Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| endosulfan induced inhibition of 3h-5-hydroxytryptamine uptake in platelets. | endosulfan, a chlorinated pesticide, is widely used to control various insect pests. rats exposed to 1 mg and 3 mg endosulfan/kg for periods of 10, 30, and 60 days showed significant (p less than 0.05) inhibition of [3h]5-hydroxytryptamine (5-ht) uptake by platelet-rich plasma (prp) in an ex vivo study. rats treated with endosulfan (1 and 3 mg/kg) up to 60 days elucidated a marked inhibition of adp-induced aggregatory responses of the platelets. incubation of prp with 10 microm and 100 microm en ... | 1986 | 3775804 |
| myoelectric correlates of colonic motor complexes and contractile activity. | 1986 | 3777176 | |
| changes in regional myocardial perfusion by muscarinic receptor subtypes in dogs. | to determine the muscarinic receptor subtype (m1 or m2 or both) responsible for cholinergic coronary vasodilatation and alterations in the transmural distribution (endocardial to epicardial blood flow ratio) of coronary blood flow, systemic and coronary haemodynamic indices and regional myocardial blood flow (radioactive microspheres) were measured in anaesthetised dogs. submaximal vasodilative doses of the mixed muscarinic agonist acetylcholine were given by intracoronary infusion to avoid peri ... | 1986 | 3779744 |
| estimation of regional gas and tissue volumes of the lung in supine man using computed tomography. | this study was intended to discover how well computed tomography could recover the volume and weight of lung like foams in a body like shell, and then how well it could recover the volume and weight of the lungs in supine man. model thoraces were made with various loaves of bread submerged in water. computed tomography scans recovered the volume of the model lungs (true volume range 250-12,500 ml) within +0.2 (sd 68) ml and their weights (true range 72-3125 g) within +30 (78) g. scans also recov ... | 1986 | 3787544 |
| 1h-nmr assignments and the dynamics of interconversion of the isomeric forms of cytochrome b5 in solution. | cytochrome b5 reconstituted with specifically deuterated hemins has led to the assignment of the resolved 6,7 beta-propionate protons and heme meso protons. freshly reconstituted cytochrome b5 contains a mixture of two isomers in an approx. 1:1 ratio. as time proceeds the minor isomer decreases in intensity until the equilibrium ratio, approx. 8:1, of the two isomers is reached. the rate of the heme disorder kinetics was investigated for cytochrome b5 as a function of ph, oxidation state and 2,4 ... | 1986 | 3790573 |
| 1h-nmr assignments and the dynamics of interconversion of the isomeric forms of cytochrome b5 in solution. | cytochrome b5 reconstituted with specifically deuterated hemins has led to the assignment of the resolved 6,7 beta-propionate protons and heme meso protons. freshly reconstituted cytochrome b5 contains a mixture of two isomers in an approx. 1:1 ratio. as time proceeds the minor isomer decreases in intensity until the equilibrium ratio, approx. 8:1, of the two isomers is reached. the rate of the heme disorder kinetics was investigated for cytochrome b5 as a function of ph, oxidation state and 2,4 ... | 1986 | 3790573 |
| glucose regulation of cephamycin biosynthesis in streptomyces lactamdurans is exerted on the formation of alpha-aminoadipyl-cysteinyl-valine and deacetoxycephalosporin c synthase. | glucose exerted a concentration-dependent negative regulation on the biosynthesis of cephamycin c by streptomyces lactamdurans. formation of the cephamycin precursor delta(alpha-aminoadipyl)-cysteinyl-valine was greatly decreased by excess glucose. the ring-expanding enzyme deacetoxycephalosporin c synthase was strongly repressed by glucose in vivo. isopenicillin n synthase (cyclase) and isopenicillin n epimerase were not repressed by glucose. however, the activity of isopenicillin n synthase wa ... | 1986 | 3794640 |
| suppression of free fatty acids and triglycerides in normal and hypertriglyceridemic rats by the adenosine receptor agonist phenylisopropyladenosine. | activation of adenosine receptors leads to the inhibition of lipolysis in the fat cells of several species including humans. we have examined the effects of the adenosine analog phenylisopropyladenosine (pia) on lipolysis in vivo in intact rats. pia suppresses markedly serum-free fatty acid (ffa) concentrations when injected s.c. (-)-pia is more potent than (+)-pia in suppressing ffa concentrations; also, this effect of (-)-pia is blocked by the adenosine receptor antagonist 8-(p-sulfophenyl)the ... | 1986 | 3795036 |
| effect of clofibrate feeding on some lipogenic enzyme activities induced by high carbohydrate diet. | clofibrate administration by stomach tube or intraperitoneally for 3 successive days to rats fed standard diet or starved for 72 hr caused about 2-fold increase of malic enzyme activity in the liver and adipose tissue. the drug administered by stomach tube (but not intraperitoneally) to the rats fed fat free-high carbohydrate diet significantly blocked the inducing effect of the diet on malic enzyme activity in both tissues. clofibrate blocked the induction by fat free-high carbohydrate diet of ... | 1986 | 3801034 |
| cloning of the rfb gene region of shigella dysenteriae 1 and construction of an rfb-rfp gene cassette for the development of lipopolysaccharide-based live anti-dysentery vaccines. | recent studies have shown that determinants for the production of o antigen lipopolysaccharide in shigella dysenteriae 1 are distributed over two distinct genetic elements, the chromosome and a 9 kb plasmid designated phw400. in this communication, we describe the cloning of all determinants necessary for s. dysenteriae 1 o antigen production in e. coli k-12 and their combination in a single plasmid. an rp4::minimu r-prime plasmid, r-prime 40, containing the his-rfb (histidine biosynthesis-lipop ... | 1986 | 2469931 |
