adherence of bacteria to leaves.members of seven genra of bacteria, pathogens and nonpathogens of plants, adhered to young leaves when leaves were suspended in cell suspensions for 10 min. with pseudomonas lachrymans, the adherence rate (cells applied vs. cells adhering) to host (cucumber) and nonhost (chrysanthemum) leaves was a straight-line, log-log function, as was the adherence of escherichia coli and serratia marcescens to cucumber leaves. adhering cells of these three bacteria were washed with water from cucumber leaves ...1979393373
compatible results obtained from biotyping and serotyping in serratia marcescens.the correspondence between complete serotype and biotype (p.a.d. grimont and f. grimont, j. clin. microbiol. 8:73-83, 1978) of 474 serratia marcescens strains was studied. of 127 serotypes, 70 were represented by two or more strains of the same serotype belonged to one biotype. however, for 91% of serotypes, strains of the same serotype belonged to one biogroup--i.e., a group of closely related biotypes. biogroups are a1 (a1a, a1b); a2/6 (a2a, a2b, a6a, a6b); a3 (a3a, a3b, a3c, a3d); a4 (a4a, a4 ...1979393712
[epidemiological study of onchocerciasis and malaria in bamendjin dam area (cameroon). malacologic fauna and risks of schistosomian introduction (author's transl)].report of survey in bamendjin dam area indicates that 25 p. 100 of the population have a blood smear positive for malaria (p. falciparum) and 80 p. 100 have a positive indirect immunofluorescent test for malaria. the vector is a. funestus. in male inhabitants 23,2 p. 100 of the snip-biopsies are positive for o. volvulus and 40 p. 100 of the indirect immunofluorescent test are positive. in female inhabitants the respective ratios are 14,4 p. 100 and 48,8 p. 100. there is no urinary or intestinal ...1979393936
[isolation of the intracellular lipase of serratia marcescens].various methods have been tested in order to isolate endolipase from the cells of serratia marcescens 345: cell disintegration by ultrasound and french press as well as incubation of the cellular suspension with sodium salts of bile acids. the combined effect of ultrasound and these salts on the cellular suspension of s. marcescens 345 was also studied. the highest lipolytic activity was found in the supernatant obtained upon incubation of the cells with sodium cholate at a concentration of 0.8% ...1979393974
[sepsis caused by serratia marcescens. report of 19 cases]. 1979394233
hyperbaric oxygen and chronic osteomyelitis.forty patients with chronic osteomyelitis were treated with hyperbaric oxygen as an adjunct to surgical therapy and antibiotics and followed for an average of 2 years with a recurrence rate of 15%. the mechanism of action of hyperbaric oxygen in osteomyelitis is probably an indirect one of improving local vascularity and potentiating phagocytosis. many of these patients represent a refractory group with poor prognosis due to the etiology of the infection, site of involvement, and duration of inf ...1979394894
evidence for more than one division of bacteria within airborne particles.when the protocol that we had used to demonstrate a single division of bacterial cells in airborne particles was changed to one that increased the glycerol content of the atomizer fluid from 1 to 5% (vol/vol), thus producing larger particles, more than two (and nearly three) divisions of bacteria occurred within 6 h of aerosol time.1979395898
exoenzymatic characteristics and sensitivity to chemotherapeutics of serratia marcescens. their importance in epidemiological investigation. 1978395929
release of alkaline phosphatase activity by aqueous-ether treatment of whole cells of serratia marcescens.the effect of aqueous-ether treatment according to the method of ribi et al. (1961) on the release of alkaline phosphatase from cells of two strains of serratia marcescens was studied. by this method, lipopolysaccharide-protein (endotoxin) complexes associated with alkaline phosphatase activities were released from both strain 08 and strain bizio. sds-polyacrylamide gel electrophoresis followed by enzymatic assay showed the presence of two active components in each strain. fractions released fro ...1979396452
range of antibacterial activity of antibiotics at subminimal inhibitory concentrations: the ratio of minimal inhibitory concentration to minimal antibiotic concentration.the range of activity of subminimal inhibitory concentrations of some beta-lactam and aminoglycoside antibiotics against both gram-negative and gram-positive bacteria was determined and expressed as the ratio of the minimal inhibitory concentration (mic) to the minimal antibiotic concentration (mac). ten strains of staphylococcus aureus were tested with ampicillin, cefamandole, and cefoxitin. the mean mic/mac ratios were 9.4, 14.0, and 2.9, respectively. the mean mic/mac ratios for 10 strains of ...1979396635
serotyping of serratia marcescens: simplified tube o-agglutination test and comparison with other serological procedures.a simplified tube o-agglutination test was developed and evaluated for the determination of somatic serogroup (o) antigens of serratia marcescens. use was made of tryptic soy broth (tsb)-grown o-cells that had been boiled for 1 hour; 0.145 m nacl proved a satisfactory diluent. various technical parameters of this test were examined as well. rabbit anti-o immune sera, that had been elicited with 5 x concentrated, tsb-grown, 1 hour-boiled o-cells of all 15 currently employed o-antigen reference st ...1979396741
