| echocardiographic manifestation of flail right and noncoronary aortic valve leaflets. | echocardiographic studies provide information useful in determining the etiology and location of aortic valvular lesions, but assessment of their severity remains difficult. we report the findings in two patients with surgically confirmed right (case 1) and noncoronary (case 2) flail aortic leaflets in whom dense echoes filled the aortic root in systole, only to move from this position into the left ventricular outflow tract during diastole. this echocardiographic finding is a clinically useful ... | 1978 | 357098 |
| direct-plate serological grouping of beta-hemolytic streptococci from primary isolation plates with the phadebact streptococcus test. | the grouping of beta-hemolytic streptococcal isolates by a new direct-plate procedure employing phadebact streptococcus test reagents was compared with the results obtained with the 4- and 24-h phadebact grouping procedure and with the lancefield grouping obtained with a capillary precipitin test. the new procedure employed a modification of the phadebact procedure that permitted the grouping of streptococci on glass slides with a minimum of five primary isolated colonies. when only five to eigh ... | 1978 | 357443 |
| [serratia infection]. | | 1978 | 357775 |
| [serratia marcescens, pseudomonas aeruginosa and urinary tract infections]. | | 1978 | 357787 |
| orotate phosphoribosyltransferase: orotidylate decarboxylase (serratia). | | 1978 | 357892 |
| protoplast-like structures formation from two species of enterobacteriaceae by fosfomycin treatment. | a procedure for protoplasts formation from escherichia coli and serratia marcescens by treatment with fosfomycin alone is described. this method gives high and low yields of stable protoplasts from e. coli and s. marcescens respectively. in the last case numerous spheroplasts were obtained. electron micrographs of intact cells, protoplasts and spheroplasts are shown. | 1978 | 358939 |
| efficiency of bacterial filtration in various commercial air filters for hospital air conditioning. | filtration efficiency of high-efficiency particulate air (hepa) filters is said to be over 99.97% of removal rate against the mist of thermogenerating-type of dioctyl phthalate with average particles diameter of 0.3 micrometer, as tested by the u.s. military standard 282 (1956). filtration of bacterial aerosols through commercial air filters was tested to examine the efficiency of bacterial filtration with eight kinds of air filters. percentage of bacterial filtration efficiency (% bfe) of three ... | 1978 | 359187 |
| endemic serratia marcescens in the veterans administration hospital in pittsburgh, pa., 1971--1976. | the incidence of infections due to serratia marcescens increased steadily at the veterans administration hospital in pittsburgh, pennsylvania from 1970 to mid 1975 followed by a decline extending into 1977. one hundred eighty-four serratia marcescens isolates were collected from 123 patients over a 4-month period in 1975 and were characterized by stereotype and antibiotic sensitivity. three-fourths of the isolates were clinically significant. among 24 stereotypes o-:h2 predominated in the urinar ... | 1978 | 359506 |
| macrophage stimulation by bacterial lipopolysaccharides. ii. evidence for differentiation signals delivered by lipid a and by a protein rich fraction of lipopolysaccharides. | stimulation of macrophages to lyse tumor cells is a property common to lipopolysaccharide (lps) extracted from a variety of smooth and rough bacterial strains by several different preparative procedures. the relationship between macrophage stimulation and the structural characteristics of lps is defined. in protein-free lps, lipid a bears the stimulatory signal which results in the differentiation of elicited macrophages into killer cells. the polysaccharide moiety is neither stimulatory itself ... | 1978 | 359747 |
| medical treatment of serratia arthritis with trimethoprim-sulfamethoxazole. | a patient with moderately severe rheumatoid arthritis and diabetes mellitus receiving steroids developed septic arthritis due to serratia marcescens. treatment with a new cephalosporin analogue, intra-articular and intramuscular gentamicin, and chloramphenicol alone and in combination proved ineffective. finally, trimethoprim-sulfamethoxazole therapy, given for a protracted period, eradicated the infection without the need for surgical drainage. | 1978 | 359887 |
| [effect of selected microorganisms on the content of various chemical substances stored in the form of medicinal solutions. iii. effects of serratia marcescens 6/46 and staphylococcus aureus 209 p]. | | 1978 | 360778 |
| performance of enterobacteriaceae identification systems. an analysis of college of american pathologists survey data. | commercial systems designed and marketed for evaluation of enterobacteriaceae are used in many clinical microbiology laboratories. evaluations of these systems have been reported from several large laboratories. identifications with one or more of these systems were compared with those obtained by conventional methods with many strains of organisms. the microbiology resource committee of the college of american pathologists designed two surveys to evaluate the performances of commercial systems ... | 1978 | 360823 |
