| electron-microscopic study of a mycoplasmatales virus, strain mv-lg-ps2-l 172. | morphology and adsorption of a globular virus, lysing acholeplasma laidlawii were studied in ultrathin sections of plaques in a lawn of the host strain. the virus was globular, about 50 to 90 nm in diameter, with a clearly defined membrane, 6.5 to 8 nm thick. a protuberance about 25 to 35 nm long and 12 to 20 nm thick was observed on numerous virus particles. the evenly granulated, electron-optically dense content of the cells became clearer in cells affected by the viruses. fibrillar structures ... | 1975 | 234904 |
| cerebral vasculitis in rheumatoid arthritis. | a 63-year-old man with severe, untreated rheumatoid arthritis and pleuritis developed an unusual neurological syndrome similar to gerstman syndrome, followed by dementia and blindness, six weeks before his death. an autopsy showed extensive necrotizing vasculitis, resembling polyarteritis nodosa, involving the brain and resulting in numerous infarcts. the disease was most severe in the posterior portion of the cerebral hemispheres. other organs were only slightly involved. severe amyloidosis of ... | 1975 | 235911 |
| electrolyte secretion by the magnum of the domestic fowl during egg-shell calcification. | | 1975 | 236134 |
| immunodeficiency in the chicken. iii. hypoplasia of bursal follicles following intravenous injection of embryos with lipopolysaccharide or allogeneic lymphocytes. | intravenous injection of lps or allogeneic lymphocytes resulted in impaired maturation of b cells within the bursa of chick embryos. a gradual decline in the sensitivity of embryos towards both agents was reflected by a decrease in the number and size of bursal follicles following injection between 10 and 15 days of embryonation. the hypoplasia of these follicles in embryos injected with lymphocytes on the 10th day was a more sensitive measure of graft-versus-host reaction than splenomegaly. the ... | 1975 | 236984 |
| standardisation of the nitroblue-tetrazolium test. | optimal conditions for the nbt-reduction test have been sought. increasing heparin concentrations up to 100 units per ml and a delay in performance of the test, especially when blood specimens are kept at room temperature, resulted in higher values for the nbt index, which then sometimes exceeded the upper limit of normal in healthy people and in uninfected patients. the effect of ph, composition of the buffer, and dye concentration was also investigated. phosphate-buffered saline ph 7-2 contain ... | 1975 | 238038 |
| glutathione biosynthesis in escherichia coli k 12. properties of the enzymes and regulation. | the synthesis of glutathione in escherichia coli k 12 was studied in crude, cell-free extracts. the ph optima and the apparent km values for the substrates have been determined for both synthesizing enzymes, gamma-glutamylcysteine synthetase and glutathione synthetase. gamma-glutamylcysteine synthetase was found to be approximately twice as active as glutathione synthetase. in a growing culture, the cellular level of gsh showed a considerable increase up to 6.6 mumol per ml cell pellet in the st ... | 1975 | 238647 |
| some distinctive characteristics of the alkaline phosphatase of serratia marcescens. | a mutant strain of serratia marcescens produces a constitutive enzyme (phosphatase f), which differs from the alkaline phosphatase of escherichia coli in the following characteristics: one enzyme species with higher mobility on electrophoresis, less heat stability, no rapid reactivation following exposure to high hydrogen ion concentrations, no hybridization with e. coli enzyme in vitro, little activation at increased ionic strength, greater sensitivity to edta inhibition, and no cross reaction ... | 1975 | 238723 |
| role of cytochrome b5 in nadph-and nadh-dependent hydroxylation by the reconstituted cytochrome p-450- or p-448-containing system. | | 1975 | 239545 |
| nephrotic syndrome in schistosomiasis mansoni complicated by chronic salmonellosis. | thirteen patients with concomitant chronic salmonellosis and schistosomiasis and with the nephrotic syndrome were studied. of the seven patients' sera examined, all had markedly low complement c3 and near normal c4 levels. this indirectly suggests an active role of salmonella endotoxin in the etiology of the nephrosis. | 1975 | 239605 |
| the effect of local anesthetic, lidocaine, on guinea pig trachealis muscle in vitro. | the effect of lidocaine was studied in guinea pig trachealis muscle by dose-response reversal and protection of agonist-induced contractures in a superfusion system. lidocaine reversed histamine, acetylcholine, and depolarizing hypertonic potassium contractures with the median effective doses of 2.8, 6.0, and 3.2 mg. lidocaine presuperfusion shifted in a nonparallel fashion (p less than 0.05) the dose-response of histamine, acetylcholine, depolarizing potassium, and supramaximal electrical stimu ... | 1975 | 240301 |
| [synthetic medium for testing of susceptibility. ii. susceptibility of bacteria to sulphonamides (author's transl)]. | a comparative study of 9 media for testing the susceptibility of bacteria to 7 sulphonamides has been carried out. the evaluated culture-media included 4 "mueller hinton" media (mh), 4 others based on the formula of the "diagnostic sensitivity test" agar base (d.s.t.) and a "synthetic medium" (sm) which has been developed in our laboratory. mh and d.s.t. culture-media have been supplied by 4 manufacturing companies in europe and usa. a total number of 21 bacterial cultures have been employed. th ... | 1975 | 241178 |
