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effect of psychosis on suicide risk in 1,593 patients with unipolar and bipolar affective disorders.the authors report suicide risk among 1,593 patients with major depression or bipolar disorder, 443 (27.8%) of whom were psychotic (260 bipolar and 183 unipolar). the subjects were followed for 0-14 years, and their suicide experience was compared with that of the state population. eight (19.5%) of the 41 suicide victims were from the psychotic group. the psychotic and nonpsychotic subjects in each diagnostic group had similar risks for suicide. a higher risk for suicide was not found in the bip ...20123381930
[vesicoscrotal hernia]. 20123382251
artificial insemination with cryopreserved donor semen: a decade of experience.ten years' experience of artificial insemination with cryopreserved donor semen for 1023 courses in 783 women resulting in 572 pregnancies is reported. a simple approach with multiple inseminations timed on the basis of cycle length, temperature charts, mucus symptoms and signs was used. the life table pregnancy rate was 61% after 12 cycles of treatment and 75% after 24 cycles. women had a significantly higher rate of pregnancy in second and subsequent courses of treatment, and the pregnancy rat ...20123382608
isolation of yeasts from male contacts of women with vaginal candidosis. 20123384434
risk factors for infantile recurrent otitis media: atopy but not type of feeding.we followed 183 infants from birth to 2.3 yr of age. of these infants 28 had recurrent otitis media (rom), defined as five or more separate episodes of otitis media (om) during the first 2 yr of life or four such episodes during their 2nd yr. the om presented during their 1st yr (early-onset rom) in 12 infants and during their 2nd yr (2nd yr rom) in 16. eighty infants had no om and served as a comparison group. regarding type of feeding, the infants with early-onset rom did not differ from their ...20123387173
community psychiatry--a changing locus of rejection? 20123393415
examination of the role of cigarette smoke in lung carcinogenesis using multistage models.the widely used multistage model of armitage and doll is fit to the british physician lung cancer data of doll and hill under the assumption that cigarette smoke induces the initial and penultimate changes. it is shown that the best fit of this model in continuing smokers gives predictions not in accordance with incidence in ex-smokers and dose-response. a better global fit can be obtained by increasing the number of stages, but this de-emphasizes initiation and is inconsistent with the rise of ...20123398067
thrombocytosis elevates serum potassium.spurious elevation of the serum potassium can be seen if the platelet count exceeds 1,000 x 10(9)/l in patients with myeloproliferative disease. to see if serum potassium is increased at more modest elevations of the platelet count we studied these parameters in 283 controls and 161 patients with reactive thrombocytosis. the incidence of hyperkalemia was 34% in patients with over 500 x 10(9) platelets/l compared with 9% if the platelet count was below 250 x 10(9)/l. over this range there was a s ...20123400632
serum myoglobin levels in patients with ischemic myocardial insult.serum myoglobin levels were studied in 178 consecutive patients admitted for chest pain due to ischemic cardiac injury. serum myoglobin level was compared with the clinical condition, electrocardiographic changes, and serum creatine kinase levels. elevated serum myoglobin concentration was present in all patients with acute myocardial infarction, as defined by world health organization, geneva, criteria, and, in addition, in about 50% of patients with so-called acute coronary insufficiency. on t ...20123401097
lipectomy influences white adipose tissue lipoprotein lipase activity and plasma triglyceride levels in ground squirrels.golden-mantled ground squirrels undergo marked fattening and fat depletion during the prehibernatory and hibernatory phases, respectively, of their annual body weight cycle. fat regulation was studied by surgical removal (lipectomy) of most of the inguinal-subcutaneous, retroperitoneal, and parametrial fat depots from female squirrels during the weight-gain phase of the annual cycle. seven weeks after surgery, body weights of lipectomized (lipx) and sham-lipx squirrels were equivalent, although ...20123405095
melanoma. 20123406162
