Publications

in vitro evidence for an inhibitor of lipogenesis in serum from overfed obese rats.	involvement of a humoral agent in regulation of energy balance has been demonstrated by parabiosis experiments. overfed obese rats produce a blood-borne factor that inhibits adipose fatty acid synthesis in their partners, resulting in loss of body fat without significant inhibition of food intake. an in vitro bioassay was developed to test small serum samples for antilipogenic activity. epididymal adipocytes from ad libitum-fed rats were preincubated for 12 h with 2% serum. basal adipocyte fatty ...	1989	2764157
[mass screening for endometrial cancer according to the law of health for the elderly].	due to the gradual increase of endometrial cancer, mass screening for this type of cancer began from 1987 in japan in accordance with the law of health for the elderly. however, a screening system for endometrial cancer has many controversial problems when compared with that for cervix cancer. criteria for screening, methods of screening, management after screening, and executive systems are all controversial points in the performance of mass screening. the actual condition in the detection of e ...	2009	2772434
patient's advocate: children with cancer still deserve a childhood.		2009	2772527
cosleeping and sleep problems in hispanic-american urban young children.	to assess whether the traditional pediatric prohibition against cosleeping in the parental bed requires reconsideration for urban ethnic minorities, cosleeping and sleep problems were studied in a sample of hispanic-american, east harlem, new york city, children 6 to 48 months of age. the incidence of frequent all-night cosleeping was found to be 21%, significantly higher than the documented rate of 6% found in a representative sample of white middle-american urban children of the same age and s ...	2009	2788867
death due to disruption of sternal fixation wire--a rare complication after open heart surgery through sternotomy: report of a case.	following sternotomy for open heart surgery, a 57-year-old man had the sternum closed in the usual manner with six no.22 gauge stainless steel wire sutures. twenty-four days later, sternum disruption occurred with only one wire suture in place, 3 wire sutures cutting through the bone, and 2 wire sutures fractured. a lacerating injury over the anterior surface of the right ventricle was rendered by these 2 fractured wires followed by fatal outcome. to our knowledge, death induced by fractured wir ...	1989	2794943
[the effect of progesterone, testosterone and estradiol on steroid hormone release by the ovarian follicles of cows in vitro].		1989	2806660
comparison of cefazolin, cefamandole, vancomycin, and ly146032 for prophylaxis of experimental staphylococcus epidermidis endocarditis.	we evaluated antibiotic prophylaxis in the rabbit model of experimental endocarditis with three strains of staphylococcus epidermidis of differing susceptibility patterns. for the first strain, which was highly susceptible to methicillin and cephalosporins, vegetations grew s. epidermidis for all 15 untreated rabbits compared with 1 of 20 rabbits receiving cefazolin, 3 of 20 receiving cefamandole, none of 20 receiving vancomycin, and none of 20 receiving ly146032. for the second strain, which wa ...	1988	2831815
mechanism of the epsp synthase catalyzed reaction: evidence for the lack of a covalent carboxyvinyl intermediate in catalysis.	in order to detect covalent reaction intermediates in the 5-enolpyruvylshikimate-3-phosphate (epsp) synthase reaction, we have investigated the interaction of epsp synthase with the reaction product epsp. an exchange of epsp-methylene protons could be demonstrated by incubating epsps with epsp in d2o. since trace amounts of contaminating pi would lead to reversal of epsps reaction and hence methylene proton exchange, we added pyruvate kinase, adp, mg++ and k+. under these conditions, any contami ...	1988	2838023
influence of immunomodulatory agents on bovine humoral and cellular immune responses to parenteral inoculation with bovine rotavirus vaccines.	sodium diethyldithiocarbamate (dtc), mycobacterium cell wall extract (mcwe, regressin), killed corynebacterium parvum (c. parvum, immunoregulin) and muramyldipeptide (mdp) were each combined with purified, live bovine rotavirus and inoculated into 3 month-old holstein-friesian calves in order to examine their ability to potentiate specific humoral and cellular immune responses. the vaccinated calves were boosted twice at 3 and 6 weeks after initial vaccine inoculation. the rotavirus was administ ...	1988	2847397
serotonergic regulation of the brain and gut beta-endorphin and dynorphin content in the rat.	a specific radioimmunoassay was used to measure immunoreactive dynorphin (ir-dyn) and beta-endorphin (ir-be) in the brain, pituitary and gut, following a pharmacological manipulation of the serotonin system. administration of the serotonin receptor agonist m-chlorophenylpiperazine (m-cpp, 2.5-5 mg/kg ip) or the serotonin releasing agent fenfluramine (20-40 mg/kg ip) induced a significant increase in the hypothalamic ir-be content and a decrease in its anterior pituitary level. these effects were ...	1985	2870487
