Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| phenotypic and genotypic characterization of shigella spp. with reference to its virulence genes and antibiogram analysis from river narmada. | water samples of the river narmada from origin to end were analyzed for the presence of shigellae. analysis of 40 water samples by biotyping, serotyping, and molecular typing were done. out of all 40 isolates, 23 were identified as shigella flexneri, 10 as shigella sonnei, and seven as shigella dysenteriae. serotyping was found to be a better identification method than biotyping since biotyping was not found to be very sharp. in the present investigation, amplified ribosomal dna restriction anal ... | 2010 | 19501495 |
| lactobacilli inhibit shigella dysenteriae 1 induced pro-inflammatory response and cytotoxicity in host cells via impediment of shigella-host interactions. | shigella dysenteriae type 1 dysentery is a major cause of morbidity and mortality in children from less developed and developing countries. the present study explores the hypothesis that lactobacilli protect the host cell during s. dysenteriae type 1 infection and its mechanism of action. | 2010 | 19535308 |
| structure of the heme/hemoglobin outer membrane receptor shua from shigella dysenteriae: heme binding by an induced fit mechanism. | shigella dysentriae and other gram-negative human pathogens are able to use iron from heme bound to hemoglobin for growing. we solved at 2.6 a resolution the 3d structure of the tonb-dependent heme/hemoglobin outer membrane receptor shua from s. dysenteriae. shua binds to hemoglobin and transports heme across the outer membrane. the structure consists of a c-terminal domain that folds into a 22-stranded transmembrane beta-barrel, which is filled by the n-terminal plug domain. one distal histidin ... | 2010 | 19731368 |
| [rapid detection of shigella dysenteriae by pcr assay]. | based on the invasive plasmid antigen h gene (ipah) of s. dysenteriae, one pair of specific primers was designed for pcr assays in this study. the concentrations of dntp, mg2+ and primer, dosage of taq dna polymerase, annealing temperature and circulating parameter in the pcr amplification system were optimized. in this way, a rapid and stable method of pcr assay for the detection of s. dysenteriae was established. the specificity and sensitivity of pcr were also analyzed. the detection limits o ... | 2010 | 21033439 |
| imperatorin a furocoumarin inhibits periplasmic cu-zn sod of shigella dysenteriae their by modulates its resistance towards phagocytosis during host pathogen interaction. | shigella dysenteriae continues to be a major health problem, which leads to death, due to diarrhoea and dysentery, predominantly in children below the age of 5. bacterial invasion of the colonic epithelium leads to severe inflammation together with bacterial dissemination generates abscesses and ulcerations. periplasmic copper, zinc super oxide dismutase of shigella protects it from exogenous superoxide produced by host, during its invasion. hence, in present study an attempt was made to study t ... | 2010 | 21194882 |
| synthesis and evaluation of a class of new coumarin triazole derivatives as potential antimicrobial agents. | a series of new coumarin-based 1,2,4-triazole derivatives were designed, synthesized and evaluated for their antimicrobial activities in vitro against four gram-positive bacteria (staphylococcus aureus, mrsa, bacillus subtilis and micrococcus luteus), four gram-negative bacteria (escherichia coli, proteus vulgaris, salmonella typhi and shigella dysenteriae) as well as three fungi (candida albicans, saccharomyces cerevisiae and aspergillus fumigatus) by two-fold serial dilution technique. the bio ... | 2010 | 21215620 |
| the structure of the escherichia coli o148 lipopolysaccharide core region and its linkage to the o-specific polysaccharide. | recently it was demonstrated that shigella dysenteriae type 1, a cause of severe dysentery epidemics, gained its o-specific polysaccharide (o-sp) from escherichia coli o148. the o-sps of these bacteria differ only by a galactose residue in the repeat unit of s. dysenteriae type 1 in place of a glucose residue in e. coli o148. herein, we analyzed the core structure and its linkage to the o-sp in e. coli o148 lps. both were found to be identical to those of s. dysenteriae type 1 structures, furthe ... | 2010 | 21074753 |
| thrombotic microangiopathies: thrombotic thrombocytopenic purpura / hemolytic uremic syndrome. | thrombotic microangiopathies (tmas) are pathological conditions characterized by generalized microvascular occlusion by platelet thrombi, thrombocytopenia, and microangiopathic hemolytic anemia. two typical phenotypes of tmas are hemolytic- uremic syndrome (hus) and thrombotic thrombocytopenic purpura (ttp). other disorders occasionally present with similar manifestations. depending on whether renal or brain lesions prevail, two pathologically indistinguishable but somehow clinically different d ... | 2010 | 21103695 |
| facile synthesis and antibacterial activity of naturally occurring 5-methoxyfuroflavone. | a convenient synthesis of 5-methoxyfuroflavone (6, pongaglabol methyl ether), a constituent of some pongamia or millettia genus, was achieved by starting from 2,4-dihydroxy-6-methoxyacetophenone via a chalcone precursor, followed by treatment with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (ddq). this five-step reaction (total yield: 21.6%) is more facile with that of previously utilized procedures using each different starting material. antibacterial activities of the above compound and its prec ... | 2010 | 21139271 |
