Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| effects of sex steroids on skin 5 alpha-reductase activity in vitro. | skin 5 alpha-reductase activity is the major factor influencing the manifestation of androgen excess. although oral contraceptives have been useful for the treatment of androgen excess, little is known of the independent effects of the various progestins and estrogens on inhibition of skin 5 alpha-reductase activity. we incubated minces of normal genital and pubic skin with physiologic concentrations of 3h-testosterone to assess 5 alpha-reductase activity by its conversion to 3h-dihydrotestoster ... | 2006 | 1828548 |
| [value of periorbital ecchymosis in the diagnosis of amyloidosis]. | 2007 | 1828572 | |
| [acute febrile polyarthritis disclosing horton's disease]. | 2006 | 1828585 | |
| [acute febrile polyarthritis disclosing horton's disease]. | 2006 | 1828585 | |
| oral administration of ssg, a beta-glucan obtained from sclerotinia sclerotiorum, affects the function of peyer's patch cells. | the effect of orally administered ssg, a beta-1,3-glucan obtained from the culture filtrate of a fungus, sclerotinia sclerotiorum ifo 9395, on the function of peyer's patch (pp) cells was investigated in comparison with that on spleen cells in mice. oral administration of ssg enhanced the proliferative response of pp cells to a t-cell mitogen, concanavalin a (con a), and a b-cell mitogen, lipopolysaccharide (lps), although the response of spleen cells was not affected. peyer's patch cells taken ... | 1991 | 1828793 |
| frequency of the tay-sachs disease splice and insertion mutations in the uk ashkenazi jewish population. | tay-sachs disease is a lethal neurodegenerative disorder caused by deficiency of the lysosomal enzyme beta-hexosaminidase a and inherited in an autosomal recessive fashion; carriers of the disease are 10 times more frequent in the ashkenazi jewish community than in the general population. over 90% of north american ashkenazi carriers tested have been shown to have either a splice site mutation at the boundary of exon 12 and intron 12 in the beta-hexosaminidase alpha subunit gene, or a 4 base pai ... | 2007 | 1828838 |
| the value of necropsy in oncology. | the effectiveness of diagnostic procedures in cancer patients was evaluated by comparing clinical with necropsy findings. necropsy and clinical records of 102 patients were reviewed for primary site and histology of tumour, metastatic sites, presence of second neoplasms, associated non-neoplastic diseases, terminal illness and cause of death. major discordances between clinical and postmortem findings were found in 34 (33%) cases: in 10 of these a correct clinical definition of site and histolog ... | 2006 | 1828961 |
| the value of necropsy in oncology. | the effectiveness of diagnostic procedures in cancer patients was evaluated by comparing clinical with necropsy findings. necropsy and clinical records of 102 patients were reviewed for primary site and histology of tumour, metastatic sites, presence of second neoplasms, associated non-neoplastic diseases, terminal illness and cause of death. major discordances between clinical and postmortem findings were found in 34 (33%) cases: in 10 of these a correct clinical definition of site and histolog ... | 2006 | 1828961 |
| factors predicting late mortality from breast cancer. | survival data of a cohort of 160 patients with breast cancer, who were still alive 10 years after the primary diagnosis, and who had been followed up for at least 22 years, were investigated to find out those factors that predict late mortality from breast cancer. the 13 factors investigated included age at diagnosis, histological type and grade, mitotic count, type of tumour margin, inflammatory cell reaction, extent of tumour necrosis, primary tumour size, axillary nodal status, dna ploidy and ... | 2007 | 1828967 |
| time course of changes in lipid peroxidation, pre- and postsynaptic cholinergic indices, nmda receptor binding and neuronal death in the gerbil hippocampus following transient ischemia. | brief (5 min) bilateral carotid occlusion in the gerbil produces forebrain ischemia resulting, as previously reported, in almost complete neuronal loss in the ca1 region of the hippocampus; this neuronal destruction occurs between the 4th and 7th day post-ischemia. various hippocampal biochemical indices were measured from just after such ischemia to 21 days of recirculation, and the temporal pattern of changes compared with that of cell loss. the level of thiobarbiturate reacting substances (tb ... | 2006 | 1829014 |
| time course of changes in lipid peroxidation, pre- and postsynaptic cholinergic indices, nmda receptor binding and neuronal death in the gerbil hippocampus following transient ischemia. | brief (5 min) bilateral carotid occlusion in the gerbil produces forebrain ischemia resulting, as previously reported, in almost complete neuronal loss in the ca1 region of the hippocampus; this neuronal destruction occurs between the 4th and 7th day post-ischemia. various hippocampal biochemical indices were measured from just after such ischemia to 21 days of recirculation, and the temporal pattern of changes compared with that of cell loss. the level of thiobarbiturate reacting substances (tb ... | 2006 | 1829014 |
| changes in the plasma levels of proteins c and s in young women on low-dose oestrogen oral contraceptives. | the physiological importance of proteins c and s as natural anticoagulants is demonstrated by the increased risk of thromboembolic disease among subjects with hereditary deficiency of both proteins. in the present study the effects were evaluated of low-dose oestrogen oral contraceptives (oc) on the plasma levels of immunological protein s, as free (ps-f), and in reversible complex with c4b-binding protein as well as functional protein c (pc) in a homogeneous group of 20 young healthy women. the ... | 2006 | 1829030 |
