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[indicator importance of the bacterial genus proteus in assessing the hygienic status of food products]. 19853885570
inhibitory activity of cefpiramide on beta-lactamase.the beta-lactamase stability and inhibitory activity of cefpiramide were investigated. cefpiramide was found to be stable to hydrolysis and inhibited beta-lactamase produced by citrobacter freundii, enterobacter cloacae, morganella morganii, and escherichia coli. kinetic studies showed that cefpiramide is a competitive inhibitor of cephaloridine hydrolysis by e. cloacae beta-lactamase.19853888544
increased minimum inhibitory concentrations with anaerobiasis for tobramycin, gentamicin, and amikacin, compared to latamoxef, piperacillin, chloramphenicol, and clindamycin.minimum inhibitory concentrations (mics) were determined under both routine aerobic and anaerobic conditions for a total of 93 organisms representing nine genera. mics for the aminoglycosides amikacin, gentamicin, and tobramycin were significantly increased under anaerobic conditions. tobramycin was most sensitive to the loss of antimicrobial activity with anaerobiasis. mics for staphylococci were increased by a higher factor than were mics for gram-negative rods, but even within the latter grou ...19853888545
infection surrounding même implants. 19853889953
[low-frequency ultrasonic cavitation in suppurative surgical diseases]. 19853890335
role of imipenem/cilastatin in the treatment of soft tissue infections.imipenem/cilastatin was given to 243 evaluable patients with moderately severe to severe soft tissue infections. cultures prior to therapy yielded staphylococcus aureus (108 isolates), group d and non-group d enterococci (49), group a streptococci (42), other aerobic gram-positive cocci (72), pseudomonas aeruginosa (54), escherichia coli (32), proteus mirabilis (31), enterobacter (21), klebsiella (20), other aerobic gram-negative rods (58), bacteroides fragilis group (16), and other anaerobes (6 ...19853890534
gram-negative bacillary infections. pathogenic and pathophysiologic correlates.gram-negative bacillary infections continue to be extremely important. escherichia coli is the single most frequently encountered pathogen, followed by organisms belonging to the tribe klebsiella-enterobacter-serratia and proteus-providencia. pseudomonas aeruginosa, although it receives considerable (perhaps excessive) attention, is found relatively less frequently, occurring principally in the hospitalized patient who is immunocompromised. many factors, both host and microbial, are responsible ...19853890536
review of the in vitro spectrum of activity of imipenem.imipenem (n-formimidoyl thienamycin, mk0787), a new carbapenem was found to have the widest antimicrobial activity of currently available beta-lactam drugs. enterobacteriaceae had minimal inhibitory concentrations of imipenem of 8.0 micrograms/ml or less for 99.8 percent of clinical isolates. only rare strains of enterobacter species and proteus mirabilis have higher imipenem minimal inhibitory concentration results. hemophilus and neisseria species were inhibited, but minimal inhibitory concent ...19853890537
aminophylline-induced suppression of pulmonary antibacterial defenses.respiratory infections are frequently observed in patients with chronic obstructive pulmonary disease, indicating that host defenses are compromised. antibacterial defenses of the lung against such infections include the alveolar macrophage and polymorphonuclear leukocytes (pmn) that migrate into the lung to provide auxiliary phagocytic defenses. to test the hypothesis that aminophylline acutely impairs pulmonary antibacterial defenses, mice were challenged by aerosol inhalation with staphylococ ...19853890643
in vitro studies on the antibacterial activities of ym-13115, a new broad-spectrum cephalosporin.the in vitro antibacterial activities of ym-13115, a new parenteral cephalosporin, were compared with those of ceftazidime, cefoperazone, and cefsulodin. the compound was highly active against the common members of the enterobacteriaceae and 2 to 256 times more active than cefoperazone. ym-13115 was as active as ceftazidime against citrobacter freundii, proteus vulgaris, and morganella morganii and two to four times more active than ceftazidime against escherichia coli, klebsiella pneumoniae, en ...19853890729
in vitro antibacterial activity of ceftizoxime against gram-negative strains.the in vitro activity of ceftizoxime against 200 clinical isolates of enterobacteria and pseudomonas, was compared with those of other beta-lactam antibiotics such as: cefotaxime, cefoperazone, cefuroxime, and the aminoglycosides gentamicin and amikacin. ceftizoxime inhibited escherichia coli and klebsiella pneumoniae with doses from two to four fold lower than cefotaxime. ceftizoxime and cefotaxime were more active than cefuroxime and cefoperazone against enterobacter spp., and proteus morganii ...19853891115
aztreonam in the therapy of nosocomial infections in patients with impaired host defenses.a clinical trial was carried out to evaluate the effectiveness of treatment with aztreonam in hospital-acquired infections. twenty patients (13 men and 7 women) with impaired host defenses and nosocomial infections were treated with aztreonam at a dosage ranging 4 and 6 g/day i.v. at 8 or 12-hour intervals. average length of therapy was 10.35 +/- 4.61 days. the isolated organisms were as follows: escherichia coli (5), pseudomonas aeruginosa (5), klebsiella pneumoniae (3), enterobacter cloacae (1 ...19853891117
[characteristics of bacteria in the genus proteus isolated from patients with sporadic and group intestinal diseases].the biochemical and biological properties of 148 proteus strains isolated from patients both in sporadic intestinal infections and in a case of group infection in children's hospital was studied. the study revealed that the etiological factor of the group infection was p. mirabilis belonging to rare serovar 48:2. proteus organisms isolated in sporadic infections belonged to a great number of serovars. no relationship between the isolated serovar and the nosological form of the intestinal disease ...19853887813
