| [clinical laboratory approach for estimating the effective administrative dose of latamoxef. significance of a 4-category system interpretation of the latamoxef disc susceptibility test]. | in vitro activities of latamoxef (lmox) against 249 clinical isolates were determined using the agar dilution method at an inoculum level of 10(6) cfu/ml. lmox was highly active against escherichia coli, klebsiella pneumoniae, proteus mirabilis (except 2 out of 30 strains) and proteus vulgaris with mic values below 3.13 micrograms/ml. it was also active against enterobacter aerogenes with mic80 of 1.56 micrograms/ml. lmox was less active against serratia marcescens, inhibiting about 43% of strai ... | 1987 | 3327966 |
| [cerebral abscess caused by proteus mirabilis in the neonatal period]. | eight cases of cerebral abscesses due to proteus mirabilis in the newborn period are reported. the authors emphasize the insidiousness of the clinical features, and the use of ultrasound screening for an early recognition, essential for the therapeutic results. | 1987 | 3328572 |
| investigation of a providencia rettgeri strain that has enterobacterial common antigen in the immunogenic state. | antigenic material obtained by phenol-water extraction from providencia rettgeri strains, escherichia coli o:14 strains, and mutants of the e. coli o:14 strain were examined by the passive (indirect) hemagglutination technique, by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and by immune blotting (lipopolysaccharide (lps) blotting). providencia rettgeri 965, like e. coli o:14, was demonstrated to have an enterobacterial common antigen (eca) in the immunogenic form but, unlike e. c ... | 1987 | 3328641 |
| [susceptibility of gram-negative bacilli to aminoglycosides]. | in this study, the antibiotic sensitivity results of some gram-negative bacilli to aminoglycosides have been presented. 704 e. coli, 152 klebsiella, 158 proteus, 155 pseudomonas strains were examined. these bacilli were isolated from the clinical samples at the bacteriology lab.in ibni sina hospital, between january 1986-january 1987. the percents of e. coli strains susceptible to gentamicin, tobramycin, netilmicin and amikacin were 74%, 84%, 90%, 85% respectively. the sensitivity pattern of pro ... | 1987 | 3328818 |
| cloning and expression in escherichia coli of proteus vulgaris genes for 16s ribosomal rna. | in contrast to the established systems of plasmid-coded homologous ribosomal dna (rdna) cistrons in escherichia coli little is known about the fate of heterologous rrna. in order to study expression of foreign rdna, rrna cistrons from proteus vulgaris were cloned in phage vector charon 35, subcloned in pbr322 and transformed in e. coli. the inserts of two clones (ppm2 and ppm14) were characterized by restriction analysis and southern hybridization. each of them harboured a complete rrn cistron. ... | 1987 | 3329212 |
| [analysis of bacterial cultures from 40 cases of periodontal abscess and their drug sensitivity]. | | 1987 | 3330006 |
| [experimental cystitis in the rat and the therapeutic effect of a single dose of fosfomycin trometamol]. | | 1987 | 3330644 |
| imipenem/cilastatin for pediatric infections in hospitalized patients. | one hundred and four children who were hospitalized for documented or suspected non-cns bacterial infections (56 males/48 females, 22 days to 15 years old) were treated with intravenous imipenem/cilastatin for 9.4 days (range 3 to 28 days). children up to three years of age received 100 mg/kg/day and older children 60 mg/kg/day, administered in four divided doses. bacterial pathogens were isolated before therapy in 85%. diagnoses in the 74 evaluable patients included bronchopneumonia with or wit ... | 1987 | 3331043 |
| nonsurgical management of neonatal multiple brain abscesses due to proteus mirabilis. | a newborn infant with proteus mirabilis meningitis developed multiple brain abscesses with diameters ranging from 2 to 4 cm. intravenous antibiotic therapy alone without surgical intervention led to the complete resolution of this complication. the case supports that this may be an acceptable treatment of multiple brain abscesses in neonates. however, the clinical outcome was relatively poor, since a porencephalic cyst, hypodense areas in ct scan, and psychomotor retardation were found at one ye ... | 1987 | 3331388 |
| [the role of ofloxacin (tarivid) therapy in respiratory and urinary tract infections]. | in this study, 14 patients with urinary tract infection and 8 patients with respiratory tract infection were given 400 mg/day of ofloxacin. 12 of 14 patients with urinary tract infection and 4 of 8 patients with respiratory tract infection was cured and clinically improved. 12 of 13 e. coli isolates were eradicated with this treatment. no severe adverse reactions were observed. no in vitro resistance against ofloxacin was seen. | 1987 | 3332699 |
| [susceptibility of some bacteria isolated from clinical samples to third-generation cephalosporins]. | in this study, we evaluated the susceptibility of some staph. aureus, staph. epidermidis, e. coli, klebsiella, proteus, pseudomonas strains to third-generation cephalosporins in-vitro by disk diffusion technique which are in use in turkey. these bacteria isolated from various clinical samples at the bacteriology laboratory in ibni sina hospital between january 1986-january 1987. the antibiotics used in this study are ceftizoxime, cefotaxime, ceftriaxone, cefoperazone. according to the results of ... | 1987 | 3332704 |
| treatment of intra-abdominal abscess in a patient with complicated crohn's disease. | | 1987 | 3334602 |
| re: considerations in the choice of sutures for wound closure of the genitourinary tract. | | 1988 | 3336087 |
| septicemia from biliary tract infection. | one hundred four strains of microorganisms were isolated from the blood in 76 episodes of septicemia originating from biliary tract infection. the 70 patients involved included 40 with acute cholecystitis without previous surgery, 17 with cholangitis following previous surgery, and 13 patients with malignant disease, with or without previous surgery. the most common organisms were escherichia coli, klebsiella, streptococcus, and proteus. various streptococci, most of them from group d, were invo ... | 1988 | 3341915 |
| numerical analysis of electrophoretic protein patterns of providencia alcalifaciens strains from human faeces and veterinary specimens. | twenty-five strains of providencia alcalifaciens from various countries have been characterized by one-dimensional sds-page of cellular proteins. they comprised 15 from human faeces, one from duck faeces, one from a guinea-pig eye and eight from unknown sources. also included, for reference purposes, were the type strains of three other providencia species. the protein patterns, which contained 45-50 discrete bands, were highly reproducible and were used as the basis for two numerical analyses. ... | 1988 | 3350783 |
