Publications

TitleAbstractYear(sorted ascending)
Filter
PMID
Filter
synthesis and antimicrobial activity of highly functionalised novel β-lactam grafted spiropyrrolidines and pyrrolizidines.a facile and one-pot synthesis of a series of novel spiropyrrolidines/pyrrolizidines with β-lactam substituent has been accomplished through 1,3-dipolar cycloaddition reaction of alkenyl esters derived from β-lactam aldehyde as dipolarophile with the dipole azomethine ylide derived from 1,2- and 1,3-diketones and secondary amino acids. the synthesized compounds were evaluated for antimicrobial activities and found to exhibit relatively good antibacterial activity at lower concentration against f ...201021177001
asymptomatic bacteriuria among hiv positive pregnant women.the prognostic significance of asymptomatic bacteriuria resides in the observation that the prevalence is, relatively, high in persons with certain medical conditions, such as diabetes mellitus and pregnancy. this prevalence might, even, be higher in patients with human immunodeficiency virus infection. hence, this study set out to determine the prevalence of asymptomatic bacteriuria among symptom free and newly enrolled hiv infected pregnant women attending pmtct unit of antiretroviral clinic o ...201021178431
effect of neem extract against the bacteria isolated from marine fish.marine ornamental fishes are exceedingly valuable due to their high demand in domestic and international markets. there is a growing global interest to rear the fishes in captivity. but problem due to bacteria and fungi are the major hitch in captive condition. since, the use of antibiotics is banned, an attempt was made to ascertain in vitro assay of the neem leaves extract against the bacterial pathogens isolated from infected fishes. bacterial strains isolated from infected regions of the clo ...201021186711
the salmonella genomic island 1 is specifically mobilized in trans by the inca/c multidrug resistance plasmid family.the salmonella genomic island 1 (sgi1) is a salmonella enterica-derived integrative mobilizable element (ime) containing various complex multiple resistance integrons identified in several s. enterica serovars and in proteus mirabilis. previous studies have shown that sgi1 transfers horizontally by in trans mobilization in the presence of the inca/c conjugative helper plasmid pr55.201021187963
thyroid pathology in pten-hamartoma tumor syndrome: characteristic findings of a distinct entity.phosphatase and tensin homolog deleted on chromosome ten (pten)-hamartoma tumor syndrome (phts) is a complex disorder caused by germline inactivating mutations of the pten tumor suppressor gene. phts includes cowden syndrome (cs), bannayan-riley-ruvalcaba syndrome (brrs), and proteus-like syndromes. affected individuals develop both benign and malignant tumors in a variety of tissues, including the thyroid. this study is to better characterize and describe the thyroid pathology within the differ ...201021190448
synthesis and evaluation of a class of new coumarin triazole derivatives as potential antimicrobial agents.a series of new coumarin-based 1,2,4-triazole derivatives were designed, synthesized and evaluated for their antimicrobial activities in vitro against four gram-positive bacteria (staphylococcus aureus, mrsa, bacillus subtilis and micrococcus luteus), four gram-negative bacteria (escherichia coli, proteus vulgaris, salmonella typhi and shigella dysenteriae) as well as three fungi (candida albicans, saccharomyces cerevisiae and aspergillus fumigatus) by two-fold serial dilution technique. the bio ...201021215620
characterization of the enterobacteriaceae community that developed during storage of minced beef under aerobic or modified atmosphere packaging conditions.the whole cell protein and macrorestriction analysis of dna of enterobacteriaceae isolates recovered from minced beef stored at 0, 5, 10 and 15 °c aerobically and under modified atmosphere packaging consisting of 40% co(2)-30% o(2)-30% n(2) in the presence (map+) and absence (map-) of oregano essential oil were studied. sodium dodecyl sulphate polyacrylamide gel electrophoresis (sds-page) profiles obtained from whole cell protein analysis of the enterobacteriaceae isolates revealed seven groups. ...201021216482
antimicrobial activity of α-(2-hydroxy-2-methylpropyl)-ω-(2-hydroxy-3-methylbut-2-en-1-yl) polymethylene from caesalpinia bonducella (l.) flem.the compound, α-(2-hydroxy-2-methylpropyl)-ω-(2-hydroxy-3-methylbut-2-en-1-yl)polymethylene, isolated from ethyl acetate leaf extract of caesalpinia bonducella (l.) flem. was evaluated for antimicrobial activity against clinical isolates, proteus vulgaris, pseudomonas aeruginosa, klebsiella sp., staphylococcus citrus, staphylococcus aureus, escherichia coli, candida albicans and rhodotorula sp. using agar diffusion method. the compound exerted inhibitory zone at all concentrations and revealed t ...201021218063
the prevalence and bacteriology of asymptomatic bacteriuria among antenatal patients in nnamdi azikiwe university teaching hospital nnewi; south eastern nigeria.background: urinary tract infection in pregnancy leads to poor pregnancy outcome. diagnosis and treatment of asymptomatic bacteriuria markedly improves pregnancy outcome as well as reduce the incidence of acute pyelonephritis. objective: to determine the prevalence and bacteriology of asymptomatic bacteriuria among antenatal patients in our centre, and to know if routine screening will be justifiable. materials and methods: this was a prospective study carried out between april and august 2008. ...201021220855
electron transfer from proteus vulgaris to a covalently assembled, single walled carbon nanotube electrode functionalised with osmium bipyridine complex: application to a whole cell biosensor.we report the fabrication and use of electrodes constructed from single walled carbon nanotubes (swcnts) chemically assembled on a carbon surface and functionalised with an osmium(ii) bipyridine complex (osbpy). the ability of the electrodes to transduce biologically generated currents from proteus vulgaris has been established. our investigations show that there are two contributions to the current: one from electroactive species secreted into solution and another from cell redox sites. the mod ...201021067910
salmonella genomic islands and antibiotic resistance in salmonella enterica.antibiotic resistance in several salmonella enterica serovars that cause gastrointestinal disease in humans is due to a set of related genomic islands carrying a class 1 integron, which carries the resistance genes. salmonella genomic island 1 (sgi1), the first island of this type, was found in s. enterica serovar typhimurium dt104 isolates, which are resistant to ampicillin, chloramphenicol, florfenicol, streptomycin, spectinomycin, sulfonamides and tetracycline. several salmonella serovars and ...201021073312