| the genus serratia. | | 1978 | 360966 |
| the inactivation of gentamicin and netilmicin by carbenicillin: its effect on serratia marcescens. | ten clinical isolates of serratia marcescens were tested on mueller-hinton agar containing gentamicin or netilmicin with carbenicillin. the isolates grew on plates where inactivation occurred, at higher antibiotic concentrations, but failed at lower concentrations. this growth response was individualistic and not closely related to the minimum inhibitory concentrations. | 1978 | 361665 |
| serratia marcescens: a study of the sensitivity of british isolates to antibacterial agents and their combinations. | | 1978 | 361679 |
| trypsin peptide patterns of tryptophan synthase beta2 protein among four species of the enterobacteriaceae. | the tryptophan synthase beta 2 protein (ec 4.2.1.20) of escherichia coli, enterobacter aerogenes, serratia marcescens, and erwinia carotovora was purified and compared. two-dimensional total peptide patterns for each of the four beta2 proteins obtained after digestion with trypsin showed that approximately three quarters of the total peptides are common to all four peptides. examination of only arginine-containing peptides showed that approximately half of these peptides are common. from a compa ... | 1978 | 361723 |
| construction of an l-arginine-producing mutant in serratia marcescens. use of the wide substrate specificity of acetylornithinase. | l-arginine biosynthesis in serratia marcescens sr41 was found to be controlled by (a) feedback inhibition of n-acetylglutamate synthetase and (b) repression of some l-arginine biosynthetic enzymes, and an l-arginine-degrading system was found to exist. accordingly, an l-arginine-producing mutant (aru argr arga) of s. marcescens sr41 was constructed as follows. a mutant incapable of l-arginine utilization (aru) was obtained from the wild strain. subsequently, from the lysine auxotroph (lysa) of a ... | 1978 | 361732 |
| marine cardioactive agents. adenosine and 2'-deoxyadenosine from dasychalina cyathina. | | 1978 | 362107 |
| [increasing incidence of serratia marcescens bacteraemia in intensive care patients (author's transl)]. | the incidence of serratia marcescens in an intensive care unit was investigated in course of several years. after a trial of cephalosporin-gentamycin prophylaxis, infection and death due to serratia rose dramatically. the significance of decreased resistance to infection, hygiene regimes as well as mode of administration of antibiotics is related to selection of this rare microorganism causing septicemia. | 1978 | 362983 |
| pulmonary clearance of serratia marcescens in calves. | the pulmonary clearance rate of serratia marcescens was determined in 17 calves exposed to an aerosol from a modified hendersen apparatus. the mean bovine pulmonary clearance was 50.2 +/- 4.1% at postaerosolization hour (pah) 1, 72.5 +/- 7.0% at 2 hours, 88.6 +/- 5.2% at 4 hours, 97.3 +/- 2.8% at 8 hours, and 99.9% at pah 24 and 48. regional pulmonary mean percent retention (mpr) of s marcescens in 10 calves was determined in dorsal or ventral and in cranial or caudal regions. dorsal mpr was les ... | 1978 | 362992 |
| intraventricular administration of amikacin for complicated gram-negative meningitis and ventriculitis. | four pediatric neurosurgical patients with gram-negative meningitis and ventriculitis were treated with parenteral and intraventricular amikacin, a new aminoglycoside. the organisms infecting these patients were resistant to multiple antimicrobial drugs but were sensitive to amikacin. treatment was continued for 14 days after cerebrospinal fluid cultures became negative. all four patients were cured and have demonstrated no nephrotoxicity, ototoxicity, or evidence of persistent infection on foll ... | 1979 | 363982 |
| a simple and safe volumetric alternative to the method of miles, misra and irwin for counting viable bacteria. | a rapid and simple method for counting viable bacteria is described. the technique involves the use of a semi-automatic micropipette and disposable glass-capillary tubes. viable counts obtained by this method were not significantly different from those obtained by the miles, misra and irwin method or by a pour-plate method. the micropipette procedure is less hazardous than techniques involving the use of calibrated dropping pipettes. | 1978 | 364070 |
| [effect of glucose concentration on the biosynthesis of prodigiosin by serratia marcescens (author's transl)]. | serratia marcescens is an enterobacteria which produces a characteristic red pigment denominated prodigiosin. to study the effect of glucose on the kinetics of this secondary metabolite, cultures of serratia marcescens s10 were incubated at 30 degrees c in the mineral medium gl, with glucose (2 g/l) as the carbon source. prodigiosin production in relation to glucose consumption is studied, and parallel-wise, the effect of various concentrations of glucose on prodigiosin production. the kinetics ... | 1978 | 364562 |
