| ca2+ regulation of the thin filaments: biochemical mechanism and physiological role. | | 2011 | 3208977 |
| [the morpho-functional test of blood lymphocytes in proliferative blood diseases. case reports]. | | 2015 | 4973516 |
| [condensation of phenols with halogenoacids using boron trifluoride (author's transl)]. | | 2016 | 4775944 |
| differentiated thyroid carcinomas: the relevance of various pathological features for tumour classification and prediction of tumour progress. | in this series of 263 surgically treated cases of thyroid cancer, 12% were finally classified as benign lesions after histopathological review. difficulty in the assessment of tumour capsule invasion in follicular neoplasms was the most frequent cause of diagnostic error. squamous metaplasia, clusters of ground glass nuclei and psammoma bodies were found to be the most specific discriminators between papillary and follicular carcinomas. among papillary carcinomas, tumour diameter above 30 mm, th ... | 2006 | 1636246 |
| letter: "febrile convulsions". | | 2014 | 4128751 |
| [chronic pancreatitis--with special reference to the relationship between clinical pathology and clinical practice]. | | 2015 | 4677405 |
| the role of magnesium in protein-energy malnutrition. | the present study was aiming to explore further the variations in the levels of mg in both serum and csf of pem children, hoping a better understanding revealed decreased values of both blood serum and csf levels of mg in pem children which denote some abnormalities in brain metabolism. such abnormalities add further support for assumption of the link between dietary insufficiency and subnormal mental performance in pem. | 1998 | 98923 |
| [relative cardiac output, cardiac output quotient, and cardiac volume under graded ergometer exertion during various training conditions. possibilities for simplified function tests on heart and blood circulation]. | | 2015 | 4663550 |
| dental services in commerce. | | 2003 | 298676 |
| [humeroscapular periarthritis]. | | 2008 | 2620726 |
| [humeroscapular periarthritis]. | | 2008 | 2620726 |
| [radiography of the nasopharynx and pharynx]. | | 2011 | 3225927 |
| herniation of an intervertebral disc with cauda compression syndrome in childhood. | a case of a lumbosacral disc herniation of traumatic origin with compression of the cauda equina in a child is reported. the problems of early diagnosis, timely operative procedure, and prognosis of neurological deficit of operated disc herniation in childhood are discussed. | 1999 | 91675 |
| [anatomo-pathological, clinical and statistical considerations on the phenomenon of sudden death]. | | 2016 | 4921485 |
| the structural basis of crystal-induced membranolysis. | | 2003 | 181020 |
| biotechnology in japan--towards the year 2000 ... and beyond. | | 2006 | 1367243 |
| [respiratory problems in patients with muscular dystrophy]. | | 2011 | 3285556 |
| [studies on the blood constituents of the neonates delivered by the induced delivery of the defense medical college method]. | for the assessment of the influence of the defense medical college planned delivery method upon neonates, the measurement of the blood constituents of the umbilical cord was conducted. statistically speaking, no marked differences were seen between the neonates delivered by the defense medical college method and neonates delivered naturally. the blood constituents investigated were: blood cells, activity of various enzymes, other blood constituents and electrolytes. | 2012 | 3457089 |
| the rubella immunity gap. | | 2001 | 87852 |
| control of post-operative infection. a comparative evaluation of clindamycin and phenoxymethylpenicillin. | | 2015 | 4631901 |
| myocardial cell damage in "stone hearts". | | 2014 | 4277587 |
| colony-stimulating factor and drug-induced agranulocytosis. | | 2008 | 2655524 |
| myocardial cell damage in "stone hearts". | | 2014 | 4277587 |
| [antidepressive treatment with nortriptyline]. | | 2005 | 1233907 |
| colony-stimulating factor and drug-induced agranulocytosis. | | 2008 | 2655524 |
| altered sensitivity of the gallbladder to cholecystokinin octapeptide in irritable bowel syndrome. | we compared responses of the gallbladder to graded intravenous infusions of cholecystokinin octapeptide (cck-op) in normal controls (n = 8) and patients with irritable bowel syndrome (ibs) with predominant constipation (n = 8) or diarrhea (n = 8). the doses of cck-op ranged from subphysiological (negligible contraction of the gallbladder) to supraphysiological (90% contraction of gallbladder and abdominal side effects) amounts. all gallbladders contracted progressively in response to cck-op, and ... | 2012 | 3318495 |
