Publications

aeromonas sobria spontaneous bacterial peritonitis.		1992	1449170
ultrastructural alterations of brain cortex in rat following intraperitoneal administration of mercuric chloride.	intraperitoneal administration of a single dose (6 mg/kg body weight) of mercuric chloride (hgcl2) results in ultrastructural changes in brain cortex of the rats. 18 hours after administration of hgcl2 the accumulation of dense deposits of mercury in nerve and glial cell cytoplasm was observed. the quantity of microglia in neuropil was also increased in this experimental group. we postulate that these cerebral macrophages can play an important role in the process of intoxication, too. 5 days aft ...	1992	1479187
[late onset serum iga and igm deficiency revealed by acute diarrhea caused by aeromonas sobria infection].		1992	1526403
memory and anergy: challenges to traditional models of t lymphocyte differentiation.	traditional paradigms suggest that encounter with an antigen converts naive peripheral t cells into memory cells with less stringent requirements for activation and increased capacities for lymphokine production. recent evidence argues that this view may be over-simplified in two ways. first, an encounter with antigen in the absence of certain costimulatory factors can render a t cell anergic--that is, unable to respond to antigen under normal conditions. second, although cells of the memory t c ...	2006	1563595
enterotoxic effects of aeromonas sobria haemolysin in a rat jejunal perfusion system identified by specific neutralization with a monoclonal antibody.	investigations into the pathogenesis of aeromonas diarrhoea have demonstrated that several different cell-free products of motile aeromonads show enterotoxic activity in suckling mouse, rat, and rabbit assay systems. the relative contributions made by separate cytotoxic and cytotonic activities in the mixture produced by in vitro culture remains unresolved. using a modified rat jejunal perfusion assay, we have studied the effects of a. sobria culture filtrates containing defined levels of haemol ...	1992	1564437
molecular studies on the aerolysin gene of aeromonas species and discovery of a species-specific probe for aeromonas trota species nova.	a large group of aeromonads and other enteric microorganisms were assayed for the presence of the aerolysin gene with use of dna-dna hybridization. two dna fragments corresponding to the regulatory region (aerc) and the structural gene (aera) were used as probes for the detection of the aerolysin gene in these strains. sequences corresponding to the aerolysin structural gene were widespread among aeromonas isolates. in contrast, the aerc probe was much more selective, and sequences corresponding ...	1992	1600007
[the occurrence of aeromonads in a drinking water supply system].	this study concerns with the occurrence of aeromonads, coliforms and colony counts in a drinking water supply. aeromonas contents were detected in the range of 15.0 to greater than 2,400/100 ml in the raw water samples of the man made lake. after the drinking water treatment process including fast sand filtration and chlorination aeromonads indicated in comparison to total coliforms and colony counts early and significant an after-growth of maximal 240 aeromonads/100 ml in the peripheric drinkin ...	1992	1609555
rapid detection of members of the family enterobacteriaceae by a monoclonal antibody.	six monoclonal antibodies directed against enterobacteria were produced and characterized. the specificity of one of these antibodies (cx9/15; immunoglobulin g2a) was studied by indirect immunofluorescence against 259 enterobacterial strains and 125 other gram-negative bacteria. all of the enterobacteria were specifically recognized, the only exception being erwinia chrysanthemi (one strain tested). bacteria not belonging to members of the family enterobacteriaceae were not detected, except for ...	1992	1622220
application of ribotyping for differentiating aeromonads isolated from clinical and environmental sources.	we have investigated the usefulness of ribotyping for the differentiation of aeromonads isolated from five patients with gastroenteritis and from the source water, treatment plant, and distribution system of a small public water supply. aeromonas hydrophila and aeromonas caviae were isolated from fecal specimens preserved in cary-blair transport medium by using blood ampicillin agar or alkaline peptone water (ph 8.4) subcultured to blood ampicillin agar plates. a. hydrophila, aeromonas sobria, a ...	1992	1622269
[a just pension system].		2006	1636316
purification and characterization of aeromonas sobria pili, a possible colonization factor.	pili of aeromonas sobria ae1 were purified and characterized. the molecular mass of the pilin was estimated to be about 23 kda by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. the ae1 pili were electrophoretically and immunologically distinguishable from the w pili of a. hydrophila ae6, although the two pili were morphologically indistinguishable. the n-terminal amino acid sequences of the two pilins were identical in the first 10 residues. strain ae1 and its purified pili adhered t ...	1991	1680105
aerolysin of aeromonas sobria: evidence for formation of ion-permeable channels and comparison with alpha-toxin of staphylococcus aureus.	aerolysin from aeromonas sobria ab3 was isolated and purified. the pure toxin formed sodium dodecyl sulfate-insoluble oligomers in a lipidic environment. the addition of aerolysin to the aqueous phase bathing lipid bilayer membranes resulted in the formation of ion-permeable channels which had a single-channel conductance of about 70 ps in 0.1 m kcl. this defines the toxin as a channel-forming component similar to other toxins but without any indication for an association-dissociation reaction, ...	1990	1694819
uptake and retrograde transport of [3h]gaba from the cochlear nucleus to the superior olive in the guinea pig.	the purpose of the present study is to determine which descending projections to the cochlear nucleus may use gamma-aminobutyric acid (gaba) as a neurotransmitter. [3h]gaba (120 microm) was injected into the cochlear nucleus of albino and pigmented guinea pigs. after survival times between 0.25 and 16 h, the brain stems were prepared for light microscopic autoradiography. after 2 h survival there was a pulse of label, which progressed through the fibres from the cochlear nucleus to the ipsilater ...	1990	1697753