| interactions between antibacterial agents of the quinolone group and nitrofurantoin. | plate diffusion tests showed that nitrofurantoin antagonized the activity of nalidixic acid, norfloxacin, ciprofloxacin and enoxacin against many gram-negative bacilli, including all proteus mirabilis and klebsiella aerogenes strains tested. no interaction was exhibited when nitrofurantoin and the newer quinolones were tested against pseudomonas aeruginosa, staphylococci or streptococci. antagonism was not reliably demonstrated in chessboard titrations, especially with the newer quinolones. cont ... | 1988 | 3356622 |
| microbial keratitis associated with contaminated ocular medications. | we studied seven cases of severe gram-negative microbial keratitis associated with the use of contaminated topical ocular medications. five cases involved pseudomonas aeruginosa, one involved serratia marcescens, and one involved proteus mirabilis. in each case the same organism was cultured from corneal scrapings and from the medication. either prednisolone acetate (one case) or timolol maleate (seven cases) was implicated in all instances. | 1988 | 3358428 |
| a survey of clinical experience with ciprofloxacin, a new quinolone antimicrobial. | ciprofloxacin is a new quinolone antimicrobial agent with activity against a broad spectrum of gram-negative and gram-positive organisms, including pseudomonas aeruginosa and methicillin-resistant strains of staphylococci. the efficacy and safety results of 80 clinical studies of the oral form of ciprofloxacin are reported. drug safety was assessed in 2236 courses in 2203 adult patients treated primarily in the united states. data from 1676 courses were suitable for analysis of drug efficacy. th ... | 1988 | 3360968 |
| [interrelations between klebsiella ozaenae and other members of a microbial association in a pathological ozenous focus]. | the study of relationships between individual representatives of the microeubiosis at a pathological ozenous focus has shown that gram-positive microorganisms and opportunistic enterobacteria are not antagonistic to k. ozaenae which, in their turn, do not affect the growth of opportunistic enterobacteria and pseudomonas aeruginosa. the overwhelming majority of p. aeruginosa strains (92.9%) grown on a solid culture medium are characterized by a varying antagonistic activity with respect to k. oza ... | 1988 | 3364076 |
| cell-mediated immunity assessed by skin testing (multitest). ii: correlation between responses from arm and back. | in 60 healthy adult volunteers and 58 patients with gastrointestinal disease a test system (multitest) consisting of a plastic disposable multiple-puncture device capable of simultaneously applying seven delayed-type hypersensitivity antigens and a glycerin/saline diluent (negative control) was assessed. the multitest device was applied on both the inner side of the forearm and on the back for assessment of cell-mediated immunity (cmi). the antigens used were two toxoids, tetanus and diphtheria, ... | 1988 | 3364623 |
| new plate medium for screening and presumptive identification of gram-negative urinary tract pathogens. | a new selective, differential plating medium to screen the common gram-negative urinary tract pathogens is described. the medium combines adonitol fermentation, phenylalanine deaminase, and beta-glucuronidase tests and allows the indole and cytochrome oxidase tests to be performed directly from the plates. high-level agreement with individual conventional tests was recorded in comparative studies with 504 cultures of gram-negative rods. there was 100% agreement, except for the providencia spp. i ... | 1988 | 3366875 |
| kell blood group activity of gram-negative bacteria. | to understand better the relationships between blood-group antigens and bacterial constituents, examples of 23 gram-negative bacteria (representing the 10 genera citrobacter, edwardsiella, enterobacter, escherichia, klebsiella, proteus, pseudomonas, salmonella, serratia, and shigella) were tested for the presence of kl-like antigens by hemagglutination-inhibition (hai) assays against both igg and igm anti-kl. saline-suspended whole organisms, cell-free culture media, and disrupted organisms were ... | 1988 | 3368935 |
| [effectiveness of prodigiozan, methyluracil and levamisole in experimental infection after administration of non-steroidal anti-inflammatory drugs]. | the effect of nonsteroid antiinflammatory drugs (naid) such as voltaren, acetylsalicylic acid, indometacin and naproxen on the efficacy of immunostimulators in treatment of infections caused by proteus and staphylococcus was studied. it was shown that except naproxen the naid were capable of decreasing resistance to proteus infections. acetylsalicylic acid increased resistance to staphylococcal infections. the rest of the drugs did not change it. prodigiozan increased resistance to the infection ... | 1988 | 3377603 |
| a computer-assisted structural analysis of regular polysaccharides on the basis of 13c-n.m.r. data. | a computerised approach to the structural analysis of unbranched regular polysaccharides is described, which is based on an evaluation of the 13c-n.m.r. spectra for all possible primary structures within the additive scheme starting from the chemical shifts of the 13c resonances of the constituent monosaccharides and the average values of the glycosylation effects. the analysis reveals a structure (or structures), the evaluated spectrum of which resembles most closely that observed. the approach ... | 1988 | 3378242 |
| [skin reactions with ubiquitous multiple antigens as a test of survival in patients with inoperable bronchogenic carcinoma]. | fifty-three patients suffering from inoperable, non-microcytoma, bronchogenic carcinoma in which a skin reaction with ubiquitous antigens (tetanus, diphtheria, streptococcus, tuberculin, proteus, tricophyton, candida) had been carried out were followed up to check on the possible relationship between skin reactivity and survival period. a significant correlation was found between the degree of positivity and duration of survival, with mean survival values greater than 69.1 weeks being observed i ... | 1988 | 3380311 |
| cutaneous manifestations of the proteus syndrome. | the proteus syndrome is a rare disorder in which the major manifestations are skeletal overgrowth, digital hypertrophy, exostoses of the skull, and hamartomatous tumors. numerous skin lesions also occur. we treated six individuals, all of whom had the features unique to this syndrome of marked hypertrophy of the skin of the soles. the palms were similarly involved in two patients. light microscopy of biopsy material from thickened areas of the soles showed elongation of the cytoplasm of the basa ... | 1988 | 3380758 |
| a survey of the aerobic bacteria in the feces of captive raptors. | feces of 47 captive raptors belonging to the order falconiformes or strigiformes were cultured for bacteria. gram-negative bacteria, which were cultured from the feces of 45 of the 47 raptors, were the most common isolates. a wide variety of species were identified, including a newly described genus (moellerella wisconsensis), two newly described species (escherichia fergusonii and proteus penneri), and a member of a newly described enteric group (cdc enteric group 41). additional organisms iden ... | 1988 | 3382380 |
