear localization of that protein. additionally, we showed that just the ... | 1987 | 3614197 |
| [acoustic indicator of membrane potential levels]. | 2013 | 3609385 | |
| incidence of vibrio cholerae from estuaries of the united states west coast. | the incidence of vibrio cholerae in shellfish, sediment, and waters of california, oregon, and washington was determined during the summer of 1984. samples from 24 distinct estuaries were analyzed qualitatively. v. cholerae non-o1 was found in 23 estuaries and in 44.6% of the 529 samples examined. v. cholerae o1 inaba was isolated from water samples in morro bay, calif. vibrio mimicus was found in 2.3% of the samples. cholera enterotoxin was not found in cell-free filtrates of the 100 isolates t ... | 1987 | 3606111 |
| recommendations for research in the epidemiology of asthma. | 2013 | 3581962 | |
| emergency room thoracotomy for stab wounds to the chest and neck. | this study group comprises 73 patients who underwent emergency room resuscitative thoracotomy for cardiac arrest following penetrating chest and neck injuries. overall, 12 patients (16.4%) were successfully resuscitated but only five (6.8%) left the hospital alive without neurologic defects. none of the 18 cases with no vital signs at all (no cardiac activity, no respiratory efforts, nonreactive pupils) on admission survived. only one out of the 19 cases with no cardiac activity and with fixed p ... | 2013 | 3573102 |
| anticoccidial activity of alborixin. | alborixin, a polyether antibiotic with ionophore properties, was evaluated to determine the effect of the drug on weight gain of chickens and to define the anticoccidial spectrum of activity. the 50-ppm concentration in the diet was identified as the maximum level that did not significantly reduce weight gain beyond that of monensin (standard drug); consequently, the drug was evaluated for anticoccidial activity at this dilution. at the 50-ppm level, alborixin demonstrated broad-spectrum anticoc ... | 1987 | 3572663 |
| the morphology and distribution of serotonin-like immunoreactive fibers in the cat dorsal column nuclei. | fibers showing serotonin-like immunoreactivity (5-ht-li) are demonstrated in the gracile, cuneate and external cuneate nuclei of the cat using avidin-biotinylated horseradish peroxidase and indirect fluorescence immunohistochemical methods. 5-ht-li fibers are located in all cytoarchitectural subdivisions of the gracile and cuneate nuclei but are restricted to the medial half of the external cuneate nucleus. in all nuclei, 5-ht-li fibers consist of long, varicose strands showing a wide range in t ... | 1987 | 3554006 |
| nocardia asteroides as a cause of corneal ulcer. case report. | 1987 | 3551895 | |
| effect of motion on the sonographic and magnetic resonance patterns of ageing blood. | the sonographic appearance of a hematoma may be affected by various factors, including the age of the hematoma. the effect of mechanical motion on the echogenicity and histologic appearance, and on the proton relaxation times t1 and t2 of blood clots, was studied in vitro for up to 21 days. all clots were of similar echogenicity and microscopic appearance during the first 2 days. the minimally disturbed clots were sonolucent from day 4 onwards, whereas moderate mechanical disturbance changed the ... | 1986 | 3535388 |
| evaluation of aerosolized triamcinolone acetonide as a replacement for aerosolized beclomethasone dipropionate. | substitution of aerosolized triamcinolone acetonide for aerosolized beclomethasone dipropionate in treatment of 30 chronic asthmatics resulted in subjective improvement in all patients. there was reduction in requirement of systemic steroids and inhaled beta adrenergics. no adrenal suppression or oropharyngeal candidiasis occurred after replacing beclomethasone dipropionate with triamcinolone acetonide. | 2012 | 3528120 |
| trimethoprim used for selective decontamination of the digestive tract in rats: possible route of excretion. | selective elimination of enterobacteriaceae species from the digestive tract of rats has been accomplished by oral treatment with trimethoprim (235 mg/kg body weight/day) within 6 days. in the present study it was investigated whether this elimination was mainly due to antimicrobial activity of trimethoprim excreted with the gastrointestinal mucus or mainly by non-absorbed trimethoprim in the lumen contents. by means of whole gut irrigation (wgi) the lumen contents were washed out, followed by m ... | 1987 | 3497436 |
