Publications

median rhomboid glossitis. candidiasis and not a developmental anomaly.	infection by candida albicans was found in all biopsies taken from ten patients presenting with midline lesions of the tongue which clinically presented as median rhomboid glossitis.	1975	1201190
binding of vitamin b12--rat transcobalamin ii and free vitamin b12 to plasma membranes isolated from rat liver.	when dialysed rat serum which contains a single, low molecular weight binder for vitamin b12, rat transcobalamin ii (rat tc-ii), was labelled in vitro with 57co-vitamin b12 and then incubated at 30 degrees c (ph 7-5) with vesicles of highly purified plasma membranes separated from microsomal fractions of rat liver by density gradient centrifugation, the 57co-vitamin b12-rat tc-ii complex bound to high affinity sites on the vesicles via a specific (binding after correction for 'non-specific' bind ...	1975	1201244
the functional consequences of colectomy.	the colon plays a decisive role in salt and water conservation in the intact human, normally removing from the terminal intestine approximately one liter of isotonic fluid that escapes small bowel absorption. the primary purpose of this colon function is probably to prevent extracellular fluid volume depletion and only incidentally to produce a normal solid stool. the patient with an ileostomy can partly adapt to replace the absorptive capacity lost after colectomy but is still vulnerable if sal ...	1975	1200267
yersinia pestis: correlation of ultrastructures and immunological status.	ultrastructural identification and localization of the fraction 1 "envelope" antigen in the plague bacillus yersinia pestis were the primary objectives of this brief study. the antigenicity of extra-cellular material between the bacilli in undisturbed cultured colonies and that of the pathogen per se were measured and correlated by means of the semi quantitative complement fixation method after incubation for 72 h at 37 c. when the amount of extracellular substance in wild-type t1 (virulent) bac ...	1975	1095487
exteroceptive suppression and motor control of the masseter and temporalis muscles in normal man.	single electrical stimuli to the gums and mucosa inside the mouth elicit two successive exteroceptive suppressions (es1 and es2) in the voluntary electromyogram of the masseter and temporalis muscles in normal man. the same afferent axons appear to be involved in the two effects, as indicated by the intensity function, the electrical excitability, the afferent conduction velocity and the lack of differential effect of xylocaine infiltration of the inferior alveolar nerve. two similar phases of i ...	1975	1111848
long-term effects of vasectomy on pituitary-gonadal function in man.	plasma concentrations of testosterone (t), follicle stimulating hormone (fsh), and luteinizing hormone (lh) and percent binding of t to plasma protein (tb) were studied in 16 normal fertile men and in 81 men who had undergone vasectomy from 1 to 5 yr earlier. no significant difference from the control values to t = 582 plus or minus 39.5 (se) ng/100 ml; fsh = 15.09 plus or minus 2.18 (se) miu/ml; lh =10.03 plus or minus 1.13 (se) miu/ml and tb = 92.99 plus or minus 0.285 (se) % binding was detec ...	1975	1168657
[electron microscopic study of double infection induced by potato virus x and potato virus y in nicotiana glutinosa].		1975	1214639
siderochrome production by yersinia pestis and its relation to virulence.	p+ plague strains contained more siderochrome-producing organisms than p-. siderochrome enhanced the mouse virulence of an f1+vw+p1+p-pu+ strains, inhibited p1 activity, and could be assayed by a paper disk titration method.	1975	1104486
blockade by morphine of acetylcholine release from the caudate nucleus in the mid-pontine pretrigeminal cat.		1975	1111819
free amino acids in human tonsillar tissue.	free amino acids in the tonsils of 20 individuals were measured column chromatographically. those always found in readily detectable amounts included o-phosphoserine, taurine, o-phosphoethanolamine, aspartic acid, hydroxyproline, threonine, serine, glutamic acid, proline, glycine, alanine, alpha-amino-n-butyric acid, valine, cystine, methionine, isoleucine, leucine, tyrosine, phenylalanine, ornithine, gamma-amino-butyric acid, lysine, histidine, and arginine. results were compared for three clin ...	1975	1112054
similar combining sites of igg1 and igg2a antibodies in individual mice as judged from affinity and rate constant measurements.	within individual sera, mouse igg1 and igg2a subclass antibodies against the antigenic determinant oligo-d-alanine are likely to have similar combining sites. the antibodies are characterized by two methods, by their rate of binding to antigen equipped sheep red blood cells and by the hapten inhibition of antigen binding. the two characteristics are shown to be independent. the subclass antibodies of thirteen different sera differ by a factor of about 10 in their rate constant and by a factor of ...	1975	1234045
[morphological and histochemical changes in the flea x. cheopis roths. infected with plaque bacilli].		1975	1113714
[electron microscopic studies of epinephrine choroiditis in rabbits. 3. scanning electron microscopic observations of the retinal pigment epithelial cells in the early stage (author's transl)].		1975	1239915
enzymatic formaldehyde production from 5-methyltetrahydrofolic acid: prior step to alkaloid formation.		1975	1125096
[litter effect on fetal toxicity test].		1975	1169531