| characterization of urease from campylobacter pylori. | campylobacter pylori, a suspected agent of gastritis and peptic ulceration, rapidly hydrolyzes urea. because urease serves as the basis of detection of the organism in gastric biopsies and may represent an important virulence factor, biochemical characteristics of the enzyme were determined. c. pylori was isolated from antral biopsies from 10 patients with complaints of abdominal pain or history of peptic ulcer disease. all isolates were urease positive, with an average rate of hydrolysis by cel ... | 1988 | 3384908 |
| the phylogenetic origin of the bifunctional tyrosine-pathway protein in the enteric lineage of bacteria. | because bifunctional enzymes are distinctive and highly conserved products of relatively infrequent gene-fusion events, they are particularly useful markers to identify clusters of organisms at different hierarchical levels of a phylogenetic tree. within the subdivision of gram-negative bacteria known as superfamily b, there are two distinctive types of tyrosine-pathway dehydrogenases: (1) a broad-specificity dehydrogenase (recently termed cyclohexadienyl dehydrogenase [cdh]) that can utilize ei ... | 1988 | 3386529 |
| ciprofloxacin: in vitro, experimental, and clinical evaluation. | ciprofloxacin at a concentration of 2 micrograms/ml inhibited the growth of approximately 90% of 584 strains of aerobic bacteria isolated from cultures of blood drawn from septicemic patients. an increase in the inoculum size did not result in an increased mic, but serial passages through media containing ciprofloxacin at sub-mic levels increased the mic for escherichia coli, klebsiella pneumoniae, and proteus vulgaris. in experimental subcutaneous abscesses in the mouse model, ciprofloxacin was ... | 1988 | 3393781 |
| recurrent and residual renal calculi in children. | one hundred and thirteen children with non-metabolic urinary tract calculi were operated on between 1960 and 1983. one hundred were followed up for 3 to 17 years (mean 8.2). seventeen children (15%) developed recurrent calculi after complete clearance at the initial operation and in 13 of these the stones recurred within 5 years. proteus urinary infection was a constant feature of stone recurrence. five patients required re-operation for removal of the recurrent calculus. small residual caliceal ... | 1988 | 3395797 |
| activity of cefotaxime and amikacin against 14,272 gram-negative bacteria from clinical samples in the period 1980 to 1985. | the sensitivity to cefotaxime and amikacin of 14,272 gram-negative bacilli (enterobacteriaceae and non-fermenting gram-negative bacilli) isolated from clinical samples was studied during the period 1980 to 1985. the minimum inhibitory concentration (mic) was determined by means of diffusion in agar. strains were considered resistant to cefotaxime and amikacin if the mic values were greater than 16 mg/l and greater than 8 mg/l, respectively. the mic90 reached the critical value for cefotaxime in ... | 1988 | 3396470 |
| cefotaxime combined with selective decontamination in long term intensive care unit patients. virtual absence of emergence of resistance. | emergence of bacterial resistance to antimicrobial agents was studied during a period of 30 months of continuous use of parenteral cefotaxime combined with oral non-absorbable polymyxin e and tobramycin (selective decontamination) in a surgical intensive care unit (icu). no increase in drug-resistance micro-organisms was found. colonisation of the oropharyngeal cavity or intestine or both by strains resistant to polymyxin e occurred in 8% of patients (invariably proteus and morganella species). ... | 1988 | 3396487 |
| possible regulation of cation-induced pinocytosis in amoeba proteus by phospholipase a. | we have studied the effects of exogenous phospholipids and compounds which are known to alter the activity of phospholipase a (pla) on ca2+-dependent, na+-induced pinocytosis in amoeba proteus. the pla-inhibitors mepacrine, p-bromophenacyl bromide (pbpb) and rosenthal's inhibitor depressed pinocytosis. normal pinocytotic intensity was restored by the addition of ca2+ or picomolar concentrations of lysolecithin. very low concentrations of lysophospholipids and different molecular species of lecit ... | 1988 | 3396589 |
| recurrent gram-negative bacteremia. | recurrent gram-negative bacteremia is defined as two or more episodes of bacteremia occurring in the same patient with an infection-free interval between each episode. our purpose was to identify patients with recurrent gram-negative bacteremia in order to define possible risk factors for its recurrence. patients and | 1988 | 3400692 |
| [treatment of staghorn calculi by percutaneous nephrolithotomy. apropos of 18 cases]. | this series involves 19 kidneys treated by the same operator. the predominance of women (14/18) and of proteus urinary infection (11) was identical to other published series. 13/19 calculi with complete staghorn calculi occupying the renal pelvis and the 3 calyceal groups. 7 patients had a past history of 15 lombotomies for staghorn calculus. pcln was carried out under fluoroscopic visualisation only, in 13 cases with one single channel, in 4 cases with two channels and in 3 cases with three cha ... | 1988 | 3411131 |
| effect of circumcision status on periurethral bacterial flora during the first year of life. | to determine whether bacterial colonization is a factor in the pathogenesis of urinary tract infection, we compared the periurethral bacterial flora of uncircumcised versus circumcised boys during the first year of life. intraurethral and circumferential glans cultures were obtained from 25 circumcised and 25 uncircumcised infants at 2 days, 2 weeks, 2 months, 4 months, 6 months, and 12 months of age. different children were used at each age (300 total). the types of bacteria and the total and s ... | 1988 | 3411387 |
| ciprofloxacin activity in cyst fluid from polycystic kidneys. | renal cyst infection in patients with polycystic kidney disease (pkd) is often unresponsive to standard antimicrobial therapy, in part because of the failure of most antibiotics to adequately penetrate cyst fluid. ciprofloxacin, a new quinolone antibiotic, possesses in vitro activity against most pathogens likely to be encountered in renal cyst infection. to study the potential usefulness of ciprofloxacin for the treatment of cyst infection, fluid from 70 cysts was obtained from seven patients w ... | 1988 | 3415205 |
| [antiproteus activity of the serum of the blood of donors and of the agent "immunoglobulin"]. | | 1988 | 3420884 |
| cell-mediated immunity assessed by skin testing (multitest). i. normal values in healthy danish adults. | the multitest cmi system consists of a disposable multiple puncture device that simultaneously applies seven standardized recall antigens for assessment of cell-mediated immunity (cmi). the seven antigens included were toxoid from clostridium tetani and corynebacterium diphtheriae, tuberculin, plus antigens from streptococcus (group c), candida albicans, trichophyton mentagrophytes, and proteus mirabilis. a population of 352 healthy danish adults, aged between 17 and 90 years, was tested to dete ... | 1987 | 3425857 |