binding of laminin and fibronectin by the trypsin-resistant major structural domain of the crystalline virulence surface array protein of aeromonas salmonicida.	the surface of aeromonas salmonicida is covered by a tetragonal paracrystalline array (a-layer) composed of a single protein (a-protein, mr = 50,778). this array is a virulence factor. cells containing a-layer and isolated a-layer sheets specifically bound laminin and fibronectin with high affinity. binding by cells was inactivated by selective removal of a-layer at ph 2.2, and neither isogenic a-layer-deficient a. salmonicida mutants nor tetragonal paracrystalline array producing aeromonas hydr ...	1992	1730607
[points of view on mechanisms of cardiac arrhythmias].		2005	1770585
structure of the rabbit phospholamban gene, cloning of the human cdna, and assignment of the gene to human chromosome 6.	we have isolated and characterized genomic dna clones encoding rabbit phospholamban. only a single gene for phospholamban was detected in the rabbit genome. the phospholamban gene of 13.2 kilobases contains only one 10.5-kilobase intron, which separates exonic sequences located in the 5'-untranslated region. two potential transcription initiation sites were mapped to 335 and 185 nucleotides upstream from the translation initiation site in the mrna or 239 and 89 nucleotides upstream from the exon ...	1991	1828805
growth of and toxin production by aeromonas hydrophila and aeromonas sobria at low temperatures.	the effects of different temperatures on the growth and toxin production of aeromonas hydrophila and aeromonas sobria were studied. the results showed that these aeromonas species are not only able to grow at low temperatures (e.g. at 4 and 10 degrees c) but may also produce cytotoxin, hemolysin and enterotoxin under suitable growth conditions.	1991	1888660
[severe occurrence of idiopathic ulcerative colitis caused by aeromonas sobria].		1991	1910924
aeromonas hydrophila: variability in biochemical characteristics of environmental isolates.	a total of 161 strains, including 144 aeromonads, of which 100 had been isolated from water and sediment samples from the chesapeake bay, five clinical and 33 anacostia river isolates of aeromonas hydrophila, six aeromonas sobria, and ten reference cultures were examined in a numerical taxonomy study in which each of the strains were examined for 56 unit characters. similarity between strains was computed using the simple matching (ssm) and jaccard (sj) coefficients. the strains were clustered b ...	1991	1920081
gas-liquid chromatographic analysis of cellular fatty acid methyl esters in aeromonas species.	the cellular fatty acids of 39 strains belonging to the genus aeromonas (aeromonas hydrophila, aeromonas caviae, aeromonas sobria, aeromonas media, aeromonas schubertii, aeromonas veronii) were determined by high resolution gas-liquid chromatography. the fatty acid profiles were characterized by major amounts (60% or more) of one saturated (hexadecanoic acid = 16:0) and two unsaturated (hexadecenoic acid = 16:1 and octadecenoic acid = 18:1) acids. while the majority of the strains of the six spe ...	1991	1930556
a positive fever response in agama agama and sceloporus orcutti (reptilia: agamidae and iguanidae).	three species of lizards (agama agama, mabuya perrotetii, and sceloporus orcutti) were tested for a possible increase in mean selected body temperature (msbt) in response to intraperitoneal injection of alcohol-killed aeromonas sobria, a gram-negative bacterium known to be pathogenic to reptiles. a paired experimental design was utilized in which each animal was given an injection of sterile saline and 1.10(10) a. sobria. body temperatures were monitored via indwelling cloacal thermocouples at 4 ...	1991	1939744
intestinal secretory immune response to infection with aeromonas species and plesiomonas shigelloides among students from the united states in mexico.	intestinal secretory iga (siga) response or lack of response among adults in mexico with diarrhea was used as an indicator of enteropathogenicity of aeromonas species and plesiomonas shigelloides. siga was extracted from stool specimens obtained at day of presentation and 5 days later. total siga was standardized, and specific siga titer against the organism being shed by each patient was determined. western blotting was used to determine which microbial antigens elicited an intestinal siga resp ...	1991	1940478
effect of bacterial pyrogen on three lizard species.	1. three lizard species (callopistes maculatus, gerrhosaurus major, and varanus exanthematicus) were tested for their response to intraperitoneal injection of alcohol-killed aeromonas sobria. 2. a paired experimental design, in which each animal received an injection of sterile saline and 1 x 10(10) a. sobria, was utilized. 3. c. maculatus demonstrated a statistically significant increase in mean selected body temperature (msbt) after bacteria injection. 4. g. major and v. exanthematicus did not ...	1990	1976479
biochemical and genetic characterization of autoagglutinating phenotypes of aeromonas species associated with invasive and noninvasive disease.	the genetic characteristics and biochemical and structural properties of a number of autoagglutinating (aa) strains of aeromonas associated with invasive and noninvasive disease in humans and infections in animals and from environmental sources were investigated. of 27 strains analyzed by multilocus enzyme typing and dna hybridization studies, 25 (93%) were confirmed to belong to either hybridization group 1 (phenospecies and genospecies aeromonas hydrophila) or 8 (phenospecies aeromonas sobria; ...	1991	2010642
experimental evidence for toxin production by aeromonas hydrophila and aeromonas sobria in a meat extract at low temperatures.	the ability of enterotoxigenic strains of aeromonas hydrophila and aeromonas sobria to produce exotoxins (enterotoxin and haemolysin) in a meat extract at low temperatures (5 and 12 degrees c) was investigated. all three strains incubated at 12 degrees c were enterotoxigenic and haemolytic in the meat extract after 5 days. at 5 degrees c, five of the six strains tested were able to produce these exotoxins after 8 days incubation while one strain was neither enterotoxigenic nor haemolytic after 5 ...	1991	2049284
