Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| electrophoretic analysis of salmonella typhi and other bacteria. | a comparative study involving sds-page of salmonella typhi and other bacteria was conducted. protoplasmic antigens of salmonella typhi. salmonella paratyphi a, salmonella typhimurium, proteus sp, klebsiellas sp. pseudomonas aeruginosa, shigella flexneri, staphylococcus aureus were separated and compared on sds-page followed by checking of their cross reactivity by gel diffusion using antisera raised against whole cell and lysates of salmonella typhi. lines of identity between salmonella typhi, s ... | 2002 | 12649947 |
| somatic gene mutation and human disease other than cancer. | while the focus of much mutation research is on germ-line mutation, somatic mutation is being found to be important in human disease. neurofibromatosis 1 and mccune-albright are disorders which are detected in the skin and other systems. the skin manifestations were essential for the demonstration of somatic mosaicism in neurofibromatosis 1, while analysis of blood dna demonstrated somatic mutation in neurofibromatosis 2. incontinentia pigmenti is also a disorder seen in skin and other tissues, ... | 2003 | 12644182 |
| rheumatoid arthritis: proposal for the use of anti-microbial therapy in early cases. | rheumatoid arthritis (ra) is a chronic disease, affecting women more than men, especially in those possessing the "shared epitope" (eqk/rraa) amino acid sequences present in hla-dr1/4 molecules. proteus mirabilis carries sequences showing molecular mimicry to the "shared epitope" and to type xi collagen of hyaline cartilage. elevated levels of antibodies to p. mirabilis have been reported from 14 different countries involving 1375 ra patients and the microbe has been isolated from urine cultures ... | 2003 | 12635939 |
| a uk multicentre study of the antimicrobial susceptibility of bacterial pathogens causing urinary tract infection. | to determine the prevalence of resistance amongst urinary tract pathogens against antimicrobials used to treat urinary tract infections (utis) in the uk to provide data to help direct empirical therapy. | 2003 | 12634070 |
| a survey of bacterial diversity in ticks, lice and fleas from australia. | we isolated bacteria from ticks, lice and fleas. partial small subunit rrna sequences were obtained for each isolate and the closest matches in the fasta database were determined. these bacteria were mostly gram-positive (firmicutes), although representatives from the proteobacteria (alpha, beta, gamma subdivisions) and cfb group were also isolated. most of the isolates we found were from genera that were present in most of the ectoparasites studied, but a few genera were restricted to one speci ... | 2003 | 12632173 |
| pathogenic intestinal parasites and bacterial agents in solid wastes. | to determine the profile of potentially pathogenic enteric parasites and bacterial agents in municipal refuse dumps in ibadan, nigeria. | 2002 | 12630495 |
| [bacteriological monitoring of infective agents of purulent septic diseases in an emergency hospital]. | during the period of 1995-2001 bacteriological examination of 13,842 patients with purulent septic diseases (psd) was carried out. the statistical processing of data revealed that equalization of the dynamic rows of intensive and extensive values characterizing the number of patients with psd caused by etiologically important infective agents made it possible to evaluate the reliability of information. a trend to increased etiological importance of the genera pseudomonas, escherichia and klebsie ... | 2003 | 12630345 |
| serologic evidence of human infection by francisella tularensis in the population of castilla y león (spain) prior to 1997. | prior to an outbreak in castilla y león in december 1997, tularaemia was practically non-existent in spain. in this paper we studied the prevalence of antibodies against francisella tularensis in a representative sample of the population (4825 people) from castilla y león (spain) in samples collected before this outbreak. antibodies against f. tularensis were detected in nine (0.19%) of the 4825 sera, with antibody titres ranging from 1/20 to 1/160. of these nine sera, one was positive in seroag ... | 2003 | 12628554 |
| antimicrobial activity of ximenia americana. | extracts of the bark, leaves, root and stem of ximenia americana were tested for their antimicrobial and antifungal activity. | 2003 | 12628405 |
| antimicrobial susceptibility of gram-negative uropathogens isolated from obstetric patients. | to evaluate the antimicrobial susceptibility of gram-negative uropathogens isolated from pregnant women. | 2002 | 12625967 |
| pathogenic agents of chronic suppurative otitis media in ilorin, nigeria. | to determine the type and pattern of antibiotic susceptibility of the pathogenic micro-organisms causing chronic suppurative otitis media (csom) in our environment. | 2002 | 12625677 |
| r-factor in proteus vulgaris from ulcerative disease of fish, channa punctatus. | a proteus vulgaris isolated from external ulcers of the fresh water fish channa punctatus showed multidrug resistance and heavy metal tolerance. the isolate from the ulcer showed resistance to chloramphenicol (ch), nalidixic acid (nx), streptomycin (str) and tetracycline (tet) with minimum inhibitory concentration (mic) values of 750, 150, 75 and 125 microg/ml, respectively. the isolate showed growth in medium containing cadmium (cd2+), up to a concentration of 2.5 mm indicating its heavy metal ... | 2002 | 12622213 |
| [antibacterial activity of cefpodoxime against clinical isolates in 2000 and 2001]. | as the post-marketing surveillance of cefpodoxime proxetil (banan), mics of cefpodoxime (cpdx, an active form of banan) against 1090 clinical isolates of 22 species from 15 medical institutions all over japan from june 2000 to march 2001 were measured using the broth microdilution method approved by the japanese society of chemotherapy and compared with those of oral cephem antibacterials, cefaclor, cefdinir, cefditoren, and cefcapene. in this study, remarkable change in the activity of cpdx was ... | 2002 | 12621736 |
| bmp2 exposure results in decreased pten protein degradation and increased pten levels. | the tumour suppressor gene pten encodes a dual-specificity phosphatase that recognizes protein and phosphatidylinositiol substrates and modulates cellular functions such as migration and proliferation. germline mutations of pten have been shown to cause cowden syndrome, bannayan-riley-ruvalcaba syndrome and proteus syndrome. recently, germline mutations in bmpr1a, the gene encoding the type 1a receptor of bone morphogenetic proteins (bmp) have been found in rare families with cowden syndrome, su ... | 2003 | 12620973 |
| vitreous and aqueous penetration of orally administered gatifloxacin in humans. | to investigate the penetration of gatifloxacin, a novel extended-spectrum fourth-generation fluoroquinolone antibiotic, into the vitreous and aqueous humor after oral administration. | 2003 | 12617704 |