high levels of multidrug resistance in clinical isolates of gram-negative pathogens from nigeria.in nigeria, quinolones and β-lactam antibiotics are widely used to treat bacterial infections. this study aimed to identify the prevalence of resistance to these drugs and to determine the mechanisms of resistance to these agents. in total, 134 non-duplicate, gram-negative enteric isolates of 13 species from different hospitals were investigated for susceptibility to a panel of antibiotics, carriage of plasmid-mediated quinolone and β-lactam resistance genes, production of extended-spectrum β-la ...201021074376
pan-susceptible proteus mirabilis septicemia in a patient multicolonized by pan-resistant bacteria. 201021193275
screening of bloodborne pathogens and antimicrobial susceptibility testing among cancer patients.to screen bloodborne pathogens and test for antimicrobial susceptibility among patients with different types of cancer.201021198306
bacteremia in a multilevel geriatric hospital.bloodstream infection (bsi) is a major cause of morbidity and mortality in hospitals. bacteremia in the elderly remains a diagnostic as well as a therapeutic challenge to the clinician.201021333922
akara ogbomoso: microbiological examination and identification of hazards and critical control points.akara ogbomoso was examined toward the establishment of hazard analysis and critical control point (haccp). the akara was produced in residential buildings with the attendant consequence of contamination. there was ample growth of aerobes, coliforms, staphylococci, shigella and yeast/mold from the samples, water and cowpea pastes. microbial contaminations occur through the processing, which can be corrected through education by adopting good hygienic and manufacturing practices. the critical con ...201021339157
plasmid-mediated quinolone resistance in expanded spectrum beta lactamase producing enterobacteriaceae in morocco.although independently acquired, plasmid-mediated quinolone resistance appears to be linked with extended-spectrum or ampc-type beta-lactamases. since no data are available in african countries, the prevalence of qnr genes at the university hospital ibn rochd, casablanca, morocco, was investigated.201021252459
assessment of effectiveness and safety of ibicella lutea extract in the control of experimental proteus mirabilis urinary tract infection.proteus mirabilis is an important cause of complicated urinary tract infections (uti). like many other microorganisms, p. mirabilis has acquired resistance to many antibiotics. due to the serious effects associated with uropathogenic p. mirabilis and the problems related to the use of antibiotics, alternative strategies for its control must be developed. previously, we studied the effect of ibicella lutea extract, a south american indigenous plant, on in vitro uropathogenicity of p. mirabilis. w ...201021252462
microbial evaluation and public health implications of urine as alternative therapy in clinical pediatric cases: health implication of urine therapy.cultural means of pediatric treatment during ill health is a mainstay in africa, and though urine has been known to contain enteric pathogens, urine therapy is still culturally applicable in some health conditions and also advocated as alternative therapy. the study therefore, is to evaluate the microbial contents and safety of urine.201021293739
a case of disproportionate macrodactyly or a mild form of proteus syndrome? an interesting case.we present a 20-year-old malay male whom we believe has proteus syndrome, a rare congenital disorder of asymmetrical overgrowth of body tissues. there are fewer than 100 confirmed cases reported worldwide thus the clinical presentation and histopathological findings are of significance. our patient presented with an overgrown right small finger and subcutaneous purplish pigmentation over his left upper arm and chest since birth. his small finger gradually increased in size. he had no abnormaliti ...201021400985
prevalence of pseudomonas aeruginosa in post-operative wound infection in a referral hospital in haryana, india.the objective of our study was to determine the prevalence of pseudomonas aeruginosa in the isolates of postoperative wound and its susceptibility pattern to commonly used antibiotics.201021346900
[immunovac-vp-4 for prevention of acute respiratory diseases in children's communities].assessment of prophylactic effect of immunovac-vp-4 against acute respiratory diseases (ards) in collectives of children.201021381375
role of bacteria isolates in the spoilage of fermented african oil bean seed ugba.study was carried out to determine the spoilage association of traditionally fermented ugba, product of african oil bean seed. samples were collected from three markets within enugu metropolis in eastern nigeria. microbial population of ugba was isolated, characterized and identified. effect of time on product quality, total viable cell count and individual growth pattern of isolates was evaluated. microorganisms isolated were proteus sp., klebsiella sp., staphylococcus epidermidis, e. coli, bac ...201021848074
studies of antimicrobial activities of some 4-thiazolidinone fused pyrimidines, [1,5]-benzodiazepines and their oxygen substituted hydroxylamine derivatives.thiazolidin-4-one fused pyrimidines, [1,5]-benzodiazepines and their oxygen substituted hydroxylamine derivatives have been screened for antibacterial, antifungal and antimalarial activity. bacillus subtilis, escherichia coli, proteus mirabilis and salmonella typhi were used for antibacterial screening. aspergillus fumigatus and candida albicans were used for antifungal screening and plasmodium species were used for antimalarial screening. the antibacterial and antifungal activities are expresse ...201021694993
antibiotic susceptibility pattern of urinary tract pathogens in ibadan, nigeria.urinary tract infections (uti) affect all age groups and occur in both hospitalized and non-hospitalized individuals and have serious impact on the socioeconomic life of the individual and the society, and also account for a large proportion of antibacterial drug consumption. treatment failure has been attributed to increasing resistance to common antibiotics, but there is paucity of data from this part of nigeria. this prospective study was carried out to determine the prevalence and antibiotic ...201021416786
[antimicrobial susceptibility of clinical isolates of aerobic gram-negative bacteria in 2006].we determined mics of antibacterial agents against 1280 clinical strains of aerobic gram-negative bacteria (19 genus or species) isolated at 16 japanese facilities in 2006. mics were determined using mostly broth microdilution method and antibacterial activity was assessed. strains producing extended-spectrum beta-lactamases (esbl) accounted for 3.7% of escherichia coli, 2.7% of klebsiella spp., and 11.4% of proteus spp. notably, 18.8% of proteus mirabilis was found to produce esbl higher than 1 ...201021425597