evaluation of the antimicrobial activity of methylglyoxal bis(guanylhydrazone) analogues, the inhibitors for polyamine biosynthetic pathway.	metabolic and antiproliferative effects of methylglyoxal bis(butylamidinohydrazone) (mgbb) and methylglyoxal bis(cyclopentylamidinohydrazone) (mgbcp), inhibitors for polyamine biosynthetic pathway, on escherichia coli, shigella sonnei, aeromonas sobria, aeromonas hydrophila and vibrio cholerae were investigated. mgbb at the concentration of 100 mumol/l depleted intracellular putrescine and spermidine concentrations of e. coli to 25 and 20% of the controls, respectively, while mgbcp depressed the ...	1991	2055790
aeromonas spp. and their association with human diarrheal disease.	between january 1988 and december 1989 aeromonas species were isolated from 45 (1.8%) of 2,480 patients with acute gastroenteritis. no other bacterial enteric pathogens were found in any of these 45 patients. of the 45 aeromonas isolates, 35 strains (77.8%) were aeromonas hydrophila, 7 (15.5%) were aeromonas sobria, and 3 (6.7%) were aeromonas caviae. most of the patients were under 5 years of age. no bacterial enteric pathogens, including aeromonas species, were isolated from 512 age- and sex-m ...	1991	2056050
haemolysin occurrence among aeromonas hydrophila, aeromonas caviae and aeromonas sobria strains isolated from different aquatic ecosystems.	a total of 909 aeromonas spp. isolates from different aquatic ecosystems were tested for haemolysin production by both sheep and horse blood agar-plate assays and by rabbit erythrocytes in broth assay. a comparison of these different methods was undertaken in order to appreciate their capacity to evaluate the haemolytic activity of aeromonas spp. isolated from aquatic ecosystems. the haemolytic activity was associated particularly with a. hydrophila and a. sobria (about 95% of strains), whereas ...	1991	2068383
analysis of the autoagglutination phenomenon, serogroup and hydrophobicity as virulence markers in mesophilic aeromonads isolated from stool cultures.	the autoagglutination phenomenon (aa) was studied in 71 strains of mesophilic aeromonads isolated from stool cultures of patients with acute diarrhea (28 aeromonas hydrophila, 20 aeromonas sobria, and 23 aeromonas caviae). two phenotypes were considered in the aa+ strains: sp+ (self-pelleting) and pab+ (precipitation after boiling). serogrouping of the strains was performed only with the 0:11 serum. other properties studied were agglutination with acriflavine (acr) and crystal violet uptake (cvb ...	1990	2073902
[new enteropathogens: aeromonas spp].	aeromonas is one of the type of enteric pathogens which is commonly present in less developed countries. it leads to acute diarrhea in children and traveller's diarrhea in adults. additionally it is also responsible from the extraintestinal infections. aeromonas hydrophila is a bacteria which is isolated from water, soil, foods and rarely from intestinal tract of human. aeromonas sobria is especially isolated from wound infection of scuba diver's. there are other types of aeromonas such as salmo ...	1990	2089235
spinal cord repair: is tissue oxygenation an important variable?	we have demonstrated the reliability and feasibility of making pto2 recordings from graft and host tissue in the injured spinal cord. the data suggest that the oxygen microenvironment of developing graft and host spinal tissue is clearly different from that found in normal spinal tissue or in transplants that have not survived or integrated well. these same constraints seem to apply to cavitation in developing grafts and poorly developed graft/host interfaces. the similarity between these findin ...	1990	2096642
[spectroscopy of the liver in vivo using nuclear magnetic resonance. a new approach in hepatic physiopathology].	nuclear magnetic resonance (nmr) spectroscopy is a non-invasive means of detecting numerous compounds, thus enabling real-time studies to be carried out on such topics as energy metabolism, intracellular ph and main intermediate metabolism pathways. this method has been used for several years to study perfused livers and rat livers in vivo, but its application to man has just begun. we describe some of its principal uses, with emphasis on the possibilities it offers to investigate the metabolic ...	1990	2140172
induction of ornithine decarboxylase mrna in cerebral cortex in response to lesion of nucleus basalis.		1990	2164982
rapid presumptive phenospecies identification of mesophilic aeromonads by testing for suicidal activity.	a new test combination for presumptive phenospecies identification of mesophilic aeromonads by testing for suicidal activity in conjunction with esculin hydrolysis and gas production from glucose was evaluated. of 40 clinical isolates of aeromonas tested statically at 30 degrees c, seven were identified as aeromonas hydrophilia (non-suicidal, aerogenic, esculin positive), eight as aeromonas sobria (suicide variable, mostly aerogenic, esculin negative), and 25 as aeromonas caviae (suicidal, anaer ...	1990	2209629
the incidence of virulence factors in mesophilic aeromonas species isolated from farm animals and their environment.	sixty-one isolates of aeromonas spp. from the faeces of pigs, cows and a variety of associated environmental sources were examined for the characteristics that are reputed to have roles in pathogenicity. most isolates of aeromonas hydrophila were cytotoxic (96.4%) and were capable of producing cell elongation factor (75%) and haemagglutinins (67.9%). in contrast few of the aeromonas caviae isolates produced these three markers (13.6%, 27.3% and 36.4% respectively). in general, aeromonas sobria o ...	1990	2209733
