Publications

[regulation of catalase synthesis in proteus mirabilis].	during the log-phase growth of proteus mirabilis the specific activity of catalase decreases, while at the beginning of or during the stationary phase an increase takes place which is abolished by inhibitors of nucleic acid or protein synthesis. glucose in the culture medium has no appreciable effect on the level of enzyme synthesis nor does the passage of bacteria to anaerobiosis bring any noticeable change. successive additions of hydrogen peroxide up to weak final concentrations (0.2--0.5 mm) ...	1979	378338
alterations in the cell envelope composition of proteus mirabilis during the development of swarmer cells.	long, swarming cells of proteus mirabilis had different proportions of some lipopolysaccharide components when compared to short cells, either agar grown or broth grown. fluorescence spectrophotometry of antibody binding, and sodium dodecyl sulphate-polyacrylamide gel electrophoresis indicated that the change was in the proportion of lipopolysaccharide with long o-antigenic sidechains, swarmer lipopolysaccharide relative to short sidechain lipopolysaccharide than the non-swarming cells. the prot ...	1979	378265
determination of lipopolysaccharide by a bioluminescence technique.	the determination of the lipid a content of bacterial lipopolysaccharide by using a dim mutant of the luminous bacterium beneckea harveyi is described. the luminous bacteria emitted light upon the addition of an acid hydrolysate of lipopolysaccharide which contained myristic acid, thus making it possible to detect as little as 1 ng of lipopolysaccharide. by converting the 3-oh-myristic acid to myristic acid, it was possible to further increase the detection sensitivity and to establish a basis f ...	1979	378133
changes in the pathogenesis and detection of intrahepatic abscess.	a comparison of two distinct 11 year time periods at our institution demonstrated a change not only in the cause of intrahepatic abscess but also in the procedures used to diagnose this condition. significant improvement in the methods of detection of intrahepatic abscess permits earlier diagnosis and therapy and thus a significantly improved prognosis.	1979	378006
the impact of hospitalization on the aerobic fecal microflora.	quantitative bacteriological analysis of the aerobic fecal microflora of 75 patients indicated that, at the time of admission to hospital, escherichia coli were the predominant fecal aerotolerant bacteria. subsequent fecal samples showed a progressive supplantation of e coli by klebsiella, enterobacter and proteus. at the end of 21 days of hospitalization, e coli remained predominant in only 30 patients. none of the patients had received antibiotics, undergone surgery or been subjected to x-ray ...	1979	377964
late deoxyribonuclease activity of salmonell enteritidis.	as a result of chance observations, the authors studied for deoxyribonuclease activity 16 strains of salmonella, including six fresh isolates and ten stock cultures, with positive results in 13. reactions characteristically occurred at 48 hours or later, with the majority being manifest at 72 hours and the latest at six days. no other positive reaction was observed among approximately 7,000 enterobacteriaceae tested, except for serratia species and proteus vulgaris. deoxyribonuclease screening p ...	1979	377948
studies on the influence of competitive enterobacteriaceae flora on salmonella isolation.		1979	377858
[antibacterial effect of ankerplast spray].	the diffusion test yielded no satisfactory results. in the tube test, both the spray and the solvent (in a dilution of 1:4 and 1:8, respectively) proved to be bacteriostatically active against enterococci, staphylococcus aureus, escheria coli, proteus, and pseudomonas aeruginosa. these germs were killed within 30 minutes in the test for bactericidal activity, whereas the reference substance (1% phenol) required 1--2 hours, except against the last-named germ. even the copolymer exerted a bacteric ...	1979	377580
a comparison of the antibacterial activity of sulphonamide-trimethoprim combinations.	sensitivity patterns of 326 clinical isolates toward sulphonamide/trimethoprim combinations were tested in vitro. the relative merits of the different combinations are discussed in their pharmacological and bacteriological contexts. it is concluded that organisms sensitive to cotrimoxazole as judged by in vitro sensitivity tests performed at 37 degrees c are also sensitive to sulphamoxole/trimethoprim.	1979	377523
indomethacin and occult infections.		1979	376879
factors which influence the electron microscopic appearance of dna when benzyldimethylalkyammonium chloride is used.		1979	376868
urinary tract infection re circumcision.		1979	376804
a nosocomial outbreak of infections due to multiply resistant proteus mirabilis: role of intestinal colonization as a major reservoir.	an outbreak of nosocomial infections involving an unusual strain of multiply resistant proteus mirabilis (phage type 8888) occurred in 15 patients, 14 of whom were in the surgical intensive care unit at that time. no common source of infection was identified, and person-to-person transmission was the most likely mode of spread. case-control analysis indicated a significantly increased risk infection related to length of hospital stay (p less than 0.005), number of operations (p less than 0.005), ...	1979	376760
prevention of colonization of the urinary tract of mice with escherichia coli by blocking of bacterial adherence with methyl alpha-d-mannopyranoside.	methyl alpha-d-mannopyranoside (alpha mm), a competitor inhibitor of the binding of mannose by escherichia coli, was tested for its ability to prevent infection of the urinary tract of mice with infective strains of the organisms. injection of the bacteria in the presence of the drug resulted in a considerable reduction in the number of bacteriuric mice. in this system alpha mm was inactive against proteus mirabilis in accordance with its inability to inhibit the adherence of this organism to ep ...	1979	376757
