| comparison between indirect fluorescent antibody and weil-felix tests for detecting antibodies against rickettsia. | comparative evaluation of indirect fluorescent antibody test (ifat) and weil-felix test (wft) was carried out for detecting rickettsial antibodies in 102 patients with pyrexia of unknown origin (p.u.o.), 20 brucellosis cases and 20 normal healthy controls (n.h.c.). of 102 sera of cases with p.u.o., antibodies against rickettsia could be detected in 11 (10.7 per cent) cases by ifat and in 10 (9.8 per cent) cases by wft, but amongst these 10 sera, antibodies could be detected only in six by ifat. ... | 1991 | 1940221 |
| palladium, platinum, cadmium, and mercury complexes with neutral isoorotic and 2-thioisoorotic acids: ir and nmr spectroscopies, thermal behavior and biological properties. | seven complexes containing neutral isoorotic and 2-thioisoorotic acids, as well as thiocyanate and chloride anions as lignands, have been synthesized and characterized by means of both spectral (ir, 1h, and 13c nmr) and thermal (tg and dsc) methods, as well as conductivity measurements. spectral data suggest that any binding metal-ligand mode for uracil derivatives is not easy to propose. therefore, isoorotic ligands must link through some oxygen atom. likewise, 2-thioisoorotic acid seems to be ... | 1991 | 1940899 |
| the production and activity in vivo of proteus mirabilis iga protease in infections of the urinary tract. | immunoblotting of urine from 21 patients of both sexes and of wide age range who had a proteus mirabilis urinary tract infection (uti) showed that 14 (64%) specimens contained immunoglobulin a (iga). in nine (64%) of these the iga heavy chain had been degraded to fragments of a size identical to those formed when purified iga was degraded by pure p. mirabilis protease. urine from patients with clinical evidence of upper uti contained fragmented iga and in some of these urine samples p. mirabilis ... | 1991 | 1941989 |
| nucleotide sequence of dihydrofolate reductase type vi. | the complete sequence of the type vi dihydrofolate reductase (dhfr) gene from plasmid puk672 was determined. the structural gene coded for a polypeptide of 157 amino acids which had a deduced mol. wt of 17,424. comparison with amino-acid sequences of the type i, type v and escherichia coli k12 chromosomal dhfrs showed that there was 63%, 61% and 31% homology respectively. putative rna polymerase and ribosomal binding sites were identified proximal to the initiation codon and a feature consistent ... | 1991 | 1941991 |
| crystallization and crystal packing of proteus mirabilis pr catalase. | the tetrameric catalase from proteus mirabilis pr (ec 1.11.1.6), known to bind nadph, has been crystallized by the hanging-drop method in a form apparently depleted in dinucleotide. the crystals belong to the hexagonal space group p6(2)22 with a = b = 111.7 a, c = 248.8 a. there is one subunit in the asymmetric unit. data were collected to 2.9 a at the l.u.r.e. (orsay) synchrotron radiation facility. the tetramers have been located in the crystal, centered on the site (1/2, 0, 0) with 222 symmet ... | 1991 | 1942042 |
| uropathogens of various childhood populations and their antibiotic susceptibility. | to define the uropathogens of various childhood populations and their antibiotic susceptibility, 646 episodes of urinary tract infections (uti) were studied. of the community-acquired uti 78% were caused by escherichia coli and 12% by klebsiella whereas only 65% of hospital-acquired uti were caused by e. coli (p less than 0.01), and other pathogens, including pseudomonas, were more common. in children with uti who did not have an underlying disorder, most infections were caused by e. coli and kl ... | 1991 | 1945576 |
| nephrobronchial fistula. case report. | a 26-year-old woman presented with a six-year history of right staghorn calculus and pyonephrosis. intravenous pyelography showed a non-functioning right kidney and chest radiography, an elevated right hemidiaphragm and fluid in the right costaphrenic space. at operation a nephrobronchial fistula was found, and nephrectomy and subdiaphragmatic drainage of the lung abscess was carried out. culture of the pus grew proteus mirabilis. the patient made an uneventful recovery and was discharged on the ... | 1991 | 1947857 |
| combined anaerobic and coliform infection in acute dacryocystitis. | | 1991 | 1955969 |
| [renal calculi in an infant]. | urinary concretions, particularly in the upper urinary tract, occur in otherwise healthy children in connection with bacillus proteus urinary infections. in other european countries, this occurs in 40-70% while, on the other hand, it is particularly rare in scandinavia. a case of obstructing pelvic concretion in a boy aged three months is presented. this is the youngest case which could be found in the literature. pyelolithotomy was performed and the child has been free from recurrence for six y ... | 1991 | 1957378 |
| antibiotic sensitivity pattern; experience at university hospital, riyadh, saudi arabia. | results of sensitivity testing were discussed based on examination of 5192 isolates of the various bacteria isolated from clinical specimens from king khalid university hospital in riyadh, saudi arabia. streptococcus pyogenes and streptococcus pneumoniae were sensitive to penicillin and erythromycin. the sensitivity pattern of staphylococcus aureus was also predictable as they were fairly sensitive to both methicillin (98%) and erythromycin (96%). neisseria gonorrhoeae (27%) showed a high level ... | 1991 | 1960392 |
| [antibacterial activities of ofloxacin against recent isolates from patients with community-acquired infections]. | in order to survey antibacterial activities of ofloxacin (oflx) against 1,440 bacterial strains isolated from patients with community-acquired infections in 1987 and 1990, minimum inhibitory concentrations (mics) of the drug as well as those of other new quinolones and oral cephems were determined. the following conclusions were reached. 1. comparison of the mic distribution for strains isolated in 1987 with those in 1990 suggested a tendency toward an increase in the frequency of oflx-resistant ... | 1991 | 1960856 |
| factitious disorder with respiratory symptoms. | | 1991 | 1961864 |
| the imaging of body asymmetry and hemihypertrophy. | localized soft tissue and bone overgrowth may be the result of many different causes and will vary in severity, from involvement of a single digit to one half of the body. there are a variety of causes, including chronic lymphedema; lymphangiomatous malformations; neurofibromatosis; vascular malformations including the klippel-trenaunay-weber syndrome; macrodystrophia lipomatosa; multiple enchondromatosis and maffucci's syndrome. more recently, the bannayan syndrome and the proteus syndrome have ... | 1990 | 1963062 |