| separatin of the canine fabella. | | 1977 | 243325 |
| [in vitro antibacterial activity of tobramycin used in combination with cephalothin or carbenicillin (author's transl)]. | combinations of tobramycin (tob) with cephalothin (cet) or carbenicillin (cbpc) were evaluated by in vitro test against 161 clinical isolates of klebsiella pneumoniae, escherichia coli, indole-positive proteus, enterobacter and serratia marcescens which were not inhibited by 6.25 microgram/ml of cet. the combinations were considered to show synergy when there was a 4-fold or greater reduction in mic values (fic index less than or equal to 0.5) of both antibiotics when combined. synergy of tob wi ... | 1978 | 246946 |
| [talampicillin hydrochloride: comparison with amoxicillin and ampicillin in the antibacterial activity and pharmacokinetics (author's transl)]. | the antibacterial activities, absorption and excretion of talampicillin hydrochloride were compared with those of amoxicillin and ampicillin. talampicillin hydrochloride showed a broad-spectrum antibacterial activity against gram-positive and gram-negative bacteria as seen in amoxicillin and ampicillin. the antibacterial activities of talampicillin hydrochloride, amoxicillin and ampicillin were quite similar. in experimental murine infection with staphylococcus aureus, protective effect of talam ... | 1978 | 246947 |
| spot on! that's the name of the game. | | 1978 | 252032 |
| surgical correction of perosis in a 3-week-old mallard duck. | | 1978 | 252349 |
| hr 756, a highly active cephalosporin: comparison with cefazolin and carbenicillin. | hr 756, a new parenteral cephalosporin, was compared with cefazolin and carbenicillin for activity against a total of 264 strains of pseudomonas aeruginosa, escherichia coli, klebsiella spp., proteus mirabilis, proteus spp. (indole positive), enterobacter spp., salmonella typhi, serratia marcescens, providencia stuartii, and staphylococcus aureus. in every comparison, except that with the last organism, hr 756 was clearly more active than cefazolin and carbenicillin. all three compounds had simi ... | 1978 | 253572 |
| resection and anastomosis of the trachea for removal of an intraluminal foreign body. | | 1979 | 260564 |
| studies on recently isolated cultures of methicillin-resistant staphylococcus aureus. | of 19 recently isolated cultures of methicillin-resistant staphylococcus aureus, 18 showed inducible low-level resistance to minocycline, 15 showed high-level resistance to streptomycin, and 4 showed resistance to low levels of streptomycin. two cultures produced yellow pigment and may have been derived in vivo by loss of a gene(s) determining orange pigment. treatment of three cultures with serial exposures to n-methyl-n'-nitro-n-nitrosoguanidine resulted in a widening of phage typing pattern t ... | 1979 | 261529 |
| experimental studies on the biological properties of bordetella pertussis. | | 1979 | 262507 |
| studies on the tissue specificity of a circulating renotropic factor. | in 1970, it was found that sera removed from rats 24 hr after unilateral nephrectomy stimulate the incorporation of 3h-thymidine into the dna of incubating rat renal cortex. the same sera did not influence isotope incorporation into the dna of incubating liver, spleen, and lung tissue. later, a substance was described in renal tissue that enhanced the action of the renotropic factor in sera. it was proposed that this tissue factor activated the circulating renotropic substance and that lack of t ... | 1979 | 263165 |
| thermotaxis by pseudoplasmodia of dictyostelium discoideum. | the temperature dependence of migration rate and of the thermotactic sensitivity of pseudoplasmodia of dictyostelium discoideum has been measured. migration rate increases with temperature to 20 degrees, is temperature insensitive from 20 degrees to 27.5 degrees, and decreases with temperature to 29 degrees, above which point migration ceases. however, pseudoplasmodia formed from cells grown at 23.5 degrees are thermotactic only from 22 degrees to 27.5 degrees. thus, a temperature dependence of ... | 1977 | 266720 |
| liver crude phospholipid and in vitro calcification. | | 1977 | 267111 |
| lack of effect of topical calcitonin on connective tissue. | | 1977 | 267112 |
| fluorescence banding techniques in the identification of sibling species of the anopheles gambiae complex. | the mitotic chromosomes of the sibling species a and b of the anopheles gambiae complex were stained with hoechst 33258 and examined by fluorescence microscopy. the autosomes fluoresce homogenously and similarly in both species while the sex chromosomes differ in the location and brightness of some heterochromatic blocks. these cytochemical differences allow the cytotaxonomic identification of these cryptic species. | 1977 | 268309 |