| bile cultures and sensitivity patterns in malignant obstructive jaundice. | bactibilia is one of the important factors in the development of postoperative septic complications. we undertook this retrospective analysis to identify the organisms present in bile and their antibiotic susceptibility patterns in patients with malignant obstructive jaundice. | 2003 | 12617446 |
| [prevalence of antibodies against francisella tularensis in castilla y león (spain) before 1997]. | the aim of this paper was determine the prevalence of antibodies against francisella tularensis in the representative sample of people from castilla-león (spain) before epidemic outbreak of end 1997. | 2003 | 12605730 |
| the etiology of urinary tract infection: traditional and emerging pathogens. | the microbial etiology of urinary infections has been regarded as well established and reasonably consistent. escherichia coli remains the predominant uropathogen (80%) isolated in acute community-acquired uncomplicated infections, followed by staphylococcus saprophyticus (10% to 15%). klebsiella, enterobacter, and proteus species, and enterococci infrequently cause uncomplicated cystitis and pyelonephritis. the pathogens traditionally associated with uti are changing many of their features, par ... | 2003 | 12601338 |
| proteus syndrome: a concern for the anesthesiologist. | 2003 | 12598301 | |
| development of resistant bacteria isolated from dogs with otitis externa or urinary tract infections after exposure to enrofloxacin in vitro. | minimum inhibitory concentrations for enrofloxacin were determined for 63 bacterial isolates from dogs with otitis externa or urinary tract infections. development of resistant mutants was determined after exposing the isolates to enrofloxacin in vitro for up to five serial passages. results indicated that pseudomonas aeruginosa and enterococcus spp isolates exposed to enrofloxacin developed resistance rapidly, whereas klebsiella, proteus, and streptococcus spp were less likely to develop resist ... | 2002 | 12584687 |
| [second multicenter study of the in vitro susceptibility to piperacillin-tazobactam]. | a study was conducted in 1999 on the activity of piperacillin-tazobactam on 1349 strains collected in a spanish multicenter study involving 10 hospitals. a total of 897 gram-negative bacteria of the following genuses were collected: escherichia coli (169), klebsiella spp. (112), pseudomonas spp. (122), enterobacter spp. (92), serratia spp. (44), citrobacter spp. (37), proteus spp. (114), morganella spp. (49), acinetobacter spp. (47), stenotrophomonas spp. (47), haemophilus spp. (45), moraxella s ... | 2002 | 12582446 |
| motility of three strains of proteus mirabilis (g9, p11 and pm5c) in liquid suspension under different environmental conditions. | the effect of compounds on the motility of proteus mirabilis swarmer cells varies from one strain to another. the effect of compounds on the motility of swarmer cells is mainly at higher concentrations than the concentration used to inhibit swarming. boric acid only affects the motility of strain g9 swarmer cells, whereas sodium deoxycholate prevented the motility of swarmer cells for three strains. some antibiotics show their effect on the motility of swarmer cells in anaerobic areas, by slowin ... | 2003 | 12578309 |
| randomized prospective comparative study: short-term treatment with ciclopiroxolamine (cream and solution) versus boric acid in the treatment of otomycosis. | sixty-four patients with symptomatic otomycosis (80 infected ears) confirmed by direct microscopy and culture were randomly treated for i week with ciclopiroxolamine cream 11% (group a, 20 infected ears, 17 patients), ciclopiroxolamine solution 1% (group b, 20 infected ears, 17 patients) and boric acid (group c, 40 infected ears, 30 patients) and daily mechanical suction aspiration of the debris. an attempt was made to match 11 clinical parameters with both the mycological and bacteriological fi ... | 2002 | 12572722 |
| the role of conjugative transposons in the enterobacteriaceae. | although widely studied in gram-positive streptococci and in the gram-negative bacteroides, there is a scarcity of information on the occurrence and nature of conjugative transposon-like elements in the well-studied enterobacteriaceae. in fact, some of the major reviews on conjugative transposons prior to 1996 failed to mention their occurrence in this group. recently, their presence has been reported in salmonella, vibrio and proteus species, and in some cases such as the sxt element in vibrio ... | 2002 | 12568331 |
| essential oil composition and antimicrobial activity of santiria trimera bark. | the composition and the antimicrobial activity of the bark oil of santiria trimera (oliv.) aubrév., a plant widely used by the traditional healers in s. tomé and príncipe, especially for wound healing, are reported for the first time. the analysis of the essential oil was carried out by gc and gc-ms. the oil contains a high content of monoterpenes, alpha-pinene (66.6 %) being the major constituent, followed by beta-pinene (20.0 %). the essential oil was active against both bacteria and fungi str ... | 2003 | 12567287 |
| [tartrate-resistant acid phosphatase in free-living amoeba proteus]. | tartrate-resistant acid phosphatase (trap) of amoeba proteus (strain b) was represented by 3 of 6 bands (= electromorphs) revealed after disc-electrophoresis in polyacrylamide gels with the use of 2-naphthyl phosphate as a substrate at ph 4.0. the presence of mgcl2, cacl2 or zncl2 (50 mm) in the incubation mixture used for gel staining stimulated activities of all 3 trap electromorphs or of two of them (in the case of zncl2). when gels were treated with mgcl2, cacl2 or zncl2 (10 and 100 mm, 30 m ... | 2002 | 12561734 |
| mental deficiency, alterations in performance, and cns abnormalities in overgrowth syndromes. | mental deficiency, alterations in performance, and central nervous system (cns) abnormalities are discussed in the following overgrowth syndromes: sotos syndrome, weaver syndrome, proteus syndrome, neurofibromatosis type 1, fragile x syndrome, syndromes with neonatal hypoglycemia, simpson-golabi-behmel syndrome, hemihyperplasia, sturge-weber syndrome, bannayan-riley-ruvalcaba/cowden syndrome, macrocephaly-autism syndrome, peho syndrome, chromosomal syndromes, and other miscellaneous syndromes. | 2003 | 12561058 |
| pathogenic colonization of oral flora in frail elderly patients fed by nasogastric tube or percutaneous enterogastric tube. | aspiration of infected oropharyngeal content is the main cause of aspiration pneumonia. this complication, mainly related to gram-negative bacteria, threatens percutaneous enterogastric tube as well as nasogastric tube (ngt) fed patients. the objective of this study was to examine the oral microbiota of tuboenterally fed patients and compare it with that of orally fed counterparts. | 2003 | 12560411 |