[serratia marcescens, a microbial species with potential pathogenicity and increasing clinical importance]. 1979397588
effect of immune sera upon enhanced in vitro antibody responses.immunization of rabbits with s marcescens bacteria in freund's incomplete adjuvant resulted in development of anti-serratia sera with bacterial agglutinating properties as well as lps modulating properties. the antisera reacted with the lps in counterimmunoelectrophoretic assays. such antisera also stimulated the lps induced enhancement of specific anti-srbc responses from normal spleen cell cultures but did not further enhance the stimulated responses of similar cultures incubated with the smal ...1979397749
studies on the endotoxin induced tumor summary, this report has discussed the immunologic mechanisms involved in the enhancement of nonspecific resistance to tumor by endotoxin. the optimal conditions for tumor protection involved pretreatment with approximately 25 mug lps administered at the siteof subsequent tumor challenge. in an attempt to relate endotoxin structural components to the ability to enhance tur, a variety of whole lps's, endotoxic glycolipids and ps preparations were compared. while all of the intact lps's and sev ...1979397758
restoration of depressed antibody responses of leukemic splenocytes treated with lps-induced factors.lipopolysaccharide and a nontoxic derivative, ps, from serratia marcescens were studied in terms of their effects on normal and friend leukemia virus depressed splenocytes. these materials caused a marked increase in the number of antibody producing cells by both groups of splenocytes. mdp, a synthetic analogue of myobacterial cell walls, produced a similar adjuvant response by normal and leukemic splenocytes. combinations of ps or lps and bcg or mdp resulted in synergistic immunostimulatory res ...1979398146
results of chloroquine sensitivity tests in plasmodium falciparum in orissa state. 1979398337
[serratia marcescens, a biologic marker of human stupidity]. 1979398941
[serratia marcescens bacteremia in a neonatal intensive therapy center: epidemiological study].the authors have isolated serratia marcescens in nine coltures of blood, effected during the period genuary 1 - february 28, 1979, in a newborn nursery. they have carried an epidemiologic study in immature ward, in newborn children and sanitary personnel. extensive cultures of objects, equipment and air were negative for serratia marcaescens. the exact mode by which serratia was introduced into the immature ward could not be determined. the authors point out on importance of contamination in new ...1979399170
non-tricyclic antidepressants. 1978400613
in vitro antimicrobial activity of some cyclic hydroxamic acids and related lactams.against enterobacter aerogenes 13048, serratia marcescens 13880, klebsiella pneumoniae 10031, pseudomonas aeruginosa 10145, escherichia coli 9723, lactobacillus casei 7469, lactobacillus plantarum 8014, leuconostoc dextranicum 8086, and streptococcus faecalis 8043, the mean minimal inhibitory concentrations of three cyclic hydroxamic acids, 3-amino-3,4-dihydro-1-hydroxycarbostyril, the 6-chloro analog, and the 7-chloro analog, were 0.6, 0.6, and 0.2 micrograms/ml, and those of the corresponding ...1978400828
infections due to endemic, multiply resistant gram-negative rods: sensitivity to and therapy with cefoxitin.a nosocomial outbreak of infections due to bacteria resistant to multiple antibiotics evolved into an endemic prevalence of several antibiotic-resistant gram-negative rods. the resistance of these bacteria to available beta-lactam antibiotics, a variety of broad-spectrum agents, and available aminoglycosides other than amikacin led to an evaluation of cefoxitin, a beta-lactamase-resistant cephamycin. most multiply resistant isolates of klebsiella pneumoniae, serratia marcescens, and proteus mira ...1979400932
absence of clinical pneumonia following bronchoscopy with contaminated and clean bronchofiberscopes.two hundred forty-nine fiberoptic bronchoscopy procedures were surveyed for the presence of bronchoscopy-related pneumonia. the first 103 procedures were performed during a period when the fiberscope was presemably contaminated with pseudomonas aeruginosa. chart review of these 103 procedures and prospective epidemiologic surveillance of the remaining 146 procedures revealed no cases of bronchoscopy-related pneumonia.1977401481
the urometer as a reservoir of infectious organisms.with the aid of epidemiologic tools such as serotyping and bacteriocin typing, organisms involved in hospital-acquired infections were traced to their hospital reservoir. one of these reservoirs was an instrument used to measure specific gravity of urine, the urometer.1977401556
r plasmids coding for gentamicin, tobramycin, and carbenicillin resistance in serratia, klebsiella and escherichia coli strains from a single clinical source.serratia marcescens, klebsiella sp. and escherichia coli strains bearing transferable resistance to aminoglycoside antibiotics, namely, gentamicin, tobramycin, kanamycin, streptomycin, lividomycin, and carbenicillin, as well as to a series of more classical drugs, began to emerge in materials from the frankfurt university hospital. plasmids from serratia, klebsiella, and e. coli exhibit a broad host range in that they are transferable to e. coli, proteus mirabilis and salmonella typhimurium rece ...1977401718
