Publications

the itch is back.		1976	134986
histochemistry of oxidative enzymes in experimental allergic encephalomyelitis.	the histoenzymic pattern of oxidative enzymes (g3pd, idh, sd, g6pd,hbd, nadph: dehydrogenase) was investigated in experimental allergic encephalomyelitis (eae) produced in rats according to paterson [13]. the results obtained lead to following conclusions: (1) the neuroglia, including the white matter oligodendroglia of immunized rats, exhibits increased oxidoreductase activities; (2) the neuroallergic reaction induces some stimulation of the oxidoreductive metabolism of oligoden-droglia; (3) th ...	1976	186370
effects of adenine and cytokinins on growth and protein kinase activity of verticillium albo-atrum.	growth of verticillium albo-atrum in liquid czapek-dox broth was stimulated about four-fold by added 10 mm adenine, n6-benzyladenine, or kinetin. less stimulation was evident at lower concentrations. with none of these included in the basal growth medium, detectable protein kinase activity in cell-free extracts was low and responded minimally to camp (adenosine 3',5'-cyclic monophosphate) in the reaction mixture. with each of these compounds as an additive to the growth medium, protein kinase ac ...	1976	186711
[effect of 2,6-diaminopurine resistance mutations on adenine and adenosine assimilation by cells of an adenine-dependent strain of escherichia coli k-12].	in purine-requiring strain of escherichia coli k-12 defective in purine nucleoside phosphorylase (pur, pup) mutants (designated apt) have been obtained that are resistant to 2,6-diaminopurine on guanine-containing medium and incapable to utilize adenine for their growth at 42degreesc, but they are still sensitive to the analogue and can utilize adenine at 28degreesc. it has been shown that the introduction of the corresponding apt mutations in the genome of adenine-requiring strains impaired the ...	1976	187528
interrelationships between the central nervous system and patterns of adrenocorticotropic secretion following acute exposure to severe environmental conditions.		1976	187557
tape test as a simple new method for the study of compounds increasing the problem-solving ability of the rat.	a simple new method, the "tape test" has been developed for studying the enhancement of learning by drugs in "learning-dull" rats. a piece of adhesive tape is pressed on the left front pad of the rats. the time of tape removal by the animal, i.e., the problem-solving time is measured. in our experiments the selected learning-dull rats were used which were unable to remove the tape within 60 s observed on 3 consecutive days. the problem-solving ability of the rats was studied on 4 consecutive day ...	1976	135270
experimental evaluation of paracetamol antidotes.		1976	193746
[enzymomorphology of the vaccinal process in connection with formation of immunity to plague].	the studies conducted showed that the beginning of immunogenesis following the administration of live plague vaccine was preceded by a period of primary toxic action of multiplying microbes when the activity of a number of enzymes in the organs of guinea-pigs was temporarily reduced. subsequently, inductive and productive phases of formation of antibodies started against the background of normalization and growth of the enzymatic activity associated with mobilization of energy. the earliest hype ...	1976	194554
in vitro susceptibility and resistance of animal staphylococci to macrolide antibiotics and related compounds.	strains of staphylococcus aureus isolated from poultry, pigs and cases of bovine mastitis and strains of s. hyicus isolated from pigs were examined for their susceptibility of the macrolides and other related antibiotics. the susceptibility of these strains to erythromycin, oleandomycin, tylosin, spiramycin, lincomycin, clindamycin, virginiamycin, and its components virginiamycin s and m, was tested by the quantitative plate dilution method. with s. aureus, 3 p. 100 of the bovine, 12 p. 100 of t ...	1976	136223
energy-rich phosphates and transintestinal transport in rat intestine incubated in vitro at different temperatures.	in the present work, the transported fluid and the tissue content of atp, adp and amp has been evaluated in the jejunum rat intestine which was everted and incubated in vitro both at 28 degrees c and at 38 degrees c for 1 h. the energy-rich phosphates have been measured in the tissue at the beginning and at the end of the experiment as well as in vivo. these determinations have been made in the total intestine and in the scraped mucosa. atp and adp content are higher in vivo and lower but consta ...	1976	136993
effects of exercise training and exhaustion on 45ca uptake by rat skeletal muscle mitochondria and sarcoplasmic reticulum.	mitochondrial and sarcoplasmic reticular 45ca2+ uptake and ca2+-atpase activity were determined in skeletal muscle from exercise trained and non-trained rats at rest or following short-term exhaustive exercise. in trained rats exercised to exhaustion, mitochondrial 45ca2+ uptake was significantly depressed when compared to non-trained rats at rest. ca2+-atpase activity of sarcoplasmic reticulum from trained rats exercised to exhaustion was significantly increased as compared to trained rats at r ...	1976	134437