| a site-specific single-strand endonuclease from the eukaryote chlamydomonas. | we have found a unique deoxyribonuclease in extracts of the eukaryotic green alga chlamydomonas. when incubated with viral dna from adenovirus-2, this enzyme produces discrete fragments that form bands upon electrophoresis in an agarose gel. site specificity of the enzymatic cleavage examined by identifying the 5'-terminal nucleotides in cleaved adenovirus-2 dna and by studies with synthetic polynucleotides of defined sequence, indicates that the initial endonucleolytic cleavage occurs at a site ... | 1977 | 268618 |
| the investigation of a recurrence of an ahc virus epidemic at lucknow: a serosurvey for ahc virus antibodies before and after the epidemic. | an epidemic of acute haemorrhagic conjunctivitis (ahc) recurred at lucknow during july to september 1975, after a gap of 4 years. out of the 35 cases investigated thoroughly, 20 entero-70-like cytopathogenic agents were isolated from the conjunctiva which were neutralized by antisera against ahc virus j670/71 of japan. seroconversion was seen in 7 out of 11 paired sera from patients. serological study was also done on 100 sera collected before the ahc epidemic of 1971, 100 sera after 1971 and 10 ... | 1977 | 269197 |
| surgical treatment of chronic osteomyelitis of the mandible resistant to intraarterial infusion of antibiotics: report of case. | a 47-year-old man with chronic osteomyelitis of the mandible is described. the patient had frequent episodes of acute and subacute exacerbation at varying intervals for a period of six years in spite of extended antibiotic therapy. intraarterial infusion of antibiotics through the superficial temporal artery also failed to cause any improvement. he was finally treated successfully by surgical intervention. | 1977 | 269233 |
| [histochemical characteristics of the oral mucosa in dogs with experimental stomatitis]. | | 1977 | 269530 |
| transitions in collagen types during matrix-induced cartilage, bone, and bone marrow formation. | the localization of types i, ii, and iii collagens during bone matrix-induced sequential differentiation of cartilage, bone, and bone marrow was studied by specific immunofluorescence. subcutaneous transplantation of coarse powders of demineralized rat bone matrix into allogeneic recipients resulted in new bone formation. after a transient appearance of polymorphonuclear leukocytes in the implant, fibroblasts appeared in close continguity to the matrix on day 3. type iii collagen was then locali ... | 1977 | 271986 |
| effect of pituitary hormones on dentin production in maxillary incisors in the rat. | the effect of pituitary hormones on dentin production and longitudinal growth of the maxillary incisors in normal and hypophysectomized rats was investigated. bovine growth hormone was found to increase the dentin production slightly in normal rats and significantly in hypophysectomized rats. other pituitary hormones showed no effects on dentin apposition in the doses and periods tested. the effects of the pituitary hormones on the longitudinal growth of the tooth were small or insignificant. th ... | 1978 | 274804 |
| [myelomonocytoid leukemia, abnormal cellular clone with a marker chromosome, evolution with a possible cure]. | | 1978 | 274914 |
| effect of ethylenethiourea on hepatic microsomal enzymes in the rat. | | 1978 | 277101 |
| the effect of some divalent cations on extracellular polysaccharide synthesis in streptococcus salivarius. | the amount of extracellular insoluble polysaccharide produced by streptococcus salivarius can be effected by some divalent cations. calcium at concentrations of 1 x 10(-3) and 10(-4) m caused a reduction in polysaccharide synthesis. magnesium at 1 x 10(-3) m inhibited extracellular polysaccharide production but at 1 x 10(-4) m had little effect. manganese was without effect on polysaccharide synthesis. zinc at 1 x 10(-3) and 1 x 10(-4) m caused a substantial increase in extracellular polysacchar ... | 1978 | 277538 |
| induction of colon tumors in 1,2-dimethylhydrazine-resistant lobund wistar rats by methylazoxymethanol acetate. | sprague-dawley and lobund wistar rats, which were sensitive and resistant to induction of colon tumors by 1,2-dimethylhydrazine (dmh), respectively, were treated with methylazoxymethanol (mam), the product of dmh metabolism by the microsomal mixed-function oxidase system. although the colon tissue in both stocks of rats had similar nad+-dependent dehydrogenase activities that are considered necessary to activate mam to an ultimate carcinogen, still a sevenfold greater incidence of colon tumors w ... | 1978 | 277733 |
| implanted tissue-cages: a critical evaluation of their relevance in measuring tissue concentrations of antibiotics. | in several species of laboratory animals, the concurrent serum and tissue-cage fluid levels of several antibiotics after a single parenteral dose have markedly different profiles. new work has shown that these differences are mainly due to the relatively impermeable granulomatous sheath which develops around the implanted tissue chambers. the concentrations of an antibiotic in tissue-cage fluid are therefore not representative of its concentration in "interstitial fluid" or extravascular fluid i ... | 1978 | 278148 |
| [experimental approval of agents for preventing oral tissue lesions from iodine vapors]. | | 1978 | 278295 |