| [investigation in vitro synergism on ampicillin with cloxacillin and dibekacin against glucose non-fermenting gram-negative bacilli and serratia (author's transl)]. | | 1978 | 366194 |
| the regulatory region of the trp operon of serratia marcescens. | the nucleotide sequence of the regulatory region of the trp operon of serratia marcescens is presented. it contains a transcription termination control site in the transcribed leader region preceding the first structural gene of the operon as well as a regulated promoter/operator transcription initiation region. the structural organisation of the leader region differs substantially from that of escherichia coli. | 1978 | 366432 |
| the effect of 1,4-diazabicyclo[2.2.2.]octane on the radiosensitivity of bacteria. | | 1978 | 366645 |
| [changes effected in "serratia marcescens" from treatment with eritrocina (author's transl)]. | | 1978 | 367293 |
| complement-dependent hemodynamic and hematologic changes in the rabbit. | the intravenous injection of the anticomplementary protein from cobra venom, cobra factor (cof),2 induces decreases in mean arterial blood pressure and circulating platelets in rabbits. the changes are rapidly reversed. both changes require the presence of c3 and occur in rabbits genetically deficient in the sixth component of complement. the hypotensive effects of cof were blocked by the histamine h2-receptor antagonist burimamide. an acute c3-dependent change in blood pressure and circulating ... | 1977 | 367962 |
| synergism of aminoglycosides and carbenicillin against resistant strains of serratia marcescens. | | 1979 | 368005 |
| outer membrane of serratia marcescens: apparent molecular weights of heat-modifiable proteins in gels with different acrylamide concentrations. | the major proteins from the outer membrane of serratia marcescens sm-6 are heat modifiable. the analysis of their apparent molecular weights in gels with different concentrations of acrylamide and the results obtained by radioactive labeling indicate that the major proteins are covalently linked to carbohydrate moieties. | 1979 | 368037 |
| conservation of primary structure of the pyridoxyl peptide of escherichia coli and serratia marcescens tryptophan synthase beta2 protein. | two labeled peptides were recovered from tryptic digests of the nab3h4-reduced, performic acid-oxidized beta2 protein of serratia marcescens tryptophan synthase. these two pyridoxyl peptides were identical except for the presence or absence of an nh2-terminal arginyl residue. tryptic digestion of nonreduced, performic acid-oxidized protein allowed isolation of the peptides that comprise the two halves of the pyridoxyl peptide. the partial primary structure for this region of the protein was show ... | 1979 | 368042 |
| [arrangement in chromatin of dna sites accessible to serratia marcescens endonuclease]. | splitting of dna in rat thymus nuclei by serratia marcescens endonuclease has been studied. dna fragments were analyzed by gel electrophoresis. obtained data indicate that the internucleosomal dna interacts with histones octamer and is cut by endonuclease to fragments multiple of 10 nucleotides. limits digestion of nuclei with serratia endonuclease (up to 50% of dna acid solubility) leaves in a nondegraded form the chromatin fragments including dna pieces up to 1000 bases in size-resistant dna. ... | 1978 | 368599 |
| gene fusion during the evolution of the tryptophan operon in enterobacteriaceae. | | 1979 | 368647 |
| [antimicrobial therapy of bacterial endocarditis]. | | 1979 | 368665 |
| [gram-negative bacteria as agents of intrahospital infections]. | | 1978 | 369251 |
| further taxonomic characterization of the genus bdellovibrio. | cultures of bdellovibrio isolated from different geographic locations have been studied in terms of deoxyribonucleic acid analysis (% g + c, genome size, and dna hybridization), cytochrome spectrum, and host range. isolates of the genus exhibit a broad range of % g + c ranging from 37 to 51% and the genome sizes extend from 1300 x 10(6) to 1700 x 10(6) daltons. dna hybridization continues to reveal a high level of genetic heterogeneity. bdellovibrio 3294 exhibits 32% relative reassociation to bd ... | 1978 | 369668 |
| protection kinetics of additives on survival of lyophilized bacteria. | | 1978 | 369773 |
| serratia marcescens: historical perspective and clinical review. | | 1979 | 370597 |
| nucleosome packing in chromatin as revealed by nuclease digestion. | chromatin dna of rat thymus nuclei was cleaved by serratia marcescens endonculease. the fragments have been examined by polyacrylamide gel electrophoresis under denaturing conditions. the results obtained are interpreted to mean that the internucleosomal dna is cleaved by the endonuclease into fragments which are multiples of 10 nucleotides. the 10 nucleotide periodicity in fragmentation of internucleosomal dna is independent of the presence of histone h1 and is likely to be determined by the in ... | 1979 | 370787 |