| research progress in shigella in the postgenomic era. | gram-negative, facultative intracellular anaerobes of the genus shigella, the principal etiologic agents of shigellosis, continue to pose a threat to public health. shigellosis causes 1.1 million deaths with over 164 million annual cases. the shigella spp. can be divided into four serogroups: shigella dysenteriae, shigella flexneri, shigella boydii and shigella sonnei. the completion of seven shigella genome sequences of representative strains from each of the shigella species has introduced an ... | 2010 | 21046319 |
| [detection and drug resistance analysis of extended-spectrum beta-lactamases-producing shigella in pediatric patients]. | to investigate the occurrence and drug resistance of extended-spectrum beta-lactamases (esbls)-producing strains of shigella in pediatric patients, so as to provide information for clinical treatment. | 2010 | 21055309 |
| development of a quantitative rt-pcr assay to examine the kinetics of ribosome depurination by ribosome inactivating proteins using saccharomyces cerevisiae as a model. | ricin produced by the castor bean plant and shiga toxins produced by pathogenic escherichia coli (stec) and shigella dysenteriae are type ii ribosome inactivating proteins (rips), containing an enzymatically active a subunit that inhibits protein synthesis by removing an adenine from the α-sarcin/ricin loop (srl) of the 28s rrna. there are currently no known antidotes to shiga toxin or ricin, and the ability to screen large chemical libraries for inhibitors has been hindered by lack of quantitat ... | 2010 | 21098653 |
| convergent synthesis of a common pentasaccharide corresponding to the o-antigen of escherichia coli o168 and shigella dysenteriae type 4. | a convenient synthetic strategy of the common acidic pentasaccharide repeating unit corresponding to the o-antigen of enterotoxigenic e. coli o168 and shigella dysenteriae type 4 has been successfully developed. a stereoselective [2 + 3] block glycosylation method has been exploited to get the target pentasaccharide derivative. most of the synthetic intermediates were solid and prepared in high yields from commercially available reducing sugars following a series of protection-deprotection react ... | 2010 | 21181263 |
| plasmon-induced inactivation of enteric pathogenic microorganisms with ag-agi/al2o3 under visible-light irradiation. | the plasmon-induced photocatalytic inactivation of enteric pathogenic microorganisms in water using ag-agi/al(2)o(3) under visible-light irradiation was investigated. the catalyst was found to be highly effective at killing shigella dysenteriae (s. dysenteriae), escherichia coli (e. coli), and human rotavirus type 2 wa (hrv-wa). its bactericidal efficiency was significantly enhanced by hco(3)(-) and so(4)(2-) ions, which are common in water, while phosphate had a slightly positive effect on the ... | 2010 | 20734989 |
| transmembrane bax inhibitor motif containing (tmbim) family proteins perturbs a trans-golgi network enzyme, gb3 synthase, and reduces gb3 biosynthesis. | globotriaosylceramide (gb3) is a well known receptor for shiga toxin (stx), produced by enterohemorrhagic escherichia coli and shigella dysenteriae. the expression of gb3 also affects several diseases, including cancer metastasis and fabry disease, which prompted us to look for factors involved in its metabolism. in the present study, we isolated two cdnas that conferred resistance to stx-induced cell death in hela cells by expression cloning: ganglioside gm3 synthase and the cooh terminus regio ... | 2010 | 20837469 |
| characterization and antimicrobial activity of 4-(β-d-glucopyranosyl-1→4-α-l-rhamnopyranosyloxy)-benzyl thiocarboxamide; a novel bioactive compound from moringa oleifera seed extract. | antimicrobial activity of crude seed extract of moringa oleifera was investigated by thin layer chromatography bioassay against escherichia coli, pseudomonas aeruginosa, staphylococcus aureus, cladosporium cladosporioides, and penicillium sclerotigenum; most of them were prominently inhibited by an isolate with r(f) 0.92-0.96. characterization and identification of the extract revealed the occurrence of three bioactive compounds: 4-(α-l-rhamnopyranosyloxy)benzyl isothiocyanate, methyl n-4-(α-l-r ... | 2010 | 20941575 |
| [endodontic approach to injured teeth]. | 2010 | 2897345 | |
| shiga toxin is transported into the nucleoli of intestinal epithelial cells via a carrier-dependent process. | shiga toxin (stx) produced by the invasive shigella dysenteriae serotype 1 (s. dysenteriae1) causes gastrointestinal and kidney complications. it has been assumed that stx is released intracellularly after enterocyte invasion by s. dysenteriae1. however, there is little information about stx distribution inside s. dysenteriae1-infected enterocytes. here, we use intestinal epithelial t84 cells to characterize the trafficking of stx delivered into the cytosol, in ways that mimic aspects of s. dyse ... | 2010 | 22069640 |