electrophoretic analysis of the surface components of autoagglutinating surface array protein-positive and surface array protein-negative aeromonas hydrophila and aeromonas sobria.	the protein and lipopolysaccharide (lps) compositions of 10 autoagglutinating aeromonas hydrophila and aeromonas sobria strains were studied; one group consisted of five serogroup o:11 strains that contained an s layer, while a second group was composed of diverse serogroups that were s layer negative by transmission electron microscopy. all serogroup o:11 strains were found to contain a predominant 52,000- to 54,000-molecular-weight protein that was present on both whole-cell and outer membrane ...	1990	2229347
cytostatic and cytotoxic effects of recombinant tumor necrosis factor-alpha on sensitive human melanoma cells in vitro may result in selection of cells with enhanced markers of malignancy.	monolayer cultures of the human melanoma cell lines stml-12, stml-11, stml-14 (third, respectively, twenty-fifth subculture), and skmel-28 derived from specimens representing different stages of tumor progression were treated with 10-10,000 u/ml rtnf-alpha applied for 72 h. the effects of rtnf-alpha on cell proliferation, dna synthesis, cell viability, cloning efficiency, cell division, cell morphology, and the immunophenotype were studied in triplicate experiments. the cell line stml-14(3) reve ...	1990	2258639
cytostatic and cytotoxic effects of recombinant tumor necrosis factor-alpha on sensitive human melanoma cells in vitro may result in selection of cells with enhanced markers of malignancy.	monolayer cultures of the human melanoma cell lines stml-12, stml-11, stml-14 (third, respectively, twenty-fifth subculture), and skmel-28 derived from specimens representing different stages of tumor progression were treated with 10-10,000 u/ml rtnf-alpha applied for 72 h. the effects of rtnf-alpha on cell proliferation, dna synthesis, cell viability, cloning efficiency, cell division, cell morphology, and the immunophenotype were studied in triplicate experiments. the cell line stml-14(3) reve ...	1990	2258639
mediator and cellular mechanisms in asthma. the philip ellman lecture 1990.		2007	2258848
direct selection of monoclonal antibodies neutralising the cytotoxic activity of aeromonas sobria.	monoclonal antibodies directed against the cytotoxic activity of aeromonas sobria were raised by immunising mice with a culture supernatant concentrated by ammonium sulphate precipitation. neutralising antibodies were specifically selected for by exposing hybridomas to cytotoxic levels of the immunising preparation. cultures free from cytopathic effects after three hours were selected for further investigation. ten cytotoxin resistant hybridomas were isolated but only two of these produced detec ...	1990	2272497
mechanisms of inhibition of various cellular dna and rna polymerases by several flavonoids.	four flavonoids (i.e., baicalein, quercetin, quercetagetin, and myricetin), known to be inhibitors of hiv-reverse transcriptase, have been shown to be more or less inhibitory to the activities of various cellular dna and rna polymerases. the degree of the inhibition varied depending on the combination of the flavonoid and the enzyme species: baicalein was moderately inhibitory to dna polymerase gamma and e. coli dna polymerase i; quercetin was strongly inhibitory to dna polymerase beta and e. co ...	1990	2292590
assay of all-trans----11-cis-retinoid isomerase activity in bovine retinal pigment epithelium.		1990	2292965
pathogenicity factors and virulence for rainbow trout (salmo gairdneri) of motile aeromonas spp. isolated from a river.	ninety-seven motile aeromonas strains were isolated over a period of a year from samples of water and sediment collected at different sites along a river. strains were regularly recovered from all samples, regardless of the source of isolation or seasonal conditions. isolates were biochemically characterized by the api 20ne system (analytab products, plainview, n.y.) and classified as aeromonas hydrophila (74 strains), aeromonas sobria (11 strains), and aeromonas caviae (12 strains). despite the ...	1990	2312678
pyrazinamidase activity as a phenotypic marker for several aeromonas spp. isolated from clinical specimens.	negative pyrazinamidase activity was significantly associated with aeromonas sobria, and positive pyrazinamidase activity was associated with a. hydrophila and a. caviae (chi 2, p less than 0.0001). the absence of pyrazinamidase activity may be a potentially significant phenotypic marker for a. sobria.	1990	2312687
aeromonas sobria in bubaline (water buffalo) abortion: growth requirement, biochemical characters, antibiotic susceptibility, experimental pathogenicity and serology.	a. sobria was isolated unexpectedly on campylobacter selective medium from abortion specimens of 16 buffaloes. all strains (as1-as16) required campylobacter growth supplement (sodium pyruvate, sodium metabisulphate and ferrous sulphate) and 10% c02 atmosphere on primary isolation. they were unusually sensitive to bile salt and failed to grow on macconkey's agar. biochemically, these strains were homogeneous but antibiogram profile and physiological/other characters revealed a moderate heterogene ...	1990	2351419
microbiologic and clinical evidence supporting the role of aeromonas caviae as a pediatric enteric pathogen.	aeromonas caviae was recovered as the sole potential enteric pathogen from the stools of 14 of 17 symptomatic children (10 younger than 1 year of age) while aeromonas hydrophila, aeromonas sobria, and plesiomonas shigelloides were isolated once each. the infants from whom a. caviae was isolated all presented with a watery diarrhea lasting 1 to 3 weeks. none of these infants was breast-fed, and all had a stool ph of greater than 7.5. all of the a. caviae isolates, including a reference strain (at ...	1990	2351730
isolation of aeromonas spp. from canal water.	aeromonas sobria was identified from soil and canal water at the east end of london. there was a correlation between water and faecal isolates from children attending the nearby children's hospital. in view of the potential risk of enteric and non-enteric infections due to aeromonas spp, efforts are needed to ensure that canals, rivers, natural water sources and domestic water supply are free of these organisms.	1990	2361702