| genetic and biochemical analysis of shigella dysenteriae 1 o antigen polysaccharide biosynthesis in escherichia coli k-12: 9 kb plasmid of s. dysenteriae 1 determines addition of a galactose residue to the lipopolysaccharide core. | production of the somatic antigen, o-specific polysaccharide of shigella dysenteriae 1 is determined by the chromosomal rfb gene cluster and the rfp gene located on the 9 kb plasmid phw400 carried by this organism. when transferred to escherichia coli k-12, which produces lipopolysaccharide consisting only of core oligosaccharide linked to lipid a, rfp gene-containing plasmids caused modification of the core oligosaccharide leading to the appearance of core molecules with new electrophoretic mob ... | 1986 | 2469932 |
| genetic and biochemical analysis of shigella dysenteriae 1 o antigen polysaccharide biosynthesis in escherichia coli k-12: structure and functions of the rfb gene cluster. | the genetic organization and functions of the shigella dysenteriae 1 rfb gene cluster, which specifies the somatic o antigen in this organism, have been studied in escherichia coli k-12 by insertion and deletion mutagenesis of pss9, a pbr322 hybrid containing the shigella rfb genes. on the basis of the sensitivity/resistance to rough-specific bacteriophage t3 of e. coli k-12 derivatives containing mutant pss9 plasmids, of the banding patterns and immunoreactivity of lps isolated from such deriva ... | 1986 | 2469933 |
| dysentery: an overview. still problems to resolve. | this article reviews the global situation with regard to bacillary dysentery, with particular emphasis on findings from the recent epidemic in west bengal. infection is by the fecal-oral route and generally spread by person-to-person transmission. serious epidemics caused by the multiple-drug-resistant shigella shigae have occurred recently in bangladesh, somalia, south india, burma, sri lanka, nepal, bhutan, rwanda, and zaire. in each situation, dysentery attacked over 10% of the population ... | 1986 | 12341664 |
| accidental intrathecal administration of vincristine. | vincristine is a chemotherapeutic agent used in the treatment of various neoplastic diseases. its neurotoxicity after therapeutic and pharmacologic doses has been well documented. we report a case of accidental intrathecal administration of vincristine in order to describe the complications seen, discuss possible means of therapeutic intervention, and serve as a reminder that preventive measures are mandatory to avoid such accidents in the future. | 1986 | 284172 |
| [morphological substrate of antalgia and analgesia in the odontostomatological and facial area]. | prior personal work is further extended by a description of the way in which odontostomatological and facial pain is sedated by acupuncture: via peripheral receptors, whose stimulations are intercepted and modulated by various filters lying between the periphery and the cortex: cord (gelatinous substance of rolando, gate control system), reticular formation and thalamocortical pathways. | 1986 | 180459 |
| nursing care study: a personality disorder in an adolescent with cerebral palsy. | 1986 | 260087 | |
| [the relation at the time of discharge from hospital: the relation at the time of discharge through the activities in visiting/nursing - focusing on the complaints of patients and their family]. | 1986 | 214614 | |
| some medical customs of the cocos-keeling islanders. | 1987 | 260680 | |
| [the morbidity rate of pulmonary tuberculosis among the military police of the state of são paulo (1958-1975)]. | 1987 | 305089 | |
| [late results of vestibuloplasty in the comprehensive treatment of periodontal diseases]. | 1987 | 265836 | |
| tumours and viruses in mice injected with plutonium. | 1987 | 266117 | |
| poor communication: a barrier to change. | 1987 | 260325 | |
| pneumonia--the quality of medical records data. | the quality of medical records data for patients who were hospitalized with community-acquired pneumonia was assessed by comparing medical records data with data obtained in a prospective study of pneumonia for the period april 1, 1984, to december 31, 1984. one hundred five patients fulfilled the case definition of pneumonia for entry into the prospective study. one hundred twenty-seven patients were identified by medical records data. seventy-three of the patients appeared in both studies. the ... | 1987 | 3807447 |
| ionic requirements for entry of shiga toxin from shigella dysenteriae 1 into cells. | the ionic requirements for entry of shiga toxin into cells were examined by measuring inhibition of protein synthesis after short-term incubations with toxin. the sensitivity of vero cells and hela cells to shiga toxin was strongly dependent on the divalent cation present. vero cells were most sensitive in the presence of cacl2 and srcl2, whereas hela cells were equally sensitive in the presence of mgcl2, srcl2, and cacl2. both cell lines were protected by bacl2, cocl2, and mncl2. inhibitors of ... | 1987 | 3542829 |
| identification of the carbohydrate receptor for shiga toxin produced by shigella dysenteriae type 1. | the binding of shiga toxin isolated from the bacterium shigella dysenteriae type 1 to a series of glycolipids and to cells or cell homogenates has been studied. bound toxin was detected using either 125i-labeled toxin or specific monoclonal antibody and 125i-labeled anti-antibody. overlay of toxin on thin-layer chromatograms with separated glycolipids and binding to glycolipids coated in microtiter wells established that the toxin specifically bound to gal alpha 1-4gal beta (galabiose) placed te ... | 1987 | 3543013 |
| actions of prostaglandins e2 and f2 alpha on release of 14c-labelled mucins from rat submandibular salivary acini in vitro. | mucin secretion was studied in vitro using well-characterized preparations of isolated acini. pge2 significantly (p less than 0.05) increased release of [14c]-glucosamine labelled mucins at the highest concentration tested (10(-5) m), but was ineffective at lower doses (10(-9)-10(-6) m). pgf2 alpha had no effect on mucin secretion over this concentration range. pge2 (10(-9)-10(-5) m) did not modify isoproterenol stimulated mucin secretion. the cyclooxygenase inhibitor indomethacin (10(-7)-10(-5) ... | 1987 | 3482153 |