[serological diagnosis and immunological aspects of proteus infection. v. design and trial of polyvalent antigenic preparations].the main principles of the development of proteus polyvalent antigen and erythrocyte diagnosticum, including the selection of the initial strains according to the clinical importance of their h-antigens and to the variety of their partial factors, the combination of monoantigens to form a polyvalent antigenic preparation with due regard to the potency of each component and the use of the preparation in serological tests in accordance with its summary potency, as well as the simultaneous loading ...19853887814
[evaluation of the dienes phenomenon in proteus typing]. 19853892619
[epidemiological application of a new bacteriocin typing procedure for proteus mirabilis]. 19853892620
problem pathogens in nosocomial infections of urinary tract.although escherichia coli accounts for as many as 50 per cent of nosocomial urinary tract infections, the most problematic of these infections are usually caused by klebsiella, pseudomonas, and proteus. patients in whom infections with these pathogens are most likely to develop are described. empiric antibiotic therapy is discussed as it relates to coverage of potential infecting pathogens. the development of antibiotic resistance is illustrated with specific examples from a cleveland hospital r ...19853892855
[protective activity of a cell-free klebsiella vaccine in infection in mice caused by streptococcus pneumoniae serotypes].the capacity of dried klebsiella cell-free vaccine, obtained from strain no. 204 by the disintegration of microbial mass with hydroxylamine, for protecting mice from pneumococcal infection caused by s. pneumoniae, serotypes 3, 4 and 9n, has been studied. klebsiella vaccine has been found to possess immunostimulating potency with respect to the s. pneumoniae serotypes under study. on day 5 this potency is manifested to a greater extent than 24 hours after immunization. the combination of klebsiel ...19853887815
[comparative effects of netilmicin and 4 other aminoglycosides on 1028 bacterial strains isolated in a hospital milieu].the activity of netilmicin and four other aminoglycosides was studied by a diffusion method against 1 028 bacterial strains isolated in hospital. nearly all the strains of gram-negative bacilli were susceptible to amikacin; with netilmicin, tobramycin, gentamicin and dibekacin the percentages of susceptible strains were smaller, without any statistically significant differences between them. amikacin and netilmicin were the most effective compounds against staphylococci. netilmicin seemed to be ...19853892446
[detection of lipopeptide complexes in lipid fractions of proteus mirabilis].covalently bonded complexes of phospholipids with peptides were detected in the lipid fractions of proteus mirabilis. the lipopeptides were developed with ninhydrin after treating thin-layer chromatograms with h1 or 0.1 n hcl at 100 degrees c for 4 hours. the complexes can be chromatographed in silicic acid unfixed layers using neutral or weakly acidic systems of solvents. the complexes break down in layers fixed with gypsum or treated with diluted alkali solutions. the complexes can contain sev ...19853892242
[lack of specificity of protected distal bronchial samples in the bacteriological diagnosis of nosocomial pneumonia caused by gram negative bacilli].lower respiratory tract secretions (lrs) were sampled during a two year period in patients undergoing mechanical ventilation using a method previously described by matthew et al. only those lrs positive for gram-negative bacilli were reported in this study. the patients were separated in two groups: those with nosocomial pneumonia due to gram-negative bacilli (np+ group) and those without (np- group). the species most often isolated from lrs were: pseudomonas aeruginosa (25%), proteus (20%), esc ...19853893235
necrotizing emphysematous pyelonephritis: a case report.emphysematous pyelonephritis (ep) is comparatively rare in urological practice. from 1898 to the present time only 45 cases have been described. in this report we describe the case of a 43-year old diabetic man, with right ep without obstruction of the urinary tract and with a urinary infection of e. coli. this appears to be rather rare as it is more frequently associated with obstruction of the urinary tract. surgical exploration enabled us to discover a fistula between the kidney and the wall ...19853894253
[sensitivity of proteus mirabilis to drugs in the presence of human blood serum].for rational antibiotic therapy of patients with persisting bacterial infections, the routine determination of antibiotic resistance in the microorganisms may be insufficient. in this case estimation of the total bactericidal activity of the antibacterial drugs and sera against the causative agents is required. it was shown experimentally that in the presence of human blood sera sensitivity of the p. mirabilis strains to benzylpenicillin, ampicillin, gentamicin, kanamycin and cephaloridin increa ...19853893314
chiral products from non-pyridine nucleotide-dependent reductases and methods for nad(p)h regeneration.enoate reductase (ec 1.3.1.31) from a clostridium tyrobutyricum strain catalyses the stereospecific reduction of many different alpha, beta-unsaturated carboxylates, aldehydes and even some ketones. the enzyme accepts electrons from nadh and, 1.5 times faster, from reduced methyl viologen (1,1'-dimethyl-4,4'-bipyridinium). another new type of non-pyridine nucleotide-dependent reductase has an extremely broad substrate specificity for 2-oxo-carboxylates and 2-oxo-dicarboxylates. in crude extracts ...19853893942
trimethoprim and methenamine hippurate. a new theoretical combination for the treatment of urinary tract infections.the antibacterial interaction of methenamine hippurate (mh) and trimethoprim (tmp) was tested in vitro in 3 different media: urine, brain-heart broth and mueller-hinton broth. mh and tmp were found to have a synergistic interaction in chequer-board titration against 11/11 bacteria in urine. low concentrations of mh (1/2 mic) had an additive or synergistic effect with tmp against 14/14 bacteria in brain-heart broth and 20/26 bacteria in mueller-hinton broth. in addition, the growth of bacteria in ...19853895402
