Publications

[transition of dna with r factor nr84].		1975	765551
sources of variance in the measurement of intrapulmonary killing of bacteria.	sources of variability are described for a method used for the quantitative measurement of pulmonary resistance to inhaled bacteria in individual animals. factors contributing significantly to variability include aerosol exposure chamber design, bacterial species used for aerosol challenge, location of animals in the chamber, and individual intrapulmonary bacterial killing rates. laboratory error accounted for a small portion of the variance. the data demonstrate that with appropriate modificati ...	1976	765417
bacteriocine typing of proteus.	a method of typing isolates of proteus mirabilis and proteus vulgaris is described based on the sensitivity of the organisms to bacteriocine. twelve standard proteocine producing strains were selected from a large number of isolates tested, and from these liquid proteocine preparations were prepared. the sensitivities of 1805 isolates to these 12 preparations were then determined and none was found to be untypable. from the results a bacteriocine typing system has been developed.	1975	765360
[enzymatic quick determination of aminoglycoside antibiotics in serum].	the therapeutic range of aminoglycoside antibiotics is relatively narrow; therefore short-term controls of serum concentrations can be recommended, particularly for high-dosage therapy and for renal insufficiency. for the aminoglycosides amicacin, gentamycin, sisomicin and tobramycin an enzymatic quick-determination test within 2 hrs is being described, which is based on the ph-deviation of a medium containing urea by hydrolytic activity of proteus mirabilis-bacteriae. in more than 180 measureme ...	1976	765289
growth and electron microscopic studies on an experimentally established bacterial endosymbiosis in amoebae.	a strain of nonsymbiotic a. proteus was infected with endosymbiotic bacteria isolated from another strain of amoeba which had become dependent on the symbionts after a few years of spontaneously established symbiosis. in the newly infected amoebae, the bacteria avoided digestion and multiplied at a faster rate than the hosts, reaching the maximum carrying number (about 42,000 per amoeba) in fewer than ten cell generations of the hosts. the experimentally infected amoebae were also examined under ...	1979	762201
meso-alpha,epsilon-diaminopimelate d-dehydrogenase: distribution and the reaction product.	a high activity of meso-alpha-epsilon-diaminopimelate dehydrogenase was found in extracts of bacillus sphaericus, brevibacterium sp., corynebacterium glutamicum, and proteus vulgaris among bacteria tested. b. sphaericus ifo 3525, in which the enzyme is most abundant, was chosen to study the enzyme reaction. the enzyme was not induced by the addition of meso-alpha-epsilon-diaminopimelate to the growth medium. the reaction product was isolated and identified as alpha-amino-epsilon-ketopimelate by ...	1979	762012
bacteriology of chronic otitis media.	tympanocentesis was performed in 50 patients with chronic otitis media; pus was cultured aerobically and anaerobically. only aerobes were isolated from 21 patients (42%), three patients had only anaerobes (peptococcus sp), and 25 patients (50%) had both aerobes and anaerobes. only one specimen had no growth. there were 68 aerobic isolates. pseudomonas aeruginosa was recovered in 36 patients (72%); other aerobes commonly recovered included proteus sp and staphylococcus aureus. there were 48 anaer ...	1979	759663
peculiarities of changes in dna content of amoeba proteus nuclei during interphase. a cytofluorometric study.		1979	759212
[aspecific agglutinations by omnivalent anti-salmonella sera. cross-reactions with "proteus" (author's transl)].		1978	755456
studies of a receptor for fp3-phage in salmonella minnesota r595.	the adsorption rate constant of the phage fp3 to sensitive s. minnesota r595 strain was used to evaluate the inactivating capacity towards phage fp3 exhibited by isolated glycolipid and free lipid a. the results suggest that phage fp3 receptor is localized in the glycolipid structure. phage fp3 is not adsorbed on the other re mutant cells, proteus r45, but respective products: glycolipid and free lipid a from r45 exhibitory the inhibition capacity towards phage fp3, comparable to the activity of ...	1978	749776
oxalate biosynthesis from phenylalanine by the providencia-proteus group organisms.		1978	747520
[characteristics of the enterobacteria strains isolated from the urine in urinary tract infections].	study of biochemical properties of 421 strains of enterobacteria permitted to refer them to the following taxonomic groups of which e. coli constituted 83,4 +/- 3.6%, enterobactercloacae--97 +/- 3.0%, klebsiella 4.0 +/- 2.0%. enterobacter aerogenes, enterobacter hafnia, citrobacter, proteus rettgeri, proteus vulgaris were revealed in individual cases (0.2-1.0%). as a result of serological typing there were revealed 105 serological types of escherichia differing by 55 o-antigen variants, 26 h-ant ...	1978	747014
[l-asparaginase activity of microorganisms].	l-asparaginase content was studied in 67 different microorganisms, bacterial strains of e. coli, pseudomonas, erwinia, proteus, alcaligenes, bacillus, bacteria. xanthomonas, and yeasts and fungi-saccharomyces, candida, aspergillus, epidermophyton, trichophyton. all the bacterial strains studied possessed l-asparaginase activity, which varied greatly depending on the representative (10-1200 iu/g dry weight of cells). yeasts and fungi displayed low l-asparaginase activity.	1978	747012
[r factors in proteus rettgeri strains].		1978	742932
[case studies of bacterial species responsible for urinary tract infections and their sensitivity to antibiotic treatment].	a microbiological assessment was made of 829 urine specimens to determine the percentage incidence of different bacterial species and their susceptibility to antibiotic treatment. it was found that e. coli was most common, followed by pseudomonas, proteus, staphylococcus, candida, faecal streptococcus, and shigella. the results suggest that the aetiological agent should be systematically ascertained and an antibiogram run before a treatment programme is laid down.	1978	740260