| the effects of diphenylhydantoin and vitamin d deficiency on developing teeth in the rat. | | 1978 | 278547 |
| glucocorticoid receptors and sensitivity of isolated human leukemia and lymphoma cells. | | 1978 | 279402 |
| reaction of hydrogen sulphide with proteins associated with the human mouth. | | 1978 | 283741 |
| effect of acute ascorbic acid deficiency on the dna content and permeability of guinea-pig oral mucosal epithelium. | | 1978 | 283748 |
| effects of 5-methoxy-n,n-dimethyltryptamine on behavior and raphe unit activity in freely moving cats. | 5-methoxy-n,n-dimethyltryptamine (5-meodmt) produced a dose-dependent decrease in the discharge rate of serotonin-containing neurons in the dorsal raphe nucleus of freely moving cats. this ranged from a 15% decrease at 10 microgran/kg, i.m., to a virtual complete depression of activity at 250 microgram/kg. 5-meodmt's effects on raphe units occurred with a very short latency (3-5 min) and its duration of action was dose-dependent and limited to an hour or less. the degree of depression of raphe u ... | 1979 | 283930 |
| stress analysis of porous rooted dental implants. | | 1977 | 283973 |
| collagen reduces glycosaminoglycan degradation by cultured mammary epithelial cells: possible mechanism for basal lamina formation. | collagenous substrates are reported to promote the accumulation of extracellular matrix materials by epithelia in culture. glycosaminoglycan (gag) metabolism is compared in secondary cultures of mouse mammary epithelial cells maintained on plastic or type i collagen gel substrates. the incorporation of 35so42- into gag during brief labeling indicates no difference between substrates in the rate of gag synthesis. during prolonged labeling, however, accumulation of [35s]gag in cultures on colllage ... | 1979 | 284399 |
| the effect of lithium and fluoride upon in vitro plaque and bacterial growth. | | 1979 | 285115 |
| effect of beta-blockade on leg blood flow and lactate release in exercising man. | | 1979 | 285574 |
| the proportional volume of mucous acinar cells in normal human submandibular salivary glands. | | 1979 | 294238 |
| unspecific action of opiates on the acetylcholine release from striatal slices. | | 1978 | 296265 |
| different behavioral responses to l-dopa after anterolateral or posterolateral hypothalamic injections of 6-hydroxydopamine. | after bilateral microinjections of 6-hydroxydopamine (6-ohda) into the anterolateral (al) or posterolateral (pl) hypothalamus l-dopa (1,3,4-dihydroxy-phenylalanine) produced running and rearing in al6-ohda rats and oral stereotypies in pl 6-ohda rats. since the same dose of l-dopa had no behavioral effect in vehicle injected rats, the responses to l-dopa of both al and pl 6-ohda rats are examples of behavioral supersensitivity. the different forms of behavioral supersensitivity correlated with d ... | 1977 | 303138 |
| induction in b2/b2 chickens of immunity to transplantable carcinogen-induced fibrosarcomas mediated by t-cell monocyte cooperation: role of delayed hypersensitivity to unrelated antigens. | | 1977 | 303451 |
| antibiotic decontamination of the dog and its consequences. | an isolation-decontamination regimen was developed which effectively reduced the numbers of resident flora of the dog. bacterial counts in four dogs before treatment were 3.8 x 10(9) per gram of feces; no organisms were detectable in these same dogs after treatment, however, the intestinal flora had returned to slightly above normal levels 1 week after treatment. decontamination was accomplished in a laminar air flow system designed to minimize the area that had to be under controlled conditions ... | 1978 | 305504 |
| the unity of genes in the major histocompatibility complex. | the major histocompatibility complex (mhc) of the mouse can be genetically divided into several regions specialized to performing specific functions. thus the class i regions (k and d) code for antigens that activate effector (killer) t cells, class ii region (i) for antigens causing t-cell proliferation, and class iii regions (s) for complement components. a strong case is made for the theory that the division of labor within the mhc is not absolute. evidence is presented that class i antigens ... | 1978 | 307394 |
| combined activitiy of clavulanic acid and ticarcillin against ticarcillin-resistant, gram-negative bacilli. | fifty-one clinical isolates of ticarcillin-resistant, gram-negative bacilli were tested for susceptibility to combinations of ticarcillin and clavulanic acid (brl 14151), a potent beta-lactamase inhibitor. minimal inhibitory concentrations (mics) were measured by a microdilution method, and minimal bactericidal concentrations for selected strains were measured by the broth dilution method. ticarcillin mics were >/=128 mug/ml for all and >/=512 mug/ml for 38 (75%) of the strains. thirty-nine stra ... | 1978 | 308792 |
| apparatus for uniaxial testing of soft human tissues in vitro. | | 1978 | 309051 |
| immunoregulatory responses in experimental disseminated histoplasmosis: depression of t-cell-dependent and t-effectory responses by activation of splenic suppressor cells. | the cellular immune responses of mice with disseminated histoplasmosis are markedly diminished in association with the generation of potent immunosuppressor activity by spleen cells. the zenith of suppressor activity was observed during most active infection, from 1 to 3 weeks after inoculation. during this time there was: (i) depression of the delayed-type hypersensitivity response to sheep erythrocytes and histoplasmin, (ii) impairment of concanavalin a- and histoplasmin-induced blastogenic tr ... | 1979 | 313371 |