a direct microassay for serum retinol (vitamin a alcohol) by using size-exclusion high-pressure liquid chromatography with fluorescence detection.serum retinol (bound to plasma retinol-binding protein, rbp) can be determined by direct injection of as little as 20 microliter of serum or plasma by using size-exclusion high-pressure liquid chromatography (se-hplc) with fluorescence detection. toyo soda tsk g-3000sw columns (0.75 x 7.5-cm guard column plus 0.75 x 30-cm analytical column) were eluted with 0.2 m nacl/0.01 m phosphate buffer (ph 6.8) at 1 ml/min, with detection at 280 nm for protein elution. fluorescence of the retinol-rbp compl ...19883407933
responses and behaviour of patients with borderline personality disorder during semi-structured interviews.the researchers investigated the behaviour of the borderline personality disorder (bpd) patient, based on observations during structured interviews, to test the hypothesis that these patients are frequently more hostile, aggressive, demanding and manipulative in an interview situation, as has been reported in the literature. these patients were compared to a similar group which had been identified as having bpd traits. the findings suggest that the bpd patients respond with more helplessness and ...20123409152
alpha-interferon therapy for japanese patients with hairy cell leukemia. 20123412025
[analysis of content uniformity of dosage units of chinese patent medicines]. 20123416384
patterns of lactate dehydrogenase isoenzymes in serum of patients with acute pulmonary edema.total lactate dehydrogenase (ld; ec 1.1.1.27) activity in serum and proportions of ld isoenzymes were quantified on admission and discharge in 170 selected (from 240) patients with acute pulmonary edema (ape). the patients were divided into group a, 75 patients with normal ld values (less than 225 u/l); and groups b-e, with increased ld activity in serum: group b, 40 patients with increase in the proportion of ld-3 (greater than 38%); group c, 12 patients with increased ld-5; group d, 36 patient ...20123416439
c-myc expression and transformed phenotypes in hybrid clones between mouse plasmacytoma s194 cells and normal spleen cells or fibroblasts.expression of the rearranged c-myc oncogene and transformed phenotypes was investigated in 2 different types of somatic cell hybrid clones between a balb/c mouse plasmacytoma line (s194) and normal allogeneic spleen cells or fibroblasts. in the parental s194 cells, one allele of the c-myc was rearranged and its 5'-flanking region was partially deleted by recombination with the immunoglobulin c alpha gene. due to this recombination, s194 cells expressed approximately 20-fold higher than normal sp ...19883417371
genetic characterization of leishmania isolates at 37 enzyme loci. 19883417374
knobbed spermatozoa in two normande bulls.two unrelated yearling normande bulls in a bull stud had 26 and 18% knobbed spermatozoa as well as other major sperm abnormalities. one of the bulls was eliminated from the bull stud because of poor semen quality and growth performance. the other bull was maintained for additional semen evaluation, during which time the mean percentage of major sperm abnormalities decreased, indicating amelioration of a transient testicular degeneration.19883417539
dorks, nerds, and bad people. 20123417627
clinical trial of low-fat, high-carbohydrate diet in subjects with mammographic dysplasia: report of early outcomes.despite evidence that dietary fat intake may influence breast cancer risk, there is little information about the effects of dietary fat on the human breast. we have studied the effects of dietary fat on the breast by examining the influence of dietary fat reduction on mammographic dysplasia (nodular or sheetlike areas of radiological density). subjects with mammographic dysplasia were randomly allocated to a control group, in which they received advice about maintaining a balanced diet (36% of c ...19883418730
quality assurance. 20123419994
pressure sores: a biochemical test for early detection of tissue damage.this study was undertaken to seek biochemical indicators in blood associated with the onset of early tissue damage which may progress to the formation of a pressure sore. changes in serum creatinine phosphokinase (cpk), inorganic phosphate, and lactate dehydrogenase in systemic blood of pigs were investigated before, during, and after local indentation. pressures of 540mmhg and 700mmhg were applied for six hours on both sides of the scapula and backs of five anesthetized animals. two hours after ...19883421821
kawasaki disease: circulating immune complexes monitored during the disease. 20123423075
femoral component loosening in hip arthroplasty. cadaver study of subsidence and hoop strain.to aid in understanding loosening following cemented total hip arthroplasty, we conducted a cadaver study of the proximal femur with implanted cobalt-chromium and titanium femoral components of recent design, loaded through the head of the prosthesis. stem subsidence and strain in the proximal femur were measured. after proximal support of the implant collar was removed, we found that cobalt-chromium implants had a greater tendency to subside than titanium implants. subsidence of a femoral compo ...20123425274