meningoencephalitis secondary to otitis in a gorilla.	an adult female gorilla died following a 13-day illness and was necropsied. gross and microscopic findings included a 2-cm straw deep in the external auditory meatus, suppurative otitis media and interna, and suppurative meningoencephalitis. proteus mirabilis was cultured from the internal acoustic pore.	1978	738932
in vitro activity of oxolinic acid and nalidixic acid against common urinary pathogens: a comparative study.	a study was carried out to compare the sensitivity of 500 bacterial strains, isolated from patients with urinary tract infections, to oxolinic acid and nalidixic acid. the results showed that whilst both antibacterial agents were similar in their bacterial spectrum they were not identical in terms of cross-sensitivity or resistance. where there was a difference in sensitivity, this was always in flavour of oxolinic acid and was particularly evident in the case of staphylococcus, pseudomonas, ser ...	1978	738079
[investigations on the antimicrobial activity of amin-aldehyde-condensates. 5. communication: azomethins of benzaldehyde (author's transl)].	in the scope of our research about the antimicrobial activity of amin-aldehyde-condensates a number of benzylidene-amines (azomethins of benzyldehyde) was synthesized by condensation of primary amines with benzaldehyde. structures and physical constants are shown in table 1 and 2. the antimicrobial activity of these benzylidene-amines is demonstrated by the results of the disk-test (table 3), of the minimal inhibition concentration test (mic, table 4) and the suspension test (table 5) following ...	1978	735566
[investigations on the antimicrobial activity of amin-aldehydecondensates. 4. communication: azomethins of aliphatic aldehydes (author's transl)].	in the scope of our research about the antimicrobial activity of amin-aldehyde-condensates a number of azomethins was synthesized by the condensation of primary aliphatic and aromatic amins with aliphatic aldehydes. structures and physical constants are listed in table 1 and 2. - the antimicrobial activity of these azomethins is demonstrated by the results of the disk-test (table 3), of the minimal inhibition concentration test (mic, table 4), and the suspension test (table 5) following the meth ...	1978	735565
r plasmids coding for supra-levels of gentamicin, tobramycin and sisomicin resistance in proteus morganii and p. mirabilis: high-level resistant strains from two hospitals.	transfer of high-level gentamycin-tobramycin-sisomycin resistance could be easily demonstrated in strains of p. morganii and p. mirabilis which emerged, in two hospitals, at the end of 1976. first such strains were demonstrated in a patient of a urological ward who died, in september 1976, from generalised sepsis caused by a high-level gentamycin-tobramycin-sisomycin-resistant p. morganii. since that event, at least nine such strains were isolated in 1976, and the presence of transferable resist ...	1978	735560
relative importance of enterotoxigenic and invasive enteropathogenic bacteria in infantile diarrhoea.	swedish children and adults (648 patients) with acute diarrhoea were investigated for enterotoxigenic strains in stool cultures. a total number 74 strains were isolated from 28 patients and assayed in the rabbit intestinal loop test and the adrenal cell test. only three of the enterotoxigenic e. coli (etec) isolates belonged to classical enteropathogenic serotypes of e. coli (epec). two enterotoxigenic strains of proteus morganii, two of enterobacter hafniae and one of citrobacter freundii were ...	1978	735553
diaminobenzidine reactions in control and treated amoeba proteus.	cytochrome oxidase activity was demonstrated in amoeba proteus by diaminobenzidine (dab) cytochemistry. deposition of the reaction product occurred on the inner mitochondrial membranes and the cristae. the reaction was abolished by cyanide incubations. positive reactions were produced with both unfixed and fixed cells: although staining potential was destroyed by any prefixatives which included glutaraldehyde. cells prefixed with 4% formaldehyde, to raise structural preservation, retained staini ...	1978	730555
proteocine types in relation to their source of isolation and antibiogram.		1978	730245
[growth of some pathogenic microorganisms on chemically defined media which were proposed for sensitivity testing (author's transl)].	the growth of 16 bacterial cultures, which belong to the frequently encountered pathogens, in three different chemically defined fluid media was investigated through turbidity measurements in comparison with mueller-hinton-broth. e. coli, salm. dublin, salm. typhi-murium, enterobacter cloacae, proteus mirabilis, pseud. aeruginosa and bac. cereus grew in two of the three tested defined media with approximately the same intensity as in the mueller-hinton broth. staph. aureus grew well only in one ...	1978	730218
skeletal muscle involvement in rocky mountain spotted fever.	a case of rocky mountain spotted fever in a 10-year-old boy accompanied by an unusually high degree of myalgia and muscle weakness was presented. on admission to the hospital, his creatine phosphokinase, sgot, sgpt, and aldolase values were all abnormally high. rash did not appear until the fourth hospital day. on the same day results of a proteus ox-19 titer of blood were reported as positive (titer 1:320) and intravenous therapy with chloramphenicol was started. the child's condition gradually ...	1978	725640