pituitary regulation of human growth hormone binding sites in rat liver membranes.	we have studied the binding of 125i-human growth hormone (hgh) to crude 100,000 x g membrane preparations from rat liver, and have studied factors which might regulate the capacity and affinity of hgh binding sites. membrane preparations have livers of pregnant rats bound between 8% and 18% of the 125i-hgh initially added, and 70%-80% of that bound was displaced by 1 mug of unlabeled hgh. humans prolactin (hprl) displaced 125 i-hgh in a manner parallel to hgh itself but with about one-third the ...	1976	175242
harmaline-induced tremor in the rat: abolition by 3-acetylpyridine destruction of cerebellar climbing fibers.		1976	134757
studies on specific properties of dog heart (na+-k+)-atpase.	three different methods used for partial purification of (na+-k+)-atpase, method a, matsui and schwartz (5), method b, fedelesová et al. (3), and method c, pitts et al. (6), were compared with respect to specific activities, yields, and recovery of the enzyme in preparations from the dog heart. highest specific activities of (na++k+)-atpase, as well as the ratio of (na+, +k+) + mg2+ to mg2+-atpase, and the second best recovery and yield have been found in the preparation obtained by method b. ho ...	1976	130659
[intensity of parasitic contacts in the colonies of large gerbils under conditions of different population density of the animals and their fleas].	in the period from april to may and september to october of 1967--1973 in the mujun-kum a radioactive tracing of great gerbils was carried out. in all 225 tests were conducted. the greatest intensity of parasitic contacts between the animals was noted at their average quantity. its further rise does not result in the increase of the parasitic relations. if the number of fleas is high the parasitic contacts level even at the relatively low number of great gerbils is usually high enough for a furt ...	1976	141021
suppressor mechanisms in neonatally acquired tolerance to a gross virus-induced lymphoma in rats.	tolerance to a highly immunogenic gross virus-induced tumour in wistar/furth rats (c58nt)d was produced by neonatal infection of the rats with the virus. these rats failed to reject the tumours when challenged 8 weeks after virus inoculation and to mount the appropriate cell-mediated immune response to the tumour. the mechanisms involved were studied in vivo by adoptive transfers into sub-lethally irradiated rats of tumour cells mixed with spleen cells and/or sera from normal, tolerant, or tumou ...	1976	135385
effect of testosterone administration on the epiphyseal cartilage of hypophysectomized rats.	for the study of the mechanism of action of testosterone histological, carbohydrate-, and enzyme histochemical investigations were carried out on the epiphyseal cartilage of (1) hypophysectomized rats treated with testosterone [(thx group); (2)] hypophysectomized rats without hormonal treatment (hx group), and (3) intact, untreated control rats. the results were compared with the data obtained in a previous experiment in which intact rats were treated with testosterone (t group). the experiments ...	1976	135467
comparison of heat shocking and acridine orange treatment in phage typing of nontypable strains of staphylococcus aureus.	forty-five percent of 108 nontypable strains of staphylococcus aureus from clinical and environmental sources were phage typable after heat shock and acridine orange treatment. although phage patterns were produced by different types of treatment, the same phage groups were present, showing specificity. the newly typable strains appear to be similar in phage group distribution to the primary typable strains typed at the peter bent brigham hospital during the same time period. ten of the original ...	1976	135770
studies of the histochemistry, ultrastructure, motor innervation, and regeneration of mammalian intrafusal muscle fibres.		1976	137430
[relationship between p. pestis and listeria under different environmental conditions].		1976	139540
crosslinking of membranes: the effect of dimethylsuberimidate, a bifunctional alkylating agent, on mitochondrial electron transport and atpase.		1976	130833
cleavage of thrombosthenin a by thrombin. evidence for the existence of two types of bovine platelet actin.	bovin platelet actin prepared by spudich's method (spudich, j. a. (1972) cold spring harbor symp. quant. biol. 27, 585-594) separated into two peaks on a sephadex g-200 column. the actin of both peaks had a mol. wt. of 42 000 on sodium dodecyl sulfate-polyacrylamide gel and activated myosin atpase, although in a quantitatively different manner. actin eluted in the first peak (probably an oligomeric form) was not polymerized in 2 mm mgcl2 and 0.05 m kcl, while that of the second peak went through ...	1976	130929
resistance to levomycetin and activity of several enzymes in escherichia coli and the agent of plague.	the authors compared the activity of acetyl-coa-synthetase and of the enzymes belonging to the group of asparaginic acid in levomycetin sensitive and resistant strains of y. pestis and e. coli. there were revealed marked differences in the activity of aspartase, fumarase, synthetase and desamidase of l-asparagin, and also of the enzyme activated by acetate in the e. coli strains with plasmide resistance. transmission of r-factor to the pestis was accompanied by decomposition of l-asparadein, for ...	1976	8940
