Publications

somatostatin receptor incidence and distribution in breast cancer using receptor autoradiography: relationship to egf receptors.	somatostatin receptors (ss-r) were measured with in vitro receptor autoradiography using the ss analog 125i-[tyr3]-sms 201-995 as radioligand in 342 breast-tumor samples. in a group of 158 "small" tumor samples (mean section surface: 14 mm2 +/- 0.4; mean +/- sem), 34 tumors (21%) were ss-r positive. in a group of 72 "large" tumor samples (mean size: 180 mm2 +/- 8; mean +/- sem), 33 tumors (46%) were ss-r positive. in this second group, more than half of the tumors had a non-homogeneous distribut ...	2007	2168344
[the importance of shigella boydii in shigellosis morbidity in the ussr].	the etiological role of s. boydii in shigella infections registered at different territories of the ussr in 1986-1987 was analyzed. as established by this analysis, s. boydii infection occurred mainly at the territories with unsatisfactory water supply of the population; from these territories the infection spread to ther territories of the ussr. the dominating serovars causing s. boydii dysentery, as well as shigella infections, at different territories of the ussr was shown to be identical, wh ...	1990	2195811
polymerase chain reaction for detection of invasive shigella flexneri in food.	the polymerase chain reaction (pcr) was used to amplify a 760-base-pair (bp) fragment with the 220-kbp invasive plasmids of enteroinvasive escherichia coli, shigella flexneri, shigella dysenteriae, shigella boydii, and shigella sonnei as templates. this pcr product was easily detected by agarose gel electrophoresis. a 210-bp acci-psti fragment lying within the amplified region was used as a probe in southern hybridization blots and showed that the pcr-generated product was derived from the invas ...	1990	2200336
plasmid profile analysis and antimicrobial susceptibility patterns of shigella isolates from nigeria.	in an epidemiological survey, plasmid profiles and antimicrobial susceptibility testing of 100 shigella isolates in lagos, nigeria was done. all the isolates were sensitive to nalidixic acid, nitrofurantoin and ciprofloxacin. the commonest antimicrobial susceptibility pattern was resistance to ampicillin, colistin sulphate, co-trimoxazole, streptomycin and tetracycline. all but 4 of 100 isolates screened contained one or more plasmids. plasmid profile analysis distinguished more strains than did ...	1990	2200702
childhood shigellosis: clinical and bacteriological study.	ninety-three children with shigellosis were hospitalized in a regional hospital in kuwait during the year 1988. s. flexneri was the most common isolate (54%) followed by s. sonnei (39%) and s. boydii (7%). in addition to the gastrointestinal manifestations, 14 patients (15%) developed generalized convulsions. the benign and self-limiting nature of the convulsions associated with shigellosis means that neither diagnostic procedure nor drug therapy are usually necessary. the disease was self-limit ...	1990	2202839
age, sex, and region adjusted concentrations of chromium and nickel in lung tissue.	chromium (cr) and nickel (ni) concentrations were measured in lung tissue from 110 random necropsies by means of atomic absorption spectrometry. the subjects originated from the ruhr district (bochum (71 cases) and dortmund (16 cases) areas), which has been defined as a particular pollution area with locally high cr and ni emissions, and from münster and vicinity (23 cases). the cr and ni concentrations in lung tissue of the subjects from the ruhr district (3.09 (sd 2.99) micrograms cr/g, 0.65 ( ...	2007	2223660
age, sex, and region adjusted concentrations of chromium and nickel in lung tissue.	chromium (cr) and nickel (ni) concentrations were measured in lung tissue from 110 random necropsies by means of atomic absorption spectrometry. the subjects originated from the ruhr district (bochum (71 cases) and dortmund (16 cases) areas), which has been defined as a particular pollution area with locally high cr and ni emissions, and from münster and vicinity (23 cases). the cr and ni concentrations in lung tissue of the subjects from the ruhr district (3.09 (sd 2.99) micrograms cr/g, 0.65 ( ...	2007	2223660
the monitoring of foodhandlers in papua new guinea.	in early 1987 guidelines were re-enforced for pre-employment medicals and 6-monthly health checks on foodhandlers in the ok tedi mining project in papua new guinea. the health monitoring program was stepped up as a result of two typhoid cases imported from the highlands and catering subcontractors failing to comply with the necessary pre-placement medicals for foodhandlers. highlanders made up 28% (49/174) of the ok tedi catering department's workforce in 1987. the initial screen of 155 foodhand ...	1990	2238835
[bacillary dysentery--1988].		1990	2251385
[a new serotype of shigella boydii].	two strains which belong to the same serotype of shigella were isolated from the bloody-pus stool of two patients (in 1986) and is reported in this paper. the results were identical both showing agglutination in low titer with serotype 8 of s. dysenteriae and serotype 4 of s. boydii when the two strains were checked well with all kinds of diagnostic antisera and vice versa, ie the antisera produced by the two strains were also checked well with sera prepared with the representative strains of al ...	1990	2251827
glucocorticoid-regulated gene expression in the immune system. analysis of glucocorticoid-regulated transcripts from the mouse macrophage-like cell line p388d1.	to further elucidate the molecular mechanisms underlying glucocorticoid-mediated immune suppression, we have exploited cdna cloning and subtractive screening methods to identify glucocorticoid-regulated transcripts in the mouse macrophage-like cell line, p388d1. two of the three isolated glucocorticoid-regulated mrna species corresponded to genes potentially important to immunoregulation: one glucocorticoid-suppressed mrna species probably encoded the previously uncloned 3-hydroxy-3-methylglutar ...	1990	2258621