| [studies on the blood constituents of the neonates delivered by the induced delivery of the defense medical college method]. | for the assessment of the influence of the defense medical college planned delivery method upon neonates, the measurement of the blood constituents of the umbilical cord was conducted. statistically speaking, no marked differences were seen between the neonates delivered by the defense medical college method and neonates delivered naturally. the blood constituents investigated were: blood cells, activity of various enzymes, other blood constituents and electrolytes. | 2012 | 3457089 |
| agoraphobia and parental bereavement. | the prevalence of parental bereavement was determined in 50 married female outpatients with a dsm-iii diagnosis of agoraphobia and in a control group of married female outpatients diagnosed as having non-psychotic psychiatric disorders other than agoraphobia. the two groups were matched for age and overall severity of psychiatric symptoms. compared with the general population, the patient control group reported a statistically significant excess of parental, but not maternal, bereavement. the ag ... | 2012 | 3435374 |
| reverse genetics approaches for cloning ril-1, a major locus involved in susceptibility to leukemia. | 2012 | 3416638 | |
| commonly adopted postures and their effect on the lumbar spine. | the activity of the erector spinae muscles and the changes in lumbar curvature were measured in 11 subjects in a range of commonly adopted postures to see if there were any consistent trends. surface electrodes were used to measure back muscle activity and lumbar curvature was measured using electronic inclinometers. the results showed that many commonly adopted postures reduced the lumbar lordosis when compared with erect standing or sitting, even at the expense of increasing the back muscle ac ... | 2012 | 3406840 |
| a pedigree of leber's congenital amaurosis. | a pedigree of leber's congenital amaurosis compatible with autosomal recessive trait is reported. two male infants from consanguineous parents had remarkable visual loss within the first year of life, with sluggish pupillary responses, poor fixations, minimal eyeground changes and absent electroretinograms on presentations at the ages of four or 14 months. follow-up studies revealed definite progressions of eyeground abnormalities consisting of attenuated retinal arterioles, pepper- and salt-lik ... | 2012 | 3405591 |
| natural cooling of the brain during outdoor bicycling? | tympanic membrane temperature (ttymp) and deep esophageal temperature (tes) were measured in 8 subjects during normal outdoor bicycling. metabolic rate (vo2) was determined by the douglas bag method. heart rate was sampled continuously. skin surface temperatures were measured at the forehead, chest and shoulder, and core temperatures in the deep esophagus and at the tympanic membrane using a radio telemetry system. for each outdoor experiment an indoor experiment in a climatic chamber, adjusted ... | 2012 | 3399365 |
| thyroglobulin and 131i uptake of remaining tissue in patients with differentiated carcinoma after thyroidectomy. | in 158 thyroidectomized patients with well-differentiated non-metastatic thyroid cancer the results of serum thyroglobulin (tg) determination and 131i uptake values established immediately before radioiodine treatment (19 days after surgery) were compared. in 113 patients (72%) tg was above 6 ng ml-1 (lower limit of detection) and 131i uptake exceeded 2%. in 11 patients (7%) tg was undetectable and 131i uptake less than 2%. in these cases a radioiodine treatment was not performed; the thyroid ab ... | 2012 | 3399222 |
| [ambulatory observation of patients with neuritis of the optic nerve]. | 2012 | 3387000 | |
| smooth muscle tumours of the digestive tract: report of 160 cases. | of 160 patients seen in the period 1951-84 with smooth muscle tumours of the digestive tract, 71 proved to have leiomyomas, 87 had leiomyosarcomas and 2 had leiomyoblastomas. tumour diameter was frequently greater in patients with leiomyosarcoma. the surgical mortality was 2.8 per cent after treatment of leiomyoma and 10.3 per cent after treatment of leiomyosarcoma. after resection of leiomyosarcoma the 2-year survival rate was 86 per cent and the 5-year survival rate was 43 per cent. the only h ... | 2012 | 3349313 |
| effects of adult and peer social initiations on the social behavior of withdrawn, maltreated preschool children. | 2012 | 3346446 | |