in vitro sensitivity of proteus organisms to gentamicin and sisomicin.	the antibacterial activity of gentamicin and sisomicin was studied in 148 recent clinical isolates of proteus obtained from patients hospitalized in athens. both gentamicin and sisomicin were found to be active with sisomicin generally being the more active of the two; p. mirabilis strains were less susceptible than the indole-positive strains, but p. mirabilis organisms isolated from the respiratory tract were more sensitive to sisomicin than those isolated from the urine. susceptibility testin ...	1979	376234
recent notes on the mechanism of the proteus swarming phenomenon. a review.		1978	375874
[mechanisms of proteus resistance to chloramphenicol].	data on chloramphenicol sensitivity of clinical proteus strains isolated within 1970--1975 and some mechanisms of their resistance to this antibiotic are presented. it was found that most of the proteus strains (62.82 +/- 2.15 per cent) were resistant to chloramphenicol. 75 per cent of the isolates had resistance of transmissive character. resistance of the proteus cultures to chloramphenicol was not a stable feature and was lost during storage under laboratory conditions. direct correlation bet ...	1979	375826
[structure of the microflora of suppurative wounds and its sensitivity to antibiotics].	clinico-bacteriological examination of patients with purulent infections showed that staphylococcus was the predominating microflora in the wounds. simultaneously an increasing role of gram-negative conditionally pathogenic bacteria was shown. multiple drug resistance was found in the organisms tested. the highest sensitivity levels were observed to gentamicin, kanamycin, tetracycline, levomycetin. it was shown by means of special typing methods that staphylococci of phage group iii and ps. aeru ...	1979	375824
[expression of the gene for tetracycline resistance of plasmids r6 and rp4 in bacteria of the family enterobacteriaceae].	it was found that manifestation of the tetracycline resistance gene depended on the type of the plasmid containing the gene. the tetracycline resistance gene was subject to less repression in plasmid r6 than in plasmid rp4. sensitivity of the initial plasmid-free bacteria varied within lower dose ranges than that of the plasmid-carrying strains. regulation of the tetracycline resistance gene manifestation in the given plasmid may change in different bacterial hosts, i.e. in different cytoplasmic ...	1979	375821
enteric gram-negative rods, 1976.		1979	375729
reproducibility of biotypes using enterotubes.	using both stock and clinical isolates, the enterotube system was examined for reproducibility of its biotype identification. fifty stock strains of enterobacteriaceae were tested on each of 22 separate days (interrun evaluation), and ten enterotubes per strain were inoculated from one subculture (intrarun evaluation). it was found that 2 of the 50 strains (4 percent) demonstrated reproducibility of biotypes, defined as no variation in the results of the 22 interrun enterotubes. twenty-one of th ...	1979	375727
[effect of immunization on the radioresistance of mice to the action of 90sr].	the preliminary immunization with heated proteus vulgaris culture introduced in a single injection was found to have a positive influence on the resistance of white mice to radiation emitted by incorporated 90sr. this effect was manifested by an increase in the survival rate and the mean survival time of the animals, as well as by their increased physical endurance, and the stimulation of recovery process in the spleen.	1979	375634
[multiple drug resistance in different medical institutions: frequency and resistance patterns in escherichia coli, proteus mirabilis and klebsiella spec (author's transl)].		1979	375625
[probability of resistance to 10 standard- and 7 recently introduced antimicrobics in multiresistant strains of escherichia coli, proteus mirabilis and klebsiella spec (author's transl)].		1979	375624
[f' transfer from escherichia coli to proteus mirabilis].	the task of this work was the establishment of an effective transfer system for f'-plasmids from escherichia coli to proteus mirabilis. it is shown that cells of pg vi act as recipients in crosses with e. coli f' strains but with a low transfer rate of the plasmid. the presumption that a restriction -- modification system in p. mirabilis was the only reason for the low transfer could not be confirmed. an indirect selection method was developed to isolate p. mirabilis cells which are better recip ...	1979	375599
humidifier-associated extrinsic allergic alveolitis.	three cases of allergic alveolitis due to indoor humdification systems are described. thermoactinomyces vulgaris precipitins were detected in the serum of a 37-year-old female patient who had typical febrile attacks during exposure to cool-mist from a home humidifier. when the cause was detected and eliminated, the symptoms and signs disappeared and the woman's gas transfer factor improved from 56% to normal within six months. in a printing office a 60-year-old woman had had febrile attacks with ...	1979	375386
bacteriophage specificity in the identification of yersinia pestis as compared with other enterobacteria.	bacteriophage typing of yersinia pestis and the specificity of the phage among enterobacteriaceae were investigated. the bacteriophage used for rapid identification of y. pestis reacted with representative strains of all recognized species of shigella as well as with salmonella cholerae-suis. reactive shigella serotypes were sh. dysenteriae 1 and 9, sh. flexneri 2a, sh. boydii 1 and 6, and sh. sonnei. patterns consisting of isolated plaques (two cases) or absence of plaques were observed when th ...	1978	375327