| structure of the o-specific polysaccharide of proteus vulgaris o45 containing 3-acetamido-3,6-dideoxy-d-galactose. | an o-specific polysaccharide was isolated by mild acid degradation of the lipopolysaccharide of proteus vulgaris o45 and studied by sugar and methylation analyses along with 1h and 13c nmr spectroscopy, including 2d cosy, tocsy, roesy, h-detected 1h,13c hsqc and hmbc experiments. the following structure of the pentasaccharide repeating unit of the polysaccharide was established:-->6)-alpha-d-glcpnac-(1-->4)-alpha-d-galpnac-(1-->4)-alpha-d-galpa-(1-->3)-beta-d-glcpnac-(1-->2)-beta-d-fucp3nac4ac-( ... | 2003 | 12559730 |
| proteus syndrome: a case with clonal chromosome aberration. | proteus syndrome is a disorder characterized by overgrowth of multiple tissues, connective tissue nevi, epidermal nevi and hyperostoses with asymmetric involvement. the clinical expression of the disorder is extremely variable. molecular pathogenesis of the syndrome is unknown but it is hypothesized that it resulted from a somatic alteration of a gene leading to mosaic effects that would be lethal if the mutation was carried in nonmosaic fashion, and this may explain the variability among patien ... | 2002 | 12558113 |
| [a study on the determination method of biological function of brf]. | this study was aimed to establish a method for determining the biological function of biological wave regulating factor (brf). proteus mirabilis was used to set up the experimental model. the biological function of the component obtained from wave growth media beneath the bacterial colony rings resulting from bacterial proliferation was determined in biological wave test by analytically microbiological method. the results indicated that brf could enhance biological wave and shorten its period. t ... | 2000 | 12557788 |
| vitreous penetration of orally administered gatifloxacin in humans. | to investigate the penetration of gatifloxacin, a novel extended-spectrum fluoroquinolone antibiotic, into the vitreous humor after oral administration. | 2002 | 12545689 |
| acrab multidrug efflux pump is associated with reduced levels of susceptibility to tigecycline (gar-936) in proteus mirabilis. | tigecycline has good broad-spectrum activity against many gram-positive and gram-negative pathogens with the notable exception of the proteeae: a study was performed to identify the mechanism responsible for the reduced susceptibility to tigecycline in proteus mirabilis. two independent transposon insertion mutants of p. mirabilis that had 16-fold-increased susceptibility to tigecycline were mapped to the acrb gene homolog of the escherichia coli acrrab efflux system. wild-type levels of decreas ... | 2003 | 12543675 |
| [the clinical investigation of bacteriology of chronic suppurative otitis media]. | to understand bacteriology of chronic suppurative otitis media (csom) and drug sensitivity of isolated bacteria for better treatment of csom. | 2001 | 12541726 |
| urer, the transcriptional activator of the proteus mirabilis urease gene cluster, is required for urease activity and virulence in experimental urinary tract infections. | proteus mirabilis, a cause of complicated urinary tract infection, produces urease, an essential virulence factor for this species. urer, a member of the arac/xyls family of transcriptional regulators, positively activates expression of the ure gene cluster in the presence of urea. to specifically evaluate the contribution of urer to urease activity and virulence in the urinary tract, a urer mutation was introduced into p. mirabilis hi4320 by homologous recombination. the isogenic urer::apha mut ... | 2003 | 12540589 |
| [antibacterial activities and pk/pd parameters of aminoglycosides against recent clinical isolates of gram-negative rods]. | we examined antibacterial activities and pk/pd parameters of six kinds of aminoglycosides against seven bacterial species of clinical isolates in 2001. aminoglycoseides examined were gentamicin (gm), dibekacin (dkb), tobramycin (tob), amikacin (amk), netilmicin (ntl), and isepamicin (isp), and bacterial isolates used were each 50 strains of escherichia coli, klebsiella pneumoniae, enterobacter cloacae, citrobacter freundii, proteus spp., serratia marcescens and pseudomonas aeruginosa. all aminog ... | 2002 | 12532635 |
| lipopolysaccharide from proteus mirabilis o29 induces changes in red blood cell membrane lipids and proteins. | alterations in red blood cell (rbc) plasma membranes, i.e. in lipids and proteins, and osmotic fragility of these cells after treatment with proteus mirabilis o29 endotoxin (lipolysaccharide (lps)) were examined using a spin labelling method. at the highest concentration of lps, insignificantly decreased fluidity of membrane lipids was observed. changes in conformation of membrane proteins were determined by two covalently bound spin labels, 4-maleimido-2,2,6,6-tetramethylpiperidine-1-oxyl (msl) ... | 2003 | 12531246 |
| [comparative population study of the etiological role of causative agents of purulent inflammatory diseases and serum antibodies to antigens of opportunistic microorganisms]. | the comparative study of the relationship between the levels of serum antibodies to the antigens of opportunistic microorganisms of 5 genera (pseudomonas, proteus, staphylococcus, klebsiella, escherichia) and the microbial status was carried out. a total of 854 patients from 10 profile departments of a surgical hospital were examined. population analysis and statistical methods of processing the results of the examination of 353 practically healthy subjects and 268 blood and plasma donors permit ... | 2002 | 12524998 |
| prevalence of asymptomatic bacteriuria among pregnant women in benin city, nigeria. | a semi-quantitative screening for asymptomatic bacteriuria was carried out in the first trimester of 500 consecutive pregnant women in benin city. the purpose was to provide baseline data and rational therapy for asymptomatic bacteriuria in pregnant women. of the 500 women screened, 433 clinical specimens showed significant bacteriuria, representing an incidence of 86.6%. of this number, 38 (7.4%) were of mixed bacterial colonies while 395 (91%) were of single bacterial colonies. staphylococcus ... | 2001 | 12521882 |
| studies of certain factors affecting the microenvironment and microflora of the external ear of the dog in health and disease. | a total of 187 dogs, 110 with clinical signs of otitis externa (oe), and 77 without history or clinical signs of oe, were examined microenvironment and microbiological analysis of their ear exudates made. the aural temperature and humidity of 160 dogs were measured. there were no significant difference between healthy dogs and oe dogs. german shepherd showed relatively lower temperature (p<0.01) and higher humidity (p<0.01). the mean log(10) number of microbial organisms of ears of oe dogs (4.16 ... | 2002 | 12520110 |