in vitro susceptibility of aeromonas caviae, aeromonas hydrophila and aeromonas sobria to fifteen antibacterial agents.	in vitro testing of the activity of 15 antibacterial agents against 522 clinical isolates of aeromonas species demonstrated some species-associated trends. amoxicillin plus clavulanic acid was effective against approximately 45% of aeromonas caviae and aeromonas hydrophila, but all aeromonas sobria isolates were resistant. aztreonam, piperacillin and mezlocillin were highly active against all the strains of aeromonas tested. ticarcillin was equally effective against aeromonas caviae and aeromona ...	1990	2387294
dynamics of aeromonas hydrophila, aeromonas sobria, and aeromonas caviae in a sewage treatment pond.	the spatiotemporal dynamics of aeromonas spp. and fecal coliforms in the sewage treatment ponds of an urban wastewater center were studied after 20 months of sampling from five stations in these ponds. isolation and identification of 247 aeromonas strains were undertaken over four seasons at the inflow and outflow of this pond system. the hemolytic activity of these strains was determined. the aeromonas spp. and the fecal coliform distributions showed seasonal cycles, the amplitude of which incr ...	1990	2389929
whole-body autoradiography of [3h]dihydrostreptomycin in guinea pigs and rats: the labelling of the inner ear in relation to other tissues.	[3h]dihydrostreptomycin was given intramuscularly to young pigmented guinea pigs and rats. whole-body autoradiography, combined with densitometric measurement of the blackening of the autoradiograms, and liquid scintillation counting were used to determine the levels of radioactivity in the inner ear in relation to blood and other tissues. it was found that there was an accumulation of radioactivity in the perilymph of both the cochlear and vestibular parts of the labyrinth. the labelling of the ...	1986	2422870
cystic neoplasms of the pancreas.	eight patients with cystic neoplasms of the pancreas were seen at four northern california hospitals between the years 1978 and 1986. three of the tumors were benign and five were malignant. three females, whose average age was 61 years, had cystadenomas. three females and two males, whose average age was 48 years, had mucinous cystadenocarcinomas. clinical presentations were similar among all patients. abdominal pain was a prominent feature. anorexia, weight loss, nausea and vomiting with a pal ...	2008	2446398
nucleotide sequence and transcriptional analysis of the aercaera region of aeromonas sobria encoding aerolysin and its regulatory region.	the nucleotide sequence of a 2510 base pair chromosomal fragment containing the aerolysin gene aera, and its regulatory region aerc, from a clinical isolate of aeromonas sobria was determined. the aerolysin gene coded for a 54.5 kd polypeptide and had a g + c content of 59%, indicating that it is endogenous to the genus aeromonas. in contrast, the aerc region was characterized by its high a + t content (61%) and the presence of a core motif, aataaaa, repeated eight times within 300 base pairs. a ...	1988	2459581
production and characterization of monoclonal antibodies to aeromonas sobria surface antigens.	a panel of eight murine monoclonal antibodies (mabs) was raised against the surface antigens of aeromonas sobria isolated from a patient with diarrhoea. antibodies to the lps core and o-antigen and to protein antigens were generated. three mabs of the igm isotype against either protein or lps agglutinated 34/75 aeromonas isolates from clinical and environmental sources. similar numbers of a. hydrophila, a. sobria and a. caviae isolates were agglutinated. the mabs were screened for their ability ...	1989	2483346
[intestinal infections caused by aeromonas].	we have identified 38 instances of intestinal infection by aeromonas and 4 by plesiomonas in 16,184 coprocultures carried out during a 4 year period in the hcu of zaragoza. the low prevalence can be related with the fact that specific media for the recovery of these organisms were not used. the species aeromonas sobria (47.36%) and a. caviae (39.47%) were more common than a. hydrophila (13.15%). aeromonas were isolated from patients with and without intestinal disease. the occurrence of gastroin ...	1989	2490673
antimicrobial susceptibility of sixty human fecal isolates of aeromonas species.	the mics of 21 antimicrobial agents were determined for 60 strains of aeromonas spp. isolated from human feces. all isolates tested were susceptible to aztreonam, tetracycline, imipenem, moxalactam, pipemidic acid, gentamicin, trimethoprim-sulfamethoxazole, pefloxacin and ciprofloxacin. resistance to erythromycin and streptomycin was observed in all 60 strains. aeromonas caviae was less susceptible to cefamandole, cefotaxime, norfloxacin, chloramphenicol, tetracycline, sulfamethoxazole and trime ...	1989	2496995
a randomized trial of anticoagulation with warfarin and of alternating chemotherapy in extensive small-cell lung cancer by the cancer and leukemia group b.	the cancer and leukemia group b (calgb) conducted a prospective randomized trial to evaluate the role of warfarin and alternating chemotherapy in extensive small-cell lung cancer (sccl). after stratification for sex and performance status, patients were randomly assigned to receive chemotherapy with methotrexate, doxorubicin (adriamycin; adria laboratories, columbus, oh), cyclophosphamide, and lomustine (ccnu) (macc), or macc plus warfarin (macc + w), or mitomycin, etoposide, cisplatin, and hexa ...	2008	2547030
effect of glucocorticoids and limiting nursing on the carbohydrate digestive capacity and growth rate of piglets.	the influence of glucocorticoid administration and limited nursing on piglet carbohydrase enzyme development and subsequent growth was examined in three experiments using 371 piglets. treatments in the first two experiments were formed by the factorial arrangement of hydrocortisone (-hyd or +hyd) and limited nursing (-ln or +ln) imposed form d 14 to weaning (d 28). hydrocortisone was replaced by adrenocorticotropic hormone (acth) in the third experiment. growth rates were severely depressed by h ...	1989	2556355