| [alpha-amylase polymorphism. 1. a comparative study of alpha-amylase hp and gm]. | individual phenotypes, phenotypical and genetic frequencies of the alpha-amylase enzyme have been established by means of populational genetic researches. the most common phenotype is amyla amyl2a (85.15%) followed by amyla amyl2a 2b (6.27%), amylaib amyl2a (5.37%), amyl ia amyl2a 2b (2.15%), amyla amyl2b (0.53%), amylc amyl2b (0.35%), amylc amyl2a 2b (0.18%). the difference between the observed and theoretically expected phenotypes of amy, hp and m gm(1) is insignificant. the examined contingen ... | 2008 | 2627896 |
| a flow calorimeter for assay of hormone- and metabolite-induced changes in steady-state heat production by tissue. | | 2005 | 543542 |
| [electromyography of the perineal plane with cutaneous electrodes in routine urodynamic examinations]. | | 2014 | 4081958 |
| polycyclic aromatic compounds (pac) in leaf lettuce. | twenty-three samples of leaf lettuce (lactuca sativa var. crispa) cultivated in private gardens in southern finland were analyzed for polycyclic aromatic hydrocarbons (pah) and derivatives. the total pah concentrations varied from 4.8 to 94 micrograms/kg fresh weight. nitro derivatives of pah were detected in only five samples. one lettuce sample was also analyzed for pah oxy-derivatives. 9h-fluoren-9-one (1.3 microgram/kg) and 6 h-benzo[cd]pyren-6-one (0.3 microgram/kg) were found. the profiles ... | 2013 | 3765856 |
| [analysis of hba1 is necessary in the routine check-up of patients with type 2 diabetes mellitus]. | | 2013 | 3807486 |
| dosimetric mapping inside biorack on d1. | | 2013 | 3762715 |
| androblastoma and germ cell tumor of the same testis: a case report. | the rare case of a testicular androblastoma associated with a complex germ cell tumor of the same testis is reported. gynecomastia preceded the clinical appearace of testicular swelling by 3 months, suggesting that the 2 tumors developed contemporaneously and that, in theory, the sertoli cell tumor is probably dependent on the germ cell tumor. | 2003 | 165324 |
| hydroxylation of proline in polytripeptide models of collagen: stereochemistry of polytripeptide-prolyl hydroxylase interaction. | | 1990 | 210786 |
| activities of the modified polyene n-d-ornithyl amphotericin methyl ester and the azoles ici 153066, bay n 7133, and bay l 9139 compared with those of amphotericin b and ketoconazole in the therapy of experimental blastomycosis. | we studied the efficacy of new experimental antifungal drugs, which represent molecular modifications of present active agents, in a murine model of blastomycosis. ketoconazole, previously the best azole drug studied and which is protective when administered orally, was superior to a new oral imidazole, bay l 9139, and a new oral triazole, bay n 7133. a new oral triazole, ici 153066, was markedly more effective than ketoconazole and is the only oral drug studied which came close to producing com ... | 2014 | 3994350 |
| think about your pension! | | 2013 | 3866716 |
| the pensacola story. | | 2015 | 4551267 |
| [clinical study of the efficacy of devices for electronic measurement of the working length]. | | 2012 | 3474721 |
| acute intoxication as a cause of wild bird mortality in the netherlands from 1975-1989. | | 2007 | 1805755 |
| immunocytochemical characterization of the lymphocytes in nodular lymphoid hyperplasia of the bowel. | the immunoglobulin constituents of hypertrophied lymphoid nodules in the intestinal tracts of six patients with the variable immunodeficiency syndrome and one patient with selective iga deficiency were evaluated by the peroxidase-labeled antibody technique. the nodules were found to contain a dense population of igm-bearing lymphocytes and much intercellular igm. evidence that the cells were engaged in igm synthesis was the presence of the immunoglobulin in the perinuclear spaces and endoplasmic ... | 1998 | 105208 |
| letter: the critical coronary disease patient. | | 1992 | 1130748 |
| teaching discharge planning. | | 1996 | 177953 |
| ct metrizamide myelography for intraspinal and paraspinal neoplasms in infants and children. | computed tomography (ct) metrizamide myelography is an accurate and satisfactory method for examining the spinal cord in infants and children with suspected intraspinal neoplasms. it was performed in 13 infants and children and in one adult with intra- and paraspinal neoplasms. ct metrizamide myelography in paraspinal masses provides the total geography of the mass; that is, possible intraspinal extension, as well as the paraspinal portion itself. as such, it is superior to conventional myelogra ... | 1998 | 106638 |