| development of vaccines against shigellosis: memorandum from a who meeting. | endemic shigellosis is a worldwide problem, with a high morbidity rate in most developing countries; substantial mortality may also occur, especially with disease caused by shigella dysenteriae serotype 1. the limited efficacy of current measures to control this infection makes the development of vaccines for the prevention of shigellosis particularly important. this memorandum describes the clinical features of and immunity to shigellosis, summarizes the present status of efforts to develop sui ... | 1987 | 3495364 |
| dexamethasone pre-treatment is antipyretic toward polyinosinic: polycytidylic acid, lipopolysaccharide and interleukin 1/endogenous pyrogen. | the effect of intravenously injected dexamethasone on the febrile response of rabbits to polyinosinic: polycytidylic acid (poly i:c), lipopolysaccharide (lps) and interleukin 1/endogenous pyrogen (il1/e.p.) was studied. dexamethasone (1 mg/kg) attenuated the febrile response to poly i:c (5 micrograms/kg) but only if administered between 0.5 to 2 h before poly i:c. if it was given after poly i:c this resulted in a potentiation of the fever. antagonism of the febrile response to poly i:c by dexame ... | 1987 | 3495738 |
| idiopathic production of interleukin-1 in acquired immune deficiency syndrome. | we determined the capacity of peripheral blood monocytes from 19 patients with acquired immune deficiency syndrome (aids) or related conditions (1 with lymphadenopathy, 8 with aids-related complex, and 10 with aids) to produce intracellular and extracellular interleukin-1 (il-1) spontaneously and upon stimulation with bacterial endotoxin. all patients were anti-human t-cell lymphotropic virus type iii antibody positive. results were compared with those obtained with 10 normal controls of similar ... | 1987 | 3498739 |
| production and assay of ovine t cell growth factor by concanavalin a stimulated peripheral blood leukocytes. | conditions for the production and assay of ovine t cell growth factor (tcgf) activity were evaluated. peripheral blood leukocytes were stimulated with concanavalin a (con a) in the presence of 2% autologous serum or serum-free media. supernatants were harvested after 30 hr and concentrated for further characterization. a 28 hr proliferation assay with 2.5 x 10(4) 24 hr con a blasts per well was optimal for detection of tcgf. peak tcgf activity occurred with a 30-37 kd molecular weight fraction. ... | 1987 | 3499702 |
| [substantiation of using pancreatic galvanization in the treatment of acute pancreatitis]. | 1987 | 3502158 | |
| voluntary hyperventilation changes recruitment order of parasternal intercostal motor units. | the order of recruitment of single-motor units in parasternal intercostal muscles during inspiration was studied in normal human subjects during quiet breathing and voluntary hyperventilation. electromyograms were recorded from the second and third intercostal spaces by means of bipolar fine wire electrodes. flow at the mouth, volume, end-expired co2, and rib cage and abdominal anterior-posterior diameters were monitored. single-motor units were identified using criteria of amplitude and shape, ... | 1987 | 3558179 |
| [proliferative activity of experimental brain tumors]. | the method of autoradiography was used to study the parameters of the cell cycle and the intensity of proliferative processes in three transplantable rat brain tumors differing in the duration of the latent period and sensitivity to chemotherapy. the tumors were found to be similar in the duration of the cell cycle and its phases, the mean values of the label index and growth fraction, and were characterized by the irregularity of the proliferative processes within the tumor; the label index was ... | 1987 | 3564792 |
| cytotoxicity of shiga toxin for primary cultures of human colonic and ileal epithelial cells. | shiga toxin purified from shigella dysenteriae 1 was cytotoxic to cultured epithelial cells from human colon and ileum. the cytotoxicity, which affected only about 50% of treated cells, was neutralized by rabbit antiserum monospecific for shiga toxin and mediated by protein synthesis inhibition. | 1987 | 3570477 |
| hereditary hyperlipidemia in the rabbit due to overproduction of lipoproteins. i. biochemical studies. | an inherited metabolic disorder in a strain of new zealand white rabbits, characterized by marked hypercholesterolemia (394 +/- 100 mg/dl), with moderately elevated or normal triglyceride levels is described. low density lipoprotein (ldl), intermediate density lipoprotein (idl) and very low density lipoprotein (vldl) cholesterol levels were increased. vldl and idl, and to a lesser extent ldl, had increased free cholesterol and esterified cholesterol content, and triglyceride content was reduced. ... | 1987 | 3579720 |
| shigellosis in bangladesh. | 1987 | 3543150 | |
| convulsions in childhood shigellosis. clinical and laboratory features in 153 children. | we studied 153 children who experienced convulsions associated with shigellosis. the male-female ratio was 1.2:1.0. thirty-six children had a previous history of febrile convulsions, and 31 children had a family history of convulsive disorder. most of the children were 0.5 to 3 years of age, although 49 (32%) were older than 3 years of age and 20 (13.1%) were older than 5 years of age. all children were febrile; in 75% of the children, the temperature was over 39 degrees c. the majority of the c ... | 1987 | 3544808 |
| molecular properties of f9 embryoglycan recognized by a unique antibody in sera from patients with germ cell tumors. | human antibody against an embryoglycan present on a mouse teratocarcinoma cell line f9 was found in sera from 16 of 29 patients with embryonal carcinoma, yolk sac tumor, immature teratoma, and choriocarcinoma of gonadal and extragonadal origins by farr assay. in contrast, none of the sera from patients (77 cases) with dysgerminoma, seminoma, germinoma, and mature teratoma or from patients (118 cases) with nongerm cell types of ovarian tumors contained this antibody. the antigenic embryoglycan wa ... | 1987 | 3032420 |