| [an intravesical foreign body--the cause of chronic pyelonephritis in a child]. | the paper reports on a case of chronic pyelonephritis with bacillus proteus, generated by an intravesical foreign body (sewing needle). the needle was extracted with surgical cystoscope. after removing the foreign body, nalidixic acid was administered. the immediate evolution of the case was good. | 1990 | 1966514 |
| tissue-binding affinity of proteus mirabilis fimbriae in the human urinary tract. | binding characteristics of the two major fimbrial hemagglutinin types of uropathogenic proteus mirabilis were determined in frozen sections of human kidney and in exfoliated uroepithelial cells. p. mirabilis 3087, which expresses the mr/p fimbriae, adhered avidly to the tubular epithelial cells of the kidney and also to the epithelial cells of urinary sediment. no adhesion to glomerular or peritubular elements of the kidney was detected. indirect immunogold silver staining also showed that the p ... | 1990 | 1976113 |
| female urinary tract infection in primary health care: bacteriological and clinical characteristics. | female patients with symptoms of urinary tract infection (n = 1136) were studied in primary health care with respect to (a) clinical symptoms as predictors of bacteriuria; (b) relation between aetiological agent and clinical picture, especially for p-fimbriated escherichia coli; and (c) clinical findings in cases with 10(2)- less than 10(5) cfu/ml of e. coli. prevalence of bacteriuria (greater than or equal to 10(5) cfu/ml) was 61%. concurrence of urgency/frequency and dysuria, short duration of ... | 1990 | 1977196 |
| lactate dehydrogenase isoenzyme electrophoresis as a typing method for enterobacter cloacae, klebsiella oxytoca and proteus mirabilis. | | 1990 | 1979580 |
| [the effect of catecholaminergic agents on the efficacy of immunostimulants]. | the influence of combinations of immunostimulants (prodigiosin, methyluracil, levamisole) and catecholaminergic agents (dopamine, haloperidol, noradrenaline, phentolamine, isoproterenol, propranolol) on the results of antibiotic therapy of acute generalized proteus infection and primary immune response to ram erythrocytes was studied on outbred albino mice. it was established that the agents influencing dopaminergic, alpha- and beta-adrenergic receptors can in some cases change the efficiency of ... | 1990 | 1981988 |
| a rodent model of cirrhosis, ascites, and bacterial peritonitis. | we sought to develop a rodent model of spontaneous bacterial peritonitis and report here the preliminary results of carbon tetrachloride-induced cirrhosis in which ascites and bacterial peritonitis predictably develop. of 41 rats that survived the initial carbon tetrachloride toxicity, 38 (92.7%) developed cirrhosis with ascites. of these 38, 21 (55.3%) developed 24 episodes of ascitic fluid infection without iatrogenic colonization. no surgically treatable source of infection was identified at ... | 1991 | 1985046 |
| bacterial killing in vitro by abscess-derived neutrophils. | in the absence of antimicrobial therapy, bacteria such as bacteriodes fragilis, escherichia coli and proteus mirabilis may persist within an intra-abdominal abscess in the presence of large numbers of neutrophils which, under optimal conditions in vitro, can readily phagocytose and kill the same bacterial strains. neutrophils taken from abscesses induced by gram-negative bacteria such as those above contain viable organisms. on incubation in vitro in the presence of serum, these neutrophils kill ... | 1991 | 1990143 |
| production and characterization of a monoclonal antibody specific for enterohemorrhagic escherichia coli of serotypes o157:h7 and o26:h11. | a monoclonal antibody (mab 4e8c12) specific for escherichia coli o157:h7 and o26:h11 was produced by immunizing balb/c mice with a rough strain of e. coli o157:h7. the antibody reacted strongly by a direct enzyme-linked immunosorbent assay with each of 36 strains of e. coli o157:h7. no cross-reactivity was observed with strains of salmonella spp., yersinia enterocolitica, shigella dysenteriae, proteus spp., escherichia hermanii, klebsiella pneumoniae, campylobacter jejuni, serratia marcescens, c ... | 1991 | 1993773 |
| measurement of urinary lipopolysaccharide antibodies by elisa as a screen for urinary tract infection. | five hundred and twenty two clinical urine specimens submitted for routine microbiological examination were tested in parallel by conventional microscopy and culture and for lipopolysaccharide antibodies by an enzyme linked immunoabsorbent assay (elisa) to assess the elisa as a screen for urinary tract infection. when the elisa alone was compared with routine methods the specificity sensitivity, and predictive value of positive and negative tests was 73.2%, 75.7%, 51.1% and 38.5%. for elisa with ... | 1991 | 1997536 |
| role of phenytoin in healing of large abscess cavities. | the promotion of healing of large abscess cavities attained with topical phenytoin was evaluated in controlled studies of clinical and experimental wounds. in the clinical abscess cavities, phenytoin application in 20 patients compared with conventional treatment in 20 patients resulted in earlier separation of slough, decrease in oedema, control of pain and overall enhanced healing. the mean(s.d.) rate of reduction of wound area was 2.02(0.48) cm2/day in the phenytoin group versus 1.58(0.51) cm ... | 1991 | 1998849 |
| intravenous ciprofloxacin versus ceftazidime for treatment of nosocomial pneumonia and urinary tract infection. | intravenous ciprofloxacin and ceftazidime were compared for efficacy in the treatment of nosocomial pneumonia and urinary tract infection (uti). patients with nosocomial pneumonia were randomized to receive ciprofloxacin (as the lactate salt) 300 mg i.v. every 12 hours or ceftazidime (with sodium carbonate) 2 g i.v. every eight hours. patients with uti were randomized to receive ciprofloxacin 200 mg i.v. every 12 hours or ceftazidime 1 g i.v. every eight hours. sputum and urine specimens were co ... | 1991 | 1999086 |
| dependence of lysozyme-catalysed solubilization of proteus mirabilis peptidoglycan on the extent of o-acetylation. | the degree of peptidoglycan o-acetylation in 14 strains of proteus mirabilis has been accurately determined by a procedure which employs the quantitation of mild-base-released acetic acid by hplc, and the estimation of peptidoglycan concentration by cation-exchange amino acid analysis. the beta-d-n,6-o-diacetylmuramyl content of all isolated and purified peptidoglycans was ranged 20-52.8%, relative to the total muramic acid concentration. each of the o-acetylated peptidoglycans was found to be r ... | 1991 | 1999194 |
| freeze-substitution of gram-negative eubacteria: general cell morphology and envelope profiles. | freeze-substitution was performed on strains of escherichia coli, pasteurella multocida, campylobacter fetus, vibrio cholerae, pseudomonas aeruginosa, pseudomonas putida, aeromonas salmonicida, proteus mirabilis, haemophilus pleuropneumoniae, caulobacter crescentus, and leptothrix discophora with a substitution medium composed of 2% osmium tetroxide and 2% uranyl acetate in anhydrous acetone. a thick periplasmic gel ranging from 10.6 to 14.3 nm in width was displayed in e. coli k-12, k30, and hi ... | 1991 | 1999383 |