concept of the existence of human papillomavirus (hpv) dna in histologically normal squamous epithelium of the genital tract should be re-evaluated.	because of the crucial importance of guiding current thinking in the field of hpv epidemiology, the concept of the existence of hpv dna in histologically normal squamous epithelium was re-evaluated. a series of 102 randomly collected cervical punch biopsies, previously proved to contain the dna of hpv types 6, 11, 16, 18, 31 or 33 by in situ hybridization were subjected to analysis for the localization of hpv dna, i.e., whether found in the normal epithelium or at the lesion site only. this mate ...	1989	2561041
hydrogen peroxide mutagenicity towards salmonella typhimurium.	in bioassays conducted under controlled, comparable conditions, weak direct mutagenicity responses were observed for hydrogen peroxide in the standard (ames test) agar plate incorporation bioassay with salmonella typhimurium strains ta97, ta98, ta102, and ta1537, in a 20 min preincubation test with strains ta97, ta98, ta100, ta102, ta1537, and ta1538, and in a liquid incubation modification using strain ta1537. these results conclusively demonstrate that hydrogen peroxide is a weak mutagen, espe ...	1989	2572065
comparative sequence analysis, in vitro expression and biosynthesis of mouse prp.	a number of studies have indicated that an endogenous brain protein, prp, is associated with transmissible agents causing spongiform encephalopathies such as scrapie, kuru, and creutzfeldt-jakob disease. it has been proposed that prp derived from scrapie brain is the scrapie agent itself. to test directly whether the prp mrna in scrapie brain tissue can encode the scrapie agent, we expressed prp cdna cloned from scrapie-infected mouse brain in vitro. the expressed prp did not transmit scrapie to ...	1989	2574873
enrolled nurses. we're backing the charter!		2008	2587373
prp (proline-rich protein) genes linked to markers es-12 (esterase-12), ea-10 (erythrocyte alloantigen), and loci on distal mouse chromosome 6.	the closely linked proline-rich protein (prp) genes, coding for abundant salivary proteins, are located on distal mouse chromosome 6. they are part of a conserved linkage group that is represented on human chromosome 12p. two other markers, ea-10 and es-12, that were previously unassigned to a chromosome are closely linked to prp genes in the mouse.	1989	2613230
non-germ cell testicular tumours in nigerians.	non-germ cell testicular tumours are reported to be more common in peoples of negroid and asian descent than in caucasians. this group of tumours comprised seven of sixteen testicular tumours seen in a ten-year period at the university of benin teaching hospital, benin city, nigeria. however, unlike experiences elsewhere in africa and the west indies where paratesticular tumours accounted for a majority of these tumours, malignant lymphomas constituted over 70% of non-germinal testicular tumours ...	2008	2635452
non-germ cell testicular tumours in nigerians.	non-germ cell testicular tumours are reported to be more common in peoples of negroid and asian descent than in caucasians. this group of tumours comprised seven of sixteen testicular tumours seen in a ten-year period at the university of benin teaching hospital, benin city, nigeria. however, unlike experiences elsewhere in africa and the west indies where paratesticular tumours accounted for a majority of these tumours, malignant lymphomas constituted over 70% of non-germinal testicular tumours ...	2008	2635452
bacterial growth and toxin production in ileostomy effluents.	escherichia coli (2), vibrio cholerae (2) and aeromonas sobria (1) strains were examined for their ability to grow and produce toxins in samples of ileostomy fluid. three categories of response were observed: no detectable growth, growth without detectable toxin, and growth with detectable toxin. clear differences were apparent between samples of ileostomy fluid obtained from different individuals and between samples obtained from the same individual at different times. the patterns of response ...	1989	2649680
lead toxicity and iron deficiency in utah migrant children.	we determined the frequency of presumptive iron deficiency and lead toxicity in 198 utah migrant children, ages 9-72 months, during the summer of 1985. there were no confirmed cases of lead toxicity. thirteen per cent of those tested and 30 per cent of the children ages 9-23 months were iron deficient. hematocrit determinations accurately predicted iron deficiency in only 35 per cent of the children confirmed to have this disorder via erythrocyte protoporphyrin screening.	2009	2650572
[antibacterial and bactericidal activities of japanese green tea].	we found that extracts of japanese green tea leaves inhibited the growth of various bacteria causing diarrheal diseases. all tea samples tested showed antibacterial activity against staphylococcus aureus, s. epidermidis, vibrio cholerae o1, v. cholerae non o1. v. parahaemolyticus, v. mimicus, campylobacter jejuni and plesiomonas shigelloides. none of the tea samples had any effect on the growth of v. fluvialis, aeromonas sobria, a. hydrophila, pseudomonas aeruginosa, salmonella enteritidis, ente ...	1989	2677434
mutational specificity and the influence of excision repair: insights into the mechanisms of error-avoidance and error-fixation.	the excision repair process controlled by the uvrabc gene in escherichia coli is the major pathway for the repair of a diverse series of dna damages. to achieve a better understanding of the mechanics of this repair pathway and its impact upon mutagenesis, we have applied a recently developed technology by which the nature of mutation is determined at the dna sequence level. a comparison of the classes and distribution of mutation in excision-repair-proficient and excision-repair-deficient strai ...	1989	2698833
repeated hepatic ischemia as a treatment for carcinoid liver metastases.	hepatic ischemia has been used in the treatment of bilobar malignant carcinoid tumors in the liver. hepatic artery ligation, hepatic dearterialization, and embolization with nondegradable micromaterial have been followed by collateral formation and are associated with a high complication rate. to reduce this, an implantable vascular occluder permitting intermittent occlusion of the hepatic artery was used in 3 patients with bilateral malignant carcinoid in the liver, with high urinary excretion ...	2009	2741468