influence of age and sex on the metabolism of oestrogens in mouse liver: in vitro perfusion of radioactive oestrone and oestradiol-17beta.		1975	1134094
cyclic kinetics and mathematical expression of the primary immune response to soluble antigen. vi. the possibility of prediction of plasma cell reaction in the spleen of mice immunized with soluble antigen.	a mathematical expression of the accumulation of the plasma cells in the spleen of cba mice immunized intraperitoneally is presented. the dependence of the plasma cell reaction in the spleen on the kinetics of antigen concentration in the blood was confirmed. for the transition from antigen to plasma cells, index a was proposed. the mean values of index a were used for comparison of the calculated and experimental values of the plasma cell reaction and the recorded differences were not great. in ...	1975	1176044
dietary fats and properties of endoplasmic reticulum: i. dietary lipid induced changes in composition of microsomal membranes in liver and gastroduodenal mucosa of rat.	rats were fed for four weeks with different lipid diets to determine the effects on the endoplasmic reticulum membranes of the liver and on the postmitochondrial supernatant fraction of the gastroduodenal mucosa. the diets contained cholesterol, cacao butter, olive oil, and these in combination. the results showed that dietary lipids were able to modify the composition of the hepatic endoplasmic reticulum and, to a lesser extent, that of postmitochondrial fraction of gastroduodenal mucosa. cacao ...	1975	1160521
comparative morphology of genital cones of genus ancylostoma dubini, 1843.	male worms of ancylostoma braziliense, a. ceylanicum, a. kusimaense, a. malayanum, a. duodenale, a. caninum, a. tubaeforme, agriostomum vryburgi and cyclodontostomum purvisi have the external appendages beside the anogenital aperture. these anogenital structures are morphologically similar and are assumed to be homologous among the species with three pairs of teeth or more. in hookworms with two pairs of teeth, the anogenital structures are complex. anogenital features can be used as a taxonomic ...	1975	1166351
letter: cryptic infection of rats with non-encapsulated variants of yersinia pestis.		1975	1145712
separation of phenylalanine transport events by using selective inhibitors, and identification of a specific uncoupler activity in yersinia pestis.	phenylalanine transport in yersinia pestis tjw was differentially inhibited by sulfhydryl blocking reagents, uncoupling agents, and respiratory inhibitors. kinetic studies with potassium cyanide and sodium azide showed that these compounds have no immediate effect on the initial rate of phenylalanine transport, but have an immediate and severe inhibitory effect on the rate of oxygen uptake. identical studies with p-chloromercuribenzoate (pcmb) and 2,4-dinitrophenol (dnp) showed that these compou ...	1975	1150617
the cardiac pharmacology of tolbutamide.	recent clinical studies have suggested an association of tolbutamide therapy with an increased incidence of cardiovascular deaths. due to the paucity of information concerning the acute cardiac actions of tolbutamide, the effects of this agent upon cardiac contractility and automaticity were examined under in vivo and in vitro conditions in rabbit, cat and dog heart muscle preparations. tolbutamide (10(-6) to 3 x 10(-3) m) produced a biphasic inotropic response with a peak positive inotropic res ...	1975	1151754
proceedings: the effect of tris on the response of various isolated, mammalian preparations to nerve and drug stimulation.		1975	1151799
serological studies on human plague in southern africa. part i. plague antibody levels in a population during a quiescent and a subsequent active period in an endemic region.	yersinia pestis fraction l passive haemagglutination studies on human sera obtained randomly during a plague epidemic showed a 10-fold increase in occurrence of antibodies compared with the results obtained on sera from the same population 11 months earlier during a quiescent phase. the pre-epidemic population antibody rate was lower than that in a comparable population tested simultaneously in another endemic region, where a recrudescence of plague was not experienced during the following year. ...	1975	1154171
[experience from a 30-year study of the stability of the properties of the plague vaccine strain ev in the ussr].		1975	1154937
a study of viral fever in the city of madras.		1975	1184536
plague and the gallium scan: case report.	inflammation in the right axillary lymph nodes and the meninges was detected by 67gacitrate scans in an 11-year-old boy with yersinia pestis infection. this case provides another example of 67ga localizing to areas of infection, indicating potential utility in future cases of bubonic plague.	1975	1185264
electrospinogram and spinal and cortical evoked potentials in experimental spinal cord trauma.	studies in 28 traumatized cats showed the following acute changes after spinal cord compression in the cord segment below the trauma: 1) increase in size of the spinal cord evoked potential; 2) increase in size of the electrospinogram; and 3) increase in frequency of the electrospinogram.	1975	1194940
[use of the brock punch for confection of a shunt between both ventricles, the ventricle and pulmonary artery or aorta without cardiopulmonary by-pass (cpb) (author's transl)].	use of the brock punch for placing a graft on the ventricle is a simple and easy technique not requiring cpb. this offers large experimental possibilities with clinical applications resulting from the experience gained in the laboratory.	1975	1199652