anatomical defects and variations due to aneuploidy.		1987	2953395
nitrous oxide and day-case laparoscopy: effects on nausea, vomiting and return to normal activity.	patients admitted for day-case laparoscopy were assigned randomly to receive nitrous oxide-oxygen or oxygen, with enflurane, during a standard anaesthetic technique. postoperative morbidity, in particular nausea and vomiting, and ability to resume normal activity were assessed over the ensuing 48 h. supplementary administration of propofol during the operative procedure was required significantly more often (p less than 0.05) in the absence of nitrous oxide. there was no significant difference i ...	2010	2967712
localization and comparative nucleotide sequence analysis of the transforming domain in herpes simplex virus dna containing repetitive genetic elements.	the 7.5-kilobase bamhi e fragment (bamhi-e) of herpes simplex virus type 2 (hsv-2) dna (map position 0.533-0.583) encodes the 144-kda subunit of ribonucleotide reductase and induces the neoplastic transformation of immortalized cell lines. to define the minimal transforming region of bamhi-e, a series of subclones were constructed that spanned the entire fragment. these subclones were assayed for focus formation in rat-2 cells. removal of the promoter region from the viral 144-kda-protein gene l ...	1986	3020562
localization and comparative nucleotide sequence analysis of the transforming domain in herpes simplex virus dna containing repetitive genetic elements.	the 7.5-kilobase bamhi e fragment (bamhi-e) of herpes simplex virus type 2 (hsv-2) dna (map position 0.533-0.583) encodes the 144-kda subunit of ribonucleotide reductase and induces the neoplastic transformation of immortalized cell lines. to define the minimal transforming region of bamhi-e, a series of subclones were constructed that spanned the entire fragment. these subclones were assayed for focus formation in rat-2 cells. removal of the promoter region from the viral 144-kda-protein gene l ...	1986	3020562
the antihypertensive effect of angiotensin-converting enzyme inhibition: a multifaceted mechanism of action.		2010	3030977
fulminant leukemic polyradiculoneuropathy in a case of b-cell prolymphocytic leukemia. a clinicopathologic report.	a 52 year old man with a 10-month history of b-cell prolymphocytic leukemia (pll) died of an apparent acute fulminant polyradiculoneuropathy, a condition generally attributed to paraneoplastic complication. the pathologic examination disclosed diffuse leukemic infiltrations of the peripheral nervous system. it is suggested that this particularly aggressive form of b-cell chronic prolymphocytic leukemia presented a constellation of features that promoted the invasion of the peripheral nervous sys ...	1987	3040217
decreased gastro-intestinal responses to salbutamol and serotonin in streptozotocin-induced diabetes: improving effect of insulin in vivo and in vitro.	1. decreased gastro-intestinal responses to salbutamol (sal) and serotonin (5-ht) in experimental diabetes have been postulated. the present study was designed to investigate whether in vivo and in vitro insulin treatments improve the decreased gastro-intestinal responses. 2. in vivo insulin treatment (166.7 micrograms/kg/day i.p.) for 6 weeks is able to improve both decreased gastro-intestinal beta-adrenergic and serotonergic responses. 3. insulin incubation in bathing medium for 4-5 hr enhance ...	1988	3063593
decreased gastro-intestinal responses to salbutamol and serotonin in streptozotocin-induced diabetes: improving effect of insulin in vivo and in vitro.	1. decreased gastro-intestinal responses to salbutamol (sal) and serotonin (5-ht) in experimental diabetes have been postulated. the present study was designed to investigate whether in vivo and in vitro insulin treatments improve the decreased gastro-intestinal responses. 2. in vivo insulin treatment (166.7 micrograms/kg/day i.p.) for 6 weeks is able to improve both decreased gastro-intestinal beta-adrenergic and serotonergic responses. 3. insulin incubation in bathing medium for 4-5 hr enhance ...	1988	3063593
emphasis on preventive perinatology: a suitable alternative for developing countries.	the potential efficacy of preventive interventions in latin america to reduce perinatal morbidity and mortality is reviewed. the most important perinatal risk factors associated with pregnancy and delivery are young age of the mother, low socioeconomic status, low education, malnutrition, lack of prenatal care, pregnancy-induced-hypertension, perinatal infections, alcohol, smoking, and iatrogenic causes. adequate data are lacking to determine the magnitude of these factors in latin america. iatr ...	2011	3065947