[yeasts in leg ulcers].cultures on sabouraud medium from the leg ulcers of 50 patients were obtained: 24% of the lesions were infected by candida species. the risk factors are analyzed. the disappearance of the yeasts after topical treatment does not consistently speed up the healing.19853894083
[problem of infection-related urinary calculi and the effectiveness of its treatment in children]. 19853895146
new beta-lactam antibiotics in granulocytopenic patients. new options and new questions.infectious complications are a frequent cause of morbidity and, at many centers, the major cause of death in patients with cancer. the increased risk and severity of infectious sequelae result from profound alterations in normal host defenses that occur secondary to the underlying malignancy and the treatment thereof. during the last decade, early empiric antibiotic therapy has become standard practice in the initial management of febrile granulocytopenic patients and has contributed significant ...19853895922
[mathematical approach to bacterial identification].the identification of enterobacteriaceae is examined in the context of the recent field of research assisted by multi-criteria decisions. in particular, the authors discuss the limitations of two approaches of assisted identification based on completely different mathematical concepts: the calculation of the probabilities (used in commercial centres) and the aggregation of pre-orders by a model of assisted decision such as electra ii. in order to reduce the errors of interpretation inherent in t ...19853896052
[present status of the treatment of urological infections]. 19853896135
[muscle hypotonia in urinary tract infection and hyperphosphaturia in infants]. 19853895147
isolation of labeled lipoprotein from escherichia coli and proteus mirabilis after incubation with [14c]penicillin.[14c]penicillin binding experiments and membrane analysis were carried out with cell envelope preparations from escherichia coli and proteus mirabilis. after incubation with [14c]penicillin g labeled free lipoprotein could be identified. the analysis of the isolated lipoprotein by sds polyacrylamide gel electrophoresis indicates that there is only one protein with an apparent molecular weight of 7000. the amino acid composition of isolated labeled free lipoprotein from e. coli was identical to t ...19853895763
temocillin in the treatment of serious gram-negative infections.temocillin was used to treat 32 patients with proven or suspected infection caused by aerobic gram-negative bacteria. 25 of these patients were assessable on clinical and bacteriological grounds. all 25 were either cured or improved, although in 5 patients with urinary tract infection there was relapse of infection or reinfection following the cessation of therapy. clinical improvement was usually rapid and no serious side effect was noted. temocillin would thus appear to be an effective and saf ...19853896739
therapeutic experience with temocillin in peritonitis.the therapeutic efficacy of the new beta-lactam antibiotic, temocillin, was studied in 30 critically ill patients with peritonitis, abscesses, bronchopneumonia, and serious soft tissue infections. patients were treated with temocillin ig intravenously twice daily. the isolated pathogens comprised mainly escherichia coli and proteus, but enterococci, pseudomonas species, klebsiella pneumoniae, citrobacter species, bacteroides species, streptococci and peptococci were also implicated. temocillin w ...19853896740
temocillin treatment of serious infections due to gram-negative bacilli in an intensive care unit.in a group of 27 severely ill patients in an intensive care unit, 40 infections caused by gram-negative bacilli were treated with temocillin 2g twice daily by the direct intravenous route. the patients (17 men and 10 women) were aged from 35 to 93 years (mean 65.7 years) and 22 had severe underlying diseases. in addition, 10 of the patients were admitted to the intensive care unit following surgery; 6 had acute renal insufficiency, 5 had acute respiratory insufficiency, and 12 were suffering fro ...19853896741
an in vitro ultrastructural study of infectious kidney stone genesis.a ureolytic strain of proteus mirabilis, isolated from a patient with infectious kidney stones, produced struvite (mgnh4po4 x 6 h2o) and apatite [ca10(po4)6co3] crystals in vitro when grown in artificial urine. surface-attached crystals were encased in a slime-like layer. scanning electron microscopy revealed that surfaces submerged in the artificial urine were colonized by p. mirabilis. bacteria-associated crystals appeared soon after colonization and eventually became coated with an amorphous ...19853897064
resolution of late-developing periprosthetic breast infections without prosthesis removal.based on prior experience with implant exposure, an aggressive regimen to eradicate periprosthetic infections has proven successful in delayed gram-positive and gram-negative bacterial infections and in atypical microbacterial infections. the objective of the "salvage" procedure is to retain a prosthesis, to maintain breast contour, and to avoid psychological and physical consequences of prosthesis removal. the "salvage" procedure involves topical antisepsis, contracture release if needed, syste ...19853895850
unstable l-form of proteus mirabilis induced by fosfomycin.an unstable l-form of proteus mirabilis was induced on solid medium by sensitivity test discs (200 micrograms of fosfomycin + 20 micrograms of glucose-6-phosphate). the l-colonies were subcultured on agar containing the antibiotic at a concentration of 60 micrograms/ml. on antibiotic-free medium, all the cells reverted to the bacterial phase. on antibiotic-containing agar, the reversion took place as well although at a much lower frequency. parents and revertants differed in glucose metabolism w ...19853896682