disseminated intravascular coagulation in post-dysenteric haemolytic uraemic syndrome.coagulation studies were carried out in 14 children with haemolytic uraemic syndrome that followed acute dysentery. stool cultures showed shigella dysenteriae in 3 cases and were sterile in the remainder. prolongation of the prothrombin time, activated partial thromboplastin time and thrombin time and raised levels of fibrinogen degradation products were found in 12 cases, indicating the presence of disseminated intravascular coagulation. renal histologic examination showed cortical necrosis in ...19873425309
the homeless mentally ill. 20123426247
glutathione metabolism in isolated rat hepatocytes: acinar heterogeneity of detoxifying enzymes and effects of ethanol.periportal and perivenous hepatocytes were isolated by the digitonin-collagenase perfusion technique. the activity of the cytosolic glutathione s-transferase was higher in perivenous cells, but the cytosolic glutathione reductase and the microsomal glutathione s-transferase activities were evenly distributed. in contrast, both the se-dependent and the microsomal se-independent glutathione peroxidase activity and the glucose-6-phosphate dehydrogenase activity was much lower in perivenous hepatocy ...19873426686
the health-care business--a search for a path through the jungle. 20123434643
surgical reconstruction of the upper extremity in cerebral palsy. 19953437126
the halo orthosis in the treatment of cervical spine injury. 19963437145
one year surveillance of sporadic hepatitis a in children at chandigarh. 20123443478
serological investigations on the cause of diarrhoea on the cape verde islands.in the serological tests 45.9% of all samples reacted positive against rota virus. 20.8% of samples revealed entamoeba histolytica positive sera, 25% shigella flexneri positive sera, 12.3% shigella sonnei and 13% shigella dysenteriae positive sera. campylobacter jejuni antibodies were found in 19% of samples, whereas 6.3% of sera reacted positive against yersinia enterocolitica type 3 and 4.8% against type 9.19873443746
serological investigations for the cause of diarrhoea among patients and personnel in the minna and abeokuta hospitals/nigeria.188 blood samples were investigated for antibodies against bacteria causing diarrhoea in two hospitals in minna and abeokuta in nigeria. antibodies were found against entamoeba histolytica, yersinia enterocolitica, campylobacter jejuni, salmonella typhi, salmonella paratyphi c, shigella dysenteriae, shigella sonnei, shigella boydii, shigella flexneri and rotavirus.19873443752
moniliella suaveolens var. nigra. 19873444445
[electrocardiographic and angiographic follow-up of patients with hypertrophic cardiomyopathy].electrocardiographic follow-up was conducted for 17 patients with hypertrophic cardiomyopathy including six cases who received left ventriculographic follow-up. 1. serial ecg changes were as follows: 1) in seven patients negativity of the t wave appeared or increased concomitantly with increased voltage of sv1 + rv5 (a-1 group). 2) in four patients, negativity of the t wave decreased or disappeared with the decreased voltage of sv1 + rv5 (a-2 group). 3) in six patients, there were insignificant ...20123448167
osteogenic sarcoma and soft tissue myxoma in a patient with fibrous dysplasia and hemoglobins jbaltimore and s.a 41-year-old man with recognized polyostotic fibrous dysplasia since late childhood developed fibroblastic osteogenic sarcoma in the left tibia. four months after the initial diagnosis, an intramuscular myxoma was discovered in the left thigh. twenty years previously he had been found to be heterozygous for hemoglobins jbaltimore and s. malignant transformation in fibrous dysplasia is unusual and may be associated in some individuals with prior irradiation. soft tissue myxomas associated with f ...19863456858
the role of computerized microdiscs in dentistry. 20083462054
jco/interviews dr. bjorn u. zachrisson on excellence in finishing. part 2. 20123462201
[behavior of oxygen pressure in muscle (po2) in healthy subjects and in patients with intermittent claudication following standardized foot ergometric exercise]. 20123464140