| mixed infections of vibrio cholerae o1 ogawa el tor with shigella dysenteriae. | mixed infections caused by enteric pathogens such as bacteria, virus, protozoa and helminthes were reported in different literatures. this report also describes the co-infections caused by vibrio cholerae o1 ogawa el tor with shigella dysenteriae in a patient. a 36-year-old man was admitted in fatemeh zahra hospital of bushehr iran with fever, vomiting and dysentery. his stool sample was cultured, for identification purposes tcbs, xld and other media were used. v. cholerae and s. dysenteriae wer ... | 2010 | 21313886 |
| virulence of environmental stenotrophomonas maltophilia serologically cross-reacting with shigella-specific antisera. | this research involved an environmental strain of stenotrophomonas maltophilia which has been reported to produce serological cross-reactivity with shigella dysenteriae type 8 specific antisera. since clinical diagnosis of shigellosis is largely based on culture and serology, the investigation was aimed at in vivo and in vitro virulence comparison between the culturally similar environmental s. maltophilia isolate and the reference s. dysenteriae strains. the findings of this study revealed the ... | 2010 | 21313916 |
| shiga toxins: intracellular trafficking to the er leading to activation of host cell stress responses. | despite efforts to improve hygenic conditions and regulate food and drinking water safety, the enteric pathogens, shiga toxin-producing escherichia coli (stec) and shigella dysenteriae serotype 1 remain major public health concerns due to widespread outbreaks and the severity of extra-intestinal diseases they cause, including acute renal failure and central nervous system complications. shiga toxins are the key virulence factors expressed by these pathogens mediating extra-intestinal disease. de ... | 2010 | 22069648 |
| focus on scotland. taking the high road. interview by sue smith. | 2010 | 2920555 | |
| [clinical survey on adverse reactions of contrast media (2d report)]. | 2010 | 2950377 | |
| [horizontal laparotomy in biliary tract surgery]. | for operations on the biliary tract the transverse horizontal incision has the same advantages as the subcostal approach: strong abdominal wall, little influence on ventilation and wide access to the subhepatic region. but in addition, the abdominal wall nerves are preserved as much as possible, post-operative evisceration, it is occurs, can easily be repaired and subsequent surgery can be performed using the same route. | 2010 | 2934697 |
| neuron-specific enolase in the diagnosis of small-cell lung cancer with pleural effusion: a negative report. | we measured the concentration of neuron-specific enolase (nse) and carcinoembryonic antigen (cea) in the serum and pleural fluid of 53 patients with pleural effusions, including seven patients with small-cell lung cancer (sclc). high levels (above 12.5 micrograms.l-1) of nse in pleural fluid were observed in five patients with sclc (sensitivity 71%). however, pleural fluid nse levels were also increased in five patients with other types of cancer and in four patients with non-malignant inflammat ... | 2010 | 2853080 |
| blood concentration and urinary excretion of enalapril in patients with chronic renal failure. | 2010 | 3003431 | |
| comparison of atracurium and d-tubocurarine for prevention of succinylcholine myalgia. | we compared the incidence of postoperative myalgia (pom) and fasciculations when atracurium (atr) or d-tubocurarine (dtc) was given prior to succinylcholine (sdc) for tracheal intubation in 44 asa class i or ii outpatient females undergoing laparoscopy. the subjects were assigned to one of three groups: group 1 received 0.025 mg/kg atr; group 2 received 0.05 mg/kg dtc; and group 3 received saline (ns), all in a double-blind manner. thiopental was administered 1 min and 45 sec after pretreatment ... | 2010 | 2955717 |
| lowering effect of pantethine on plasma beta-thromboglobulin and lipids in diabetes mellitus. | pantethine in a dosage of 600 mg for the first 3 months, and in a dosage of 1200 mg for the second 6 months was given to 16 diabetics in whom plasma beta-thromboglobulin was raised (greater than 50 ng/ml). plasma beta-tg levels decreased significantly with pantethine treatment for 9 months. plasma triglyceride, total cholesterol, apo e and apo cii levels decreased significantly after 9 months. plasma ldl-c and atherogenic index (ldl-c/hdl-c ratio or apo b/apo ai ratio) tended to decrease with tr ... | 2010 | 2963604 |
| antiprotease capacity in acute pancreatitis. | serial measurements of circulating antiproteases were carried out on 42 consecutive patients admitted with acute pancreatitis. in the 7 days following admission the serum levels of alpha 1 antitrypsin (alpha 1 at), alpha 1 antichymotrypsin (alpha 1 act) and the trypsin inhibitory capacity (tic) increased by more than 300 per cent. the serum concentration of alpha 2 macroglobulin (alpha 2 m) alone showed a decline which was most profound in those patients with severe acute pancreatitis. initial e ... | 2010 | 3768647 |
| [therapy of carcinoma in situ]. | 2010 | 4034075 | |
| transfer of pre-embryos donated and fertilized in vivo to recipients given a steroid replacement therapy. | this study describes eleven procedures of non-surgical recovery of preimplantation conceptuses from the uteri of eight fertile donor women and the transfer of the recovered pre-embryos into the uteri of infertile recipients with primary ovarian failure, or with hypothalamic--pituitary failure. conjugated oestrogens and progesterone were administered to recipients as replacement steroids during the first 20 weeks of pregnancy, in order to produce a secretory endometrium allowing nidation and deve ... | 2010 | 2851614 |