| preliminary studies on the effect of glutathione s-transferase from providencia stuartii on the antimicrobial activity of different antibiotics. | glutathione s-transferase has been isolated and purified from a providencia stuartii ch 114 strain. the effect of the enzyme on the antimicrobial activity of amikacin, cefotaxime, cephalexin, ampicillin, nalidixic acid, and ofloxacin was tested. the efficiency of all antibiotics tested, except nalidixic acid and ofloxacin, is relevantly decreased by the presence of glutathione s-transferase in the medium culture, as proved by the increased value of mic. the effect of glutathione s-transferase on ... | 1987 | 3427694 |
| urease activity of proteus penneri. | ten strains of proteus penneri isolated from geographically diverse laboratories were tested for urease activity. cell lysates from urea-induced cells had a mean activity of 4.9 +/- 4.1 mumol of nh3 per min per mg of protein. on nondenaturing 6% polyacrylamide activity gels, the enzymes of p. penneri had very similar electrophoretic mobilities within species and within the proteus genus but were distinct from the ureases of providencia and morganella species. on lower-percentage polyacrylamide, ... | 1987 | 3429622 |
| [primary management of fresh bite injuries of the face]. | the danger of dog bites is often exaggerated. the reason for this is a gram negative bacterium pasteurella multocida, which causes a serious infection within 12 h. among 143 dog bites we saw only two of these infections. the bacterial swabs from the mouths of 20 dogs revealed e. coli in 43%, streptococci in 33%, proteus in 30%, staph. epidermidis in 27% and enterococci in 25%. since the blood supply of the face is much more superior to that for instance of the legs, infections are rare and prima ... | 1987 | 3431292 |
| [treatment of urinary infection with cephadroxyl (pharmachem)--microbiological and clinical research]. | the bacteria isolated from the urine of renal patients were tested for sensitivity towards cephadroxyl (pharmachem) and other beta-lactam antibiotics--altogether 654 examinations were made. it was established that the gram-positive bacteria (excluding the enterococcus) are sensitive towards cephadroxyl. from the gram negative bacteria e. coli, klebsiella sp., enterobacter sp., p. mirabilis, citrobacter sp. showed the greatest sensitivity towards cephadroxyl, while the indole positive proteus wer ... | 1987 | 3433735 |
| comparative in vitro activities of 13 antimicrobial agents against morganella-proteus-providencia group bacteria from urinary tract infections. | we examined 741 urinary tract isolates of the morganella-proteus-providencia group, including the recently defined species proteus penneri, for susceptibilities to aminoglycosides, semisynthetic penicillins, and cephalosporins. the data emphasize the importance of identification to the species level on the basis of marked species differences in patterns of susceptibility. | 1987 | 3435110 |
| comparative antibacterial activities of temafloxacin hydrochloride (a-62254) and two reference fluoroquinolones. | the in vitro and in vivo properties of a new 1-difluorophenyl-6-fluoroquinolone, temafloxacin hydrochloride (a-62254), were compared with those of difloxacin and ciprofloxacin. temafloxacin hydrochloride was as active as ciprofloxacin and difloxacin against staphylococci and as active as ciprofloxacin and 2 twofold dilutions more active than difloxacin against streptococci. against gram-negative enteric bacteria and pseudomonas aeruginosa, temafloxacin hydrochloride was 2 twofold dilutions more ... | 1987 | 3435123 |
| numerical analysis of electrophoretic protein patterns of providencia rustigianii strains from human diarrhoea and other sources. | twenty strains of providencia rustigianii (including the type strain of prov. friedericiana) have been characterized by one-dimensional sds-page of cellular proteins. they comprised 12 strains (almost exclusively associated with the intestinal tract) from humans, plus eight largely from the intestinal tract of pig, penguin and environmental sources. the protein patterns, which contained 45-50 discrete bands, were highly reproducible and were used as the basis for two numerical analyses. in the f ... | 1987 | 3436856 |
| brain abscesses and ischemic necrotic lesions during early childhood. | the cases of seven children, all under 6 months of age, with cerebral abscesses are presented. in four cases, there was previous meningitis; the others presented with expanding mass lesions. the infectious agent was proteus in four cases and escherichia coli and citrobacter in one each; in another patient, no agent was isolated. in six children, there were multiple areas of ischemic necrosis. in one instance, these areas were in the hemisphere contralateral to the purulent collection. the peculi ... | 1987 | 3437963 |
| the bacteriology of nosocomial infections at tikur anbessa teaching hospital, addis ababa. | patients admitted to a teaching hospital in addis ababa were studied for nosocomial infection. of 2506 patients, 13% developed clinical infections, with the highest rate among obstetric/gynaecologic patients (17.0%). wound infection was the most frequent type of nosocomial infection (49%) followed by urinary tract infection (25%). antibiotic prophylaxis was given to 43% of the patients. gram-negative bacteria comprised 88% of all isolated strains enterobacteriaceae; 75% of all isolates were foun ... | 1987 | 3439462 |
| persistence of retinal dopamine cells in the degenerated eye of the cave salamander, proteus anguinus l. | the proteus anguinus l. is a blind cave perennibranch amphibian whose visual system undergoes an important morphogenetic degeneration in adulthood. the eyeball becomes atrophied and disappears under the fat tissue of the head. however, a retina can still be identified and a photophobic behavior of the animal indicates a remaining photosensitivity. in the oldest animal observed, some photoreceptor cells are still present as well as other types of retinal neurons. characteristic synapses are obser ... | 1987 | 3441352 |
| lipid a and related compounds. xiv. a new synthesis of lipid y, the reducing sugar moiety of salmonella- and proteus-type lipid a. | | 1987 | 3442881 |
| [antimicrobial activity of sulbactam/cefoperazone. comparison with other new cephems]. | antimicrobial activities of sulbactam/cefoperazone (sbt/cpz) against 50 fresh clinical isolates of staphylococcus aureus, escherichia coli, klebsiella pneumoniae, citrobacter freundii, enterobacter spp., serratia marcescens, proteus mirabilis, proteus vulgaris and pseudomonas aeruginosa were compared to those of cpz, cefotiam (ctm), cefotaxime (ctx) and latamoxef (lmox). minimal inhibitory concentrations (mic's) of sbt and cpz mixed in a ratio of 1:1 were determined by the dilution method using ... | 1987 | 3444015 |
| [studies on antibacterial activity of flomoxef and its distribution to serum and intraperitoneal exudate in surgery]. | 1. bacteria detected in cases of acute abdominal ailments encountered in the first department of surgery at hiroshima university and its related facilities during the recent 4 and a half years were reviewed and the antibacterial activities of flomoxef (fmox, 6315-s) against these isolates were investigated. as a result, this antibiotic was found to show very high activities against staphylococcus aureus, staphylococcus epidermidis, escherichia coli, klebsiella pneumoniae and proteus spp. 2. one ... | 1987 | 3444022 |