clinical evaluation of temocillin in urinary tract infections.a group of 27 female and 2 male urological patients, aged 19 to 80 years (mean 44 years), were treated with intravenous temocillin 500 mg twice daily for 5 to 7 days. the diagnoses were acute pyelonephritis (n = 20), acute cystitis (n = 6), and acute cystitis and pyelonephritis combined (3). the causative organisms were escherichia coli (n = 20). proteus species (n = 9). klebsiella species (n = 4). streptococcus faecalis (n = 2). staphylococcus epidermidis (n = 1), and providencia stuartii (n = ...19853896736
experimental evolution of penicillin g acylases from escherichia coli and proteus rettgeri.proteus rettgeri and escherichia coli w were shown to express structurally different penicillin g acylases. the enzymes had similar substrate specificity but differed in molecular weight, isoelectric point, and electrophoretic mobility in polyacrylamide gels and did not antigenically cross-react. when the organisms were subjected to environmental conditions which made expression of this enzyme essential for growth, spontaneous mutants were isolated that used different amides as the only source o ...19853897200
bacteriological profile of diarrhoea of infants and toddlers in a semi-urban community. 19853897363
[possibilities of enhancing the sensitivity of the coagglutination reaction].the influence of heating shigella suspension at 60 degrees c (for 3 minutes) and 100 degrees c (for 30 minutes), as well as adding extraneous microorganisms (escherichia coli, proteus) and homologous antibodies to these suspensions, on the sensitivity of the coagglutination test has been studied. the possibility of enhancing the sensitivity of this test 10 to 100 times by heating shigella suspensions at 100 degrees c for 30 minutes has been shown.19853898662
[active and passive immune therapy of surgical proteus infection]. 19853898658
[clinical evaluation of cefmenoxime in urinary tract and prostatic infections].cefmenoxime, a new cephalosporin, was given to fifty patients (28 male and 22 female) aged 15 to 86 years with infection of the urinary tract or prostate. urinary tract infections, i.e. cystitis in 20 cases and pyelonephritis in 21, were usually chronic and associated with urologic anomalies. nine patients had infection of the prostate. pathogens recovered from the urine were 26 e. coli, 8 klebsiella, 16 serratia, 5 proteus mirabilis or indole-positive proteus, 1 providencia, and 4 pseudomonas. ...19853897962
nucleotide sequence analysis of the cat gene of proteus mirabilis: comparison with the type i (tn9) cat gene.in proteus mirabilis pm13 chloramphenicol resistance is mediated by the cat gene, a single copy of which is present in both resistant and sensitive isolates and which reverts at a high frequency. rna measurements show an about 8.5-fold increase in cat-specific mrna in cells expressing the resistance phenotype as compared with those which are sensitive to chloramphenicol. dna sequence analysis has revealed a high degree of homology between the p. mirabilis cat gene and the type i cat variant (tn9 ...19853900035
trat gene sequences, serum resistance and pathogenicity-related factors in clinical isolates of escherichia coli and other gram-negative bacteria.the r6-5 plasmid-specified outer membrane protein, trat protein, has previously been shown to mediate resistance to bacterial killing by serum. colony hybridization with a 700 bp dna fragment carrying most of the trat gene was used to examine the prevalence of trat in gram-negative bacteria, particularly strains of escherichia coli, isolated from clinical specimens. trat was found in isolates of e. coli, salmonella, shigella and klebsiella, but not in pseudomonas, aeromonas or plesiomonas, nor i ...19853900279
[distribution and changes in the susceptibility of bacteria isolated from clinical samples. ii].in vitro activity of antimicrobial agents such as abpc, sbpc, mpc, cez, ctm, cmz, ctx, cmx, czx, lmox, cpz, cfs and gm against major clinical isolates, s. aureus, s. pyogenes, e. coli, k. pneumoniae, p. mirabilis, c. freundii, enterobacter spp., s. marcescens, p. vulgaris and p. aeruginosa, was examined. in this paper, we will report the susceptibility of s. aureus, s. pyogenes, e. coli, k. pneumoniae and p. mirabilis during a three-year period, 1981 to approximately 1983. cez- and gm-resistant ...19853900459
[bronchial diffusion of piperacillin in 18 intensive care patients].eighteen patients (13 under mechanical ventilation) in an intensive care unit received piperacillin for pneumonia (7 cases) or bronchial infection (11 cases), related to haemophilus influenzae (7), streptococcus pneumoniae (4) or miscellaneous pathogens (7) including staphylococcus, e. coli, klebsiella pneumoniae and proteus mirabilis. each patient was given 2g piperacillin intravenously every six hours. concentrations in serum and bronchial secretion samples were assayed by the agar diffusion t ...19853897966
resistance to chloramphenicol in proteus mirabilis by expression of a chromosomal gene for chloramphenicol acetyltransferase.proteus mirabilis pm13 is a well-characterized chloramphenicol-sensitive isolate which spontaneously gives rise to resistant colonies on solid media containing chloramphenicol (50 micrograms ml-1) at a plating efficiency of 10(-4) to 10(-5). such chloramphenicol-resistant colonies exhibit a novel phenotype with respect to chloramphenicol resistance. when a single colony grown on chloramphenicol agar is transferred to liquid medium and grown in the absence of antibiotic for 150 generations, a pop ...19853900034
[prostatic tissue levels of ceftizoxime].the concentration of ceftizoxime (czx) was determined in the prostatic tissue and serum of 130 patients with benign prostatic hypertrophy. two grams of czx was given by intravenous injection prior to tur. the mean value of czx levels in prostatic tissue and prostatic level/serum levels ratio (p/s ratio) after administration were 47.2 +/- 2.8 micrograms/g, 49.1% at 30 minutes, 33.3 +/- 2.2 micrograms/g, 51.4% at one hour, 22.2 +/- 2.7 micrograms/g, 60.8% at 2 hours, 13.6 +/- 3.9 micrograms/g, 64. ...19853901702