syndromes with focal overgrowth in infancy: diagnostic approach and surgical treatment.abstract syndromes with focal overgrowth are sporadic diseases and comprise proteus syndrome and congenital lipomatous overgrowth, vascular malformations, and epidermal naevi (clove) syndrome, and isolated hemihyperplasia. we describe 3 children classified according to standard criteria with dysregulated growth of various tissues that was excised, together with excess toes, and tumours. correct classification facilitates diagnosis and operations. interdisciplinary treatment and follow-up are rec ...201021446802
lactobacillus fermentum isolated from human colonic mucosal biopsy inhibits the growth and adhesion of enteric and foodborne pathogens.a number of lactobacillus species are used as probiotic strains in order to benefit health. we have isolated l. fermentum from human colonic mucosal biopsy samples that possess antimicrobial activities against entroinvasive and foodborne pathogens such as escherichia coli, salmonella paratyphi a, shigella sonnei, staphylococcus aureus, enterococcus faecalis, proteus mirabilis, pseudomonas aeruginosa, and vibrio sp. in addition to lactic acid, l. fermentum secretes antimicrobial proteinacious com ...201021535608
extended-spectrum beta-lactamase orthopedic wound infections in nigeria.extended-spectrum beta-lactamase (esbl)-producing gram-negative bacteria are emerging and impacting significantly on the management of patients and hospital costs. besides, they are not being routinely sought after in diagnostic laboratories thus contributing to treatment failure.201121887050
evaluation of abelmoschus moschatus extracts for antioxidant, free radical scavenging, antimicrobial and antiproliferative activities using in vitro assays.abelmoschus moschatus medik. leaves and seeds are considered as valuable traditional medicine. the aromatic seeds of this plant are aphrodisiac, ophthalmic, cardio tonic, antispasmodic and used in the treatment of intestinal complaints and check queasiness. to give a scientific basis for traditional usage of this medicinal plant, the seed and leaf extracts were evaluated for their antioxidant, free radical scavenging, antimicrobial and antiproliferative activities.201121849051
a self-loading microfluidic device for determining the minimum inhibitory concentration of antibiotics.this article describes a portable microfluidic technology for determining the minimum inhibitory concentration (mic) of antibiotics against bacteria. the microfluidic platform consists of a set of chambers molded in poly(dimethylsiloxane) (pdms) that are preloaded with antibiotic, dried, and reversibly sealed to a second layer of pdms containing channels that connect the chambers. the assembled device is degassed via vacuum prior to its use, and the absorption of gas by pdms provides the mechani ...201122193301
asymmetric, disproportionate craniofacial hyperostoses of mosaic pattern in a patient not meeting proteus syndrome criteria.a 34-year-old patient with asymmetric hyperostosis of the craniofacial skeleton much more pronounced on the right side is presented. a long-term follow-up of 16 years showed progression of overgrowth even after skeletal maturity and despite repeated surgical corrections focusing on regional reduction of the hyperostoses. clinical situation during infancy, adolescence, and adulthood is documented. although the craniofacial hyperostosis in the patient was indicative of the proteus syndrome, the ap ...201122134251
antibacterial activity of water-soluble extract from pine needles of cedrus deodara.the antibacterial activity of water-soluble extract from pine needles of cedrus deodara (wec) was evaluated on five food-borne bacteria, and its related mechanism was investigated by transmission electron microscope. in vitro antibacterial assay showed that wec possesses a remarkable antibacterial activity against tested food-borne bacteria including escherichia coli, proteus vulgaris, staphylococcus aureus, bacillus subtilis and bacillus cereus, with the minimum inhibitory concentration (mic) a ...201122104118
synthesis and biological evaluation of some thiazolidinones as antimicrobial agents.a novel series of thiazolidinone derivatives namely 4-(4-dimethylamino-6-{4-[5-(4-ethylpiperazin-1-ylmethyl)-4-oxo-2-phenylthiazolidin-3-yl]-phenylamino}-[1,3,5]triazin-2-yloxy)-1-methyl-1h-quinolin-2-one have been synthesized from the key intermediate 4-[4-(4-aminophenylamino)-6-dimethylamino-[1,3,5]triazin-2-yloxy]-1-methyl-1h-quinolin-2-one (7). condensation reaction of compound 7 with different aldehyde derivatives were performed to obtain schiff base derivatives, which after cyclization gav ...201122182927
[the susceptibility of proteus mirabilis strains isolated from white stork (ciconia ciconia)].proteus sp. rods are ubiquitous bacteria, widespread in the environment and classified also as opportunistic human pathogens. the aim of our study was to evaluate susceptibility of proteus mirabilis strains isolated from white stork (ciconia ciconia) regarding as his natural bacterial flora, compare and discuss their results with data obtained from scientific literature for clinical strains of the same species. susceptibility of 59 p. mirabilis strains was estimated for 27 antimicrobials using d ...201122184908
antimicrobial activity and phytochemical screening of serial extracts from leaves of aegle marmelos (linn.).the in vitro antimicrobial activity of serial petroleum ether, chloroform and methanol extracts from leaves of aegle mawmelos were investigated against bacterial and fungal species. all the extracts exhibited broad spectrum antimicrobial activity with zones of inhibition ranging from 10 to 22 mm against bacteria: staphylococcus aureus, beta streptococcus haemolyticus group a, proteus mimrabilis, klebsiella pneumoniae, pseudomonas aenrginosa, escherichia coli, salmonella typhi, fungi: candida alb ...201121928713
serotyping of proteus mirabilis clinical strains based on lipopolysaccharide o-polysaccharide and core oligosaccharide structures.the aim of this work was to serotype proteus mirabilis urinary tract infection (uti) strains based on chemically defined o-antigens with the use of two clinical collections from sweden and poland consisting of 99 and 24 uti strains, respectively. a simple two-step serotyping scheme was proposed using enzyme immunoassay with heat-stable surface antigens of proteus cells and immunoblotting with isolated lipopolysaccharides (lpss). using polyclonal anti-p. mirabilis rabbit antisera, 50 swedish and ...201121999547