[bacteriology and epidemiology of shigellas isolated at the army hospital in djibouti].	in a space of 26 months 108 shigellas were isolated from 104 patients with sporadic and benign diseases. 90% of the subjects were young french. both s. dysenteriae and s. boydii make up 21% of the strains studied. 13% of the germs are multiresistance. multiresistance can enhance development of serious sickness if a virulent strain comes in.	1990	2263188
structural aspects of pathology in alzheimer's disease.	the characteristic lesions of alzheimer's disease, neurofibrillary tangles and neuritic plaques, are the sites of accumulation of abnormal fibrillar material. the structure of the paired helical filament from tangles has been analysed by electron microscopy and biochemical studies have shown that it contains microtubule associated protein tau as a component. fibrils of beta-amyloid in the neuritic plaque arise by polymerization of a small proteolytic fragment of a much larger precursor protein. ...	2008	2268679
[current views on the pathomorphology and pathogenesis of dysentery].	according to the literature and the authors' data in patients who died of dysentery shigellae are found seldom because of postmortem shedding of superficial colonic epithelium infected by them. shigella adhesion and invasion into the colonocytes are regularly found in the colon biopsies. as shown recently in experiments, shigella outer membrane proteins forming "contact haemolysin" ("virulence plasmid" product) are responsible for their invasion. in the small intestine this cytotoxin is destroye ...	1990	2281980
[study of the blink reflex in spinocerebellar degeneration].	blink reflex (br) was composed of r1 and r2. r1 is considered to indicate the brainstem function. the purpose of this study was to evaluate the brainstem function of spinocerebellar degeneration (scd) by the r1 latency (r1). br was evoked by the percutaneous stimulation of supraorbital nerve. and r1 was measured by the action potential of orbucularis oculi muscle. direct response was recorded by the percutaneous stimulation of facial nerve to determine the terminal latency of facial nerve (d). b ...	2008	2364628
kinetics of "p"-site-mediated inhibition of adenylyl cyclase and the requirements for substrate.	the kinetics of "p"-site-mediated inhibition of adenylyl cyclase was studied with the detergent-solubilized enzyme from rat brain. mn2(+)-activated adenylyl cyclase exhibited typical noncompetitive inhibition by 2'-d3'-amp or 2',5'-dideoxyadenosine (2',5'-ddado). however, enzyme that was preactivated with guanosine 5'-o-(3-thiotriphosphate) (gtp gamma s) or proteolytically with ninhibin (+ gtp gamma s) exhibited apparently uncompetitive inhibition with either 2'-d3'-amp or 2',5'-ddado and with e ...	1990	2365688
tissue integration of a12o3-ceramic dental implants (frialit)--a case report.	the tissue intraosseous integration of a12o3-ceramic dental implants (frialit) is studied in a patient case, where an implant-fracture made it necessary to remove the implant from a patient's jaw. the surgical removing of the apical part of the implant with the use of a trepan bur made it possible to examine and visualize histologically and microradiographically the tissue adjacent to the implant. the results of both the histological and microradiographical studies showed that a good healing and ...	2007	2374995
predicted conformations for the immunodominant region of the circumsporozoite protein of the human malaria parasite plasmodium falciparum.	the circumsporozoite protein of the human malaria parasite plasmodium falciparum contains multiple tandem repeats of the amino acid sequence asn-ala-asn-pro. the repeated sequence encompasses the immunodominant region of the protein, and antibodies raised against it are potent inhibitors of invasion and development of sporozoites in cultured hepatocytes. using a modified build-up procedure, we have explored a large number of possible helical and near-helical conformations of a terminally blocked ...	1986	2426702
[somatic antigens of shigella and escherichia coli. determination of the structure of o-specific polysaccharide from shigella boydii type 12 and its serological properties compared with the o-specific polysaccharide from escherichia coli].	the structure of the o-specific polysaccharide of the somatic antigen (lipopolysaccharide) of shigella boydii, type 12, was established by 1h- and 13c-nmr, methylation analysis and partial acid hydrolysis methods. the polysaccharide consists of pentasaccharide repeating units of the following structure: (formula; see text) the amount of o-acetyl groups was far less than stoichiometric, only about 2 for 3-4 repeating units. nevertheless, the results of serological studies revealed 3-o-acetyl-alph ...	1986	2430583
[intergeneric antigenic relation of hafnia and shigella (s. flexneri and s. boydii) bacteria].	the o-antigenic relationships between hafnia and shigellae (s. flexneri and s. boydii) have been studied. for the first time the presence of antigenic relationship between hafnia o19, o4, o9, o33, o5, o16, o12, o7, o29, o28, o10, o32, o24, o25, o18, o1, o13, o3, o22, o30, o37, o14, o11, o25, o23, o21, o28, o16, o24, o8, o26, o27 and s. flexneri la, lb, 2a, 2b, 4a, 4b, 6, 5a, 5b, as well as between hafnia o10, o21, o35, o36, o9, o28, o8, o30 and s. boydii 1, 3, 6, 14, 2, 5, 2, 12 have been reveal ...	1986	2431565
sporidesmin and gliotoxin induce cell detachment and perturb microfilament structure in cultured liver cells.	changes in cell morphology and cell adhesion occurred when cultured cells from the rat liver cell strain c3 were exposed to the fungal toxins, sporidesmin or gliotoxin. both toxins caused loss of attachment of the cells to the plastic of tissue culture plates and this effect was preceded by loss of actin cables. other changes included cytoplasmic vacuolation and blocked entry into s-phase of the cell cycle. under these conditions [3h]thymidine incorporation into the cells was also diminished but ...	1986	2432076
[antigenic determinants of bacteria. the structure of the repeating unit of a specific polysaccharide from shigella boydii type 7].	acid hydrolysis of the antigenic lipopolysaccharide from shigella boydii type 7 afforded a specific polysaccharide composed of 2-acetamido-2-deoxy-d-glucose, d-glucose, d-galactose, 5-acetamido-3,5,7,9-tetradeoxy-7-[(3r)-3-hydroxybutyramido]-l- glycero-l-manno-nonulosonic acid (nonn2a) and acetic acid residues in the 1:1:2:1:1 ratio. from the results of methylation analysis, hydrogen fluoride solvolysis and smith degradation, the structure of the repeating unit of the specific polysaccharide was ...	1987	2437931