| simultaneous measurement of preferred ambient temperature and metabolism in rats. | a recent study from this laboratory found that rats placed in a temperature gradient preferred ambient temperatures (ta) that were significantly below the lower critical ta of the thermoneutral zone for elevating metabolic rate (mr). to further evaluate the interaction between preferred ta and mr in the rat, a system was developed where preferred ta, mr (i.e., o2 consumption), and activity could be automatically monitored in the unrestrained rat. two groups of male sprague-dawley rats, a light-w ... | 1988 | 3344833 |
| structural and functional studies of the amino terminus of yeast metallothionein. | purified yeast copper-metallothionein lacks 8 amino-terminal residues that are predicted from the dna sequence of its gene. the removed sequence is unusual for metallothionein in its high content of hydrophobic and aromatic residues and its similarity to mitochondrial leader sequences. to study the significance of this amino-terminal cleavage, several mutations were introduced into the metallothionein coding gene, cup1. one mutant, which deletes amino acid residues 2-8, had a minor effect on the ... | 1987 | 3308865 |
| [respiratory problems in patients with muscular dystrophy]. | 2011 | 3285556 | |
| hypergammaglobulinemia associated with human immunodeficiency virus infection. | the serum concentrations of 11 ig isotypes (igg, igg1, igg2, igg3, igg4, iga, iga1, iga2, igm, igd, and ige) were measured in four relatively small groups of homosexual (or bisexual) males. all these patients were seropositive for hiv. two of the groups (nonprogressors) were clinically stable for approximately 2 years and were characterized either as asymptomatic or with pgl. the third group (progressors) developed aids 2-38 months after blood specimens were taken. the fourth group had aids. a f ... | 1988 | 3260340 |
| synthesis and antineoplastic effects of furo[3,4-d]pyrimidine derivatives. | furo[3,4-d]pyrimidine was obtained in the reaction of 2-phenyl-4-phenylamino-6-methyl-5-pyrimidinecarboxylic acid with socl2. this compound, heated with aliphatic amines, yielded mono- and diamino-derivatives. some of the obtained compounds exhibited a potent antineoplastic activity. | 2011 | 3237569 |
| computer-aided molecular modelling: research study or research tool? | developments in computational methods and equipment have produced a new type of research chemist, who prefers to calculate properties as well as measure them, either to gain a better understanding of microscopic molecular behaviour per se, or to guide a broader scientific study using a so-called 'rational' approach. while there is good reason to believe that significant results can be obtained this way, it is clear that only some of the 'tools of the trade' are sufficiently robust to present to ... | 2011 | 3236047 |
| excision of cutaneous tumors in the horse using histologic guidance. | a highly successful surgical technique for removing cutaneous tumors in humans was used in seven horses with cutaneous squamous cell carcinoma (n = 3) or sarcoid (n = 4). in humans, the complete underside of the tumor is evaluated histologically by processing horizontal sections from the tumor base, and orientation between the wound surface and the undersurface of the excised tumor is maintained by mapping both surfaces. the technique ensures that small foci of residual tumor can be located accu ... | 1988 | 3227634 |
| physical and psychological sequelae to torture. a controlled clinical study of exiled asylum applicants. | the study comprised 24 male lebanese refugees living in denmark. twelve of them alleged having been tortured in lebanon during the period 1981-85. the remaining twelve had neither been imprisoned nor tortured and thus acted as control persons. all the testimonies were found to be valid according to a method previously used by the author. the most common forms of torture were blows against the head, body and foot soles, suspension and asphyxiation. threats and solitary confinement were frequent, ... | 2011 | 3209147 |
| studies on the factors affecting the haemolysin production of vibrio mimicus isolated from clinical and environmental sources. | the in vitro production of haemolysin by vibrio mimicus, a newly described aetiological agent for human diarrhoea, was determined using sheep erythrocytes. the effects of medium composition and sodium chloride concentration on haemolysin production and its heat stability were investigated. the haemolysin was produced optimally in brain-heart infusion broth and was unaffected by salt concentration up to 1.5%. however, haemolysin production decreased gradually with increasing concentrations of sal ... | 1988 | 3188168 |