| [transforming activity of plasmid r6k dna on serratia marcescens strain 20-10. the behavior of the plasmid in the transformants]. | the authors described transformation of s. marcescens, strain 20-10, of the isolated r6k plasmide dna. as demonstrated by centrifugation in cesium chloride gradient and electrophoresis in agarose, the plasmide was present in the transformants in the form identical to r6k in e. coli k12. analysis of the transforming activity of r6k plasmide from serratia and e. coli k12 strains with a complete and defective restriction system showed s. marsescens, strain 20-10, to possess specific system of restr ... | 1978 | 371301 |
| [gibbs free energy in periodic enterobacterial cultures]. | the authors present the results of study of the gibbs' free energy (--delta g) output in periodic cultures of nonpathogenic and enteropathogenic escherichia, shigellae, salmonellae, proteus, serratia, and klebsiellae in the hydrolysate broth in a special twelve--chamber cultivator. graphic expression--deltag = f(n) permitted to reveal differences in the energy characteristics of individual enterobacteria genera and species. it is supposed that such studies could be useful in the choice of redox ... | 1978 | 371306 |
| bacteriocin typing of serratia marcescens. a simplified system. | the authors describe a simplified system for the detection of bacteriocin production by serratia marcescens with the use of six indicator strains, which include escherichia coli, klebsiella pneumoniae, citrobacter diversus, enterobacter aerogenes (two strains), and serratia rubidaea grown on arabinose minimal medium plates. of the 64 possible bacteriocin types, 11 were observed; 66% of the isolates tested were found to be one of three types. occasionally more than one bacteriocin type was observ ... | 1979 | 371382 |
| regulation of extracellular protease formation by serratia marcescens. | heavy cell suspensions of serratia marcescens, when grown in gelatin-containing media, produce extracellular proteases which increase in specific activity in a linear fashion for 3 to 4h. during partial purification, a single peak of proteolytic activity was demonstrated by sephadex g-100 chromatography. however, electrophoresis using 5% polyacrylamide gels discloses three proteolytically active bands. evidence in favor of gelatin acting as an inducer of the 'proteolytic system' was provided by ... | 1979 | 371774 |
| detection of pigment precursors in white clinical strains of serratia marcescens. | filter paper strips containing a pigment precursor extracted from serratia marcescens strain 933 were used to determine whether white, clinical s. marcescens strains could form pigment syntrophically. in all, 114 strains (113 of clinical origin) were tested, and 99% were found to develop colors ranging from violets to pinks. | 1979 | 372232 |
| [opportunistic infection in medicine: study on its causative organisms (author's transl)]. | | 1979 | 372637 |
| efficient transfer of conjugative plasmids by multipoint inoculation and some observations on host range and prevalence of r plasmids. | | 1978 | 372969 |
| platelet transfusion-induced serratia marcescens sepsis due to vacuum tube contamination. | | 1979 | 373177 |
| patient factors contributing to the emergence of gentamicin-resistant serratia marcescens. | one hundred forty nosocomial serratia marcescens infections (including 76 cases of bacteremia) were identified by prospective surveillance from 1975 through 1977 and retrospective chart review from 1968 through 1974. thirty-four cases (24 per cent) involved gentamicin-resistant strains. all gentamicin-resistant strains appeared after 1974. ninety per cent of the patients had undergone surgery, and 88 per cent had received prior antimicrobial therapy. the emergence of gentamicin-resistant s. marc ... | 1979 | 373434 |
| nucleosome-nucleosome interaction in chromatin. | | 1979 | 374121 |
| [modified method for determining water pollution by using a serratia marcescens culture]. | the method for determining the degree of water pollution with the aid of a bacterial tracer has been improved by using: (1) a technique for maintaining the culture of serratia marcescens; (2) a medium whose composition provided for a high level of prodigiosin in the bacterial culture; and (3) an express method for assaying the degree of pigmentation during growth of ser. marcescens on solid media. | 1979 | 375044 |
| yersinia enterocolitica as an etiology of foodborne illness in man. | | 1977 | 375241 |
| [biosynthesis and assembly of outer membrane proteins of escherichia coli (author's transl)]. | | 1979 | 375315 |
| changes in hypothalamic lh-rh content and blood levels of lh-rh, gonadotropin and estradiol during the preovulatory stage of rat estrous cycle. | in order to investigate the sequence of events concerning gonadotropin surge, serum lh, fsh and estradiol concentrations were measured during the rat estrous cycle as well as hypothalamic and blood levels of lh-rh in the preovulatory stage. normally cyclic female wistar rats kept on 12 hr light (from 22.00 hr to 10.00 hr) and 12 hr dark were killed at different times of day during each stage of the cycle. the hypothalamus was quickly dissected out, divided into 3 portions (the anterior, middle a ... | 1978 | 376305 |