| shuttle cloning and nucleotide sequences of helicobacter pylori genes responsible for urease activity. | production of a potent urease has been described as a trait common to all helicobacter pylori so far isolated from humans with gastritis as well as peptic ulceration. the detection of urease activity from genes cloned from h. pylori was made possible by use of a shuttle cosmid vector, allowing replication and movement of cloned dna sequences in either escherichia coli or campylobacter jejuni. with this approach, we cloned a 44-kb portion of h. pylori chromosomal dna which did not lead to urease ... | 1991 | 2001995 |
| paediatric urolithiasis in greece. | a group of 44 patients, aged from 10 months to 14 years, underwent surgery for urinary calculi over a 7-year period (1982-1989). eleven patients had bilateral or multiple calculi (total number of stones = 55, 20 of which were staghorn). metabolic disorders (n = 25) and proteus urinary infection (n = 15) were the 2 factors most often associated with lithiasis. of the 55 stones, 51 were removed by open surgery. complete stone clearance was achieved in 29 of 36 kidneys. follow-up periods in the rem ... | 1991 | 2004238 |
| eyelid tumors in the proteus syndrome. | | 1991 | 2012164 |
| purification and characterization of a novel glutathione transferase from serratia marcescens. | four forms of glutathione transferase were resolved from the cytosol of serratia marcescens cip 6755 by gsh-affinity chromatography followed by isoelectric focusing. the major isoenzyme, named sm-gst-7.3, is composed of two subunits each with a molecular mass of 22 kda and has an isoelectric point at ph 7.3. sm-gst-7.3, appears to be distinct from pm-gst-6.0, previously characterized from proteus mirabilis af 2924 as indicated by its substrate specificity, immunological reactivity, subunit molec ... | 1991 | 2015287 |
| the structure of the o-specific polysaccharide chain of proteus penneri strain 16 lipopolysaccharide. | o-specific polysaccharide was obtained by mild acid degradation of proteus penneri strain 16 lipopolysaccharide and found to contain d-glucose, d-glucuronic acid, 2-acetamido-2-deoxy-d-glucose, and 3,6-dideoxy-3-[(r)-3-hydroxybutyramido]- d-galactose in the ratio of 2:1:1:1 as well as a small proportion of o-acetyl groups. on the basis of one-dimensional 1h-nmr13c-nmr and noe spectroscopy, two-dimensional homonuclear-shift-correlated spectroscopy with one-step and two-step relayed coherence tran ... | 1991 | 2015828 |
| dihydrotetramethylrosamine: a long wavelength, fluorogenic peroxidase substrate evaluated in vitro and in a model phagocyte. | dihydrotetramethylrosamine, a fluorogenic substrate for peroxidase, and its fluorescent oxidation product, tetramethylrosamine chloride, were evaluated. the substrate is colorless and nonfluorescent while the oxidized dye absorbs at 550 nm and emits at 574 nm in both methanol and water. in vitro assays demonstrated that the substrate was oxidized to the fluorophore by horseradish peroxidase in the presence of hydrogen peroxide. in vivo uptake and oxidation of the substrate by amoeba proteus was ... | 1991 | 2018489 |
| aerobic bacteria from nasal discharge of goats suffering from clinical ppr: isolation and identification. | bacteriological isolation of aerobic bacteria from nasal discharge of achondroplastic west african dwarf goats showing clinical signs of peste des petits ruminants (ppr), and the laboratory procedures carried out for the identification of the isolates are described. from a total of forty nasal swabs obtained seventy five isolates were recovered. the percentage frequency of isolation of different organisms in descending order of occurrence is as follows: staphylococcus 44.0%; streptococcus 22.67% ... | 1991 | 2023545 |
| in vitro activity and beta-lactamase stability of gr69153, a new long-acting cephalosporin. | gr69153, a new parenteral cephalosporin, inhibited 90% of escherichia coli, klebsiella oxytoca, proteus mirabilis, citrobacter diversus, shigellae, and salmonellae at less than 0.25 micrograms/ml (mic90). it had activity comparable to those of ceftazidime, cefpirome, cefepime, and e-1040. against cephalosporinase-producing enterobacter cloacae, citrobacter freundii, and serratia marcescens, mics ranged from 0.12 to greater than 32 micrograms/ml, and cefpirome and cefepime were the most active ag ... | 1991 | 2024959 |
| [experimental and clinical studies of drug regulation of the anti-lysozyme activity of microorganisms causing opportunistic infections]. | experimental materials on choosing antibiotics for etiotropic therapy of opportunistic infections with an account of the regulating effect of the drugs on the ++anti-lysozyme activity of pathogens (the factor of intracellular parasitism) are presented. the in vitro data were applied to the clinical trials in 30 patients with chronic and acute pyelonephritis of the proteus etiology and to 25 patients with chronic inflammatory diseases of staphylococcus etiology. it was shown that the use of the a ... | 1991 | 2025109 |
| aztreonam for treating meningitis caused by gram-negative rods. | 10 patients with meningitis due to unusual gram-negative organisms (pseudomonas, proteus, salmonella and klebsiella) were effectively treated with aztreonam. a detailed history and a thorough physical examination combined with careful laboratory testing resulted in accurate diagnosis and cure of all patients. | 1991 | 2028226 |
| increased urinary nitrosamine excretion in paraplegic patients. | an increased risk of bladder cancer is a recognized complication in spine-injured patients undergoing long-term urethral catheterization to preserve renal function. aerobic cultures from 28 of 30 paraplegic patients showed complex bacterial flora containing nitrate-reducing organisms (escherichia coli, proteus and klebsiella spp.). urine samples from 29 paraplegic patients were also found to contain volatile nitrosamines. mean n-nitrosamine excretion levels were 0.65 +/- 0.69 micrograms/day n-ni ... | 1991 | 2029761 |
| susceptibility of female pelvic pathogens to oral antibiotic agents in patients who develop postpartum endometritis. | fifteen hundred patients were enrolled in a prospective, randomized study on the effect of antibiotic prophylaxis during cesarean section. two hundred thirty-one patients developed postpartum endometritis, and the isolates obtained from the endometrium were tested for sensitivity to ampicillin, cefuroxime, ofloxacin, ciprofloxacin, and clindamycin. minimum inhibitory concentrations of 50% and 90% of ampicillin, cefuroxime, and clindamycin were similar to previously reported values; however, slig ... | 1991 | 2031518 |