microbial flora observed within sections of the oviduct in naturally mated, artificially inseminated, and virgin hens.		1978	375216
[urinous pleural effusion associated with obstructive nephropathy].		1978	374932
[effect of body sensitization on the indices of rheohepatography in patients with chronic cholecystitis].		1979	374858
[bactericidal activity of amoxicillin. in vitro bactericidal activity and therapeutic effect for experimental infections (author's transl)].		1979	374774
properties of r plasmid r772 and the corresponding pilus-specific phage pr772.	r plasmid r772 was isolated from a strain of proteus mirabilis and is a self-transmissible p-1 incompatibility group plasmid having a molecular weight of about 27 x 10(6). it renders bacterial hosts resistant to kanamycin. phage pr772 was isolated as a phage dependent on the presence of r772 in bacterial hosts. it is hexagonal-shaped with a diameter of 53 nm, has a thick inner membrane and no tail. vaguely defined appendages are sometimes apparent at some vertices and the phage possesses double- ...	1979	374677
gene copy number effects in the mer operon of plasmid nr1.	the level of resistance to hg2+ determined by the inducible mer operon of plasmid nr1 was essentially the same for three gene copy number variants in escherichia coli, less in proteus mirabilis, and intermediate in p. mirabilis "transitioned" to a high r-determinant gene copy number. cell-free volatilization rates of radioactive mercury indicated increasing levels of intracellular mercuric reductase enzyme from low- to high-gene copy number forms in p. mirabilis and from low- to high-copy number ...	1979	374374
endotracheally administered antibiotics for gram-negative bronchopneumonia.	sisomicin or a placebo was administered endotracheally to two groups of 18 and 20 unconscious patients, respectively, who had tracheostomies or endotracheal tubes in place and developed a severe gram-negative broncho-pneumonia. in addition, the patients received systemically a combination of sisomicin and carbenicillin. a favorable clinical response was obtained in 14 (77 percent) of the 18 patients who were treated with sisomicin and in nine (45 percent) of the 20 patients who received the plac ...	1979	374017
immunochemical studies on free lipid a from proteus mirabilis 1959.	the chemical composition and serological activity of free lipid a from proteus were studied. only two fatty acids: myristic acid and 3-hydroxymyristic acid were detected. when calculated for glucosamine disaccharide unit, 2 moles of ester-linked and 1 mole of amide-linked fatty acid are present. amino group of glucosaminyl residue is substituted by 3-hydroxymyristic acid. the occurence of an uncommon (4-aminoarabinose) substituent, attached outside the backbone, was noticed. the results of serol ...	1978	373679
[frozen and thawed bacteria as recipients of isolated phages and plasmid dna].	bacteria subjected to freezing and thawing are effective recipients of phage 1 phi 7 dna, lambda dna, and plasmid pmb9 dna. the effectiveness of transfection and plasmid transformation of frozen and thawed bacteria is determined by the joint action of 3 factors: 1) the conditions of freezing and thawing of a recipient and dna mixture with freezing carried out at a rate of 400 degrees c/min to--76 degrees c or--196 degrees c and with subsequent thawing at 42 degrees c; 2) a transitory character o ...	1979	373343
[express methods of determining the biochemical properties of pathogenic microorganisms].	comparative studies were carried out to evaluate some express methods for determining the biochemical properties of microorganisms. described are disc methods establishing the production of indol and h2s, the breakdown of urea, and the reduction of nitrates and nitrites, with which the time of investigation is shortened severalfold. the results obtained are clear and well defined, and fully agree with the results obtained by methods described in the bulgarian state standards. it is suggested to ...	1978	373232
dysuria in general practice.	an analysis of 98 clinical consultations for dysuria in an urban general practice revealed that only 60 percent of patients had proven urinary tract infections. two percent had gonorrhoea and the rest had an urethral syndrome. most of the urinary tract infections were caused by escherichia coli and streptococcus epidermidis. proteus mirabilis was the next commonest infecting organism. among the commonly used urinary antimicrobials, nitrofurantoin was found to be the cheapest and most effective a ...	1979	372868
the variable response of bacteria to excess ferric iron in host tissues.	the enhancement by exogenous ferric iron, both systemic and local, of the infectivity of 120 strains of bacteria, representing 17 genera, was measured in the skin of guinea-pigs. systemic iron enhanced only 23% of 115 strains, and local iron 49% of 71 strains. systemic iron, by an apparently anti-inflammatory action, depressed the size of lesions produced by 27 of the non-enhanced strains from nine of the genera tested. for most strains, the degree of enhancement was small, ranging from 2- to 8- ...	1979	372534
the special affinity of particular types of proteus mirabilis for the urinary tract.	the strains of proteus species found in significant numbers and as pure cultures in urine from 217 individuals were isolated, identified to species level and typed for proticine production (p type) and proticine sensitivity (s type) to give their p/s type. urinary-tract infections with proteus, principally p. mirabilis, were associated with the elderly. ninety seven distinct p/s types were found but three p/s types p3/s1,8, p3/s1,8,13 and p3/s1,13 were isolated at a much higher frequency (14%) t ...	1979	372530