| characterization of porins from the outer membrane of salmonella typhimurium. 2. physical properties of the functional oligomeric aggregates. | we have purified to homogeneity, from mutant strains of salmonella typhimurium, the small oligomers of porin that confer permeability channels to artificial vesicle membranes reconstituted from phospholipids and lipopolysaccharide. the molecular weights of the porin oligomers from the strains sh5551 and sh6017 appeared to be 130000 and 125000, respectively, and those of the monomers were 41000 and 37500, respectively, when determined by sedimentation equilibrium in the presence of dodecylsulfate ... | 1979 | 376311 |
| affinity chromatography of putrescine oxidase from micrococcus rubens and spermidine dehydrogenase from serratia marcescens. | putrescine oxidase [ec 1.4.3.4], putrescine : oxygen oxidoreductase (deaminating) (flavin-containing), from micrococcus rubens and spermidine dehydrogenase from serratia marcescens were adsorbed on amine-sepharose 4b in which one of the terminal amino groups of diamine or triamine was covalently bound to sepharose 4b leaving the other terminal amino group(s) free. the affinities of these enzymes for the amine-sepharose 4b increased on increasing the chain length of the methylene groups in the im ... | 1979 | 376502 |
| substrate binding characteristics of the active site of spermidine dehydrogenase from serratia marcescens. | the substrate specificity of spermidine dehydrogenase from serratia marcescens was studied using many kinds of naturally occurring and synthetic polyamines. diamines inhibited the enzyme competitively and their inhibitor constants tended to decrease with increasing methylene chain length in the diamines. all of the triamines and tetramines examined were active as substrates, and the amines containing a 4-aminobutylimino moiety (nh2(ch2)4nh-) in their structures were more active. n-alkylputrescin ... | 1979 | 376503 |
| [transfer ribonucleic acids. structure-functional aspects]. | | 1977 | 377057 |
| a correlative study of immunofluorescence, electron, and light microscopy in immunologically mediated renal tubular disease in man. | renal biopsy specimens obtained from patients with various chronic nephropathies were studied by immunofluorescence (if), electron and light microscopy. of 49 biopsies studied by if, 22 had granular deposits of igg and/or c3 along the basement membranes of proximal tubules while 14 had linear and 13 both linear and granular deposits. the possible importance of immunologically mediated renal tubular lesions in chronic nephropathies is discussed. | 1979 | 377110 |
| physical map of the seven ribosomal rna genes of escherichia coli. | escherichia coli dna was digested with restriction endonucleases bamhi, psti, ecori, sali, hindiii, xhoi, bglii, smai, hpai and with selected double and triple combinations of the same enzymes. the digests were electrophoresed and hybridized with 32p-labelled ribosomal rna by using the southern blotting technique. the resulting bands could be arranged into seven groups, and it was possible to construct a unique physical map of the seven rrna genes (operons) of the bacterial chromosome. mapping i ... | 1979 | 377232 |
| arachidonic acid metabolism in polymorphonuclear leukocytes: effects of ionophore a23187. | addition of arachidonic acid and the divalent cation ionophore a23187 to a suspension of human peripheral blood polymorphonuclear leukocytes led to the formation of (5s)-hydroxy-6,8,11,14-icosatetraenoic acid, (15s)-hydroxy-5,8,11,13-icosatetraenoic acid, and (5s,12r)-dihydroxy-6,8,10,14-icosatetraenoic acid. a method based on high-pressure liquid chromatography has been developed for assay of these metabolites. the addition of arachidonic acid to human polymorphonuclear leukocytes always result ... | 1979 | 377292 |
| reclassification of incompatibility group l (incl) plasmids. | | 1979 | 377325 |
| [clinico-bacteriologic study of an outbreak of enterobacter-serratia infection]. | | 1979 | 377922 |
| quantitative comparison of electrophoretic traces of bacterial proteins. | | 1979 | 378522 |
| in vitro additive effect of nitrofurantoin combined with trimethoprim-sulfamethoxazole against serratia marcescens. | the combination of nitrofurantoin (nf) plus trimethoprim-sulfamethoxazole (tmp-smz) was found to be additively effective against all of 12 clinical isolates of serratia marcescens that represented 7 nosocomially significant strains, some of which were mulitple-drug-resistant. all isolates were resistant against nf; minimal inhibitory concentrations (mics) ranged from 320 to 1,280 microgram nf/ml. the isolates were inhibited by tmp-smz concentrations ranging from 0.03 microgram tmp + 0.57 microgr ... | 1979 | 378572 |
| nonspecific resistance of serratia marcescens against antimicrobial drugs. resistance or decreased susceptibility of phenotypic variants against chloramphenicol, nalidixic acid, nitrofurantoin, sulfonamides and trimethoprim. | several clinical isolates and o-antigen reference strains of serratia marcescens were shown to yield spontaneously phenotypic variants with nonspecific, combined resistance or decreased susceptibility for chloramphenicol, nalidixic acid, nitrofurantoin, sulfonamides, and trimethoprim, including cotrimoxazole. additional presumptive evidence indicated that this resistance phenomenon is not mediated extrachromosomally, but rather chromosomally. the nature of this novel resistance mechanism remains ... | 1979 | 378575 |