| cytotoxicity of the hpma hemolysin and urease of proteus mirabilis and proteus vulgaris against cultured human renal proximal tubular epithelial cells. | proteus mirabilis, a common agent of nosocomially acquired and catheter-associated bacteriuria, can cause acute pyelonephritis. in ascending infections, bacteria colonize the bladder and ascend the ureters to the proximal tubules of the kidney. we postulate that proteus species uses the hpma hemolysin and urease to elicit tissue damage that allows entry of these bacteria into the kidney. to study this interaction, strains of proteus mirabilis and p. vulgaris and their isogenic hemolysin-negative ... | 1991 | 2037363 |
| relationship between urease-producing bacteria, urinary ph and encrustation on indwelling urinary catheters. | in 11 patients with long-term indwelling catheters the amount of catheter encrustation and urinary ph were measured and the urine regularly cultured over a prolonged period of time (median of 7 periods of 3 weeks). the mean urinary ph was related to the persistent presence of urease-producing micro-organisms (p. mirabilis) and urinary ph governed the precipitation of catheter encrustation. the critical ph appeared to be around 6.8. in patients with a mean urinary ph below this level the encrusta ... | 1991 | 2039922 |
| [antibacterial activity of ciprofloxacin against fresh clinical isolates from superficial suppurative foci]. | the minimum inhibitory concentrations (mics) of 5 drugs (ciprofloxacin (cpfx), and 4 drugs used as standard) were determined to investigate antibacterial potencies of cpfx against bacterial strains isolated in 1989 from superficial suppurative foci. the clinical isolates tested included 375 strains from 11 aerobic bacterial species, and 50 strains from 2 anerobic bacterial genera (group) for a total of 425 isolates. interpreting mic level distributions of these drugs as the expression of antibac ... | 1991 | 2041153 |
| [antimicrobial susceptibilities of clinical isolates of morganella-proteus-providencia group of bacteria]. | we examined in vitro susceptibilities of 3,109 isolates belonging to 5 species of proteeae to 2 penicillins, 5 cephems and 2 aminoglycosides. the isolates were collected from 69 hospital laboratories throughout japan between 1986 and 1988. minimal inhibitory concentrations were determined using the agar dilution method with inoculation of 10(8) cells/ml of bacteria. proteus mirabilis had marked susceptibilities to the penicillins and cephems tested. proteus vulgaris and morganella morganii were ... | 1991 | 2041155 |
| [preoperative microbiologic diagnosis before elective intraocular interventions and prevention of infection with tobramycin eyedrops. results of a multicenter study]. | preoperative conjunctival smears of 313 asymptomatic patients before cataract surgery were evaluated in an open multi-center study in 10 german surgical eye care centers from may to august 1987. 230 evaluable isolates of 198 patients (= 61.1%) on agar plates with a 48 h incubation period revealed 190 gram-positive (most frequent isolates: 62.2% coagulase negative staph., 13.5% coagulase positive staph.) and 40 gram negative agents (most frequent isolates: 3.0% proteus sp., 2.2% pseudomonas sp.). ... | 1991 | 2041373 |
| [perioperative risk of infection in cataract surgery]. | the presence of bacteria during cataract surgery was studied on 71 consecutive patients. lid and conjunctival smears were cultured 24 hours preoperatively. additional conjunctival smears were harvested in the operating room before and after conjunctival disinfection by oxycyanate. moreover, the whole irrigation fluid was collected under sterile condition and examined microbiologically. 24 hours preoperatively 61 of 71 patients had positive cultures of their lids and/or conjunctivae. 8 of them sh ... | 1991 | 2041374 |
| [neonatal conjunctivitis in a nursery and a neonatal unit]. | after credé prophylaxis was abandoned at our hospital in 1984 scrupulous clinical surveillance of all neonates for conjunctivitis, and bacterial cultures from purulent eye discharge, have become routine. during the two-year period 1 march 1987 to 28 february 1989, testing for chlamydia trachomatis (eia-technique) was added in all infants with clinical conjunctivitis. during the period concerned there were 332 cases of conjunctivitis among 4,520 live born infants, an incidence of 7.3%. the incide ... | 1991 | 2042130 |
| [microbiological quality of mechanically deboned beef]. | microbial quality of mechanically deboned beef (mdb), which was obtained by the discontinuous hydraulic horizontal separator, type inject-star (firm laska, austria), was analyzed for the presence of indicatory microorganisms (coliforms and enterococci), pathogenic and conditionally pathogenic microorganisms. the basic microbial parameters have been determined separately for mdb of 1st, 2nd degrees as well as for average daily samples from one collecting vessel. apart from it, also a raw material ... | 1991 | 2042400 |
| bacterial antibodies in ankylosing spondylitis. | antibodies to salmonellae, yersiniae, campylobacter jejuni, borrelia burgdorferi, klebsiella pneumoniae, escherichia coli, proteus mirabilis and chlamydia trachomatis were measured by elisa in the sera of 99 patients with ankylosing spondylitis. increased prevalence of iga and igg class antibodies against k. pneumoniae and of iga class against e. coli was observed in ankylosing spondylitis. no clear correlation between the disease activity and occurrence of antibodies was revealed. the results a ... | 1991 | 2044228 |
| characterization of cell-bound and cell-free hemolytic activity of proteus strains. | the relationship between growth condition and production of cell-bound hemolysin by proteus mirabilis s1959 strain was investigated. hemolytic activity was not dependent on type of medium, oxygen accessibility and was inhibited in presence of n-ethylmaleimide, different sera or trypsine. cell-free hemolysin was released to the medium during stationary-death phases of growth of fluid proteus mirabilis and vulgaris cultures. | 1991 | 2044713 |
| pore-forming cytolysins of gram-negative bacteria. | a great deal is known about the structure, function and metabolic effects of enzymatic bacterial toxins such as the diphtheria, pertussis and cholera toxins. by comparison, our understanding of the pore-forming, cytolytic toxins, particularly those produced by gram-negative bacterial pathogens, is far less complete. the genetics and biochemistry of a large, newly discovered family of calcium-dependent, pore-forming cytotoxins (rtx toxins) produced by different genera of the enterobacteriaceae an ... | 1991 | 2046545 |
| open randomized controlled parallel study of ofloxacin versus trimethoprim-sulfamethoxazole treatment of lower respiratory tract and urinary infections. | a total of 60 patients with lower respiratory tract or urinary tract infections were enrolled in an open, randomized, controlled, parallel study comparing 300 mg ofloxacin (ofx) b.i.d. with trimethoprim + sulfamethoxazole (tmp 800 mg + smx 160 mg), 1 tablet, b.i.d. the signs and symptoms of low respiratory tract infection were cured in 12 patients (80%) of the ofx group and improved in 2 other patients (13%); at the end of therapy, the 2 germs that persisted were streptococcus pneumoniae and bra ... | 1991 | 2049964 |