| attractive propositions: microbial responses to chemical signals. | 2010 | 3153179 | |
| plasma atrial natriuretic peptide concentrations during induction of anesthesia and acute volume loading in patients undergoing cardiac surgery. | induction of anesthesia with fentanyl for coronary artery bypass grafting decreased (p less than .05) plasma atrial natriuretic peptide (anp) concentrations from awake values in twelve patients. during a steady state of anesthesia before surgery, isotonic saline solution (10 ml/kg) was infused simultaneously with the elevation of the lower extremities in six patients, while six subjects served as controls receiving no volume loading and having no leg raising. the anp levels returned to the awake ... | 2010 | 2980951 |
| anticholinergic drugs in the treatment of airways disease. | 2010 | 2861843 | |
| [pathological aging of the brain. personal observations on the use of citicoline]. | 2010 | 2973933 | |
| [nutrition in the etiology of breast cancer. results of a survey in austria]. | 2010 | 2934651 | |
| principles of the diagnostic system 'orfèvre' for computerized analysis in radiology. | 2010 | 2980470 | |
| [the treatment of severe, therapy-resistant depression using infusions of antidepressants]. | infusion-therapy with antidepressants has been of value in severe as well as therapy resistant depressive states. in addition to doses lower than those used for oral treatment, a more rapid onset of therapeutic effect and a better tolerance, the beneficial effect seems also to depend on the setting in which the treatment takes place. infusion-therapy is a combined pharmacopsychotherapeutic procedure. next to infusion-treatment a pretreatment with neuroleptics is advised either via the oral or pa ... | 2010 | 2922514 |
| midazolam in the intensive care unit. | 2010 | 3769775 | |
| why does placebo improve severe limb ischaemia? | 2010 | 2893161 | |
| desirable standards of performance for therapeutic drug monitoring. | therapeutic drug monitoring is an important aspect of clinical chemistry for which no objective analytical goals yet exist. based on fundamental pharmacokinetic theory, and the current consensus strategy for analytical goal-setting for precision based upon biological variation, a theoretical model allows derivation of the goal that: analytical cv less than or equal to 1/4 [(2t/t - 1)/(2t/t + 1)] x 100%, where t is the time interval between doses, and t is the average elimination half-life. using ... | 2010 | 3815803 |
| the use of dura mater allograft in the surgical repair of large defects of the abdominal wall. | the dura mater allograft is being used as an abdominal fascia substitute and major advantages are documented. it was used successfully in four patients at this institution, with a ten month follow-up period. its strength, durability, tissue tolerance, flexibility, ease of handling, nonallergenic property, availability and stability in the presence of infection make it a good graft to be used in the repair of large abdominal hernias. we are quite convinced that long term follow-up results will ve ... | 2010 | 3160130 |
| the use of dura mater allograft in the surgical repair of large defects of the abdominal wall. | the dura mater allograft is being used as an abdominal fascia substitute and major advantages are documented. it was used successfully in four patients at this institution, with a ten month follow-up period. its strength, durability, tissue tolerance, flexibility, ease of handling, nonallergenic property, availability and stability in the presence of infection make it a good graft to be used in the repair of large abdominal hernias. we are quite convinced that long term follow-up results will ve ... | 2010 | 3160130 |
| anal duct carcinoma. | 2010 | 2924675 | |
| abnormal systolic time intervals in obesity and their relationship with the amount of overweight. | we studied 17 severely obese subjects (age range 26 to 42 years), without hypertension, diabetes mellitus, angina, or clinical signs of heart failure or respiratory disease, and 16 age-matched control subjects. x-teleroentgenographic findings (transverse cardiac diameter and cardiothoracic ratio), blood pressure, and mechanocardiographic parameters were analyzed in both groups. by means of conventional simultaneous recordings of ecg, phonocardiogram, and carotid pulse (100 mm/sec), systolic time ... | 2010 | 2943149 |
| the incidence of cardiac arrhythmias during intravenous digital subtraction angiography: a comparison of peripheral and central injections. | intravenous digital subtraction arteriography (iv-dsa) was carried out in 204 patients with arteriosclerotic peripheral vascular disease using the non-ionic contrast medium iopamidol 370. in 124 patients the injection was made into an antecubital vein and in 80 into the right atrium. rhythm strip electrocardiograms showed no significant difference in incidence or type of arrhythmias between either injection method (p greater than 0.95). | 2010 | 2941437 |
| [the administration of calcium channel blockers in patients with cerebrovascular diseases]. | 2010 | 2922083 | |