a mucin containing the x, y, and h type 2 carbohydrate determinants is shed by carcinoma cells.	monoclonal antibody br 15-6a directed to the y carbohydrate determinant (fuc alpha 1----2gal beta 1----4glcnac(3----1fuc) beta 1----3gal beta 1----4glc beta 1----1cer) reacted with the cell surface and conditioned media of colorectal and breast carcinoma cell lines. double determinant immunoassays using br 15-6a as detector antibody showed that the y determinant is part of a high molecular weight mucin that coexpressed other carbohydrate antigens based on a type 2 chain (x, h type 2). type 1 cha ...	2008	2442094
influence of neuropeptides on airway smooth muscle.	the first bronchoactive (and vasoactive) peptide to be discovered in the lung was isolated and characterized in 1970 from an embryologically related organ, the small intestine. since then, more than 20 additional peptides have been described in lung tissue and their biologic activities investigated. many of these are neuropeptides acting as neurotransmitters or neuromodulators to influence airway, pulmonary vascular, and other functions. more neuropeptides are known to exist in the brain and per ...	1987	2446543
[antigenic polysaccharides of bacteria of the genus shigella. determination of the structure of polysaccharide chains of shigella boydii type 9 lipopolysaccharide and detection of unusually high molecular weight glycolipid].	specific acidic polysaccharide has been isolated from the shigella boydii type 9 antigenic lipopolysaccharide after mild hydrolysis followed by chromatography on sephadex g-50. the polysaccharide consists of d-glucose, d-glucuronic acid, 2-acetamido-2-deoxy-d-glucose, and l-rhamnose. from the results of methylation analysis, partial acid hydrolysis and 13c nmr data the structure of the repeating unit of the polysaccharide was deduced as follows: [----4)dglcp(alpha 1----4)dglcap(beta 1----3)dglcn ...	1987	2447896
[antigenic polysaccharides of bacteria of the genus shigella. the structure of the polysaccharide chain of shigella boydii type 14].	a specific acidic polysaccharide has been isolated from the shigella boydii type 14 antigenic lipopolysaccharide after mild hydrolysis followed by chromatography on sephadex g-50. the polysaccharide consists of the d-glucuronic acid, 2-acetamido-2-deoxy-d-glucose and d-galactose residues in the ratio 1:1:3. from the results of methylation analysis and partial acid hydrolysis, the structure of the repeating unit of the specific polysaccharide was deduced as follows: (-6dgalp alpha 1-4dglcap beta ...	1987	2447897
immunoglobulin m, a, and g antibody response to lipopolysaccharide o antigen in symptomatic and asymptomatic shigella infections.	the antilipopolysaccharide antibody response in sera obtained from subjects involved in 10 outbreaks of shigellosis occurring in israeli military field units was determined by an enzyme-linked immunosorbent assay and a passive hemagglutination test. both tests were found to be sensitive and specific for the diagnosis of shigellosis. a significant antibody response was detected in 73 to 82% of the symptomatic and 48 to 60% of the asymptomatic subjects during the shigella sonnei and shigella flexn ...	1989	2463995
lack of effect by prostaglandin f2 alpha and verapamil on calcium uptake by isolated corpora lutea from pseudopregnant rats.		1989	2492809
four new provisional serovars of shigella.	four bacterial strains are described that possess the biochemical characteristics of shigella species but do not belong to any of the established shigella serovars or to any previously described provisional serovar. one strain fermented mannitol, and it is proposed that this be the type strain for a new provisional serovar of shigella boydii. the remaining strains did not ferment mannitol and belonged to three different serovars. these strains are proposed as type strains for three new provision ...	1989	2501349
shigellae and vibrionaceae species as a cause of diarrhoea among children in aden.	in aden, the incidence of diarrhoea among infants and children is still high. the present work aimed at investigation of shigelleae and vibrionaceae as etiologic agents of enteric infections. stool specimens obtained from 1056 children complaining of diarrhoea were cultured on plating media and on enrichment media. suspected colonies were then serotyped and antibiotic sensitivity tests performed. seven percent of the specimens were found positive for shigella strains. shigella boydii was the com ...	1989	2519964
[a germ cell tumor of an ectopic testis in polyorchidism].		2008	2547104
structural analysis of the o-glycosidically linked core-region oligosaccharides of human meconium glycoproteins which express oncofoetal antigens.	glycoproteins were extracted from meconium samples of group o neonates of secretor type by pronase digestion followed by precipitation in 67% aqueous ethanol and separated into ii antigen enriched and depleted fractions by affinity chromatography. the latter fraction strongly expressed the oncofoetal antigens recognised by natural antibodies in mouse sera and the hybridoma antibody fc 10.2, and this activity was enhanced after mild acid hydrolysis to remove sialic acid and fucose residues. oligo ...	1985	2580706
altered queuine modification of transfer rna involved in the in vitro transformation of chinese hamster embryo cells.	altered queuine modification of trna has been correlated to neoplastic transformation, but no direct cause and effect relationship has been defined. in the present study, a potential role for this alteration has been assigned. the trna in normal chinese hamster embryo cells is significantly more queuine modified than the trna in their transformed chinese hamster embryo counterparts, even though the specific activity of the queuine modification enzyme is much lower in chinese hamster embryo cells ...	2008	2582452