| bacteriophage treatment of suppurative skin infections. | the study material comprised 31 patients with chronic suppurative infections of the skin caused by pseudomonas, staphylococcus, klebsiella, proteus and escherichia. within 2-16 weeks of the treatment, an improvement of the general state was observed as well as suppression of the local inflammation, purification of a wound from the suppurative and necrotic content, faster healing of the ulcers and fully negative results of the bacteriologic tests. in 16 cases, an outstanding therapeutic effect wa ... | 1987 | 3447533 |
| a study of predominant aerobic microflora of black bears (ursus americanus) and grizzly bears (ursus arctos) in northwestern alberta. | swab specimens were obtained from nasal, rectal, and preputial or vaginal areas of 37 grizzly and 17 black bears, captured during may to june of 1981 to 1983, to determine the types and frequency of predominant aerobic microflora. bacterial genera most frequently isolated from bears were escherichia, citrobacter, hafnia, proteus, staphylococcus, and streptococcus species, comprising about 65% of the isolates. erwinia, xanthomonas, agrobacterium, rhizobium, and gluconobacter/acetobacter were also ... | 1987 | 3447691 |
| [comparative studies on activities of antimicrobial agents against causative organisms isolated from urinary tract infections (1985). iii. secular changes in susceptibility]. | sensitivities to antimicrobial agents of escherichia coli, klebsiella spp., citrobacter spp., enterobacter spp., proteus spp., pseudomonas aeruginosa and serratia marcescens isolated from infected patients were evaluated and compared according to the types of their infections, i.e., simple and complicated urinary tract infections with or without indwelling catheter. there were no apparent decreases in the sensitivity of e. coli isolated from patients with simple urinary tract infections. when da ... | 1987 | 3448256 |
| proteus: a suite of programs for prediction of structural features of proteins using an apple iie. | we have implemented several algorithms, developed by various authors for predicting structural features of proteins from their primary structure, on an apple iie and collected them in a suite, named proteus. this suite incorporates: (i) methods for predicting secondary structure; (ii) the algorithm for computing the hydropathy profile using one out of five available sets of parameters; (iii) the algorithms for calculating the hydrophobic moment plot; and (iv) for performing the amphipathic analy ... | 1987 | 3453242 |
| nurse-reported infections in a long term care facility. | 350 nurse-reported infectious episodes over a two year period were studied in a nursing home population. urinary tract infections were the most commonly reported, followed by respiratory and skin infections. of these cases cultured, the most common urinary organisms were proteus and e. coli; the most common respiratory pathogen was proteus; and the usual skin offender was staph aureus. cultures were obtained more commonly for urinary than for skin and respiratory infections. recurrent infections ... | 1986 | 3454530 |
| immunogenic effect of bacteriophage in patients subjected to phage therapy. | fifty seven cases of bacterial infections subjected to phage therapy were tested for a production of antibodies against the applied bacteriophages. monoinfections confirmed in 40 patients were caused in majority of cases by pyogenic staphylococci (29 cases) and rarely by gram-negative bacteria: klebsiella, escherichia, proteus and pseudomonas (11 cases). polyinfections caused by the above types of bacteria were recorded in 17 cases. the titer of neutralizing and hemagglutinating antibodies was d ... | 1987 | 3455646 |
| [cefotiam concentration in exudate from suction drain of patients with breast cancer following intravenous administration]. | cefotiam (ctm) in a dose of 2 g was given by intravenous bolus injection to 16 patients with breast cancer operated upon radical mastectomy with suction drainage. the materials of exudate from drain were taken at intervals by sterilized paper disc and determined by the paper disc method with proteus mirabilis atcc 21100 as the test organism to ctm concentrations. ctm concentrations in exudate from suction drain of patients increased quickly after intravenous injection, and reached to peak early ... | 1986 | 3457965 |
| imipenem coadministered with cilastatin compared with moxalactam: integration of serum pharmacokinetics and microbiologic activity following single-dose administration to normal volunteers. | we administered 1 g of imipenem along with equal amounts of cilastatin (a dehydropeptidase i inhibitor) or 2 g of moxalactam intravenously over a period of 30 min to six volunteers in a crossover manner 1 week apart. the antibiotic concentrations and pharmacokinetics for each drug were determined and integrated with the microbiologic activity by measuring the duration of time that the free drug concentrations remained above the mics for 90% of 581 clinical isolates and by measuring serum bacteri ... | 1986 | 3459390 |
| [bacterial and clinical studies on imipenem/cilastatin sodium in urological infection]. | antibacterial activities of imipenem (mk-0787), cefazolin (cez), cefmenoxime (cmx) and cefoperazone (cpz) were measured by using an agar dilution method against 243 strains of bacteria isolated from the patients with urinary tract infections. the mic80 of mk-0787 against s. epidermidis, e. faecalis, e. coli, k. pneumoniae, e. cloacae, s. marcescens, p. mirabilis, p. vulgaris and p. aeruginosa was less than or equal to 0.10, 3.13, less than or equal to 0.10, 0.20, 0.78, 1.56, 3.13, 3.13 and 6.25 ... | 1986 | 3463772 |
| [fundamental and clinical studies on imipenem/cilastatin sodium in pediatrics]. | fundamental and clinical studies were carried out on imipenem/cilastatin sodium (mk-0787/mk-0791) in pediatric patients. the following results were obtained. a total of 238 clinical isolates stocked by our department was employed to determine the minimum inhibitory concentrations (mics) of mk-0787 against various species of bacteria. the mk-0787 showed strong antibacterial activities against e. coli, salmonella, klebsiella, proteus, serratia, e. faecalis and s. epidermidis. somewhat weaker activ ... | 1986 | 3464779 |
| chronic suppurative otitis media in the solomon islands: a prospective, microbiological, audiometric and therapeutic survey. | chronic suppurative otitis media affected 3.8% of 3500 solomon island children under 15 years (and 6.1% under 5 years) and was the sole cause of conductive hearing loss recorded in 265 children tested audiometrically. it was characterised by early onset (65% under 18 months) male preponderance and large central tubotympanic perforations. measles, respiratory infections, swimming and malnutrition were identified as aetiological factors amenable to intervention. proteus and pseudomonas were the pr ... | 1986 | 3466089 |