characterisation of the microbiota of atlantic mackerel (scomber scombrus).in this study the microbiota of atlantic mackerel (scomber scombrus) collected by a commercial purse seiner was examined. fish were collected directly from the purse seine and from the refrigerated sea water (rsw) transport tank after loading. the culturable microbiota and specific spoilage bacteria (ssb) were quantified on iron agar lyngby (ial) and identified using commercially available biochemical api® kits on pure cultured isolates. these kits showed to be sub-optimal in characterising the ...201121914558
role of the umo proteins and the rcs phosphorelay in the swarming motility of the wild type and an o-antigen (waal) mutant of proteus mirabilis.proteus mirabilis is a gram-negative bacterium that exists as a short rod when grown in liquid medium, but during growth on surfaces it undergoes a distinct physical and biochemical change that culminates in the formation of a swarmer cell. how p. mirabilis senses a surface is not fully understood; however, the inhibition of flagellar rotation and accumulation of putrescine have been proposed to be sensory mechanisms. our lab recently isolated a transposon insertion in waal, encoding o-antigen l ...201122139504
[virulence factors in proteus spp. bacteria isolated from urinary tract infections: their detection and importance].nosocomial infections associated with biofilm formation have been a serious problem in recent years. up to 32 % of them are urinary tract infections in patients with long-dwelling catheters. catheters represent an ideal surface for bacterial adhesion, facilitating easier colonization of the urinary tract. important pathogens causing these infections are bacteria of the genus proteus that colonize catheters not only by biofilm formation but also using other virulence factors. those were developed ...201122052099
antibiotic sensitivity profile of bacterial pathogens in postoperative wound infections at a tertiary care hospital in gujarat, india.to find out the most common bacterial pathogens responsible for post-operative wound infection and their antibiotic sensitivity profile.201121897707
antimicrobial and toxicological activities of five medicinal plant species from cameroon traditional medicine.infectious diseases caused by multiresistant microbial strains are on the increase. fighting these diseases with natural products may be more efficacious. the aim of this study was to investigate the in vitro antimicrobial activity of methanolic, ethylacetate (etoac) and hexanic fractions of five cameroonian medicinal plants (piptadeniastum africana, cissus aralioides, hileria latifolia, phyllanthus muellerianus and gladiolus gregasius) against 10 pathogenic microorganisms of the urogenital and ...201121867554
mutually facilitated dispersal between the nonmotile fungus aspergillus fumigatus and the swarming bacterium paenibacillus vortex.in the heterogeneous environment surrounding plant roots (the rhizosphere), microorganisms both compete and cooperate. here, we show that two very different inhabitants of the rhizosphere, the nonmotile fungus aspergillus fumigatus and the swarming bacterium paenibacillus vortex, can facilitate each other's dispersal. a. fumigatus conidia (nonmotile asexual fungal spores) can be transported by p. vortex swarms over distances of at least 30 cm and at rates of up to 10.8 mm h(-1). moreover, conidi ...201122106274
application of high-throughput sequencing to measure the performance of commonly used selective cultivation methods for the foodborne pathogen campylobacter.campylobacter is an important foodborne human pathogen, which has traditionally been studied using a variety of selective cultivation methods. here we use next-generation sequencing to ask the following: (i) how selective are commonly used campylobacter cultivation methods relative to the initial sample and (ii) how do the specificity and sensitivity of these methods compare with one another? to answer these questions, we used 16s rrna tagged-pyrosequencing to sequence directly from a pooled fec ...201122092388
influence of quorum sensing signal molecules on biofilm formation in proteus mirabilis o18.the influence of basis of quorum sensing molecules on proteus strains is much less known as compared to pseudomonas or escherichia. we have previously shown that a series of acylated homoserine lactones (acyl-hsl) does not influence the ureolytic, proteolytic, or hemolytic abilities, and that the swarming motility of proteus mirabilis rods is strain specific. the aim of the presented study was to find out if the presence of a series of acyl-hsl influences biofilm formation of p. mirabilis labora ...201122198843
prevalence of viral, bacterial and parasitological diseases in rats and mice used in research environments in australasia over a 5-y period.viral, bacterial and parasitological infections in rats and mice used in biomedical research continue to occur despite improved housing and biosurveillance. the presence of disease in laboratory animals can lead to spurious results for research undertaken in universities, research institutes and the pharmaceutical industry. here the authors report the results of serological, microbiological, parasitological and molecular tests done on mice and rats from australasia submitted to a rodent health m ...201122012194
the new variant of salmonella genomic island 1 (sgi1-v) from a proteus mirabilis french clinical isolate harbours blaveb-6 and qnra1 in the multiple antibiotic resistance region.the clinical strain of proteus mirabilis vb1248 isolated from a blood culture in august 2009 was multiresistant (i.e. resistant to β-lactams, fluoroquinolones, aminoglycosides and sulphonamides). we searched for the presence of a salmonella genomic island 1 (sgi1).201121846670
diagnosis and management of extensive vascular malformations of the lower limb: part i. clinical diagnosis.there is significant confusion in the literature when describing vascular anomalies, and vascular malformations are often misnamed or incorrectly classified. part i of this two-part series on the diagnosis and management of extensive vascular malformations of the lower limbs will discuss the dermatologist's role in the diagnosis of these lesions. at least nine types of vascular malformations with specific clinical and radiologic characteristics must be distinguished in the lower limbs: klippel-t ...201122000870
mutant akt1 in proteus syndrome. 201122129268
respiratory bacterial flora from healthy as well as respiratory symptoms' subjects.respiratory system is the primary settlement place of opportunistic organisms and considered as chief carrier of common respiratory pathogens. the aim of the study was to know the opportunistic organisms present in the healthy subjects as well as subjects that were suffering from respiratory symptoms. the organisms were identified as per standard bacteriological protocol and pathogenicity tests of the identified organisms were performed in mouse model. antibiotic sensitivity of the identified or ...201121902058