high incidence of false positives by a latex agglutination test for the diagnosis of clostridium difficile associated colitis in compromised patients.	detection of clostridium difficile cytotoxin using cell culture assays for the diagnosis of antibiotic-associated colitis has been used for over a decade. because the methodology is time consuming and cumbersome, a recently introduced commercial latex agglutination (la) kit has attracted much attention. we compared the sensitivity and specificity of this method with the cytotoxic assay (cta) using diarrheal stools from 652 patients at a referral tertiary care center. specimens from 71 (10.9%) pa ...	1989	2591165
causes of death and the histopathologic findings in fatal shigellosis.	thirty-seven children (median age, 2 years) with shigellosis in bangladesh were subjected to postmortem examination to determine causes of death and the spectrum of intestinal histopathology. infecting species were: shigella dysenteriae 1, 7 cases; s. dysenteriae 2, 2 cases; shigella flexneri, 23 cases; shigella boydii, 4 cases; and mixed infection with shigella boydii and shigella sonnei, 1 case. complicating conditions detected before death included malnutrition in 25 cases, pneumonia in 11 ca ...	1989	2594452
cadmium and lead accumulation by goldfish exposed to aqueous refuse incinerator fly ash leachate.		2008	2597788
bacterial pathogens isolated from cockroaches trapped from paediatric wards in peninsular malaysia.	a survey was conducted in 4 paediatric wards in malaysia to determine the distribution of various species of cockroaches and to examine their gut contents for bacteria. cockroaches were trapped from food dispensing areas (kitchens), store rooms, cupboards and open wards. 104 cockroaches were caught, consisting of periplaneta americana (67.3%), blattella germanica (26%), p. brunnea (4.8%), and supella longipalpa (1.9%). bacteria were isolated from all cockroaches except 3 p. americana. many bacte ...	1989	2603192
cardiopulmonary baroreflex control of brachial artery diameter in sustained essential hypertension.	an exaggerated reflex response of forearm resistance vessels following stimulation of cardiac mechanoreceptors has been observed in human hypertension. in the present study we analyze the possibility that such an increased response also involves the large brachial artery. for that purpose, the influence of leg elevation in subjects in a supine position on brachial artery diameter and blood flow velocity was studied in 12 healthy, normal males and 17 males of the same age with sustained essential ...	1989	2607141
autosomal dominant retinitis pigmentosa (adrp): localization of an adrp gene to the long arm of chromosome 3.	members of a large pedigree of irish origin presenting with early onset type i autosomal dominant retinitis pigmentosa (adrp) have been typed for d3s47 (c17), a polymorphic marker from the long arm of chromosome 3. significant, tight linkage of adrp to d3s47, with a lod score of 14.7 maximizing at 0.00 recombination, has been obtained, hence localizing the adrp gene (rp1) segregating in this pedigree to 3q.	1989	2613244
membrane current responses of skate photoreceptors.	light-evoked membrane currents were recorded with suction electrodes from the outer segments of individual photoreceptors enzymatically dissociated from the skate retina. the intensity-response relation of dark-adapted cells closely followed a michaelis function for which a half-saturating response was elicited by a flash intensity that produced about 36 photoisomerizations. dim-light responses, as well as the early rising phase of the responses to a wide range of flash intensities, could be des ...	2008	2614369
indomethacin blocks the anorexic action of interleukin-1.	it has been reported recently that the central nervous system actions of interleukin-1 are mediated by the prostaglandin system in the brain. the present study was therefore performed in order to examine the hypothesis that indomethacin, an inhibitor of prostaglandin biosynthesis, might alleviate the interleukin-1-induced suppression of food intake in rats. the i.p. injection of interleukin-1 (2 micrograms/rat) resulted in a significant decrease in food intake. the pre-injection of indomethacin ...	1989	2620696
indomethacin blocks the anorexic action of interleukin-1.	it has been reported recently that the central nervous system actions of interleukin-1 are mediated by the prostaglandin system in the brain. the present study was therefore performed in order to examine the hypothesis that indomethacin, an inhibitor of prostaglandin biosynthesis, might alleviate the interleukin-1-induced suppression of food intake in rats. the i.p. injection of interleukin-1 (2 micrograms/rat) resulted in a significant decrease in food intake. the pre-injection of indomethacin ...	1989	2620696
the effects of acetyl-l-carnitine on experimental models of learning and memory deficits in the old rat.	experimental models of learning and memory deficits in aged rats can be studied by means of behavioural tests that provide an important tool for evaluating the effect of drugs on these parameters. active and passive avoidance tests showed a clear impairment of learning and memory capacity of old rats. these tests were also used to study the behavioural effect of acetyl-l-carnitine in aged rats. the subchronic treatment with this drug was followed by a significant improvement of acquisition and r ...	1989	2620857
the effects of acetyl-l-carnitine on experimental models of learning and memory deficits in the old rat.	experimental models of learning and memory deficits in aged rats can be studied by means of behavioural tests that provide an important tool for evaluating the effect of drugs on these parameters. active and passive avoidance tests showed a clear impairment of learning and memory capacity of old rats. these tests were also used to study the behavioural effect of acetyl-l-carnitine in aged rats. the subchronic treatment with this drug was followed by a significant improvement of acquisition and r ...	1989	2620857
isolated and combined deficiencies of the alpha-keto acid dehydrogenase complexes.		1989	2634350
[clinical-experimental examinations on phonetic function in edentulous patients and after insertion of total prostheses measured by the s-sound realization].	lose of teeth and therapy by prosthesis interfering with the oral sectors that are necessary for s-sound articulation have an important influence on s-sound realization. hitherto, the resulting s-sound changes used to be evaluated only from a subjective point of view. the application of a complex measuring technique for s-sound analysis permitted to determine the influence of the upper and lower jaw plates on s-sound formation by experiments. in another series of experiments, it was shown that e ...	2008	2640388