in vitro activity of netilmicin, gentamicin, and amikacin.the in vitro activity of netilmicin (sch 20569), a new semisynthetic derivative of gentamicin, was compared with that of gentamicin and amikacin. one hundred and ninety-two clinical isolates of enterobacteriaceae, pseudomonas aeruginosa, and staphylococcus aureus were tested using both agar and broth dilution techniques. netilmicin was comparable to gentamicin, with the following exceptions: (i) for serratia marcescens and p. aeruginosa, gentamicin was more active than netilmicin; (ii) all strai ...1977402104
immunochemical comparison of phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase among the enterobacteriaceae.the bifunctional enzyme of the tryptophan operon, phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase (prai-ingps;ec, was characterized by an immunochemical study of six representative members of the enterobacteriaceae: escherichia coli, salmonella typhimurium, enterobacter aerogenes, serratia marcescens, erwinia carotovora, and proteus vulgaris. prai-ingps was purified from e. coli, and antisera were prepared in rabbits. these antisera were utilized in quantitativ ...1977403178
the role of cellular locomotion in leukemic infiltration. an organ culture study on penetration of l 5222 rat leukemia cells into the chick embryo mesonephros.the significance of cellular locomotion for leukemic infiltration was investigated using l 5222 rat leukemia cells. previous cinemicrographic studies have shown that these cells are able to locomote only after formation of a uropod-like posterior extension. this characteristic locomotive configuration of l 5222 cells is easily recognizable in scanning electron micrographs and appropriate sections. leukemia cells were inoculated on slices of chick embryo mesonephros incubated for 24h; at this tim ...1977403674
[fundamental and clinical studies on amikacin (bb-k8) in complicated urinary tract infections (author's transl)]. 1977404447
[a simple method for the determination of pcb in human milk and blood using an improved essential oil distillator (author's transl)]. 1977404452
adults with chronic granulomatous disease of "childhood". 1977407791
effect of aerosol immunization with re 595 salmonella minnesota on lung bactericidal activity against serratia marcescens, enterobacter cloacae, and pseudomonas aeruginosa.intrapulmonary bactericidal activity was measured after mice were given 3 weekly aerosol exposures to acid-hydrolyzed re 595 salmonella minnesota. ten days after their last immunization, mice were challenged with aerolized serratia marcescens, enterobacter cloacae, or pseudomonas aeruginosa. quantitative bacterial counts in ground lung were obtained immediately after exposure and again 4 hours later. enhanced bactericidal activity against serratia marcescens and enterobacter cloacae was seen in ...1977407823
serum dilution test for bactericidal activity. ii. standardization and correlation with antimicrobial assays and susceptibility tests. 1977408424
comparative studies of rna polymerase subunits from various bacteria.the molecular structure of rna polymerases from escherichia coli, salmonella typhimurium, salmonella anatum,serratia marcescens, aerobacter aerogens, proteus mirabilis and bacillus subtilis were compared based on:i) inhibition of the enzyme activity by treatment with antibodies against e. coli rna polymerase subunits;ii) analysis of antibody precipitates by sodium ododecyl sulfatepolyacrylamide gel electrophoresis; and iii) analysis of antibody precipitates by urea-isoelectrofocusing followed by ...1977408600
synergy of vancomycin with penicillins and cephalosporins against pseudomonas, klebsiella, and serratia. 1977408984
further studies on the susceptibility of serratia marcescens to the bactericidal activity of human serum. resistance of isolates against serum transferrin-mediated iron deprivation and chelation of cations by edta. 1977409627
patterns and mechanisms of emergence of resistance to amikacin.emergence of gram-negative bacilli resistant to amikacin occurred in five of 96 patients treated. three of the five instances were associated with clinical failure and arose during therapy for an infection caused by a pathogen also susceptible to gentamicin. the other two episodes were associated with colonization. the enzyme aminoglycoside-6'-acetyltransferase, which inactivates amikacin, was found in serratia marcescens. decreased permeability to amikacin was shown in four isolates of pseudomo ...1977409785
synergistic activity of trimethoprim and amikacin against gram-negative bacilli.the in vitro effect of trimethoprim on the inhibitory and bactericidal activity of amikacin against 20 strains each of klebsiella pneumoniae and serratia marcescens, 15 strains of escherichia coli, and 10 strains of pseudomonas aeruginosa was examined by the checkerboard technique in microtiter plates. trimethoprim had a synergistic effect on the inhibitory and bactericidal activity of amikacin against the majority of non-pseudomonas strains tested. the mean +/- standard deviation fractional inh ...1977410362