| changes in the plasma levels of proteins c and s in young women on low-dose oestrogen oral contraceptives. | the physiological importance of proteins c and s as natural anticoagulants is demonstrated by the increased risk of thromboembolic disease among subjects with hereditary deficiency of both proteins. in the present study the effects were evaluated of low-dose oestrogen oral contraceptives (oc) on the plasma levels of immunological protein s, as free (ps-f), and in reversible complex with c4b-binding protein as well as functional protein c (pc) in a homogeneous group of 20 young healthy women. the ... | 2006 | 1829030 |
| psychiatric disorders in the parents of autistic individuals. | eighty-one parents of 42 autistic probands and 34 parents of 18 down syndrome probands were examined using a semistructured, investigator-based version of the schedule for affective disorders and schizophrenia lifetime version to estimate the lifetime risk of psychiatric disorder. the lifetime prevalence rate of anxiety disorder was significantly greater in parents of autistic probands than in parents of down syndrome probands. the lifetime prevalence rate of major depressive disorder, while not ... | 2006 | 1829081 |
| psychiatric disorders in the parents of autistic individuals. | eighty-one parents of 42 autistic probands and 34 parents of 18 down syndrome probands were examined using a semistructured, investigator-based version of the schedule for affective disorders and schizophrenia lifetime version to estimate the lifetime risk of psychiatric disorder. the lifetime prevalence rate of anxiety disorder was significantly greater in parents of autistic probands than in parents of down syndrome probands. the lifetime prevalence rate of major depressive disorder, while not ... | 2006 | 1829081 |
| exposure to human immunodeficiency virus (hiv) type i indicated by hiv-specific t helper cell responses before detection of infection by polymerase chain reaction and serum antibodies [corrected]. | a healthy individual at risk for human immunodeficiency virus type 1 (hiv-1) infection was studied longitudinally for 19 months for evidence of exposure to and infection with hiv. peripheral blood mononuclear cells (pbmc) were tested at 1, 5, 13, 16, and 19 months for t helper (th) cell function by in vitro-generated proliferation and interleukin-2 production in response to four synthetic peptides corresponding to env of hiv. pbmc were also tested for proviral dna using gag primers by the polyme ... | 1991 | 1829105 |
| exposure to human immunodeficiency virus (hiv) type i indicated by hiv-specific t helper cell responses before detection of infection by polymerase chain reaction and serum antibodies [corrected]. | a healthy individual at risk for human immunodeficiency virus type 1 (hiv-1) infection was studied longitudinally for 19 months for evidence of exposure to and infection with hiv. peripheral blood mononuclear cells (pbmc) were tested at 1, 5, 13, 16, and 19 months for t helper (th) cell function by in vitro-generated proliferation and interleukin-2 production in response to four synthetic peptides corresponding to env of hiv. pbmc were also tested for proviral dna using gag primers by the polyme ... | 1991 | 1829105 |
| [acute rheumatoid arthritis with fever revealing horton's disease]. | 2007 | 1829184 | |
| [further study on the treatment of severe beta-thalassemia with myleran]. | in a previous paper we reported the results of treatment of five patients with beta-thalassemia major with myleran. three more cases are reported in this paper. after 40-50 days of oral administration of myleran, major hematological findings (hb, hbf, rbc) began to increase and remained at higher level for 4-5 months before dropping back to the original. the results of analysis of sister chromatid exchange (sce) showed no irreversible damage on chromosomal dna of the patients at the dosage used ... | 2007 | 1831710 |
| new perspective on cancer of the contralateral breast: a marker for assessing tamoxifen as a preventive agent. | 2007 | 1832192 | |
| [synthesis, secretion, and proteolytic degradation of diphtheria toxin in escherichia coli]. | the recombinant plasmids have been constructed encoding the synthesis of a full-sized diphtheria toxin from its own or pr, pl-promoters of bacteriophage lambda in escherichia coli cells. the high level constitutive synthesis of toxin results in slow cell growth and plasmid elimination. the toxin was mainly detected in the periplasm, partially in the membrane and to a less extent in the cytoplasm and culturing medium. the dimeric form of toxin was found in the cytoplasm. participation of toxin b- ... | 1991 | 1836836 |
| [fleas of the eastern kyzyl kum and their epizootic significance]. | the fauna of fleas in the east kisil-kum includes 24 species. different physicogeographic regions of sands are characterized by different spectra and number of species of fleas. the greatest share in collections is composed by xenopsylla gerbilli caspica--the parasite of rhombomys opimus. in autumn the other parasite of this rodent, coptopsylla lamellifer, is a mass species. all the most significant and long changes in the number of these species are associated with changes in the density of the ... | 1991 | 1839698 |
| the use of dacron plates for dot enzyme-linked immunosorbent assay (dot-elisa). | dacron (polyethylenetherephthalate) is proposed as a matrix for dot-elisa procedures, as an alternative to nitrocellulose. plates of dacron were partially hydrazinolyzed and hydrazide groups introduced were converted to azide groups. the derivative dacron-antigen was covalently linked on to the plates through these azide groups. the derivative dacron-antigen was exaustively washed according to crook and antigen was still fixed onto the plates. protein f1a purified from yersinia pestis was used a ... | 1991 | 1842438 |
| absence of na+,k(+)-atpase regulation of endosomal acidification in k562 erythroleukemia cells. analysis via inhibition of transferrin recycling by low temperatures. | transferrin (tf) acidification has been shown to be limited to ph 6 in murine balb/c 3t3 fibroblasts, human a549 epidermoid carcinoma cells, and chinese hamster ovary cells and is followed by alkalinization during recycling. in contrast, tf acidification in the human erythroleukemic cell line k562 proceeds to below ph 5.5, and alkalinization of internal tf during recycling is not observed. to explore the regulation of endosomal ph in k562 cells, we determined whether the existence of an early en ... | 1991 | 1847374 |