| detection of aspartate kinase in rat liver and its activation by ca++ and calmodulin. | the enzyme aspartate kinase (ec 2.7.2.4) has been detected in rat liver (animal tissue) for the first time. this enzyme, like the aspartate kinase from bacteria and plants is inhibited by lysine and threonine. further, the activity of the enzyme is stimulated over two fold by ca++ and calmodulin and inhibited by egta, a ca++ chelator and trifluoperazine, an anti-calmodulin compound. | 1987 | 3034280 |
| detection of aspartate kinase in rat liver and its activation by ca++ and calmodulin. | the enzyme aspartate kinase (ec 2.7.2.4) has been detected in rat liver (animal tissue) for the first time. this enzyme, like the aspartate kinase from bacteria and plants is inhibited by lysine and threonine. further, the activity of the enzyme is stimulated over two fold by ca++ and calmodulin and inhibited by egta, a ca++ chelator and trifluoperazine, an anti-calmodulin compound. | 1987 | 3034280 |
| detection of leishmania parasites by dna in situ hybridization with non-radioactive probes. | in situ hybridization techniques develop rapidly into diagnostic tools of considerable value for detection of viruses and bacteria. here we report the application of this technique for the detection of leishmania parasites. biotin-labelled total promastigote dna was hybridized to cultured leishmania parasites and to blood and impression smears of infected mice. in promastigotes kinetoplasts were strongly stained, nuclei somewhat more diffuse. in amastigotes both nuclear and kinetoplast dna hybri ... | 1987 | 3035535 |
| [expressing plasmid vectors on the basis of escherichia coli beta-galactosidase gene fragments]. | with the use of synthetic dna fragments, a set of new plasmid vectors has been obtained. the vectors provided high level expression of peptides and small proteins in e. coli as fusions with fragments of beta-galactosidase of various length. these vectors were used to achieve expression of a synthetic gene for a functionally active fragment of bacteriorhodopsin. the yields of hybrid proteins consisting of beta-galactosidase and bacteriorhodopsin fragments were in the range of 5-30% from the total ... | 1987 | 3036168 |
| localization of stx, a determinant essential for high-level production of shiga toxin by shigella dysenteriae serotype 1, near pyrf and generation of stx transposon mutants. | hfr strains of shigella dysenteriae serotype 1 were constructed by transient integration of an rp4 plasmid derivative carrying transposon tn501 into the shigella chromosome through tn501-mediated cointegration. the hfr strains were mated with escherichia coli k-12 recipients carrying various auxotrophic markers, and e. coli recombinants which had received prototrophic shigella genes were selected. some of the e. coli transconjugants produced high levels of a cytotoxin which was neutralized by bo ... | 1987 | 3040592 |
| effect of b cell stimulatory factor-1 (interleukin 4) on fc epsilon and fc gamma receptor expression on murine b lymphocytes and b cell lines. | culture of murine splenic b cells with interleukin 4 (il-4) caused the up-regulation of the lymphocyte fc receptor for immunoglobulin e (ige) (fc epsilon r) over a similar dose range as required for ia up-regulation. however, the expression level of the fc receptor for immunoglobulin g (fc gamma r) did not increase, rather il-4 caused a slight but consistent decrease in the fc gamma r level on the b cells. fc epsilon r+ b hybridoma cells also responded to il-4 by exhibiting increased fc epsilon ... | 1987 | 2958544 |
| an outbreak of dysentery due to shigella dysenteriae type 1 in rangoon, burma. | 1987 | 2963061 | |
| redistribution of nuclear ribonucleoprotein antigens during herpes simplex virus infection. | infection of human epidermoid carcinoma no. 2 cells with herpes simplex virus type 1 (hsv-1) leads to a reorganization of antigens associated with both the small and heterogeneous nuclear ribonucleoprotein complexes (snrnp and hnrnp). the hnrnp core protein antigens remain associated with the host chromatin, which appears to collapse into internal aggregates and along the nuclear envelope. more striking is the formation of prominent clusters of snrnp antigens (both general and u1 snrnp specific) ... | 1987 | 2824525 |
| limb specific connections of the cat magnocellular red nucleus. | afferent and efferent connections of the limb specific divisions of the cat magnocellular red nucleus (rnm) were traced using the bidirectional transport of wheatgerm agglutinin-horseradish peroxidase complex (wga-hrp). injection sites within forelimb or hindlimb rnm regions were identified by microelectrode recording and confirmed by the position of labeled rubrospinal terminals. additional injections into structures that project to, or receive input from, rnm confirmed the somatotopic organiza ... | 1987 | 2826551 |
| monoclonal antibodies specific for shigella flexneri lipopolysaccharides: clones binding to type iv, v, and vi antigens, group 3,4 antigen, and an epitope common to all shigella flexneri and shigella dysenteriae type 1 stains. | monoclonal antibodies reactive with shigella flexneri o antigens were generated in both mouse and rat systems. antibody-producing hybridomas were screened in an enzyme-linked immunosorbent assay using chemically defined lipopolysaccharides as antigens, and the epitope specificities were determined with a panel of lipopolysaccharides and synthetic o-antigen-specific glycoconjugates as antigens. to verify the specificity seen in the enzyme-linked immunosorbent assay, the antibodies were used in ag ... | 1987 | 2437036 |
| [structure of the o-specific polysaccharide chain of shigella dysenteriae type 7 lipopolysaccharide]. | the structure of the o-specific polysaccharide chain of the shigella dysenteriae type 7 lipopolysaccharide has been established mainly by 13c nmr analysis of the intact and modified (acetylated and de-o-acetylated) polymers, as well as of products of its solvolysis with anhydrous hydrogen fluoride. the polysaccharide contains two unusual sugar derivatives. n-acetyl-d-galactosaminuronamide and 4-(n-acetylglycyl)amido-4,6-dideoxy-d-glucose (galnacan and qui4n----glyac, respectively) and is built u ... | 1987 | 2445353 |