combined evaluation of some tumor associated antigens in the monitoring of integrated surgical and chemotherapeutic treatment of epithelial ovarian cancer.the authors measured the presurgical serum levels of some tumor associated antigens in 36 patients bearing primitive ovarian carcinoma and in 284 controls. ca125, which has shown a sensitivity (se) of 63.8% and a specificity (sp) of 92.6%, was elevated especially in serous and undifferentiated carcinomas, while ca19-9 (se = 33.3% and sp = 89.7%) and cea (se = 19.4% and sp = 96.4%) were more often pathological in mucinous ones. tpa (se = 75.0% and sp = 81.3%) had no particular correlation with an ...20123465535
treatment of external resorption by a combined endodontic-periodontic procedure. 20123465861
focal dermal hypoplasia syndrome (goltz syndrome): the first dental case report. 20123466146
[characteristics of nasal breathing and of the surgical procedure in nose deformities following the primary operation for unilateral cleft upper lip]. 20123472396
a study of the words used to describe pain. 20053481252
actions of prostaglandins e2 and f2 alpha on release of 14c-labelled mucins from rat submandibular salivary acini in vitro.mucin secretion was studied in vitro using well-characterized preparations of isolated acini. pge2 significantly (p less than 0.05) increased release of [14c]-glucosamine labelled mucins at the highest concentration tested (10(-5) m), but was ineffective at lower doses (10(-9)-10(-6) m). pgf2 alpha had no effect on mucin secretion over this concentration range. pge2 (10(-9)-10(-5) m) did not modify isoproterenol stimulated mucin secretion. the cyclooxygenase inhibitor indomethacin (10(-7)-10(-5) ...19873482153
[mercury content of the pulp in unfilled and amalgam-filled teeth]. 20123483683
studies of cellular retinol-binding protein (crbp) in squamous-cell carcinomas of the head and neck region.cellular retinol-binding protein (crbp) concentration was determined by radioimmunoassay in biopsies from normal mucosa and squamous-cell cancers of the head and neck region in 26 patients. the plasma concentrations of retinol, retinol-binding protein (rbp), prealbumin, albumin, orosomucoid and alfa1-antitrypsin were also determined. in all patients the tumours contained significantly higher concentrations of crbp (median = 185 micrograms/g tissue protein; range: 27-1,017 micrograms/g) than norm ...20123484732
immune responses to h-2kd antigen expressed by recombinant vaccinia virus.a recombinant vaccinia virus (vv-h2kd-6) containing the coding sequence for the murine major histocompatibility complex class i antigen h-2kd has been constructed and used to express h-2kd on the surface of infected cells. vaccinia expressed h-2kd has been shown to generate an h-2kd-specific primary cytotoxic t-cell response in mice infected with the recombinant virus and to stimulate an h-2kd-specific cytotoxic t-cell response in vitro. cells infected with the recombinant virus acted as targets ...19863489941
a case of human b cell leukemia that implicates an autocrine mechanism in the abnormal growth of leu 1 b cells.production of b cell growth factor (bcgf) from b-chronic lymphocytic leukemia (b-cll) cells was demonstrated. freshly isolated monoclonal b-cll cells expressed surface mu, delta, b1, and leu 1, but not ba (an antigen expressed only on activated b cells). upon stimulation with anti-igm, they secreted bcgf, which could act on anti-igm-stimulated autologous leukemic cells as well as anti-igm-stimulated normal b cells. cell lines established from these leukemic cells also constitutively secreted bcg ...19863490495
development of vaccines against shigellosis: memorandum from a who meeting.endemic shigellosis is a worldwide problem, with a high morbidity rate in most developing countries; substantial mortality may also occur, especially with disease caused by shigella dysenteriae serotype 1. the limited efficacy of current measures to control this infection makes the development of vaccines for the prevention of shigellosis particularly important. this memorandum describes the clinical features of and immunity to shigellosis, summarizes the present status of efforts to develop sui ...19873495364
dexamethasone pre-treatment is antipyretic toward polyinosinic: polycytidylic acid, lipopolysaccharide and interleukin 1/endogenous pyrogen.the effect of intravenously injected dexamethasone on the febrile response of rabbits to polyinosinic: polycytidylic acid (poly i:c), lipopolysaccharide (lps) and interleukin 1/endogenous pyrogen (il1/e.p.) was studied. dexamethasone (1 mg/kg) attenuated the febrile response to poly i:c (5 micrograms/kg) but only if administered between 0.5 to 2 h before poly i:c. if it was given after poly i:c this resulted in a potentiation of the fever. antagonism of the febrile response to poly i:c by dexame ...19873495738
infectious interstitial emphysema in aids. 20123497367