bacterial infections, sensitivity patterns, and chemotherapy among hospital patients in the tropics.	a prospective clinical and bacteriological review of the pattern of bacterial infections and chemotherapy among 1931 patients admitted to university college hospital, ibadan, between july and september, 1976, showed that 394 patients (20%) had bacterial infections, but 940 patients (49%) received antimicrobial chemotherapy. thus 58% of the patients were treated either prophylactically or without bacteriological confirmation of infection. infections of the respiratory tract were commonest (28%), ...	1978	725540
[antibiotic prophylaxis in intensive care].	of 611 prospectively studied patients in a surgical intensive care unit, 177 developed hospital infections (29%): urinary tract infections (37.2%), pneumonia (22.5%), sepsis (19.7%), wound infections (9.6%), etc. the commonest pathogens were pseud. aeruginosa, e. coli, staph. aureus, enterococci, klebsiella pneumoniae and proteus mirabilis. in preventing and combating hospital infections in intensive care units, priority should be given not to antibiotics but to hygiene in the hospital. systemic ...	1978	721586
the effect of lipid a on the fluidity and permeability properties of phospholipid dispersions.		1978	720592
microbiology of deep tissue in diabetic gangrene.	information on the incidence and nature of the causative organisms in the infected tissues of patients with diabetic gangrene is scanty. studies in which material for culture was obtained from the presenting lesion reveal multiple organisms in host isolates. no data are available regarding the bacterial flora of the deep infected tissue itself, uncontaminated by surface organisms. in this investigation 58 specimens from 52 patients were obtained utilizing aerobic and anaerobic culture techniques ...	1978	720182
ticarcillin disodium in anaerobic infections.	twenty-five patients were treated with ticarcillin disodium, 18 of whom had anaerobic infections that included pleuropulmonary infections (seven), mandibular osteomyelitis (four), perirectal abscess (two), sepsis, primary site unknown (one), liver abscess (one), pelvic abscess (one), decubitus ulcer (one), and synergistic gangrene (one). seven had no anaerobic infections. three had anaerobic septicemia. culture results included anaerobes: peptococci (ten), peptostreptococci (ten), bacteroides fr ...	1978	718311
sce-963, a new broad-spectrum cephalosporin: in vitro and in vivo antibacterial activities.	sce-963 {7beta-[2-(2-aminothiazol-4-yl)acetamido]-3-[({1-(2-dimethylaminoethyl)- 1h-tetrazol-5-yl}thio)methyl]-ceph-3-em-4-carboxylic acid}, a new semisynthetic cephalosporin, showed excellent antibacterial activity against gram-positive and gram-negative bacteria, including haemophilus influenzae, indole-positive proteus, enterobacter species, and citrobacter freundii. the minimum inhibitory concentrations of sce-963 against most strains of clinically isolated escherichia coli, klebsiella pneum ...	1978	718154
[effect of treatment on the dynamics of immuno-microbiological indicators in chronic enterocolitis].		1978	716342
[evaluation of efficacy of the use of coli-proteus bacteriophage in intestinal dysbacteriosis in premature infants].		1978	716289
urinary tract infection in high-risk newborn infants.	the prevalence of neonatal urinary tract infection (uti) was studied in 1,762 high-risk neonates. symptomatic bacteriuria was found in 1.9% and asymptomatic bacteriuria in 0.5% of these neonates. male preponderance was 5:1. clinical manifestations were extremely variable--vomiting, weight loss, and diarrhea being the prominent symptoms. bacteremia was associated with uti in six infants. the organisms identified in the urine obtained by suprapubic aspiration were escherichia coli, klebsiella, and ...	1978	714582
drug resistance studies with topical antiseptics.	species of proteus, serratia, and pseudomonas became resistant to chlorhexidine after five to eight transfers in vitro. cross-resistance to benzalkonium chloride also was detected. resistance to povidone-iodine was not encountered. chlorhexidine resistance was stable after drug-free transfers of serratia and pseudomonas but was transitory for proteus.	1978	712607
hematogenous osteomyelitis: a report of four cases.		1978	712236
gas liquid chromatography for detection of bacteriuria: examination for volatile acidic and neutral compounds.	direct injection of clinically infected urines on porous-polymer columns was investigated to determine which microbial metabolites were consistently detectable, and whether their presence could be used as a reliable index of infection. chromosorb 101 was found to be the most suitable porous polymer for the detection of microbial metabolites; greater sensitivity of detection was achieved by partial purification of the urine before injection. acetic acid was the only compound found consistently an ...	1978	711917
sensitivity of urine-grown cells of providencia stuartii to antiseptics.	urine-grown cultures of 23 clinical isolates of gram-negative bacteria having a range of minimum inhibitory concentration values for chorhexidine were challenged with various concentrations of this antiseptic. the results suggest that cells of providencia stuartii, in particular, exhibit a considerable degree of resistance to chlorhexidine under these conditions, concentrations of up to 10 000--20 000 microgram/ml of urine being necessary to produce complete loss of viability of such cultures. o ...	1978	711901
cephamycin derivatives: comparison of the in vitro and in vivo antibacterial activities of sq 14,359, cs-1170, and cefoxitin.	sq 14,359 is a new cephamycin-type (7alpha-och3) antibiotic belonging to a series containing a 7alpha-ureidoacetyl substituent. the compound is the most potent extended spectrum derivative of this type yet reported, surpassing cs-1170 and cefoxitin by a wide margin. this activity in vitro which extends throughout the enterobacteriaceae is particularly prominent against gram-negative organisms that are producers of "cephalosporinase-type" beta-lactamases such as enterobacter, serratia, citrobacte ...	1978	711611