| atp-dependent partitioning of the dna template into supercoiled domains by escherichia coli uvrab. | the helicase action of the escherichia coli uvrab complex on a covalently closed circular dna template was monitored using bacterial dna topoisomerase i, which specifically removes negative supercoils. in the presence of e. coli dna topoisomerase i and atp, the uvrab complex gradually introduced positive supercoils into the input relaxed plasmid dna template. positive supercoils were not produced when e. coli dna topoisomerase i was replaced by eukaryotic dna topoisomerase i or when both e. coli ... | 1991 | 1847511 |
| structure and function of the maize spm transposable element. | the spm's primary transcript is alternatively spliced to give at least 4 different transcripts which code for proteins with extensive overlapping domains. two of these proteins, the tnpa and tnpd gene products, are necessary and sufficient to promote dspm transposition in tobacco. moreover, the tnpa gene product is also sufficient to suppress the basal level of expression observed in some dspm-disrupted genes, and probably to activate the expression of inactive elements and of other dspm-disrupt ... | 1991 | 1851643 |
| regulation of alcohol consumption by the renin-angiotensin system: a review of recent findings and a possible mechanism of action. | the renin-angiotensin system has traditionally been associated with the regulation of fluid and electrolyte balance. in this review we summarize the data which ascribes a completely new function to this system, i.e., the regulation of alcohol consumption. in addition, we suggest a possible mechanism for this effect based on the concept of a satiety or stop process. the approach taken was to examine the effect on alcohol intake of a wide variety of drug, genetic, dietary, surgical and neurosurgic ... | 2007 | 1852316 |
| [the prevention of nausea and vomiting induced by antineoplastic chemotherapy: the state of the art]. | 2007 | 1853098 | |
| [anti-endotoxin monoclonal antibodies in the treatment of gram-negative germ sepsis]. | 2007 | 1853112 | |
| [generalities on the immunological mechanisms of graft rejection]. | 2007 | 1853117 | |
| remembrances of the meadowbrook conferences--when steroids came to dna. | 2007 | 1855458 | |
| chronic carcinogenic and toxic effects of a single subcutaneous dose of cadmium in the male fischer rat. | the carcinogenic effects of cadmium have not been thoroughly assessed in the commonly used fischer (f344) rat. this study determined tumor incidence in various tissues of male f344/ncr rats after a single dose of cadmium. cadmium (as cdcl2) was given sc in the dorsal thoracic midline at 30 mumole/kg to 70 8-week old male f344 rats while controls (n = 50) received saline. rats were observed during the next 90 weeks. early deaths (less than or equal to 32 weeks), due mostly to acute cadmium-induce ... | 1991 | 1855489 |
| a patient instruction guide used in treating anug. | 2007 | 1855637 | |
| traumatic boutonnière deformity as a cause of acute hammer toe: a case report. | traumatic boutonnière deformity, well-described when occurring in the fingers, can occur in a lesser toe. the deformity mimics that of a hammer toe, but the onset is acute, and develops immediately after trauma. open repair of the central slip rupture and recentralization of the displaced lateral bands of the extensor mechanism with temporary pinning of the toe can give an excellent result. | 2006 | 1855710 |
| traumatic boutonnière deformity as a cause of acute hammer toe: a case report. | traumatic boutonnière deformity, well-described when occurring in the fingers, can occur in a lesser toe. the deformity mimics that of a hammer toe, but the onset is acute, and develops immediately after trauma. open repair of the central slip rupture and recentralization of the displaced lateral bands of the extensor mechanism with temporary pinning of the toe can give an excellent result. | 2006 | 1855710 |
| [prerequisites for therapy of inflammatory bowel diseases. pathophysiology--symptomatology--diagnosis]. | the etiology of the idiopathic chronic inflammatory bowel diseases crohn's disease and ulcerative colitis remains unclear. differences in prognosis, medical and surgical treatment, and the nature of expected complications require not only a differential diagnosis vis-a-vis other disorders, but also the correct diagnosis of these two diseases. symptomatology and clinical presentation can be mimicked both by infectious, ischemic and other chronic bowel diseases such as collagenous colitis, eosinop ... | 2006 | 1855748 |
| [prerequisites for therapy of inflammatory bowel diseases. pathophysiology--symptomatology--diagnosis]. | the etiology of the idiopathic chronic inflammatory bowel diseases crohn's disease and ulcerative colitis remains unclear. differences in prognosis, medical and surgical treatment, and the nature of expected complications require not only a differential diagnosis vis-a-vis other disorders, but also the correct diagnosis of these two diseases. symptomatology and clinical presentation can be mimicked both by infectious, ischemic and other chronic bowel diseases such as collagenous colitis, eosinop ... | 2006 | 1855748 |
| [meat as component of a balanced diet]. | from the point of view of the nutritionist, meat has an important role to play in supplying the body with proteins (essential amino acids, vitamins and minerals). there is no doubt that meat is the most valuable source of dietary iron. these facts make meat an important constituent of a balanced diet in a range of age and performance groups, including children and adolescents, pregnant women and nursing mothers, senior citizens and athletes. in the discussion about the nutritional/physiological ... | 2006 | 1855760 |