| [antimicrobial activity of cefotiam against various clinical isolates from 1981 to 1985]. | some of new cephem antibiotics, particularly the so called the third generation cephalosporins, are reported to be potent inducers of beta-lactamases and to be responsible for developing microbial cross-resistance to multiple beta-lactam antibiotics and occasionally to the aminoglycosides (sanders and sanders, 1983). in japan, third generation cephalosporins such as cefotaxime, cefoperazone, ceftizoxime, and latamoxef became available in 1981, and cefmenoxime in 1982. therefore, it is of interes ... | 1986 | 3467078 |
| ofloxacin: therapeutic activity in experimental infections. | the therapeutic activity of ofloxacin, a new oral fluoroquinolone antibacterial agent, was tested in experimental infections in rodents. its activity was compared with that of nalidixic acid, norfloxacin, amoxicillin and cotrimoxazole in pseudomonas aeruginosa pyelonephritis in the rat, and with that of amikacin and cefotaxime in proteus morganii thigh infections in mice. ofloxacin proved to be more effective than reference drugs, even if parenterally administered, in reducing the bacterial coun ... | 1986 | 3467874 |
| antimicrobial activity of imipenem against 1386 clinical isolates. | 1386 isolates from clinical specimens were tested against imipenem by disc agar diffusion. the bacteria used in this study consisted of escherichia coli, enterobacter aerogenes, e. agglomerans, e. cloacae, klebsiella pneumoniae, k. oxytoca, k. ozanae, proteus mirabilis, p. vulgaris, providencia stuartii, p. rettgeri, acinetobacter calcoaceticus, citrobacter diversus, c. freundii, morganella morganii, serratia liquefaciens, s. marcescens, hafnia alvei, aeromonas hydrophila, pseudomonas aeruginosa ... | 1986 | 3468319 |
| comparative activity of ofloxacin and seven other antimicrobials against urea-splitting microorganisms. | urinary tract infections caused by urea-splitting bacteria are severe clinical conditions and very difficult to treat due to their association with calculi, and because such bacteria form ammonium hydroxide raising the urinary ph and thereby creating an unfavourable condition for the action of most antimicrobials. we tested ofloxacin, norfloxacin, nalidixic acid, amoxicillin, amoxicillin-clavulanic acid, gentamicin, co-trimoxazole and nitrofurantoin against 143 gram-negative and 99 gram-positive ... | 1986 | 3469152 |
| ofloxacin in oral chemotherapy of acute and chronic otitis media. | after ascertaining the bacterial spectrum in 210 patients with otitis media acuta, otitis media chronica mesotympanalis and otitis media chronica epitympanalis, the clinical efficacy of oral therapy with ofloxacin in 40 patients from each of these groups was assessed. the clinical results are comparable with those following conventional local, oral and intravenous antibiotic therapy. the microbiological analysis of the ear secretions revealed staphylococcus aureus, streptococcus pyogenes and hae ... | 1986 | 3469167 |
| imipenem as monotherapy in the treatment of intensive care patients with severe infections. | in an open study, 24 intensive care patients were treated with imipenem/cilastatin as monotherapy for serious bacterial infections. twenty-one patients were treated for bronchopulmonary infection, two patients for septicaemia, and one patient for an empyema. initially all strains were susceptible to imipenem. gram-negative bacilli accounted for 80% of these isolates. the most frequently isolated species were proteus mirabilis, escherichia coli and pseudomonas aeruginosa. all 24 patients were con ... | 1986 | 3469187 |
| experience with imipenem/cilastatin in the intensive care unit. | twenty-two patients admitted to the icu with a severe nosocomial infection caused by multi-resistant gram-negative bacilli were treated with imipenem combined with cilastatin. we treated nine cases of meningo-ventriculitis, eight cases of septicaemia, four cases of mediastinitis, and one case of pneumonia. the bacteria responsible were acinetobacter spp. (10), pseudomonas aeruginosa (5), enterobacter cloacae (5), klebsiella pneumoniae (3), proteus spp. (2), streptococcus spp. (2), serratia marce ... | 1986 | 3469188 |
| evaluation of imipenem/cilastatin against nosocomial infections and multiresistant pathogens. | thirty-five patients suffering from soft tissue infections (12), upper utis (6), bronchopneumonia (6), septicaemia (2), chronic osteomyelitis (2), intra-abdominal abscess (2), liver abscess (1), lung abscess (1), acute cholangitis (1), thoracic empyema (1) and chronic prostatitis (1) were given imipenem/cilastatin for 6-21 days. in 22 patients several aggravating factors coexisted, while infection in 16 patients was polymicrobial. the following pathogens were implicated: pseudomonas aeruginosa ( ... | 1986 | 3469191 |
| in-vitro antibacterial activity of imipenem compared with four other beta-lactam antibiotics (ceftazidime, cefotaxime, piperacillin and azlocillin) against 828 separate clinical isolates from a portuguese hospital. | an agar dilution technique was used to determine the mic50 and mic90 of imipenem in comparison with ceftazidime, cefotaxime, piperacillin and azlocillin. eight hundred and eighteen of the 828 (98.8%) unselected gram-positive cocci and gram-negative bacilli were inhibited by imipenem at a concentration of 8 mg/l or less. imipenem was shown to be superior to the other four beta-lactam antibiotics against acinetobacter calcoaceticus (40 strains), all the staphylococcus aureus (80 strains, 10 of the ... | 1986 | 3469195 |
| an in vitro study of the interaction between cefotaxime and desacetylcefotaxime. | the in vitro activities of cefotaxime (ctx), desacetylcefotaxime (des), cefuroxime (cxm) and ceftizoxime (ctz) were compared against 272 recent clinical isolates and the effect of ctx and des in combination was studied using agar dilution checkerboards. ctx and ctz had similar activity, inhibiting 90% of escherichia coli, proteus spp., klebsiella spp. and providence spp. at 0.0075 mg/l. ninety percent of enterobacter spp. and serratia spp. were inhibited by 1 mg/l of ctx and ctz. ninety percent ... | 1986 | 3471432 |
| [clinical laboratory approach for estimating effective administrative dose of ceftizoxime. observation from mic and ceftizoxime disc susceptibility test]. | in vitro activities of ceftizoxime (czx) against 328 clinical isolates were determined using the agar dilution method at an inoculum level of 10(6) cfu/ml. czx was highly active against escherichia coli, klebsiella pneumoniae, proteus mirabilis, and proteus vulgaris with mic values below 0.20 microgram/ml. it was also active against serratia marcescens and enterobacter aerogenes with mic85 of 3.13 micrograms/ml. czx was less active against staphylococcus aureus and staphylococcus epidermidis, sh ... | 1987 | 3474430 |
| [nationwide study of the antimicrobial susceptibility of clinical isolates of proteus group in japan]. | we discussed the antimicrobial susceptibilities of proteus group isolated in 1983 and 1984 and also the annual changes of the susceptibilities from 1980 to 1984. the tested strains were isolated in 103 hospitals in japan. antibiotics tested for this study were ampicillin (abpc), cefazolin (cez), cefmetazole (cmz), and gentamicin (gm). the mic's were determined by the standard method of the japan society of chemotherapy. susceptibilities of the bacterial strains to the 4 antibiotics were describe ... | 1987 | 3475483 |