cell cycle parameters of proteus mirabilis: interdependence of the biosynthetic cell cycle and the interdivision cycle.we investigated the time periods of dna replication, lateral cell wall extension, and septum formation within the cell cycle of proteus mirabilis. cells were cultivated under three different conditions, yielding interdivision times of approximately 55, 57, and 160 min, respectively. synchrony was achieved by sucrose density gradient centrifugation. the time periods were estimated by division inhibition studies with cephalexin, mecillinam, and nalidixic acid. in addition, dna replication was meas ...19853902797
expression of klebsiella pneumoniae nif genes in proteus mirabilis.self-transmissible plasmids carrying his and nif genes from klebsiella pneumoniae have been introduced into three his mutants of proteus mirabilis: strains 5006-1, wr19 and wr20. expression of his by the transconjugants was unequivocal, if slightly temperature-sensitive, but none was nif+ when tested for acetylene reduction in anaerobic glucose medium using inocula from rich or glucose-minimal aerobic agar cultures. succinate or pyruvate in place of glucose, low glucose, lower temperature or ele ...19853899045
prospective randomized comparison of imipenem/cilastatin and cefotaxime for treatment of lung, soft tissue, and renal infections.thirty-one moderately or severely ill hospitalized patients with proved (25 patients) or suspected (six) bacterial infections were randomly allocated to receive imipenem/cilastatin (16) or cefotaxime (15). the median age, sex, duration of therapy, underlying disease, and types of infection were similar in both groups. nineteen patients with pneumonia, eight with soft tissue infection, and four with acute pyelonephritis were included. the pathogens isolated included escherichia coli (six), strept ...19853901207
[carbenicillin resistance of gram-negative bacteria: incidence, biochemical and genetic determinism].of nine hundred ampicillin resistant (amp-r) enterobacteria strains, isolated in hospital between july and december 1981, 73,7% are also carbenicillin-resistant (carb-r). this particular double resistance varies depending upon the species considered: indole positive proteus (23%), enterobacter cloacae (64%), citrobacter freundii (67%), acinetobacter calcoaceticus (73%), proteus mirabilis (75%), serratia marcescens (90%), escherichia coli (91%), providencia stuartii (96%) and klebsiella pneumonia ...19853903620
[clinical and experimental research on some toothpastes].authors assayed in vitro 9 toothpastes (signed a to i) against 8 types of microorganisms. toothpaste d yielded best results, toothpastes a and b shown no antibacterial power; the other ones had intermediate degrees of effectiveness. authors also performed an in vivo study testing 3 toothpastes on to 5 healthy volunteers, but results are not statistically significant.19853903831
mediterranean spotted fever: a cooperative study of 227 cases.the clinical manifestations of 227 cases of mediterranean spotted fever (boutonneuse fever) were reviewed, and the epidemiologic aspects of 170 cases from the vallés occidental region in the county of barcelona, spain, were analyzed. in this area an increase in the incidence of the disease has been noticed during the last several years. the patients evaluated presented with high fever and a generalized maculopapular rash. the tache noire at the site of the tick bite was seen in 166 cases (73%). ...19853903943
[intrarenal abscess in childhood. use of percutaneous aspiration with echography]. 19853904557
[action of biologically active compounds on kanamycin inactivation by resistant microorganisms].products of kanamycin inactivation were identified chromatographically and radiometrically in e. coli 154, k. aerogenes 600 and p. vulgaris 7470. it was shown that the efficiency of kanamycin inactivation in the membrane fraction was 2 times higher than that in cytosol. a decrease in the culture resistance to kanamycin was observed, when the antibiotic was used in combination with the main proteins or phosphonites: a 16-64-fold decrease in the kanamycin mic. comparison of the data on the efficie ...19853904620
imipenem/cilastatin in the treatment of intraabdominal infections: a review of worldwide experience.imipenem is a new broad-spectrum beta-lactam antibiotic, which when administered with cilastatin may be a suitable alternative to the combination of an aminoglycoside and either clindamycin or a nitroimidazole as therapy for intraabdominal infections. the clinical and microbiologic results for 164 assessable patients given imipenem/cilastatin for intraabdominal infections are reported. only three of 416 bacterial strains isolated prior to therapy from intraabdominal infection sites were resistan ...19853901215
evolution of the lipoprotein gene in the enterobacteriaceae. cloning and dna sequence of the lpp gene from proteus mirabilis.we cloned the lipoprotein gene from proteus mirabilis and determined its dna sequence. comparison with the lpp genes from escherichia coli, serratia marcescens, erwinia amylovora and morganella morganii revealed several unique features of the evolution of the lpp gene in the enterobacteriaceae and enabled us to establish phylogenetic relationships between these bacteria.19853903165
cephabacin m1-6, new 7-methoxycephem antibiotics of bacterial origin. i. a producing organism, fermentation, biological activities, and mode of action.new 7-methoxycephem antibiotics were found in culture filtrates of a bacterium isolated from a plant and named cephabacin m1-6. they are the first members of 7-methoxycephem antibiotics of bacterial origin. the producing organism was taxonomically characterized and identified as xanthomonas lactamgena yk-431; other strains of this species have recently been reported to produce cephabacin f and h group antibiotics. cephabacin m1-6 exhibited moderate antibacterial activity against gram-negative an ...19853905734