new inhibitors of methane production by rumen micro-organisms. experiments with animals and other practical possibilities.	1. two inhibitors of rumen methane production were given to sheep and their effects were measured using an in vitro technique. 2. the substances used were trichloroethyl pivalate (tce-p) and trichloroethyl adipate (tce-a). in one experiment with two sheep tce-p was injected into the rumen and in another experiment with two sheep the same inhibitor was mixed with the food just before feeding. in another experiment, tce-a was given to two sheep at two dose levels, and in an experiment with four sh ...	1975	1201268
proceedings: anaesthetics in porphyria: intravenous induction agents.		1975	1201181
methionine transport in yersinia pestis.	yersinia pestis tjw, an avirulent wild-type strain, requires phenylalanine and methionine for growth. it was of interest to examine and define the methionine transport system because of this requirement. the methionine system showed saturation kinetics with a km for transport of approximately 9 times 10(-7) m. after 8 s of methionine transport, essentially all of the methionine label appeared in s-adenosyl-l-methionine (sam) as detected in ethanol extracts. small amounts of free methionine was d ...	1975	1176434
polypectate digestion by yersinia.	the ability of yersinia to digest polypectate may be of some value in differentiating y. enterocolitica and y. pseudotuberculosis from some of the other fermenting gram-negative bacilli, such as enterobacter agglomerans, with which they can be confused. pectolytic activity in yersinia may also have some teleologic or taxonomic significance about which we do not care to speculate.	1975	1206110
[sensitivity of inbred mice to the causative agent of plague].		1975	1210890
[variety of effects of vitamins on yeast cells in aerobic conditions].	the effect of thiamine and biotin on the processes of cell division, assimilation of glucose, and accumulation of the biomass and nitrogen in the cells was studied with the candida yeast. the action of the vitamins depended on the source of nitrogen. in some strains, asparagine can substitute for biotin. biotin has different effect on the production of gamma-aminobutyric acid in candida pulcherrima, c. guilliermondii. c. tropicalis k3-10. high concentrations of arginine were found in c. guillie ...	1975	1214604
[effect of the prolonged contact of a flea population with plague bacteria on the infective activity of vetors].	results of the experimental infection of fleas (x. cheopis) with the plague agent after their long (2.5 years, 19 generations) feeding on infected white mice showed no difference in the infection activity of these insects as compared to control ones. the authors question the hypothesis according to which a low frequency of protein-formation in some species of fleas is due to their long contact with the plague agent in the historical past.	1975	1221343
[isolation and properties of several auxotrophic mutants of a highly virulent strain of the plague microbe].	2432 stable auxotrophic mutants were selected from high virulent yersinia pestis strain 20b after treatment with nitroso guanidine. they were deficient in amino acids (arginine, aspartic acid, citrulline, glycine, glutamic acid, histidine, isoleucine, serine, leucine, lysine, ornithine, proline, tryptophan, tyrosine, valiney, pyrimidine and vitamins (riboflavin, thyamine, nicotinamide). some mutants were two- and three-fold dependent. the leucine-, histidine-, purine-dependent mutants were isola ...	1975	1225753
cat bite transmission of yersinia pestis infection to man.	the transmission of bubonic plague from the kitten of a domestic cat to a man by means of a bite on a finger is described. the human case was complicated by the development of a secondary meningitis, followed, after specific therapy, by protracted recovery. the kitten showed swollen lymph nodes of the head and neck, frothing at the mouth and nostrils, and signs of an acute infectious disease which had a fatal termination. yersinia pestis was isolated on about the 8th day from the cerebrospinal f ...	1975	1238568
[isolation and properties of several auxotrophic mutants of a highly virulent strain of the plague microbe].	2432 stable auxotrophic mutants were selected from high virulent yersinia pestis strain 20b after treatment with nitroso guanidine. they were deficient in amino acids (arginine, aspartic acid, citrulline, glycine, glutamic acid, histidine, isoleucine, serine, leucine, lysine, ornithine, proline, tryptophan, tyrosine, valine), pyrimidine and vitamins (riboflavin, thyamine, nicotinamide). some mutants were two- and three-fold dependent. the leucine-, histidine-, purine-dependent mutants were isola ...	1975	1232031
the efficiency of aquocobalamine as an antidote in cyanide poisoning when given alone or combined with sodium thiosulfate.	the antidotal activities of aquocobalamineacetates and sodium thiosulfate were tested in guinea pigs and cats. the animals were attached to artificial respirators throughout the experiment and were poisoned with a continuous infusion of sodium cyanide solution (4.1 mumol/kg.min nacn). the rate of action of each antidote was determined from the time taken for the hcn exhalation to drop below the level of 100 nmol/kg.min in quinea pigs, and to values below 25 nmol/kg.min in cats; the detoxifying c ...	1975	1242295