| nonspecific aminoglycoside cross-resistance of serratia marcescens. | 10 of 11 clinical isolates of serratia marcescens yielded small numbers (10(-7) to 10(-8)) of 'gray' colony-type variants after selection with either amikacin, gentamicin or kanamycin, of which most proved resistant against all of the following aminoglycoside antibiotics: amikacin, gentamicin, kanamycin, neomycin, netilmicin, sisomicin and streptomycin. the level of resistance was not absolute, but rather low-level to intermediate. all except two of these 'gray', resistant phenotypic variants yi ... | 1979 | 378576 |
| [determination of endotoxemia by means of the limulus test in patients with septicemia (author's transl)]. | the limulus test was applied to determine bacterial endotoxemia in 42 patients suspected of having septicemia. hemocultures were practiced simultaneously. a comparative study is made of the two presently most commonly recommended tests for neutralizing the factors inhibiting the endotoxin-amebocyte reaction. according to our results the dilution of plasma in isotonic saline solution is preferable; we obtained a sensitivity of determination of 0.0001 micrograms of e. coli endotoxin per ml of plas ... | 1979 | 379472 |
| serratia marcescens. | | 1979 | 379645 |
| antibiotic-resistant serratia marcescens infection in a hospital. | over a 12-month period, 74 isolates of serratia marcescens were obtained from various sources at tygerberg hospital. the majority of these isolates were from catheterized patients with urinary tract infections, and were non-pigmented and resistant to all antibiotics tested, excepting amikacin and neomycin. all isolates transferred resistance to tobramycin, gentamicin and tetracycline by conjugation to escherichia coli recipients as separate markers at low frequency. a non-self-transmissible plas ... | 1979 | 380020 |
| eikenella corrodens and pulmonary infections. | | 1979 | 380422 |
| thienamycin: new beta-lactam antibiotic with potent broad-spectrum activity. | thienamycin, a new beta-lactam antibiotic, exhibited potent, broad-spectrum activity in vitro against gram-negative bacilli and gram-positive cocci, including many isolates resistant to currently available antibiotics. all isolates were inhibited at concentrations less than or equal to 25 mug/ml, with the exception of 12% of isolates of enterobacter spp. and 3% of isolates of serratia marcescens. its activity decreased with an increase in inoculum concentration of from 10(5) to 10(7) cells per m ... | 1979 | 380462 |
| effect of clavulanic acid on the in vitro synergism between carbenicillin and gentamicin against serratia marcescens. | clavulanic acid, a potent beta-lactamase inhibitor, reduced the minimum inhibitory concentrations of carbenicillin for 13 of 15 clinical isolates of serratia marcescens by at least eightfold. the combination of clavulanic acid and carbenicillin also exhibited synergistic activity with gentamicin against 11 of 15 isolates tested, including 9 of 10 strains which were highly resistant to carbenicillin (minimum inhibitory concentration >/= 8,000 mug/ml) and had previously been found resistant to the ... | 1979 | 380465 |
| effects of high doses of a series of new luteinizing hormone-releasing hormone analogues in intact female rats. | a new series of lh-rh analogues containing an azgly10 modification and having potent agonist properties were given in high concentration to intact female rats. plasma lh and fsh were raised to extremely high levels after 14 days' administration of the compounds (5.0 and 0.5 microgram/rat twice daily), but plasma oestradiol concentrations were reduced to those in ovariectomized rats. the weights of the ovary and uterus were also markedly reduced, suggesting that these compounds are, on this treat ... | 1979 | 380619 |
| variation among mouse strains in responsiveness to migration inhibitory factor. | | 1979 | 380823 |
| [sero-types and drug sensitivity of serratia marcescens isolated from pathological specimens, with special reference to hospital infections. ii. (author's transl)]. | | 1979 | 381707 |
| [a case of brain abscess due to serratia marcescens (author's transl)]. | | 1979 | 381965 |
| intracellular and extracellular radiosensitization of serratia marcescens by bipyridinium compounds. | | 1979 | 382234 |
| biochemical characteristics and antibiotic susceptibilities of serratia marcescens isolated from clinical specimens. | | 1978 | 382648 |
| purification and characterization of the extracellular proteinase of serratia marcescens. | the extracellular proteinase produced by a depressed strain of serratia marcescens atcc 25419 was purified and characterized. this produces more than 10-times the amount of extracellular proteinase produced by other strains of serratia tested. the purified enzyme was prepared from the culture supernatant by (nh4)2so4 fractionation and deae-cellulose chromatography. the purified enzyme has an so20,w of 3.95 and is a monomer of molecular weight 51,900. the proteinase has a broad ph optimum in the ... | 1979 | 383155 |