| solvent interactions with n, n-dialkylnicotinamides and their effects on rotational barriers. | carbon-13 nuclear magnetic resonance techniques were employed to examine the effects of solvent environment on rotational barriers in a series of molecules structurally-related to the analeptic, nikethamide: n,n-dimethylnicotinamide, n,n-di-n-propylnicotinamide, and 1-nicotinoyl piperidine. total bandshape analysis was performed for the exchanging alkyl carbon resonances of these compounds as a function of temperature in four solvent systems: d2o, ch3od, ch3ch2od and cdcl3. the rate constants fo ... | 2010 | 2937406 |
| [fibrinolytic therapy of thromboembolic vascular occlusions: experiences based on 87 patients]. | 2010 | 2974192 | |
| microbial lipids betrayed by their fossils. | novel families of microbial lipids have been betrayed by their molecular fossils. they comprise the very widespread and varied hopanoids, and 'orphan' lipids. membrane reinforcement appears to be universally achieved by these polyterpenoids; a hypothetical phylogenetic tree comprises the above, some postulated intermediates, bacterial carotenoids, cycloartenol, and finally cholesterol. | 2010 | 3153170 |
| lateral diffusion of specific antibodies bound to lipid monolayers on alkylated substrates. | we have measured the lateral mobility of fluoresceinated monoclonal igg antibodies bound specifically to a spin label lipid hapten in phospholipid monolayers supported on alkylated silicon oxide surfaces. dimyristoyl phosphatidylcholine and dipalmitoyl phosphatidylcholine monolayers containing 5 mol% of the lipid hapten were transferred by conventional langmuir-blodgett techniques onto substrates alkylated with hydrocarbon chains containing 10, 16, and 18 carbon atoms. we show that the diffusion ... | 2010 | 3006037 |
| lateral diffusion of specific antibodies bound to lipid monolayers on alkylated substrates. | we have measured the lateral mobility of fluoresceinated monoclonal igg antibodies bound specifically to a spin label lipid hapten in phospholipid monolayers supported on alkylated silicon oxide surfaces. dimyristoyl phosphatidylcholine and dipalmitoyl phosphatidylcholine monolayers containing 5 mol% of the lipid hapten were transferred by conventional langmuir-blodgett techniques onto substrates alkylated with hydrocarbon chains containing 10, 16, and 18 carbon atoms. we show that the diffusion ... | 2010 | 3006037 |
| outcome of early surgery after coronary angioplasty. | nineteen of 69 patients undergoing coronary angioplasty required immediate coronary surgery after the procedure. six of these operations were planned as a result of angioplasty that failed without producing any complication. the remaining 13 cases were operated upon because complications occurred during angioplasty. these were coronary artery dissection in four, occlusion in five, continuing severe spasm in two, tamponade in one, and in one other detachment of a guidewire tip. in these 13 cases ... | 2010 | 2937432 |
| ciprostene in patients with peripheral vascular disease (pvd). an open-label, tolerance trial. | epoprostenol (prostacyclin) has been studied with various success in patients with peripheral vascular disease (pvd). we investigated the tolerance of a new, stable prostacyclin derivative ciprostene (9-beta-methyl carbacyclin) in 9 pvd patients. the drug was infused intravenously for 8 hours a day, once a week for 4 consecutive weeks, at a dose of 120 ng/kg/min. there were 6 men and 3 women with a mean age of 63 years (42-78). the pvd was verified by arteriography (9 patients) and by clinical f ... | 2010 | 3068680 |
| surgical streams in the flow of health care financing. the role of surgery in national expenditures: what costs are controllable? | the dollar flow in united states medical care has been analyzed in terms of a six-level model; this model and the gross 1981 flow data are set forth. of the estimated $310 billion expended in 1981, it is estimated that $85-$95 billion was the "surgical stream", i.e., that amount expended to take care of surgical patients at a variety of institutional types and including ambulatory care and surgeons' fees. some of the determinants of surgical flow are reviewed as well as controllable costs and ca ... | 2010 | 3918514 |
| [prevention of the problems of alcoholism]. | 2010 | 2975175 | |
| recent advances and controversies in childhood renal osteodystrophy. | renal osteodystrophy starts very early in chronic renal failure. although vitamin d levels are normal in patients with 70-80% function, the levels are not appropriate to the prevailing biochemical milieu. renal osteodystrophy may contribute to renal growth failure but a correlation between the degree of renal osteodystrophy and growth failure is not observed. catch-up growth cannot be obtained over a longer period of time with vitamin d. the main reason for osteomalacia is al intoxication. alumi ... | 2010 | 3153280 |
| hay fever treatments--which should be tried first? | a series of comparative trials on nine popular and pharmacologically distinct regimens for the treatment of hay fever was undertaken in the course of normal general practice in the pollen seasons of 1981-83. one hundred and forty doctors recruited 640 patients to assess the overall usefulness of the treatments on daily diaries. ;usefulness' was scored on a linear analogue scale weighing up the degree of hay fever symptoms during treatment, side effects and ease of use of the preparation.the regi ... | 2010 | 2896796 |