| catheter cervical vertebral venography. | cervical vertebral venography using catheterzation via the femoral vein was carried out in 78 cases. in disc disease the internal vertebral venous plexus (ivvp) are interrupted at single or multiple levels, and sometimes completely blocked. in ossification of posterior longitudinal ligament, the ivvp are separated bilaterally and interrupted at multiple levels due to centrally situated ossification and associated osteophytes. venography helps to determine the upper and lower limits of laminectom ... | 1998 | 106325 |
| plasma arginine vasopressin in diabetic ketoacidosis. | plasma arginine vasopressin (avp) was measured serially in 10 patients during the first 24 hours of treatment of diabetic ketoacidosis. avp was elevated in all cases initially, ranging from 4.0--122.0 pmol/l, the basal level in healthy hydrated subjects being 1.57 +/- 0.59 pmol/l (+/- 1 sd). the levels fell progressively during the course of treatment. while there was no evidence that the massive increases in avp noted in this study were associated with water overload it remains to be determined ... | 1999 | 103767 |
| biochemical changes in the skin of mink with ehlers-danlos syndrome: increased collagen biosynthesis in the dermis of affected mink. | | 1999 | 21930 |
| chido, rodgers and c4. in vivo and in vitro coating of red blood cells, grouping and antibody detection. | c4 sucrose/low ionic strength (lis)-coated red blood cells (rbc) are excellent for the detection of the previously 'nebulous' antibodies, anti-chido and anti-rodgers, as well as for serum/plasma typing of these antigens by an inhibition technique. by enzyme treatment of such cells, it is confirmed that the ch and rg antigens reside on the c4d part of the c4 molecule. freshly taken rbc from normal individuals were examined with a sensitive auto-analyzer technique with anti-chido, anti-c4 and anti ... | 1999 | 91269 |
| substances modulating the secretion of acth by cultured anterior pituitary cells. | | 1999 | 17552 |
| tetralogy of fallot in adults. | | 1999 | 91440 |
| clinical trial of topical disodium chromoglycate in vernal keratoconjunctivitis. | the clinical picture of spring catarrh was studied in 96 cases. the duration of the disease was found to be 3.5 +/- 2.6 years. it exists all the year round with a higher frequency between april and august. male children were affected about three times more frequently than females. the effect of dscg was studied in 20 cases. it had a significant therapeutic effect. we advise a combined dscg and corticosteroid treatment in the period of exacerbation. | 2000 | 101923 |
| lack of uniformity in colour matching. | 1. the fraction of red in a red--green mixture matched to yellow increased as the intensities of the match constituents were increased sufficiently to bleach appreciable chlorolabe and erythrolabe. 2. all changes in matching found for a given normal trichromat, (i) with increase in the intensities of the matching components, (ii) as a function of time after the onset of very intense components, (iii) with change in the pupil region through which light enters the eye, and (iv) with change in the ... | 2000 | 313984 |
| [evaluation of blood-liquor barrier by protein gradients in congenital hydrocephalus in infancy]. | | 1999 | 88669 |
| ectopic pregnancy in southern iran: a statistical review of 96 cases. | a review is presented of 96 cases of ectopic pregnacy over a 7-year period. it is noted that in recent years the incidence of this problem has increased. inadequately diagnosed and treated pelvic inflammatory disease has been found to be the main predisposing factor (40%). the rate of extra-uterine gestation was 1:336 deliveries. in this study, previous fertility was high, and primigravidae constituted only 10.4% of the total. the effect of previous pelvic operations and pelvic infection is disc ... | 1999 | 15916 |
| histochemical study of orcein-positive hepatocellular material in paraffin sections of liver biopsy samples in the course of various liver diseases. | a histochemical study was carried out on orcein-positive hepatocellular material in 111 cases, 27 of which were stained positively by orcein. orcein-positive material was very frequently found in protracted viral hepatitis and in chronic active hepatitis, as well as in other liver diseases with or without cholestasis; it was absent in liver cirrhosis. in all the cases considered the orcein-positive material was mainly formed of proteins, rich in amino acids with sulfhydryl and disulphide radical ... | 1999 | 91188 |