effect of acute ethanol administration on human blood aldehyde dehydrogenase activity.	the aldehyde dehydrogenase (ec 1.2.1.3) activity in human blood was measured after acute oral administration of two different doses of ethanol to healthy subjects. no changes in aldehyde dehydrogenase activity were observed in either of the two dose groups, as compared to control subjects receiving no ethanol. likewise, incubation of human whole blood samples with 20 mm ethanol for 2 hr caused no change in aldehyde dehydrogenase activity. the results show that human blood aldehyde dehydrogenase ...	1988	3067608
[modification of hcg secretion by biological modulators of cell response and cytostatics in the normal placenta and choriocarcinoma cells].		2011	3069634
effects of insulin on glucose transporters and metabolic patterns in harding-passey melanoma cells.	the effect of insulin on glucose metabolism through different pathways and the glucose transporters in harding-passey melanoma cells have been studied. glucose was utilized at a rate of 6.9 +/- 2.3 (sd) mumol x g-1 x h-1 with 86% transformed into lactate and pyruvate and only 0.43 and 3% metabolized through the tricarboxylic acid cycle and the pentose phosphate pathway, respectively. of the total glucose consumed 2% was used in protein synthesis and 2% was used for lipid synthesis. hexokinase is ...	2011	3089579
cerebral perfusion pressure: a hemodynamic mechanism of mannitol and the postmannitol hemogram.	sixteen patients each received infusions of 1 g of mannitol per kg over 5 to 10 minutes, and serial determinations of intracranial pressure (icp), systemic arterial blood pressure (sabp), central venous pressure, cerebral perfusion pressure (cpp), hematocrit, hemoglobin, serum na+, k+, osmolarity, and fluid balance were carried out for 4 hours. urine output was replaced volume for volume with 5% dextrose in 0.45% nacl solution. we tested the hypothesis that patients with high (greater than or eq ...	2010	3116451
interferon-gamma-induced degradation of tryptophan by human cells in vitro.	several human cells were investigated for their ability to degrade tryptophan and to synthesize neopterin upon induction by interferon-gamma (500 units/ml for 48 h). concentrations of tryptophan, kynurenine, 3-hydroxykynurenine, anthranilic acid, 3-hydroxyanthranilic acid, 7,8-dihydroneopterin and neopterin were assessed in the culture supernatants by hplc. fibroblasts, a-22 arachnoidea, hk-2351 scalp, t-2346 meningeom and hela cervical carcinoma cells but not hl-60 promyelocytic leukaemia cells ...	1987	3122784
bioaffinity sensors.		2011	3131631
thyrotropic and peripheral activities of thyrotrophin and thyrotrophin-releasing hormone in the chick embryo and adult chicken.	the influence of an intravenous injection of thyrotrophin-releasing hormone (trh) and bovine thyrotrophin (tsh) on circulating levels of thyroid hormones and the liver 5'-monodeiodination (5'-d) activity is studied in the chick embryo and the adult chicken. in the 18-day-old chick embryo, an injection of 1 microgram trh and 0.01 i.u. tsh increase plasma concentrations of triiodothyronine (t3) and of thyroxine (t4). trh, however, preferentially raises plasma levels of t3, resulting in an increase ...	1988	3133299
experimental evidence for enteropathogenicity in aeromonas veronii.	eleven ornithine-positive strains of aeromonas (9 a. veronii and 2 provisionally classified as aeromonas species ornithine positive) were tested for ability to cause fluid accumulation in the rabbit ileal loop. all eight beta-hemolytic strains caused fluid accumulation. gel diffusion analysis revealed that the a. veronii beta-hemolysin was serologically related to the a. hydrophila beta-hemolysin, a known enterotoxic molecule. the biological activity of the a. veronii hemolysin was neutralized b ...	1988	3143475
anatomic basis for the construction of a musculotendinous flap derived from the pectoralis major muscle.	the vascularization, innervation and termination of the clavicular portion of the pectoralis major muscle were studied by dissection of 7 adult subjects and 2 fetuses. the vascular and nervous autonomy of the clavicular portion was confirmed. blood-supply was effected by 2 arteries and innervation by an independent nerve. the exact distribution of the fibers composing the pectoralis major and their complex insertion are described. it is concluded that the clavicular portion can be employed as an ...	2011	3145568
using computers to take patient histories.		2011	3147730
non-immune igg f(ab')2 binding to group c and g streptococci is mediated by structures on gamma chains.	the present investigation was designed to determine whether the heavy or the light immunoglobulin chain is involved in the non-immune binding of igg f(ab')2 fragments to specific surface receptors on human group c and g streptococci. purified human polyclonal igg was mildly reduced with dithiothreitol and alkylated with iodoacetamide. light (l) and heavy (h) chains were separated. intact igg and purified l and h chains of polyclonal immunoglobulin g were tested in an inhibition assay for non-imm ...	1985	3156400