idiopathic production of interleukin-1 in acquired immune deficiency syndrome.we determined the capacity of peripheral blood monocytes from 19 patients with acquired immune deficiency syndrome (aids) or related conditions (1 with lymphadenopathy, 8 with aids-related complex, and 10 with aids) to produce intracellular and extracellular interleukin-1 (il-1) spontaneously and upon stimulation with bacterial endotoxin. all patients were anti-human t-cell lymphotropic virus type iii antibody positive. results were compared with those obtained with 10 normal controls of similar ...19873498739
production and assay of ovine t cell growth factor by concanavalin a stimulated peripheral blood leukocytes.conditions for the production and assay of ovine t cell growth factor (tcgf) activity were evaluated. peripheral blood leukocytes were stimulated with concanavalin a (con a) in the presence of 2% autologous serum or serum-free media. supernatants were harvested after 30 hr and concentrated for further characterization. a 28 hr proliferation assay with 2.5 x 10(4) 24 hr con a blasts per well was optimal for detection of tcgf. peak tcgf activity occurred with a 30-37 kd molecular weight fraction. ...19873499702
[substantiation of using pancreatic galvanization in the treatment of acute pancreatitis]. 19873502158
analysis of leukemic blast growth factor (lbgf) and autocrine secretion of csf by leukemic blasts. 20123502308
a framework for coping with stress and its application in patient care. 20123509707
dog inactive renin: biochemical characterization and secretion into renal plasma and lymph.it has been suggested that the dog is a useful model for studies of inactive renin (ir). however, the nature and origin of the trypsin-activated angiotensin-forming activity in dog plasma have not been fully defined. we characterized dog ir using renin-specific antibody, immunoaffinity, and affigel blue chromatography. activated ir resembles renal and plasma active renin in biochemical and immunological properties. ir was detected in renal lymph, arterial and venous plasma, as well as renal extr ...19863510560
shigellaemia in adults: case reports and literature review. 19863510864
rectal histology in acute bacillary dysentery.a recent epidemic of acute shigella dysentery in west bengal (india) provided us with an opportunity to examine the rectal mucosal abnormalities seen in this condition. one hundred two patients were investigated using sigmoidoscopy, rectal biopsy, and rectal swab for culture. pure culture of shigella was obtained in 37 cases, and the rectal biopsy specimens from these patients were assessed in detail. the mean (+/- sd) duration of illness was 47.8 +/- 27.4 h (range 8-120 h), and most patients (3 ...19863510937
colonic perforation in shigella dysenteriae 1 infection. 19863511451
renal transplantation in end stage renal disease patients with existing urinary diversion.from 1971 to 1984 renal transplantation was performed in 20 patients with end stage renal disease who presented with an existing form of urinary diversion. these patients were evaluated with a cystometrogram, voiding cystourethrogram and cystoscopy. in some cases bladder function was studied further by cycling through a suprapubically placed catheter. the bladder was considered unstable in 13 patients and undiversion was done at transplantation. the period of prior diversion ranged from 3 to 20 ...20123514957
ultrastructural pathology of the rectal mucosa in shigella dysentery.colonocyte damage in the rectal mucosa in shigellosis is the result of bacterial invasion and leads to ulceration. additional factors in colonocyte damage may be the shigella cytotoxin and, especially in colonic crypt cells, bacterial endotoxin. a vascular lesion was present in the lamina propria of the rectal mucosa, which resembled endothelial damage secondary to bacterial endotoxins. in patients with longer duration of symptoms, relative vascular insufficiency, activated lymphocytes, eosinoph ...19863515957
[development of the classification of bacteria in the genus shigella]. 19863518304
prevention of traveler's diarrhea by the tablet form of bismuth subsalicylate.in a randomized double-blind study, swiss adults traveling to tropical countries for 12 to 28 days took a solid formulation of bismuth subsalicylate (1.05 or 2.1 g/day on a twice-daily regimen) or placebo. efficacy was evaluated in 231 volunteers. diarrheal incidence was reduced by 41% in persons taking the high dose (p = 0.007) and by 35% in those taking the low dose (p = 0.03) with excellent compliance. no serious adverse reactions occurred, but objectionable taste, constipation, and nausea we ...19863518624