[pharmacological and clinical studies on s-6436 in urinary tract infections (author's transl)]. 1977411847
methadone: antimicrobial activity and interaction with antibiotics.we studied the effect of methadone, alone and in combination with antimicrobial agents, on two strains each of staphylococcus aureus, pseudomonas aeruginosa, and serratia marcescens isolated from blood streams of parenteral drug abusers with bacterial endocarditis. methadone has its own antibacterial effect, although at supraphysiological concentrations, and is even synergistic with antimicrobial agents against some organisms. thus, methadone does not interfere with the antibacterial effects of ...1977412466
hand-washing degerming: a comparison of povidone-iodine and chlorhexidine.two antiseptic preparations for hand washing were compared by the glove-juice method in a crossover study on 10 volunteers. the reference preparation was 7.5% povidone-iodine (betadine surgical scrub); the test agent was 4% chlorhexidine gluconate combined with 4% isopropyl alcohol (hibiclens). the experimental model included inoculation of the hands with a mixture of serratia marcescens, escherichia coli, providentia stuartii, and pseudomonas aeruginosa. the reference preparation achieved a red ...1978412637
antimicrobial synergism in the therapy of gram-negative rod determine if antimicrobial synergism might affect the results of treatment of gram-negative rod infections, 444 bacteremias from 1972 through 1974 were studied. on these, 173 were treated with two antibiotics to which the infecting organisms were sensitive. clinical responses were observed in 80% of 83 cases where antibiotic activity was synergistic, as defined by a minimum inhibitory concentration (mic) of each antibiotic in combination being one-fourth or less than the mics of individual dr ...1978412648
nocardicin a, a new monocyclic beta-lactam antibiotic iii. in vitro evaluation.nocardicin a, a new monocyclic beta-lactam antibiotic, exerts a comparatively potent antimicrobial activity against gram-negative organisms, especially pseudomonas aeruginosa, the indole-positive and indole-negative proteus groups (except pr. morganii), serratia marcescens and the neisseria groups. the in vitro antimicrobial activity of nocardicin a against clinical isolates of ps. aeruginosa was about twice that of carbenicillin. the mean mics of nocardicin a for pr. mirabilis, pr. rettgeri and ...1977412823
[hospital infections from a bacteriological viewpoint].in spite of the successful treatment of bacteriological infections combined with progress in hospital hygiene there remain still problems of infective hospitalism in certain sections of the hospital. generally, the causative bacteria are nosoparasites not being dangerous to human beings in good condition. from this point of view pseudomonas aeruginosa and serratia marcescens are the most important species. a successful challenge against infective hospitalism is only possible under the supervisio ...1977412996
experimental evaluation of hr756, a new cephalosporin derivative: pre-clinical 756 is a new cephalosporin derivative suitable for parenteral use. the compound possesses an unusally broad spectrum of antibacterial activity especially against gram-negative bacteria. besides escherichia coli, salmonella, klebsiella, indole-negative proteae and other species also indol-positive proteae, serratia marcescens, enterobacter and many pseudomonas aeruginosa strains are inhibited by this compound. hr 756 is stable to most of the beta-lactamases produced by gram-negative organisms. ...1977413795
characteristics of a complex formed by a nonintegrated fraction of transforming dna and bacillus subtilis recipient cell constituents. 1977414068
breast versus bottle feeding. 1977414178
[congenital iatrogenic abnormalities of the human eye]. 1977414843
ultrastructure of the condylar articular surface in severe mandibular pain-dysfunction syndrome.specimens from articular surfaces of normal human mandibular condyles are compared with very small biopsies from articular surfaces of condyles taken at conservative operations in severe pain-dysfunction syndrome (p.d.s.). immediate fixation was followed by examination using transmission electron-micrography. normal surfaces exhibit a nearly structureless layer about 2 micron thick, which corresponds with the lamina splendens described in other diarthrodial joints. this layer surmounts a dense m ...1977415013
trail phenomena in connexion with serratia phages and marcescin-like activities. 1978415120
the inhibitory effect of the artificial electron donor system, phenazine methosulfate-ascorbate, on bacterial transport mechanisms.the artificial electron donor system, phenazine methosulfate (pms)-ascorbate, inhibited active transort of solutes in pseudomonas aeruginosa irrespective of whether the active transport systems were shock sensitive or shock resistant. n,n,n',n'-tetramethylphenylenediamine could be substituted for pms but a higher concentration was required. pms-ascorbate also inhibited active transport in several other bacterial species with the exception of escherichia coli and of a nonpigmented strain of serra ...1977415185