occupational pigmented contact dermatitis from azo-dyes.	a 51-year-old man had been working in a dye factory for 25 years and had noticed itching and pigmentation on the extremities for the past 5 years. patch testing showed positive reactions to sudan i and vacanceine red, among the azo dyes which he had been handling. after he changed his work, he became free from erythematous lesions with itching. the pigmentation almost disappeared 10 months later.	1985	3156714
stability of tonic vergence.	tonic vergence was monitored at 30 min intervals over a 10 hr period of a single day and at intervals of approximately 14 days over a period of 19 weeks. measurements were also made during a continuous 112 min period in total darkness. tonic vergence showed neither significant systematic variation nor large random fluctuations during the course of either a day or weeks, demonstrating stability under naturally occurring viewing conditions. during the period in total darkness, however, tonic verge ...	2011	3170129
[superior caliceal obstruction caused by vascular compression (fraley's syndrome)].		2011	3189028
[the body as hostage of the self. phenomenological aspects of anorexia nervosa].	there are several basic structures upon which anorexia nervosa could develop: hostility between mother and daughter, feministic protest, abandonnism, the ascetic structure, the reluctance against the being-thrown-on-the-world, asw. the phenomenological analysis reveals, through these different structures, a common distress. the patient feels the others, and also, the existence, as a violence. yet, she feels help ass in her fight against this violence. so she takes her own body as hostage in orde ...	1988	3207043
perforations of the tympanic membrane following the use of goode-type 'long term' tympanostomy tubes.	a retrospective review of 64 goode 't' tube insertions is presented. these were inserted into 61 ears of 48 patients over a period of four years. at the time of review of these 61 ears, 34 tubes were found to be in situ, 27 had extruded spontaneously and three had been removed surgically. ten ears in which the tube had been extruded or removed had central perforations of the tympanic membrane of which eight had been present for more than six months. the number of previous myringotomies or gromme ...	2011	3209952
sexual maturation of turkish boys in ankara.		1988	3232223
septicemia in adults at veterans general hospital. i. etiology and epidemiology.		2011	3242767
[a lipoma of the cerebellopontile angle].	the case of a 38-year old man with a lipoma of the left cerebellopontine angle is presented. while the clinical signs of that tumour are unspecific, an exact diagnosis is possible by ct and mri. as in other reported cases only an incomplete removal of the tumours was made because of the adherence of the lipoma to the nerves of the cpa.	1988	3261397
[a lipoma of the cerebellopontile angle].	the case of a 38-year old man with a lipoma of the left cerebellopontine angle is presented. while the clinical signs of that tumour are unspecific, an exact diagnosis is possible by ct and mri. as in other reported cases only an incomplete removal of the tumours was made because of the adherence of the lipoma to the nerves of the cpa.	1988	3261397
[properties of lak cell activity and lak-generation in pbl isolated from patients with renal cell carcinoma].		2012	3266646
clinical spectrum of primary empty sella turcica.	over recent years empty sella turcica has become more frequently diagnosed with high resolution computerized tomography and the associated clinical abnormalities have been better described. in this article the spectrum of clinical presentation is based on a review of 26 cases with six illustrative case reports. recommendations for management and further assessment are presented. it is important for clinicians to be aware of the varying presentations of this syndrome, since it should not be consi ...	2012	3270319
angiosarcomas of the skin.	angiosarcomas of the skin develop almost exclusively in the following clinical settings: (1) the lymphedematous extremity, secondary to prior mastectomy in most instances; (2) the face and scalp, usually in elderly individuals; and (3) skin that has been previously radiated. microscopically, there is a spectrum of architectural patterns. the best differentiated tumors exhibit obvious vascular spaces, which are lined by variably atypical endothelial cells, and that characteristically dissect betw ...	2011	3313596
are steroids essential for successful maintenance of immunosuppression in heart transplantation?	to determine the necessity for maintenance dosages of prednisone in the management of heart transplant patients, a retrospective study was made of 86 patients undergoing orthotopic heart transplantation and two patients having heart-lung transplantation from june 1985 through october 1986. group 1 (n = 52) had maintenance immunosuppressive therapy that included cyclosporine, azathioprine, and prednisone. group 2 (n = 36) received only cyclosporine and azathioprine with no maintenance dosage of s ...	2012	3316555