genetic circularity of the proteus mirabilis linkage map.	the t incompatibility group plasmid r394 can mobilize the chromosome of proteus mirabilis strain pm5006. it transferred relatively large segments, corresponding to at least 20 min on the d plasmid chromosomal map of the organism. the frequency of recombination for a large number of selected markers was nearly constant at 5 x 10(-6) per donor cell and it is concluded that mobilization takes place from a number of chromosomal sites. all recombinants were r+ and displayed all properties of the plas ...	1979	372488
trimethoprim in combination with a sulfonamide for oral treatment of canine urinary tract infections.	trimethoprim, in combination with sulfadiazine or sulfamethoxazole was administered orally for 7 to 14 days to 84 dogs with urinary tract infections (uti). the daily dosage of 26.4 mg/kg (12 mg/lb) was divided into 2 equal parts and administered at about 12-hour intervals. response to treatment, based on negative urine culture during or after therapy, was 37 of 45 (82%) for uti caused by escherichia coli, 11 of 15 (73%) uti caused by proteus mirabilis, 8 of 12 (67%) uti caused by klebsiella pneu ...	1979	372165
endotoxin in germfree, gnotobiotic, or conventional-flora sprague-dawley rats.	the limulus assay for bacterial endotoxin was performed on serum and (or) plasma from animals monoassociated with clostridium species, staphylococcus aureus, escherichia coli, proteus mirabilis, enterobacter agglomerans, bacteroides fragilis, klebsiella pneumoniae, or candida albicans. plasma from animals monoassociated with the gram-negative bacteria or c. albicans consistently showed a positive limulus test while conventional-flora controls, germfree rats, and gnotobiotic animals monoassociate ...	1978	371771
[gibbs free energy in periodic enterobacterial cultures].	the authors present the results of study of the gibbs' free energy (--delta g) output in periodic cultures of nonpathogenic and enteropathogenic escherichia, shigellae, salmonellae, proteus, serratia, and klebsiellae in the hydrolysate broth in a special twelve--chamber cultivator. graphic expression--deltag = f(n) permitted to reveal differences in the energy characteristics of individual enterobacteria genera and species. it is supposed that such studies could be useful in the choice of redox ...	1978	371306
[tissue and bacterial sensitization in patients with bone pathology].	the author studied sensitization to normal tissues (bone, muscle, spleen) and tissues altered by pathological process (sequestrum, scars), and also to allergens of widespread causative agents of purulent infection (staphylococcus, streptococcus, proteus, e. coli) in 87 patients with different bone pathology and in 24 donors. leukocytolysis reaction (modified by karapaty) was used for ascertaining the sensitization; a total of 592 tests were conducted. with the development of infection in soft ti ...	1978	371297
[detection and study of the labile toxic factor of proteus mirabilis].	the author studied the dynamics of toxin formation of the high- and low-virulent pr. mirabilis strains. the high-virulent strain produced toxic substances of the exotoxin type detectable in 1-2-day broth cultures. later the activity of the culture medium of both cultures under study was due to substances of the endotoxin type. by physico-chemical and immunobiological properties, and also by chemical composition of pr. mirabilis "early toxin" was similar to the exoenterotoxins of enterobacteria. ...	1979	371267
[resistance of e. coli and bacteria of the genus proteus to the thermal processing of perishable meat products].	experiments were carried out in six meat combines to establish the devitalization of escherichia coli and bacteria of the proteus genus at the thermal treatment of perishable meat products. seventy series of experiments were conducted with 16 types of meat products of a different structure (homogenic and heterogenic), varying composition unequal diameter of the casings (3-4 am, 5-6 am, and 7-8 am), and different type of the latter--natural, paper, and cutis-lika. twenty-four-hour agar cultures a ...	1978	371114
patterns of infection in untreated acute leukemia: impact of initial hospitalization.	several previous authors have examined the association between infection and acute leukemia, especially at the time of death, but none has assessed this problem at the time of diagnosis and initial hospitalization. we have undertaken a retrospective review of cases of acute leukemia diagnosed at the affiliated hospitals of the state university of new york at buffalo. results suggest that bacteriologic findings in this population initially resemble those in the general outpatient population. gram ...	1979	371009
septicemia in children with cancer.	because of the persistently high mortality from sepsis in cancer patients, a retrospective study was designed to identify the causative organisms and to determine the factors affecting the outcome of sepsis. a total of 84 episodes of septicemia in 61 children with cancer were studied. the more frequently isolated organisms were: staphylococcus aureus (21.4%); escherichia coli (18%); klebsiella (7.1%); pseudomonas (6%); and bacteroides fragilis (6%). other isolates included proteus, serratia, aci ...	1979	371000
alteration of perirenal fat secondary to diffuse retroperitoneal infiltration.	inflammatory effusions and diffuse neoplasia in the fatty retroperitoneal space, which can alter the perirenal fat, can be recognized radiographically because of density differences. the opacity of fluid and tumor accentuates the remaining fat which conforms to the renal contour. this perirenal fatty border appears as a lucent strip when the perirenal fat is not violated and as abnormal perirenal streakiness when the perirenal fat is infiltrated by fluid or tumor. six cases are described.	1979	370904