[determination of human placental lactogen in the blood of pregnant women by rcc-hpl-ria kit--experimental studies].		1975	1240044
analysis of rna and protein synthesis in temperature-sensitive mutants of tetrahymena pyriformis.		1975	415226
clinical problems. part 2: evaluating patients with acute chest pain.		1975	246159
protocol: assessment and management of angina pectoris.		1975	246158
[use of erythrocyte diagnostic agents for the determination of integrative association constants].	the authors described a method of determination of integrative association constant differing from intrinsic association constant by the value of the valency of macromolecular antigen. the method is based on the using of erythrocytes on whose surface one of the components is fixed, whereas the other is in free state. application of equations was demonstratedon a number of examples with determination of integrative association constant. the data obtained permitted to assess qualitative peculiarit ...	1976	1266452
yersinia pestis infection in vietnam. ii. quantiative blood cultures and detection of endotoxin in the cerebrospinal fluid of patients with meningitis.	quantitative blood cultures were obtained from 42 patients with acute yersinia pestis infection to determine whether the concentration of bacteria in blood influenced the clinical severity and outcome of illness. in 17 bacteremic patients, colony counts in blood cultures ranged from less than 10 to 4 x 10(7)/ml. three of five patients with colony counts of greater than 10(2)/ml died, and two patients survived episodes of hypotension. results from plasma limulus tests were positive at the time of ...	1976	1262715
[cryosurgery of the esophagus and the cardia in animal experiments].		1976	1272986
separation of two hepatitis b human antibody fractions by cold-ethanol precipitation.	antibodies to three different samples of hepatitis b antigen-positive serum were found to be absent from a cohn fraction ii hepatitis b immune globulin preparation, but present in the whole plasma from which the immune globulin was made. fractions containing the antibodies specific for the three antigen samples were isolated from the plasma by euglobulin precipitation, and the antibodies were characterized as to immunoglobulin class and precipitability in the cohn fractionation procedure. they a ...	1976	1251569
the effect of subdermal testosterone filled polydimethylsiloxane implants on spermatogenesis in rhesus monkeys (macaca mulata).	previously it was reported that testosterone-filled polydimethyl silicone (pds) implants induced azoospermia in male rabbits without chronically altering plasma testosterone concentration or the weight or secretory activity of accessory sex glands. assayable serum luteinizing hormone (lh) and testicular testosterone secretion were completely suppressed. testosterone emanating from the pds capsule maintained libido but failed to support spermatogeneis in the rabbits. to test results in subhuman ...	1976	1261261
new assay for pregnenolone and progesterone 17alpha- hydroxylase based on the specific substitution of a tritium situated on carbon 17.	a new assay for the measurement of steroid 17alpha-hydroxylase activity in beef adrenals is described. this method is based on the biochemical mechanism of the enzymic reaction, i.e. the direct and stereospecific substitution of the proton located on the hydroxylated position. progesterone or pregnenolone specifically labelled on the 17 position are solubilized in the incubation mixture with the help of tween 80 and incubated under optimal conditions. the tritium enzymically released from the su ...	1976	1248468
the detection of antibodies in human and animal filariases by counterimmunoelectrophoresis with dirofilaria immitis antigens.	counterimmunoelectrophoresis revealed the presence of precipitin antibody in all of 6 dogs and the 1 cat infected with dirofilaria immitis and in the serum of 17 of 24 individuals living in a setting of hyperendemic subperiodic bancroftian filariasis. antigens used in the test were prepared from microfilariae and adult male d. immitis. some humans and animals had antibodies to both antigens while others had antibodies against microfilariae or adult worms only. the presence of soluble circulating ...	1976	1262695
attenuated, streptomycin-dependent salmonella typhi oral vaccine: potential deleterious effects of lyophilization.	four studies were done with streptomycin-dependent salmonella typhi as an oral, attenuated vaccine. studies 1 and 3 employed freshly harvested vaccine, whereas studies 2 and 4 involved lyophilized vaccine. five to eight doses (3 x 10(10)-10(11) organisms/dose) were given; oral streptomycin (1.0 g) was administered concomitantly in studies 2 and 3, with only two of the doses of vaccine in study 1, and was not given in study 4. no adverse reactions were encountered in 179 vaccinated men, and 94% o ...	1976	1262709
the toxic effects of dieldrin in rats: a reevalution of data obtained in a two-year feeding study.		1976	1273845
the isolation and identification of noradrenaline and dopamine from the venom of the honey bee, apis mellifica.		1976	1273857
[changes in the activity of succinate dehydrogenase in the cells of different brain structures under the effect of uhf field of low intensity].		1976	1274298