interspecific reconstitution of maltose transport and chemotaxis in escherichia coli with maltose-binding protein from various enteric bacteria.in escherichia coli, the periplasmic maltose-binding protein (mbp), the product of the male gene, is the primary recognition component of the transport system for maltose and maltodextrins. it is also the maltose chemoreceptor, in which capacity it interacts with the signal transducer tar (taxis to aspartate and some repellents). in studies of the maltose system in other members of the family enterobacteriaceae, we found that mbp is produced by salmonella typhimurium, klebsiella pneumoniae, ente ...19853905762
hyperammonemic coma due to proteus infection.hyperammonemic coma without liver disease or associated deficiencies in urea cycle enzymes is rare. we report a case and discuss the pathophysiological findings of hyperammonemic coma secondary to proteus mirabilis urinary tract infection.19853903220
[proteus mirabilis meningitis presenting as hydrocephalus in an infant]. 19853905538
[study of clinical bacteriological efficacy in a cefmenoxime ototopical solution].one percent cefmenoxime (cmx) ototopical solution was administered to 302 patients with purulent otitis media and acute diffuse external otitis in open study fashion, and to 216 patients with purulent otitis media in double blind condition. from among the total of 518 cases various bacteria were detected, except 22 of negative detection after incubation and 3 of impossible determination. the main bacteria detected from the above 493 cases were s. aureus (242 strains = 49.1%), p. aeruginosa (105 ...19853906166
ceftriaxone: a beta-lactamase-stable, broad-spectrum cephalosporin with an extended half-life.ceftriaxone is an aminothiazolyl-oxyimino cephalosporin. it possesses the typical in vitro activity of a third-generation cephalosporin with excellent activity against many gram-negative aerobic bacilli: escherichia coli; species of proteus, klebsiella, morganella, providencia and citrobacter; and enterobacter agglomerans. ceftriaxone also has outstanding bactericidal action against pneumococci, group b streptococci, meningococci, gonococci and hemophilus influenzae. in healthy volunteers, it ha ...19853906584
urinary tract infection in renal transplant patients.the incidence of urinary tract infections (uti) in 299 renal graft transplantations (281 patients) was analyzed. uti episodes were demonstrated in 185 grafts (62%), most frequently in the first month after transplantation. the infectious episodes were mostly recurrent. persistent infection, detected in 11% of grafts, was associated with urologic complications in almost all cases. no significant correlation between the primary renal disease and the uti rate was found, and there was no significant ...19853905620
use of the hickman catheter for the treatment of lower extremity infections.the authors discuss the use of a cuffed, silastic catheter, which can be of great value in the reduction of morbidity when dealing with lower extremity infections. when a patient's condition demands the use of long-term antibiotic and/or aminoglyoside therapy, this indwelling central venous catheter can allow easy access to the vascular system and markedly decrease the amount of time the patient has to stay in the hospital. this form of therapy involves the patient in the treatment and displays ...19853905931
penetrability of the smeared layer by a strain of proteus vulgaris. 19853906016
[neonatal meningitis caused by proteus mirabilis with cerebral abscess].a case neonatal meningitis by proteus mirabilis is presented. echographic and ct scan studies were performed during clinical evolution, showing generalized brain abscesses appearances that needed surgical treatment. a ventriculo-peritoneal shunt was later practiced to correct hydrocephaly.19853907449
[immunostimulating activity of combined antigens of klebsiella pneumoniae, staphylococcus, proteus and escherichia coli and separate components in cross infection].experiments on mice have revealed that the combined preparation of k. pneumoniae, staphylococcus, proteus and e. coli antigens possesses pronounced immunostimulating activity against the microorganisms whose antigens make up this combined preparation, as well as against haemophilus influenzae, type b. cross protection between the antigens making up the preparation was observed, as well as of each of its components with respect to h. influenzae, type b. the activity of the combined antigenic prep ...19853907218
[epidemiological application of the cradock-watson system for proteus mirabilis. comparative study with another system of bacteriocin typing]. 19853906814
[comparison of in vitro antibacterial activities of new cephems against clinical organisms (isolated between june 1983 and january 1984)].we compared the in vitro antibacterial activities of ceftizoxime (czx), cefotaxime (ctx), cefmenoxime (cmx), cefoperazone (cpz), ceftazidime (caz), latamoxef (lmox) and cefotetan (ctt) against 2,729 strains of 11 organisms freshly isolated from 10 medical institutions in japan between june 1983 and january 1984 and obtained the following results: against s. pyogenes, lmox and ctt, which have the methoxy group at the 7 position, were less active than the other drugs. lmox inhibited 80% of s. pyog ...19853908734
development of improved methods for the transport and isolation of haemophilus somnus.the survival of several strains of haemophilus somnus under various simulated transport conditions was investigated. recovery of h somnus from alginate swabs kept at room temperature was possible for up to 27 hours after sampling, but this period could be extended to 72 hours if the swabs were refrigerated. storage of swabs in transport media did not prolong survival time significantly but did increase the number of bacterial contaminants, thus making recovery of h somnus less likely. the sensit ...19853909276
[bacterial identification and mathematical modeling]. 19853909286