| [diverticula of the duodenal orifice]. | the authors present a synthesis of data from the literature, as well as of particularities that have confronted them in connection with 16 observations of mucous diverticuli of duodenal windows (of which 7 were interposed and 9 were juxtaposed). after a definition of the window diverticuli, of their types and of their repercussions, clinical data are commented upon, the possibilities offered by paraclinical investigations and by the intra-operatory methods, as well as the different therapeutical ... | 2000 | 111314 |
| [clinical application of beta 2-microglobulin measurement in malignant disease (author's transl)]. | | 2000 | 92044 |
| transmission of hepatitis b by immune serum globulin. | | 2001 | 93197 |
| antimalaria studies on qinghaosu. | | 2001 | 117984 |
| editorial: medicine-1975. | | 2002 | 123904 |
| the independent living centre. | | 2003 | 161503 |
| renewed voluntary spirit needed, says blue cross;. | | 2002 | 139559 |
| [study of left ventricular function with quantitative angiocardiographic methods]. | | 2003 | 161533 |
| preparation of liposomes of defined size distribution by extrusion through polycarbonate membranes. | liposomes of defined size and homogeneity have been prepared by sequential extrusion of the usual multilamellar vesicles through polycarbonate membranes. the process is easy, reproducible, produces no detectable degradation of the phospholipids, and can double the encapsulation efficiency of the liposome preparation. multilamellar vesicles extruded by this technique are shown by both negative stain and freeze-fracture electron microscopy to have mean diameters approaching the pore diameter of th ... | 2001 | 95096 |
| vaginal epithelial changes associated with in utero des exposure. | to determine the true prevalence of vaginal epithelial changes in des-exposed offspring, the national cancer institute funded the desad project, a study designed to follow up these women for 4 years and to determine the prevalence of cancer and various other abnormalities in des-exposed women. 3339 women have constituted the project study cohort as of 12/31/76. each woman in the desad project undergoes breast, pelvic and colposcopic examinations, as well as vaginal and cervical cytology. details ... | 2004 | 523034 |
| congressman normal mineta: keeping tabs on the clean water act. interview by donald feliciano. | | 2004 | 522208 |
| the problem with vitamin b12 testing. | | 2004 | 522179 |
| an analysis of nonconfirmation rates. experiences of a surgical second opinion program. | a review was conducted of the first 12 months' experience with a voluntary second opinion surgery consultation program. the program covers approximately 950,000 persons: employees of the city of new york, retirees, and their dependents. on a simple yes or no basis, the program's surgical nonconfirmation rate was 25%. more detailed analysis of consultants' narrative suggestions for patient care showed that a firm rejection of surgical intervention occurred in only 8% of the cases reviewed. noncon ... | 2004 | 490854 |
| [inhibition of postoperative catabolism with bradykinin]. | | 2004 | 421629 |
| bloody pleural effusion associated with an intralobar pulmonary sequestration. | a 50-year-old male cigarette smoker with a posterior parenchymal lung mass developed a bloody, exudative pleural effusion. pathologic examination of the resected lung confirmed the preoperative diagnosis of an intralobar pulmonary sequestration. | 2004 | 421588 |
| transventricular blood vessels in the third ventricle of the armadillo brain. | transventricular filaments were observed with scanning electron microscopy on the dorsolateral wall of the infundibular recess of the third ventricle of the armadillo brain. two to seven transventricular filaments per animal were present in 6 of 18 animals. there were two types of transventricular filaments, ciliated and bare. using transmission electron microscopy, we determined that these filaments consisted of a single, central capillary surrounded by ciliated ependymal cells and a small accu ... | 2004 | 443562 |
| diffusion in immobilized-cell gels. | the relationship between the diffusion coefficient, the effective diffusion coefficient and the partition coefficient for a solute in a cell-containing gel is discussed. the use of correlation equations that are based on some kind of physical model is recommended when the effect of cell concentration on diffusion is interpreted. | 2005 | 1367033 |
| serum-free media and cell cultures. introductory remarks. | | 2005 | 1367047 |
| diffusion in immobilized-cell gels. | the relationship between the diffusion coefficient, the effective diffusion coefficient and the partition coefficient for a solute in a cell-containing gel is discussed. the use of correlation equations that are based on some kind of physical model is recommended when the effect of cell concentration on diffusion is interpreted. | 2005 | 1367033 |