bilateral torsion of the normal ovary and oviduct in a young girl.		2008	2643670
bilateral torsion of the normal ovary and oviduct in a young girl.		2008	2643670
surgical history. evolution of the stoma.	the evolution of the procedures for the formation of a surgical abdominal stoma are outlined; this was first, intestinal exteriorization for trauma, then stoma formation alone and finally stoma formation associated with bowel resection. accounts and recommendations occurred in the 16th and 17th centuries as by pillore and duret, but were few in number. development of the stoma on a sound basis did not occur until the late 19th century. dupuytren, bryant, maydl, mikulicz von radecki and miles wer ...	2008	2643941
emergence of highly trimethoprim-sulfamethoxazole-resistant shigella in a native american population: an epidemiologic study.	resistance to trimethoprim-sulfamethoxazole (tmp-smx) emerged among shigella isolates from the navajo reservation in the southwestern united states in 1985, years after this antimicrobial agent came into common use. in the study area, tmp-smx resistance increased dramatically from 3 per cent in 1983 to 21 per cent in 1985. resistance was polyclonal and occurred in both s. sonnei and s. flexneri. no single plasmid was common to all resistant strains. however, all 28 tmp-smx resistant isolates exa ...	1989	2650535
lead toxicity and iron deficiency in utah migrant children.	we determined the frequency of presumptive iron deficiency and lead toxicity in 198 utah migrant children, ages 9-72 months, during the summer of 1985. there were no confirmed cases of lead toxicity. thirteen per cent of those tested and 30 per cent of the children ages 9-23 months were iron deficient. hematocrit determinations accurately predicted iron deficiency in only 35 per cent of the children confirmed to have this disorder via erythrocyte protoporphyrin screening.	2009	2650572
bacterial hydrophobicity, an overall parameter for the measurement of adhesion potential to soil particles.	the adhesion of salmonella typhimurium to the mineral particles quartz, albite, feldspar, and magnetite was shown to correlate with the hydrophobicity of the cell surface as measured by hydrophobic interaction chromatography. the same effects were also seen for seven other selected test strains, including streptococcus faecalis, streptococcus faecium, escherichia coli, citrobacter freundii, shigella sonnei, and shigella boydii. when the test strain of salmonella typhimurium, was repeatedly culti ...	1989	2650618
[anxiety and the presence of the father at childbirth].	the authors give a report of a follow-up the anxiety of 363 couples whereby the husband decided to be present at the childbirth and took part in the childbirth preparation courses. the anxiety state and anxiety trait in men was found to be significantly lower than in women. the data of women were compared to a matched control group consisting of 135 pregnant women. in cases where the husband was present at childbirth the anxiety state and anxiety trait of the women was considerably lower than in ...	2007	2652033
[isolation of shigella boydii serotype 14 with altered biochemical characteristics in a water-borne epidemic of dysentery].	two water-borne epidemics of bacillary dysentery have been described in a garrison in which the leading causative agent has been shigella boydii, serotype of 14 altered biochemical characteristics isolated for the first time in yugoslavia. all the isolated strains of this shigella were mannitol negative and they degradated gylocose to acidity and gas already after 24 hours, and arabinose and sorbitol to acidity and gas after 48 hours. the clinical picture of the diseased was characteristic of ba ...	1989	2662591
review of cardiovascular findings in humans treated with minoxidil.	minoxidil is an antihypertensive vasodilator with no known capability of inducing human cardiovascular pathology; however, the compound does cause a late, canine-specific lesion of the right atrium and acute right atrial and ventricular papillary muscle changes. in all the autopsy cases of minoxidil-treated humans to date, 9 cases were reported with significant right atrial or other cardiac pathology and were carefully reviewed for similarity to either the early or late canine lesion. three new ...	1989	2665032
the secret of medical management.	a review of the research on group practices punctures the myth of physician autonomy in hospitals and opens the way for administrators to join in controlling the patient care process.	2009	2670836
[insulin and glucocorticoid binding by blood cell receptors after hydrocortisone administration in rabbits].	repeated i.v. administration of hydrocortisone (10 mg/kg) revealed an increase in the resistance against insulin although endogenous corticosterone was decreased in 33 male rabbits. the insulin- and dexamethasone-binding receptors of erythrocytes and mononuclear leucocytes. changed after 3-7 hydrocortisone injections, the binding increasing for insulin and diminishing for dexamethasone.	1989	2680632
[ultrasonic tissue characterization of parotid tumors--analysis with the acoustic microscope].	the purpose of this study was to investigate acoustic properties of parotid tumors in detail by using the mechanically scanned acoustic microscope. the frequency of ultrasound was fixed at 200mhz. the amplitude images and the phase contrast images were taken in pictures. mean attenuation, mean velocity, microscopic variation of the attenuation and that of the sound velocity were also measured and analyzed. the results are summarized as follows: 1) the acoustic properties of the tissue were optic ...	2009	2681618