comparison of aztreonam and tobramycin in the treatment of lower respiratory tract infections caused by gram-negative bacilli.a comparison of aztreonam and tobramycin was carried out in 49 hospitalized patients with lower respiratory tract infections caused by gram-negative bacilli. patients were randomly assigned to the treatment drug. clindamycin was given concomitantly until the pathogen was identified and the presence of a gram-positive microorganism was ruled out. samples of sputum were obtained for culture from the lung parenchyma by deep expectoration or transtracheal aspiration. a pathogen was defined as an org ...19853909321
role of aerobic gram-negative bacilli in endometritis after cesarean section.endometritis is considered to be a polymicrobial infection, involving aerobes, anaerobes, and genital mycoplasmas. aerobic gram-negative rods make up 7%-25% of all genital isolates, but findings from studies in which special collection techniques were used suggest that many of these may be contaminants from the lower genital tract. bacteremia occurs in 4%-30% of patients with endometritis, and aerobic gram-negative rods account for approximately 25% of blood isolates. both selected therapy studi ...19853909325
[characteristics of various morphological and biological properties of bacteria of the genus proteus].the stable o-form of proteus has been found to differ from the initial h-form in the absence of flagellae or in a few weakly developed flagellae, in decreased capacity for agglutination with polyvalent and typing sera and in virulence for laboratory animals. as revealed in this study, the conversion of the h-form of proteus into the stable o-form leads to the loss of resistance to streptomycin, chloramphenicol, tetracycline, monomycin, ampicillin and neomycin.19853907216
the effect of a range of antimicrobial drugs on the haemagglutination of two clinical isolates from urinary tract infections.a range of nine common antimicrobial drugs were tested for their effect on adhesion of the mannose-resistant haemagglutination-positive proteus vulgaris strain bh77 and escherichia coli strain bh121, isolated from patients with urinary tract infections. minimum inhibitory concentrations of the antimicrobials for these strains were determined in mueller-hinton broth and the effect of each antimicrobial, at the quarter mic values, on the haemagglutination of the strains was then determined. haemag ...19853908437
microbicidal activity of octenidine hydrochloride, a new alkanediylbis[pyridine] germicidal agent.the potential of octenidine hydrochloride (win 41464-2) as a topical microbicide was measured both by in vitro death kinetics and reductions in numbers of bacteria on the skin of cynomolgus monkeys. semilogarithmic survival curves were plotted to measure the microbicidal activity of various concentrations of octenidine against staphylococcus aureus. the microbicidal activity of octenidine was also determined for staphylococcus epidermidis, proteus mirabilis, streptococcus pyogenes, klebsiella pn ...19853909955
proteus mirabilis osteomyelitis. 19853907685
[biochemical properties of enterobacteria on polystyrene plates].the authors studied 84 strains of enterobacteria. the reliability of the results of the biochemical testing obtained by the micromethod with the use of polystyrene plates was examined comparatively to the data obtained by the classical method and api microsystems manufactured in france. of the 84 strains of enterobacteria, 36 belonged to proteus, 24 to enterobacter, 8 to klebsiella, 5 to citrobacter, and 11 to e. coli. of the strains tested, 50 were isolated from the intestine of children and ad ...19853909634
[renal infections and implicated urinary stone formation].to clarify the relationship between urinary tract infections and stone formation, infected renal calculi removed surgically from 19 patients were investigated. first, the stones were studied using a scanning electron microscope and bacteriological method. most of the stone cores consisted of calcium phosphate and organic materials containing bacteria, fibrin, erythrocytes, leukocytes and so on. second, in experimental ascending pyelonephritis in rats which received the intravesical instillation ...19853909792
antimicrobial activity of clavines.the antimicrobial activity of two clavine-type ergot alkaloids (agroclavine, festuclavine), and 16 derivatives against four human pathogenic bacteria and candida albicans was determined. it is shown that all ergolines tested with one exception exhibit antibacterial properties against one to four bacteria species. the most active compounds are 6-allyl-6-norfestuclavine (minimal inhibitory concentration (mic) 30 micrograms/ml against staphylococcus aureus), 1-propyl-6-norfestuclavine (mic 60 micro ...19853913422
[bacteriocin types of proteus isolated from diagnostic specimens]. 19853913990
[multicenter study of the in vitro effect of imipenem (n-formimidoyl-thienamycin) on hospital bacteria].minimal inhibitory concentrations (mics) of imipenem were evaluated by agar dilution for 2 895 bacterial strains isolated in 9 hospitals. imipenem proved highly active against enterobacteriaceae, with an mic less than or equal to 0.25 for 63% of the 1 556 tested strains, less than or equal to 1 for 89.6% and less than or equal to 4 for 99%. the different groups of enterobacteriaceae exhibited similar mode mics (0.12 to 0.25), with the exception of serratia (0.25-0.5), p. mirabilis (0.5), indole- ...19853911142
swarmer cell differentiation of proteus mirabilis in fluid media.after 3-4 h in a rich fluid medium such as brain--heart infusion broth, motile nonseptate filaments developed from normal short rods and formed about 80% of the cell mass of proteus mirabilis pm23. this developmental pattern was not observed in any of the other nine representatives of the species. these filaments were considered to be equivalent to swarmer cells formed on agar media because these cells ceased tumbling (i.e., chemotaxis was repressed), they developed large numbers of flagella (i. ...19853912035
studies on specificity of protection induced by immunization with outer membrane proteins of shigella.immunization of c3h/hej mice with outer membrane proteins (omp) and with peptidoglycan associated proteins (pgp) isolated from shigella flexneri 3a and from shigella sonnei phase i protected the animals against lethal dose of homologous and heterologous bacteria and against various serotypes of shigella flexneri. neither of the protein preparations protected the animals against challenge with escherichia, klebsiella, citrobacter, salmonella, serratia, proteus and pseudomonas. omp preparations ho ...19853914866