[study of the role or weaning and of androgens in the determinism of adrenal sexual dimorphism at the moment of puberty in the guinea pig].	sexual dimorphism of the adrenal, which appears at puberty in guinea-pig, is not the fact of weaning. this dimorphism is suppressed by castration in male or injection of testosterone in female. testis androgens are the cause of the lower values of plasma and adrenal cortisol concentrations and of adrenal weight noticed in male compared with female between days 20 and 90 of postnatal life.	1976	134790
in vitro monitoring of cadaver kidney donor pretreatment by lymphocyte culture.	fourteen cadaver kidney donors were pretreated with a rapid infusion of 5 g of cyclophosphamide and 5 g of methylprednisolone in an attempt to reduce graft immunogenicity by altering immunogenic "passenger" leucocytes. the effects of this drug infusion on peripheral lymphocytes were monitored by measuring the ability of donor lymphocytes to respond and to stimulate recipient cells in mixed lymphocyte culture and by measuring their ability to respond to phytohaemagglutinin stimulation before and ...	1976	134860
a stabilised tris(hydroxymethyl)aminomethane adduct in reduced collagen.	the reduction of collagen with sodium [3h] borohydride in the presence of tris buffer results in the stabilization of a schiff base adduct which is formed between allysine residues and tris(hydroxymethyl)aminomethane. the reduced, radioactive derivative of this adduct has been identified in hydrolyzates or reduced collagen. it elutes before hydroxylysine on an amino acid analyzer column close to the position of dihydroxylysinonorleucine. similar artifacts may occur when aldehydes present in or a ...	1976	134871
a comparison between amantadine and bromocriptine using the stereotyped behaviour response test (sbr) in the rat.	amantadine (100 mg/kg), apomorphine (2.5-10 mg/kg) and bromocriptine (10-50 mg/kg) all produced stereotyped behaviour in the rat. apomorphine was rapid in onset and of short duration, amantadine was slower to reach a maximum and bromocriptine had a delayed onset of 50 min and a prolonged action. amantadine and bromocriptine were antagonised by pimozide (1 mg/kg for 30 min) suggesting an action on dopamine receptors, and by d,l-alpha-methyl-p-tyrosine (150 mg/kg for 3 h) suggesting an indirect ac ...	1976	134898
[bdellovibrio bacteriovorus as a factor in the self-purification of river water].		1976	134929
broader investigation into the external environment of the specific antigen of the infectious agent in epizootiological observation and study of the structure of natural foci of plague.	the possibilities of detection of the infectious agent in natural foci of plague can be expanded to some extent by using the method of search for the specific fi capsular antigen of the plague microbe in such objects of the external environment which have not yet been subjected to laboratory analysis and serological analysis in particular. such objects include soil from the burrow and the substrate of the nest of the rodent as well as the fleas of rodents and regurgitations of birds of prey. the ...	1976	135026
purification and characterization of a new ribopolynucleotide synthesizing enzyme from escherichia coli.		1976	135093
[experimental restoration of the renal artery. comparative study of 3 procedures (author's transl)].	presentation of theee procedures of experimental revascularization of the renal artery under microscopically controlled surgered (study of 19 dogs): --10 dacron velvet grafts, --6 hypogastric autografts, --3 spleno-renal autografts. results obtained by three means of investigation: selective angiography, measurement of renal flow using radioactive xenon, microscopic study of the anastomoses and the grafts: --10 dacron 10 failures, --6 hypogastric autografts, 4 successes 2 failures, --3 spleno-re ...	1976	135095
bulbourethral gland infections in mice associated with staphylococcus aureus.		1976	135128
liver plasma membrane enzyme activities following glutaraldehyde fixation.	the wachstein-meisel atpase histochemical method has been previously used to demonstrate the ultrastructural localization of this enzyme in both whole liver and isolated plasma membranes following fixation in glutaraldehyde. in the present study biochemical assay, of liver plasma membrane enzymes following fixation in cold 2.5% glutaraldehyde showed that approximately 40% of mg2+-atpase, but only 4% of (na+-k+)-atpase activity remained in membranes from either control or anit-treated rats. in ad ...	1976	135243
[tuberculosis in domestic animals and its relationship with human tuberculosis].		1976	135254
retrograde axonal transport of antibody to dopamine-beta-hydroxylase.		1976	56975
diagnosis of plaque: an analysis of the yersin-kitasato controversy.		1976	10879
[use of the phases of growth of the causative agents of plaque and pseudotuberculosis for differentiation of these microorganisms].		1976	56492
a serial study of pregnancy proteins in primigravidae.	the plasma concentrations from four 'pregnancy proteins' and three steroid hormones have been measured throughout pregnancy in 15 primigravidae. two of the proteins, human placental lactogen (hpl) and pregnancy-specific beta1-glycoprotein (psbetag), are specific for pregnancy and correlate well with the stage of gestation. it is suggested that measurement of psbetag may be useful in assessing feto-placental wellbeing. neither of the pregnancy-associated proteins, steriod-binding beta-globulin (s ...	1976	57799