comparative efficacies of single intravenous doses of ceftriaxone and ampicillin for shigellosis in a placebo-controlled trial.to evaluate ceftriaxone for the treatment of shigellosis, 94 adult males with acute dysentery were randomly assigned to receive ceftriaxone (1 g), ampicillin (4 g), or saline placebo intravenously in single doses in a double-blind design. stool cultures were positive for shigella dysenteriae in 52 patients, s. flexneri in 38 patients, and other species in 4 patients. both ceftriaxone and ampicillin caused reductions in the mean duration of fever and the means of daily stool frequency 2 to 4 days ...19863518625
immunocytochemical localization of cathepsin b in rat kidney. ii. electron microscopic study using the protein a-gold technique.thin sections of lowicryl k4m-embedded materials were labeled with protein a-gold complex. gold particles representing the antigen sites for cathepsin b were exclusively confined to lysosomes of each segment of the nephron. the heaviest labeling was noted in the lysosomes of the s1 segment of the proximal tubules. labeling intensity varied considerably with the individual lysosomes. lysosomes of the other tubular segments, such as the s2 and s3 segments of the proximal tubules, distal convoluted ...19863519753
the relation between production of cytotoxin and clinical features in shigellosis.the relation between in vitro production of hela cell cytotoxin by strains of shigella and clinical symptomatology was determined for 35 travelers from the united states who developed shigellosis in guadalajara, mexico. there were 25 patients with shigella sonnei, eight with shigella flexneri, one with shigella boydii, and one with shigella dysenteriae. these strains were evaluated for in vitro production of cytotoxin. the amount of cytotoxin did not correlate with the number of stools passed, t ...19863519788
pathogenesis of shigella diarrhea. xi. isolation of a shigella toxin-binding glycolipid from rabbit jejunum and hela cells and its identification as globotriaosylceramide.a glycolipid that specifically binds shigella toxin was isolated from both hela cells and rabbit jejunal mucosa and identified as globotriaosylceramide (gb3) by its identical mobility on hptlc to authentic erythrocyte gb3. toxin also bound to a band tentatively identified as alpha-hydroxylated gb3. in addition, toxin bound to p1 antigen present in group b human erythrocyte glycolipid extracts. the common feature of the three binding glycolipids is a terminal gal alpha 1----4gal disaccharide link ...19863519828
prevalence of bronchial hyperresponsiveness in highly trained athletes.previous studies indicated that the prevalence of symptomatic asthma is about 4 to 7 percent. no similar studies exist to suggest the prevalence of asthma in highly trained competitive athletes, since asthma is thought to be an uncommon disease in this population. we became concerned, therefore, when a large number of football players developed symptoms consistent with asthma during preparation in california for the rose bowl in december 1981. we studied the team and found 12 percent of the foot ...20123522119
two toxin-converting phages from escherichia coli o157:h7 strain 933 encode antigenically distinct toxins with similar biologic activities.escherichia coli o157:h7 strain 933 contains two distinct toxin-converting phages (933j and 933w). the biologic activities and antigenic relationship between the toxins produced by 933j and 933w lysogens of e. coli k-12, as well as the homology of the genes that encode the two toxins, were examined in this study. the 933j and 933w toxins, like shiga toxin produced by shigella dysenteriae type 1, were cytotoxic for the same cell lines, caused paralysis and death in mice, and caused fluid accumula ...19863522426
enzyme-linked immunosorbent assay for shigella toxin.an enzyme-linked immunosorbent assay (elisa) was developed for the detection of shigella toxin. for the assay, a mouse monoclonal antibody against the b subunit of the toxin and a rabbit polyclonal antibody against the holotoxin were employed. the monoclonal antibody was used to coat wells of a microtiter plate, and the polyclonal antibody preparation was used as the detecting antibody. the amount of bound polyclonal antibody was determined by using a goat anti-rabbit immunoglobulin g-alkaline p ...19863522627
measurement of monoclonal immunoglobulin concentrations in hybridoma cultures by competitive inhibition enzyme immunoassay. 20123523131
blood glucose control and diabetic complications.two hypotheses have been advanced to explain the appearance of microvascular complications in diabetic patients with glycemic control. the genetic hypothesis suggests that the development of diabetic complications is genetically determined and independent of diabetic control, whereas the metabolic hypothesis suggests that long-term hyperglycemia causes the subsequent development of small-blood-vessel complications. we review data that either support or reject these hypotheses and suggest a third ...20123524339