[basic and clinical examinations of cs-1170 in pediatrics (author's transl)].	1. cs-1170 was administered for the purpose of prophylaxis during cardiac catheterization in patients with heart disease, and its blood levels were measured. 2. the mean blood level (moni-trol i standard) after one intravenous shot of 20 mg/kg was 53.6 mcg/ml in catheterized children aged below 6 and 66.9 mcg/ml in catheterized children aged above 10 at 30 minutes, and 1.95 mcg/ml and 5.2 mcg/ml respectively at 6 hours. 3. the mean half life of the blood level was 1.09 hours in catheterized chil ...	1979	370423
thermosensitive h1 plasmids determining citrate utilization.	twelve thermosensitive h1 plasmids from strains of salmonella typhi that had caused outbreaks of chloramphenicol-resistant typhoid fever in vietnam, thailand and india mediated citrate utilization (cit+) in a prototrophic escherichia coli k12 strain but not in the s. typhi strains from which they were derived. four h1 plasmids from a similar outbreak in mexico differed from the far eastern plasmids in not mediating citrate utlization but in mediating mercury resistance. h1 plasmids resembling th ...	1978	370344
typing methods for proteus rettgeri: comparison of biotype, antibiograms, serotype, and bacteriocin production.	two hunderd five strains of proteus rettgeri from epidemic and nonepidemic sources were differentiated by a new biotyping scheme, agglutination in o antisera, antimicrobial resistance patterns, and a new scheme based on bacteriocin production. the p. rettgeri were divided into 10 groups by their fermentation of lactose, sucrose, d-mannitol, and salicin. these groups were then subdivided into 19 biotypes by other biochemical reactions. bacteriocin production was tested by the cross-streak method. ...	1978	370146
pyogenic non-tuberculous spinal infection: an analysis of thirty cases.	thirty patients with non-tuberculous pyogenic osteomyelitis of the spine are reported in all of whom the diagnosis was confirmed bacteriologically, histologically or serologically. the clinical and radiological features and investigations are analysed. back pain, localised to the level involved, was the predominant symptom. the erythrocyte sedimentation rate was raised in all cases, and a characteristic sequence of radiological features is described.	1979	370121
[progress in antibacterial chemotherapy].		1978	370047
multicentre study of 'flagyl' in the prevention of post-operative anaerobic infection.	in a study carried out with 565 patients undergoing gynaecological and general surgical procedures, metronidazole ('flagyl') was used pre- and post-operatively and the incidence of post-operative infection, particularly that due to anaerobic organisms, was recorded. this was not a controlled study but, by comparison with other series, it would appear that the use of oral metronidazole had substantially reduced the likelihood of supervention of anaerobic sepsis. it is probable that the use of int ...	1979	369922
the recovery period following exposure of bacteria to penicillins.	experiments with staphylococcus aureus and streptococcus pyogenes have shown that when cells are exposed to bactericidal concentration of benzylpenicillin or ampicillin and the antibiotic then inactivated with beta-lactamase the count of the surviving viable cells (colony-forming units) remains essentially constant for a period of approximately 1.5--3 h before increasing at a normal rate. no such recovery period was observed, however, when escherichia coli or proteus mirabilis was exposed to a b ...	1979	369783
[gram-negative bacteria as agents of intrahospital infections].		1978	369251
conduit urinary diversion and urinary-tract infection. ii. raised serum antibody titers against escherichia coli and proteus mirabilis in relation to bacteriologic findings.	elevated serum antibody titers against escherichia coli and/or proteus mirabilis were found in 35% of 89 patients with a conduit urinary diversion. statistical analysis showed significant correlation between the titers and growth of e. coli or p. mirabilis in conduit urine. but 17 (24%) of 72 patients without e. coli in urine cultures had raised e. coli antibody titer. only 3 (4%) of 68 patients without growth of p. mirabilis had raised p. mirabilis antibody titer. when the post-diversion observ ...	1979	368977
conduiturinary diversion and urinary-tract infection. i. serum antibody titers against escherichia coli and proteus mirabilis in relation to urographic findings.	the serum antibody titers against escherichia coli and/or proteus mirabilis were elevated in 26 of 80 patients (33%) with a conduit urinary diversion. urographic findings were abnormal in 44 of these 80 patients (55%). urography was normal in 59% of the patients with normal antibody titers, but in only 15% of those with elevated titers. raised antibody levels against e. coli o antigen (greater than 256 before and/or greater than 32 after mercaptoethanol treatment of serum) were associated with w ...	1979	368976
penicillin-binding proteins in proteus species.	penicillin-binding proteins in three species of proteus, proteus mirabilis, p. morganii, and p. rettgeri, were investigated by sodium dodecyl sulfate-polyacrylamide slab gel electrophoresis. penicillin-binding proteins in these proteus species were compared with those in escherichia coli k-12. an approximate correlation between penicillin-binding proteins in e. coli and those in proteus species was shown by several criteria: electrophoretic mobilities; affinities of several beta-lactam antibioti ...	1979	368025
regulation of phenylalanine oxidase synthesis in proteus mirabilis.	cells of proteus mirabilis could oxidize l-phenylalanine to phenylpyruvate only when grown in the presence of a number of amino acids, particularly, l-alanine, l-asparagine, l-glutamate, and l-glutamine. production of phenylalanine oxidase was slowly lost upon growth in a minimal medium containing ammonium ions as a nitrogen source but was reversed by the addition of casein hydrolysate. oxidase activity as well as a phenylalanine-dichlorophenolindophenol (dcip) reductase activity increased in p. ...	1979	368013