| contamination levels of in-use disinfectants in a teaching hospital in lagos, nigeria. | in-use testing of the disinfectants; hibitane (5% w/v chlorhexidinegluconate), hibiscrub (4% w/v chlorhexidinegluconate), savlon (3% w/v chlorhexidine/cetrimide), hydrogen peroxide (6% w/v hydrogen peroxide with stabilizer) and a common household bleach jik (3.5% w/v sodium hypochlorite), was carried out over a two-month period at a university teaching hospital in nigeria. contamination levels were high with 82 (63.1%) of the 130 in-use disinfectants contaminated. however, a few of the stock sol ... | 2002 | 12518903 |
| evaluation of a novel automated chemiluminescent assay system for antimicrobial susceptibility testing. | the newly developed rapid lumi eiken/is60 (rl/is60) system automatically determines mics by detecting chemiluminescence produced in the reaction of a chemiluminescent probe and oxygen metabolites from living microorganisms. the present study evaluated this system for accuracy in antimicrobial susceptibility testing. chemiluminescence intensities after 4 h of cultivation of clinically important strains were plotted against various concentrations of antimicrobial agents, which resulted in curves r ... | 2003 | 12517861 |
| occurrence and phenotypic characteristics of extended-spectrum beta-lactamases among members of the family enterobacteriaceae at the tel-aviv medical center (israel) and evaluation of diagnostic tests. | we assessed the prevalence and phenotypic characteristics of extended-spectrum beta-lactamase (esbl) producers among cefuroxime-resistant (cxm-r) (mic > or = 32 micro g/ml) members of the family enterobacteriaceae in our institution. the 438 cxm-r clinical isolates obtained from nonurine sources among inpatients were screened. esbl production was confirmed by disk diffusion assay using cefpodoxime (cpd), cefotaxime (ctx), and ceftazidime (ctz) with and without clavulanate (clav). a difference of ... | 2003 | 12517841 |
| [dynamics of antibiotic resistance of purulent septic pathogens at an emergency facility]. | the predominant pathogens at the emergency medicine hospital were analysed and its resistance to antibiotics was investigated in dynamics. the susceptibility of the pathogens was analysed by the method of dynamic equalibration. statistically significant reduction of resistant bacteria isolation was demonstrated for 2 species of 7--that is s. aureus and e. faecalis regarding 4 antibiotics. the ratio of staphylococci resistant to cefazolin, ceftazidime, doxycyclin reduced, the ratio of enterococci ... | 2002 | 12515091 |
| [pathogenicity islands in opportunistic enterobacteria]. | the presence of fragments of genomes hlya, hlyb, papah, papc, sfag, sfaa and kps mt, associated with the pathogenicity islands of escherichia coli, in clinical strains of other genera of the family enterobacteriaceae, has been experimentally evaluated with the use of pcr. the presence of dna fragments specific to the known genes of the pathogenicity clusters of e. coli in representatives of the genera citrobacter, enterobacter, hafnia, klebsiella, morganella, proteus, providencia, serratia and y ... | 2002 | 12506618 |
| antimicrobial activity of feiii, cuii, agi, znii and hgii complexes of 2-(2-hydroxy-5-bromo/nitro-phenyl)-1h- and 2-(2-hydroxyphenyl)-5-methyl/chloro/nitro-1h-benzimidazoles. | antimicrobial activity of 2-(2-hydroxyphenyl)-5-r5-1h-benzimidazoles, 2-(2-hydroxy-5-r5'-phenyl)-1h-benzimidazoles and their feiii, cuii, agi, znii and hgii nitrate complexes was tested toward staphylococcus aureus, staphylococcus epidermidis, escherichia coli, klebsiella pneumoniae, pseudomonas aeruginosa, salmonella typhi, shigella flexneri, and proteus mirabilis. antifungal activity was tested against candida albicans. benzimidazole benzene ring substituents increase the antimicrobial activit ... | 2002 | 12503391 |
| integration of a transposon tn1-encoded inhibitor-resistant beta-lactamase gene, bla(tem-67) from proteus mirabilis, into the escherichia coli chromosome. | proteus mirabilis nel-1 was isolated from a urine sample of a patient hospitalized in a long-term care facility. strain nel-1 produced a beta-lactamase with a pi of 5.2 conferring resistance to amoxicillin and amoxicillin-clavulanic acid. sequencing of a pcr amplicon by using tem-specific primers revealed a novel bla(tem) gene, bla(tem-67). tem-67 was an irt-1-like tem derivative related to tem-65 (lys39, cys244) with an additional leu21ile amino acid substitution in the leader peptide. the bioc ... | 2003 | 12499163 |
| evaluation of anti-diarrhoeal activity in seed extracts of mangifera indica. | mangifera indica is commonly grown in many parts of the world. its seeds have been used for anti-diarrhoeal activity in indian traditional medicine. this study evaluates the potential anti-diarrhoeal activity of methanolic (mmi) and aqueous (ami) extracts of seeds of m. indica in experimental diarrhoea, induced by castor oil and magnesium sulphate in mice. both mmi and ami were given orally in the dose of 250 mg/kg, showed significant anti-diarrhoeal activity comparable with that of the standard ... | 2003 | 12499070 |
| [amyloidosis associated with chronic granulomatous disease in a patient with a renal transplant and recurrent urinary tract infections]. | chronic granulomatous disease is a group of syndromes which share a defect in a component of the phagocyte nadph-oxidase complex. without this enzyme activity, phagocytic cells cannot produce superoxide, peroxide, and other potent microbicidal radicals, and are less able to kill ingested pathogens. the clinical picture is characterised by recurrent life-threatening bacterial and fungal infections and abnormal tissue granuloma formation. on the other hand, amyloidosis is a systemic disease with r ... | 2002 | 12497752 |
| on the involvement of the water-polaron mechanism in energy trapping by reaction centers of purple bacteria. | a locus for binding a mobile water molecule was searched for in the immediate vicinity of the special pair in the reaction center. using the proteus pc-program (a part of the grasp package) atomic structures of the reaction centers were analyzed in purple bacteria rhodopseudomonas viridis and rhodobacter sphaeroides. in both structures the loci for binding mobile water molecules were found at the distance of about 4.5 a from the middle of the special pair in the reaction center. the reorientatio ... | 2002 | 12495417 |
| an international survey of the antimicrobial susceptibility of pathogens from uncomplicated urinary tract infections: the eco.sens project. | the eco.sens study is the first international survey to investigate the prevalence and susceptibility of pathogens causing community-acquired acute uncomplicated urinary tract infections (utis). midstream urine samples were taken for culture and for testing for the presence of leucocytes from 4734 women not older than 65 years presenting with symptoms of acute uti at 252 community health care centres in 17 countries. recognized urinary tract pathogens were identified and the susceptibility to 12 ... | 2003 | 12493789 |