| serratia marcescens bacteremia from contaminated pressure transducers. | primary serratia marcescens bacteremia developed in 17 patients in an intensive care unit after exposure to pressure monitoring devices. a study showed that all of the transducer heads were contaminated with s marcescens, and prospective culturing of 110 pressure monitoring lines disclosed a 24% rate of contamination with the same organism. hand contamination occurs at the time the equipment is initially assembled; in five of eight trials, transmission was shown experimentally to occur by direct ... | 1979 | 384037 |
| [the influence of short-term lead exposure on the bacterial clearance of the lung (author's transl)]. | the experiments describe the effects of short-term application of low concentrations of lead on the elimination of bacteria in the lungs of laboratory animals. on five subsequent days over a period of three weeks female mice of the nmri strain were exposed for one and three hours, respectively, to a lead aerosol (mean concentration 13,14 micrograms/m3 lead chloride). then the animals inhaled fitc labeled non pathogenic bacteria of the species serratia marcescens. the lungs of the animals examine ... | 1979 | 384725 |
| evidence that bacteria can form new cells in airborne particles. | serratia marcescens incubated for 8 h at 31 degrees c in a chemically defined medium contained in shake flasks was aerosolized into rotating-drum aerosol chambers at 30 degrees c and saturated humidity. cells furnished tryptone (difco) and glycerol just before aerosolization increased (in viable numbers and countable cells) almost twofold within 1 to 2 h after becoming airborne, whereas cells not furnished additional tryptone decreased in viable numbers at a faster rate than the number of partic ... | 1979 | 384900 |
| new prodigiosin-like pigment from alteromonas rubra. | the red prodigiosin-like pigment from alteromonas rubra was shown to be a mixture of prodigiosin (pigment 1) and a new cyclic isomer (pigment 2). the new structure was elucidated by mass and nuclear magnetic resonance spectra. careful examinations of the prodigiosins produced by serratia marcescens, vibrio psychoerythrus, and an unidentified red bacterium (ll-100-6) failed to disclose any of the new pigment, pigment 2. | 1979 | 384909 |
| relaxed mutants of serratia marcescens sm-6. biochemical traits and relevance of the rel+ allele for the formation of exoenzymes. | serratia marcescens sm-6 when starved for a required amino acid stops synthesizing protein and rna and accumulates two nucleotides which co-chromatograph with ppgpp and pppgpp. these features are characteristic of bacterial strains with stringent rna control (rel+). two independent mutants were isolated which resemble relaxed (rela) mutants of escherichia coli; they continue to synthesize rna and accumulate neither ppgpp nor pppgpp when deprived of the required amino acid. the extracellular enzy ... | 1979 | 384954 |
| [effect of the carbon/nitrogen ratio on the antibiotic activity of prodigiosin]. | the antibacterical activity of prodigiosin varies according to the c/n ratio in the cultural media for s. marcescens. in organic media, as nutrient agar, peptone or soytone, the optimal ratio lies between 4 and 5, and higher values are required for "mineral media" where the nitrogen source is essentially an ammonium salt. the separate c source would be probably used as "acetate source" for the synthesis of the terminal alkylpyrrole. | 1979 | 385408 |
| activity of cefuroxime, cefoxitin and amikacin against serratia marcesens. | | 1979 | 385581 |
| rapid determination of microbial batch culture stage. | | 1979 | 387116 |
| analysis of mitotic nondisjunction with aspergillus nidulans. | two methods to detect the induction of nondisjunction with a diploid stable strain of a. nidulans are described. the first method gives only qualitative results, while the second method is quantitative and dose-effect curves can be done. some physiological parameters affecting the induction of nondisjunction can also be studied, because either quiescent or germinating conidia can be treated with the drug under test. some agents inducing nondisjunction were also tested for the induction of point ... | 1979 | 387402 |
| [nuclease-antibodies in infections with serratia marcescens (author's transl)]. | a total of 467 presumable healthy men of age eighteen yielded titres of anti-serratia-nuclease that ranged from 1:4 to 1:6. one third of 56 patients, who had been infected with serratia marcescens (urinary-, wound-, respiratory-infections, and bacteremia) yielded raised anti-nuclease titres, which amounted maximaly 1:16. the diagnostic utility of this serological test was discussed. | 1979 | 387574 |
| requirements of immunoglobulin and the classical and alternative complement pathways for phagocytosis and intracellular killing of multiple strains of gram-negative aerobic bacilli. | the requirements for immunoglobulin and the alternative and classical complement pathways for phagocytosis and intracellular killing of clinical isolates of escherichia coli, proteus mirabilis, klebsiella pneumoniae, and serratia marcescens by normal human polymorphonuclear leukocytes were determined. human sera deficient in immunoglobulin or classical pathway activity, or both, were compared for their ability to promote phagocytosis os and killing of 13 bacterial strains by the polymorphonuclea ... | 1979 | 387613 |