histamine concentration and ca2+ mobilization in arterial smooth muscle.	smooth muscle contraction is dependent on ca2+ entry from the extracellular space or release from intracellular stores. the sensitivity of these ca2+ sources to agonist concentration was evaluated by measuring myoplasmic [ca2+] (as estimated by aequorin), myosin phosphorylation, and isometric stress in the swine carotid media. high histamine concentrations produced transient elevations in [ca2+] and phosphorylation with rapid generation of near maximal stress. lower histamine concentrations prod ...	1989	2750885
fever response in laboratory-maintained and free-ranging chuckwallas (sauromalus obesus).	the fever response was studied in laboratory-maintained and free-ranging chuckwallas. five animals were used in a self-pairing laboratory experiment in which each animal was first injected with a sterile, pyrogen-free saline solution. approximately 7 days later, each individual was injected with a solution of 4.75 x 10(9) aeromonas sobria (formerly a. hydrophila). saline-injected individuals had a mean preferred body temperature (mpbt) of 36.8 +/- 0.4 (se) degrees c, whereas bacteria-injected an ...	1989	2750958
characterization of aeromonas sobria hemolysin by use of monoclonal antibodies against aeromonas hydrophila hemolysins.	aeromonas sobria produces hemolysin in a form activable with trypsin under defined cultural conditions. in immunoblotting analyses with the culture supernatant of a. sobria, the monoclonal antibody reacting specifically to aeromonas hydrophila ca-11 hemolysin bound to the 53,000- and 49,000-dalton bands before and after trypsinization, respectively. the monoclonal antibody reacting to a. hydrophila ah-1 hemolysin did not bind either band. a. sobria hemolysin is, therefore, related antigenically ...	1989	2768466
species identification of aeromonas strains based on carbon substrate oxidation profiles.	twenty clinical strains each of aeromonas hydrophila, aeromonas caviae, and aeromonas sobria were evaluated for their abilities to oxidize one or more of 95 carbon sources on a gn microplate (biolog, hayward, calif.). nine substrates yielded good, discriminatory values for the three species tested. the panel appears to be useful for the species identification of aeromonas isolates originating from human material.	1989	2778077
[experimental study of the role of male ixodid ticks in the circulation of the tick-borne encephalitis virus].	regular transmission of the tick-borne encephalitis virus by ixodidae males feeding on laboratory animals is demonstrated. the virus titres in the male saliva were 0.1-1.5 lgld50/0.03 ml. it was established that such doses didn't produce tense viremia in white mice or clinical tick-borne encephalitis.	1989	2779496
monoclonal antibodies as carriers of toxins.		2009	2785694
more on index of refraction.		2009	2805311
more on index of refraction.		2009	2805311
[the effect of progesterone, testosterone and estradiol on steroid hormone release by the ovarian follicles of cows in vitro].		1989	2806660
mechanism of the epsp synthase catalyzed reaction: evidence for the lack of a covalent carboxyvinyl intermediate in catalysis.	in order to detect covalent reaction intermediates in the 5-enolpyruvylshikimate-3-phosphate (epsp) synthase reaction, we have investigated the interaction of epsp synthase with the reaction product epsp. an exchange of epsp-methylene protons could be demonstrated by incubating epsps with epsp in d2o. since trace amounts of contaminating pi would lead to reversal of epsps reaction and hence methylene proton exchange, we added pyruvate kinase, adp, mg++ and k+. under these conditions, any contami ...	1988	2838023
biological and pathological consequences of feline infectious peritonitis virus infection in the cheetah.	an epizootic of feline infectious peritonitis in a captive cheetah population during 1982-1983 served to focus attention on the susceptibility of the cheetah (acinoyx jubatus) to infectious disease. subsequent observations based upon seroepidemiological surveys and electron microscopy of fecal material verified that cheetahs were indeed capable of being infected by coronaviruses, which were antigenically related to coronaviruses affecting domestic cats, i.e. feline infectious peritonitis virus/f ...	1988	2849387
post-translational processing of anglerfish islet somatostatin precursors.	two distinct somatostatin precursors are synthesized in anglerfish (af) islets. in addition to a precursor which has somatostatin 14 (ss-14) as a c-terminal cleavage product, a precursor which contains at its c-terminus [tyr7, gly10] ss-14 as a potential cleavage product is also synthesized. however, even though an arg-lys pair is located immediately n-terminal to ala1 of the c-terminal tetradecapeptide, [tyr7, gly10]ss-14 was not found in significant amounts in extracts of af islets. instead, a ...	2010	2863927
hypotensive effects after topical and intra-arterial administration of alpha-adrenergic agonists in isolated perfused rabbit eyes.	the influence of nonselective and selective alpha-adrenergic agonists on intraocular pressure (iop) was studied in isolated arterially perfused rabbit eyes. drugs were given intra-arterially or topically. with either route of administration, no initial hypertensive phase was observed after l-epinephrine, l-norepinephrine, l-phenylephrine (alpha 1), or methoxamine (alpha 1), but there was an immediate ocular hypotensive effect. the alpha 2-agonist b-ht 920 caused a nonsignificant 1 mm hg fall in ...	1985	2866480
changes in rat adrenal tyrosine hydroxylase mrna levels following chronic amphetamine administration.		1987	2888130
studies on 2(1h)-quinolinone derivatives as neuroleptic agents i. synthesis and biological activities of (4-phenyl-1-piperazinyl)-propoxy-2(1h)-quinolinone derivatives.		2010	2907733
identification and characterization of mg2+-dependent phosphotyrosyl protein phosphatase from rat liver cytosol.	although highly purified preparations of mg2+-dependent phosphoseryl protein phosphatase (also designated phosphatase ia or phosphatase 2c) dephosphorylated phosphotyrosyl histone, the activity has been resolved from phosphatase ia by polyacrylamide gel electrophoresis at ph 9.5. this novel phosphotyrosyl-specific protein phosphatase absolutely requires mg2+ or mn2+ for activity, is inhibited by zn2+, vanadate and fluoride, and has an optimal ph of 9.0 and mr = 50,000. certain properties of this ...	1986	3022716