the influence of microinjected phalloidin on locomotion, protoplasmic streaming and cytoplasmic organization in amoeba proteus and physarum polycephalum.	microinjected phalloidin induces both time and concentration-dependent changes in morphology and motility of amoebae and acellular slime moulds. in a. proteus injection of a 10(-3)m solution of the drug causes a separation of cortical hyaline plasma from central granular plasma. simultaneously protoplasmic streaming and cellular locomotion are lost irreversibly. lowering the concentration of phalloidin to 2 x 10(-4)m results in a reversible disturbance; amoebae recover after 30 to 60 minutes and ...	1978	710672
identification of the small nuclear rnas associated with the mitotic chromosomes of amoeba proteus.	amebas contain 7 electrophoretically distinct species of small nuclear rnas (snrnas), some of which are known to associate in a striking manner with mitotic chromosomes. these rnas can be divided into 2 classes, one consisting of 4 snrna species that shuttle in a non-random way between nucleus and cytoplasm during interphase and one consisting of 3 snrna species that do not leave the nucleus at all during interphase. in the work reported here we sought to determine which class is associated with ...	1978	710236
[sensitivity of bacteria of the genus proteus to antibiotics and their combinations].	sensitivity of 99 proteus strains isolated from infants with gastro-intestinal diseases was studied by the method of serial dilutions on the ploskirev's medium with respect to 19 antibiotics and some of their pair combinations. high resistance levels were registered with respect to penicillin and semi-synthetic penicillins, such as oxacillin, methicillin, ampicillin, as well as oleandomycin, erythromycin, lincomycin and oxytetracycline. the minimum inhibitory concentration for most of the strain ...	1978	707998
the use of a laminar airflow isolation system for the treatment of major burns.	a laminar airflow isolation burn ward was designed which would maintain a sterile environment and also allow unrestricted burn care and rehabilitation to be performed. a very low rate of sepsis and sepsis-related complications have been found in the 115 patients treated in the unit. patient cross contamination has been completely controlled under laminar airflow conditions. the incidence of burn colonization and infection by virulent gram-negative organisms, namely pseudomonas, serratia, klebsie ...	1978	707709
fournier's gangrene complicating perinal abscess: report of two cases.	two cases of fournier's gangrene in which toxemia and gangrene of the scrotum developed due to perianal abscesses are described. cultures of anaerobic gram-negative bacteroides with a mixed flora of pseudomonas, e. coli and proteus were obtained. early diagnosis, wide and deep incisions, debridement of the necrotic tissue, and adequate antibiotic therapy can prevent a fatal outcome of this disease. a high mortality rate is still prevalent.	1978	699732
activity of 5-episisomicin compared with that of other aminoglycosides.	5-episisomicin, a semisynthetic aminoglycoside, has been shown to inhibit many members of the enterobacteriaceae, pseudomonas aeruginosa, and staphylococcus aureus. at a concentration of 3.1 mug/ml, more than 90% of escherichia coli, klebsiella pneumoniae, enterobacter, citrobacter, indole-positive proteus, and providencia were inhibited. 5-episisomicin had activity against s. aureus, e. coli, klebsiella, enterobacter, and citrobacter similar to gentamicin and netilmicin. it had activity similar ...	1978	697347
in vitro studies with sch 21420 and sch 22591: activity in comparison with six other aminoglycosides and synergy with penicillin against enterococci.	in vitro tests were performed with sch 21420 and sch 22591 to determine (i) their activity in comparison to six other aminoglycosides against 343 clinical isolates, and (ii) whether synergy with penicillin g could be demonstrated with enterococci. in broth dilution tests, sch 22591 was more active than the seven other aminoglycosides against staphylococcus aureus, enterobacteriaceae, and most nonfermenting gram-negative bacilli. sch 22591 was as active as tobramycin against pseudomonas aeruginos ...	1978	697346
[hospital acquired infections in children (author's transl)].	the incidence of hospital-accquired infections in children as given in the literature varies between 0.3%--25%. the most frequent infections are those of the urinary tract, respiratory tract, skin, wounds, gastrointestinal tract, or septicemia, and meningitis, caused by staphylococcus aureus, e. coli, klebsiella, enterobacter, pseudomonas, proteus, fungi or virus. besides the identification of the type of infectious agent it is most important for the prevention and therapy of hospital-acquired i ...	1978	692524
response to light-shade difference in anucleate and polynucleate specimens of amoeba proteus.	the enucleated specimens of amoeba proteus, the anucleate fragments, and the polynucleate individuals which all are capable of cortical contraction but not of locomotion, may be reactivated by the light-shade difference established across their body. individual cells or fragments migrate toward the shade. the motory polarity and coordinated movement disappear immediately after cessation of the stimulus. the results are interpreted according to the earlier hypothesis that the necessary to maintai ...	1978	689261
ultrastructure of the frontal cap of monotactic forms of amoeba proteus.	the frontal cap of the monotactic form of amoeba proteus is separated from other cell components by a continuous structure defined as the "membrane-like envelope" (mle). it originates from the membranes of cytoplasmic vesicles and vacuoles. the border zone between the cap and the cytoplasm is strongly vacuolized. structural differences between frontal caps, depending on the degree of their development, indicate that the growing cap gradually fills up the whole tip of an advancing pseudopodium, a ...	1978	689256