| the efficacy of polysporin first aid antibiotic spray (polymyxin b sulfate and bacitracin zinc) against clinical burn wound isolates. | polysporin first aid antibiotic spray (burroughs wellcome co., research triangle park, n.c.) is a dry spray containing 200,000 units aerosporin (polymyxin b sulfate) and 10,000 units bacitracin zinc, along with a propellant. each 1-second spray delivers approximately 2300 units of polymyxin b sulfate and 115 units of bacitracin zinc. this study was designed to evaluate the efficacy of polysporin spray against various clinical isolates. blood agar plates were inoculated with a pure culture of eac ... | 1991 | 2050717 |
| properties of a deep proteus r mutant isolated from clinical material. | some biological features of a deep p. mirabilis 17301 r mutant isolated from the urine of a patient with chronic uti were studied and compared with similar features of p. mirabilis s forms and five induced proteus r mutants of different chemotypes. there were no differences in lethal toxicity and adhesion to human uroepithelial cells. of all the r mutants tested, two of them, 17301 and r4, exhibited strong cell-bound hemolytic activity. the p. mirabilis r 17301 was characterized as the most inva ... | 1991 | 2054167 |
| [proteus syndrome]. | proteus syndrome is a rare congenital disorder in which the major clinical manifestations are skeletal deformities and hamartomatous tumors. the case of a 42-year-old woman with right hemihypertrophy, macrodactyly of the right hallux, extreme kyphoscoliosis and bilateral plantar connective tissue naevi is reported. proteus syndrome is reviewed with reference to this patient. | 1991 | 2055768 |
| antibacterial activity of crotalid venoms against oral snake flora and other clinical bacteria. | despite heavy oral and fang contamination of crotalid species with a wide variety of potentially pathogenic bacteria, crotalid envenomation is associated with a low incidence of bacterial infection. minimal inhibitory and bactericidal concentrations of venoms from three crotalid species were determined against six aerobic and eight anaerobic reference and oral crotalid microorganisms. all anaerobic isolates were resistant to greater than 20,480 micrograms/ml, whereas variable activity (range, 5- ... | 1991 | 2056205 |
| [postoperative infections in systemic immunocompromising diseases. a study of 6 patients]. | advances of therapeutic strategies in the management of critically ill patients have resulted in an increased life expectancy and more frequent presentations to ophthalmic surgeons. six patients with postoperative endophthalmitis after elective intraocular surgery suffering from sharp-syndrome, metastasizing antrum carcinoma, granulomatous vasculitis and immunosuppressive therapy, agranulocytosis, silico-tuberculosis and chronic lymphatic leukemia revealed traditionally pathogenic agents (proteu ... | 1991 | 2056737 |
| craniofacial characteristics of proteus syndrome: two modes of abnormal growth. | the dysmorphic growth patterns of the craniofacial skeleton are summarized in five patients with the proteus syndrome. two different modes of abnormal growth are present. one mode involves focal overgrowth of membrane bones, producing multiple hyperostoses which result in progressive craniofacial disfigurement and asymmetry. the second mode involves overgrowth of cartilage in the condyle, resulting in dentofacial asymmetry. the phenotype of the craniofacial skeleton results from both processes. ... | 1991 | 2057486 |
| [penoscrotal gangrene: our series of cases]. | ten cases of penoscrotal gangrene seen in our department over the last 8 years are presented. in 80% of patients causative factors of the gangrenous process were demonstrated and were equally distributed between urology and colorectal pathologies. the most commonly associated pathology was diabetes mellitus affecting up to 50% of our patients. two or more germs were isolated from the necrotic-purulent material for cultures, mainly e. coli (90%) and proteus mirabilis (50%) as aerobic organisms, a ... | 1991 | 2058440 |
| groin wound infection after arterial surgery. | fifty-six patients, 30 with superficial and 19 with deep groin wound infections, and seven with lymph fistulae with positive cultures within 30 days of arterial surgery, were identified after 661 operations (873 groins at risk) between september 1984 and august 1988. the commonest infecting organisms were staphylococcus aureus, pseudomonas aeruginosa and proteus spp. in 33 patients the infection settled completely after treatment with culture specific antibiotics. these were given intravenously ... | 1991 | 2059820 |
| urolithiasis in children. | a retrospective study of childhood urolithiasis was performed from july 1978 to december 1989 in the national taiwan university hospital. during the eleven years, fourteen patients aged from 1 to 16 years were enrolled. the male to female ratio was 10:4, but no sex predilection was found in seven children with bladder stone(s) (m:f = 4:3), hematuria and pyuria were the commonest symptoms and signs. bladder stone was the most frequently encountered stone while renal stone was the second. the unde ... | 1991 | 2063681 |
| evidence for n----o acetyl migration as the mechanism for o acetylation of peptidoglycan in proteus mirabilis. | o-acetylated peptidoglycan was purified from proteus mirabilis grown in the presence of specifically radiolabelled glucosamine derivatives, and the migration of the radiolabel was monitored. mild-base hydrolysis of the isolated peptidoglycan (to release ester-linked acetate) from cells grown in the presence of 40 microm [acetyl-3h]n-acetyl-d-glucosamine resulted in the release of [3h]acetate, as detected by high-pressure liquid chromatography. the inclusion of either acetate, pyruvate, or acetyl ... | 1991 | 2066331 |
| [complex treatment of acute purulent-inflammatory diseases of the fingers and hand using decamethoxine]. | | 1991 | 2067227 |
| efficacy and safety of aztreonam in the treatment of patients with renal failure. | the efficacy and safety of aztreonam for treatment of gram-negative bacterial infections in patients with renal failure were evaluated in an open study. thirty-nine patients (22-82 years old) with renal failure (chronic, 25; acute, 14) were treated for 40 severe gram-negative bacterial infections. all 41 gram-negative pathogens isolated were sensitive to aztreonam; the pathogens included escherichia coli (12), pseudomonas aeruginosa (8), klebsiella species (7), proteus species (7), enterobacter ... | 1991 | 2068477 |
| xanthogranulomatous pyelonephritis with nephrocutaneous fistula at the knee. | | 1991 | 2070215 |