[diarrhea caused by aeromonas in ivory coast].	the authors drawn epidemiological, clinical conclusions, and the geographical data concerning the diarrheas with aeromonas in ivory-coast. the results relate to a study realized from january 1982 to july 1985. out of the 1,594 excrements 627 germes have been isolated and among which 153 strains of aeromonas if for instance 24.4% of the whole germs. aeromonas caviae is the most frequent species (50%) compared to 27.3% for aeromonas sobria, and 22.7% for aeromonas hydrophila.	1986	3026671
roles of hormonal and nutritional factors in the regulation of rat liver alcohol dehydrogenase activity and ethanol elimination rate in vivo.	fasting reduced the liver alcohol dehydrogenase (adh) activity by 51% (p less than 0.001). insulin, within 2 hr, increased the adh activity found in fasted animals by 28% (p less than 0.02). insulin administration failed to stimulate the reduced adh activity in diabetic rats. however, adh activity in the diabetic-fed rats decreased by 52-54% (p less than 0.001) compared to normal-fed rats regardless of whether they were meal-fed or refed the normal chow. glucagon blocked by 15% (p less than 0.02 ...	1988	3044171
isolation of shiga toxin-resistant vero cells and their use for easy identification of the toxin.	shiga toxin-resistant vero cells were isolated by treatment of the cells with nitrosoguanidine. these mutant cells were not affected by shiga toxin at more than 1 microgram/ml, although the parent vero cells were sensitive to 25 pg of the toxin per ml. immunofluorescence studies showed that all the mutant cells had lost toxin-binding capacity. the cytotoxic activities of various bacterial cultures against the parent and mutant cells were compared. all samples from 10 strains of shigella dysenter ...	1988	3045003
fatal infection with aeromonas sobria and plesiomonas shigelloides.		1986	3081156
purification of cytotoxic enterotoxin of aeromonas sobria by use of monoclonal antibodies.	cytotoxic enterotoxin of aeromonas sobria was purified by affinity chromatography with monoclonal antibodies. the purified enterotoxin gave a single protein band in polyacrylamide gradient gel electrophoresis and its mol. wt estimated by this technique was 63,000; it had a pi of 6.2. the purified enterotoxin caused fluid accumulation in rat ileal loops and in infant mice, was cytotoxic to cultured cells, was haemolytic to human erythrocytes, and was lethal to mice after intravenous injection. th ...	1987	3104592
darkroom diseases and how to combat them.		2011	3112384
cerebral perfusion pressure: a hemodynamic mechanism of mannitol and the postmannitol hemogram.	sixteen patients each received infusions of 1 g of mannitol per kg over 5 to 10 minutes, and serial determinations of intracranial pressure (icp), systemic arterial blood pressure (sabp), central venous pressure, cerebral perfusion pressure (cpp), hematocrit, hemoglobin, serum na+, k+, osmolarity, and fluid balance were carried out for 4 hours. urine output was replaced volume for volume with 5% dextrose in 0.45% nacl solution. we tested the hypothesis that patients with high (greater than or eq ...	2010	3116451
bioaffinity sensors.		2011	3131631
bcr-abl oncogene renders myeloid cell line factor independent: potential autocrine mechanism in chronic myeloid leukemia.	in chronic myeloid leukemia (cml), a chromosome translocation has fused the bcr gene to the c-abl oncogene, such that a chimeric bcr-abl polypeptide can be made. to explore the biological properties of bcr-abl and compare them with those of the abelson virus (amulv) transforming gene (gag-v-abl), we have used either a synthetic bcr-v-abl gene that mimics the translocation product or, in some experiments, a bcr-c-abl cdna. a new retroviral vector was used to introduce the genes into the factor-de ...	2011	3147434
[lumbalgia among adolescents].		2011	3158780
[aquatic contamination of wounds by aeromonas sobria after bathing in the river].		1985	3160041
stimulation of rabbit synoviocyte prostaglandin e2 synthesis by lipopolysaccharides and their subunit structures.	lipopolysaccharides (lps) induce synoviocyte activation and may lead to destruction of synovial joint tissues. we assessed the production of prostaglandin e2 (pge2) as a measure of synoviocyte activation by lps and their subunit structures. diphosphoryl lipid a was the smallest portion of lipid a tested that stimulated pge2 production. the polysaccharide fraction of lps, containing the o antigen, was also active. intraarticular injections of the polysaccharide resulted in a synovitis very simila ...	1988	3162365
biochemical and toxigenic characteristics of aeromonas spp. isolated from diseased mammals, moribund and healthy fish.	in this study we describe biochemical, toxigenic and surface characteristics of 33 motile aeromonas isolated from diseased mammals, 3 from moribund marine mammals, 24 from healthy fish and 4 from moribund fish. aeromonas hydrophila, a. caviae and a. sobria were isolated from both mammals and fish but at a different incidence. aeromonas hydrophila was the predominant species isolated from clinical specimens; it was isolated from pneumonia, wound infections, septicemia and abortion in horses, catt ...	1988	3188376
enteropathogenicity of aeromonas species isolated from infants: a cohort study.	the significance of aeromonas spp. as potential enteric pathogens was evaluated in a cohort of 187 infants aged 3-18 months during a 16-week summer period. aeromonas spp. were isolated from 14 of the 196 (7.1%) diarrhoeal episodes detected and from eight (5.2%) of 153 samples from paired asymptomatic infants. carriage of bacterial enteropathogens excluding aeromonas spp. was detected in a high proportion (23%) of the asymptomatic children. almost all of the seven isolates of aeromonas sobria wer ...	1988	3216131
[toxic properties of lipopolysaccharide and lipid a of aeromonas sobria and non 01 vibrio cholerae].		1988	3216765