fine structure of cytoplasmic crystal in amoeba proteus.		1978	689254
cytoplasmic streaming in amoeba proteus is inhibited by the actin-specific drug phalloidin.		1978	689103
[the phagocytic reaction in amoeba proteus. ii. phagocytosis of non-living particles].		1978	688109
in vitro activity and beta-lactamase stability of bl-s786 compared with those of other cephalosporins.	in vitro activity of bl-s786, a new parenterally semisynthetic cephalosporin, was investigated against 570 bacterial isolates. bl-s786 inhibited most escherichia coli, klebsiella pneumoniae, proteus mirabilis, and salmonella. it inhibited some enterobacter and indole-positive proteus, but it was less active against these later species than was cefamandole, cefuroxime, or cefoxitin. it was not active against serratia marcescens, pseudomonas aeruginosa, or bacteroides fragilis. bl-s786 was the lea ...	1978	686701
[pharmacokinetic investigations on sisomicin in children (author's transl)].	sisomicin is an aminoglycoside effective against gramnegative germs. the sensitiveness of coli, proteus, pseudomonas and klebsiella ranges from 0,1 to 0,4 mcg/ml. germs with inhibition-values of up to 1 mcg/ml are certainly sisomicin-sensitive. the side-effects of sisomicin resemble those of other aminoglycosides, as for instance lesions of the viith cranial nerve and the kidney. since aminoglycosides have a relatively small therapeutic range between toxicity and effective minimal-concentration, ...	1978	683201
proteus contaminates liquifilm tears.		1978	683111
differences between nucleus and cytoplasm in the degree of actin polymerization.	for purposes of studying the degree of polymerization of actin in nuclei, nuclei from 35s-labeled amoebas (amoeba proteus) were transplanted into unlabeled cells, which were immediately lysed and extracted under conditions considered to stabilize preexisting fibrous actin. the enucleated 35s-donor cells were similarly treated for analysis of cytoplasmic actin. the extraction conditions permitted separation of soluble (unpolymerized or g) actin from pelletable (polymerized or f) actin, and the ra ...	1978	681454
chemical transformation of gentamicin c1a into 2'-n-methylgentamicin c1a, active against providencia 164.		1978	681243
azlocillin and mezlocillin: new ureido penicillins.	the activity of azlocillin and mezlocillin, new semisynthetic ureido penicillins, was investigated and compared with that of other known beta-lactam antibiotics. at a concentration of 25 mug/ml, azlocillin inhibited 74% of enterobacter, 97% of proteus mirabilis, 64% of citrobacter, 91% of pseudomonas aeruginosa, and 82% of bacteroides strains tested. mezlocillin inhibited 86% of shigella, 96% of enterobacter, 80% of indole-positive proteus, 88% of bacteroides, and 63% of pseudomonas strains test ...	1978	677860
surveillance of gentamicin-resistant gram-negative bacilli in a general hospital.	aerobic gram-negative bacilli isolated from clinical specimens from 1 january to 31 december 1976 were tested for gentamicin and tobramycin resistance by standardized disk testing. for pseudomonas isolates, gentamicin resistance was 17.1% and tobramycin resistance was 2.8%. for other gram-negative bacilli, gentamicin resistance was 5.5% and tobramycin resistance was 5.4%. seventy-four patients from whom gentamicin-resistant organisms were isolated from 1 january to 30 june 1976 were studied pros ...	1978	677859
function of phagocytosis and intracellular killing of peripheral neutrophils in kawasaki disease.	nbt (nitroblue tetrazolium) test was performed in 17 patients with kawasaki disease to examine the function of phagocytosis and intra-cellular killing of neutrophils. the value was high compared to other pediatric patients. activation with proteus ox-2 antigen before nbf test showed a significant higher level than other proteus antigens, which correspond in serum level. with previous electronmicroscopic observation of rickettsia-like body in biopsy specimen, these findings suggest the existence ...	1978	676746
nitrosamine formation in bladder infections and its role in the etiology of bladder cancer.	dimethylnitrosamine, a powerful carcinogen, is produced in the urine of patients with urinary tract infections of proteus mirabilis and escherichia coli when nitrite is present. treatment with tetracycline antibiotics does not enhance the concentration of this carcinogen but, rather, sharply reduces it. the results emphasize the importance of proper antibiotic therapy for the infections to reduce the possibility of the subsequent development of bladder cancer.	1978	671604
kanamycin resistance in providencia stuartii.		1978	670120
glycocinnamoylspermidines, a new class of antibiotics. v. antibacterial evaluation of the isopropyl derivative of ll-bm123gamma.	isopropyl ll-bm123gamma, a novel semisynthetic glycocinnamoylspermidine antibiotic, was active in vitro against both gram-negative and gram-positive bacteria with broad spectrum bactericidal activity against clinically important gram-negative strains. in parallel tests, it was equal to or more potent than reference aminoglycoside antibiotics against escherichia coli, proteus, enterobacter-klebsiella, serratia, salmonella, and acinetobacter strains. against clinical isolates of pseudomonas aerugi ...	1978	670083
cross-protection of mice provided by active and passive immunization against experimental infections with virulent proteus rettgeri and providencia bacteria.	immunization with providencia and proteus rettgeri formalin-treated bacterial suspensions produced high levels of protection in mice against homologous and heterologous challenge. mice were also cross-protected, but less effectively, by passive administration of rabbit type-specific antisera. the protective activity appeared to be due to an antigen common to strains of different o-serotypes. it was not detectable in agglutination reactions, and preliminary results indicate that it is thermostabl ...	1978	669801