| [current aspects on the pathogenesis and treatment of fever]. | | 1979 | 313869 |
| the proliferative capacity of human t lymphocyte subpopulations in a continuous culture system. | the continuous growth of subpopulations of human t lymphocytes was investigated using a culture system containing conditioning factors from mitogen-stimulated lymphocytes. cultures of purified peripheral blood lymphocytes rapidly became enriched for t lymphocytes, detected as sheep erythrocyte rosette-forming cells, and could be maintained for up to a month in an actively growing state. subpopulations of t lymphocytes bearing fc receptors for igm(t.m) or igg(t.g) could not be detected in these c ... | 1979 | 314897 |
| pharmacological study of a new non-steroidal anti-inflammatory drug: protacine (cr 604). | the pharmacological activities of 3'-(4-[2-(1-p-chlorobenzoyl-5-methoxy-2-methyl-indol-3-yl-acetoxy)-ethyl]-piperazin-1-yl)propyl-4-benzamido-n,n-dipropylglutaramate(+/-)dimaleate (protacine, cr 604), a new indolyl derivative with strong anti-inflammatory, analgesic and antipyretic activities, are described. the dose-dependent activity of protacine on inflammation has been shown both in short-term experiments, like the hind paw edema induced by carrageenin and several other irritants, and long-t ... | 1979 | 315235 |
| second international workshop on alloantigenic systems in the rat: combined report on reference testing of anti-t-lymphocyte alloantisera. | | 1979 | 315636 |
| in vitro antibacterial activity of cefoperazone (t-1551), a new semisynthetic cephalosporin. | cefoperazone, a new semisynthetic cephalosporin, has a broad spectrum of antibacterial activity. it is as active as cefazolin and cefamandole against gram-positive bacteria and is more active than cefazolin and cefamandole against such gram-negative bacilli as escherichia coli, klebsiella pneumoniae, proteus species, pseudomonas aeruginosa, citrobacter freundii, enterobacter cloacae, and serratia marcescens. the superiority of cefoperazone over cefazolin and cefamandole with respect to activity ... | 1979 | 316988 |
| comparison of antibacterial activity of a new cephalosporin, ceftizoxime (fk 749) with other cephalosporin antibiotics. | fk 749 is a distinctive new parenteral cephalosporin antibiotic with a broad antibacterial spectrum which is more potently active against a wide variety of gram-negative bacilli, including the opportunistic pathogens such as citrobacter and enterobacter species and serratia marcescens, than sce 963, t 1551 and cefmetazole. the activity of fk 749 against escherichia coli, klebsiella pneumoniae, pyogenes was by far superior to that of the three other antibiotics. these test organisms were not resi ... | 1979 | 317284 |
| biosynthesis of prodigiosin by non-proliferating wild-type serratia marcescens and mutants deficient in catabolism of alanine, histidine, and proline. | mutants of serratia marcescens nima, designated as aut, hut, or put, did not utilize l-alanine, l-histidine, or l-proline, respectively, as a sole carbon source but did utilize other amino acids or glycerol as carbon sources. the bacteria were permeable to alanine, histidine, and proline but lacked the enzymes responsible for degradation of these amino acids. the aut mutant contained no l-alanine dehydrogenase activity, whereas the hut and put mutants contained only 7 and 4% of the histidase and ... | 1977 | 318635 |
| antibiotherapy of serratia marcescens septicemia in children. | the clinical and bacteriological response of 38 treatments performed on 24 children (11 of them neonates) carrying out separate treatments with carbenicillin (2 treatments), gentamicin [4], fosfomycin [6], and associated treatments with gentamicin plus carbenicillin [6], fosfomycin plus gentamicin [18] and fosfomycin plus carbenicillin [2] are considered. the clinical cure was obtained in 21 children (87.5%). the most effective treatment was fosfomycin plus gentamicin; both antibiotics showed sy ... | 1977 | 318977 |
| ex vivo hemodialysis culture of microbial and mammalian cells. | a small hemodialysis culture unit was developed which can be attached to an arterial-venous shunt and worn by an animal for days. the unit consists of a blood channel separated by a membrane from a dialysate chamber in which microbial or mammalian cells can be cultured. bacterial multiplication proceeded first exponentially at the maximal rate and then arithmetically at a lesser, dialysis-limited rate. in a survey of 16 pathogenic microorganisms and five types of mammalian cell, results indicate ... | 1977 | 319177 |
| taxonomy of the genus serratia. | one hundred and fifty-six strains of serratia and related bacteria including representatives of enterobacter liquefaciens, enterobacter cloacae, enterobacter aerogenes, erwinia carotovora, erwinia chrysanthemi, erwinia herbicola and erwinia nimipressuralis were studied using 223 morphological, physiological, biochemical and carbon source utilization tests. the results were subjected to computer analysis. at the 80% similarity level all strains, except two, grouped into eight phenons representing ... | 1977 | 319202 |