| [meat as component of a balanced diet]. | from the point of view of the nutritionist, meat has an important role to play in supplying the body with proteins (essential amino acids, vitamins and minerals). there is no doubt that meat is the most valuable source of dietary iron. these facts make meat an important constituent of a balanced diet in a range of age and performance groups, including children and adolescents, pregnant women and nursing mothers, senior citizens and athletes. in the discussion about the nutritional/physiological ... | 2006 | 1855760 |
| c1r subcomponent polymorphism in japanese: description of a new allele. | the polymorphism of c1r was investigated in 570 unrelated japanese individuals using isoelectric focusing and immunoblotting. a total of 11 different c1r phenotypes including a new pattern designated c1r 11-1 were observed. the allele frequencies were c1r*1 = 0.4561, c1r*2 = 0.3377, c1r*5 = 0.1956, c1r*8 = 0.0088 and c1r*r (c1r*9 and c1r*11) = 0.0018. the population data fitted the hardy-weinberg equilibrium. the c1r polymorphism in japanese was shown to be controlled by 3 common alleles, c1r*1, ... | 2007 | 1855783 |
| relevance of n-nitrosamines to oesophageal cancer in china. | oesophageal cancer occurs at a very high frequency in certain areas of china, especially in linxian county, henan province. previous studies suggested that n-nitroso compounds play a causative role. in order to study further the exposure of linxian inhabitants, the intake of n-nitrosamines in the diet was determined. the total daily intake of volatile nitrosamines and of n-nitroso-n-methylbenzylamine (nmbza) was higher in linxian than in two other counties. nmbza can induce cancer in animal and ... | 1991 | 1855832 |
| dietary sources of n-nitrosamines in a high-risk area for oesophageal cancer--kashmir, india. | samples of foods consumed frequently in kashmir, a high-risk area for oesophageal cancer, were analysed for the presence of volatile n-nitrosamines. relatively high levels of n-nitrosodimethylamine (ndma), n-nitrosopiperidine (npip) and n-nitrosopyrrolidine (npyr) were detected in smoked fish (20 micrograms/kg ndma), sun-dried spinach (5.8 micrograms/kg ndma; 23.8 micrograms/kg npip), sun-dried pumpkin (24.6 micrograms/kg npyr) and dried, mixed vegetables (10 micrograms/kg ndma). the possible ro ... | 2007 | 1855851 |
| nitrosamine activation and detoxication through free radicals and their derived cations. | the enzymatic activation of simple dialkylnitrosamines is widely perceived to involve cytochrome p450-mediated alpha-hydroxylation to generate an unstable alpha-hydroxynitrosamine. this process can also result in the denitrosation of the nitrosamine, presumably through a common intermediate. we present evidence that the critical intermediate is the alkynitrosaminomethyl free radical, which we generated by thermal decomposition of a nitrosamino acid perester. the radical rapidly loses no to gener ... | 2007 | 1855884 |
| participation of phenobarbital-inducible cytochrome p450 in the mutagenic activation of n-nitrosopropylamines by liver and lung 9000 g fractions from five animal species and man. | the mutagenicity of nine carcinogenic n-nitrosopropylamines was studied by the ames preincubation assay using 9000 g supernatant (s9) fractions or alcohol dehydrogenase. treatment of animals with polychlorinated biphenyls or phenobarbital resulted in a marked increase in the ability of liver s9 to activate n-nitrosobis(2-hydroxypropyl)amine, n-nitroso(2-hydroxypropyl)(2-oxopropyl)amine, n-nitrosobis(2-oxopropyl)amine, n-nitrosobis(2-acetoxypropyl)amine, n-nitroso-2,6-dimethylmorpholine, n-nitros ... | 1991 | 1855888 |
| nitrotyrosine as a new marker for endogenous nitrosation and nitration. | a sensitive and selective method has been developed for analysing 3-nitrotyrosine (nttyr), an exposure marker for exogenous and endogenous nitrosating or nitrating agents, in tissue and blood proteins by gas chromatography-thermal energy analysis. using this method, a number of kinetic studies were carried out. free and protein-bound tyrosine were reacted easily to yield nttyr. the method was also applied to the study of nttyr formation in vivo; a dose-dependent increase in nttyr was seen in bot ... | 1991 | 1855894 |
| analysis and pyrolysis of some n-nitrosamino acids in tobacco and tobacco smoke. | a new tobacco-specific nitrosamine, 4-(n-nitrosomethylamino)-4-(3-pyridyl)butyric acid (iso-nnac), has been identified in tobacco, and its structure was confirmed by gas chromatography-mass spectrometry following enrichment of a tobacco extract. the levels of iso-nnac ranged from 0.01 to 0.95 ppm. it does not induce dna repair in primary rat hepatocytes and is inactive as a tumorigenic agent in strain a mice. in order to study the fate of nitrosamino acids during smoking, we spiked cigarettes wi ... | 1991 | 1855899 |
| [the effect of yersinia pestis ev76 6 md plasmid on the composition of outer membrane proteins of yersinia pseudotuberculosis ypiii]. | on the basis of yersinia pseudotuberculosis strain ypiii the isogenic variants containing the different combinations of 47 md plasmids from yersinia pestis or yersinia pseudotuberculosis cells with the 6 md pyp plasmid from yersinia pestis ev (intact or having impaired the pla gene determining the synthesis of plasmocoagulase). the degradation of the secreted proteins encoded by the 47 md plasmids of yersinia pestis and yersinia pseudotuberculosis in the cells harbouring the 6md pyp plasmid has ... | 1991 | 1857369 |
| [the effect of a plague pathogen plasmid on lethality and immunogenicity]. | on the model of yersinia transconjugants (yersinia pestis, yersinia pseudotuberculosis, yersinia enterocolitica) carrying the conjugative cointegrates containing the 47 and 65 md plasmids from yersinia pestis the data were obtained on the different affects of the latter plasmids on the lethality and immunogenicity conferred by the host bacterial cells. the plasmid effects were drastically different during bacterial infection in mice or guinea pigs. the possibility of appearance of the recombinan ... | 1991 | 1857372 |