[microbiological evaluation of cefoxitin, a new beta-lactamase resistant cephamycin antibiotic, compared to cephalothin, cephaloridine and cefazolin].	cefoxitin (mefoxitin), cephaloridin, cephalothin and cefazolin were tested in vitro against 380 clinical isolates of staph. aureus and enterobacteriaceae using the tube dilution procedure. of the gramnegative microorganisms a selection of 150 strains was examined regarding susceptibility to the antibiotic combinations cefoxitin/gentamicin and cefoxitin/sisomicin in comparison to cephalothin/gentamicin and cephalothin/sisomicin. cefoxitin has a broad antimicrobial spectrum and a high beta-lactama ...	1978	669547
pharmacology and efficacy of netilmicin.	twenty-six patients, 20 to 77 years of age, were treated with netilmicin, mean dose 2 mg/kg every 8 h intramuscularly or in a 20-min intravenous infusion. the mean serum half-lives in patients with creatinine clearances of >/=90 ml/min and 60 to 90 ml/min were 3.2 and 3.4 h, respectively. in patients with serum creatinines of </=1.4 mg/100 ml and creatinine clearances of >/=60 ml/min, mean serum levels were 9.0 and 1.2 mug/ml, respectively, 5 to 15 min and 7.5 h post-intravenous infusion, and 7. ...	1978	666303
synergy of azlocillin and mezlocillin combined with aminoglycoside antibiotics and cephalosporins.	synergistic activity between both azlocillin and mezlocillin and aminoglycosides or cefazolin could be demonstrated by checkerboard dilution, isobologram, and killing curve techniques. azlocillin and mezlocillin combined with gentamicin, netilmicin, or amikacin were synergistic against escherichia coli, klebsiella, citrobacter, enterobacter, serratia, and indole-positive proteus. synergy was observed with isolates that were susceptible or resistant to azlocillin or mezlocillin. synergy was seen ...	1978	666302
cetocycline, tetracycline analog: in vitro studies of antimicrobial activity, serum binding, lipid solubility, and uptake by bacteria.	cetocycline (formerly chelocardin or cetotetrine) is structurally related to the tetracyclines. it was found to be more active than tetracycline against many clinical isolates of aerobic gram-negative bacilli, but is less active against staphylococci, and has no activity against pseudomonas. it is bactericidal against susceptible enteric gram-negative bacteria at concentrations two to four times higher than the minimal inhibiting concentrations. the drug is highly lipid soluble; more than 80% is ...	1978	666291
cefaclor: in vitro spectrum of activity and beta-lactamase stability.	the in vitro activity of cefaclor against 556 clinical isolates of gram-positive and gram-negative bacteria was compared with that of other cephalosporins. cefaclor had activity similar to that of cephalexin against gram-positive bacteria. it showed greater activity against haemophilus strains than did cephalexin and inhibited beta-lactamase-producing haemophilus isolates. cefaclor was more active than cephalexin or cephalothin against escherichia coli, salmonella, and shigella isolates but did ...	1978	666290
acute gram-negative bacillary otitis media.		1978	665603
[epidemiological data on acute intestinal diseases accompanied by the discharge of bacteria of the genus proteus].		1978	665048
prevention of postoperative endophthalmitis.	prevention of postoperative endophthalmitis (poe) requires (1) environmental control, (2) tissue control, and (3) anticipation of eyes at special risk of infection. environmental control entails an adequate supply of finely filtered air and absolute sterility of solutions, medications, and objects and materials used during surgery. tissue control involves degerming the skin of the operative field, inhibition of the flora of the lid margins by an antibiotic ointment use preoperatively, and pretre ...	1978	662287
[importance of research on antibacterial substances in the study of bacteriurias].	a study was made of 1050 urine specimens from the nephro-urological and geriatric departments of the malpighi hospital to see how many percent contained antibacterial substances and the incidence of bacteria species. 26.5% contained antibacterial substances. proteus rettgeri was significantly more frequent in specimens containing such substances, whereas staphylococci were significantly more frequent in the remainder.	1978	662157
[the antimicrobial activity of amikacin in comparison with three other aminoglycoside-antibiotics (author's transl)].	we report about the in-vitro-sensitivity tests of 1756 enterobacteriaceae and pseudomonas strains to amikacin, gentamicin, tobramycin and sisomicin. it was established, that amikacin is more effective than gentamicin, tobramycin and sisomicin in case of infections with klebsiella, proteus species, psuedomonas strains and enterobacter. the four aminoglycosides are well active against e. coli. hospital acquired infections with serratia are a domain of amikacin. tobramycin is more effective than ge ...	1978	661734
urinary lithiasis in children. a review of 155 cases.	155 children presenting with lithiasis have been studied. the study confirms other recent analyses: (1) urinary lithiasis in the child is far more frequent than was previously thought. it is not always easy to diagnose because of the limited opacity of the calculi. (2) its secondary nature is shown in 25% of the cases. (3) its cause is still debated in spite of the evident part played by proteus infection. (4) the prognosis is generally favourable.	1978	658068
l-2-hydroxytetradecanoic acid as a constituent of salmonella lipopolysaccharides (lipid a).	l-2-hydroxytetradecanoic acid was recognized as a characteristic, although minor, constituent of the lipid a component of salmonella lipopolysaccharides. the 2-hydroxy fatty acid was present in lipid a as an ester, probably bound to the hydroxyl group of some d-3-hydroxytetradecanoic acid residues. a survey of enterobacterial lipopolysaccharides showed that l-2-hydroxytetradecanoid acid was also present in klebsiella and serratia strains. it was absent, however, from lipopolysaccharides of other ...	1978	658049