pancreatic burkitt lymphoma in aids: sonographic appearance.		2012	3318346
nabumetone in the treatment of active adult rheumatoid arthritis.	one hundred patients were entered in a six-month, double-blind comparison of 1,000 mg nabumetone once daily and 250 mg naproxen twice daily. forty-two patients in each arm of the study were evaluable for efficacy; all were evaluable for safety. there was a low incidence of adverse experiences during this study, with no patients withdrawing from the study because of side effects from either drug. efficacy was equal, with both compounds sharing the same degree and rate of improvement. all of the p ...	2012	3318429
[medico-genetic studies of human provisional organs].		1987	3318529
economic rights of the institutionalized mentally disabled.		2011	3319919
13c nmr studies of carboxylate inhibitor binding to cobalt(ii) carboxypeptidase a.	both 13c nmr and electronic absorption spectral studies on cobalt(ii) carboxypeptidase a in the presence of acetate and phenylacetate provide evidence for two binding sites for each of these agents. the transverse relaxation rate t2-1 for the 13c-enriched carboxyl groups of the inhibitors is significantly increased when bound to the paramagnetic cobalt carboxypeptidase as compared to the diamagnetic zinc enzyme. the acetate concentration dependence of t2p-1 shows two inflections indicative of se ...	2012	3346659
[development of home care in vorarlberg].		2012	3353111
coronary vascular actions of stroma-free hemoglobin preparations.	the left anterior descending coronary artery was cannulated in anesthetized, open-chest dogs for use as a coronary test bed to assess the coronary vascular actions of oxygenated, unmodified and pyridoxylated, partially cross-linked (polymerized), stroma-free hemoglobin solutions (sfhs). the actions of these sfhss were assessed in this test bed, by comparison with perfusion with whole blood. unmodified sfhs caused significant vasoconstriction, whereas pyridoxylated, partially polymerized sfhs did ...	1988	3355384
[choledochoduodenal anastomosis in benign lesions of the common bile duct].		2011	3358029
[choledochoduodenal anastomosis in benign lesions of the common bile duct].		2011	3358029
evaluation of prostaglandins as mediators of tubuloglomerular feedback.	orthograde and retrograde microperfusion experiments were conducted in sprague-dawley rats to evaluate the participation of vasoconstrictive eicosanoids as mediators of tubuloglomerular feedback (tgf) signals. retrograde perfusion with 160 microm arachidonic acid (aa) added to a hypotonic solution enhanced the stop-flow pressure (sfp) feedback responses compared with those obtained with the control hypotonic solution (delta sfp, 1.6 +/- 0.4 vs. 10.1 +/- 0.7 mmhg with aa). blockade of thromboxane ...	1988	3364575
have you looked at your will lately? seven common mistakes in estate planning and how to avoid them.		2012	3373137
biometeorological triggers in childhood asthma.	the relationship between child asthma admissions and biometeorological factors was investigated over a 16-month period. no relationship was found with many commonly suspected precipitants such as temperature, humidity and wind. there was however a strong association with rainfall (p much less than 0.001). associations occurred with low barometric pressure and counts of coloured basidiospores and green algae, but no significant relationship was found with grass pollen.	2012	3416418
revision total hip arthroplasty with titanium ingrowth prosthesis and bone grafting for failed cemented femoral component loosening.	fifty-seven hips (55 patients) had revision for failed cemented femoral component loosening using titanium ingrowth femoral components and cancellous bone grafting. the patients' average age was 59 years (range, 25-86 years), and the average follow-up period was 2.8 years (range, two to six years). the preoperative hip score averaged 45.5 (range, 10.0-80.7) and the postoperative hip score averaged 82.5 (range, 43.0-100.0). complications included dislocation (4.0%), infection (4.0%, one recurrenc ...	2012	3416518
orchiectomy during herniorrhaphy: what should we tell the patient?	although orchiectomy is rarely required during inguinal herniorrhaphy, it is frequently a topic of preoperative concern. our study disclosed a concomitant orchiectomy rate of 2 percent during 1,817 groin herniorrhaphies. the risk of orchiectomy was greatest in patients with incarceration (relative risk 22 times) but was also increased by herniorrhaphy for recurrence (relative risk 8 times) (table ii). on the other hand, patients undergoing repair of a primary reducible hernia were at low risk. o ...	2012	3425809