| [the effect of the bacterial genome on the expression and behavior of the plasmid determining the ca2+-dependence of the plague pathogen]. | the conjugative cointegrate containing the 47 md plasmid of yersinia pestis has been transferred into the strains of the different yersinia (yersinia pestis, yersinia pseudotuberculosis, yersinia enterocolitica) and escherichia coli ca. there appeared in the populations of recombinant yersinia under the conditions of ca2+ deficit at 37 degrees c the cells coming into the stasis stage or dying. it was shown on the model of yersinia enterocolitica that bacterial lethality might be prevented by exc ... | 1991 | 1857373 |
| the penis. | 2007 | 1863476 | |
| an open letter to emergency nurses from a survivor of a major head injury. | 2007 | 1865625 | |
| prenatal drug exposure: a growing problem for families. | 2007 | 1865787 | |
| altered lipid metabolism in parvovirus-infected cells. | a broad spectrum of cell lipid alterations are known to occur as a consequence of various viral infections. these changes include inhibition of lipid synthesis, stimulation of lipid synthesis and changes in the proportions of various lipids. the current study examined the effects of two parvoviruses on lipids of rat kidney (nrk) cells. cells were infected with h-1 or kilham rat virus (krv) and the effects on 14c-acetate incorporation determined. results showed that h-1 virus rapidly inhibited li ... | 1991 | 1865833 |
| cell migration and actin organization in cultured human primary, recurrent cutaneous and metastatic melanoma. time-lapse and image analysis. | random cell migration and actin organization in seven human primary, recurrent cutaneous, and metastatic melanoma cell lines were studied by time-lapse video recording and image analysis. the migration of over 800 randomly selected cells from the cell lines were recorded using an inverted microscope with an attached incubator housing. the fraction of cells with random migration rates greater than 10 microns/hour was 8% in an established primary melanoma cell line, 2% and 34% in two recurrent cut ... | 1991 | 1867326 |
| metabolic consequences of (regional) total pancreatectomy. | little information has been reported on the metabolic characteristics of the totally pancreatectomized patient or the efficacy of medical management after radical pancreatic surgery. the prospective evaluation of 49 such patients, with 31% followed for 48 or more months, forms the basis of this report. the major immediate postoperative challenge is control of diarrhea and weight stabilization. chronically patients have an increased daily caloric requirement (mean +/- se, 56 +/- 1 kcal/kg), not w ... | 2005 | 1867520 |
| expression of inducible angiosperm promoters in a gymnosperm, picea glauca (white spruce). | electrical discharge particle acceleration was used to test the transient expression of numerous inducible angiosperm promoters in a gymnosperm picea glauca (white spruce). promoter expression was assayed in three different tissues capable of in vitro regeneration, zygotic embryos, seedlings and embryogenic callus. the promoters tested include the light-inducible arabidopsis and soybean ribulose-1,5-bisphosphate small subunit promoters and a maize phosphoenolpyruvate carboxylase promoter; a soyb ... | 2003 | 1868222 |
| cardiogenic stroke in the elderly. | cardiogenic stroke accounts for 15-20% of all ischemic strokes and for more than double than number in the very elderly. in this article, available data regarding cardiogenic embolism, its prevention and management in the elderly are reviewed in addition to the epidemiology, diagnosis, and major sources of cardiac emboli, and nonrheumatic atrial fibrillation. | 2006 | 1868402 |
| metabolism of nicotine. | 2007 | 1868776 | |
| the risk factors of developing cataract in patients with uveitis. | 2007 | 1868955 | |
| [radioimmunological analysis in studying the persistence of the plague antigen in the body of rodents and ectoparasites in natural foci in siberia]. | to study the persistence of y. pestis capsular antigen, or fraction 1 (f1), in the body of less important plague carriers in the mountain altai and transbaikal natural foci, as well as in experimentally infected ticks, the liquid-phase competitive radioimmunoassay (ria) was used for the first time. in this study ria showed, due to its sensitivity, doubtless advantages over traditional methods, such as the passive hemagglutination (pha) test and the antibody neutralization (an) test, and made it ... | 1991 | 1872096 |
| atrial fibrillation during a subarachnoid block in a patient with undiagnosed mitral valve prolapse. | mitral valve prolapse (mvp) is a common cardiac abnormality, and there are numerous documented cases of intraoperative dysrhythmias. however, the authors describe what is believed to be the first case of atrial fibrillation in a patient with an undiagnosed mvp who was given a subarachnoid block. a possible clinical sequencing for the subarachnoid block is offered. the differential diagnosis, etiology, pathology, and pathophysiology of mvp are discussed. also detailed are the management of intrao ... | 2007 | 1874648 |
| distinction of mesothelioma from carcinoma in pleural effusions. an immunocytochemical study on routinely processed cytoblock preparations. | the study was designed to find out whether the commercially available antibodies bma 130 c, bma 120, v 9, kl 1, b 72.3 tag, hea 125 and ber-ep 4 would be of help in distinguishing carcinomas from a mesothelial process (mesothelioma/pleuritis) in pleural effusion specimens routinely processed by the cytoblock method. all of the 20 carcinomas included in the study but also 19 of the 20 mesotheliomas expressed cytokeratin (kl 1), whereas vimentin expression was found in 7 of the 20 carcinomas and 1 ... | 2007 | 1876528 |
| legal case briefs for nurses. or.: did nurse fail to call ambulance?; "hearsay evidence"; ga.: agency seeks injunction vs. former employee: "trade secret". | 2007 | 1876706 | |