| efficacy and tolerance of cefodizime in the treatment of acute pyelonephritis. | the efficacy and tolerance of cefodizime in the treatment of acute pyelonephritis were evaluated in an open, international, multicentre study. in total, 128 patients were treated with 1 g cefodizime bd iv or im for a mean of 8.3 days. underlying urinary tract abnormalities were present in 35% of cases. the most frequently isolated bacteria were escherichia coli (79/97 evaluable cases) and proteus mirabilis (8/97 evaluable cases). the overall clinical and bacteriological success rate was 89.7% (8 ... | 1990 | 2074245 |
| the in-vitro activity of cefodizime: a review. | for enterobacteriaceae, mic50s and mic90s of cefodizime (mg/l), respectively, were as follows, for naturally non-beta-lactamase-producing species: escherichia coli 0.12 and 0.5, salmonella spp. and shigella spp. 0.25 and 0.5, proteus mirabilis 0.016 and 0.03; for chromosomal penicillinase-producing species. klebsiella spp. 0.25 and 64, and for chromosomal cephalosporinase-producing species. enterobacter cloacae 1 and 64, citrobacter freundii 1 and 128, serratia marcescens 2 and 8: indole-positiv ... | 1990 | 2074248 |
| [studies on the sub-mic of beta-lactam antibiotics--bactericidal activity in compromised host's serum]. | bactericidal activity in compromised host's serum i.e. patients with cancer, the elderly, diabetes, was stronger than that in normal serum against proteus mirabilis (p. mirabilis) but was weaker against klebsiella pneumoniae (k. pneumoniae). against escherichia coli (e. coli), bactericidal activity on serum of patients with cancer was weaker in the following order, that in elderly serum, that in diabetic serum. against proteus vulgaris (p. vulgaris), bactericidal activity in elderly serum was si ... | 1990 | 2074367 |
| [prospects of using controlled-action lactoglobulins in the treatment of acute intestinal infections and dysbacteriosis in infants]. | the author summarizes the results of the preclinical study and clinical trial of the new biological drug lactoglobulin having an +anti-coli-proteus action. shows that the drug holds promise in the treatment of infants with acute intestinal infections and dysbacteriosis as well as in the enrichment of lactic mixtures used for artificial feeding of premature children and babies referred to the risk group. | 1990 | 2075046 |
| vaginal hysterectomy: cefuroxime, metronidazole or both? | a randomized double-blind prospective study on the efficacy of single-dose antibiotic prophylaxis compared cefuroxime versus metronidazole versus the combination of both agents in vaginal hysterectomy. overall antibiotic prophylaxis was effective in abscess prevention (one abscess in 68 patients). in the metronidazole group a significantly higher grade of morbidity was observed: febrile morbidity 41% versus 4% in the two other groups; bacteriuria 73% versus 17% in the cefuroxime group, versus 13 ... | 1990 | 2075080 |
| [a new method of sterilization of donor eyes]. | microbiologic examinations of 200 pairs of donor eyes have revealed pseudomonas aeruginosa, escherichia coli, staphylococcus aureus, and proteus infection of 124 pairs of eyes (62 percent). sensitivities of the isolated microorganisms to various antibacterial drugs was examined. gentamicin and chlorhexidine proved to be the most effective in respect of the microorganisms isolated from cadaveric eyes. these results enabled the authors suggest a new method for donor eyes sterilization, consisting ... | 1990 | 2075647 |
| otogenic intracranial abscesses. | the commonest cause of the intracranial abscesses collected prospectively during the last two years was chronic middle ear infection (73%). the diagnosis was based on the clinical history, otological investigations, contrast enhanced computerized tomography and surgical findings. the clinical presentation was characterized by chronic otitis with an exacerbation of otorrhea, otalgia or pain in the temporal region or headache with high fever, vomiting and nausea. a review of our 14 patients with o ... | 1990 | 2077851 |
| [xanthogranulomatous pyelonephritis in infancy and childhood. report of two cases]. | we are reporting 2 cases of xanthogranulomatous pyelonephritis in boys of 7 and 2 year-old. the inflammatory lesion had extended to perirenal tissues and appeared as a lumbar abscess in case 1. the kidneys affected were diffusely compromised by the lesion. both cases showed proteus mirabilis after microbiologic cultures. definitive diagnosis was done by pathology examination. nephrectomy was curative. | 1990 | 2078000 |
| screening for delayed-hypersensitivity in italian children: multicentric study by multitest skin testing. | the multitest skin test allows the simultaneous intradermal application of seven standardized recall antigens in a reproducible manner. response reading is based on a scoring system that distinguishes between normal and diminished delayed hypersensitivity (dh). to determine incidence and size of dh responses for each antigen in relation to age and sex in healthy italian children, a multicentric study was performed on a representative paediatric population of 491 subjects (285 males and 296 femal ... | 1990 | 2079075 |
| [clinical experiences with cefixime in the treatment of bacterial infections of the lower respiratory tract]. | in a prospective, open clinical trial 21 patients suffering from lower respiratory tract infections were treated with the new oral cephalosporin cefixime. the antibiotic was given at a dosage of 200 mg b. i. d. for seven to eleven days. seventeen of 18 evaluable patients were cured or distinctly improved at the end of therapy as well as two days after the end of treatment. clinical results correlated well with the results of the lung function tests, especially with the significant decrease of re ... | 1990 | 2079369 |
| [cefixime in urinary tract infections. (specific studies and literature review)]. | cefixime, a new oral cephalosporin, is more active against enterobacteriaceae than the conventional oral cephalosporins. about 20% of the drug is excreted by the kidneys as active drug. therefore, the treatment of urinary tract infection (uti) by cefixime may be a good alternative. in two smaller uncontrolled and four larger, controlled (amoxicillin, co-trimoxazole) "western" studies as well as in eight japanese studies the good efficacy of cefixime in uncomplicated uti could be demonstrated. be ... | 1990 | 2079373 |
| [effectiveness and tolerance of cefixime in the treatment of acute pyelonephritis]. | in a prospective, open clinical study, 50 urological patients with acute pyelonephritis were treated with the oral cephalosporin cefixime. the medication (2 x 200 mg/day) was given for seven to ten days. clinical, bacteriological as well as hematological examinations were carried out prior to, during and immediately after therapy. a late check-up was performed five to nine days after the end of therapy. 46 of the 50 cases were evaluable for efficacy, and all 50 patients were included in safety e ... | 1990 | 2079374 |