| prosthetic valve endocarditis by opportunistic pathogens. | the incidence of endocarditis produced by the so-called "opportunists" as a complication of prosthetic valve surgery is progressively increasing in frequency and gradually transforming the clinical picture habitually associated with this disease. we report six cases of endocarditis produced by opportunistic microorganisms (two cases by candida, and the remaining by serratia, actinobacillus, acinetobacter calcoaceticus, and bacteroides fragilis, and by corynebacterium diphtheriae) in four male an ... | 1977 | 319774 |
| serratia marcescens arthritis in heroin addicts. | serratia appears as a pathogen of increasing frequency and clinical significance in bone and joint infections in heroin users. this is the fifth case report of septic arthritis due to serratia marcescens in intravenous heroin users. the clinical and laboratory features were not different from other acute pyogenic arthritides. signs of infection were obscure even in the presence of debilitating disease. although pseudomonas and staphylococcus are more common organism in bone and joint infections ... | 1977 | 319929 |
| norvaline accumulation by regulatory mutants of serratia marcescens. | a gene coding for desensitized l-threonine dehydratase was transduced with phage ps20 into a leucine accumulator of serratia marcescens sr41. the transductant converted l-threonine to alpha-ketobutyrate, a precursor of both norvaline and isoleucine. an isoleucine-valine auxotroph of the transductant accumulated large amount of norvaline from l-threonine as well as from d-threonine. | 1977 | 320169 |
| retention of pacemaker electrode complicated by serratia marcescens septicemia. removal with total cardiopulmonary bypass. | a case in which serratia marcescens septicemia complicated the insertion of a transvernous pacemaker unit is reported. appropriate antibiotic therapy and removal of the pacemaker electrode are two essential steps to achieve a complete cure in this stimulation. open cardiotomy with total cardiopulmonary bypass provides a safe approach for withdrawal of an incarcerated electrode and is justified because of the lethal potential of systemic serratia infections, particularly those superimposed on int ... | 1977 | 320397 |
| endotoxin effects on the liver. | | 1977 | 320416 |
| [entobacterial transformation by r6k plasmid dna]. | preparations of dna of r6k plasmide obtained by various methods on the basis of the "clarified" lysate: by gel filtration on sepharose 4b, centrifugation in cesium chloride with ethidium bromide gradient, were analysed in the e. coli c600. s. typhimurium ag37, pr. vulgaris 4636, s. marcescens 20-10 transformation. the frequency of transformation proved to depend on the extent of dna purification. factors influencing the e. coli c600 competence and the transformation efficacy (the phase of the cu ... | 1977 | 320804 |
| ascaris suum: lymphoid cell responses during secondary infections in the guinea pig. | | 1977 | 321239 |
| species variation in pancreatic islet monoamine uptake and action. | there are conflicting data in the literature regarding the role of monamines in the secretion of insulin. in order to clarify the contribution that species variation may make to these divergent results, the uptake of serotinin (5-ht), dopamine (da), and their precursor amino acids, 5-hydroxytryptophan (5-htp) and l-dopa, into islets was studied. islets from golden hamsters, rabbits, guinea pigs, and obese, hyperglycemic mice were isolated by the collagenase technique. the islets were incubated i ... | 1977 | 321287 |
| serotyping of serratia marcescens: evaluation of le minor's h-immobilization test and description of three new flagellar h antigens. | the h-immobilization test of le minor for determining flagellar (h) antigens was evaluated and compared with tube and slide h-agglutination tests. the test proved specific and easy to perform, and titration end points were clearly discernible. the degree of serological cross-reactivity between h antigen reference strains of serratia marcescens was low. consequently, this test was adopted for routine serological analysis of h antigens, using unabsorbed rabbit immune anti-h sera. as a result of us ... | 1977 | 321468 |
| a simple one-step hemolytic assay for c2 with c2-deficient human serum. | a simple one-step procedure has been developed for the molecular titration of c2 by utilizing the ability of the test material to restore the hemolytic activity of human serum selectively deficient in c2 (c2d serum). in this assay, equal volumes of ea (10(8) cells/ml), c2d serum (1/20), and a suitable dilution of a source of c2 were incubated at 37 degrees c for 60 min and the fraction of cells lysed was used to calculate the effective molecules of c2/ml test material. the assay can be used to t ... | 1977 | 321681 |