agoraphobia and parental bereavement.	the prevalence of parental bereavement was determined in 50 married female outpatients with a dsm-iii diagnosis of agoraphobia and in a control group of married female outpatients diagnosed as having non-psychotic psychiatric disorders other than agoraphobia. the two groups were matched for age and overall severity of psychiatric symptoms. compared with the general population, the patient control group reported a statistically significant excess of parental, but not maternal, bereavement. the ag ...	2012	3435374
[the postcholecystectomy syndrome].		2012	3454415
a word about words.		2012	3459834
[dynamic study of the excretion of urinary fluoride induced by fluoridated tooth paste].		2012	3463490
mouth opening after release of maxillomandibular fixation in fracture patients.	three hundred eleven patients with mandibular fractures were studied prospectively to ascertain the influence of jaw immobilization on mouth opening. maxillomandibular fixation caused a significant reduction in mouth opening whereas open reduction did not. furthermore, there appeared to be a relationship between the duration of immobilization and the degree of reduction of mouth opening such that the shorter the duration of fixation, the less the reduction.	2012	3471923
case-control study on histologically determined multiple primary lung cancer.	between 1965 and 1985, 72 (64 male and 8 female) cases of multiple primary lung cancer (mplc) in the national cancer center hospital, japan, were reviewed, and a retrospective hospital-based case-control study was performed with special reference to the patients' smoking and family histories. control cases were selected from patients with unicentric lung cancer (ulc) with a longer survival time than that for other patients with whom they were matched for age, sex, histologic examination of prima ...	2008	3476786
a procedure of vestibular decompensation for clinical diagnosis. i. animal experiments.	vestibular lesions are often so effectively compensated that their diagnosis may be difficult. certain chemicals can decompensate the central vestibular system and thus uncover symptoms present before compensation. this study attempts to devise a procedure which can utilize such decompensation for the benefit of clinical diagnosis. unilateral labyrinthectomies were performed in rats. pathological movements and body positions due to the vestibular loss were compensated within about one week. syst ...	1986	3485723
[liver function in patients with chronic ischemic heart disease combined with peptic ulcer].		2012	3493589
[value of the simultaneous determination of alpha-amylase and pancreatic lipase for the diagnosis of attacks of acute pancreatitis].		2010	3494288
[value of the simultaneous determination of alpha-amylase and pancreatic lipase for the diagnosis of attacks of acute pancreatitis].		2010	3494288
trimethoprim used for selective decontamination of the digestive tract in rats: possible route of excretion.	selective elimination of enterobacteriaceae species from the digestive tract of rats has been accomplished by oral treatment with trimethoprim (235 mg/kg body weight/day) within 6 days. in the present study it was investigated whether this elimination was mainly due to antimicrobial activity of trimethoprim excreted with the gastrointestinal mucus or mainly by non-absorbed trimethoprim in the lumen contents. by means of whole gut irrigation (wgi) the lumen contents were washed out, followed by m ...	1987	3497436
[determining the functional stability of the equilibrium system based on its static and dynamic characteristics].		2012	3497478
[individual preventive examinations of school-age children accompanied by their parents].		2012	3502955
historic insights on dental radiography.		2012	3516271
pharmacotherapy in alzheimer's disease: basis and rationale.	alzheimer's disease is a slowly progressive disorder involving deterioration of both intellect and personality. the neuropathological features of alzheimer's disease include abundant neurocortical senile plaques and neurofibrillary tangles. drug therapies of alzheimer's disease have been based on empirical observations of the signs and symptoms of the disease and have included the use of hypnotics to reverse insomnia or inverse sleep rhythms; anxiolytics to relieve anxiety, tension and restlessn ...	2012	3541049
clinical overview of alpha interferon. studies and future directions.	the clinical development of the alpha interferons has now progressed through initial phase i and ii trials into extensive controlled clinical trial designs. alpha interferon has been a prototype of other biological agents that are now in clinical development. these agents operate through fundamentally different mechanisms of action than conventional chemotherapy and have produced a unique profile of side effects as well as response patterns. time to response is generally longer than with chemoth ...	2013	3542185