sublethal ciprofloxacin treatment leads to resistance via antioxidant systems in proteus mirabilis.this study investigates new aspects of the possible role of antioxidant defenses in the mechanisms of resistance to ciprofloxacin in proteus mirabilis. four ciprofloxacin-resistant variants (crvs), selected in vitro by repeated cultures in a sub-minimum inhibitory concentration (mic) concentration of ciprofloxacin, attained different levels of antibiotic resistance and high ferric reducing antioxidant power, with 10(-6) frequencies. however, no mutations occurred in positions 83 or 87 of gyra, ...201122092852
proteomic analysis of proteus mirabilis outer membrane proteins reveals differential expression in vivo vs. in vitro conditions.proteus mirabilis is an opportunistic pathogen that frequently causes complicated urinary tract infections. among a wide spectrum of potential virulence factors, outer membrane proteins (omps) are critical for bacterial interactions and survival in different environments. in this work, we used a proteomic approach to assess p. mirabilis in vivo omps expression compared to in vitro, including iron replete and iron-restricted conditions. three putative iron receptors, irea, pmi0842, and pmi2596, w ...201122077220
biofouling characteristics and identification of preponderant bacteria at different nutrient levels in batch tests of a recirculating cooling water system.understanding the influence of nutrient levels on biofouling control is an important requirement for management strategies in a recirculating cooling water system. nutrient limitation may be one way to control biofouling development without increasing biocide dosing. therefore, this study was carried out to investigate the effects of nutrient levels on biofouling characteristics and to identify the preponderant bacteria in the batch tests with a simulated cooling water system. the biofouling cha ...201121879565
clinical and bacteriological profile of urinary tract infection in children at nepal medical college teaching hospital.the aim of this study was to study the clinical and bacteriological profile of urinary tract infection (uti) in children. this was a prospective study of 40 culture positive cases of uti in children who attended pediatric outpatient department of nepal medical college teaching hospital. uti was more common in female (65.0%) than in male (35.0%). half were in the age group 1- 5 years. fever was the most common presentation (65.0%) followed by abdominal pain (42.5%), decreased appetite (37.5%) and ...201121991696
activities of jatropha curcas phorbol esters in various bioassays.jatropha curcas seeds contain 30-35% oil, which can be converted to high quality biodiesel. however, jatropha oil is toxic, ascribed to the presence of phorbol esters (pes). in this study, isolated phorbol ester rich fraction (peef) was used to evaluate the activity of pes using three aquatic species based bioassays (snail (physa fontinalis), brine shrimp (artemeia salina), daphnia (daphnia magna)) and microorganisms. in all the bioassays tested, increase in concentration of pes increased mortal ...201122172520
colonisation and infection due to enterobacteriaceae producing plasmid-mediated ampc β-lactamases.to investigate the epidemiology and clinical features of infections caused by enterobacteria producing plasmid-mediated ampc β-lactamases (pampc), which are emerging as a cause of resistance to extended-spectrum cephalosporins.201122138600
genetic features of blandm-1-positive enterobacteriaceae.genetic features associated with the bla(ndm-1) gene were investigated in 6 escherichia coli, 7 klebsiella pneumoniae, 1 citrobacter freundii, 1 proteus mirabilis, and 1 providencia stuartii isolate of worldwide origin. clonal diversity was observed for both e. coli and k. pneumoniae. the bla(ndm-1) gene was carried by different plasmid types (inca/c, incf, incl/m, or untypeable) and was likely chromosome borne in two isolates. the bla(ndm-1) plasmids coharbored a variety of resistance determina ...201121859933
photoletter to the editor: oral ulceration in pyoderma gangrenosum.a 65-year-old woman presented with widespread necrotising cutaneous ulceration and oral involvement. past history included rheumatoid arthritis, and a left nephrectomy.examination revealed multiple violaceous undermined ulcers. blood investigations showed an acute inflammatory response. skin histopathology showed epidermal ulceration with acute and chronic inflammation. direct immunofluorescence was negative. a diagnosis of pyoderma gangrenosum with oral involvement was made. mycophenolate mofet ...201121894254
penile reconstruction for a case of genital lymphoedema secondary to proteus syndrome.to our knowledge penile lymphoedema secondary to proteus syndrome has not previously been reported. hence we report a case of a 16-year-old male who was referred with features of right hemi-hypertrophy and severe lymphoedema affecting his scrotum and penis. he had previously undergone scrotal reduction surgery at the age of 13, but had since developed worsening penile oedema. his main concern was that of cosmetic appearance prior to sexual debut, and he also complained of erectile dysfunction. a ...201122084799
the microbial flora associated with oral carcinomas.changes in the microbial flora on the oral mucosa after cancerous alteration may lead to both local and systemic infections. in this study, we assessed the microbial flora associated with the surfaces of oral squamous cell carcinoma. a comparative evaluation of these microbial contents was made with that of the contralateral healthy mucosa and control (healthy) mucosa. we also assessed the microbial flora from the saliva culture in subjects with oral squamous cell carcinoma and healthy controls.201121909494
the rising problem of antimicrobial resistance in the intensive care unit.abstract: mainly due to its extremely vulnerable population of critically ill patients, and the high use of (invasive) procedures, the intensive care unit (icu) is the epicenter of infections. these infections are associated with an important rise in morbidity, mortality, and healthcare costs. the additional problem of multidrug-resistant pathogens boosts the adverse impact of infections in icus. several factors influence the rapid spread of multidrug-resistant pathogens in the icu, e.g., new mu ...201122112929
Gram stain microbiological pattern of upper extremities suppuration at Baptist Medical Centre, Ogbomoso Nigeria: a fifteen month review.Sixty-eight (68) patients with serious upper extremity suppurative infections, presenting within a period of fifteen (15) months, were prospectively studied clinically, Gram stain of aspirates/pus were performed, specimen cultured, planted, and where indicated glucose levels and haemoglobin genotype determined. Half of the patients had hand infections. Staphylococcus aureus was isolated from thirty-nine (39) patients. Gram Negative bacilli, including Salmonella were more isolated from patients w ...201122195385