glial cells and extracellular potassium: their relationship in mammalian cortex.	simultaneous recordings were made of glial cell potentials and the extracellular potassium concentration ([k+]o) in cat cortex in an attempt to provide more quantitative information about the sensitivity of mammalian neuroglia to changes in [k+]o. a penicillin epileptogenic focus served to generate both transient and sustained elevations in [k+]o, thus allowing measurement of glial membrane potential (vm) at both resting and increased [k+]o levels many times during the same experiment. resting v ...	1976	1276917
[effect of certain factors on block formation in ceratophillus tesquorum and neopsylla setosa setosa].	studies were conducted of the effect of temperature and humidity, variant of plague microbe, frequency and duration of feeding and specificity of the host on the blockformation in the souslik fleas c. tesquorum and n. setosa infected with plague. 28 tests on the effect of temperature and humidity on the blockformation were undertaken, for which 14411 fleas of the above species were used. a temperature of 16 to 22 degrees proved to be optimal; at this temperature the number of blocked fleas (c. t ...	1976	958724
distribution of plague in rhodesia as demonstrated by serological methods.		1976	963738
trapping and serum testing of rodents caught prior to the outbreak of plague in rhodesia.		1976	963739
identification of multiple cytolytic components associated with the beta-lt class of lymphotoxins released by mitogen-activity human lymphocytes in vitro.	cytotoxic activity (lymphotoxin (lt) associated with the 50,000 dalton beta-lt class of human lymphotoxins has been resolved into multiple components by chromatography on deae-cellulose or electrophoresis on polyacrylamide gels. the two components, termed beta-lt, and beta-lt2, are separable from the 90,000 m.w. alpha-lt, since neither component is neutralized by incubation with heterologous rabbit anti-alpha-lt antisera. however, the two components differ in their overall charge and relative he ...	1976	1087315
nystagmic modulation of neuronal activity in rabbit cerebellar flocculus.	1. the responses of neuronal elements in the flocculus of the awake, restrained rabbit were recorded during horizontal vestibular nystagmus in the dark. 2. purkinje cells showed both vestibular (types i and ii) and eye movement modulation of simple spike activity. type i purkinje cells most commonly were inhibited in association with the ipsilaterally directed fast phase of nystagmus and excited during contralaterally directed fast phases. type ii purkinje cells had a similar modulation but in t ...	1976	1087403
polymorphism of human color vision.	the genetic polymorphism of human color vision is examined within the framework of a photopigment replacement model. an analysis of the x-linked recessive dichromacies and anomalous trichromacies indicates that one source of variability of normal color perception may be the inclusion of several distinct phenotypes in what is usually described as normal color vision. this analysis also reveals the cause of the dominance hierarchy at the protan and deutan loci, the perceptual effects of dosage com ...	1976	1087832
a comparison of serological tests for detecting antibody to plague.	a study was undertaken of the relationship between the passive haemagglutination and haemagglutination inhibition tests used in serum surveys for specific plague antibodies. both techniques gave similar titres for sera of albino rattus norvegicus convalescent from plague infection. they appear to be equally suitable for plague surveillance and control programmes.	1976	1088106
familial clustering of selective iga deficiency.	serum iga levels of 35 healthy iga-deficient index cases, of their 180 first-degree relatives, and of 31 other family members were studied. iga deficiency was detected in 7.2% of the first-degree relatives, which is significantly more than the 0.25% frequency of iga deficiency in healthy finnish blood donors. subnormal serum iga levels were found in additional 13 (7.2%) first-degree relatives. the familial clustering of iga deficiency seemed to be controlled by multigenic factors. iga-deficient ...	1976	1251582
[diagnostic problems in gout in a 44-year-old man].		1976	1251615
some factors influencing the damaging effect of acute arterial hypertension on cerebral vessels in rats.	1. abrupt increase of arterial blood pressure can give rise to multifocal areas of protein extravasation in the brain due to overstretching of the vessels. 2. the vascular tone of the resistance vessels is of importance for the occurrence of the increased permeability. 3. vasodilatation aggravates the damaging effect of acute hypertension whereas vasoconstriction induced by hyperventilation reduces the incidence of areas of increased permeability. 4. ligation of a carotid artery prevents lesions ...	1976	1071656
[the effects of enzymes and secretions of the gastrointestinal tract on the eb vaccine strain].	experiments were conducted in vitro. a study was made of the action of the enzymes and of the secretions of the gastrointestinal tract on the viability of the eb vaccine strain. sensitivity of bacterial cells to the action of saliva, gastric juice, intestinal contents, trypsin, and bile proved to differ. gastric juice inactivated the vaccine strain which expressed a satisfactory resistance towards the rest of the factors under study practically immediately. there were revealed no significant mor ...	1976	1034388