| therapy for experimental intraabdominal sepsis: comparison of four cephalosporins with clindamycin plus gentamicin. | an experimental model of intraabdominal sepsis in rats was used for evaluation of treatment with four cephalosporins: cephalothin, cefazolin, cefoxitin, and cefamandole. doses were 115 mg of each of the cephalosporins/kg and, in additional experiments, 350 mg of cephalothin or cefazolin/kg. response to treatment was evaluated by mortality rate and the incidence of intraabdominal abscess. all four cephalosporins and gentamicin produced a similar reduction in mortality rates. there was a marked va ... | 1977 | 321707 |
| oestrogen-induced changes in the secretion of luteinizing hormone caused by continuous infusions of luteinizing hormone releasing hormone in the long-term ovariectomized rat. | oestrogen-induced changes in luteinizing hormone secretion, caused by continuous infusions of luteinizing hormone releasing hormone (lh-rh), appear to depend on the duration of exposure of the pituitary gland to the releasing hormone. the initial oestrogen-induced depression of the potential response of the pituitary gland to lh-rh, which always seems to occur, does not necessarily turn into an enhancement of this potential response. it is suggested that this may be due to the fact that the resp ... | 1977 | 321721 |
| alteration of free serum amino acids in voles infected with trypanosoma brucei gambiense. | free serum amino acid pools of field voles, microtus montanus, were determined over a 24 hr period, and compared to values obtained from voles infected with trypanosoma brucei gambiense. the majority of amino acids in the control animals demonstrated a diurnal variation, peaking predominantly during the dark portion of the photoperiod. this trend was not evident in the infected animals. in addition, infected voles possessed an apparent state of hypoaminoacidemia, with levels of threonine, serine ... | 1977 | 321737 |
| septicemia secondary to impacted infected pacemaker wire. successful treatment by removal with cardiopulmonary bypass. | infection of an intravenous pacemaker electrode developed in a 78-year-old man after multiple replacements and revisions of the pulse generator and the pacemaker lead. spread of the infective process to the endocardium was followed by septicemia with serratia marcescens and staphyloccus epidermids. failure of medical treatment and external traction on the pacemaker electrode led to thoracotomy and removal of the pacemaker electrode wires with the use of extracorporeal circulation. the tip of one ... | 1977 | 321883 |
| pyrimidine biosynthesis in serratia marcescens: polypeptide interactions of three nonsequential enzymes. | orotidine-5'-monophosphate pyrophosphorylase (ompppase, e.c. 2.4.2.10) and orotidylate decarboxylase (ompdecase, e.c. 4.1.1.23) were purified from serratia marcescens hy. these enzymes required physical association for maximal catalytic activities and formed a fragile complex with dihydroorotase (dhoase, e.c. 3.5.2.3). ompppase reversibly lost 50% of its activity upon separation from dhoase. the kinetic characteristics of ompppase were modified by this separation. in the presence of dhoase, the ... | 1977 | 322653 |
| scanning electron microscopy: morphology of aortic endothelium following injury by endotoxin and during subsequent repair. | a single injection of endotoxin p45 poly serratia marcescens was used to induce endothelial injury in rabbits. the aortic endothelium was examined by scanning electron microscopy (sem), at various times after administration of endotoxin, using the technique of silver staining and pressure fixation. within one hour after injection, some endothelial cells were curled-up and spindle-shaped in appearance. areas of aorta devoid of endothelial cover were occasionally observed and platelets were someti ... | 1977 | 322678 |
| protection by hypoxia and the effect of low oxygen tensions on radiosensitivity. | | 1977 | 323029 |
| [use of prodigiozan in treating vibration disease]. | | 1977 | 323109 |
| radiosensitization of hypoxic cells by a nitrofuran; dose-modifying and shoulder effects. | the radiosensitizer nifurpipone dihydrochloride (5-nitro-2-furaldehyde n-methyl piperazino acetyl hydrazone dihydrochloride) sensitizes hypoxic v79 mammalian cells by at least two mechanisms. sensitization is by a reduction of ñ in addition to an increase in slope. both these affects are absent under oxygenated conditions. when hypoxic v79 cells are irradiated in the presence of nifurpipone dihydrochloride combined with ro-07-0582, sensitization greater than that due to air alone is observed; th ... | 1977 | 323170 |
| determination of antibacterial antibodies in serum by immunoradiometric assays. | when used to determine immunopurified antibacterial globulins in saline-phosphate buffer, the detection sensitivities of direct competitive and indirect immunoradiometric assays were respectively 25 and 2 ng. normal human and rabbit sera interfered in both types of assay, markedly decreasing sensitivity and precision. various pre-treatments of sera and modifications of reaction conditions substantially decreased interference in the competitive assay without affecting the activity of added antibo ... | 1977 | 323486 |