the bacterial outer-membrane permeability of beta-lactam antibiotics.	two penicillins and 5 cephalosporins were evaluated for their ability to pass through the outer-membranes of proteus morganii, citrobacter freundii and escherichia coli. cefazolin, ceftezole and cephaloridine showed high permeability through the outer-membranes of these gram-negative bacteria. benzylpenicillin and cephalothin, on the contrary, showed low permeability. the outer-membrane permeability of ampicillin and cephalexin varied from species to species. c. freundii was found to have the hi ...	1979	368002
a new cephalosporin. sce-963: 7-[2-(2-aminothiazol-4-yl)-acetamido]-3-[[[1-(2-dimethylaminoethyl)-1h-tetrazol-5-yl]-thio]methyl]ceph-3-em-4-carboxylic acid. chemistry and structure-activity relationships.	the synthesis and the in vitro and in vivo antimicrobial activities of a series of 7-[2-(2-aminothiazol-4-yl)acetamido]cephalosporins (1) having varied 3-substituents, such as methyl, hydroxymethyl, acetoxymethyl, pyridiniomethyl and heterocyclicthiomethyls, are described. the derivatives having five membered heterocyclicthiomethyls exhibited strong inhibitory activities against gram-negative organisms including some strains of escherichia coli and proteus morganii which are insensitive to cefaz ...	1978	367998
macrophage secretion and the complement cleavage product c3a in the pathogenesis of infections by mycoplasmas and l-forms of bacteria and in immunity to these organisms.	mouse peritoneal macrophages in culture exposed to mycoplasma pulmonis show marked biochemical changes. this micro-organism induces the release of hydrolytic enzymes from macrophages. the release is time- and dose-dependent and is not associated with loss of the cytoplasmic enzyme lactate dehydrogenase or any other sign of cell death. secretory products of macrophages may play a role in the pathogenesis of chronic inflammatory responses elicited by mycoplasma infections. one of the products of a ...	1978	367651
microbial metabolites of tryptophan in the intestinal tract with special reference to skatole.		1979	367144
r plasmids in enterobacteriaceae from the hospital environment.	r plasmids have been demonstrated in several group of strains of enterobacteriaceae from hospital environment. r + enteropathogenic strains of escherichia coli were isolated from several items of baby-care as well as from the pre-prepared baby food in a newborn unit. strains from environmental samples are thought to be identical with those causing nosocomial gastroenteritis of babies. from hospital waste waters of another larger country hospital we could isolate r + strains of salmonella typhimu ...	1978	367006
[analysis of penicillin and ampicillin resistance in bacteria i. resistance and beta-lactamase production in clinical isolates (author's transl)].	the penicillin beta-lactamase (pbl) activity of the clinical isolates was measured at the same time by colorimetric microtitration, the iodometric method and chromatographic analysis. the minimal inhibitory concentration (mic) of ampicillin (ap) was determined for each isolate, the character of the coupled resistances, their frequency and distribution in the pbl producing and pbl-negative strains were also investigated. it was found that 1. the mic value was 100 microgram/ml in 87.5 per cent of ...	1978	366997
pyogenic arthritis and rheumatoid disease: the importance of the infected foot.	during a nine-year period (1968--76) 75 patients were admitted to coventry hospitals becaues of pyogenic arthritis. of these patients, 22 suffered from pre-existing rheumatoid disease, and in these the foot was the most common site of primary infection. adequate and energetic management of foot problems and associated skin sepsis in patients suffering from rheumatoid disease appears to offer the best opportunity of reducing the incidence of superimposed pyogenic arthritis.	1978	366718
urinary tract infection in general practice.	in three studies, 616 patients (610 female and six male) presented with symptoms suggesting urinary tract infection (uti). of these, 321 had greater than 100 x 10(6) bacteria per litre in a midstream urine sample. none of the presenting symptoms could be considered to be a reliable indicator of bacteriuria. ninety percent of infected urines and 44 percent of uninfected urines had a raised white cell concentration. escherichia coli was the most common infecting organism (71.3 percent). next were ...	1978	366474
extension of a chromosome linkage group of proteus mirabilis.	mating procedures for detection of mobilization of the proteus mirabilis chromosome were re-investigated. the chromosome was mobilized by plasmid d, the previously used hybrid between plasmids p-lac and r1drd19. about a 40-fold increase in recombinant recovery correlated with the absence of swarming during mating and a lower temperature of incubation. the modification introduced was that conjugation was allowed to proceed on a non-selective supplemented minimal medium at 30 degrees c before wash ...	1978	366071
secondary bacterial infection in bilharzial urological patients with special reference to the effect of tartar emetic on the causative micro-organisms.		1977	366058
recurrences in primarily infected and uninfected urolithiasis.	an analysis was carried out of 640 patients treated because of urolithiasis at the urological clinic of the medical academy in warsaw in the years 1971--1974. factors conducive to stone formation were analyzed. in infected urolithiasis, different bacterial floras were found in men and women. the importance of infections acquired in hospital by patients is emphasized. in primarily uninfected urolithiasis there were 35 per cent recurrences, as against 53 per cent recurrences in infected urolithias ...	1978	365823