Preventing catheter-related urinary tract infection: focus on Proteus mirabilis.Urinary tract infectious caused by Proteus are uncommon, and account for only 1-2% of community-acquired infectious. However, it is important that staff are able to recognise the features of a Proteus infection. Proteus infections, if unrecognised, can become established and cause major health problems. Proteus is more common in people who have or have had a urinary catheter. Minimizing the incidence and duration of urinary catheterization is an important part of preventing infection. Community ...201122145192
Macrodystrophia lipomatosa involving multiple nerves.Macrodystrophia lipomatosa (MDL), a rare congenital disorder, is considered by some to be a localized form of Proteus syndrome. The implication of the PTEN (phosphatase and tensin homolog deleted on chromosome 10) gene in both strengthens this belief. We present a case who had MDL in multiple nerve territories-all on the same side of the body-with hypertrophy of mainly fibroadipose tissue throughout their distribution, thus pointing to a form of localized hemihypertrophy; both hemihypertrophy an ...201121948052
[effect of acetylcholine and acetylcholinesterase on the activity of contractile vacuole of amoeba proteus].acetylcholine (ach, 1 microm) stimulates activity of the contractile vacuole of proteus. the effect of ach is not mimicked by its analogs which are not hydrolyzed by acetylcholinesterase (ache), i. e., carbacholine and 5-methylfurmethide. the effect of ach is not sensitive to the blocking action of m-cholinolytics, atropine and mytolone, but is suppressed by n-cholinolytic, tubocurarine. the inhibitors of ache, eserine (0.01 microm) and armine (0.1 microm), suppress the effect of ach on amoeba c ...201121870511
Structure of the core part of the lipopolysaccharide from Proteus mirabilis genomic strain HI4320.The structure of the core part of the lipopolysaccharide from Proteus mirabilis genomic strain HI4320 was studied. Core oligosaccharide was isolated by mild acid hydrolysis of the lipopolysaccharide and analyzed by NMR spectroscopy and mass spectrometry as well as chemical methods. The structure of the oligosaccharide was established.201121999542
Pulmonary Zygomycosis with Cunninghamella bertholletiae in a Killer Whale (Orcinus orca).An adult female killer whale (Orcinus orca) was transported to the Port of Nagoya public aquarium in June 2010. While the animal was being maintained in the aquarium there was a gradual decrease in body weight. On October 1st, 2010 the whale exhibited signs of gastrointestinal disease and died on January 14th, 2011. At necropsy examination the gastric compartments were filled with a large number of variably-sized rocks (total weight 81.4 kg) and there was marked ulceration in the third compartme ...201122000035
proteus mirabilis biofilms and catheter-associated urinary tract infections.proteus mirabilis inhabits the environment and causes a number of infections including those of the skin, respiratory tract, wounds and urinary tract. these organisms express virulence factors associated with adhesion, motility, immunoavoidance, nutrient acquisition, host damage, as well as biofilm formation. p. mirabilis produces biofilms in diverse habitats with those formed in the human host playing a key role in indwelling device infections. the most studied p. mirabilis biofilms are those f ...201121921687
radial and spiral stream formation in proteus mirabilis colonies.the enteric bacterium proteus mirabilis, which is a pathogen that forms biofilms in vivo, can swarm over hard surfaces and form a variety of spatial patterns in colonies. colony formation involves two distinct cell types: swarmer cells that dominate near the surface and the leading edge, and swimmer cells that prefer a less viscous medium, but the mechanisms underlying pattern formation are not understood. new experimental investigations reported here show that swimmer cells in the center of the ...201122219724
Proteus penneri lurking in the intensive care unit: An important often ignored nosocomial pathogen. 201122013265
Isolation and identification of antibacterial compound from the leaves of Cassia auriculata.Antimicrobial properties of medicinal plants and plant parts such as flowers, roots, fruits, seeds and oils are being used to cure some chronic and acute diseases throughout the world. In the present study, an attempt has been made to isolate and identify the antibacterial compound present in the leaves of the Cassia auriculata.201122013726
[evaluation of biofilm formation by proteus mirabilis strains on the surface of different biomaterials by two methods].proteus sp. rods are opportunistic human pathogens. these microorganisms are mainly isolated from patients with urinary tract infections, particularly associated with using of biomaterials, on which surface they can form biofilm. the aim of our study was the estimation of proteus mirabilis rods ability to form biofilm on the surface of 5 biomaterials (polychloride vinyl, silicone latex, polypropylene, polybutylen teraftalan and polyamide) using richards' and quantitative method and comparison re ...201122184907
anthemis wiedemanniana essential oil prevents lps-induced production of no in raw 264.7 macrophages and exerts antiproliferative and antibacterial activities in vitro.anthemis wiedemanniana is known in folk medicine for the treatment of microbial infections, cancer and also urinary and pulmonary problems. in this study, the chemical composition of the essential oil from a. wiedemanniana was evaluated and its antibacterial activity was tested against 10 bacterial strains. the oil was also tested for its potentiality to inhibit nitric oxide production in raw 264.7 macrophages and for its cytotoxicity against four human cancer cell lines. a. wiedemanniana oil, r ...201122124231
outbreak caused by proteus mirabilis isolates producing weakly expressed tem-derived extended-spectrum β-lactamase in spinal cord injury patients with recurrent bacteriuria.we performed a retrospective extended-spectrum β-lactamase (esbl) molecular characterization of proteus mirabilis isolates recovered from urine of spinal cord injury patients. a incorrectly detected tem-24-producing clone and a new weakly expressed tem-derived esbl were discovered. in such patients, esbl detection in daily practice should be improved by systematic use of a synergy test in strains of p. mirabilis resistant to penicillins.201121888562
Cerebral Abscess Complicating Proteus mirabilis Meningitis in a Newborn Infant.Neonatal bacterial meningitis is associated with high morbidity and mortality, especially when complicated by intracranial abscesses. The authors report the case of an 11-day-old female with Proteus mirabilis meningitis complicated by an asymptomatic brain abscess. With this report, the authors illustrate the importance of surveillance neuroradiologic imaging in patients with Proteus meningitis.201122114212