| structure of the o-specific polysaccharide of proteus vulgaris o15 containing a novel regioisomer of n-acetylmuramic acid, 2-acetamido-4-o-[(r)-1-carboxyethyl]-2-deoxy-d-glucose. | an acidic o-specific polysaccharide was obtained by mild acid degradation of the lipopolysaccharide of proteus vulgaris o15 and studied by sugar and methylation analyses along with 1h and 13c nmr spectroscopy, including 2d cosy, tocsy, roesy, and h-detected 1h,(13)c hmqc experiments. the polysaccharide was found to contain an ether of glcnac with lactic acid, and the following structure of the repeating unit was established:-->3)-alpha-d-glcpnac4(r-lac)6ac-(1-->2)-beta-d-glcpa-(1-->3)-alpha-l-6d ... | 2002 | 12493231 |
| urinary tract infection trends in latin american hospitals: report from the sentry antimicrobial surveillance program (1997-2000). | urinary tract infections (uti) are one of the most common infectious diseases diagnosed in outpatients as well as in hospitalized patients. the objective of this study was to report the frequency of occurrence and antimicrobial susceptibility of uropathogens collected in latin america between 1997 to 2000 through the sentry antimicrobial surveillance program. antimicrobial susceptibility testing was performed and results interpreted using reference broth microdilution methods. in the 4 year peri ... | 2002 | 12493177 |
| necrotizing gangrene of the genitalia and perineum. | necrotizing gangrene of the genitalia and perineum is a fulminant, life-threatening condition. this infection is usually polymicrobial and may be idiopathic or secondary to local trauma or surgery. histologically, it is characterized by obliterative endarteritis and thrombosis of the subcutaneous vessels, fascial necrosis, and leukocytic infiltration. mortality rates of 25-75% have been reported. most cases of necrotizing gangrene begin insidiously, with scrotal discomfort and malaise. later, er ... | 2002 | 12492967 |
| antimicrobial activity of psidium guajava l. | psidium guajava aqueous bark and methanolic extracts were found to possess anti-bacterial activity. | 2002 | 12490238 |
| role of rsma in the regulation of swarming motility and virulence factor expression in proteus mirabilis. | swarming by proteus mirabilis involves differentiation of typical short vegetative rods into filamentous hyper-flagellated swarm cells that undergo cycles of rapid and co-ordinated population migration across surfaces and exhibit high levels of virulence gene expression. rsma (repressor of secondary metabolites) and csra, its homologue in escherichia coli, control many phenotypic traits, such as motility and pathogenesis in erwinia species, glycogen biosynthesis, cell size and biofilm formation ... | 2003 | 12488561 |
| polysaccharide part of proteus mirabilis lipopolysaccharide may be responsible for the stimulation of platelet adhesion to collagen. | lipopolysaccharide (lps, endotoxin) is a well-known causative agent of septic shock and disseminated intravascular coagulation. the action of lps is related to the activation of many types of cells, including blood platelets. we examined the effects of different lpss from proteus mirabilis (smooth form lps s1959 and rough forms lpss r110 and r45) and fragments of lps structure (lipid a and polysaccharide part) on platelet adhesion to collagen in the presence or absence of the phoinositide 3-kina ... | 2002 | 12487790 |
| high-resolution structure and biochemical properties of a recombinant proteus mirabilis catalase depleted in iron. | heme catalases are homotetrameric enzymes with a highly conserved complex quaternary structure, and their functional role is still not well understood. proteus mirabilis catalase (pmc), a heme enzyme belonging to the family of nadph-binding catalases, was efficiently overexpressed in e. coli. the recombinant catalase (rec pmc) was deficient in heme with one-third heme and two-thirds protoporphyrin ix as determined by mass spectrometry and chemical methods. this ratio was influenced by the expres ... | 2003 | 12486720 |
| in vitro and in vivo pharmacodynamic properties of the fluoroquinolone ibafloxacin. | the pharmacodynamic properties of a new veterinary fluoroquinolone antimicrobial agent, ibafloxacin, were evaluated. minimal inhibitory concentrations (mic), time-kill kinetics, postantibiotic effect (pae) and postantibiotic subminimal inhibitory concentration effects (pa-sme) were determined against pathogenic canine gram-negative and gram-positive bacterial isolates from dermal, respiratory and urinary tract infections. the synergistic interactions between ibafloxacin and its main metabolite, ... | 2002 | 12485346 |
| antimicrobial activity of essential oils isolated from portuguese endemic species of thymus. | thymus species are wild species mostly found in the arid lands of portugal. possible antimicrobial properties of thymus essential oils have been investigated. the chemical composition of the essential oils and the antimicrobial activity of thymus mastichina (l) l. subsp. mastichina, t. camphoratus and t. lotocephalus from different regions of portugal were analysed. | 2003 | 12485339 |
| in vitro activity of gemifloxacin against recent clinical isolates of bacteria in korea. | gemifloxacin is an enhanced-affinity fluoroquinolone with broad-spectrum antibacterial activity. in korea, resistant bacteria are relatively more prevalent than in other industrialized countries. in this study, we studied the in vitro activities of gemifloxacin, gatifloxacin, moxifloxacin, levofloxacin, ciprofloxacin, and other commonly used antimicrobial agents against 1,689 bacterial strains isolated at four korean university hospitals during 1999-2000. minimum inhibitory concentrations (mics) ... | 2002 | 12482994 |
| susceptibility of antibiotic-resistant gram-negative bacteria to biocides: a perspective from the study of catheter biofilms. | bacteria resistant to both the agents deployed to prevent infections and those used to treat infections would be formidable nosocomial pathogens. the aim of this paper is to review the evidence that gram-negative bacteria resistant to antibiotics and biocides have emerged and been responsible for catheter-associated urinary tract infection. a study of patients undergoing intermittent bladder catheterization revealed that the frequent application of the antiseptic chlorhexidine to the perineal sk ... | 2002 | 12481841 |
| [comparison of fixation dio-sensitest and disk diffusion techniques for the antibiotic sensitivity of some enteric bacteria]. | 2002 | 12476776 | |