transient inhibition of initiation of s-phase associated with dimethyl sulfoxide induction of murine erythroleukemia cells to erythroid differentiation.	the murine erythroleukemia cell (melc) line in suspension culture can be induced to differentiate to erythroid cells by various compounds, including dimethyl sulfoxide (me2so). analysis of the cell cycle, during differentiation induced by me2so, using thymidine incorporation, thymidine labeling index, and relative dna content per cell as measured by flow microfluorometry, demonstrates a transient inhibition of entry of cells into s-phase of the cell cycle which is detected as early as 5 hr and i ...	1977	64982
[use of the method of macrophage migration inhibition for titration of toxic activity in microbial fractions].		1977	75324
purification and properties of the methane mono-oxygenase enzyme system from methylosinus trichosporium ob3b.	1. a three-component enzyme system that catalyses the oxidation of methane to methanol has been highly purified from methylosinus trichosporium. 2. the components are (i) a soluble co-binding cytochrome c, (ii) a copper-containing protein and (iii) a small protein; the mol. wts. are 13 000, 47 000 and 9400 respectively. the cytochrome component cannot be replaced by similar cytochrome purified from pseudomonas extorquens or by horse heart cytochrome c. 3. the stoicheiometry suggests a mono-oxyge ...	1977	15544
prominent role of lysosomes in the proteolysis of rat liver mitochondria at neutral ph.		1977	15866
hormonal control of zinc uptake and binding in the rat dorsolateral prostate.	the zinc uptake in the dorsolateral prostate of rats was studied after different hormonal manipulations. orchiectomy reduced the uptake of 65zn. administration of estradiol benzoate to orchiectomized rats doubled the 65zn uptake, a phenomenon which was not observed in orchiectomized-adrenalectomized rats. adrenalectomy in orchiectomized rats had no effect on the concentration of radioactivity beyond the castration-induced decrease. a prolactin release inhibitor, 6-methyl-8-erogelenylacetamide, r ...	1977	15955
ammonia toxicity in cattle. ii. changes in carotid and jugular blood components associated with toxicity.		1977	15959
the transport of l-leucine into the brain of the rat in vivo: saturable and non-saturable components of influx.		1977	16270
vibrio background in the city of frunze.		1977	17976
value of sputum culture in diagnosis of pneumococcal pneumonia.	in our laboratory, culture of sputum was extremely useful in diagnosing the etiology of pneumococcal pneumonia. of 31 consecutive patients with bacteremic pneumococcal pneumonia, 29 (94%) had streptococcus pneumoniae cultured from sputum. recovery of pneumococci in culture was enhanced by anaerobic incubation as well as by a plate bile test and an optochin disk on a primary blood agar plate.	1977	18489
immunization with dextransucrases, levansucrases, and glycosidic hydrolases from oral streptococci. ii. immunization with glucosyltransferases, fructosyltransferases, and glycosidic hydrolases from oral streptococci in monkeys.	the feasibility of immunizing monkeys with enzymes from oral streptococci in an attempt to reduce dental caries was investigated. forty rhesus monkeys, macaca mulatta, were used. cariogenic streptococci, s mutans, were implanted into all the monkeys' mouths. there was no pathological effect resulting from immunization. of the 40 animals, 30 retained the implanted flora throughout the experiment; the remaining 10 were reimplanted until the streptococci remained. in six months, gross carious lesio ...	1977	98540
an investigation of heavy meromyosin-adp binding equilibria by proton release measurements.	the interaction of magnesium-adp with skeletal muscle heavy meromyosin has been studied by measuring the accompanying release of protons. total ph changes of the order of 0.03 were involved, and measurements were performed with a discrimination of some ten-thousandths of a ph unit. at ph 8.0 and 25 degrees c about 0.5 mol of protons per mol of heavy meromyosin is released at saturation. a stoichiometry of binding close to 2 mol of adp per mol of protein was found, with a binding constant, obtain ...	1977	15588
participation of gaba receptors in the short-term activation of striatal tyrosine-3-monooxygenase elicited by neuroleptics.		1977	18893
recovery of preimplantation blastocysts in the squirrel monkey by a laparoscopic technique.	a laparoscopic uterine flushing technique has been developed for the recovery of preimplantation embryos from the squirrel monkey. fourteen adult female squirrel monkeys were induced to ovulate with 4 or 5 days' treatment with follicle-stimulating hormone (1 mg) followed by human chorionic gonadotropin (hcg) (500 iu). natural mating with a fertile male or artificial insemination was performed near the time of ovulation. thirty-six hours and eleven days after hcg administration, the females were ...	1977	140077
preparation of human immunoglobulin free of plasmin and anticomplement activities.	human igg separated by cohn fractionation showed variability in the content of aggregates, plasminogen and anticomplement activity. the plasminogen was removed or markedly reduced by affinity chromatography on sepharose-lysine. anticomplement activity was reduced by chromatography of cohn fraction ii on deae-cellulose. preparations of igg obtained by chromatography of intermediates from cohn fractionation (e.g. cohn fii + fiii or fii + fiii w) on deae-cellulose were devoid of aggregates, plasmin ...	1977	140530