| the effects of the protein synthesis inhibitor anisomycin on the febrile responses to intracerebroventricular injections of bacterial pyrogen, arachidonic acid and prostaglandin e2. | 1. anisomycin (15 mg/kg) was administered s.c. to cats at ambient temperatures of 5 degrees c, 20 degrees c and 38 degrees c. it produced biphasic effects on body temperature at 5 degrees c and 20 degrees c, an initial fall in temperature followed by a rise in body temperature, and a rise in body temperature of long latency at 38 degrees c. 2. anisomycin (15 mg/kg) attenuated the hyperthermic responses to centrally injected pge2 (1 microgram) at all ambient temperatures studied and also complete ... | 1987 | 2446153 |
| comparative effects of adriamycin and dna-non-binding analogues on dna, rna, and protein synthesis in vitro. | drug-dna binding is claimed to be the basis by which the antitumor antibiotic adriamycin (doxorubicin) inhibits dna and rna synthesis in vitro. however, in preliminary studies the dna-non-binding adriamycin analogue n-trifluoroacetyladriamycin-14-valerate (ad 32) showed somewhat greater inhibition of dna and rna synthesis than adriamycin under identical conditions. the kinetics of macromolecule synthesis inhibition induced by adriamycin and ad 32, and the two principal dna-non-binding metabolite ... | 1987 | 2446792 |
| effects of substance p, neurokinin a and calcitonin gene-related peptide in human skin and their involvement in sensory nerve-mediated responses. | the effects evoked by intradermal injections of substance p (sp), neurokinin a (nka) or calcitonin gene-related peptide (cgrp) were studied in 51 non-atopic subjects. sp and nka produced flare and weal, and cgrp produced an indurated erythema. the reactions to sp were strong, the flare being maximal 3-5 min after injection and the weal after 10-15 min. nka evoked a much weaker flare and a slightly weaker weal than did sp. cgrp produced a prominent long-lasting, indurated erythema with pseudopod ... | 1987 | 2446892 |
| structural homology of human complement component c8 gamma and plasma protein hc: identity of the cysteine bond pattern. | anti-c8 alpha-gamma specific antibodies were used to isolate cdna clones from a human liver expression library. antibodies affinity-purified on the expressed hybrid protein of one clone bound exclusively to the gamma-chain of reduced c8 alpha-gamma. this clone, as well as a second full length cdna clone obtained by hybridization screening, were sequenced and the complete primary structure for c8 gamma was established. cyanogen bromide cleavage of c8 alpha-gamma released a 12 kda carboxy-terminal ... | 1987 | 2447883 |
| media for isolating shigella. | 1987 | 2881104 | |
| comparison of the effects of fe2+ and cu2+ on prostaglandin synthesis in rabbit kidney medulla slices. | the effects of fe2+ and cu2+ on the generation of medullary prostaglandins e2 and f2 alpha have been compared. fe2+ markedly promoted the lipid peroxidation of rabbit kidney medulla slices. the lipid peroxidation induced by fe2+ inhibited both prostaglandin e2 and prostaglandin f2 alpha formation to a similar extent. while cu2+ produced only a small increase in lipid peroxidation, it had a powerful inhibitory effect on prostaglandin e2 formation. simultaneously, prostaglandin f2 alpha production ... | 1987 | 2883291 |
| plasmid-mediated resistance to nalidixic acid in shigella dysenteriae type 1. | in an epidemic of shigellosis in southern bangladesh the causal organism, shigella dysenteriae type 1, was resistant to nalidixic acid as well as to co-trimoxazole (trimethoprimsulphamethoxazole) and ampicillin. the genes coding for resistance to nalidixic acid, but not those coding for resistance to co-trimoxazole or ampicillin, are located on a conjugative 20 megadalton plasmid. this epidemic is of particular importance because of the resistance to nalidixic acid, an antibiotic to which shigel ... | 1987 | 2887725 |
| enhancement of contractile responses to partial alpha-adrenoceptor agonists during warming in rat aorta. | we examined the effects of warming on the contractile responses to full and partial alpha-adrenoceptor agonists in rat aorta. the contractions elicited by norepinephrine and methoxamine were not affected during warming (40 degrees c, 42 degrees c), whereas those induced by clonidine and st 587 were significantly enhanced. kcl-induced contractions of rat aorta were not affected by warming. the dissociation constants of clonidine and st 587 at 40 degrees c were not different from those at 37 degre ... | 1987 | 2895427 |
| clinical and biochemical significance of toxin production by aeromonas hydrophila. | production of cytotoxin and enterotoxin by aeromonas strains obtained from stools of 50 children in mexico and texas and from blood of 9 children with sepsis was determined. results were correlated with clinical features of infected children as well as with biochemical traits of aeromonas strains. cytotoxin was produced by 40 of 42 aeromonas strains (95%) isolated from stools of children with diarrhea, by all 8 isolates from stools of well children, and by all 9 isolates from children with sepsi ... | 1987 | 3584426 |
| cardiac-specific troponin-i radioimmunoassay in the diagnosis of acute myocardial infarction. | the cardiac isotype of the myofibrillar contractile protein, troponin-i, is located specifically in the mammalian heart. a sensitive radioimmunoassay has been developed to detect human and nonhuman primate cardiac troponin-i in serum down to 10 ng/ml. immunochemical cross reactivity with skeletal troponin-i was only 2% and was species nonspecific. normal patient levels of cardiac troponin-i are about 10 ng/ml. in patients with acute myocardial infarction (n = 32), serum cardiac troponin-i was el ... | 1987 | 3591601 |
| tubal microsurgery. ii. experimental use. | tubal microsurgery is a valuable tool to study tubal reproductive physiology and various infertility problems. microsurgical tubal resection reanastomoses of the rabbit fallopian tube and their impact on fertility are reviewed. data obtained from experimental work on the function of cilia and muscle activity in tubal transport are discussed. | 1987 | 3596349 |