| [the specificity of plague antigen fi in pha]. | it were inoculate a total of the 15 type and 13 group leptospira strains to the rattus flavipetus and rattus lose 137 rates in lei zhou peninsula. as the antisera acquired, it has been examined the lyso-agglutinative test in leptospira strains. up to standard serum it was to test for pha of plaque, employing the sensitized blood cell by fi from 4 antiplague institutes. all of tests are negative. in addition to test for 3 immune sera, hemorrhagic fever antisera (immunized animals apodemus agraius ... | 1991 | 1878960 |
| [cloning of the locus encoding synthesis of an outer membrane protein (omp2) of the calcium dependence plasmid of yersinia pestis (lehmann, neumann)]. | the genetic locus of yersinia pestis encoding synthesis of a 46-kda heat-inducible outer membrane protein (omp2) was cloned into pbr322 plasmid. the omp2 was shown to be analogous to previously described yoph and yop2b proteins. the fifth hindiii fragment of 48-mda calcium dependence plasmid pcad358 mediates production of 31- and 28-kda proteins, irrespective of orientation of the insertion. a 31-kda polypeptide seems to correspond to the yopj described elsewhere. the maps of bamhi and hindiii o ... | 1991 | 1879678 |
| [cyclic nucleotides, prostaglandins and thrombocyte aggregation in rats poisoned with "murine" yersinia pestis toxin]. | y. pestis "mouse" toxin, introduced intraperitoneally into rats in a dose of ld100 [correction of lg100], produces phasic changes in the thrombin-induced aggregation of thrombocytes and the content of prostaglandins and cyclic nucleotides in them. as the result of the damaging action on the endothelium of blood vessels at the initial period of intoxication, the concentration of prostaglandin 6-keto f1 alpha in blood plasma and camp [correction of camr] in thrombocytes sharply decreases, which ca ... | 1991 | 1882634 |
| acetylcholinesterase from schistosoma mansoni: immunological characterization. | the enzyme acetylcholinesterase (ache) is present in the trematode schistosoma mansoni, which infects humans and causes a severe disease called schistosomiasis or bilharzia. we have purified this enzyme and raised polyclonal antibodies against it. the specificity of these antibodies against the schistosome enzyme was demonstrated by their capacity to precipitate exclusively ache activity from cercariae extract and to recognize the 8s molecular form of the parasite's ache. on the other hand, they ... | 1991 | 1885212 |
| the protein sequence responsible for lipoprotein membrane localization in escherichia coli exhibits remarkable specificity. | structural information defining an n-terminal sequence required for the membrane sorting of bacterial lipoproteins has been previously garnered through the study of a hybrid outer membrane (om) lipo-beta-lactamase (ll) (ghrayeb and inouye (1984) j. biol. chem. 259, 463-467). introduction of an aspartate as the second residue of mature ll (d2 mutant) causes an inner membrane (im) localization of this protein (yamaguchi, k., yu, f., and inouye, m. (1988) cell 53, 423-432). introduction of as aspar ... | 1991 | 1885579 |
| note for guidance. production and quality control of cytokine products derived by biotechnological processes. committee for proprietary medicinal products: ad hoc working party on biotechnology/pharmacy and working party on safety medicines. | 2005 | 1888491 | |
| effects of environmental exposure on carbon polysulphone composites. | in vivo and in vitro studies were designed to characterize the material degradation associated with implantation of carbon fibre-reinforced polysulphone (c/ps). composite plates were compression moulded for both studies, and a fibre orientation of 0 degrees with the long axis and a fibre volume fraction of approximately 55% were used. the in vitro experiment involved soaking three groups of four plates each at 4, 12 and 26 wk in 0.9% saline solution at 37 degrees c. the plates were measured for ... | 1991 | 1888812 |
| factors promoting acute and chronic diseases caused by yersiniae. | the experimental system constructed with the medically significant yersiniae provides a powerful basic model for comparative study of factors required for expression of acute versus chronic disease. the system exploits the close genetic similarity between yersinia pestis, the etiological agent of bubonic plague, and enteropathogenic yersinia pseudotuberculosis and yersinia enterocolitica. y. pestis possesses three plasmids, of which one, shared by the enteropathogenic species, mediates a number ... | 1991 | 1889045 |
| does prestretching stainless-steel wire have any clinical significance? | clinical parameters of prestretch and tension forces placed on stainless-steel wire by 20 oral and maxillofacial surgeons were obtained. unstretched wire was clinically as tough or tougher than prestretched wire of a similar gauge. both prestretched and unstretched wires, twisted to their maximum, loosened when under tension. as the prestretch forces increased, the clinical strength of the wire diminished. | 2007 | 1890520 |
| visual cues and attention demand in locomotor positioning. | the aim of this study was to determine what visual cues are used to assess the time-to-contact (tc) with a stationary target during locomotor positioning. for this purpose, we performed an experiment with restricted central visual cues and analysed the attention demand involved in use of visual cues. 11 subjects were asked to walk towards a target surface and stop in front of it. two target sizes were used: the tau strategy, consisting of assessing tc from the relative expansion rate of the targ ... | 2007 | 1891329 |
| [active and inactive forms of cerebral cysticercosis. study of 10 cases]. | ten cases of neuro-cysticercosis attended in our hospital over the last five years are presented. six patients presented non-active parenchymatous calcifications of which four manifested epilepsy, one dementia caused by hydrocephalus and one other was asymptomatic. two patients presented active intraparenchymatous cysts with a clinic of epilepsy. one patient presenting cisternal -ventricular-parenchymal involvement and another with ependymal -meningeal-parenchymal involvement, both suffered of p ... | 2005 | 1891636 |