comparison of norfloxacin and nalidixic acid for treatment of dysentery caused by shigella dysenteriae type 1 in adults.a severe epidemic of dysentery began late in 1979 in northeast zaire and spread to rwanda, burundi, and tanzania. the epidemic strain is a multiply resistant shigella dysenteriae type 1, which acquired resistance against trimethoprim and more recently against nalidixic acid in the course of the epidemic. a comparative open trial in rwandan adults with shiga dysentery involved 18 patients treated with norfloxacin at 400 mg twice daily and 12 patients treated with nalidixic acid at 1 g three times ...19863524434
oral biopsy technique. the pathologist's perspective. 20123524767
specific detection of plasmodium falciparum malaria by a molecularly cloned dna probe.a highly repeated dna sequence from plasmodium falciparum was cloned and used as a probe in molecular hybridization to detect malaria. our results indicate that the probe is specific to p. falciparum but not to other species of plasmodium and is extremely sensitive. as little as a 20 pg parasite dna, which is equivalent to about 1000 parasites can be detected. the cloned dna can be used as a diagnostic tool to follow the course of infection of falciparum malaria.19863527161
bacterial toxins and diarrhoea.bacteria and their toxins are responsible for an enormous burden of diarrhoeal disease. knowledge about the toxins and their mechanisms of action is limited. thus, although considerable information is available about the mechanism of action of cholera toxin and a small number of heat-stable enterotoxins, information on the role and action of many others is incomplete. the demonstration of a toxic effect in a test system does not necessarily imply that that activity is relevant to the pathogenesi ...19863527494
multiply drug-resistant shigella dysenteriae type 1 and travelers' diarrhea. 19863528325
regulation of adenovirus mrna formation. 19863529876
fetal epithelial binding of 1,2-dibromoethane in mice.whole-body autoradiography and computer-assisted image analysis were used to study the tissue binding of the volatile carcinogenic pesticide 1,2-dibromo[14c]ethane (dbe) in c57bl mouse fetuses. autoradiograms obtained from pregnant mice in late gestation (day 16-17), showed a high level of non-volatile metabolites in the epithelia of the fetal upper alimentary tract and respiratory tract. as determined by image analysis, the concentration of non-extractable (presumably covalently bound) metaboli ...19863530523
comparison of dna probes and the sereny test for identification of invasive shigella and escherichia coli strains.forty-two shigella and 29 escherichia coli strains were screened for invasiveness in the sereny test and for hybridization with two recently described dna probes for the invasiveness plasmid. both probes produced identical results. all sereny-positive strains hybridized with both dna probes. three sereny-negative strains also hybridized with the probes, suggesting that there are strains containing the invasiveness plasmid that are not pathogenic in animal models.19863531233
the emergence of sick children's nursing. part 1. sick children's nursing before the turn of the century. 20123531803
the emergence of sick children's nursing. part 1. sick children's nursing before the turn of the century. 20123531803
adrenal steroid receptors and actions in the nervous system. 20123532143
a rapid hplc method for monitoring plasma levels of caffeine and theophylline using solid phase extraction columns.a simple hplc method for the determination of caffeine and theophylline in plasma is described. separation of theobromine, paraxanthine, theophylline, beta-hydroxyethyltheophylline and caffeine is obtained using a mobile phase of 1% acetic acid/methanol (83:17, v/v) and a waters associates nova-pak c18 column protected by a guard-pak precolumn module containing a guard-pak cn cartridge. rapid sample preparation is achieved by solid-phase extraction columns (bond-elut c18, 1 ml capacity) which pr ...20123532920
an epidemic of bacillary dysentery in western rwanda 1981-1982.the epidemiologic and clinical aspects of a major shigella dysenteriae epidemic resistant to all available drugs that occurred in western rwanda in 1981-82 are analyzed. about 5% of the population was affected. in total, there were 11,801 cases of dysentery, with an average of 833 cases/month. the course of the epidemic was independent from seasonal variations. in children under 5 years of age, the majority (61%) of dysentery cases involved males; at all other ages, however, there was a femal ...19863533269