fluorescence of human liver alanine aminopeptidase.	fluorescence of human liver alanine aminopeptidase has been attributed to tryptophan fluorescence. the fluorescence maximum is at 330 nm, 20 nm lower than that for free tryptophan, suggesting that most of the enzyme tryptophans are in a nonpolar environment and are shielded from solvent. quenching of enzyme fluorescence by iodide, pyridine, and n-methyl nicotinamide also demonstrates that enzyme tryptophan residues are largely buried and inaccessible to solvent. those accessible are in negativel ...	1977	143669
[role of onium groups in the interaction of asymmetric bis-cationic cholinomimetics with n-cholinoreceptors].		1977	145360
mitogenic response of mouse spleen cells and gelation of limulus lysate by lipopolysaccharide of yersinia pestis and evidence for neutralization of lipopolysaccharide by polymyxin b.	lipopolysaccharide (lps) extracted with phenol and water from yersinia pestis was compared with lps of escherichia coli for stimulation of deoxyribonucleic acid synthesis in mouse spleen cells (lymphocyte mitogenesis), gelation of limulus lysate, pyrogenicity in the rabbit, and susceptibility to inhibition of these activities by polymyxin b sulfate (pbs). lps of y. pestis stimulated deoxyribonucleic acid synthesis in mouse spleen cell cultures over the same quantitative range as lps of e. coli. ...	1977	200563
[migration of transformed fibroblast-like cells on substrates with patterned relief-work (quantitative study)].	the quantitative estimation of migration ability of transformed fibroblast-like cells of various epecies (mouse , rat, hamster, man) cultured on the substratum with grooves of various depth (5--40 mcm) was performed. of the majority of 11 cell lines examined, a reduced migration capacity up to its total disappeanance was registered as compared with the homological normal embryonic cells. a more pronounced reduction of migration ability was shown in mouse and rat transformed cells and less in hu ...	1977	201058
cell culture propagation of porcine rotavirus (reovirus-like agent).	two isolates of porcine rotavirus (reovirus-like agent) were isolated and passaged in primary procine kidney cell cultures. viral infectivity for cells was monitored by immunofluorescence because viral cytopathic effect was moderate. successful passage of virus in cell culture required that viral suspensions obtained from infected cell cultures be treated with pancreatin prior to inoculation onto cell monolayers. porcine rotavirus passage in cell culture also was accomplished, using trypsin trea ...	1977	201198
polypeptides and antigens of herpes simplex virus; their nature and relevance in chemotherapy and epidemiology of herpes infections.		1977	193819
the storage lipids in tangier disease. a physical chemical study.	the physical states and phase behavior of the lipids of the spleen, liver, and splenic artery from a 38-yr-old man with tangier disease were studied. many intracellular lipid droplets in the smectic liquid crystalline state were identified by polarizing microscopy in macrophages in both the spleen and liver, but not in the splenic artery. the droplets within individual cells melted sharply over a narrow temperature range, indicating a uniform lipid composition of the droplets of each cell. howev ...	1977	193870
altered lethality of murine toxin from yersinia pestis under various metabolic conditions.		1977	190614
[ring of the chromosome 4. ii. without facial dysmorphism].	a r(4) was observed in a 5-year-old female patient, with growth retardation, a near normal psychomotor development and with no major dysmorphism. the break points were in p16 and q33. after comparison with other known observations of r(4) it is suggested that the phenotype of monosomy 4p is due to monosomy for the distal band 4p16.	1977	302682
partial tetrasomy 9(9pter to 9q2101) due to an extra iso-dicentric chromosome.	a 3-year-old boy with partial no. 9 tetrasomy is described. the patient showed markedly retarded physical and mental development as well as multiple congenital anomalies. routine chromosome analysis revealed an extra c-group chromosome. it had a pronounced secondary constriction at the proximal part of its long arm. based on studies by a variety of banding techniques, the extra chromosome was identified to be an iso-dicentric no. 9 chromosome with inactivation of one of the two centromeres, the ...	1977	302683
mosaic 45,xy,-21/46,xy in a child with g deletion syndrome i.	a mosaic 45,xy,-21/46,xy was found in a boy with g deletion syndrome i who showed microcephaly, downward, antimongoloid slanted eyes, micrognathism, large, low set ears, small penis and bilateral inguinoscrotal hernia.	1977	302684
erythrocyte autoantibodies induced in mice immunized with rat antigens.	antibody reacting against syngeneic mouse erythrocytes could not be elicited (by rat erythrocytes) in athymic nude mice. rat antigen preparations from heart, muscle testes, brain erythrocyte ghosts and foetal material failed to elicit detectable autoantibody reactivity against mouse erythrocytes, even though all these preparations (other than brain and foetal) induced a reduction in half life of syngeneic murine erythrocytes in vivo. we suggest that an unstable rat erythrocyte antigen is respons ...	1977	303095
induction in b2/b2 chickens of immunity to transplantable carcinogen-induced fibrosarcomas mediated by t-cell monocyte cooperation: role of delayed hypersensitivity to unrelated antigens.		1977	303451