gentamicin-resistant bacillary infection. clinical features and amikacin therapy.infections caused by gentamicin sulfate-resistant pseudomonas aeruginosa and serratia marcescens have occurred in multiple areas of our hospitals and have caused serious clinical illness and death. isolates of pseudomonas organisms were sensitive to some alternative drugs including collstin sulfate, but isolates of serratia organisms were often resistant to all commercially available parenteral antimicrobiais. all isolates were inhibited by amikacin sulfate, and 95% were killed by concentrations ...1978415674
[study on bacteriocin (marcescin) typing of serratia marcescens. i. fundamental studies on bacteriocin (marcescin) production and sensitivity (author's transl)]. 1977416153
carboxymethylcellulase produced by facultative bacteria from the hind-gut of the termite reticulitermes hesperus.bacillus cereus rw1 and serratia marcescens rw3, isolated from the hind-gut of the termite reticulitermes hesperus, both grew well on mesquite wood and produced moderate amounts of carboxymethylcellulase. carboxymethylcellulose (cmc) gels were depolymerized rapidly by b. cereus rw1 and slowly by s. marcescens rw3. the depolymerization of cmc was ph and temperature sensitive. depolymerization of gels by growing cultures of b. cereus rw1 and the action of cell-free extracts of b. cereus rw1 on cmc ...1978418144
[comparative investigations on the efficiency of chlorine and ozone against bacteria and spores (author's transl)].this paper is concerned with the measurement of first order rate constants for the death of bacteria by chlorine and ozone. while the first order conditions for chlorine were achieved with the aid of a new instrument which works basing on the polarographic principle this was attained for ozone under steady state conditions. besides differences of species some different properties for both oxidants were found as far as their bactericidal efficiency is concerned. they are discussed in this paper.1978418606
heterologous transfection with bacteriophage phix174 dna: and improved system.a highly efficient and much more reproducible system for the heterologous transfection of several kinds of gram-negative bacterial spheroplasts with bacteriophage phix174 dna was established. by mild washing of the speroplasts, the efficiency of transfection of all non-host heterologous bacterial species tested increased one or more orders of magnitude in producing the progeny phages and/or the infectious intermediates. using the improved heterologous transfection systems, it has become clearer ...1978418813
helical structure of the human umbilical cord.the helical structure of the human umbilical cord has been studied on 528 full-term cords from normal deliveries, 18 cords from aborted and developmentally normal fetuses with a cr length of 1.2-19.5 cm, 10 cords from monozygotic twins. in order to resolve the discrepancy in the nomenclature of the twist direction, a method has been suggested which takes into account the direction to which the fetus must have rotated to produce the twist. the incidence of the right helical pattern was 64.58%, of ...1979419931
the influence of dietary carbohydrate and fat on kidney calcification and the urinary excretion of n-acetyl-beta-glucosaminidase (ec 1979420762
[use of a laser photometer to determine blood platelet shape and aggregation in a flowing system].the paper treats of an original device for studies with the photometric method of the platelets shape and of their aggregation and disaggregation processes in the flow. experiments on the stenosed vessel model showed that in the presence of adp stenosis potentiated the platelets aggregation in the rabbit platelet-rich plasma.1979420923
bl-s786 (ceforanide), a new parenteral cephalosporin: in vitro (ceforanide) is a new cephalosporin which showed broad-spectrum activity in vitro against 453 clinical isolates. at a concentration of 3.12 mug/ml, it inhibited greater than 75% of isolates of escherichia coli, klebsiella spp., proteus mirabilis, staphylococcus aureus, streptococcus pyogenes, and streptococcus pneumoniae. essentially no activity was observed against isolates of serratia marcescens, and only minimal activity was observed against enterobacter spp. its activity was directly ...1979426520
human liver pi-alcohol dehydrogenase: kinetic and molecular properties. 1979427099
phospholipids of epidermophyton floccosum. 1979429049
synthesis and biological effect of the c-terminal pentapeptide amide of avian pancreatic hormone iii (app).model building studies and analogies drawn from peptides of similar biological activity have indicated that the c-terminus of avian pancreatic hormone iii may possess significant biological information. to test this hypothesis, the c-terminal pentapeptide amide sequence has been synthesized by the merrifield method. the synthesis, purification and characterization of this compound are reported here in detail. in vivo studies indicate that this synthetic segment possesses none of the secretogogic ...1979429096
effect of dietary proteins on the turnover of rat liver argininosuccinate synthetase.the rates of synthesis and degradation of arginosuccinate synthetase in rat liver under various dietary conditions were determined. the relative rate of the enzyme synthesis in the livers of rats fed on 70% casein diet was 4.0 times greater than that for rats fed on 5% casein diet. the rate constants of degradation (kd of argininosuccinate synthetase were estimated to be 0.15 and 0.16 day-1 under 70% and 5% casein feeding, respectively. when the dietary conditions were changed acutely from 70% t ...1979429260