[prevalence and care of patients with proteus mirabilis enteritis]. 19863533289
[prevalence and care of patients with proteus mirabilis enteritis]. 19863533289
septic pylephlebitis following shigella bacteremia: case report. 19863535150
morphologic evaluation of the effects of shiga toxin and e coli shiga-like toxin on the rabbit intestine.the effects of a shiga toxin derived from shigella dysenteriae type 1, strain 60r, and a shiga-like toxin from the enterohemorrhagic escherichia coli o157:h7, strain 933, were studied in the in vivo rabbit ileal loop model. the effects of both toxins were similar and resulted in severe villus blunting by 18-24 hours after exposure. with both toxins, a dose effect was noted; and the lesions, first detected at 2 hours after inoculation, became more severe over time. both toxins appeared to act dir ...19863535529
shigella dysenteriae type 1 enterocolitis.shigella dysenteriae type 1 is much more virulent than shigella flexneri and sonnei which are endemic in australia. this report describes a 22 year old woman who acquired shigella dysenteriae type 1 whilst travelling in india. during the course of her illness, she developed severe enterocolitis for which a subtotal colectomy was performed. the illness resembled fulminant ulcerative colitis and its infectious nature was difficult to establish because several fecal cultures failed to grow the path ...19863535768
double-blind controlled trial to compare anti-inflammatory effects of tolmetin 2%, prednisolone 0.5%, and placebo in post-cataract extraction eyes.this paper compares the efficacy of tolmetin, prednisolone, and placebo (vehicle only) in controlling post-cataract extraction inflammation in a double-blind trial involving 120 patients. seventeen patients were excluded from analysis. the results of the 103 patients analysed showed that 94% of the prednisolone treated group was judged to have been successfully treated as compared with 53% of the tolmetin treated group and 46% of the vehicle treated group. the differences between the prednisolon ...20123535872
interactions of oncogenes with haematopoietic cells. 20133536235
infertility as caused by sperm antibodies. 20123536681
production of shiga toxin and other cytotoxins by serogroups of shigella.we measured the cytotoxic activity of 119 strains of shigella by using a quantitative [3h]thymidine-labeled hela cell assay. we assayed 13 strains of shigella dysenteriae 1; 18 strains of s. dysenteriae types 2 and 3; and 88 strains of shigella sonnei, shigella flexneri, and shigella boydii. strains of s. dysenteriae 1 demonstrated high levels of cytotoxicity (geometric mean, 10(5.04) cd50/mg of protein; range, 10(3.95)-10(6.10). cytotoxic activities of the non-type 1 strains of s. dysenteriae a ...19863537154
enzyme-linked immunosorbent assay to detect shiga toxin of shigella dysenteriae and related toxins.a sandwich enzyme-linked immunosorbent assay (elisa) was developed for detection of shiga toxin. four species of shigella, escherichia coli, and vibro parahaemolyticus were tested for production of shiga or shiga-like toxin by elisa and vero cell bioassay. in the elisa, most strains of s. dysenteriae and some strains of e. coli isolated from traveler's diarrhea were positive. these elisa-positive strains were positive by vero cell bioassay without exception. some e. coli strains and most v. para ...19873539985
[bacteriological study of shigellosis in the lake kivu area (central africa). developments in the last 15 years (1968-1983)].1913 shigella strains were isolated from 1968 to 1983 in lake kivu area (central africa). distribution and evolution of serotypes, biotypes and antibiotypes were studied. the majority of serotypes and biotypes were stable. however, few of these strains showed variations, among them shigella dysenteriae serotype 1, causing epidemic dysenteriae since 1981. epidemiologic survey of shigellosis in kivu seems to be rather underdeveloped (4 bacteriology laboratories for an area of 10 million inhabitant ...19863542256
ionic requirements for entry of shiga toxin from shigella dysenteriae 1 into cells.the ionic requirements for entry of shiga toxin into cells were examined by measuring inhibition of protein synthesis after short-term incubations with toxin. the sensitivity of vero cells and hela cells to shiga toxin was strongly dependent on the divalent cation present. vero cells were most sensitive in the presence of cacl2 and srcl2, whereas hela cells were equally sensitive in the presence of mgcl2, srcl2, and cacl2. both cell lines were protected by bacl2, cocl2, and mncl2. inhibitors of ...19873542829
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