[therapeutic and corrective work with stammering preschool children in a daytime semi-hospital].	therapeutic and corrective work with stammering preschool children conducted at a day-time semi-hospital institution presents a complex of measures aimed at improving the speech and the entire psychic activity of the child. a semi-hospital form of the organization makes it possible, along with therapeutic and corrective measures, to constantly train the speech in the most diverse situations of the microsocial environment outside the hospital and thus contributes to the development of social and ...	2012	3544614
a practicable variant of the ion exchange method for the radiometric estimation of ornithine decarboxylase activity.	a known ornithine decarboxylase assay working with ion exchange separation of [3h]ornithine and [3h]putrescine has been revised. the assay can be performed in disposable 1.5 ml vessels with a total of four pipetting steps. the separation of enzyme substrate and product, respectively, requires 3 h per 50 samples. the detection limit is about 50 pmoles [3h]putrescine formed.	1987	3545892
fetal-type creatine kinase in rat fast and slow muscles during denervation and reinnervation.	creatine kinase (ck) has three forms of isozymes; ck-bb, ck-mb, and ck-mm. in adult rats they show a specific tissue distribution: the bb form in the brain, the mb form in the heart, and the mm form in skeletal muscle. in embryonic skeletal muscles only the bb and mb forms are found. adult slow-twitch muscles contain more fetal type creatine kinase (ck-b) than do fast-twitch muscles. in the present experiment the effect of denervation and reinnervation on the ck-b concentration was investigated ...	1987	3556205
fetal-type creatine kinase in rat fast and slow muscles during denervation and reinnervation.	creatine kinase (ck) has three forms of isozymes; ck-bb, ck-mb, and ck-mm. in adult rats they show a specific tissue distribution: the bb form in the brain, the mb form in the heart, and the mm form in skeletal muscle. in embryonic skeletal muscles only the bb and mb forms are found. adult slow-twitch muscles contain more fetal type creatine kinase (ck-b) than do fast-twitch muscles. in the present experiment the effect of denervation and reinnervation on the ck-b concentration was investigated ...	1987	3556205
electrophysiological effects of mexiletine in patients of sinus node dysfunction and intraventricular conduction defects.		2012	3557516
electrophysiological effects of mexiletine in patients of sinus node dysfunction and intraventricular conduction defects.		2012	3557516
aeromonas veronii, a new ornithine decarboxylase-positive species that may cause diarrhea.	in 1983, the vernacular name enteric group 77 was coined for a group of strains that had been referred to our laboratory as "possible vibrio cholerae except for gas production." by dna-dna hybridization (hydroxyapatite, 32p), 8 of 10 strains of enteric group 77 were very highly related to the labeled strain 1169-83 (74 to 100% at 60 degrees c and 75 to 100% at 75 degrees c; percent divergence, 0.0 to 2.5). type strains of six other aeromonas species were 45 to 66% related (60 degrees c) to strai ...	1987	3584425
atlanta's homeless find health care.		2013	3636083
[understanding of the basic needs of a patient with difficulty in communication and his nursing care].		2013	3638456
thermodynamics of spectroelectrochemical electron transfer in a mesotetra sulphonated phenyl porphyrin iron(iii)-apomyoglobin complex.		2013	3666778
[effects of inosine on the transmembrane potential and contractility of the hypoxic cardiac muscle].		1987	3686054
deer slaughter.		2013	3705401
inhibition of liver glutathione s-transferase activity in rats by hypolipidemic drugs related or unrelated to clofibrate.	the effects of in vivo administration of six hypolipidemic drugs on rat liver glutathione s-transferase activity were compared. this activity was measured with sulfobromophthalein (bsp), 1,2-dichloro-4-nitrobenzene (dcnb) or 1-chloro-2,4-dinitrobenzene (cdnb) as substrate. except for the nicotinic acid derivative ethanolamine oxiniacate, all the compounds tested significantly reduced it, whether or not they were related to clofibrate. the hepatic glutathione concentration either remained unchang ...	1986	3707598
three permutations of percutaneous endoscopic gastrostomy.		2013	3710099
[esophageal scintigraphy and ph measurement in asthmatic adults suspected of having gastroesophageal reflux].	fifty-five adults with asthma were explored by gastroesophageal scintigraphy (ges) and ph monitoring (3 postprandial hours, 12 nocturnal hours). for their asthma, all patients received theophylline twice a day. associated digestive symptomatology led to investigations for gastroesophageal reflux (ger). twelve hours ph monitoring, the reference method, was validated in 13 normal volunteers. during 12 hr ph monitoring, 4 criteria were studied: number of ger, percentage of time at ph 4, number of g ...	2012	3732745