messenger rna content and complexity of euthyroid and hypothyroid rat liver. 1979429284
a glucosylated oligosaccharide lipid intermediate in calf brain. evidence for the transfer of the oligosaccharide into membrane glycoprotein and subsequent removal of glucosyl residues. 1979429306
regulation of the hydroxylation of 25-hydroxyvitamin d3 in vivo and in primary cultures of chick kidney cells. 1979429315
toxicity of o,o,s-trimethyl and triethyl phosphorothioate to the rat. 1979429700
nosocomial klebsiellas. i. colonization of hospitalized patients.the colonization of patients by klebsiella and several other gram-negative bacteria was studied in a hospital urological ward over a period of six months. before and during the survey there was no evidence of an outbreak of nosocomial infection and multi-drug resistant strains of klebsiella were not isolated. klebsiella were biotyped by nine biochemical tests, which led to the detection of 66 biotypes spread uniformly throughout the survey period. this method of biotyping proved a useful epidemi ...1979429785
serum concentrations of testosterone, oestrogens, luteinizing hormone and follicle-stimulating hormone in male and female rats during the critical period of neural sexual differentiation.untreated male and female rat pups were killed 1--5 days post partum and the serum concentrations of testosterone, oestrogens, lh and fsh were determined by radioimmunoassay. at all five sampling times, the serum concentrations of testosterone in male rats were about three times higher than those in female rats, but serum levels of oestrogens did not differ between the sexes. serum concentrations of lh and fsh were lower in male than in female pups. in another study, rats were decapitated 1--10 ...1979429945
effect of bethanechol, gastrin i, or cholecystokinin on myoelectrical activity.the purpose of this study was to determine the effect of bethanechol, gastrin i, or the octapeptide of cholecystokinin (cck-op) on the smooth muscle of the isolated cat colon. myoelectrical activity was recorded with monopolar glass-pore electrodes. slow-wave frequency was 5.9 +/- 0.2 cycles/min during the basal period. slow waves were generally coupled during the control period and the apparent propagation velocity was predominantly aborad at a velocity of 3.8 +/- 0.4 mm/s. spike activity was s ...1979434201
voltage dependence of calcium transport in the thick ascending limb of henle's loop.thick ascending limbs of henle's loop were dissected from rabbit kidneys and perfused in vitro. unidirectional transepithelial calcium fluxes from lumen-to-bath and bath-to-lumen were measured with 45ca using different solutions that caused the transepithelial voltage to vary over a wide range. with lumen-positive voltages there was net calcium absorption from lumen to bath which varied directly with the voltage. with voltage near zero there was no measurable net flux. when the voltage was made ...1979434209
[pharmacokinetics and clinical studies on cs-1170 (author's transl)].the authors have carried out the pharmacokinetics and clinical studies of cs-1170. the results were as follows; cs-1170 was given by drip infusion for 1 hour dose of 20 mg per kg body weight to 3 children. the maximum blood level was reached at one hour after drip infusion. this blood levels were 38 micrograms/ml, 68 micrograms/ml and 86 micrograms/ml, respectively, (mean 64 micrograms/ml), and level at 2 hours, 11.5 micrograms/ml, 9.4 micrograms/ml, 16 micrograms/ml respectively, (mean 12.3 mic ...1979439393
the development of experimental brain tumours. a sequential light and electron microscope study of the subependymal plate. i. early lesions (abnormal cell clusters).pregnant bd-ix rats were given a single intraperitoneal injection of 30 mg of n-ethyl-n-nitrosourea (enu) per kg of body weight on the 15th day of gestation. the offspring were killed at fortnightly intervals between 2 and 20 weeks of age. the subependymal plate region adjacent to the lateral ventricles was examined by light and electron microscopy to study the early stages in the development of brain tumours. abnormal clusters of undifferentiated subpendymal plate cells were found in regions aw ...1979442982
mechanism of the fatty liver induced by cycloheximide and its reversibility by adenosine. 1979444306
effects of vitamin e and selenium deficiency on the fatty acid composition of rat retinal tissues.the fatty acid composition of retinal tissues was measured in rats maintained for 26--32 weeks on each of the following diets: a purified basal diet deficient in alpha-tocopherol and selenium, an identical control diet supplemented with alpha-tocopherol and selenium, and a commerical laboratory rat chow. dietary deficiencies of antioxidant nutrients were found to cause a large decrease in total polyunsaturated fatty acids in the retinal pigment epithelium, a small decrease in the retinal rod out ...1979444506