| uptake of 63ni2+ in the central and peripheral nervous system of mice after oral administration: effects of treatments with halogenated 8-hydroxyquinolines. | oral administration of 63ni2+ to mice resulted in higher levels of the metal in the sciatic nerves, the trigeminal ganglia, spinal nerve roots and the spinal cord than in the cerebellum and the frontal cortex. in the sciatic nerves, the trigeminal ganglia and the spinal nerve roots a high vascular permeability may explain the preferential uptake of the 63ni2+. the higher accumulation of the 63ni2+ in the spinal cord than in the examined structures of the brain may be related to a diffusion from ... | 2010 | 2916242 |
| continuous ecg monitoring of children with cancer receiving domperidone. | domperidone is an effective antiemetic for children receiving cytotoxic therapy. there have been reports of cardiac arrest in older patients associated with domperidone. we carried out continuous ecg monitoring of 18 children receiving domperidone intravenously in a dose of 1 mg/kg body weight. no serious dysrhythmias were noted during 379 h of recording. single premature beats, transient sinus pauses, and nodal block were occasionally associated with vomiting and were no more common than would ... | 2010 | 3153247 |
| [hormonal status of girls in the neutral, prepubertal and pubertal periods of life]. | 2010 | 2935044 | |
| bioactivity and immunoreactivity of tumour necrosis factor in cancer patients. | 2010 | 2893076 | |
| validity of an operational definition for neurotic unipolar major depression. | after we reviewed the literature to identify the clinical and phenomenologic correlates of neurotic depression, we constructed a 6-item operational definition to distinguish neurotic unipolar major depressive disorder from non-neurotic major depression. the neurotic depressives were characterized by a low rate of abnormal dexamethasone suppression test (dst) results and a strong family history of alcoholism. neurotic depressives improved less than non-neurotic depressives during the index hospit ... | 2010 | 2952692 |
| arrhythmia or artifact? | 2010 | 2916599 | |
| [screening of cancer, advantages and disadvantages]. | 2010 | 2916263 | |
| hodgkin's disease and non-hodgkin's lymphomas. | 2009 | 2670408 | |
| griseofulvin and ketoconazole in the treatment of dermatophyte infections. | 2009 | 2666321 | |
| regulation of plasminogen activators and their inhibitors in rheumatic diseases: new understanding and the potential for new directions. | over the past several years there has been a rapid expansion in our understanding of the fibrinolytic system. this includes knowledge of the components, availability of recombinant reagents and a better understanding of the regulation of fibrinolysis in health and disease. disturbances in the regulation of the balance between fibrin deposition and removal have been implicated in a number of inflammatory diseases including certain rheumatic diseases. this overview summarizes our knowledge of the ... | 2009 | 2681762 |
| [clinical significance of the quantification of obesity. the quetelet index and its use]. | the degree of obesity, ie. the quantity of excessive stored adipose tissue, affects substantially morbidity and mortality on cardiovascular, metabolic, and other diseases. while the quantity of an adipose tissue is practically impossible to determine, it is necessary to use the body weight, adjusted for the stature. the quetelet's index (body mass index, bmi) is the best one from height-weight indices. values of bmi define categories of normal weight, overweight, and obesity, which have differen ... | 2009 | 2790909 |
| [a three years follow-up study on the blood pressures of 6111 children in chengdu]. | this paper reports the results of a follow-up study in blood pressures of 6111 children for 3 years in chengdu city and the villages around. it was showed that the blood pressure for both the city and village children were elevated in overall with age. among the city children, the rate of bp-rising varied in different periods of childhood and that of girls above 13 was not significant. among village children, the rate of bp-rising for both male and female comparison to that of urban ones were si ... | 2009 | 2736619 |
| a case of acute psychosis in temporal association with theophylline toxicity. | 2009 | 2708558 | |
| pulmonary aspergillosis in immunosuppressed patients with haematological malignancies. | invasive pulmonary aspergillosis as a cause of mortality and morbidity in patients with haematological malignancies is becoming more common. predisposing factors are powerful immunosuppressive chemotherapy, neutropenia and synergistic combinations of antibiotics of great potency and wide spectrum of activity. clinical and radiological signs are heterogeneous, sometimes misleading and often absent. treatment is often empirical on suspicion alone. amphotericin b is the only effective drug but it h ... | 2009 | 3749452 |
| introduction to immunocytochemistry. | immunocytochemistry has opened a new era in research and diagnosis. the development of immunocytochemical methods has made it possible to identify in situ normal and pathological tissue constituents, which it has not been possible to detect using ordinary histological methods. however, immunocytochemical techniques involve several pitfalls, which without proper control protocols can easily lead to incorrect findings. when interpreting the results obtained, account must always be taken of the mor ... | 2009 | 2664772 |