| [antibacterial activity and beta-lactamase stability of eleven oral cephalosporins]. | oral cephalosporins (cefixime, cefdinir, cefetamet, ceftibuten, cefpodoxime, loracarbef, cefprozil, cefuroxime, cefaclor, cefadroxil and bay 3522) were compared by their antibacterial profile including stability against new beta-lactamases. both activity and antibacterial spectrum of compounds structurally related to third generation parenteral cephalosporins (of the oximino class) were superior to established compounds. activity against staphylococci was found to be highest for cefdinir, cefpro ... | 1990 | 2079378 |
| trimethoprim, sulphamethoxazole, bacterial adhesion and polymorphonuclear leucocyte function. | culturing escherichia coli, proteus mirabilis and klebsiella pneumoniae in the presence of subinhibitory concentrations (1/4 mic) of trimethoprim, sulphamethoxazole or their combination, resulted in reduced adherence of all the above strains. the number of phagocytosed bacteria pre-exposed to subinhibitory concentrations of the above antibiotics was not significantly changed, but a significant increase of bactericidal activity of the polymorphonuclear leucocytes was observed. furthermore, filtra ... | 1990 | 2081720 |
| phallus-inflammation of ganders: clinical observations and comparative bacteriological examinations of healthy and altered organs. | the examination of acute or chronically altered phallus-tissues of ganders revealed microorganisms belonging to the genera mycoplasma, bacteroides, clostridium, streptococcus, micrococcus, staphylococcus, lactobacillus, corynebacterium, escherichia, campylobacter, proteus, pseudomonas and candida and to the family pasteurellaceae, isolated in different frequencies. bacteriologic examinations of the phallus-tissues and cloacal mucous membranes of healthy juvenile ganders showed microorganisms of ... | 1990 | 2082630 |
| infection of a renal cyst, a rare complication of bronchopneumonia. | the authors report a rare case of abscess developed in a solitary renal cyst and observed just after the resolution of a bronchopneumonia. the modern imaging techniques, sonography and computed tomography, permitted an exact diagnosis, and subsequent surgical treatment brought to a complete recovery. | 1990 | 2082744 |
| clinical evaluation of the imipenem/cilastatin combination in the therapy of severe infections in patients with malignant diseases. | thirty hospitalized patients (23 men and 7 women), aged 42 to 78 years, with impaired host defences for malignant underlying diseases and affected by life-threatening infections, were treated with the imipenem/cilastatin combination at a dosage ranging between 2 and 4 g daily i.v. at 8 or 12 h intervals. the average length of therapy was 9.6 +/- 2.09 days. the isolated organisms were as follows: pseudomonas aeruginosa [12], escherichia coli [10], klebsiella pneumoniae [5], proteus mirabilis [3], ... | 1990 | 2086164 |
| antimicrobial activity and beta-lactamase stability of bmy-28232, parent compound of an oral cephalosporin. | bmy-28232, an aminothiazolyl imino methoxy cephalosporin which is available as an orally absorbed acetoxyethyl ester, inhibited strains of methicillin-susceptible staphylococcus aureus, hemolytic streptococci, streptococcus pneumoniae, escherichia coli, klebsiella species, and many strains of proteus and providencia stuartii at concentrations less than 1 microgram/ml, including isolates resistant to cephalexin and cefaclor. it had activity similar to that of cefixime, but was more active against ... | 1990 | 2086221 |
| [susceptibilities of clinical bacterial isolates to antimicrobial agents. a study mainly focused on imipenem. research group for testing imipenem susceptibility on clinical isolates]. | we investigated susceptibilities of clinical bacterial isolates to imipenem (ipm) and other antimicrobial agents at 459 hospital laboratories throughout japan from september to december of 1988. in this study, identification and susceptibility testing were performed at each hospital laboratory and the tests were carried out according to the 1-dilution or 3-dilution disc technique in which susceptibilities are classified into 4 grades: , ++, + and -. ipm had significantly high activity against st ... | 1990 | 2086814 |
| [immunoreactivity in suppurative keratitis]. | immunologic analysis of blood serum of 40 patients with purulent keratitis has shown disturbances in t- and b-systems of immunity, especially in moderate and severe degrees of the disease. this dictates a necessity of further studies in this direction by using immunocorrective therapy. | 1990 | 2092257 |
| nucleotide sequences of 16s rrna from ten serratia species. | comparison of 16s ribosomal ribonucleic acid (rrna) sequences has emerged as a powerful tool for bacterial phylogeny. however, earlier studies often only included one or a few species per genus, and it is not sure whether the rrna sequences could discriminate closely related species. the genus serratia is composed of ten species, some being up to 60% related by dna hybridization. the reverse transcriptase/primer extension method was used to determine 1,492 to 1,509 nucleotides in each of ten ser ... | 1990 | 2092365 |
| [ciprofloxacin in the treatment of infections in oncology patients]. | treatment of infectious complications with ciprofloxacin in 65 patients provided good and satisfactory results in 67.7 and 20.0 per cent of the cases, respectively. the drug was efficient in sepsis, urogenital infections, respiratory infections and postoperative purulent complications. ciprofloxacin showed a broad antibacterial spectrum. 96.3 per cent of the isolates belonging to aerobic organisms causing purulent inflammatory processes, including those with high antibiotic resistance levels, su ... | 1990 | 2092640 |
| enhancement of in-vitro activity of ofloxacin and gentamicin by rat serum. | normal rat serum shows antibacterial activity because of the presence of endogenous substances. the aim of this research was to study some aspects of the interaction between this biological fluid and some antibiotics, in order to demonstrate possible synergistic activity. serum is able to lower the minimum inhibitory concentration of gentamicin and ofloxacin against some gram-negative microorganisms. this can be explained by the presence of lysozyme, antibodies, beta-lysin and other complementar ... | 1990 | 2093107 |
| investigations of the activity by contact of miconazole sulfosalicylate. | the in-vitro antimicrobial activity of miconazole sulfosalicylate (m.ssa) has been investigated on mycetes (candida albicans, cryptococcus neoformans, aspergillus niger, trichophyton mentagrophytes), gram-positive bacteria (staphylococcus aureus, streptococcus faecalis) and gram-negative bacteria (escherichia coli, pseudomonas aeruginosa, serratia marcescens and proteus vulgaris) in comparison with miconazole nitrate (m.nit). the results showed m.ssa has a greater activity than m.nit, particular ... | 1990 | 2093108 |