regulation of plasminogen activators and their inhibitors in rheumatic diseases: new understanding and the potential for new directions.	over the past several years there has been a rapid expansion in our understanding of the fibrinolytic system. this includes knowledge of the components, availability of recombinant reagents and a better understanding of the regulation of fibrinolysis in health and disease. disturbances in the regulation of the balance between fibrin deposition and removal have been implicated in a number of inflammatory diseases including certain rheumatic diseases. this overview summarizes our knowledge of the ...	2009	2681762
sonographic and pathological staging of patients with clinically localized prostate cancer.	we evaluated 64 patients with clinically localized prostate cancer (on the basis of rectal examination, serum acid phosphatase, bone scan and pelvic computerized tomography scan) by transrectal sonography before radical prostatectomy. of the 48 patients with histologically proved localized prostate cancer sonography overstaged the disease in 5 (10%) and correctly staged it in 43 (90%). all overstaged cancer patients were scanned after either prostatic biopsy (4) or transurethral prostatectomy (1 ...	2009	2681836
recent advances in gastrointestinal malignancy.		2008	2686527
recent advances in gastrointestinal malignancy.		2008	2686527
[cataract surgery 220 years ago].	the author reports on the first 14 cataract extractions performed by karl kaspar von siebold, a würzburg surgeon, in 1766/67. he used daviel's method. at that time there was no anesthesia, no sterility or even antisepsis, and no optical correction of aphakia for his patients. four eyes were lost due to infection and another four had much poorer vision after surgery due to irregular corneal scarring. in six cases both patient and physician were satisfied with the result. siebold's case reports ex ...	2009	2689768
falciparum malaria--present day problems. an experience with 425 cases.	clinical details and present day problems encountered in 425 cases of falciparum malaria (pf) are reported. 10.11% had taken chloroquine prior to reporting to us. parasitic count done in 23.05% cases lacked correlation with severity of disease. pattern of fever varied markedly but 5.4% were afebrile throughout and presented only with bodyache and malaise. apyrexial spell was noted in 5.64%. 28.70% had typical facial looks of anaemia and sallow complexion. cerebral symptoms were noted in 3.05%. o ...	1989	2693436
[the etiological structure of shigellosis in the ussr in recent years].	the characterization of etiological structure of shigella infection in the whole of the ussr, in individual union republics and at a number of other administrative territories of the ussr in recent years is presented. s. flexneri has been shown to prevail at the territories with unsatisfactory water supply of the population, and s. sonnei prevails at the territories with good water supply. at the former territories s. dysenteriae and s. boydii retain their etiological importance, while at the la ...	1989	2698030
pulsatile flow changes in the anterior cerebral arteries in infants with patent ductus arteriosus: measured with doppler technique.	cerebral hemodynamics were measured, using the doppler ultrasound technique (directed toward anterior cerebral artery through the anterior fontanel), in 6 patent ductus arteriosus (pda) patients with large left to right shunt and in 32 neonates before and just following functional closure of ductus arteriosus. pda was confirmed by color echocardiogram and doppler flow study. all 6 sick babies had prominent retrograde flow in the descending aorta during diastole. the value of pulsatility index (p ...	2009	2700277
animals released.		2009	2725649
primary structure and expression from complementary dna of skeletal muscle ryanodine receptor.	the sequence of 5,037 amino acids composing the ryanodine receptor from rabbit skeletal muscle sarcoplasmic reticulum has been deduced by cloning and sequencing the complementary dna. the predicted structure suggests that the calcium release channel activity resides in the c-terminal region of the receptor molecule, whereas the remaining portion constitutes the 'foot' structure spanning the junctional gap between the sarcoplasmic reticulum and the transverse tubule.	1989	2725677
genotypes and adhd.		2009	2738016
terminal field of cholecystokinin-8-like immunoreactive projection neurons of the rat main olfactory bulb.	the terminal field of cholecystokinin-8 (cck)-like immunoreactive (cck-ir) tufted cells in the rat main olfactory bulb was examined by means of immunohistochemistry combined with either an anterograde tracer or a degeneration method. cck immunostaining was carried out in animals in which phaseolus vulgaris agglutinin (pha) had been injected into the main olfactory bulb. pairs of adjacent sections were processed for cck and pha immunostaining, respectively. dense cck-ir terminallike staining was ...	1989	2754048
car radiator burns: a report on 72 cases.	seventy-two cases of car radiator burns (crb) were treated in the burns unit, hamad medical corporation, doha, qatar, over a 6-year period (1982-87). all the patients were males and most were between 20 and 40 years old. chest wall, face and right upper limb were the commonest sites involved. most of the patients suffered from relatively minor scalds. the scenario of the accidents as well as the topography of the burned areas were characteristic to this particular type of injury. the exceptional ...	2009	2765150
determination of estradiol 2- and 16-alpha-hydroxylase activities in mcf-7 human breast cancer cells in culture using radiometric analysis.	using a radiometric assay the effects of estradiol upon the activity of estradiol 2- and 16 alpha-hydroxylases in mcf-7 human breast cancer cells in culture were studied. after 5 days of treatment and 36 h of withdrawal, incubation in the presence of either 2- or 16 alpha-tritiated substrate was carried out. estradiol (10 nm) significantly increased 16 alpha-hydroxylase activity (21%, p less than 0.01), while no effects on 2-hydroxylase activity was observed. treatment for 6 weeks caused a major ...	1989	2770303
opening remarks of president fernando e. agrait on the occasion of the 50th anniversary of the cayo santiago macaque colony.		1989	2780954