| sonographic and pathological staging of patients with clinically localized prostate cancer. | we evaluated 64 patients with clinically localized prostate cancer (on the basis of rectal examination, serum acid phosphatase, bone scan and pelvic computerized tomography scan) by transrectal sonography before radical prostatectomy. of the 48 patients with histologically proved localized prostate cancer sonography overstaged the disease in 5 (10%) and correctly staged it in 43 (90%). all overstaged cancer patients were scanned after either prostatic biopsy (4) or transurethral prostatectomy (1 ... | 2009 | 2681836 |
| a sonographic and karyotypic study of second-trimester fetal choroid plexus cysts. | a prospective study was undertaken of 513 women between 15.6-24.1 weeks' gestation who had a level ii ultrasound examination followed immediately by a genetic amniocentesis. the presence or absence of fetal choroid plexus cysts was noted and the results correlated with the fetal karyotype. thirteen cases of choroid plexus cysts were observed sonographically, a prevalence of 2.5%. the size of the cysts ranged from 3-10 mm, with a median of 6 mm. there were no other sonographically detectable cong ... | 2009 | 2649818 |
| problems associated with the use of immediately dangerous to life and health (idlh) values for estimating the hazard of accidental chemical releases. | the possibility of accidental industrial chemical releases has generated considerable recent attention. one area requiring research for emergency planning is the development of safe exposure concentrations for the public in the event of an inadvertent release. the united states environmental protection agency (epa) has established a list of extremely hazardous substances and suggested that the toxicity ranking for 92 hazardous materials could be based on the "immediately dangerous to life or hea ... | 2009 | 2688389 |
| [intraoperative management of emergency coronary artery bypass grafting]. | intraoperative hemodynamics during emergency coronary artery bypass grafting (cabg) for acute evolving myocardial infarction (26 cases) were measured and compared with those during elective cabg (39 cases). before cardiopulmonary bypass period, it was strongly suggested that the cardiac function of emergency cases was worse than that of elective cases because of the following 5 factors; (1) hypotension, (2) tachycardia, (3) low stroke volume index, (4) pulmonary congestion and (5) metabolic acid ... | 2009 | 2786576 |
| cognitive and social-emotional development of children in different preschool environments. | 62 english-speaking preschool children were divided into three groups, a montessori group (n = 21), a traditional preschool group (n = 21), and a homestaying group (n = 20) to compare their relative cognitive and social-emotional development. significant differences in favour of the school groups were found for vocabulary, language comprehension, ability to judge the correctness of figural stimuli, visual memory, and perceptual organization. no differences were found for social-emotional develop ... | 2009 | 2798666 |
| cognitive and social-emotional development of children in different preschool environments. | 62 english-speaking preschool children were divided into three groups, a montessori group (n = 21), a traditional preschool group (n = 21), and a homestaying group (n = 20) to compare their relative cognitive and social-emotional development. significant differences in favour of the school groups were found for vocabulary, language comprehension, ability to judge the correctness of figural stimuli, visual memory, and perceptual organization. no differences were found for social-emotional develop ... | 2009 | 2798666 |
| [characteristics of the course of the gestation period in patients with solitary kidney]. | clinical biochemical, bacteriological investigations and functional tests were performed in 37 pregnant females with a solitary kidney. the status of fetoplacental system was studied as well. the investigators noted such common complications of pregnancy as the aggravation of renal inflammation, a high rate of caesarean section and postnatal morbidity. it was concluded that in case of pyelonephritic affection a solitary kidney the pregnancy should be terminated. if the infection was absent and t ... | 2009 | 2817278 |
| near-miss asphyxiation from a toy ball: a small parts failure. | the case report of a near-fatal asphyxiation of an 11-month-old child by a 26 mm (diameter) toy ball is presented. the lack of compliance with existing consumer product safety commission standards for small parts is discussed, and a recommendation is made regarding the coloring of ingestible objects. | 2009 | 2710666 |
| [coagulation and fibrinolytic system of macrophages]. | 2009 | 2786578 | |
| [sudden death of a young adult and right ventricular cardiomyopathy]. | 2009 | 3207241 | |
| management of acute asthma. | 2009 | 2713796 | |
| structure-activity study of the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced neurotoxicity. ii. evaluation of the biological activity of the pyridinium metabolites formed from the monoamine oxidase-catalyzed oxidation of mptp analogs. | in the accompanying paper, several tetrahydropyridine analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) were screened for their abilities to be oxidized by monoamine oxidase (mao) to pyridiniums and to produce neurotoxicity in mice. we reported that most of the analogs were oxidized by mao to pyridiniums and some of the analogs were neurotoxic. we concluded that the capacity of a tetrahydropyridine mptp analog to be oxidized by mao to a pyridinium was a necessary, but not sufficient ... | 2009 | 2786565 |