alanine metabolism in skeletal muscle in tissue culture.alanine production by skeletal muscle in tissue culture was studied using an established myogenic line (l6) of rat skeletal muscle cells. correlation analyses were performed on rates of metabolism of alanine, glucose, lactate and pyruvate over incubation periods up to 96 h. alanine production did not correlate significantly with glucose utilization (r = 0.24, p less than 0.20). alanine production, however, did correlate with lactate production (r = 0.72, p less than 0.0005) as well as medium (r ...1979444590
[role of structural rearrangements in the synthesis of atp in mitochondria]. 1979444624
distribution of iron between the binding sites of transferrin in serum: methods and results in normal human subjects.when it is incompletely saturated with iron, transferrin may exist in four molecular forms: apotransferrin, monoferric (a) transferrin (with iron occupying only the a site of the protein), monoferric (b) transferrin, and diferric transferrin. by combining electrophoresis in urea-polyacrylamide gels with crossed immunoelectrophoresis using specific antihuman transferin antiserum, it is possible to display and estimate the concentration of each of these four forms in normal human serum. the distri ...1979444649
benzodiazepine metabolism in cultures of isolated hepatocytes and liver fragments of human fetus. 1979446265
treatment of the clinical syndrome of no visible oestrus: alternative schemes using prostaglandin f2 alpha. 1979452328
sensitivity of gentamicin-resistant enterobacteriaceae to cefamandole and cefoxitin.a collection of gentamicin-resistant enterobacteriaceae strains was significantly more resistant to cefamandole than a species-matched collection of gentamicin-sensitive organisms. cefamandole and gentamicin resistance could be simultaneously transferred by conjugation from four different species, citrobacter freundii, escherichia coli, klebsiella pneumoniae and serratia marcescens, to a recipient e. coli strain. plasmids specifying linked resistance to cefamandole and gentamicin are thus common ...1979456076
specific vs nonspecific factors in psychotherapy. a controlled study of outcome.this study explored the relative contribution of the therapist's technical skills and the qualities inherent in any good human relationship to outcome in time-limited individual psychotherapy. highly experienced psychotherapists treated 15 patients drawn from a relatively homogeneous patient population (male college students, selected primarily on the basis of elevations on the depression, anxiety, and social introversion scales of the minnesota multiphasic personality inventory). by traditional ...1979475546
partial trisomy for the long arm of chromosome 7 due to familial balanced translocation.a partial trisomy for the distal segment of the long arm of chromosome 7 (bands q32 replaced by qter) was observed in a severely retarded child with somatic and cns anomalies. the phenotypically normal father and paternal grandmother had a balanced reciprocal translocation between the long arm of a chromosome 2 and the long arm of a chromosome 7: 46,xx-xy,t(2;7) (q37;q32). the clinical features of the child at birth and at the ages of 5 months and 2 years are compared with those previously repor ...1979478537
morphometric observations on the effects of ischemia in the isolated perfused rat heart. 1979480363
an xyy man.this case report describes a young man with a 47, xyy karyotype who was convicted of arson. he suffered from a cardiac disorder which may well have been part of the xyy syndrome rather than a chance association. his abnormal karyotype was disclosed in court and used by the defence in a plea in mitigation.1979497632
in vitro activity of ly127935.the activity of ly127935, a beta-lactam antibiotic of novel structure, was studied in vitro against facultative gram-negative bacilli, staphylococcus aureus, and bacteroides fragilis. the strains were recent clinical isolates, many of which were relatively resistant to other antibiotics. ly127935 exhibited striking activity against escherichia coli, klebsiella pneumoniae, enterobacter sp., proteus sp., serratia marcescens, and b. fragilis with median minimum inhibitory concentrations of less tha ...1979507785
a nuclear precursor to human gamma-globin messenger rna.rna isolated from human foetal liver at an erythroid stage of development was transferred from methyl mercury hydroxide agarose gels to diazobenzyloxymethyl paper. a 16s rna species containing gamma-globin mrna sequences was identified by hybridisation to 32p-labelled human gamma-globin cdna recombinant plasmid phgamma gi. this rna is found only in the cell nucleus and is polyadenylated. human globin gene transcription is thus analagous to that in mouse: interventing sequences are transcribed an ...1979514808
inhibition of drug oxidation and stimulation of nadph oxidase in vitro by doxorubicin and triferric-doxorubicin.the electrophilic properties of the quinone-hydroquinone configuration of anthracycline antibiotics suggests a possible influence on cytochrome p-450-mediated mono-oxygenase reactions. both doxorubicin and triferric-doxorubicin (a derivative in which the quinone groups are blocked with iron) showed a similar dose-dependent inhibition of liver microsomal drug metabolism. a doxorubicin concentration-related stimulation of nadph oxidase activity was found to be linear but that for triferric-doxorub ...1979515168