| epidemiology of bloodstream infection in nursing home residents: evaluation in a large cohort from multiple homes. | this study sought to reevaluate the epidemiology of bloodstream infection in nursing home residents. the records of 166 nursing home residents admitted to an urban, public, university-affiliated hospital with 169 episodes of bloodstream infection between january 1997 and april 2000 were retrospectively reviewed. the most common organisms isolated were escherichia coli (27% of isolates), staphylococcus aureus (18%; 29% were methicillin-resistant strains), and proteus mirabilis (13%). there was mi ... | 2002 | 12471567 |
| germline mutation of the tumour suppressor pten in proteus syndrome. | 2002 | 12471211 | |
| effect of arginine-vasopressin on amoeba proteus: specific features of signal transmission. | 2002 | 12469403 | |
| first occurrence of transferable extended-spectrum beta-lactamase hydrolyzing cefoperazone in multiresistant nosocomial strains of klebsiella pneumoniae from two hospitals in czech and slovak republics. | the occurrence of positive synergy between antibiotic discs of amoxicillin/clavulanate and cefoperazone was registered in two klebsiella pneumoniae strains, isolated from hospitals in czech and slovak republic, indicating the presence of genes coding for an extended-spectrum beta-lactamase active also against cefoperazone, a broad-spectrum cephalosporin. sulbactam inhibited the hydrolysis of cefoperazone by cell-free lysates of these strains which substantiates its use in combination with cefope ... | 2002 | 12462425 |
| tryptophan indole-lyase from proteus vulgaris: kinetic and spectral properties. | an efficient method for purification of recombinant tryptophanase from proteus vulgaris was developed. catalytic properties of the enzyme in reactions with l-tryptophan and some other substrates as well as competitive inhibition by various amino acids in the reaction with s-o-nitrophenyl-l-cysteine were studied. absorption and circular dichroism spectra of holotryptophanase and its complexes with characteristic inhibitors modeling the structure of the principal reaction intermediates were examin ... | 2002 | 12460117 |
| mandibular osteomyelitis in a squirrel monkey. | although nonhuman primates often have their canine teeth cut or removed for safe handling, osteomyelitis of the mandible or maxilla has rarely been reported in laboratory animal literature. in the case reported here, a young adult squirrel monkey had a draining skin lesion on the left mandible. the monkey was treated with trimethoprim/sulfamethoxazole. the lesion resolved, but recurred. culture of a specimen from the deep portion of the lesion yielded staphylococcus aureus and a proteus sp. radi ... | 1997 | 12456196 |
| structural and serological characterization of the lipopolysaccharide from proteus penneri 20 and classification of the cross-reacting proteus penneri strains 10, 16, 18, 20, 32 and 45 in proteus serogroup o17. | o-specific polysaccharide (o-antigen) of the lipopolysaccharide of proteus penneri 20 was studied using sugar analysis along with various one- and two-dimensional nmr spectroscopy techniques. the following structure of the polysaccharide was established: [formula: see text] it has the same carbohydrate backbone structure as that described earlier for p. penneri 16, in which the positions of the o-acetyl groups have not been determined. p. penneri 20 o-antiserum showed a strong cross-reactivity w ... | 2002 | 12455869 |
| the helicobacter pylori flba flagellar biosynthesis and regulatory gene is required for motility and virulence and modulates urease of h. pylori and proteus mirabilis. | helicobacter pylori and proteus mirabilis ureases are nickel-requiring metallo-enzymes that hydrolyse urea to nh3 and co2. in both h. pylori and in an escherichia coli model of h. pylori urease activity, a high affinity nickel transporter, nixa, is required for optimal urease activity, whereas the urea-dependent urer positive transcriptional activator governs optimal urease expression in p. mirabilis. the h. pylori flba gene is a flagellar biosynthesis and regulatory gene that modulates urease a ... | 2002 | 12448680 |
| brain abscess complicating cerebral infarct. | we report a case of a 68-year-old man who suffered ischemic strokes in the left middle cerebral artery territory and three months later, following urosepsis, developed a cerebral abscess in the infarcted area. | 2002 | 12446296 |
| brain abscess caused by aerobic gram-negative bacilli: clinical features and therapeutic outcomes. | thirty-three patients (24 males and nine females) with brain abscesses resulting from infection by aerobic gram-negative bacilli were identified at kaohsiung chang gung memorial hospital over a period of 14 years. of these, 23 cases developed spontaneously, with the remaining ten postneurosurgery. the organisms most frequently involved were klebsiella (k.) pneumoniae, pseudomonas aeruginosa, escherichia coli and proteus species and included some rare pathogens, such as salmonella and enterobacte ... | 2002 | 12445926 |
| isolation of lacz fusions to proteus mirabilis genes regulated by intercellular signaling: potential role for the sugar phosphotransferase (pts) system in regulation. | using a mini-tn5lacz1 reporter transposon, lacz fusions have been identified in proteus mirabilis that are activated by the accumulation of self-produced extracellular signals. genes identified by this approach include putative homologs of pgm, nlpa and two genes of unknown function. the extracellular signal(s) involved in activation were resistant to the effects of acid and alkali. the signal required for activation of (nlpa) cma482::lacz was sensitive to protease, suggesting the signal is a pe ... | 2002 | 12445644 |
| a muscular lesion suggestive of focal myositis in a child with proteus syndrome. | proteus syndrome is a polymorphic hamartomatous disorder associated with a broad spectrum of rare congenital malformations. many neoplasms have been linked to this condition, including lipomas, lymphangiomas, and hemangiomas. the authors describe a case of a congenital muscular lesion in a child with proteus syndrome. this mass was painless but was growing out of proportion to her leg musculature. a magnetic resonance imaging scan and incisional biopsy showed findings consistent with focal myosi ... | 2002 | 12439276 |
| pathological and therapeutic significance of cellular invasion by proteus mirabilis in an enterocystoplasty infection stone model. | proteus mirabilis infection often leads to stone formation. we evaluated how bacterium-mucin adhesion, invasion, and intracellular crystal formation are related to antibiotic sensitivity and may cause frequent stone formation in enterocystoplasties. five intestinal (caco-2, ht29, ht29-18n2, ht29-fu, and ht29-mtx) and one ureter cell line (sv-huc-1) were incubated in artificial urine with five proteus mirabilis strains. fluorescence-activated cell sorting (facs), laser scanning microscopy, and el ... | 2002 | 12438382 |