results of the flow cytometry actg quality control program: analysis and findings.	the aids clinical trial group's (actg) immunology committee was charged with initiating a quality control program for all laboratories participating in the actg program reporting flow cytometry data. forty-one laboratories were evaluated. this report defines the goals of this program and the subsequent findings after 19 send-outs were made. both hiv positive volunteer donors and normal age-matched donors were used. sample sets included both heparin and edta anticoagulated bloods. laboratories we ...	1989	2785890
structure-activity study of the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced neurotoxicity. ii. evaluation of the biological activity of the pyridinium metabolites formed from the monoamine oxidase-catalyzed oxidation of mptp analogs.	in the accompanying paper, several tetrahydropyridine analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) were screened for their abilities to be oxidized by monoamine oxidase (mao) to pyridiniums and to produce neurotoxicity in mice. we reported that most of the analogs were oxidized by mao to pyridiniums and some of the analogs were neurotoxic. we concluded that the capacity of a tetrahydropyridine mptp analog to be oxidized by mao to a pyridinium was a necessary, but not sufficient ...	2009	2786565
[coagulation and fibrinolytic system of macrophages].		2009	2786578
[clinical significance of the quantification of obesity. the quetelet index and its use].	the degree of obesity, ie. the quantity of excessive stored adipose tissue, affects substantially morbidity and mortality on cardiovascular, metabolic, and other diseases. while the quantity of an adipose tissue is practically impossible to determine, it is necessary to use the body weight, adjusted for the stature. the quetelet's index (body mass index, bmi) is the best one from height-weight indices. values of bmi define categories of normal weight, overweight, and obesity, which have differen ...	2009	2790909
[effects of clopheline on impulse activity of neurons in the midbrain and dorsal horn of the spinal cord].	clophelin (1-5 mg/kg) suppresses spinal dorsal horn neuronal nociceptive responses but does not change their touch stimuli reactions in unanesthetized curarized cats. this effect is steady to naloxone (1 mg/kg), yohimbine (5 mg/kg) and removal by prazosin (1 mg/kg). clophelin depresses nociceptive responses of the central gray matter neurones which generalized pain impulses in the supraspinal structures.	1989	2804325
[effects of clopheline on impulse activity of neurons in the midbrain and dorsal horn of the spinal cord].	clophelin (1-5 mg/kg) suppresses spinal dorsal horn neuronal nociceptive responses but does not change their touch stimuli reactions in unanesthetized curarized cats. this effect is steady to naloxone (1 mg/kg), yohimbine (5 mg/kg) and removal by prazosin (1 mg/kg). clophelin depresses nociceptive responses of the central gray matter neurones which generalized pain impulses in the supraspinal structures.	1989	2804325
carbohydrate structures of nonspecific cross-reacting antigen-2, a glycoprotein purified from meconium as an antigen cross-reacting with anticarcinoembryonic antigen antibody. occurrence of complex-type sugar chains with the gal beta 1----3glcnac beta 1----3gal beta 1----4glcnac beta 1----outer chains.	nonspecific cross-reacting antigen-2 (nca-2) is a glycoprotein purified from meconium as a closely correlated entity with carcinoembryonic antigen (cea). as in the case of cea, only asparagine-linked sugar chains are included in nca-2. in order to elucidate the structural characteristics of the sugar chains of nca-2, they were quantitatively released from the polypeptide backbone by hydrazinolysis and reduced with nab3h4 after n-acetylation. the radioactive oligosaccharides were fractionated by ...	2010	2808357
emergence of drawing devices for total and partial occlusion: a longitudinal study.	the developmental emergence of two drawing devices was investigated in young children: the use of omission (ie not drawing any of a hidden object) to depict total occlusion and the use of hidden line elimination (hle, ie deleting only that part of an object that is hidden from view) to depict partial occlusion in a three-dimensional scene. three groups of school children (5, 6, and 7 years old) were tested individually with two tasks four times over a 2-year period. one task called for the omiss ...	2009	2813021
emergence of drawing devices for total and partial occlusion: a longitudinal study.	the developmental emergence of two drawing devices was investigated in young children: the use of omission (ie not drawing any of a hidden object) to depict total occlusion and the use of hidden line elimination (hle, ie deleting only that part of an object that is hidden from view) to depict partial occlusion in a three-dimensional scene. three groups of school children (5, 6, and 7 years old) were tested individually with two tasks four times over a 2-year period. one task called for the omiss ...	2009	2813021
genetic comparison of lav-related isolates.	lav/htlv-iii has been found to be the etiological cause of aids. this new human retrovirus has a selective tropism for t lymphocytes of the okt4/leu 3 subset, in which it induces a cytopathic effect. we have compared southern blot patterns of integrated proviral dnas from different individuals at risk or not using a nick-translated lav probe. we find that lav/htlv-iii is very similar to our haitian isolate and close to an isolate from an early-recognized (in 1982) aids case in new york. more var ...	1987	2826003
genetic comparison of lav-related isolates.	lav/htlv-iii has been found to be the etiological cause of aids. this new human retrovirus has a selective tropism for t lymphocytes of the okt4/leu 3 subset, in which it induces a cytopathic effect. we have compared southern blot patterns of integrated proviral dnas from different individuals at risk or not using a nick-translated lav probe. we find that lav/htlv-iii is very similar to our haitian isolate and close to an isolate from an early-recognized (in 1982) aids case in new york. more var ...	1987	2826003
three distinct forms of type 2a protein phosphatase in human erythrocyte cytosol.	two type 2a protein phosphatases, phosphatases i (mr = 180,000) and iii (mr = 177,000), were purified to near homogeneity from human erythrocyte cytosol. phosphatase i was composed of alpha (34 kda), beta (63 kda), and delta (74 kda) subunits in a ratio of 1:1:1. phosphatase iii comprised alpha, beta, and gamma (53 kda) subunits in the same ratio. heparin-sepharose column chromatography converted most of phosphatase i and 20% of phosphatase iii into alpha 1 beta 1 which were indistinguishable fr ...	1988	2831201