| evolution of multiple-antibiotic-resistance plasmids mediated by transposable plasmid deoxyribonucleic acid sequences. | two plasmid deoxyribonucleic acid sequences mediating multiple antibiotic resistance transposed in vivo between coexisting plasmids in clinical isolates of serratia marcescens. this event resulted in the evolution of a transferable multiresistance plasmid. both sequences, designated in tn1699 and tn1700, were flanked by inverted deoxyribonucleic acid repetitions and could transpose between replicons independently of the excherichia coli reca gene function. tn1699 and tn1700 mediated ampicillin, ... | 1979 | 387747 |
| the enzymes of the galactose cluster in saccharomyces cerevisiae. purification and characterization of galactose-1-phosphate uridylyltransferase. | | 1979 | 387754 |
| serotyping of serratia marcescens: current status of seven recently described flagellar (h) antigens. | the slightly revised, current scheme of 20 flagellar (h) antigens of serratia marcesens was examined. the seven new h antigens were demonstrated to be antigenically distinct as determined with le minor's h-immobilization test. the h-immobilization antibodies of rabbit anti-h immune sera proved resistant to treatment with 2-mercaptoethanol and dithiothreitol, respectively. on the other hand, dual absorptions of rabbit anti-h immune sera with killed cells of staphylococcus aureus strain cowan i, i ... | 1979 | 387810 |
| serratia marcescens in tracheotomy cultures. | twenty-three consecutive tracheotomies were cultured after an apparent outbreak of serratia marcescens was noted. over a period of one year, six cases with positive cultures were found. the importance of these positive cultures in relation to the patient's clinical course is discussed. the treatment of serratia marcescens septicemia is reviewed. | 1979 | 388124 |
| in vitro investigations with fosfomycin on mueller-hinton agar with and without glucose-6-phosphate. | determination of the minimal inhibitory concentration of fosfomycin in the agar dilution test on mueller-hinton agar showed that the addition of glucose-6-phosphate to the nutrient medium potentiates the action of fosfomycin against escherichia coli, klebsiella, enterobacter, citrobacter and staphylococcus aureus, sometimes by as much as 256-fold. such a potentiation of action was not detectable with serratia marcescens, the individual proteus species, pseudomonas aeruginosa or enterococci. fosf ... | 1979 | 389806 |
| in vitro activity of cefamandole, cefoxitin, cefuroxime, and carbenicillin, alone and in combination with aminoglycosides against serratia marcescens. | synergistic antibiotic studies were undertaken to compare the effectiveness of two new beta-lactamase resistant cephalosporins, cefamandole, and carbenicillin, with four aminoglycosides against clinical strains of serratia marcescens. the strains demonstrated various combinations of resistance and/or susceptibility to the antibiotics tested. tobramycin was the most effective aminoglycoside when used in combination with beta-lactam antibiotics. carbenicillin and cefamandole demonstrated similar a ... | 1979 | 390321 |
| antimicrobial susceptibility of clinical isolates of serratia marcescens. | the in vitro susceptibilities of 242 isolates of serratia marcescens to 17 antibacterial drugs have been determined. oxolinic acid, nalidixic acid, cefoxitin, and amikacin were the most active drugs. ampicillin, kanamycin, and cephalothin were among the least active. a 4-year study showed that resistance of s. marcescens to dibekacin, tobramycin, sisomycin, and gentamicin has increased at least one order of magnitude in that period, whereas resistance to amikacin showed but a twofold increase. | 1979 | 391150 |
| serratia strains colonising the gut of newborns. | | 1979 | 391251 |
| hybrid tryptophan synthase beta 2 proteins: apparent conservation of the beta-beta binding region of the beta monomer among enteric bacteria. | purified borohydride-reduced tryptophan synthase beta 2 protein (ec 4.2.1.20) from escherichia coli and purified native beta 2 protein from serratia marcescens were mixed and dissociated in urea. removal of the urea resulted in random reassociation of the reduced and native beta monomers, forming interspecies hybrid beta 2 molecules. interspecies hybrid beta 2 protein molecules of the reciprocal composition were also formed. interspecies hybrid reconstituted molecules were formed with approximat ... | 1979 | 391801 |
| transductional construction of a threonine-producing strain of serratia marcescens. | a threonine-producing strain of serratia marcescens sr41 was constructed according to the following process. thr- strain e-60 was derived from strain hnr59 having constitutive levels of threonine-sensitive aspartokinase and homoserine dehydrogenase. thr+ transductant t-570 was constructed from strain e-60 and phage grown on strain hnr21 having feedback-resistant threonine-sensitive aspartokinase and homoserine dehydrogenase. this transductant lacked both feedback inhibition and repression for th ... | 1979 | 393167 |