| coagglutination of vibrio cholerae, vibrio mimicus, and vibrio vulnificus with anti-flagellar monoclonal antibody. | monoclonal antibodies (mabs) with serological activity for purified flagellar (h) core protein prepared from vibrio cholerae were identified by enzyme-linked immunosorbent assay. four of these mabs reacted with the flagella of v. cholerae and v. mimicus exclusively, while eight mabs reacted with at least 1 of 30 heterologous vibrio species tested by enzyme-linked immunosorbent assay or coagglutination. it appears that v. cholerae and v. mimicus express similar, if not identical, h determinants u ... | 1988 | 3182988 |
| structural and functional studies of the effects of sympathetic nerve stimulation on rabbit submandibular salivary glands. | continuous sympathetic stimulation at 8-10 hz caused intense vasoconstriction in the gland, so stimulation was generally given in an interrupted pattern to minimize this detrimental effect on secretion. only a small increase in fluid secretion occurred; it became thick and tended to block the cannula; therefore in later experiments the main duct was not cannulated. after sympathetic stimulation there was substantial degranulation of acinar cells. however, as this was accompanied by little moveme ... | 1988 | 3165262 |
| direct selection of mutations reducing transcription or translation of the reca gene of escherichia coli with a reca-lacz protein fusion. | when a reca-lacz protein fusion was cloned into phage lambda, the resulting transducing phage grew normally on wild-type escherichia coli, but its growth was severely inhibited in lexa(def) mutant strains that express reca constitutively at high levels. mutants of the transducing phage that grew on the lexa(def) strains were isolated and were found to affect production of the reca-beta-galactosidase hybrid protein. most mutants, including a number of nonsense mutants, were phenotypically lacz-. ... | 1985 | 3160689 |
| renal growth after neonatal urinary tract infection. | this study presents the result of 12-21 years' follow-up in a group of children with neonatal urinary tract infection (onset within 1 month after birth) in whom early renal growth retardation was noted without concomitant classical renal scarring. in all cases the neonatal infection was diagnosed and treated within a few days of onset and the patients were closely supervised thereafter. renal length, parenchymal thickness and area were measured at urography. at first follow-up (22 children, mean ... | 2010 | 3153287 |
| valproate-associated hepatotoxicity and its biochemical mechanisms. | intake of the anticonvulsant drug valproic acid, or its sodium salt, has been associated with occasional instances of severe and sometimes fatal hepatotoxicity. probably at least 80 cases have occurred worldwide. the syndrome affects perhaps 1 in 10,000 persons taking the drug, and usually develops in the early weeks or months of therapy. most instances have involved children, usually those receiving more than 1 anticonvulsant. multiple cases have occurred in 2 families. the typical presentation ... | 2011 | 3131628 |
| [enterostoma therapy--a pilot course in the essen education center of the german nursing association]. | 2011 | 3127632 | |
| increased cough reflex associated with angiotensin converting enzyme inhibitor cough. | 2011 | 3120857 | |
| oesophageal pain exacerbated by propranolol. | 2011 | 3113570 | |
| darkroom diseases and how to combat them. | 2011 | 3112384 | |
| biosynthesis and processing of platelet gpiib-iiia in human megakaryocytes. | platelet membrane glycoprotein iib-iiia forms a calcium-dependent heterodimer and constitutes the fibrinogen receptor on stimulated platelets. gpiib is a two-chain protein containing disulfide-linked alpha and beta subunits. gpiiia is a single chain protein. these proteins are synthesized in the bone marrow by megakaryocytes, but the study of their synthesis has been hampered by the difficulty in obtaining enriched population of megakaryocytes in large numbers. to examine the biosynthesis and pr ... | 1987 | 3108266 |
| annual summary 1984. reported morbidity and mortality in the united states. | 2011 | 3092006 | |
| second-generation cephalosporins. | 1986 | 3081544 | |
| [x-ray computed tomography in venous pathology]. | after presenting the tomodensitometric semiology of venous thromboses in various territories, the authors define its indications. it is essentially in deep territories, head, chest and abdomen that the ct-scan is used to study and diagnose unrecognized thromboses as well as determine the venous repercussion of various neighboring ailments. the respective place of the ct-scan, ultrasonography and various phlebographies is analyzed. | 2011 | 3043474 |