biological consequences of incorporation of 5-fluorocytidine in the rna of 5-fluorouracil-treated eukaryotic cells.	treatment of hela cells with 5-fluoro-[3h]uracil leads to the incorporation into cellular rna of 5-fluorocytidine to the extent of about 0.2% of the 5-fluorouridine incorporated. in tobacco mosaic virus rna produced in tobacco leaves this ratio is one order of magnitude lower. copolymers of cytidylic with 5-fluorocytidylic acids show unchanged template activity with e. coli rna polymerase, but slightly altered messenger activity in the wheat germ system, compared to poly(c), and it is suggested ...	1976	1064021
presence of messenger specifying sequences in the dna of chromatin subunits.	messenger-specifying sequences in subunits of human lymphocyte chromatin were detected by hybridization of dna complementary to cytoplasmic polyadenylylated rna with dna isolated from the subunits. comparison of the kinetics and extents of hybridization of complementary dna with chromatin subunit dna and with nuclear dna showed that most of the repetitive sequences and single copy sequences in mrna are present in chromatin subunits. this result indicates that inclusion of a dna sequence into the ...	1976	1064026
hypersensitivity to tobacco antigen.	a glycoprotein of molecular weight 18,000 was purified from saline extracts of cured tobacco leaves by ammonium sulfate fractionation, chromatography on sephadex g-25 and continuous-flow preparative electrophoresis on polyacrylamide gel. twelve of 31 volunteers (6/15 smokers and 6/16 nonsmokers) exhibited immediate cutaneous hypersensitivity (wheal and flare reactions) when injected intracutaneously with 2 mug of this material. immunochemically similar material was demonstrated in, and purified ...	1976	1064042
bubonic plague from direct exposure to a naturally infected wild coyote.	an 11-year-old boy developed axillary bubonic plague and plague meningitis 3 days after skinning a dead coyote near albuquerque, new mexico. the coyoto carcass was recovered 10 days later, and yersinia pestis was isolated from spleen and marrow of the animal. this is the first report of human plague from exposure to a coyote. a review of experimental and epidemiologic studies suggests that severe plague infection in members of the family canidae is unusual, and that the risk of acquiring plague ...	1976	961983
[study of the effect of tetracycline, prodigiosin and their combination on the dynamics of phagocytosis of plague bacteria].	the advantage of the combined use of prodigiozan and tetracycline was observed in tissue culture of peritoneal macrophages of albino mice. earlier digestion of the intracellular y. pestis ev by the animal macrophages exposed to prodigiozan and treated with tetracycline was noted. it was shown that the macrophages preserved during several hours of cultivation in vitro their properties acquired in the animal organism under the effect of the substances administered.	1976	1023817
serological studies on human plague in southern africa. part ii. a bubonic/pneumonic plague epidemic in lesotho.	a description is given of an outbreak of human plague in lesotho in 1968 which was preceded by, and merged with, a typhoid epidemic. this circumstance was responsible for a diagnosis of typhoid fever being made in the earliest plague cases, especially as the clinical presentation was similar to that of the typhoid patients. consequently, the plague epidemic ran its natural course and with the onset of winter the pneumonic form appeared. serological follow-up studies of recovered patients were ca ...	1976	935988
bubonic plague from exposure to a rabbit: a documented case, and a review of rabbit-associated plague cases in the united states.	a 62-year-old woman developed bubonic plague with an epitrochlear bubo one to two days after skinning two cottontail rabbits. the implicated rabbits were later recovered from the patient's freezer, and yersinia pestis was isolated from marrows of both rabbits. although human plague cases in the united states have occasionally been traced to exposure to wild rabbits, this is the first documentation of plague infection in the actual rabbits to which the patient was exposed. all reported cases of r ...	1976	937344
[method for the quantitative determination of penicillin acylase activity by the formation of phenylacetic acid].	the quantitative method for determination of penicillinacylase activity is described. the method is based on detection of phenylacetic acid (paa) formed during hydrolysis of benzylpenicillin. paa is extracted with toluol and nitrated with potassium nitrate solution in concentrated sulphuric acid followed by reduction of nitrophenylacetic acid into aminophenylacetic acid with zinc powder. aminophenylacetic acid interacts with p-dimethylaminobenzaldehyde in acid medium forming a coloured compound ...	1976	793510
[arthropodan vectors of human parasites: their pathology and defence reactions (author's transl)].	many infectious diseases of man are transmitted by arthropods. it is not known whether the carriers were primarily susceptible or insusceptible as the cycle first came into existence. similarly so little is understood, why some arthropods are suitable vectors and other close relatives are not suitable. only the hypothesis that the agents are original parasites and not at all commensals or symbionts can reasonably explain the evolution of the cycles. it is shown by means of numerous examples how ...	1976	769379
ampicillin-resistant hemophilus sp.		1976	1082793