[pharmacologic properties of ortho-ethoxy-benzamide].		1977	305744
partial duplication 5q syndrome: phenotypic similarity in two sisters with identical karyotype (partial duplication 5q33 leads to 5qter and partial deficiency 8p23 leads to pter).	two sisters with statomotor developmental retardation microcephaly, hydrocephalus internus and externus without signs of pressure, heart defect (ventricular septal defect), early pulmonary resistance and characteristic facial changes were found to have the same unbalanced karyotype with partial trisomy 5q3300 leads to 5qter and partial monosomy 8p2300 leads to 8pter, derived from a balanced reciprocal paternal translocation: 46,xy,t(5;8)(q3300;p2300). the older girl was tested for the erythrocyt ...	1977	305758
cellular immune response to yersinia pestis modulated by product(s) from thymus-derived lymphocytes.	resistance to infection with yersinia pestis was found to depend on whether the macrophage can inactivate and withstand the cytotoxic effects of phagocytized y. pestis. serum from mice immunized with antigens of y. pestis enhanced the resistance of monolayers of normal cultures to the cytotoxic effects of y. pestis and increased the capacity of peritoneal exudate cells from immune mice to inactivate these bacteria. the enhancing component of the serum was not removed by absorption with heat-kill ...	1977	299867
effect of rhythmic alternation of protein depletion and repletion on serum protein synthesis.	the authors attempted to determine whether repeated protein depletion would produce changes in the organism's response to this unfavourable situation indicative of the preservation of information on past depletion and of its inclusion in the formation of the organism's defences against repetition of this unphysiological state. it can be concluded from the results that the anticipated trend was demonstrated. the question of the site of origin, storage and action of this information was not resolv ...	1977	140403
inhibition of (na+ + k+)-stimulated atpase of heart by fatty acids.		1977	140941
[spheroplasts of plague microbe strains from the transcaucasian uplands and their capacity for pesticin synthesis].	spherical formations of the plague microbe strains from the transcaucasian upland, i plague microbe strain of the sandwort variety and i strain of the marmot variety were obtained under the effect of lithium chloride. they had the remains of the cell wall, were viable, sensitive to osmotic shock, preserved sensitivity to the specific bacteriophage and pesticins. all this was evident of isolation of the spheroplasts of the plague microbe. the spheroplasts showed a capacity for pesticin production ...	1977	142442
plague in small mammals and humans in rangoon, burma.		1977	146917
conservation of transfer ribonucleic acid and 5s ribonucleic acid cistrons in enterobacteriaceae.	the genes for tranfer ribonucleic acid (tdna) and 5s ribonucleic acid (5sdna) were isolated from the total deoxyribonucleic acid (dna) of escherichia coli. the relatedness of tdna and 5s from e. coli and other species of enterobacteriaceae was determined by reassociation of the isolated genes labeled with 32po4 to unlabeled, unfractionated dna. double-stranded dna was separated from unreacted dna by hydroxyapatite chromatography. thermal elution profiles were done to determine the amount of unpa ...	1977	321428
a simple one-step hemolytic assay for c2 with c2-deficient human serum.	a simple one-step procedure has been developed for the molecular titration of c2 by utilizing the ability of the test material to restore the hemolytic activity of human serum selectively deficient in c2 (c2d serum). in this assay, equal volumes of ea (10(8) cells/ml), c2d serum (1/20), and a suitable dilution of a source of c2 were incubated at 37 degrees c for 60 min and the fraction of cells lysed was used to calculate the effective molecules of c2/ml test material. the assay can be used to t ...	1977	321681
repression of inducible enzyme synthesis in a mutant of escherichia coli k 12 deleted for the ptsh gene.	the genome of lambda phage with thermosensitive repressor was inserted into the pts region of the escherichia coli chromosome. this lysogenic culture possessed the pts1 phenotype at 30 degrees c. a mutant strain with a deletion covering the ptsh gene was isolated after a prophage curing procedure. the deletion nature of the pts mutation was confirmed in genetical and biochemical experiments. the deletion covered a small fragment of the bacterial genome not extending in the ptsi and lig genes. th ...	1977	329116
[neuramininase activity of the representatives of the genus yersinia].	the authors demonstrated the presence of neuraminidase in past. pestis. optimal conditions for its formation and detection were chosen. extracellular form of neuraminidase was revealed. an increase of cultivation temperature led to the elevation of the neuraminidase activity in past. pestis cells. neuraminidase was revealed in bacteria affiliated to past. pestis (causative agents of pseudotuberculosis and y. enterocolitica).	1977	331768
[ultrastructural changes in plague microbes, strain ev, and splenic cells of guinea pigs in their interaction in vitro].	dilatation of the endoplasmic reticulum cavities, an increase in the number of ribosomes near bacteria, deformation of mitochondria and coarsening of cristae were revealed in phagocytosis of past. pestis, strain ev, by reticular cells in the tissue culture of the spleen of intact guinea pigs. lipophanerous "reticular" inclusions were found in the differentiated reticular cells of the infected cultures. in the reticular cell cytoplasma besides the intact bacteria there were revealed past. pestis ...	1977	331769