| in vitro study of the antibacterial activity of ofloxacin against recent clinical isolates. | the in vitro activity of ofloxacin, a new broad-spectrum antimicrobial agent, was studied by a standardized single disc method. a total of 990 clinical isolates were tested, including 20 strains of anaerobic bacteria. ofloxacin was highly active against 683 strains (70.41%), had intermediate activity against 109 (11.23%) and had no activity against 178 (18.35%). ofloxacin was highly active against e. coli, klebsiella sp., citrobacter sp., proteus mirabilis, proteus morganii, salmonella sp., camp ... | 1987 | 3476290 |
| antibacterial effect of imipenem in vitro against important aerobic and anaerobic strains isolated from clinical specimens. | imipenem is a thienamycin antibiotic of the first generation with broad antibacterial activity. it covers all gram-positive organisms (including streptococcus faecalis) and gram-negative bacteria (including pseudomonas aeruginosa and serratia spp.) as well as bacteroides fragilis and other bacteroides species. in this comparative study the antimicrobic effect against 1020 gram-negative, 927 gram-positive and 352 anaerobic strains from fresh clinical isolates was tested and compared with that of ... | 1987 | 3477332 |
| concentration of pefloxacine in split ejaculates of patients with chronic male accessory gland infection. | the concentrations of pefloxacine and its n-demethylated derivative were measured in split ejaculates of 12 patients with chronic male accessory gland infection during treatment with 400 mg. pefloxacine twice a day. the mean concentrations of pefloxacine and n-demethylated pefloxacine (mg. per l.) were 8.7 +/- 1.2 (standard error of the mean) and 4.2 +/- 0.7 in fraction 1, and 9.8 +/- 1.1 and 4.3 +/- 0.6 in fraction 2. the concentrations in both fractions were correlated strongly (r equals 0.97) ... | 1987 | 3477650 |
| efficacy and tolerance of oral ofloxacin in treating various infections. | 66 patients were given daily doses of ofloxacin between 400 and 800 mg for 10 days to 6 months. they were suffering from exacerbation of chronic bronchitis (15), soft tissue phlegmon (11), complicated urinary tract infections (7), bronchopneumonia (7), chronic osteomyelitis in exacerbation (8), chronic prostatitis in exacerbation (5), lower urinary tract infections (3), chronic otitis media (3), acute otitis (3), acute bronchitis (1), lung abscess (2) or liver abscess (1). pathogens included pse ... | 1987 | 3481312 |
| chemotherapy of otitis media with ofloxacin. | this study evaluated the therapeutic role of ofloxacin in different forms of otitis media. after identifying the infecting bacteria in 250 patients with acute otitis media, or chronic otitis media, the clinical efficacy of orally administered ofloxacin 200mg twice daily was assessed in 45 patients from each of these groups. the clinical results were comparable with those obtained after conventional local and oral antibiotic therapy. microbiological examination of the ear secretions revealed stap ... | 1987 | 3481314 |
| antimicrobial activity and beta-lactamase stability of sk&f 88070 compared with other agents. | the in vitro activity and beta-lactamase stability of sk&f 88070 (7-[[2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[ [1-(2-sulfaminoethyl)-1h-tetrazol-5-yl]thio]methyl]-3- cephem-4-carboxylic acid) a new parenteral cephalosporin was investigated against 780 types of bacteria. sk&f 88070 inhibited 90% of escherichia coli, klebsiella pneumoniae, proteus mirabilis, salmonella species, shigella species, morganella morganii, and citrobacter diversus at less than or equal to 0.5 micrograms/ml. i ... | 1986 | 3485506 |
| the activity of bmy 28142 a new broad spectrum beta-lactamase stable cephalosporin. | the in-vitro activity of bmy 28142, an iminomethoxy, aminothiazolyl cephalosporin containing a methyl pyrrolidinio c-3 was compared with that of cefotaxime, ceftazidime, aztreonam, imipenem and tobramycin against various bacteria. bmy 28142 was the most active agent tested against the enterobacteriaceae inhibiting 90% at less than or equal to 1 mg/l. the in-vitro activity of bmy 28142 was equal to or superior to cefotaxime against the highly susceptible members of the enterobacteriaceae and seve ... | 1986 | 3486862 |
| synergism and antagonism in double beta-lactam antibiotic combinations. | combinations of two beta-lactam antibiotics may be advantageous in certain clinical situations, providing a synergistic activity against specific organisms or a broad spectrum of antibiotic coverage. depending on the combination and the bacteria, synergism, indifference, or antagonism can be observed. synergism may occur when two beta-lactam antibiotics, acting on different penicillin-binding proteins, are combined or when a penicillinase-susceptible beta-lactam antibiotic is protected by anothe ... | 1986 | 3487247 |
| timentin and beta-lactamases. | ticarcillin is resistant to the action of cephalosporinases, which explains its biological activity on a large number of bacterial species, including cephalosporinase-producing enterobacteriaceae and pseudomonas aeruginosa. nevertheless, its antibacterial activity is often limited by the action of some beta-lactamases, mostly plasmid-mediated penicillinases. clavulanic acid by itself has poor antibacterial activity, but its most important property is to inhibit and inactivate beta-lactamases. th ... | 1986 | 3487538 |
| resistance to beta-lactams in enterobacteriaceae: distribution of phenotypes related to beta-lactamase production. | phenotypes of susceptibility to amoxycillin (amo), ticarcillin (tic), cephalothin (ctn) were determined in 1366 isolates of enterobacteriaceae by disk method and beta-lactamases were identified in 243 strains belonging to different phenotypes of amoxycillin-resistant strains. amor ticr ctns strains (25%) were penicillinase producers and all of them were susceptible to the combination amoxycillin/clavulanic acid (amo/ca) and ticarcillin/clavulanic acid (tic/ca). amo1/r tics ctnr strains (12%) wer ... | 1986 | 3489648 |
| purification and properties of a beta-lactamase from proteus penneri. | a cephalosporin-hydrolyzing enzyme from strains of proteus penneri resistant to beta-lactam antibiotics was purified and characterized. the enzyme gave a single protein band on sds-polyacrylamide gel electrophoresis with a molecular weight of 30,000. this cephalosporinase has an isoelectric point of 6.8, a ph optimum of 6.5 and a temperature optimum of 45 degrees c. the enzyme hydrolyzed cephaloridine, cephalothin, cefuroxime, and cefotaxime more rapidly than penicillins. the relative rate, with ... | 1986 | 3489701 |
| norfloxacin versus co-trimoxazole in the treatment of recurring urinary tract infections in men. | norfloxacin is a lipid-soluble weak organic acid bound to plasma proteins to a low extent. norfloxacin has a pka1 from 6.2 to 6.4 and a pka2 from 8.7 to 8.9. mean concentrations of norfloxacin in prostatic tissue have been reported as 1.7 mg/kg. recurrent urinary tract infection (uti) in men is frequently associated with prostatic infection, and chronic prostatitis is both difficult to diagnose and to treat. one hundred and twenty-nine patients were entered into a randomized, open controlled, co ... | 1986 | 3490684 |