| cystic carcinoma of the prostate: findings on transrectal sonography. | 2007 | 1892036 | |
| adrenergic hypersensitivity after beta-blocker withdrawal in hypertrophic cardiomyopathy. | withdrawal of beta-blocker therapy has been associated with the development of adrenergic hypersensitivity and adverse clinical effects in patients with coronary artery disease and hypertension. the aim of this study was to establish the occurrence and clinical significance of adrenergic hypersensitivity after abrupt withdrawal of long-term beta blockade in hypertrophic cardiomyopathy. beta-adrenergic sensitivity was measured using the isoprenaline chronotropic dose25. symptom assessment chronot ... | 2007 | 1892084 |
| low-dose cyclosporine a in the treatment of disabling morphea. | 2003 | 1892419 | |
| the effects of probucol on lipoprotein metabolism in the rat. | the effects of probucol on liver and intestinal apolipoprotein, ldl-receptor and hepatic lipase gene expression, as well as plasma lipid and apolipoprotein levels and liver lipase activity were evaluated in male rats. administration of probucol decreased plasma triacylglycerols, without affecting plasma cholesterol. plasma apo e and apo b concentrations increased after probucol. since liver and intestinal apo b and apo e mrna levels remained unchanged, this increase could be attributed to a dela ... | 1991 | 1892873 |
| haemostatic changes in long-distance runners and their relevance to the prevention of ischaemic heart disease. | haemostatic changes may explain the paradoxical observations that regular exercise helps to prevent ischaemic heart disease but the risk of myocardial infarction and sudden death is actually increased during exercise. this study measured relevant haemostatic variables in 100 athletes before and after races of 10-26.2 miles duration and compared resting levels in athletes with 25 non-exercising controls. prothrombin time, kaolin cephalin clotting time, fibrinogen, factor vii, factor viii clotting ... | 2007 | 1893055 |
| cell populations and episodic periodontal attachment loss in humans. | the purpose of the present study was to assess possible associations between episodic probing attachment loss and cell populations in the supracrestal connective tissue in humans. 10 systemically healthy adult patients with untreated advanced periodontitis were monitored during a period of 10 months. at baseline and every month thereafter, probing attachment levels were measured at 6 sites of every tooth using an electronic pressure sensitive probe and flexible stents. corresponding contralatera ... | 2006 | 1894744 |
| marking width, calibration from tip and tine diameter of periodontal probes. | the present study comprises an investigation of 7 different probe types, representing currently-marketed major designs (who-cpitn, williams, michigan), as well as available calibration systems (engraved, etched and painted markings). width of markings, accuracy of calibration from probe tip, and tine diameter at the tip and at specified points along the tine were assessed, using a stereomicroscope at a magnification of x 40. blind duplicate measurements of these probe tine characteristics were 1 ... | 2006 | 1894745 |
| autotransplantation of third molars as treatment in advanced periodontal disease. | the aim of this study was to investigate the prognosis of replacing molars with advanced periodontitis by autotransplanted fully developed third molars. the patient sample consisted of 18 subjects, 24-58 years of age. the patients selected had at least 1 molar with advanced periodontal tissue destruction. after extraction of the diseased molar, autotransplantation of a third molar was immediately performed. after a splinting and healing period of 2-3 weeks, endodontic treatment was carried out. ... | 2006 | 1894746 |
| autotransplantation of third molars as treatment in advanced periodontal disease. | the aim of this study was to investigate the prognosis of replacing molars with advanced periodontitis by autotransplanted fully developed third molars. the patient sample consisted of 18 subjects, 24-58 years of age. the patients selected had at least 1 molar with advanced periodontal tissue destruction. after extraction of the diseased molar, autotransplantation of a third molar was immediately performed. after a splinting and healing period of 2-3 weeks, endodontic treatment was carried out. ... | 2006 | 1894746 |
| cytogenesis in the monkey retina. | time of cell origin in the retina of the rhesus monkey (macaca mulatta) was studied by plotting the number of heavily radiolabeled nuclei in autoradiograms prepared from 2- to 6-month-old animals, each of which was exposed to a pulse of 3h-thymidine (3h-tdr) on a single embryonic (e) or postnatal (p) day. cell birth in the monkey retina begins just after e27, and approximately 96% of cells are generated by e120. the remaining cells are produced during the last (approximately 45) prenatal days an ... | 1991 | 1894769 |
| pre-travel health care. | 2007 | 1895974 | |
| [the clinical efficacy of roxithromycin in patients with acute odontogenic infections]. | the clinical efficacy of a macrolide antibiotic, roxithromycin, was evaluated in 24 patients affected by acute odontogenic infections. patients were treated with a first dose of 300 mg p.o. which was followed by 150 mg p.o. 12-hourly for the following two days. total responses were evaluated by an arbitrary scale. the results showed that an excellent and good response was obtained in 99.96% of treated patients. on the basis of clinically compared data and the drug safety it may be concluded that ... | 2007 | 1896005 |
| identification and cloning of a fur regulatory gene in yersinia pestis. | yersinia pestis is one of many microorganisms responding to environmental iron concentrations by regulating the synthesis of proteins and an iron transport system(s). in a number of bacteria, expression of iron uptake systems and other virulence determinants is controlled by the fur regulatory protein. dna hybridization analysis revealed that both pigmented and nonpigmented cells of y. pestis possess a dna locus homologous to the escherichia coli fur gene. introduction of a fur-regulated beta-ga ... | 1991 | 1898928 |