| dislocated jaw. | 2009 | 2742562 | |
| who issues report on heavy metal and pah compounds from municipal incinerators. | 2009 | 2754439 | |
| intraoperative staging in ovarian cancer. | in patients with early stage i or ii ovarian cancer a meticulous staging laparotomy is required; this should include omentectomy, pelvic and paraaortic lymphadenectomy, multiple peritoneal biopsies and diaphragmatic biopsies. adjunctive therapy is based on these surgical-pathological findings. in patients with advanced disease (stages iii and iv) it has been demonstrated that optimal tumour reduction enhances the length of survival. a complete resection of all gross disease in the abdominal cavi ... | 2009 | 2661086 |
| [the importance of physiopathology in the management of peptic ulcer]. | 2009 | 2772478 | |
| [diagnosis and treatment of neuroblastoma in children--analysis of 98 patients]. | from 1959 to 1982, 98 patients with neuroblastoma were treated in our hospital. seventy-eight were diagnosed by pathology and 69 (88.5%) were followed for 1 approximately 18 years. 50(51%) had already had distant metastasis (22, to bone) on admission. operation was performed on 53 patients (total excision on 18, partial excision on 11 and biopsy on 24 patients). the 1 and 15 year survival rates were 31.4% and 12.9%. the survival curve levelled off from the second year of the operation and remain ... | 2009 | 3769741 |
| a ruptured cerebral aneurysm from choriocarcinomatous origin--a case report and a review. | a case of a ruptured metastatic aneurysm of choriocarcinoma is reported. the fourteen other cases of the literature are summarized. the pathological significance of this rare presentation of metastatic disease is discussed. the treatment of choice is defined as excision followed by chemotherapy and whole brain irradiation. the prognosis remains poor. | 2009 | 2747937 |
| [osteolytic foci: cancer or not?]. | 2009 | 2797229 | |
| species differences in the pharmacology of terminal 5-ht autoreceptors in mammalian brain. | 2009 | 2665245 | |
| [nursing career development program by private industry--from job management to career management]. | 2009 | 2615507 | |
| [cataract surgery 220 years ago]. | the author reports on the first 14 cataract extractions performed by karl kaspar von siebold, a würzburg surgeon, in 1766/67. he used daviel's method. at that time there was no anesthesia, no sterility or even antisepsis, and no optical correction of aphakia for his patients. four eyes were lost due to infection and another four had much poorer vision after surgery due to irregular corneal scarring. in six cases both patient and physician were satisfied with the result. siebold's case reports ex ... | 2009 | 2689768 |
| fibrinogen nagoya, a replacement of glutamine-329 by arginine in the gamma-chain that impairs the polymerization of fibrin monomer. | structural studies on a hereditary abnormal fibrinogen, fibrinogen nagoya (takamatsu, j., ogata, k., kamiya, t., koie, k., takagi, t., & iwanaga, s. (1979) thromb. haemost. 42, 78), were performed to identify the abnormality responsible for the impaired polymerization of fibrin monomer. upon sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing conditions, fibrinogen nagoya showed the presence of an extra protein band with an apparent molecular weight of 49,500 in addition to ... | 2009 | 2738036 |
| [dynamics of bile secretion under stressful conditions]. | 2009 | 2702266 | |
| levels and sources of stress in medical students. | levels of stress, as measured by the general health questionnaire, were assessed in 318 medical students in their fourth year at three british universities. mean scores were higher than those in other groups within the general population, and the estimated prevalence of emotional disturbance was 31.2%, a proportion similar to that reported in medical students in the united states. there were no differences in prevalence or in mean scores of stress between the sexes. twelve (4%) students reported ... | 2009 | 3085772 |
| bcl-2 regulates the onset of shiga toxin 1-induced apoptosis in thp-1 cells. | shiga toxins (stxs), which are proteins expressed by the enteric pathogens shigella dysenteriae serotype 1 and some serotypes of escherichia coli, are potent protein synthesis inhibitors. stx-producing organisms cause bloody diarrhea with the potential to progress to acute renal failure and central nervous system complications. studies using animal models of these diseases have shown that stxs are major virulence factors, and purified toxins have been shown to be capable of killing many types of ... | 2009 | 19752028 |
| the shigella dysenteriae serotype 1 proteome, profiled in the host intestinal environment, reveals major metabolic modifications and increased expression of invasive proteins. | shigella dysenteriae serotype 1 (sd1) causes the most severe form of epidemic bacillary dysentery. we present the first comprehensive proteome analysis of this pathogen, profiling proteins from bacteria cultured in vitro and bacterial isolates from the large bowel of infected gnotobiotic piglets (in vivo). overall, 1061 distinct gene products were identified. differential display analysis revealed that sd1 cells switched to an anaerobic energy metabolism in vivo. high in vivo abundances of amino ... | 2009 | 19813213 |