[spheroplast bacteriocin from strains of the causative agent of pseudotuberculosis and its identification by the antibacterial activity spectrum and the morphology of the inhibition zones].	capacity for production of bactericin was found in the spheroplasts of the strains of the rodent pseudotuberculosis microbe. the author named it as pseudotuberculocin. the bacteriocin production was not detected in the initial strains of the pseudotuberculosis microbe. pseudotuberculocin differed in the antibacterial spectrum and morphology of the growth inhibition zones formed on the plates with the indicator strains from the pesticins produced by the strains of the plaque microbe of the marmot ...	1977	334050
[origin of plague moderate phages of serotype 2].	results of study of the negative colonies morphology, the structure of corpuscles, antigenic properties, specificity, and the action range permitted to refer the phages obtained from 18 e. coli strain, 1 plaque strain, and 1 pseudotoberculosis bacillus strain to the same group and to identify them with plague phages of serological type 2. isolation of the same phage type from different bacterial species permits to regard them as "polyhostal" ones. e. coli should be considered as the main carrier ...	1977	335729
[new methods of laboratory diagnosis of plaque and cholera].		1977	339614
beta-adrenergic blocking activity of yersinia pestis murine toxin.	yersinia pestis plague murine toxin has been found to inhibit the mobilization of free fatty acids in mice in a manner similar to that of beta-adrenergic blocking agents. the blockage is detectable 75 min after injection of the toxin (1 to 2 mean lethal doses). the degree of inhibition was directly correlated with the toxicity of a given toxin preparation. agents such as cholera toxin or glucagon, with apparently distinct receptors from beta-adrenergic receptors, stimulated adenylate cyclase and ...	1977	198377
decline of maternal antibodies to plague in norway rats.	the decline of maternal antibodies to the fraciton i antigen of yersinia pestis was investigated in newly weaned rattus norvegicus obtained from dams vaccinated with strain ev76(51f) of y. pestis. iha titre decreased by 50% each 7-3 days and cf titre declined 50% each 10-0 days in young rats. an analysis of available data indicated that maternal iha and cf antibodies could persist to 3 months of age. therefore, positive serologic reactions in young r. norvegicus, detected in the course of serolo ...	1977	264498
[biochemical characteristics of yersinia pestis samples isolated in brazil].		1977	283471
primary culture of adult rat liver cells. i. preparation of isolated cells from trypsin-perfused liver of adult rat.	isolated hepatic cells from adult rats were prepared by perfusing the livers with trypsin. the highest yield of viable cells was obtained by perfusing the liver with 0.1% trypsin, ph 7.0, at 37 degrees c for 30 min. following this treatment about 70% of cells excluded trypan blue. the isolated cells contained many binucleate cells. between 60 and 70% of dna present originally in the liver was recovered from the isolated hepatic cells, which had higher glucose 6-phosphatase activity than the live ...	1977	205092
[toxicity of bacterial polysaccharides (a review of the literature)].		1977	402887
the role of cellular locomotion in leukemic infiltration. an organ culture study on penetration of l 5222 rat leukemia cells into the chick embryo mesonephros.	the significance of cellular locomotion for leukemic infiltration was investigated using l 5222 rat leukemia cells. previous cinemicrographic studies have shown that these cells are able to locomote only after formation of a uropod-like posterior extension. this characteristic locomotive configuration of l 5222 cells is easily recognizable in scanning electron micrographs and appropriate sections. leukemia cells were inoculated on slices of chick embryo mesonephros incubated for 24h; at this tim ...	1977	403674
amino acid degrading enzymes for cancer therapy.	the development of microbial enzymes for cancer therapy presents difficulties not commonly experienced with biological drugs. the development of the enzyme asparaginase from escherichia coli in the usa and of the serologically different asparaginase from the plant pathogen erwinia carotovora in this establishment, has not only added to the choice of antileukaemia drugs but also provided a valuable guide to the selection and development of new therapeutic enzymes. our own programme has led to the ...	1977	415922
another focus of sylvatic plague in kenya.		1977	612432
cyclic kinetics and mathematical expression of the primary immune response to soluble antigen. vii. the conveyer hypothesis and its mathematical expression.	the conveyer hypothesis is based on the fact that because of clone predetermination, antibody production takes place in an organism without the presence of antigen as a result of natural cell differentiation. soluble antigen is an analogue of a specific mitogen which gives rise to reproduction mainly of cells carrying on their surface the immunoglobulin receptors to the given antigen. the mathematical model of the conveyer hypothesis takes into account the initial conditions, among them the back ...	1977	557428