antibacterial activities of 4-substituted-2-[(e)-{(1s,2r)/(1r,2s)-1-hydroxy-1-phenylpropan-2-ylimino}methyl]phenol.a series of norephedrine-based schiff bases (1a-6a and 1b-6b) were synthesized by reacting substituted salicylaldehydes with d-norephedrine or l-norephedrine. the structure of these compounds was confirmed by elemental analyses and spectroscopic techniques. the molecular structures of 5a and 6a have been determined by x-ray crystallography, which revealed that the compounds are in the oxoamino form, with bent intramolecular n-h···o (n···o ≈ 2.58 å) hydrogen bonds and that they are associated in ...201122098701
Use of a DNA microarray for detection and identification of bacterial pathogens associated with fishery products.We established a microarray for the simultaneous detection and identification of diverse putative pathogens often associated with fishery products by targeting specific genes of Listeria monocytogenes, Salmonella, Shigella, Staphylococcus aureus, Streptococcus pyogenes, Vibrio cholerae, Vibrio parahaemolyticus, Vibrio vulnificus, and Yersinia enterocolitica and the 16S-23S rRNA gene internal transcribed spacer (ITS) region of Proteus mirabilis and Proteus vulgaris. The microarray contained 26 sp ...201121965411
multiple origins of endosymbiosis within the enterobacteriaceae (gamma-proteobacteria): convergence of complex phylogenetic approaches.abstract: background: the bacterial family enterobacteriaceae gave rise to a variety of symbiotic forms, from the loosely associated commensals, often designated as secondary (s) symbionts, to obligate mutualists, called primary (p) symbionts. determination of the evolutionary processes behind this phenomenon has long been hampered by the unreliability of phylogenetic reconstructions within this group of bacteria. the main reasons have been the absence of sufficient data, the highly derived nat ...201122201529
Impact of adopting minimum inhibitory concentration as the determinant of susceptibility to cephalosporins and carbapenems in multi-drug resistant Enterobacteriaceae.The Clinical and Laboratory Standards Institute has recommended that Enterobacteriaceae susceptibility to most cephalosporins and carbapenems be reported according to minimum inhibitory concentration (MIC) alone. We analyzed our record of multi-drug resistant Enterobacteriaceae to assess the impact of these changes. We compared susceptibilities of ceftriaxone-resistant Enterobacteriaceae when using the 2009 and new 2010 MIC standards. Vitek2® (BioMerieux), was used to assess the changes in susce ...201121912922
urinary pathogens and drug susceptibility patterns of urinary tract infections among antenatal clinic attendees in ibadan, nigeria.aim:  to determine the bacterial agents involved in urinary tract infections in pregnant women and their antibiotic susceptibility patterns in ibadan, nigeria. methods:  all consenting subjects who attended antenatal clinics of the university college hospital and adeoyo maternity hospital, ibadan, nigeria, from 1 april 2007 and 30 march 2009 were interviewed to obtain demographic and pregnancy health data. mid-stream urine samples obtained were processed by standard methods. confirmed bacterial ...201121917070
Microbiology of the chronic suppurative otitis media.The aim of the study was to determine aetiological agents of chronic suppurative inflammation of the middle ear and their susceptibility to antibiotics, which could lead to better therapeutic decisions and consequently avoidance of appearance of resistance to specific antibiotics. Most frequently isolated agents were Staphylococcus aureus (30.6%), Pseudomonas aeruginosa (22.4%), Klebsiella spp. (10.6%) and Proteus spp. (7.1%). None of the isolates were resistant to ciprofloxacin. High sensitivit ...201121849954
predictors of surgical site infections of the abdomen in lagos, nigeria.the issue of nosocomial infection constitute a significant burden on any health care facility particularly in resource constrained centers of many developing countries.201121913509
Participation of mast cells in chronic otitis media.In the pathogenesis of chronic otitis media (COM), much attention is paid to the molecular mechanisms of local inflammatory reactions in which mast cells (MCs) may be involved due to their role not only in allergic but also inflammatory processes. The aim of this study was to assess the density of mast cells in chronic otitis media in relationship to different clinical courses of COM, bacterial infections and types of disease. The MCs expression was measured immunohistochemically in paraffin-emb ...201122038229
dissemination of the rmtb gene carried on incf and incn plasmids among enterobacteriaceae in a pig farm and its environment.to investigate the prevalence and characterization of 16s rrna methylase-producing bacteria in a pig farm and its environment in east china.201121852287
description and plasmid characterization of qnrd determinants in proteus mirabilis and morganella morganii.clin microbiol infect abstract: we investigated the presence of qnrc and qnrd among 756 non-replicate enterobacteriaceae isolated in italy, selected for being non-susceptible to fluoroquinolones and/or resistant to third-generation cephalosporins. four proteus mirabilis and one morganella morganii (0.66% of the total) presented a qnrd gene, located in a 2687-base-pair plasmid that was entirely sequenced. the plasmid is un-typable, and contains no known coding region other than qnrd. that the qnr ...201122192340
chromosomal integration and location on inct plasmids of the blactx-m-2 gene in proteus mirabilis clinical isolates.analysis of five ctx-m-2-producing proteus mirabilis isolates in japan demonstrated that bla(ctx-m-2) was located on the chromosome in four isolates and on inct plasmids in three isolates, including two isolates that also carried the gene on the chromosome. in all four isolates with chromosomal bla(ctx-m-2), isecp1 was responsible for the integration of the gene into the chromosome. three different sites in the p. mirabilis genomic sequence were utilized as integration sites.201122106217
phytochemical constituents and antibacterial efficacy of the flowers of peltophorum pterocarpum (dc.) baker ex heyne.to investigate the preliminary phytochemistry and antibacterial activity of the flower extract of peltophorum pterocarpum .201121967698
[evaluation of chromogenic medium uriselect4 in urine culture].we evaluated the performance and the cost of chromogenic medium uriselect4 agar with regard to the standard medium for the detection and identification of urinary tract pathogens. a total of 503 clinical urine specimens containing leucocytes greater or equal to 104/ml were analysed prospectively, in parallel by two different persons on blood agar (gs) and uriselect4 according to the manufacturers' instructions. of the 503 urine specimens tested, 210 gave a positive culture on uriselect4 versus 1 ...201122008133