| proteus syndrome. | | 1990 | 2093683 |
| in vitro bacterial penetration of coronally unsealed endodontically treated teeth. | forty-five root canals were cleaned, shaped, and then obturated with gutta-percha and root canal sealer, using a lateral condensation technique. the coronal portions of the root filling materials were placed in contact with staphylococcus epidermidis and proteus vulgaris. the number of days required for these bacteria to penetrate the entire root canals was determined. over 50% of the root canals were completely contaminated after 19-day exposure to s. epidermidis. fifty percent of the root cana ... | 1990 | 2094758 |
| biosynthesis of biotin-vitamers by family enterobacteriaceae. | the biosynthesis of biotin-vitamers from various carbon sources by the members of the enterobacteriaceae as one of the groups of intestinal bacteria was investigated. the biotin-vitamers synthesized in each case included one or more of dethiobiotin (main product), 7-keto-8-aminopelargonic acid, and biotin. true biotin was shown to be synthesized under aerobic conditions but not under anaerobic conditions by each of several strains belonging to one of the genera, erwinia, escherichia, proteus, an ... | 1990 | 2097319 |
| [in vitro evaluation of antibacterial activity of the original oxime type of beta-lactam antibiotics with the 4-aminobenzensulfonamide group]. | four newly prepared beta-lactam antibiotics of the oxime type with a 4-aminobenzensulphonamidogroup, synthetized at the research institute for pharmacy and biochemistry, prague, were subjected to an evaluation of antibacterial efficacy in vitro. the evaluation was carried out by determining the minimal inhibitory concentration (mic) in 47 clinical strains and 6 standard strains (staphylococcus aureus, streptococcus pyogenes and facecalis, e. coli, enterobacter and proteus spec., pseudomonas aeru ... | 1990 | 2098201 |
| [in vitro antibacterial activity of new oxime type of beta-lactam antibiotics]. | the antibacterial efficacy of two novel beta-lactam antibiotics of the oxime type, vufb 16265 and 16272, was evaluated by determining the minimal inhibitory concentration (mic) in 47 clinical strains and 6 standard strains (staphylococcus aureus, streptococcus pyogenes and faecalis, e. coli, enterobacter and proteus spec., pseudomonas aeruginosa), which were the most frequent causes of infectious complications. the results were compared with the mic of cefalexin, cefoxitin, cefazolin, cefsulodin ... | 1990 | 2098202 |
| [the phospholipases of proteus mirabilis]. | the method of screening proteus for phospholipase activity has been worked out. the study of isolated clones of the same strain, used as an example, has revealed that clones differing in their phospholipase activity also differ in virulence and in some parameters of interaction in the host-parasite system. p. mirabilis phospholipases are supposed to be of importance as one of the factors contributing to the invasive properties of these microorganisms at the stage of overcoming the epithelial cel ... | 1990 | 2099068 |
| effect of extracorporeal shock wave lithotripsy on bacterial viability. relationship to the treatment of struvite stones. | the aim of this study was to determine whether extracorporeal shock wave lithotripsy (eswl) affected the viability of the infecting bacteria within a simulated struvite stone matrix. a strain, proteus mirabilis 28cii, was prepared in three forms: (1) suspended in saline and urine, (2) artificially encapsulated by suspending in agar beads and (3) artificially encapsulated and mineralised by suspending in agar beads with calcium carbonate crystals. the preparations were placed in capped vials part ... | 1990 | 2100420 |
| bacterial agents associated with bronchopulmonary disorders in eastern nigeria. | altogether 16,539 sputum specimens were examined microbiologically from 1980 to 1984. out of these 12,588 were screened by ziehl-neelsen's staining technique and 782 were (6.3%) found afb-positive. age and sex distributions of the afb-positive individuals were statistically significant (at 0.05), incidence being most prevalent among those 20 years and above (90.2%) and among males (61.2%). from other specimens cultured, non-afb organisms were isolated at the following frequencies: coliform-like ... | 1990 | 2101201 |
| [etiopathogenesis of the inflammation process and the incidence of urinary tract infections]. | etiopathogenesis of inflammatory processes of the urinary tract, mainly of obstructive uropathy and chronic pyelonephritis, is reviewed. the most frequent cause of obstruction is renal calculosis; in the pathogenesis of chronic pyelonephritis the following factors are of great importance: renal and urethral anomalies, renal stones, pregnancy, bladder instrumentation as catheterisation, etc. we analyzed 2101 random by selected hospital patients and found significant bacteriuria in 740 (35 p.c.) o ... | 1990 | 2102560 |
| [sepsis at an internal medicine department]. | 185 cases of bacteremia admitted at the internal medicine department of "c.s. virgen de la arrixaga" in murcia from 1977 to 1986, were studied retrospectively. the common infection was significantly associated to staphylococcus aureus, streptococcus pneumoniae, streptococcus a group and neisseria meningitidis and the nosocomial infection was associated to klebsiella pneumoniae, serratia marcescens y pseudomonas aeruginosa, staphylococcus epidermidis and enterobacter. we did not find significant ... | 1990 | 2103194 |
| [the etiology and resistance of extrahospital urinary infections]. | | 1990 | 2103821 |
| synthesis and structure-activity relationships of new 7-[3-(fluoromethyl)piperazinyl]- and -(fluorohomopiperazinyl)quinolone antibacterials. | some novel 6-fluoro-7-substituted-1,4-dihydro-4-oxoquinoline-3-carboxylic acids have been prepared. at the n-1 position "standard" substitution was employed with the ethyl, cyclopropyl, and p-fluorophenyl groups being used. at c-7 the introduction of some novel piperazines was made. most notably, 2-(fluoromethyl)piperazine (10) and hexahydro-6-fluoro-1h-1,4-diazepine (16, fluorohomopiperazine) at the quinolone c-7 position produced products with similar in vitro antibacterial activity as the cip ... | 1990 | 2104934 |
| new screening test to determine the acceptability of 0.45-micron membrane filters for analysis of water. | during routine membrane filter (mf) quality control testing, irregularities such as partial or complete inhibition of microbial growth at grid lines, abnormal spreading of colonies, growth in or along the grid lines, nonwetting areas, poor colony sheen and metallic sheen on the mf surface with mendo agar, brittleness, decreased recovery, and severe wrinkling were observed with several lots of filters. to study these effects and to develop a more sensitive screening test for mf quality, we compar ... | 1990 | 2106827 |