| the hypothalamic-pituitary-adrenal axis in depression. | 2010 | 3035885 | |
| role of postnatal gonadal function in the determination of thyrotropin (tsh) releasing hormone-induced tsh response in adult male and female rats. | permanent effects of postnatal gonadal function on the hypothalamo-pituitary-thyroid axis were examined in male and female rats of the wistar-imamichi strain. animals were used at the age of about 10 weeks. neonatally castrated (nc) males showed a significantly higher plasma tsh response to trh (10 micrograms/kg bw, ip) than males castrated at 1, 2, 3, 4, or 6 weeks of age. the tsh response in intact males was similar to that seen in nc males. neonatal androgenization of nc males with 100 microg ... | 1987 | 3032567 |
| gene expression and genetic engineering in the lens. friedenwald lecture. | 1987 | 3026987 | |
| evidence that a human soluble beta-galactoside-binding lectin is encoded by a family of genes. | two cdna clones were isolated by immunoscreening a human hepatoma cdna library with an antiserum that bound specifically to a human soluble beta-galactoside-binding lectin with mr of approximately 14,000. the deduced amino acid sequences of the inserts of these two clones show considerable homology with each other, the sequence of chicken skin beta-galactoside-binding lectin, and eight peptides derived from purified human lung lectin of mr approximately 14,000. however, the sequence differences ... | 1986 | 3020551 |
| evidence that a human soluble beta-galactoside-binding lectin is encoded by a family of genes. | two cdna clones were isolated by immunoscreening a human hepatoma cdna library with an antiserum that bound specifically to a human soluble beta-galactoside-binding lectin with mr of approximately 14,000. the deduced amino acid sequences of the inserts of these two clones show considerable homology with each other, the sequence of chicken skin beta-galactoside-binding lectin, and eight peptides derived from purified human lung lectin of mr approximately 14,000. however, the sequence differences ... | 1986 | 3020551 |
| molecular epidemiology of non-o1 vibrio cholerae and vibrio mimicus in the u.s. gulf coast region. | ten toxigenic vibrio cholerae non-o1 and v. mimicus strains isolated from clinical and environmental sources in the u.s. gulf coast region were examined for genetic relatedness. restriction digest patterns of chromosomal dna and southern blot analysis with a cholera toxin gene probe revealed that the strains exhibited greater genetic divergence than the highly conserved v. cholerae o1 strains isolated from clinical and sewage samples in this region. | 1986 | 3007571 |
| effect of pyrimidinone treatment on lethal and immunosuppressive murine cytomegalovirus infection. | the 2-amino-5-halo-pyrimidinones, which are potent interferon inducers and antiviral agents, were found to be protective against lethal cytomegalovirus (cmv) challenge in weanling or neonatal mice when administered before virus challenge. this protection was dependent upon the dosage of pyrimidinone administered. weanling mice infected with a sublethal challenge of cmv exhibited moderate to severe immunosuppression as measured by reduced splenic cell blastogenic responses in vitro to the mitogen ... | 1985 | 3000290 |
| the biologic significance of the mixed lymphocyte kidney culture in humans. | the mixed lymphocyte kidney culture (mlkc) in humans has been studied in normal and abnormal clinical conditions. human renal cortical cells were extracted by collagenase treatment from the kidneys of "normal" heart-beating cadaver organ donors (n = 13), patients with end-stage renal disease (esrd) at pretransplant bilateral nephrectomy and splenectomy (n = 13), and from irreversibly rejected renal allografts at the time of graft nephrectomy (n = 5). proliferation of peripheral blood t lymphocyt ... | 1985 | 2996186 |
| evidence of functional alpha 2-adrenergic receptors in adult-rat adipocytes by using the agonist uk 14304. | the aim of this study was to re-assess whether alpha 2-adrenergic receptors were present in rat adipocytes, by using uk 14304, a new and very selective alpha 2-agonist. the following observations demonstrate the presence of functional alpha 2-adrenoceptors in rat adipocytes. (1) adipocyte lipolysis was dose-dependently inhibited by uk 14304 (maximal effect 80% at 1 microm-uk 14304, 45% at 10 microm-uk 14304, under basal or theophylline-stimulated conditions respectively). (2) uk 14304 bound spec ... | 1988 | 2901830 |