Deciphering simultaneous bioelectricity generation and dye decolorization using Proteus hauseri.This first-attempt study disclosed how and why electron-shuttling mediators were capable to stimulate bioelectricity-generating capabilities of dye-bearing microbial fuel cells (MFCs) using Proteus hauseri. Due to significant biotoxicity of 4-aminophenol (4AP) and the absence of electron-mediating potential of 3AP, only 2AP among all isomers could work as an exogenous mediator to stimulate bioelectricity generation of P. hauseri. Dye toxicity to cells on anodic biofilm in MFCs apparently affecte ...201122178022
development of a specific polymerase chain reaction assay for the detection of basidiobolus.the aethiology of chronic diarrhoea is complex in humans and animals. it is always necessary to evaluate a list of differential diagnosis, including bacteria, protozoa and fungi. basidiobolomycosis is a fungal disease reported sporadically worldwide, mainly caused by b. ranarum, a frequent organism found in soil or in the intestine and skin of lizards and frogs. it is an opportunistic infection characterized by granulomatous lesions in the subcutaneous tissues but also in the intestine wall in h ...201122075784
Comparative study of antimicrobial activity and phytochemical analysis of methanolic and aqueous extracts of the fruit of Emblica officinalis against pathogenic bacteria.To investigate antimicrobial potential of aqueous (infusions, decoctions) and methanlic extracts (1:2 and 1:5 concentrations) of Emblica officinalis (amla) against seven pathogenic bacteria namely Staphylococcs aureus, Staphylococcus saprophyticus, Escherichia coli, Enterococcus faecalis, Enterococcus cloacae, Proteus vulgaris and Klebsiella pneumoniae.201121977871
identifying patients harboring esbl-producing enterobacteriaceae on hospital admission: derivation and validation of a scoring system.increases in community-acquired infections caused by extended-spectrum β-lactamase (esbl)-producing enterobacteriaceae have important implications for hospital infection control and empirical antibiotic therapy protocols. we developed and validated a tool for identifying patients harboring these organisms at hospital admission. we retrospectively analyzed chart data for 849 adult inpatients. the derivation cohort included 339 patients admitted to a large rome hospital during 2008, with (n=113) o ...201121537020
antimicrobial resistance in urinary tract pathogens in canada from 2007 to 2009: canward surveillance study.from january 2007 to december 2009 an annual canadian national surveillance study (canward) tested 2943 urinary culture pathogens for antimicrobial susceptibilities following clinical and laboratory standards institute (clsi) guidelines. the most frequently isolated urinary pathogens (n, % of all isolates) were escherichia coli (1581, 54%), enterococci (410, 14%), klebsiella pneumoniae (274, 9%), proteus mirabilis (122, 4%), pseudomonas aeruginosa (100, 3%), and staphylococcus aureus (80, 3%). r ...201121537027
in vitro antimicrobial efficacy of a silver alginate dressing on burn wound isolates.to test the antimicrobial effectiveness of a silver alginate dressing on opportunistic pathogens, namely meticillin-sensitive staphylococcus aureus (mssa) and meticillin-resistant staphylococcus aureus (mrsa), klebsiella spp., enterococcus faecalis, enterococcus faecium, pseudomonas aeruginosa, escherichia coli, enterobacter sakazakii, enterobacter cloacae, serratia marcescens, chryseobacterium indologenes, proteus vulgaris and acinetobacter baumannii.201121537295
synthesis and antimicrobial activities of hexahydroimidazo[1,5-a]pyridinium bromides with varying benzyl substituents.variously substituted benzyl bromides were employed to quaternize hexahydrobenzylimidazo[1,5-a]pyridine (a) and the resulting bromides (1-11) were evaluated for their in vitro antimicrobial activity against 10 pathogenic microorganisms: staphylococcus aureus, staphylococcus epidermidis, bacillus cereus, micrococcus luteus, proteus vulgaris, escherichia coli, salmonella typhimurium, klebsiella pneumonia, candida albicans and candida krusei. antimicrobial activities were surprisingly high (mic: 0. ...201121543140
improved detection of ampc β-lactamases in escherichia coli, klebsiella pneumoniae, and proteus mirabilis using new susceptibility breakpoints for third-generation cephalosporins. 201121549542
identity gene expression in proteus mirabilis.swarming colonies of independent proteus mirabilis isolates recognize each other as foreign and do not merge together whereas apposing swarms of clonal isolates merge with each other. swarms of mutants with deletions in the ids gene cluster do not merge with their parent. thus ids genes are involved in the ability of p. mirabilis to distinguish self from non-self. here we have characterized expression of the ids genes. we show that idsabcde and f are transcribed as an operon, and we define the p ...201121551301
n-substituted aminomethanephosphonic and aminomethane-p-methylphosphinic acids as inhibitors of ureases.small unextended molecules based on the diamidophosphate structure with a covalent carbon-to-phosphorus bond to improve hydrolytic stability were developed as a novel group of inhibitors to control microbial urea decomposition. applying a structure-based inhibitor design approach using available crystal structures of bacterial urease, n-substituted derivatives of aminomethylphosphonic and p-methyl-aminomethylphosphinic acids were designed and synthesized. in inhibition studies using urease from ...201121559954
clinical features and long-term follow-up of quasi-moyamoya disease in children.background: inherited or acquired disorders and conditions may present in conjunction with moyamoya disease. this condition is known as quasi-moyamoya disease. methods: a retrospective review of 69 moyamoya disease patients treated for the past 20 years identified 7 patients with quasi-moyamoya disease and 5 of them were pediatric patients. results: the mean age at initial diagnosis was 6.4 years (range 5-9). associated disorders were: craniosynostosis, dwarfism with coarctation of aorta, proteu ...201121576916
[beta-lactamases of clinical isolates of enterobacteriaceae family].among 62 clinical strains of enterobacteria, isolated from intestinal tract, representatives of genus escherichia made--67.4%, klebsiella--4.84%, citrobacter--4.84%, enterobacter--8.06%, proteus--6.45%, morganella of 8.06%. preparations of fluorquinolone group--gatifloxacin and moxifloxacin, the number of steady strains being from 0.0% to 33.3%, were the most effective in respect of enterobacteria the investigated strains of enterobacteria showed considerable resistance to beta-lactam antibiotic ...201121598655
Refresh
firstprev
...141142143144145146147148149150...
nextlast
Displaying items 14901 - 15000 of 15180