| [combined effects of fentanyl and diazepam on hemodynamics and myocardial blood flow in dogs with normal and ischemic heart]. | 1987 | 3613053 | |
| pentapeptide nuclear localization signal in adenovirus e1a. | the adenovirus e1a gene products are nuclear proteins important in transcriptional control of viral functions during infection. by producing normal e1a proteins and derivatives of e1a in bacteria and microinjecting these proteins into cultured cells, we were able to examine their ability to localize to the nucleus. we showed that a short peptide sequence at the carboxyl terminus of e1a is necessary for the rapid (30-min) nuclear localization of that protein. additionally, we showed that just the ... | 1987 | 3614197 |
| thermally induced disulfide bond exchanges in human ige. | the thermally induced changes in human ige was investigated using sodium dodecyl sulfate-polyacrylamide gel electrophoresis. when the ige (1 mg/ml) was heated at 56 degrees c for several hours in the absence of sodium dodecyl sulfate, it gave aggregated forms that could be reduced completely to heavy and light chains with dithiothreitol. on the other hand, in the presence of sodium dodecyl sulfate (0.1%), the ige was changed by heating to five components with small mol. wts dependent on temperat ... | 1987 | 3614214 |
| myocardial dysfunction in sepsis. | a synthesis of the postulated sequence of events for development of the inappropriate response of the myocardium to a demand for increased cardiac index is schematically represented in fig. 10. in sepsis, bacteremia and/or the release of endotoxin activate the macrophages which release a spectrum of mediators. some of these mediators (and possibly also endotoxin itself) have a negative influence on myocardial contractile function either directly and/or through altering cellular calcium flux. thi ... | 1987 | 3615452 |
| myocardial dysfunction in sepsis. | a synthesis of the postulated sequence of events for development of the inappropriate response of the myocardium to a demand for increased cardiac index is schematically represented in fig. 10. in sepsis, bacteremia and/or the release of endotoxin activate the macrophages which release a spectrum of mediators. some of these mediators (and possibly also endotoxin itself) have a negative influence on myocardial contractile function either directly and/or through altering cellular calcium flux. thi ... | 1987 | 3615452 |
| altered shape and size of red blood cells in obese hyperglycaemic mice. | red blood cells (rbcs) from hyperglycaemic ob/ob-mice, normoglycaemic controls, and a healthy man were sucked into a narrow capillary, photographed and measured. mouse rbcs had a smaller diameter than human ones. although of normal diameter, the ob/ob-mouse rbcs exhibited increased area and volume, and more frequently than control rbcs had a minimum cylindrical diameter greater that 3 micron. cross-sectional profiles with minimum bending resistance were computed for rbcs of mean area and volume. ... | 1987 | 3630732 |
| isoperiodic bursting by magnocellular neuroendocrine cells in the rat hypothalamic slice. | 1. recruitment of magnocellular neuroendocrine cells (m.n.c.s) to a repetitive burst pattern (phasic firing) is associated with increased vasopressin secretion from neurohypophysial terminals in the intact animal. based on invertebrate studies, bursts of action potentials can arise in two distinct ways: as an intrinsic property of the recorded cell or as an emergent property of synaptic interactions. 2. the majority of phasic m.n.c.s in the hypothalamic slice preparation display an endogenous pa ... | 1987 | 3656153 |
| photoperiodic modification of negative and positive feedback effects of oestradiol on lh secretion in ovariectomized goats. | ovariectomized shiba goats carrying an oestradiol implant (4-10 pg/ml) were kept under a short-day light regimen (10l:14d; group 1, n = 4) or a long-day regimen (16l:8d; group 2, n = 4). plasma lh concentrations were lower (p less than 0.05) in group 2 than in group 1 between days 40 and 200, suggesting an enhanced negative feedback effect of oestradiol on lh secretion under a long-day regimen. on days 30, 60, 100, 149 and 279, an lh surge was induced by i.v. infusion of oestradiol for 48 h; the ... | 1987 | 3656284 |
| effect of different fractions of dialyzable leukocyte extract--transfer factor--on the chemiluminescence of human phagocytes. | the chemiluminescence (cl) inducing effect of the fractions of dialyzable leukocyte extract (dle)--transfer factor--from tonsil leukocytes was tested on the phagocytes of human whole blood. the fractionation of dle by sephadex g-25 results in three main fractions: i, ii, iii. we found only fraction ii having a direct cl inducing effect on the non-stimulated cells. fraction ii increased further the cl of phagocytes which were stimulated by zymosan (mannozym). fractions i and iii were ineffective. ... | 1987 | 3661353 |
| the mode of action of shiga toxin on peptide elongation of eukaryotic protein synthesis. | the effect of shiga toxin, from shigella dysenteriae 1, on the component reactions of peptide elongation were investigated. enzymic binding of [3h]phenylalanine-trna to reticulocyte ribosomes was inhibited by 50% at 7 nm toxin. elongation factor 1 (eef-1)-dependent gtpase activity was also inhibited. both reactions were not restored by addition of excess eef-1 protein. in contrast, toxin concentrations of 200 nm were required to inhibit by 50% the elongation factor 2 (eef-2)-dependent translocat ... | 1987 | 3663122 |
| leukemoid reaction in shigella dysenteriae type 1 infection. | 1987 | 3666850 | |
| intra-right-atrial balloon pumping (irabp) during a fontan procedure. | 1987 | 3676005 | |
| [change in tissue glycogen reserves in tumor bearers as a reflection of a hypoglycemic stress syndrome]. | glycogen content in the brain, liver and skeletal muscles of rats bearing ascite zajdela hepatoma (azh) and solid 27 hepatoma (27-h) has been studied. serum glucose levels directly correlated with liver glycogen reserves. in the terminal stage of tumor growth depletion of liver glycogen was observed, while the stores of muscle glycogen did not diminish. within 1-4 days (azh) and 15-30 days (27-h) after implantation the stores even exceeded those of control healthy rats. in the terminal stage, in ... | 1987 | 3689968 |