[influence of substances that change the serotonin level of the brain on the analgesic effect of promedol in rats].	in tests with determination of pain reaction in rats registered by their squeak and arising in reponse to a single electric irritation of the tail evidence was obtained to the effect that substances both lowering the serotonin content in the brain (p-chlorphenylalanine, reserpine) and raising it (5-oxytryptophan, pargilin) cause a fall of the threshold, viz. 5-oxytryptophan and pargilin display antagonism to the analgetic effect of trimeperidine hydrochloride, whereas p-chlorphenylalanine, and i ...	1976	1082823
production of antibody in induced granulomas.	a method of producing antibodies in artificially induced granulomas with various microbial antigens is examined.	1976	789397
[lytic activity of anti-plaque bacteriophages in the face of various strains of escherichia coli].		1976	791533
[long-term cardiac arrest by cardioplegic coronary perfusion (author's transl)].	the mg++ aspartate-procaine-cardioplegia has been proven in animal experiments as well as from 1970 til 1975 in more than 1000 open-heart-procedures by a myocardial temperature of 32 degrees c and aortic crossclamping time up to 40 minutes superior to all other known procedures of cardiac preservations. to guarantee a safe myocardial protection of the arrested heart for a remarkable longer period of total ischemia, we further developed the cardioplegic technique in the animal lab, and use it now ...	1976	1087482
[lysogenic clones of wild-type plague bacteria and characteristics of the phages produced by them].	comparative population analysis of 3 lysogenic clones of plague bacteria of wild type by lysogenic properties demonstrated that they failed to show any difference from one another by immunity to homolgous and heterologous phages, but differed by the number of cells capable of producing the phage spontaneously. lysogenic properties were transmitted by heredity both after the ten-fold passage in the presence of a homologous antiphage serum and after a 10-fold colning. phages produced by the wild l ...	1976	961226
immunity in plague: protection induced in cercopithecus aethiops by oral administration of live, attenuated yersinia pestis.	a live, attenuated yersinia pestis vaccine, designated ev76 (paris) f, was pathogenic in cercopithecus aethiops when administered parenterally. although an oral dose of 10(9) colone-forming units of the vaccine was nonfatal to vervets, a transient but severe gastrointestinal disturbance resulted in four of 12 animals. seven immunized vervets were protected against intradermal challenge. the remaining five vervets without serologic reactions and five untreated controls died from typical bubonic ( ...	1976	815445
[results of verifying the hypothesis of the constant passage of the plague causative agent on a mathematical model].		1976	781502
[stabilization of the immunogenic properties of vaccinal strains of bacteria].		1976	790870
[studies of yersinia pestis in wild animals captured in ankara, konya and nevsehir].	no yersinia pestis could be isolated, by culturing and by inoculations to 1212 guinea-pigs and 150 mice; from 623 citellus, 41 mus musculus, 55 microtus, 442 meriones, 70 rattus rattus, 56 turtle, 89 hare, 1 hamster, 1 hedgehog, 1 sea snake, altogether 790 dead, 589 alive, i.e. 1379. wild animals captured in ankara, konya (karapinar), urfa (akçakale) and in nevşehir. in 141 sera taken from citellus captured alive, and in 174 sera taken from guinea-pigs inoculated with spleen, liver and kidney su ...	1976	933892
[normal antibodies and immunologic reactivity].	antibodies to the capsular antigen of plague causative agent were found in the serum of many nonimmunized mice of 6 strains, but none were found in mice of the dba/2 strain. after the administration of the capsular antigen to mice of different strains cells forming the antibodies to the antigen administered were revealed in a quantitative correlation with the natural antibody level. an association was revealed between the level of natural antibodies and the number of antibody-forming cells in th ...	1976	986741
[study of the penicillinase of the plague microbe, the synthesis of which is determined by the r-episome].	penicillinase produced by a culture of the plague microbe with episomic resistance to benzylpenicillin was isolated and purified. comparative investigation of the substrate spectrum, michaelis constant and antigenic properties of the enzymes from the plague and dysentery microbes (r-factor donor) showed that transfer of the r-episome to the new host did not affect the investigated properties of penicillinase the synthesis of which was controlled by this episome.	1976	999263
[electron microscopic study of dry live plague vaccine eb by the scanning method].	dry live plague vaccine eb was examined under microscope; it appeared that in the mentioned preparation the bacterial cells were enclosed in the artificial sucrose-gelatin capsule of the stabilizer which apparently maintained the vital activity of the microorganisms in the state of anabiosis by forming a stable bond with the bacterial body.	1976	1007728
[enzymomorphology of the vaccinal process in connection with formation of immunity to plague].	the studies conducted showed that the beginning of immunogenesis following the administration of live plague vaccine was preceded by a period of primary toxic action of multiplying microbes when the activity of a number of enzymes in the organs of guinea-pigs was temporarily reduced. subsequently, inductive and productive phases of formation of antibodies started against the background of normalization and growth of the enzymatic activity associated with mobilization of energy. the earliest hype ...	1976	194554