| 5-enolpyruvylshikimate-3-phosphate synthase from escherichia coli--the substrate analogue bromopyruvate inactivates the enzyme by modifying cys-408 and lys-411. | in order to identify the essential reactive amino acid residues of 5-enolpyruvylshikimate-3-phosphate synthase, the reaction of the enzyme with its substrate analogue bromopyruvate was investigated. incubation of the enzyme with bromopyruvate resulted in a time-dependent loss of enzyme activity. the inactivation followed pseudo-first-order and saturation kinetics with a kinact of 28 microm and a maximum rate constant of 0.31 min-1. the inactivation was prevented by preincubation of the enzyme wi ... | 1991 | 1899181 |
| introduction of vascular smooth muscle cells expressing recombinant genes in vivo. | vascular smooth muscle cells contribute to the formation of atherosclerotic plaques by proliferating in response to vascular injury and releasing growth-promoting factors. because their autocrine and paracrine effects are not fully understood, expression of such growth factor genes in specific cell types in vivo would help to determine their mechanism of action. we describe a method to transfer vascular smooth muscle cells expressing recombinant gene products to localized segments of the arteria ... | 1991 | 1899366 |
| new serologic tests for early detection of coccidioidomycosis. | arizona college students suspected of having recently acquired coccidioidomycosis were tested for anticoccidioidal antibodies and circulating fungal antigens using conventional antibody detection methods and new elisa procedures. of 233 patients with compatible symptoms, 26 had anticoccidioidal antibodies detected by conventional tests. elisa detected antibodies in sera from 20 of these patients and also from another 25 patients. patients with antibodies detected by either conventional or elisa ... | 2007 | 1899877 |
| the yersinia pestis v antigen is a regulatory protein necessary for ca2(+)-dependent growth and maximal expression of low-ca2+ response virulence genes. | the low-ca2+ response is a multicomponent virulence regulon of the human-pathogenic yersiniae in which 12 known virulence genes are coordinately regulated in response to environmental cues of temperature, ca2+, and nucleotides such as atp. yersinial growth also is regulated, with full growth yield being permitted at 37 degrees c only if ca2+ or a nucleotide is present. in this study, we constructed and characterized a mutant yersinia pestis specifically defective in the gene encoding the v antig ... | 1991 | 1901573 |
| battle of the clotbusters. | 2007 | 1904288 | |
| tumor-targeted delivery of 8-hydroxyquinoline. | rif-1 mouse tumors express high levels of beta-glucuronidase activity relative to most normal tissues. the high activity can be exploited for targeting specific drugs preferentially to tumor tissues. in this study we examined the kinetics of 8-hydroxyquinoline (8-ohq) accumulation in tumor and in several normal tissues resulting from the in vivo deconjugation of 8-hydroxyquinolyl-glucuronide (8-ohq-glca). tumors were acidified with d-glucose and nahco3 prior to the administration of 8-ohq-glca; ... | 1991 | 1904410 |
| thyroid vascular conductance: differential effects of elevated plasma thyrotropin (tsh) induced by treatment with thioamides or tsh-releasing hormone. | we have reported previously that thyroid gland blood flow, expressed as vascular conductance (c) per mass, is decreased at very low and increased at very high chronic plasma tsh concentrations, but is apparently unchanged over a broad range of plasma tsh concentrations encompassing normal levels. the aim of the present study was to examine the apparently very steep dose-response relationship between elevated plasma tsh and thyroid vascular c/mass. in the first series of experiments, endogenous p ... | 1991 | 1905224 |
| [study of the dependence of gene expression of plague pathogen plasmid 65md on the host bacterium genome]. | the conjugative cointegrate containing yersinia pestis 65 md plasmid coding for the production of traction i antigen and mouse toxin has been transferred into yersinia pseudotuberculosis, yersinia enterocolitica and escherichia coli cells. analysis of the transconjugants obtained has confirmed the connection of the genetical determinants for the mentioned bacterial products with the 65 md plasmid. the similar level of fra and tox-genes expression has been found in yersinia cells while fraction i ... | 1991 | 1906986 |
| light chain composition of serum granulocyte binding immunoglobulins. | serum granulocyte binding igg, igm, and the light chain composition of granulocyte binding immunoglobulins were measured in 58 adult subjects, including 8 normal individuals, 6 with felty syndrome, 6 with chronic idiopathic neutropenia, 32 with b-cell chronic lymphocytic leukemia (cll), and 6 with multiple myeloma. an abnormal kappa/lambda ratio of granulocyte binding immunoglobulins was detected in 12 of 32 patients with cll. neutropenia in patients with cll did not correlate with an abnormal k ... | 2007 | 1907094 |
| incest can have devastating emotional and physical consequences, women physicians told. | 2007 | 1913420 | |
| access to information for adult adoptees. | 2007 | 1913424 | |
| the reciprocal relationship between practice and theory. | 2007 | 1913436 | |
| the significance of squamous differentiation in endometrial carcinoma. data from a gynecologic oncology group study. | squamous differentiation is identified in about 25% of endometrial adenocarcinomas (ac). its significance has been the subject of debate for decades, and it has been reported that the prognosis of adenoacanthoma (aa) is better than, the same as, and worse than that of ac. part of this confusion has resulted from semantic differences relating to the use of aa and adenosquamous carcinoma (as). to investigate the prognostic importance of squamous differentiation in endometrial carcinomas and compar ... | 2007 | 1913465 |