| in vitro activity and beta-lactamase stability of two oral cephalosporins, ceftetrame (ro 19-5247) and cefetamet (ro 15-8074). | ceftetrame (ro 19-5247) and cefetamet (ro 15-8074), two new orally administered aminothiazolyl imimomethoxy cephalosporins, inhibited hemolytic streptococci and streptococcus pneumoniae at less than or equal to 0.5 micrograms/ml but were less active against staphylococci than were cephalexin and cefaclor. they did not inhibit s. faecalis, s. faecium, listeria monocytogenes, corynebacterium jk species, or pseudomonas aeruginosa. haemophilus influenzae, branhamella catarrhalis, and neisseria gonor ... | 1986 | 3490827 |
| effect of changing selection pressures on trimethoprim resistance in enterobacteriaceae. | the incidence of trimethoprim resistance was correlated with changes in prescription behaviour in the nottingham area from 1978-1985. the prevalence of trimethoprim resistance among enterobacteriaceae isolated from patients with urinary tract infection rose from 5% to 15% of total strains examined. strains resistant to trimethoprim but susceptible to sulfamethoxazole appeared from 1980 onward and represented 35% of the total trimethoprim-resistant strains examined in 1985. co-trimoxazole (trimet ... | 1986 | 3490973 |
| in vitro activity and beta-lactamase stability of a new difluoro oxacephem, 6315-s. | 6315-s, a novel difluoromethyl thioacetamido oxacephem, had in vitro activity comparable to that of cefotaxime and moxalactam against escherichia coli, klebsiella pneumoniae, proteus mirabilis, klebsiella oxytoca, citrobacter diversus, salmonella spp., and shigella spp., inhibiting 90% at less than or equal to 0.25 microgram/ml. it inhibited piperacillin- and cefoperazone-resistant isolates in these species. 6315-s did not inhibit cefotaxime- or moxalactam-resistant citrobacter freundii, enterob ... | 1986 | 3492172 |
| beta-lactamase stability of cefpirome (hr 810), a new cephalosporin with a broad antimicrobial spectrum. | cefpirome was highly stable to hydrolysis by various beta-lactamases, although it was hydrolyzed to some extent by r plasmid-mediated penicillinase of richmond-sykes type va/b and by chromosomal cephalosporinases from bacteroides species. the compound had a very low affinity for cephalosporinases from enterobacter cloacae, citrobacter freundii, serratia marcescens, and proteus vulgaris. cefpirome showed strong antimicrobial activity against eight beta-lactamase (cephalosporinase)-producing strai ... | 1986 | 3492175 |
| stones in the urinary bladder in children and young adults. | bladder stones were diagnosed in 22 children and young adults at the children's hospital, boston, from 1969 to 1985. one half of the patients were less than 12 years old (mean, 11.9 years). one or more lithogenic factors were implicated in all but two. the most common causes were the presence of an intravesical foreign body, infection with proteus (a urea-splitting organism), exstrophy of the bladder, and the presence of intestinal mucosa in the urinary tract. the radiologic features of the ston ... | 1987 | 3492874 |
| beta-lactamase stability of imipenem. | the beta-lactamase stability and interactions of imipenem were analysed in comparison with those of cefazolin, cefuroxime, cefoxitin, cefotaxime, ceftazidime, mezlocillin, piperacillin and penicillin g for a set of representative beta-lactamases. these enzymes included penicillinases such as those obtained from staphylococcus aureus, escherichia coli and other enterobacteriaceae (tem-1 and similar enzymes) (group a); cephalosporinases produced by esch. coli (amp c type), serratia liquefaciens, e ... | 1986 | 3493236 |
| [immunopathology of htlv iii infection in drug addicts]. | the authors are herewith reporting the results of an immunological screening performed on 15 drug addicts presenting serological positivity for anti htlv iii (elisa and wb). the study has been carried out determining populations and subpopulations of lymphocytes (t3, t4, t8 and t4/t8) and performing cutaneus tests with multiple antigens (tetanus--candida--diphtheria--proteus--streptococcus and tricophyton). the results achieved by mean of the above mentioned tests seem to indicate the presence o ... | 1986 | 3493791 |
| in vitro activity and beta-lactamase stability of a new penem, cgp 31608. | the in vitro activity of cgp 31608, a new penem, against aerobic and anaerobic organisms was evaluated and compared with those of other beta-lactams. cgp 31608 inhibited escherichia coli, klebsiella pneumoniae, k. oxytoca, proteus mirabilis, citrobacter diversus, and salmonella, shigella, aeromonas, and yersinia spp. with mics for 50% of the strains (mic50s) of 2 to 4 micrograms/ml and mic90s of 4 micrograms/ml, compared with cefotaxime, ceftazidime, aztreonam, and imipenem mics of less than 0.2 ... | 1987 | 3496845 |
| comparative activity of ceftizoxime against aminoglycoside-resistant aerobic gram-negative bacilli. | the in vitro activity of ceftizoxime was compared with that of other beta-lactam antibiotics against 331 aminoglycoside (ag)-resistant clinical isolates. two hundred and six ag-resistant, beta-lactamase producing, r-plasmid harbouring enterobacteriaceae strains had mics ranging from 0.0125 to 0.063 mg/l. ag-resistant escherichia coli (36 strains) and klebsiella pneumoniae (19) had mic 90 values of 8 mg/l. proteus rettgeri and p. vulgaris as well as morganella morganii, resistant to several ags, ... | 1987 | 3497792 |
| in vitro activity of cefixime and six other agents against nosocomial pathogens of the enterobacteriaceae family. | cefixime, a broad-spectrum, orally active cephalosporin, was more active in vitro than ampicillin, cefaclor, cephalothin, and trimethoprim/sulfamethoxazole against 194 nosocomial pathogens of the family enterobacteriaceae. activity was especially good against klebsiella spp, proteus spp, serratia spp, and providencia stuartii. although gentamicin had equivalent or better activity against citrobacter spp, enterobacter spp, escherichia coli, and morganella morganii, all 23 of the gentamicin-resist ... | 1987 | 3498702 |
| in vitro and in vivo evaluations of bmy-28100, a new oral cephalosporin. | a new semisynthetic oral cephalosporin, bmy-28100, was evaluated for in vitro and in vivo antibacterial activities in comparison with cefaclor and cephalexin. bmy-28100 showed in vitro activity 3- and 10-fold more potent than that of cefaclor against staphylococcus aureus and streptococcus pneumoniae, respectively. bmy-28100 was slightly better than cefaclor and about 4 times more active than cephalexin against haemophilus influenzae and neisseria gonorrhoeae. escherichia coli, klebsiella pneumo ... | 1987 | 3500158 |
| beta-lactamase of pseudomonas pseudomallei and its contribution to antibiotic resistance. | beta-lactamase production was examined in nine strains of pseudomonas pseudomallei isolated from human, animal and environmental sources in thailand and hong kong. all produced the same weakly inducible, membrane associated chromosomal cephalosporinase, which had a molecular weight of 29,500 and an isoelectric point of 7.4-7.7. the enzyme resembled the cefuroximases of ps. cepacia and proteus vulgaris, but differed from the class i cephalosporinases typical of ps. aeruginosa and most enterobacte ... | 1987 | 3500161 |