[sensitivity of repair-defective mutants of the plague microbe to the action of physical and chemical agents].	by the character of the sensitivity of uv-irradiation, to n-methyl-n'-nitro-n-nitrosoguanidine, 5-bromuracil, mitomycin c, crystalviolet, and by the capacity to restore phage injuries the 1435-a and 1435-24 mutants were referred to the uvr-hcr-, 17 mutant--to the uvr-hcr+, and 35 mutant--to lon genotype. as a result of uv irradiation the experimental strains formed heteromorphic forms of bacteria, spindle-shaped, filamentous cells, were sensitive to the action of static electrical field of high ...	1977	899436
volume and shape of normal human spermatozoa.	an improved apparatus for measuring the electrical size of particles, developed in this laboratory and based on the principle of the coulter counter, is used to size human spermatozoa. the typical size distribution is unimodel, with a skew to the right. the actual quantity determined by the measuring system is electrical size (i.e., shape factor x volume); in order to extract the volume, it is necessary to obtain an independence measure of particle shape. this is done by estimating the relative ...	1977	321264
the serological response to yersinia pestis infection.	passive haemagglutination antibody titres to fraction i antigen of yersinia pestis were plotted against day of clinical illness in 82 patients in viet nam. a rise was evident by day 5 with a peak at day 14, after which a plateau occurred. in contrast to all other patients, 2 patients with recurrent infections had elevated titres at the time of admission which decreased significantly during convalescence.	1977	302154
cell-mediated immunity in experimental nocardia asteroides infection.	experimental mycetoma-like lesions developed in guinea pigs after subcutaneous injection of nocardia asteroides. although delayed hypersensitivity appeared earlier, increased macrophage migration inhibition and microbicidal activity appeared after 7 weeks. when the lesions healed, high cell-mediated immunity was present. cell-mediated immunity was transferred to normal recipient guinea pigs from healed donor guinea pigs by spleen cell transfer. recipient guinea pigs showed marked protection agai ...	1977	321348
[occurrence of induced vitamin-dependent mutants of yersinia pestis].	vitamin-dependent mutants were isolated from yersinia pestis after the treatment with supermutagens. from 13 mutants obtained 10 appeared to be unstable. the stable vitamin-dependent mutants were revealed with the frequency of 2.5.10(-11) divided by 4.9.10(-11) by the indirect method of selection and 5.10(-7) by the use of davis's method. the frequency of amino acid and nitrogen base dependent auxotroph isolation was significantly higher than that of the vitamin-dependent mutants.	1977	614956
immunity in plague: protection of the vervet (cercopithecus aethips) against pneumonic plague by the oral administration of live attenuated yersinia pestis.	protection against pneumonic plague by the oral administration of a live, attenuated yersinia pestis vaccine, ev76 (paris) f, was evaluated in the vervet (cercopithecus aethips). six animals were vaccinated with a dose of 1.175 x 10(9) colony-forming units (cfu); all tolerated the dose and developed antibodies to fraction i of y. pestis. three immunized animals were challenged with an inhaled dose of 3.2 x 10(6) cfu (160 ld50 [50% lethal dose]) of virulent y. pestis strain 195/p and two survived ...	1977	402428
plague and pregnancy. a case report.		1977	576693
[effect of the digestive process on the survival of the plague agent in xenopsylla gerbilli minax fleas].	hystological investigations of experimentally infected x. gerbilli minax have shown that at the early stages of the digestion, while in the intestine compact clots of non-digested blood, are preserved, proceeds the reproduction of the plague agent. with the decay of the alimentary clot it changes into the dying off of the microbe population and after the ceasing of digestion the accumulation of bacteria renews again. simultaneously with the changes in the number of microbes their morphology vari ...	1977	593719
[lipopolysaccharides from a slightly virulent strain of yersinia pestis (author's transl)].		1977	923562
[flea ceratophyllus fasciatus as the vector of the altai-mountain strain of plague microbe].	the work was conducted with a typical strain of the plague agent, which is virulent to white mice and little virulent to guinea pigs (subcutaneous infection), and with c. fasciatus. the fleas of this species can be infected, form the block of proventriculus within 4 to 35 days, transmit the agent during bloodsucking to healthy animals and cause the death both white mice and guinea pigs.	1977	896271
evaluation of live attenuated plague vaccines in praomys (mastomys) natalensis.	a live attenuated yersinia pestis vaccine designated ev76-51f, which had previously been shown to be pathogenic in vervet monkeys but not in guinea pigs, was tested in the multimammate mouse praomys (mastomys) natalensis. doses of 10(6) viable organisms inoculated subcutaneously as either a lyophilized suspension or an agar-grown culture resulted in vaccination fatalities in praomys but not in white mice. hemagglutinating antibodies to the fraction 1 antigen were not stimulated by doses lower th ...	1977	908624