| biochemical characterization of tem-92 extended-spectrum beta-lactamase, a protein differing from tem-52 in the signal peptide. | a bla(tem-92) gene was cloned from a proteus mirabilis isolate and expressed in escherichia coli. production of the enzyme caused reduction of susceptibility to penicillins and narrow- to expanded-spectrum cephalosporins but not to moxalactam and cephamycins. determination of kinetic parameters with the purified enzyme revealed hydrolysis of expanded-spectrum cephalosporins, while cephamycins, moxalactam, and aztreonam were very poorly or not hydrolyzed. clavulanate and penicillanic acid sulfone ... | 2002 | 12435705 |
| distribution of extended-spectrum beta-lactamases in clinical isolates of enterobacteriaceae in vietnam. | among 730 escherichia coli, 438 klebsiella pneumoniae, and 141 proteus mirabilis isolates obtained between september 2000 and september 2001 in seven hospitals in ho chi minh city, vietnam, 26.6% were resistant to ceftazidime, 30% were resistant to cefotaxime, 31.5% were resistant to ceftriaxone, 15.9% were resistant to cefoperazone, and 6% were resistant to cefepime. resistance to imipenem was found in 5.6% of the isolates. in 55 strains producing extended-spectrum beta-lactamases (32 e. coli i ... | 2002 | 12435670 |
| lower genital tract infections in diabetic women. | the influence of glucose metabolism is seen in many infectious diseases, making diabetic patients more vulnerable to sepsis and other serious sequelae of bacterial invasion. vaginal candidiasis is a common problem if the glycemia is poorly controlled. the level of glucose concentration in the blood after ingestion of sugar seems to explain an increased likelihood of recurrent infection. specific immune aberrations, such as an elevated t-helper 2 response and a blunted t-helper 1 response, leadin ... | 2002 | 12433331 |
| effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. | resveratrol (3, 4', 5-trihydroxystilbene), a natural polyphenol, is found in some plants that are used in human nutrition. grapes are a major source for resveratrol, and a significant amount can also be found in red wine. several experimental studies have demonstrated biological properties of resveratrol, especially its anti-inflammatory, antioxidant, anti-platelet and antitumor effects. in the present study, we investigated the first step of platelet activation-platelet adhesion stimulated by l ... | 2002 | 12431480 |
| the inner-core lipopolysaccharide biosynthetic waae gene: function and genetic distribution among some enterobacteriaceae. | to determine the function of the waae gene in the biosynthesis of the inner-core lps of klebsiella pneumoniae, a waae non-polar mutant has been constructed. data obtained from the comparative chemical analysis of lps samples obtained from the wild-type, the mutant strain and the complemented mutant demonstrated that the waae gene is involved in substitution of alpha-l-glycero-d-manno-heptopyranose i (l,d-heppi) at the o-4 position by a beta-d-glucopyranose (beta-d-glcp) residue. in addition, dna ... | 2002 | 12427940 |
| indigoferabietone, a novel abietane diterpenoid from indigofera longeracemosa with potential antituberculous and antibacterial activity. | from the stems of indigofera longeracemosa, a novel abietane diterpenoid, indigoferabietone was isolated. the structure was established by spectral techniques. the inhibitory activity of indigoferabietone (1) tested against mycobacterium tuberculosis and candida albicans, and the antibacterial activity tested against staphylococcus aureus, proteus vulgaris, and escherichia coli were found to be significant. | 2002 | 12426956 |
| antimicrobial properties and phytochemical constituents of the leaves of african mistletoe (tapinanthus dodoneifolius (dc) danser) (loranthaceae): an ethnomedicinal plant of hausaland, northern nigeria. | african mistletoe (tapinanthus dodoneifolius (dc) danser) called 'kauchi' in hausa is a hemi-plant parasite used ethnomedicinally by the hausa and the fulani tribes of northern nigeria as a remedy for several human and animal ailments that include stomach ache, diarrhoea, dysentery, wound and cancer. screening of the plant, obtained from 14 different hosts, revealed a wide spectrum of antimicrobial activities against certain multiple drug resistant bacterial and fungal isolates of farm animals. ... | 2002 | 12426091 |
| [fibrin-collagen substance as a vehicle for local application of antibacterial agents]. | inhibitory activity of fibrin-collagen substance (fcs) impregnated by various antibacterial agents against various microorganisms was investigated. it was demonstrated that antibacterials bind well with fcs, providing its sufficient antibacterial activity. determination of growth-inhibition zones showed that antibacterial agents diffuse into medium well and demonstrated the same activity as discs with antibiotics. for clinical practice it is recommended to use for impregnation the following drug ... | 2002 | 12422648 |
| modification of dienes mutual inhibition test for epidemiological characterization of pseudomonas aeruginosa isolates. | pseudomonas aeruginosa is an important cause of community-associated and nosocomial infections related to exposure to aqueous environments. such infections often occur in the setting of a common-source outbreak, in which case epidemiological characterization of isolates may be necessary. in this preliminary study, a modification of the dienes mutual inhibition test, ordinarily used to assess the relatedness of swarming proteus mirabilis strains, was used to study 15 p. aeruginosa isolates, with ... | 2002 | 12409411 |
| characterization of cmy-type beta-lactamases in clinical strains of proteus mirabilis and klebsiella pneumoniae isolated in four hospitals in the paris area. | we isolated five clinical strains (three proteus mirabilis and two klebsiella pneumoniae) with beta-lactam resistance phenotypes consistent with production of an ampc-type beta-lactamase. the predicted amino acid sequences of the enzymes were typical of class c beta-lactamases. the enzymes were identified as cmy-2, cmy-4 and a new cmy-variant beta-lactamase, cmy-12. the ampc beta-lactamases from the two k. pneumoniae isolates were found to be encoded on self-transferable plasmids. the genes enco ... | 2002 | 12407124 |
| anti-salmonella activity of alkyl gallates. | a series of alkyl gallates (3,4,5-trihydroxybenzoates) was synthesized and tested for their antibacterial activity against salmonella choleraesuis. nonyl (c(9)) and octyl (c(8)) gallates were noted to be the most effective against this food-borne bacterium, each with a minimum bactericidal concentration (mbc) of 12.5 microg/ml, followed by decyl (c(10)) gallate, with a mbc of 25 microg/ml. dodecyl (c(12)) gallate exhibited activity against s. choleraesuis, with a mbc of 50 microg/ml. propyl (c(3 ... | 2002 | 12405763 |
| antimicrobial activity of dequalinium chloride against leading germs of vaginal infections. | dequalinium chloride (cas 522-51-0) and povidone iodine (cas 25655-41-8) are known as antiseptic agents and used in the local treatment of vaginal infections. clotrimazole (cas 23593-75-1) is an anti-fungal drug and applied primarily in the therapy of vulvo-vaginal candidiasis and to a lesser extent in bacterial vaginosis and trichomoniasis. however, antimicrobial activities of those three agents in comparison to each other have not been reported so far. to address this issue the antimicrobial a ... | 2002 | 12404886 |