comparative in vitro activity of five nitrofurans.	five nitrofurans- nitrofurantoin, nifuratel, nitrofurazone, furazolidone and and sq 18,506--have been tested against 201 microbial strains. escherichia coli, streptococcus faecalis, micrococci and staphylococcus epidermidis were sensitive to all five compounds; furazolidone and sq 18,506 were the most active against these species. klebsiella aerogenes was less sensitive, and proteus spp., providencia stuartii and pseudomonas aeruginosa strains were resistant. nifuratel was inhibitory for some ca ...	1978	657876
use of antibiotics. penicillins.		1978	656872
[early treatment of intraoperative infections based on bacteriological testing (author's transl)].	validity and efficiency of an antibiotic prophylaxis after extensive orthopedic and traumatological procedures are not universally accepted. often the systematic antibiotic prophylaxis is withhold because of considerable disadvantages. a new method is reported, which enables a bactericidal antibiotic therapy based on bacteriological testing of swabs taken during and after surgery. thus the administration of antibiotics is possible long before the clinical manifestation of an infection. immediate ...	1978	655828
bacteriocine typing of providencia isolates.	a method of typing isolates of providencia is described based on the sensitivities of the organisms to bacteriocines. twelve standard bacteriocine producing strains were selected from a large number of isolates tested and from these liquid bacteriocine preparations were obtained. the activities of these preparations on over 300 isolates were determined and from this information a bacteriocine typing system has been developed.	1978	654675
intestinal bacterial flora of the household lizard, gecko gecko.	a total of 114 isolates was recovered from the intestines of 43 househould lizards, gecko gecko. among the important ones were staphylococcus aureus, salmonella typhimurium, pseudomonas aeruginosa, proteus mirabilis and edwardsiella tarda.	1978	653125
interference reflection microscopy of adhesion of amoeba proteus.	a simple method of observing the adhesive behaviour of large cells by means of interference reflection microscope is described, and some observations of monopodial amoeba proteus are presented. amoebae may contact with the substratum at any point along the long axis of the cells. points of contact are usually few, small and temporary. frequently the cell surface within the contact points oscillates, changing the separation distance from the substratum.	1978	650677
cefamandole in the treatment of infections due to enterobacter and indole-positive proteus.	clinical and bacteriologic results are reported for 80 patients treated with 1.5--12 g of cefamandole daily for a variety of infections caused by enterobacter and indole-positive proteus, organisms that have been resistant to most available cephalosporins. of 45 patients with infections due to enterobacter, 41 (91%) had satisfactory clinical responses; 36 were bacteriologic successes, and six cases of complicated urinary tract infections relapsed. of 37 patients with infections due to indole-pos ...	1978	649997
clinical experience with cefamandole for treatment of serious bone and joint infections.	the safety and efficacy of treatment with cefamandole were evaluated in 30 patients (from 18 institutions) with serious bone and joint infections. five of the subjects were children. the antibiotic was given intramuscularly or intravenously in doses ranging from 2 to 12 g daily for five to 44 days. twenty-six of the 30 patients responded satisfactorily. fourteen of the fifteen infections due to staphylococcus aureus were among the successful cases. other pathogens were streptococci, escherichia ...	1978	649996
sisomicin: in vitro activity and pharmacokinetics.	in vitro activity of sisomicin and gentamicin was compared in serial dilution tests for 619 bacterial strains (staphylococcus aureus, e. coli, proteus mirabilis, proteus vulgaris, enterobacter, klebsiella, pseudomonas aeruginosa, salmonella, serratia marcescens). mean mic of sisomicin was lower by one geometrical dilution step compared with gentamicin for pseudomonas, proteus vulgaris, klebsiella, and serratia, while it was almost identical with the other species. resistance (mic greater than 5 ...	1978	649233
[resistance of pyogenic bacteria during a period of five years (author's transl)].	the bacteriological results of 4113 clinical specimens (wound-swabs) were analysed. in 40 per cent of positive findings staphylococcus aureus was isolated, furthermore, in decreasing frequency staphylococcus epidermidis, proteus, escherichia coli, pseudomonas aeruginosa, enterococci and haemolysing streptococci. during this study a considerable quota of the examined strains was observed to show large fluctuation in sensitivity, but more than half of the isolates demonstrated increasing resistanc ...	1978	645263
holographic microscopy of glycerination of amoeba proteus.	the process of glycerination of amoeba proteus was observed under the holographic microscope with coherent noise elimination. it was found that during glycerination redistribution of cell material occurs, and is accompanied by reversible deformation of the cell cortex. the rôle of the cortex in shape maintenance in glycerinated models was demonstrated.	1978	641989
[flora of the purulent foci of patients at an orthopedic traumatology clinic and its sensitivity to antibiotics].	a total of 4664 bacteriological analyses of the wound and purulent discharge from orthopedo-traumatological patients were performed within a 6-year period, i.e. from 1971 to 1976. staphylococci were the dominating microbes of the purulent-inflammatory foci. its part in the monoculture amounted to 64.5--82 per cent. the specific weight of the monocultures of various microbes decreased during the last 3 years, while the number of the microbial associations increased from 11.6 to 25.4 per cent stap ...	1978	637530