| enzyme-linked immunosorbent assay to detect shiga toxin of shigella dysenteriae and related toxins. | a sandwich enzyme-linked immunosorbent assay (elisa) was developed for detection of shiga toxin. four species of shigella, escherichia coli, and vibro parahaemolyticus were tested for production of shiga or shiga-like toxin by elisa and vero cell bioassay. in the elisa, most strains of s. dysenteriae and some strains of e. coli isolated from traveler's diarrhea were positive. these elisa-positive strains were positive by vero cell bioassay without exception. some e. coli strains and most v. para ... | 1987 | 3539985 |
| ascending urinary tract infections in rats induced by staphylococcus saprophyticus and proteus mirabilis. | ascending pyelonephritis was induced by staphylococcus saprophyticus and proteus mirabilis both by inoculating the organisms separately and in combination into rat bladders. bacterial cultures of tissue homogenates showed that pyelonephritis by both bacteria occurred significantly more often in rats where the two organisms were instilled concomitantly, suggesting a synergistic virulence between the two species. the antibody response to the different organisms was the same either the bacteria wer ... | 1987 | 3326399 |
| aspergillosis of the brain: report of an autopsy proven case. | 1987 | 3327911 | |
| differential clinical features and stool findings in shigellosis and amoebic dysentery. | to obtain information that could assist the clinician to differentiate between shigellosis and amoebic dysentery, we compared clinical features and stool findings in 58 adult male patients in bangladesh. mean values indicated that patients with invasive amoebiasis were older and had a longer prehospital illness, a lower body weight, less frequent fever, a lower haematocrit and a higher white blood cell count than patients with shigellosis. the mean number of faecal leucocytes per mm3 was signifi ... | 1987 | 3328339 |
| [antipuretic, antimicrobic action of gegen qinlian tang]. | 1987 | 3328655 | |
| [trial use of embryonal and early-fetal thymus extracts in the treatment of non-healing skin defects. ii. crural ulcers in humans]. | 1987 | 3329747 | |
| xylose lysine desoxycholate agar for recovering shigella dysenteriae 1 and shigella flexneri from faeces. | 1987 | 3330107 | |
| imipenem/cilastatin for pediatric infections in hospitalized patients. | one hundred and four children who were hospitalized for documented or suspected non-cns bacterial infections (56 males/48 females, 22 days to 15 years old) were treated with intravenous imipenem/cilastatin for 9.4 days (range 3 to 28 days). children up to three years of age received 100 mg/kg/day and older children 60 mg/kg/day, administered in four divided doses. bacterial pathogens were isolated before therapy in 85%. diagnoses in the 74 evaluable patients included bronchopneumonia with or wit ... | 1987 | 3331043 |
| increase in multiresistance of shigella dysenteriae type 1 strain in rwanda. | 1987 | 3333152 | |
| clinical features, including haemolytic-uraemic syndrome, in shigella dysenteriae type 1 infection in children of rangoon. | 1987 | 3333769 | |
| [non-tuberculous infections of the spine]. | non tuberculous spondylodiscitis of the rachis is an uncommon entity that affects boys and male adults with greater frequency. the zone with higher incidence of affection is the lumbar region. usually the causal germ travels through the hematogenous via from an extrarachidial infectious area. clinical manifestations begin with an acute segmentary rachialgia and paravertebral muscular contracture while presenting fever. in special cases of little boys or when having radiated pain, the presenting ... | 1987 | 3333891 |
| [non-tuberculous infections of the spine]. | non tuberculous spondylodiscitis of the rachis is an uncommon entity that affects boys and male adults with greater frequency. the zone with higher incidence of affection is the lumbar region. usually the causal germ travels through the hematogenous via from an extrarachidial infectious area. clinical manifestations begin with an acute segmentary rachialgia and paravertebral muscular contracture while presenting fever. in special cases of little boys or when having radiated pain, the presenting ... | 1987 | 3333891 |
| epidemiological aspects of plasmid profiles in shigella dysenteriae type 1 strains isolated from burma & india. | 1987 | 2967798 | |
| new aspects in the pharmacology of kindling implications for mechanism of of action in kindling. | kindling is a long-lasting, transsynaptic, pathway-specific plastic change in brain function. it has been proposed as a model of neural plasticity, learning and memory, as well as a model of epilepsy. to elucidate the action of substances characterized by their ability to improve learning and memory and to have an activatory, protective and function restoring effect on nerve cells in distress, the effects of nootropic drugs and of antioxidative acting substances on the development of kindling an ... | 1987 | 3147457 |
| disseminated intravascular coagulation in post-dysenteric haemolytic uraemic syndrome. | coagulation studies were carried out in 14 children with haemolytic uraemic syndrome that followed acute dysentery. stool cultures showed shigella dysenteriae in 3 cases and were sterile in the remainder. prolongation of the prothrombin time, activated partial thromboplastin time and thrombin time and raised levels of fibrinogen degradation products were found in 12 cases, indicating the presence of disseminated intravascular coagulation. renal histologic examination showed cortical necrosis in ... | 1987 | 3425309 |