distribution and diversity of hsd genes in escherichia coli and other enteric bacteria.	we screened salmonella typhimurium, citrobacter freundii, klebsiella pneumoniae, shigella boydii, and many isolates of escherichia coli for dna sequences homologous to those encoding each of two unrelated type i restriction and modification systems (ecok and ecoa). both k- and a-related hsd genes were identified, but never both in the same strain. s. typhimurium encodes three restriction and modification systems, but its dna hybridized only to the k-specific probe which we know to identify the s ...	1988	2832380
study of plasmid screening amongst pathogenic bacteria isolated in nigeria.	clinical isolates of neisseria gonorrhoeae, campylobacter jejuni, escherichia coli, shigella dysenteriae, shigella boydii, yersinia spp. and salmonella spp. were screened for the presence of plasmids. approximately 80% of these strains harboured plasmids ranging in molecular weight from 1.0 to 45 x 10(6) daltons.	1988	2845756
neuron-specific enolase in the diagnosis of small-cell lung cancer with pleural effusion: a negative report.	we measured the concentration of neuron-specific enolase (nse) and carcinoembryonic antigen (cea) in the serum and pleural fluid of 53 patients with pleural effusions, including seven patients with small-cell lung cancer (sclc). high levels (above 12.5 micrograms.l-1) of nse in pleural fluid were observed in five patients with sclc (sensitivity 71%). however, pleural fluid nse levels were also increased in five patients with other types of cancer and in four patients with non-malignant inflammat ...	2010	2853080
new findings in anxiety. a synthesis for clinical practice in 1985.	antidepressant therapy for panic attacks, exposure therapy for stimulus-dependent anxieties, and, to a lesser extent, clomipramine therapy for obsessive-compulsive symptoms have transformed the treatment of anxiety disorders and ushered in an era of rapid progress in research on anxiety and anxiety disorders. in most cases, these symptomatic treatments should be recommended first. after these approaches have produced maximal benefit, other treatments can be considered if indicated.	2009	2859578
post-translational processing of anglerfish islet somatostatin precursors.	two distinct somatostatin precursors are synthesized in anglerfish (af) islets. in addition to a precursor which has somatostatin 14 (ss-14) as a c-terminal cleavage product, a precursor which contains at its c-terminus [tyr7, gly10] ss-14 as a potential cleavage product is also synthesized. however, even though an arg-lys pair is located immediately n-terminal to ala1 of the c-terminal tetradecapeptide, [tyr7, gly10]ss-14 was not found in significant amounts in extracts of af islets. instead, a ...	2010	2863927
immunocytochemical studies of somatostatin neurons in brain.	immunohistochemical studies with antisera to somatostatin have, in many instances, led the way to our present understanding of the peptidergic nervous system. somatostatin was among the first of the hypophysiotropic hormones shown to be contained in diverse neuronal circuits outside of the hypothalamus. for example, somatostatin is found within neurons ranging in location from the cerebral cortex to primary sensory neurons to enteric neurons within the gut wall. somatostatin was also the first n ...	1985	2863929
[the role of the nurse in starting beta-blocker therapy].		2009	2865817
blood coagulability and viper envenomation.		2010	2869321
excitatory amino acid transmitters in neuronal circuits of the cat visual cortex.	to test a possibility that glutamate (glu) and aspartate (asp) are transmitters in the visual cortex and to locate their operating sites in the cortical circuitry, we studied effects of microiontophoretic application of glu/asp antagonists on visual responses of cortical neurons in the cat. the antagonists tested were kynurenic acid (kyna), cis-2,3-piperidine dicarboxylic acid, and gamma-d-glutamylglycine. among these antagonists, kyna was most effective in blocking visual responses of cortical ...	1986	2870137
integrating treatments in schizophrenia.	schizophrenia is a common and severe illness found throughout the world. onset is usually in adolescence and young adulthood, and many individuals have illness-related impairments for life. schizophrenia assaults the very essence of what is distinctly human. the personality is devastated, subjective experience and thought distorted, and the psychological building blocks of everyday life torn asunder. this article discusses diagnostic and conceptual considerations, pharmacotherapy, and interperso ...	1986	2870478
exposure to benzodiazepines in utero.		2010	2884529
pancreatic apudomas.		2006	2885951
congenital adrenal hyperplasia.		2010	2887945
studies on the effects of pharmacological agents on antigen-induced arthritis in balb/c mice.	the model of antigen-induced monoarticular arthritis in balb/c mice, originally described by brackertz et al. (1), has been examined with regard to disease pathogenesis and the activities of established antirheumatic agents. the acute phase of the arthritis, up to 7 days after intra-articular (ia) challenge, was characterized by intense polymorphonuclear leukocyte infiltration into the challenged joint, synovial lining cell hypertrophy and hyperplasia, accumulation of mononuclear cells within th ...	2010	2890505
relationship of free intracellular calcium to the cytolytic activity of entamoeba histolytica.	entamoeba histolytica adherence and destruction of host cells is required for in vivo pathogenicity; amebic in vitro adherence is mediated by a galactose- or n-acetyl-d-galactosamine-inhibitable surface lectin (gal/galnac adherence lectin). free intracellular ca2+ concentration [( ca2+]i) was measured in living amebae and target cells during amebic cytolysis of chinese hamster ovary (cho) cells and human polymorphonuclear neutrophils by utilizing the ca2+ probe fura-2 and computer-enhanced digit ...	1988	2897335