hydroxyurea and infected stones.	the formation of struvite stones is closely linked to the enzyme urease produced by certain bacteria found in urine. it has been shown that hydroxamic acids will block the activity of this enzyme. one of these, hydroxyurea, in a morning dose of 500 mg. was used in 21 patients for three months or longer. most were then able to acidify their urine despite persistent urinary infection. after three months, treatment with nitrofurantoin (macrodantin and hydroxyurea (hydrea), 78.6 per cent of patients ...	1978	636134
electron microscopic visualization of transcribed genes in the nucleus of amoeba proteus.		1978	631219
biological and chemotherapeutic studies on three semisynthetic cephamycins.	three semisynthetic cephamycin antibiotics (7alpha-methoxy-cephalosporins), sk&f 73678, sk&f 83088 (cs-1170) and cefoxitin, have been found to possess favorable biological and chemotherapeutic properties. all three cephamycins are active in vitro against strains of staphylococcus aureus and a variety of gram-negative bacilli. beta-lactamase producing organisms including indole-producing proteus spp., enterobacter spp. and serratia strains as well as certain anaerobic bacteria were found to be su ...	1978	627526
identification of an antibiotic-producing bacterium from the human intestinal tract and characterization of its antimicrobial product.	an antibiotic-producing bacterium repeatedly isolated from human feces was characterized by standard bacteriological methods. the bacterium is a gram-positive bacillus possessing morphological and physiological features similar to those of bacillus subtilis, except that it lacks temperature-resistant spore formation and has peritrichous flagella. the cell-free antibiotic produced by the organism in vitro was effective against some gram-negative and gram-positive bacteria and yeast in minimum inh ...	1978	626495
chemotherapeutic evaluation of 5-episisomicin (sch 22591), a new semisynthetic aminoglycoside.	5-episisomicin (sch 22591) is a novel semisynthetic aminoglycoside with a spectrum and potency similar to gentamicin in its activity against susceptible bacterial strains, but with increased potency against pseudomonas, providencia, and proteus rettgeri. it is also more active than tobramycin and amikacin against these last-mentioned species.against resistant strains, sch 22591 is significantly more active than gentamicin or tobramycin. against resistant gram-negative bacteria other than pseudom ...	1978	626490
pc-904, a new semisynthetic penicillin.	sodium 6{d(-)-alpha(4-hydroxyl-1,5 naphthyridine-3-carboxamido)phenylacetamido} penicillanate (pc-904) is a new semisynthetic penicillin with broad-spectrum activity against gram-positive cocci and gram-negative bacilli. at a concentration of 1.56 mug/ml, it inhibited 100% of isolates of proteus mirabilis, 89% of pseudomonas aeruginosa, 67% of escherichia coli, and 45% of enterobacter spp. at a concentration of 12.5 mug/ml, it inhibited 75% of klebsiella spp. and 67% of serratia marcescens. pc-9 ...	1978	626486
consequence of cerulenin-released beta-lactamase in clinical coliforms.	periplasmic beta-lactamase of certain clinical coliforms was released, without affecting cell viability, by perturbation of the outer membrane utilizing the fatty acid-mimicking antibiotic cerulenin. release of such compartmentalized beta-lactamase, at high population density, seems to provide an extra margin of resistance to the organisms against cephaloridine.	1978	626484
antimicrobial activity in vitro of cefaclor, a new oral cephalosporin.	the antimicrobial activity of cefaclor, a new orally administered cephalosporin derivative, was studied in vitro against a variety of gram-positive and gram-negative clinical isolates. both penicillin-resistant and penicillin-susceptible strains of staphylococcus aureus were susceptible to cefaclor, with mean mics of 1.44 and 0.93 microgram/ml, respectively. however, the mbc for penicillin-resistant s. aureus was higher than that for the penicillin-susceptible strains. all strains of streptococc ...	1978	624778
survey of conjunctival flora in dogs with clinical signs of external eye disease.	bacteria were isolated 68% of the time from the conjunctival sacs of 120 dogs with conjunctivitis, blepharitis, dacryocystitis, or corneal ulcerations. coagulase-positive staphylococcus aureus was the most frequently isolated organism (68%); when both eyes were affected, s aureus was recovered from 29% of the dogs; and in dogs with 1 eye affected, s aureus was isolated from 23% of the affected eyes and in 18% of the nonaffected eyes. other organisms recovered from eyes were coagulase-negative st ...	1978	624664
characteristics of the 'life spanning' phenomenon in amoeba proteus. independent nuclear and cytoplasmic ability to impose finite 'life span'.	amoeba proteus given adequate food grows exponentially and clones of amoebae are normally immortal. after periods of food supply restriction to that necessary for maintenance, or food intake restriction by agitation, cells subsequently given a normal growth diet produce clones of finite life span. reciprocal nuclear transfer between maintained and normal cells demonstrated that the nucleus and cytoplasm of maintained cells have acquired the independent ability to impose a finite life span on clo ...	1978	620943
closure of the plasma membrane around microneedle in amoeba proteus. an ultrastructural study.		1978	620690
physical properties of plasmid mor174, which determines bacteriocin production in proteus morganii 174.	plasmid mor174 has a molecular weight of 3.6 x 10(6) and a buoyant density of 1.6994 g/cm3. the covalently closed circular form has a sedimentation coefficient of 22s. these are 30 to 40 plasmid copies per genome equivalent, but growth in chloramphenicol results in amplification of the copy number to 600. in proteus morganii 174, mor174 coexists with a cryptic plasmid of molecular weight 15.8 x 10(6) and a buoyant density of 1.7170 g/cm3.	1978	618846