disproportional changes in the rates of biliary bile acid, phospholipid and cholesterol secretion in the shr/n-corpulent rat.	lean and obese male rats of the shr/n-cp strain were fed a plain chow diet ad libitum and studied at 11-13 weeks of age. compared to their lean littermates the obese animals manifested 2-4-fold higher plasma levels of cholesterol, triacylglycerol and glucose. in the obese rats, the mass of the liver was increased more than 70% and there was a significant increase in the total hepatic content of free cholesterol (42%), cholesteryl ester (2.9-fold) and triacylglycerol (7.4-fold). despite the diffe ...	1986	3768384
effect of dilauroylphosphatidylcholine on the acrosome reaction and subsequent penetration of bull spermatozoa into zona-free hamster eggs.	incubation of bull sperm with liposomes made with phosphatidylcholine (pc) containing fatty acyl chains of either 10 (pc10) or 12 (pc12) carbons resulted in greater than 90% of the sperm exhibiting an acrosome reaction (ar) within 15 min. liposomes of pc10 rapidly destroyed sperm motility while pc12 acrosome-reacted sperm remained motile for several h. liposomes of pc with greater than or equal to 14-carbon fatty acyl chains had no effect on the ar or motility of sperm. the ar was not induced by ...	1986	3768462
malignant melanoma.		2010	3768643
[soft tissue tumors (review of differential diagnosis)].		2012	3768999
monitoring of long-term motor activity in depressed patients.	wrist motor activity was continuously recorded by a solid-state monitor in 12 patients with major depression throughout their stay in hospital; their clinical state was evaluated using three scales. during the day, activity troughs and immobility peaks occurred before noon and around 1500 hrs. activity level progressively increased, while the duration of immobility decreased, with clinical improvement. the immobility measurement appeared to be a valuable index of depression and is more sensitive ...	2013	3779292
microsomal binding sites for antioestrogens in rat liver. properties and detergent solubilization.	the properties of an antioestrogen binding site (aebs), which has high affinity and specificity for nonsteroidal antioestrogens and structurally related compounds, have been studied in rat liver microsomes. when subcellular organelles were separated on percoll density gradients the distribution of the aebs paralleled that of nadph-cytochrome c reductase, indicating that the aebs is associated with the endoplasmic reticulum. saturation analysis showed that [3h]tamoxifen was bound to a single clas ...	1986	3790095
relationship between amino acid composition of diet and plasma cholesterol level in growing rats fed a high cholesterol diet.	the effects of dietary sulfur-containing amino acids and glycine on plasma cholesterol level were studied in rats fed amino acid mixture diets containing cholesterol. the relationship between the amino acid composition of dietary proteins and plasma cholesterol levels was also investigated in rats fed diets containing various kinds of protein such as casein, egg albumin, pork protein, fish protein, corn gluten, wheat gluten and soy protein. feeding the amino acid mixture corresponding to casein ...	1986	3806255
the cutting diathermy and drain tracts.		2013	3810377
[intravital acellular hemolysis of extravascular erythrocytes. an experimental contribution to the determination of wound age].	the time-dependent acellular, destructive changes in erythrocytes was investigated in rabbits by subcutaneous, intraperitoneal, and subdural implantation of blood-filled diffusion chambers with 0.45 micron pores. the animals were killed at various intervals after implantation (7-24 h), and the erythrocytes in the capsules were examined by light and electron microscopy. the findings were quantified by counting 100 cells per preparation under the light microscope; changes in both matrix and membra ...	1986	3811629
cervical lymph node metastases with occult primary.	patients with cervical metastases from an unknown primary tumour present both diagnostic and therapeutic problems. twenty patients with a metastatic lesion in the neck, in whom the primary tumour was not found despite extensive, diagnostic procedures, were treated in the department of otolaryngology, linköping university hospital, during a 14-year period (1971-1984). since 1975 tonsillectomy has been performed regularly on the affected side as a part of the diagnostic procedure. eight patients w ...	2012	3815873
the march of time: rigid or chaotic transactions, two different ways of living time.	in this paper the author shows that families do not live time in the same way. in families with rigid transactions, time is arrested; in families with chaotic transactions time is eventful. these different ways of living time are true of all systems, and parallels are drawn with political systems. therapists must thus manage the therapeutic time in different ways, and this depends, among other factors, on their "personal equation." to achieve this, some guidelines are given, and two techniques t ...	2013	3817128
[effect of titanium phosphate, zirconium oxide and a mixture of ammonium phosphotungstenate with zirconium phosphate on the elimination of radioactive cesium from the bodies of rats].		1985	3835674