| enzyme fingerprints by fluorogenic and chromogenic substrate arrays we would like to thank prof. r. furstoss and dr. a. archelas at the faculté des sciences de luminy, marseille, france, for providing a sample of aspergillus niger eh, and dr. c. weijers at the department of food technology and nutrition sciences, wageningen university, the netherlands, for providing a sample of rhodotorula glutinis eh. this work was supported by the university of bern, the european cost program (action d12), the swiss office fédéral de l'education et de la science, protéus sa (nîmes, france), the ministero della università e della ricerca scientifica e tecnologica (murst), and consiglio nazionale delle ricerche (cnr) (roma). p.c. gratefully acknowledges merck for generous financial support from a 2000 adp chemistry award. | 2001 | 12404444 | |
| [triclosan, a topical dermatologic agent. in vitro- and in vivo studies on the effectiveness of a new preparation in the new german formulary]. | triclosan (2,4,4'-trichloro-2'-hydroxydiphenyl ether) is an antiseptic suitable for formulation as a w/o emulsion. the objective of the present study was to explore its potential utility in atopic dermatitis and prophylactic skin care following leg eczema and leg ulcer treatment. | 2002 | 12402134 |
| serum levels of prophylactic cefazolin during cardiopulmonary bypass surgery. | controversy exists regarding the appropriate prophylactic dose of cefazolin for coronary artery bypass grafting (cabg) surgery requiring cardiopulmonary bypass (cpb) because the effect of cpb on serum drug levels is poorly understood. current standards of prophylaxis are based primarily on empiric studies. few studies have attempted to quantify serum cefazolin levels in either cardiac or noncardiac surgeries. this study was conducted to measure and assess the adequacy of the intraoperative serum ... | 2002 | 12400766 |
| infestation of fish-culturing communities with fish-borne bacteria: the ghanaian case. | twenty different bacterial species were isolated from fishermen and members of communities associated with seven fish ponds with different fertilizer treatments, and an open system. the number and types of the bacterial species were different for the different ponds. generally, neither the geographical location of the ponds nor the type of fertilizer used could be related to the bacterial flora. escherichia coli was the predominant species in all the communities, while escherichia coli, klebsiel ... | 2002 | 12400540 |
| characterisation of local isolates of enterobacteriaceae from turkey. | 20 local isolates of enterics belonging to the genera salmonella, enterobacter, proteus, citrobacter from human, chicken and/or egg were characterised for their antibiotic resistance patterns, plasmid profiles, phage types, outer membrane proteins, and lipopolysaccharide patterns. relatedness of these characteristics for epidemiological analysis was assessed. 18 (90%) strains were resistant to at least one antibiotic and those (multi-drug resistant ones) resisting to two or more antibiotics cons ... | 2002 | 12398294 |
| [psoas abscess. etiology and treatment]. | psoas abscess is in general a syndrome with low incidence. in the following, two cases are presented which describe the etiology, diagnosis, and treatment of primary and secondary retroperitoneal manifestations. the article mainly focuses on the different respective surgical procedures. because of its rareness, an overview of further cases discussed in the literature is provided. | 2002 | 12395166 |
| comparison of three chromogenic agar plates for isolation and identification of urinary tract pathogens. | to comparatively assess the performance of three chromogenic agar plates, cps id2, chromogenic uti, and usa, for the detection and enumeration of all urinary tract pathogens and the direct identification of escherichia coli, proteus mirabilis and enterococcus spp. | 2002 | 12390282 |
| is there a need for postoperative surveillance after day case groin surgery in children? | there is increasing awareness of the value of day case paediatric surgery in fulfilling the needs of the community. is this cost effective, are there hidden complications and is there a need for routine follow-up? seven hundred and thirty-one children attending the red cross war memorial children's hospital day surgery unit over a 32-month period, and undergoing 912 procedures confined to the inguinoscrotal region, were enrolled in the study. surgical procedures performed included inguinal herni ... | 2002 | 12387217 |
| identification of a chromosome-borne expanded-spectrum class a beta-lactamase from erwinia persicina. | from whole-cell dna of an enterobacterial erwinia persicina reference strain that displayed a penicillinase-related antibiotic-resistant phenotype, a beta-lactamase gene was cloned and expressed in escherichia coli. it encoded a clavulanic-acid-inhibited ambler class a beta-lactamase, erp-1, with a pi value of 8.1 and a relative molecular mass of ca. 28 kda. erp-1 shared 45 to 50% amino acid identity with the most closely related enzymes, the chromosomally encoded enzymes from citrobacter koseri ... | 2002 | 12384342 |
| multiple antimicrobial resistance in gram negative bacilli isolated from clinical specimens, jimma hospital, southwest ethiopia. | a total of 413 clinical specimens (pus, blood, urine, and stool) collected from patients admitted to jimma hospital were cultured for isolation and identification of aerobic bacteria and antimicrobial susceptibility testing. out of these, 124 specimens yielded one or more gram-negative bacilli strains. frequent gram negative bacterial isolates were proteus species 34(27%), klebsiella species 26(21%), enterobacter species 24(19%), and e. coli 24(19%). antimicrobial susceptibility test results sho ... | 2001 | 12380230 |
| infectious background of patients with a history of acute anterior uveitis. | to study the infectious background of patients with a history of acute anterior uveitis (aau) and healthy control subjects. | 2002 | 12379526 |
| [in vitro and in vivo antibacterial activities of pazufloxacin mesilate, a new injectable quinolone]. | we investigated the in vitro and in vivo antibacterial activities of pazufloxacin mesilate (pzfx mesilate), a new injectable quinolone, and obtained the following results. 1) the mic50 and mic90 values of pzfx against clinically isolated gram-positive and -negative bacteria, ranged from 0.0125 to 12.5 micrograms/ml and 0.025 to 100 micrograms/ml, respectively. pzfx showed broad spectrum activity. the antibacterial activities of pzfx against quinolone-susceptible, methicillin-resistant staphyloco ... | 2002 | 12378871 |