| serum-free media and cell cultures. introductory remarks. | | 2005 | 1367047 |
| low-income widows and other aged singles. | based on data collected in a nationwide survey in late 1973, this report describes the living conditions, health, social activity, and attitudes of unmarried older persons at low to middle income levels--that is, below $5,000 per year. although most previous research has focused on the special situation of widows, the current findings indicate that lower income widowers and divorced/separated/never-married persons generally experience many of the same problems as the widows and respond to them i ... | 2005 | 545715 |
| synthesis and duplex stability of oligonucleotides containing adenine-guanine analogues. | the nucleosides n6-methoxy-2'-deoxyadenosine (dz) and 2-amino-9-(2-deoxy-beta-ribofuranosyl)-6-methoxyaminopurine (dk) have been synthesised and converted into 5'-o-dimethoxytrityl 3'-(2-cyanoethyl n,n-diisopropylphosphoramidites). these monomers have been used in machine dna synthesis to give a set of heptadecanucleotides containing up to three analogue nucleotides. the melting transitions (tm) show that the 17-mer duplexes containing z.t and z.c base-pairs have closely similar stabilities, as ... | 2006 | 1797376 |
| [infections in immunosuppressed patients]. | | 2005 | 544237 |
| practical methods for preservation of cultured cells by freezing. | | 2005 | 1366945 |
| synthesis and duplex stability of oligonucleotides containing adenine-guanine analogues. | the nucleosides n6-methoxy-2'-deoxyadenosine (dz) and 2-amino-9-(2-deoxy-beta-ribofuranosyl)-6-methoxyaminopurine (dk) have been synthesised and converted into 5'-o-dimethoxytrityl 3'-(2-cyanoethyl n,n-diisopropylphosphoramidites). these monomers have been used in machine dna synthesis to give a set of heptadecanucleotides containing up to three analogue nucleotides. the melting transitions (tm) show that the 17-mer duplexes containing z.t and z.c base-pairs have closely similar stabilities, as ... | 2006 | 1797376 |
| [excitation-contraction coupling and ion transport in membrane of skeletal muscle]. | | 2006 | 1698230 |
| a nonexponential, nonlogarithmic pharmacokinetic dosing method for gentamicin. | | 2007 | 1914430 |
| [cornea bank: an increase in the number of transplantations is possible]. | | 2006 | 1636297 |
| diagnosis and management of the dandy-walker malformation: 30 years of experience. | thirty-seven patients with dandy-walker malformation were treated between 1959 and 1989. eighty percent of patients became symptomatic by 3 years of age, with 70% presenting within the 1st year of life. hydrocephalus was present in 91% of patients at the time of diagnosis. clinical presentation was most often heralded by symptoms and signs of hydrocephalus with focal neurological findings being a less prominent feature. one third of children demonstrated developmental delay. associated congenita ... | 2006 | 1472430 |
| [long-term results of the treatment of ruptured intracranial aneurysms. study of a series of 328 patients hospitalized from 1972 to 1984]. | between 1972 to 1984, 328 patients were admitted in the department of neurosurgery, for the treatment of a ruptured intracranial aneurysm, and being clinically in grades i to iv. these patients were submitted to a deferred surgery protocol. 5.5% of the patients died before surgery, and 94.5% were actually operated on. the follow-up was at least over one year, and up to 14 years (mean 3 years and 8 months). the long term result was appreciated according to the physical status of the patients and ... | 2007 | 3374722 |
| the biology of the scid mutation. | | 2008 | 2519515 |
| terminal component of complement (c9) in the cerebrospinal fluid of patients with multiple sclerosis and neurologic controls. | we measured the concentration of c9 in the csf and plasma of 93 consecutive patients referred for csf examination in an outpatient multispecialty clinic. we noted no differences in csf c9 or c9 index between patients with multiple sclerosis and neurologic controls. | 2007 | 2330118 |
| reflections on tissue characterisation. | theoretical predictions that absorption and velocity dispersion, in addition to characteristic acoustic impedance mismatch, mediate the reflectivity of a planar interface are explored. a technique to measure the frequency dependence of the reflectivity is described: a special hydrophone, purpose-built to this end, is utilised in order to show that perspex/water and neoprene/water reflectivities are not inconsistent with the general predictions of the theory. an approach towards displaying, simul ... | 2008 | 2587629 |