[comparative susceptibility testing to sulfamethoxazole and trimethoprim by agar diffusion test on different media (author's transl)].	14 lots of 6 different commercial media for susceptibility testing were compared by agar diffusion test with 161 bacterial strains. the result "resistant" to sulfamethoxazole, trimethoprim, or co-trimoxazole varied in wide limits between the media. the lot employed by the "work-group on resistance" of the paul ehrlich society is of limited value for testing of the investigated drugs.	1978	365716
gram negative bone and joint infection: sixty patients treated with amikacin.	sixty patients with bone and joint infections secondary to gram negative infection were evaluated in relation to treatment with amikacin. forty-seven of these patients had osteomyelitis, and 13 had joint infections, including 3 prosthetic replacements. the patients' average was 35 years and there was no predilection for any particular skeletal location. only 6 patients had no associated predisposing medical problems. of these problems fracture, diabetes and narcotic abuse were most common. thirt ...	1978	365414
simultaneous production of two types of beta-lactamase in escherichia coli and providencia stuartii.	the production of beta-lactamase has been studied in two strains isolated from clinical samples: providencia stuartii mulb 501 and escherichia coli mulb 130. these strains were selected for their high resistance level to penicillins and cephalosporins. determination and identification of beta-lactamase activity were achieved by combining several up-to-date methods including (i) neutralization by anti-beta-lactamase sera, (ii) purification by affinity chromatography on cephalosporin c linked seph ...	1978	365308
effect of triton x100 on the oxidation of l-phenylalanine by membranes of proteus mirabilis.		1978	365248
new cephamycin antibiotic, cs-1170: binding affinity to penicillin-binding proteins and inhibition of peptidoglycan cross-linking reactions in escherichia coli.	the binding activity of cs-1170, a new cephamycin antibiotic, to penicillin-binding proteins (pbps) in escherichia coli and proteus species and the potency of this antibiotic in vitro to inhibit enzymes involved in peptidoglycan cross-linking in e. coli were tested. similar experiments were carried out with the 7alpha-h analog of cs-1170, r-45656, and the results were compared with those obtained with cs-1170. cs-1170 showed high affinities (compared with that of penicillin g) for e. coli pbp-1a ...	1978	365089
identification of proteus morganii and distinction from other proteus species.	the identification of proteus morganii in the clinical laboratory is complicated by the differences in incidence of hydrogen sulfide (h2s) production recorded by different sources. since this quality appeared to be a frequent feature of strains of p. morganii at the author's center, all isolates of this species were studied over a six-month period. during this time, 12 of 21 were found to produce scant h2s in kligler's iron agar (kia) and triple-sugar iron (tsi) agar butts. the strains were, in ...	1978	364977
[lysogeny in bacteria of the genus proteus and use of moderate phages for direct typing].		1978	364892
[elimination of multiple drug resistance of intestinal bacteria in white mice in vivo with proflavine and rimactan].	albino mice, infected with 0.4 cu. cm of 10(10) microbial cells (s. heidelberg), were treated with proflavin (0.4 cu. cm of a 0.3% solution) and rimactan rifamycin sv (0.4 cu. cm of a 0.4% solution). proflavin was given singly and four times, daily, in the course of four days, and rimactan was applied four times. given in a single dose proflavin was found to prolong twice as long the life span of albino mice infected with s. heidelberg. when injected four times it lowered considerably the mortal ...	1978	364820
diseases of the respiratory system in reptiles.		1978	364816
[antibiotic policy and bacterial resistance].		1978	364322
a hydroxamic acid from aspergillus nidulans with antibiotic activity against proteus species.	an iron-complexing antibiotic with a narrow spectrum of biological activity was produced by several strains of aspergillus nidulans when grown in a low-iron, chemically defined medium. its chemical and biological properties closely resembled those of desferritriacetylfusigen, a metabolite of several other aspergilli and penicillia.	1978	363670
an overview of results of world-wide clinical trials with cefadroxil.	céfadroxil, a new semisynthetic oral cephalosporin, is absorbed similarly by fasted and non-fasted subjects, produces sustained serum levels and is eliminated at a relatively slow rate. these pharmacokinetic properties permit less frequent and more convenient dosage scheduling than cephalexin and cephradine and consequently greater patient compliance. cefadroxil was evaluated for safety in 1051 patients and for efficacy in 1030 patients. overall it achieved a 91.8% rate of clinical success resul ...	1978	363481
bacteriuria in urinary schistosomiasis in egypt a prevalence survey.	an epidemiologic survey to assess the prevalence of bacteriuria in urinary schistosomiasis was carried out in a region endemic for urinary schistosomiasis in egypt. twenty of 390 (5.1%) school boys aged 5--16 years were bacteriuric. this prevalence rate is more than 10 times greater than that found in comparable surveys in areas non-endemic for urinary schistosomiasis. in this endemic population bacteriuria was found in 6.5% of active egg excreters and 2.3% of non-egg excreters.	1978	362956
[identification of enterobacteriaceae species in clinical-microbiological laboratories].		1978	362750