| [effect of prodigiozan on the phagocytic activity of the leukocytes in melioidosis intoxication]. | in development of experimental melioidosis intoxication, the activity of the mechanisms controlling non-specific immunological reactions changed that was evident from changes both in the quantitative and qualitative indices of phagocytosis. the absorption function of the neutrophils was lowered during 2 days from the moment of administration of acetone killed bacterial mass of the melioidosis causative agent which was evident from decreased percentage and index of phagocytosis as compared to the ... | 1977 | 324384 |
| resistance plasmid transfer by serratia marcescens in urine. | resistance plasmids were transferred in urine from a multi-drug-resistant serratia marcescens to escherichia coli. transfer of resistance to kanamycin, tetracycline, chloramphenicol, streptomycin, ampicillin, and carbenicillin occurred readily after 4 h of incubation at room temperature (25 degrees c). the urinary catheter collection bag is postulated as a potential site for extraintestinal resistance plasmid transfer in the enterobacteriaceae, especially for pathogens such as serratia, which do ... | 1977 | 324391 |
| sequential hospitalwide outbreaks of resistant serratia and klebsiella infections. | late in 1973 at the nashville veterans administration hospital, an intrusion of serratia marcescens infections that were resistant to gentamicin sulfate and other antimicrobial agents occurred. this abated somewhat, only to be superseded by another wave of multiply-resistant infections due to klebsiella pneumoniae beginning in the spring of 1974. approximately 400 patients had substantial infections with these organisms during the 2 1/4 year period, imposing considerable morbidity and mortality. ... | 1977 | 324421 |
| nosocomial epidemics seriatim. multidrug-resistant bacteria and r factors. | | 1977 | 324422 |
| outbreaks of serratia and klebsiella infections. | | 1977 | 324424 |
| serratia marcescens infections in general hospitals. | | 1977 | 324564 |
| in vitro susceptibility of cephalothin-resistant enterobacteriaceae to cefoxitin and bl-s786. | the in vitro antibacterial activity of two agents relatively resistant to beta-lactamases, bl-s786 and cefoxitin, was tested against 123 recent different clinical isolates of cephalothin-resistant enterobacteriaceae. bl-s786 showed considerable activity against escherichia coli and lesser activity against klebsiella pneumoniae with, respectively, 68% and 41% inhibited at 32 microng/ml. cefoxitin showed more activity in vitro against e. coli, k. pneumoniae, serratia marcescens and providencia stu ... | 1977 | 324961 |
| the use of antibiotic combinations in the treatment of serratia marcescens infections. | | 1977 | 324966 |
| serratia marcescens in a general hospital. | fourteen patients with infections caused by serratia marcescens were seen over an eight-month period in a large general hospital. predisposing factors suggested an 'opportunistic' pattern similar to that previously described in the united states. s. marcescens is an important pathogen which may be increasing in significance in the united kingdom. multiple resistance of the organism to antibiotics other than gentamicin makes the finding of apparent sensitivity to co-trimoxazole of potential thera ... | 1977 | 325592 |
| [study on serratia marcesceus; biochemical behavior of marcesceus strains and sensitivity to antimicrobials]. | | 1977 | 325609 |
| amikacin therapy of patients with multiply antibiotic-resistant serratia marcescens infections: development of increasing resistance during therapy. | over a recent 22 month period, 222 patients in two adjacent hospitals became infected with a multiply antibiotic-resistant strain of serratia marcescens; 13 were bacteremic. nineteen patients with clinically significant infections received amikacin. nine of 11 patients with urinary tract infections were cured. in contrast, only one of eight patients with pneumonia or other deep tissue infections was cured and four died. these eight patients were severely ill; many had infections with multiple mi ... | 1977 | 326046 |
| solubilization of chromatin with heparin and the isolation of nuclear membranes. | | 1977 | 327198 |
| the use of bacteriophages as indicators in host-mediated assays. longevity of phages lambda, t4 and kappa in the blood-stream of mice. | | 1977 | 327317 |
| bilateral chronic ureteritis associated with serratia marcescens. | to our knowledge this is the first case of bilateral obstructive uropathy caused by nonspecific chronic ureteritis to be reported. prior to operation the bilateral involvement was throught to be due to a tuberculous infection or retroperitoneal fibrosis. the diagnostic difficulties were similar to those previously reported in the unilateral involvement. the focus of the infective organism found was serratia marcescens which originated in the right kindey. | 1977 | 327653 |
| a comparison of typing methods for serratia marcescens. | a simple method for the bacteriocine typing of serratia marcescens without the use of induction was sought. the results of a mutual inhibition experiment with 89 unrelated cultures indicated that a bacteriocine-susceptibility method would give more discrimination between strains than would a bacteriocine-production method. a cross-streaking technique for bacteriocine-susceptibility typing without previous induction was developed, and its performance was compared with that of another susceptibili ... | 1977 | 328770 |