| the paraphilias and depo-provera: some medical, ethical and legal considerations. | paraphilic disorders are axis i psychiatric afflictions. they are not acquired by volitional decision, but are manifested by the association of erotic arousal with unacceptable behavior or stimulae (e.g., children). because paraphilic behavior occurs in the service of a biological drive, use of medication to suppress sexual appetite may constitute an adjunct in treatment. medroxyprogesterone can be used to decrease unacceptable erotic urges and fantasies, with the intent of increasing self-contr ... | 2008 | 2529006 |
| testis position and age at orchidopexy. | | 2008 | 2885626 |
| [treatment of bacillary dysentery with wintomylon]. | | 2009 | 4962909 |
| cetus banks on interleukin. | | 2009 | 2787891 |
| solitary congenital nodular calcification of winer located on the ear: report of two cases. | solitary congenital nodular calcification of the skin is a form of cutaneous calcinosis. it appears as a small, firm nodule on the head and extremities of young infants. the histogenesis of this condition is controversial. we cared for two patients with the nodule on the ear. | 2009 | 2798256 |
| solitary congenital nodular calcification of winer located on the ear: report of two cases. | solitary congenital nodular calcification of the skin is a form of cutaneous calcinosis. it appears as a small, firm nodule on the head and extremities of young infants. the histogenesis of this condition is controversial. we cared for two patients with the nodule on the ear. | 2009 | 2798256 |
| anomalous origin of right pulmonary artery from the ascending aorta. | anomalous origin of one pulmonary artery from the ascending aorta without associated intracardiac defects is a rare congenital malformation. about 60 anatomic and surgical descriptions have been reported in the literature. up to 1974, 22 of the 50 reported cases underwent surgical correction with a 40% mortality rate. the natural history without surgery is poor with a very high mortality during the first year of life. successful anatomic correction of anomalous origin of right pulmonary artery f ... | 2009 | 2777879 |
| [reservoirs of resistance plasmids]. | | 2009 | 3327947 |
| [children and domestic fights. a review of 105 social reports]. | the object of this investigation was to describe the conditions for children in families with domestic rows on the basis of 105 social reports made by the copenhagen police during a period of one year. a total of 162 children were involved in domestic rows. the typical family had 1-2 children. in 14% of the cases, the domestic rows were reported by the child. in connection with the domestic rows, violence to the women occurred in just under half of the cases and to the children in 6%. in 77% of ... | 2009 | 2711507 |
| [methods of capsular and intracapsular microsurgery, intracapsular implantation and sutureless fixation of artificial lenses]. | the author recommends mastering the methods of capsular and intracapsular microsurgery for cataracts on cadaver eyes. he advises to remove the cornea and the iris to have a better view of the technique. as the physician masters the technique, he screens the lens sac equatorial area by keeping the iris and later the cornea (to make the conditions as close to clinical surgery as possible) and then removes the iris and the cornea for controlling the quality of the capsular pocket preparation. artif ... | 2009 | 2718300 |
| listening rate and comprehension as a function of preference for and exposure to time-altered speech. | we conducted experiments on the effects of brief prior exposure to time-altered speech on preferred listening rate and the rate listeners would select when asked to listen to speech as fast as possible with good compression (induced listening rate). in exp. 1, 48 participants were exposed either to normal rate speech or to speech compressed to twice-normal rate. brief exposure to twice-normal rate speech led to a faster induced listening rate than exposure to normal rate speech. in exp. 2, 31 pa ... | 2009 | 2717361 |
| success of etched-metal bonded retainers with nonrigid connections: a clinical study. | the use of etched-metal bonded retainers in combination with conventional fixed retainers has been described in the literature. this design creates several potential problems that can be overcome by the use of an etched-metal bonded retainer with a nonrigid connector as described in this article. also presented are the preliminary results of a clinical study of 25 restorations that had been in place 13 to 45 months (average 22 months). the preliminary results are encouraging. no failures have be ... | 2009 | 2681695 |
| the immune response to intraparenchymal fetal cns transplants. | | 2009 | 2650446 |