hepatocyte perfusion within a centrifuge.	a centrifuge, as used in blood banks for washing erythrocytes, is shown to be a good perfusion chamber for hepatocyte suspensions being evaluated for potential extracorporeal liver support. the perfusate was cell-free oxygenated--po2 300 millimeters of mercury--plasma, serum or tissue culture medium. a centrifuge that requires intermittent perfusion cannot deliver sufficient oxygen to maintain prolonged viability. a continuous flow unit can, at a flow of 800 milliliters per minute, support most ...	1976	173032
investigations on adenosine 3',5'-monophosphate phosphodiesterase in ram semen and initial characterization of a sperm-specific isoenzyme.	phosphodiesterase is shown to occur in ram semen, and its activity to be higher in spermatozoa than in seminal plasma. using similar substrate levels, the rate at which adenosine 3',5'-monophosphate (cyclic amp) is metabolized by phosphodiesterase in spermatozoa is about 100 times higher than that of cyclic amp synthesis by adenylate cyclase. in spermatozoa, phosphodiesterase is present partly in a soluble form, and partly bound; both forms can be extracted by sonication. the soluble enzyme (ph ...	1976	178869
light and electron microscopic features of a pituitary adenoma in nelson's syndrome.	electron microscopy of an amphophil pituitary adenoma surgically removed from a 51-year-old woman who had nelson's syndrome revealed that the tumor was composed of melanocorticotroph cells. this finding is consistent with the view that in the human pituitary gland one single cell type produces both adrenocorticotropic hormone (acth) and melanocyte-stimulating hormone (msh). in contrast to the ultrastructure of pituitary adenomas associated with cushing's syndrome, no or only very few microfilame ...	1976	176883
[chronic granulomatous disease. clinical symptoms and biochemical background].		1976	184401
disseminated herpesvirus infection. association with primary genital herpes in pregnancy.	a patient with primary herpes simplex virus (hsv) type 2 genital infection had dissemination in the 37th week of her first pregnancy. this was manifested by severe hepatitis, pancreatitis, and genital lesions. temporary improvement followed the delivery of a healthy infant by cesarean section. encephalitis became evident on the third postpartum day, and recovery was complicated by profound bradycardia, possibly due to viral myocarditis. vidarabine was administered for seven days, and the patient ...	1976	178938
a microtiter solid-phase radioimmunoassay for hepatitis a antigen and antibody.	a microtiter solid phase radioimmunoassy for hepatitis a antigen (ha ag) and antibody (anti-ha) was developed. the test was more sensitive than immune adherence hemagglutination for detecting ha ag and almost as sensitive for detecting anti-ha. the specificity and sensitivity of reagents were examined and optimum conditions for the test were determined. radioimmunoassay, immune adherence hemagglutination, and immune electron microscopy were compared for detecting anti-ha. a serologic response to ...	1976	175117
pituitary regulation of human growth hormone binding sites in rat liver membranes.	we have studied the binding of 125i-human growth hormone (hgh) to crude 100,000 x g membrane preparations from rat liver, and have studied factors which might regulate the capacity and affinity of hgh binding sites. membrane preparations have livers of pregnant rats bound between 8% and 18% of the 125i-hgh initially added, and 70%-80% of that bound was displaced by 1 mug of unlabeled hgh. humans prolactin (hprl) displaced 125 i-hgh in a manner parallel to hgh itself but with about one-third the ...	1976	175242
early effects of inorganic lead on immature rat brain mitochondrial respiration.	inorganic lead, added to the diet of suckling rat in high doses, produces an encephalopathy similar to that seen in the immature human. pathologic changes of edema and hemorrhage are seen earliest and are most prominent in the cerebellum. in this study, we measured respiration in cerebral hemisphere and cerebellar mitochondria isolated from led-fed and age-matched normal rat pups. lactating mothers were begun on ad libitum feedins containing 4% lead carbonate when their pups were 2 weeks old. mi ...	1976	174053
broader investigation into the external environment of the specific antigen of the infectious agent in epizootiological observation and study of the structure of natural foci of plague.	the possibilities of detection of the infectious agent in natural foci of plague can be expanded to some extent by using the method of search for the specific fi capsular antigen of the plague microbe in such objects of the external environment which have not yet been subjected to laboratory analysis and serological analysis in particular. such objects include soil from the burrow and the substrate of the nest of the rodent as well as the fleas of rodents and regurgitations of birds of prey. the ...	1976	135026
intracellular forms of epstein-barr virus dna in human tumour cells in vivo.	tumour biopsies from burkitt lymphoma patients, as well as human nasopharyngeal carcinoma cells growing in athymic mice, contain epstein-barr virus dna as covalently closed circular dna. in addition integrated viral dna sequences seem to be present.	1976	176597