| glutathione metabolism in isolated rat hepatocytes: acinar heterogeneity of detoxifying enzymes and effects of ethanol. | periportal and perivenous hepatocytes were isolated by the digitonin-collagenase perfusion technique. the activity of the cytosolic glutathione s-transferase was higher in perivenous cells, but the cytosolic glutathione reductase and the microsomal glutathione s-transferase activities were evenly distributed. in contrast, both the se-dependent and the microsomal se-independent glutathione peroxidase activity and the glucose-6-phosphate dehydrogenase activity was much lower in perivenous hepatocy ... | 1987 | 3426686 |
| serological investigations on the cause of diarrhoea on the cape verde islands. | in the serological tests 45.9% of all samples reacted positive against rota virus. 20.8% of samples revealed entamoeba histolytica positive sera, 25% shigella flexneri positive sera, 12.3% shigella sonnei and 13% shigella dysenteriae positive sera. campylobacter jejuni antibodies were found in 19% of samples, whereas 6.3% of sera reacted positive against yersinia enterocolitica type 3 and 4.8% against type 9. | 1987 | 3443746 |
| serological investigations for the cause of diarrhoea among patients and personnel in the minna and abeokuta hospitals/nigeria. | 188 blood samples were investigated for antibodies against bacteria causing diarrhoea in two hospitals in minna and abeokuta in nigeria. antibodies were found against entamoeba histolytica, yersinia enterocolitica, campylobacter jejuni, salmonella typhi, salmonella paratyphi c, shigella dysenteriae, shigella sonnei, shigella boydii, shigella flexneri and rotavirus. | 1987 | 3443752 |
| moniliella suaveolens var. nigra. | 1987 | 3444445 | |
| differences between saccharomyces cerevisiae and bacillus subtilis in secretion of human lysozyme. | saccharomyces cerevisiae secreted human lysozyme in the medium as an active form when the signal peptides of chicken lysozyme and a chicken lysozyme-aspergillus awamori glucoamylase hybrid were used, whereas it did not synthesize any human lysozyme protein by using the signal peptide of a. awamori glucoamylase. the secreted lysozyme was easily purified and crystallized. on the other hand, bacillus subtilis secreted an inactive human lysozyme, which seemed to have incorrect disulfide bonds, with ... | 1987 | 3109419 |
| differences between saccharomyces cerevisiae and bacillus subtilis in secretion of human lysozyme. | saccharomyces cerevisiae secreted human lysozyme in the medium as an active form when the signal peptides of chicken lysozyme and a chicken lysozyme-aspergillus awamori glucoamylase hybrid were used, whereas it did not synthesize any human lysozyme protein by using the signal peptide of a. awamori glucoamylase. the secreted lysozyme was easily purified and crystallized. on the other hand, bacillus subtilis secreted an inactive human lysozyme, which seemed to have incorrect disulfide bonds, with ... | 1987 | 3109419 |
| alternative pathway of complement activation by stimulated t lymphocytes. ii. elevation of cytotoxic potential against complement receptor-carrying cell lines. | exposure of lectin-stimulated (concanavalin a, phytohemagglutinin and pokeweed mitogen) blood lymphocytes to human serum or to purified c3 increased their cytotoxic capacity towards complement receptor positive targets such as raji and daudi cells. the lysis of complement receptor-negative lymphoblastoid cell lines was not influenced. the lytic capacity of lymphocytes exposed to 12-o-tetradecanoylphorbol 13-acetate was not elevated by human serum. lectin-stimulated lymphocytes were previously sh ... | 1987 | 3111863 |
| [local epidemic of neonatal listeriosis in upper austria--report of 20 cases]. | in an 8 month period, 20 cases of listeriosis among neonates were seen in the federal district of upper austria. the majority of mothers reported influenza-like symptoms at the end of pregnancy. 19 cases were early-onset-infections, 6 infants developed meningitis. serotype 1/2a was isolated in 7 cases. all were of the same phage type. 15 neonates were successfully treated with aminopenicillin or penicillin. treatment with cephalosporin was ineffective. 4 mainly premature infants died, 1 was stil ... | 1987 | 3119914 |
| evidence that stimulation of growth hormone release by epinephrine and vasoactive intestinal peptide is based on cell-to-cell communication in the pituitary. | epinephrine (epi) evoked a strong concentration-dependent (1-1000 nm) rise of gh release from perifused rat anterior pituitary cells cultured as aggregates in a serum-free defined culture medium. dexamethasone (dex), added to the culture medium, enhanced the secretory response to epi. aggregates of pituitary cells separated by gradient sedimentation at unit gravity widely differed in responsiveness to epi, provided dex was added to the culture medium. the poorest response was seen in aggregates ... | 1987 | 3023029 |
| evidence that stimulation of growth hormone release by epinephrine and vasoactive intestinal peptide is based on cell-to-cell communication in the pituitary. | epinephrine (epi) evoked a strong concentration-dependent (1-1000 nm) rise of gh release from perifused rat anterior pituitary cells cultured as aggregates in a serum-free defined culture medium. dexamethasone (dex), added to the culture medium, enhanced the secretory response to epi. aggregates of pituitary cells separated by gradient sedimentation at unit gravity widely differed in responsiveness to epi, provided dex was added to the culture medium. the poorest response was seen in aggregates ... | 1987 | 3023029 |
| effects of marine mammal parasites on human health. | 1987 | 3294653 | |
| an accessory protein identical to mouse egasyn is complexed with rat microsomal beta-glucuronidase and is identical to rat esterase-3. | we report biochemical, immunological, and genetic studies which demonstrate that an accessory protein with the essential features of mouse egasyn is complexed with and stabilizes a portion of beta-glucuronidase in microsomes of rat liver. the accessory protein exists as a complex with beta-glucuronidase since it coprecipitates with beta-glucuronidase after treatment of extracts with a specific beta-glucuronidase antibody. the two proteins are associated by noncovalent bonds since they are easily ... | 1987 | 3294829 |