spinal analgesia and sedation of goats with lignocaine and xylazine.spinal anaesthesia of 20 does undergoing laparotomies was accomplished with epidural injections of 2 per cent lignocaine at a dosage of 1 ml per 4.55 kg in 16 goats. epidural injection resulted in paralysis lasting 198.5 minutes +/- 36.6 minutes. subarachnlid injection resulted in paralysis lasting 180.8 minutes +/- 44.9 minutes. xylazine was given intramuscularly at the dosage of 0.11 mg per kg after posterior paralysis was complete. these treatments resulted in effective analgesia for surgical ...1979516312
[on the stiffness of human tibialis anterior muscle during voluntary contraction (author's transl)]. 1979522295
[problems of the disease due to mycobacteria other than tubercle bacilli: surgical treatment and indication (author's transl)]. 1979522352
insulin responsiveness of adipose tissue from normal weight subjects with early normal weight subjects, classified by a 2-h glucose infusion test as having normal (11), borderline (3) or pathological (9) carbohydrate tolerance (cht), subcutaneous adipose tissue was removed under intracutaneous anesthesia by surgical biopsy. the biological responsiveness of isolated adipocytes as well as adipose tissue fragments measured as incorportion of (1-14c) glucose into co2 or triglycerides was studied in the absence or presence of different insulin concentrations. in persons with ...1979525210
ceftizoxime (fk 749), a new parenteral cephalosporin: in vitro and in vivo antibacterial 749 is a new parenteral cephalosporin derivative which is more active against various gram-negative bacilli, including the opportunistic pathogens such as enterobacter, citrobacter species, and serratia marcescens, than cephalosporins and cephamycins such as cefotiam, cefamandole, cefuroxime, cefotaxime, and cefmetazole. fk 749 was especially active against gram-negative organisms resistant to these related antibiotics. fk 749 was more potent in bactericidal activity than the other antibiotic ...1979525994
ly127935, a new beta-lactam antibiotic, versus proteus, klebsiella, serratia, and hundred eight clinical isolates of proteus, klebsiella, serratia, and pseudomonas spp. were tested in vitro against ly127935, cefamandole, cefoxitin, ticarcillin, carbenicillin, gentamicin, tobramycin, and amikacin by broth microdilution. the activities of ly127935 were greater than or equal to those of the other antimicrobial agents against proteus vulgaris, klebsiella pneumoniae, and serratia marcescens. inhibitions were greatest, however, for ticarcillin and carbenicillin versus proteus m ...1979526006
lateral interactions in human cone dark adaptation.1. the course of cone dark adaptation after exposure to a strong bleaching light depends on the size of the bleached region. threshold for brief, tiny test flash centred in the bleached region is elevated more, and recovery is retarded by a small bleach. this effect has its parallel in the sensitization effect observed with steady backgrounds. 2. previous results, that a similar sensitization effect is not observed in rod dark adaptation, are confirmed. 3. this sensitization effect in cone dark ...1979529074
radiotelemetric measurement of normal human small bowel motor activity during prolonged fasting [proceedings]. 1979529126
responses of supraoptic neurones to local hypertonic saline in the rat [proceedings]. 1979529135
effect of disinfectants with and without usage of detergent for the flexible fiberoptic bronchoscope.the purpose of this study was to find a safer, more rapid and easier disinfection process for the flexible fiberoptic bronchoscope (f.f.b.) by using ordinary disinfectants and a detergent. klebsiella pneumoniae, pseudomonas aeruginosa, staphylococcus aures, e. coli, serratia marcescens and candida albicans were used as sources of contamination. the mixed bacterial growth preparations for contamination of the f.f.b. were the same as those previously mentioned in our study. comparative bacteriolog ...1979529489
fortimicin a: collaborative in vitro susceptibility. comparison with amikacin and gentamicin against 11,840 clinical bacterial isolates.the susceptibility of 11,840 clinical bacterial isolates to fortimicin a was determined by agar dilution or broth microdilution methods and compared with their susceptibility to amikacin and gentamicin. in general, the in vitro activity of fortimicin a was essentially the same as that of amikacin. significant exceptions were the increased effectiveness of fortimicin a against serratia marcescens and the greater activity of amikacin against pseudomonas and other nonfermentative gram-negative baci ...1979533262
in vitro activity of ly127935, a new 1-oxa cephalosporin, against aerobic gram-negative bacilli.a total of 434 clinical aerobic gram-negative bacillary isolates were tested against ly127935, a new 1-oxa cephalosporin, and compared with other cephalosporins, penicillins, and aminoglycosides by a broth microdilution technique. cefotaxime (hr756), a new semisynthetic cephalosporin, and ly127935 were more active, and showed lower minimum inhibitory concentrations (ranges, less than or equal to 0.12 to 2.0 micrograms/ml), than cefamandole, cefoxitin, and cefazolin against escherichia coli, kleb ...1979533267
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