fermentation, isolation, and biological activity of maduramycin: a new antibiotic from actinomadura rubra.	in a continuing search for new antibiotics, the species actinomadura rubra (sveshnikova et al.) j. meyer et m. sveshnikova 1974 (strain imet 13001) was found to produce a red pigment with indicator properties, designated maduramycin. the pigment (c28h22o10; m.w. 518 m/e-; m.p. 305--310 degrees c (dec.); uvmax 225.307 nm) possesses a strong antimicrobial activity against gram-positive bacteria, including strains which produce inactivating enzymes for some commercial antibiotics. maduramycin forms ...	1978	362738
the significance of serum-sensitive bacilli in gram-negative bacteremia.	clinical findings from 76 patients (median age 67 years) with gram-negative bacteremia were analysed and related to the sensitivity of the blood isolates to the bactericidal activity of normal human serum. 28 strains (37%) were resistant, an equal number intermediately sensitive and 20 markedly sensitive (26%). no correlation was found between serum sensitivity and origin of the bacteremia, presence of fever or blood granulocyte count. the frequency of shock in immunocompromised patients with se ...	1978	362514
initial urinary tract infection caused by proteus mirabilis in infancy and childhood.		1978	361938
influence of pili on the virulence of proteus mirabilis in experimental hematogenous pyelonephritis.	the ability of heavily and lightly piliated proteus mirabilis to infect the renal parenchyma was compared in a model of hematogenous pyelonephritis. cortical abscesses occurred in 13 of 24 rats injected with lightly piliated p. mirabilis but in none of 24 rats challenged with heavily piliated organisms (p less than 0.001). lightly and heavily piliated organisms were cleared from the vasculature equally rapidly and were also delivered to the kidney in equal numbers. during the first 24 hr, howeve ...	1978	361900
quantation by flow microfluorometry of total cellular dna in acanthamoeba.	the dna content of five species of acanthamoeba was determined by flow microfluorometry. acanthamoeba castellanii (ac-30), acanthamoeba polyphaga (apg and p-23), acanthamoeba rhysodes, acanthamoeba culbertsoni (a-1), and acanthamoeba royreba were grown in a casitone based medium 24-48 hr. the trophozoites were harvested, and evaluated for dna-bound fluorescence. all species tested has dna values between 2.0-5.0 pg/cell. these results placed dna/cell values of acanthamoeba slightly lower than dna ...	1978	361883
inhibition of protein synthesis by three erythromycin-derivatives.		1978	361037
nature of the swarming phenomenon in proteus.		1978	360961
[new aspects of the value of endotoxins in various gastrointestinal diseases].	recent investigations of several authors on portal venous and systemic endotoxemia in healthy adults have shown that endotoxins absorbed from the intestinal mucosa are found in portal venous blood, cleared by the res of the liver and usually cannot be determined in peripheral blood. in patients with liver disease, however, there was often a reduced endotoxin clearance with spillover of endotoxin resulting in systemic endotoxemia. among the complications of systemic endotoxemia, hepatocytotoxicit ...	1978	359442
a comparison of the minimum inhibitory concentrations of sisomicin and of fourteen other antibiotics.	the activities of sisomicin and of fourteen other antibiotics have been compared for their inhibitory activity on all the different strains of bacteria isolated from a 3,000 bed hospital. the antibiotic sensitivity tests were performed in liquid medium and expressed as minimum inhibitory concentrations. the tests were performed over a period of four months. the results are discussed.	1978	359385
[chemotherapy of experimental lactational mastitis in mice].	more severe mastitis on infection with proteus was shown on a standardized model of experimental lactation mastitis of mice caused by staphylococcus, proteus and their mixture. significant differences in the morphological pictures of the staphylococcal and proteus mastitis were noted. a pronounced effect was observed with the use of kanamycin in combination with fuzidin in treatment of experimental mastitis of various etiology.	1978	358913
[antibiotic sensitivity of the h- and o-forms of bacteria in the genus proteus].	proteus strains isolated from the gastro-intestinal tract of children not older than 1 year were characterized by resistance to oxytetracycline, chlortetracycline, benzylpenicillin and erythromycin. the strains were more sensitive to neomycin, monomycin and streptomycin. antibiotic sensitivity of pr. mirabilis and pr. vulgaris strains increased on transfer from h- to o-form. inverse dependence of the urease activity of the strains on their sensitivity to tetracyclines was noted.	1978	358911
analysis of amines and other bacterial products by head-space gas chromatography.	a gas chromatographic (gc) head-space technique is presented, which is suitable for the analysis of volatile products in bacterial broth cultures. this is exemplified by studies on clostridium septicum, klebsiella pneumoniae and proteus mirabilis. the media were acidified or made alkaline and after heating, samples of the gas phase above the media were directly injected into the gas chromatograph. a gas chromatograph equipped with dual columns and flame ionization detectors was used, employing p ...	1978	358746
urinary tract infections caused by proteus mirabilis in children. the antibody response to o and h antigens and tamm-horsfall protein and bacterial adherence to uro-epithelium.	sera from seven girls with acute symptomatic pyelonephritis and nine children with acute symptomatic cystitis caused by proteus mirabilis were analysed for antibodies against the bacterial o and h1 antigens and the tamm-horsfall protein. an increase in antibody levels against o antigen and tamm-horsfall protein was noted only in patients with acute pyelonephritis indicating that antibody determinations can be useful in differentiating between upper and lower urinary tract infection caused by pro ...	1978	358736