influence of rp4 plasmid on extracellular protease secretion by proteus mirabilis.the transference by conjugation of protease genetic information between proteus mirabilis strains only occurs upon mobilization by a conjugative plasmid such as rp4 (inc p group). upon receiving the rp4 plasmid, the level of proteolytic activity of the protease-excreting p. mirabilis is reduced to about 50%. a similar phenomenon occurs when the protease character is mobilized by the rp4 plasmid from the above transconjugant to a non-protease-excreting recipient strain. the molecular mechanism un ...19853915216
cefmetazole: a broad spectrum cephem antibiotic effective on methicillin- and cephem-resistant staphylococcus aureus.antibacterial activity of cefmetazole (cmz) was investigated by the plate dilution method. since cmz is stable to any type of bacterial beta-lactamases, it inhibited growth of escherichia coli carrying r plasmids, klebsiella spp., proteus vulgaris, and bacteroides fragilis at the concentration of less than 0.78 to 25.0 micrograms/ml. the distinct characteristic of cmz is its anti-mrsa (methicillin- and cephem-resistant staphylococcus aureus) activity. exclusively in mrsa, a new fraction of penic ...19853915273
urinary tract infections after renal transplantation.from 1980 to 1983, 69 patients (36 male) with end-stage renal disease underwent kidney transplantation (11 from cadaveric donors). twenty-six out of 69 (17 male) with a mean age of 37 years (range 16-50 years) developed 69 uti episodes. the standard immunosuppressive regimen consisted of prednisolone and azathioprine and, in selected cases, antilymphocyte globulin or cyclosporin a were given for a short period of time. thirty-five episodes (50%) occurred within two months of the operation. the m ...19853915278
position of ceftazidime in respiratory diseases.twenty patients (10 males and 10 females), ranging in age from 53 to 81 years, were treated with ceftazidime, 2-3 g/day i.m., for 12 to 15 days. all patients were suffering from moderate to severe infections of the lower respiratory tract (6 cases of pneumonia and 14 cases of acute exacerbation of chronic bronchitis). in addition, almost all patients presented severe local and general predisposing factors (three patients with lung cancer, two with bronchiectasis and 14 with respiratory insuffici ...19853915288
bacteriology of sore throats in a sudanese population.one hundred and eighty-six throat swabs were collected from patients with sore throats and 164 throat swabs were collected from healthy controls. all swabs were investigated bacteriologically, and sensitivity tests were performed on all pathogenic isolates. group a streptococcus pyogenes was the predominant pathogenic organism (24.7%) and proteus vulgaris the least predominant organism (0.5%) isolated from patients with sore throats. streptococcus pyogenes infection was found to be most common a ...19853915330
the changing bacteriology of recurrent pyogenic cholangitis in hong kong.when the results of bile cultures of rpc patients, admitted to queen mary hospital in 1973-74 and 1979-80, were analysed together with data obtained from the publication of previous investigators, a change in the bacteriology of the disease was noted. the percentage of rpc patients was affected by e. coli was on the decline while, in contrast, a higher percentage of patients was affected by the other enterobacteriaceae (especially klebsiella spp. and proteus spp.) and the non-glucose fermenters. ...19853915512
preparation and testing of an autolysate of fish viscera as growth substrate for bacteria.the aqueous soluble phase of acidified and autolyzed fish viscera was used as the nitrogen source in a growth medium for bacteria. the bacteria tested grew faster and produced higher yields of cell mass on this growth medium than on corresponding media with standard tryptone preparations as the nitrogen source.19853911909
comparison of aminoglycoside resistance patterns in japan, formosa, and korea, chile, and the united states.the resistance mechanisms of more than 2,000 aminoglycoside-resistant gram-negative aerobic bacteria were estimated by a method that assigned a biochemical mechanism based on susceptibility to selected aminoglycosides. strains from hospitals in japan, formosa, and korea (the far east) were compared with strains from chile and the united states. of the strains from chile, 90% had an aminoglycoside resistance pattern indicative of the 3-n-acetyltransferase [aac(3)-v] enzyme. of the strains from th ...19853914858
[ultrastructural characteristics of stable l forms of some bacterial species]. 19853914828
prevalence of asymptomatic bacteriuria and comparison between different screening methods for its detection in infants.urine was cultured from 441 healthy children, aged 3 to 36 months, simultaneously by standard pour plating and by dip-slide. significant bacteriuria (greater than or equal to 10(5) colony-forming units/ml in two successive specimens) was found in 13 children (2.9%): 11 boys, 2 girls. proteus mirabilis was the most frequently isolated organism. of the 13 infants, 2 had malformations on intravenous pyelography. all 13 had a negative antibody-coated bacteria test. nitrite test (n-multistix) and mic ...19853915983
a study on the incidence of nosocomial infections in a large university hospital.the results of a study on the incidence of nosocomial infections in a 1800 bed university hospital are reported. the study, carried out over a 9 months period, included: continuous microbiological surveillance, and a clinical and epidemiological survey. on the basis of the microbiological data collected and analyzed by a computer data system, developed and employed for the control of nosocomial infections, a weekly bed-to-bed survey was carried out by the staff of the institute of infectious dis ...19853916098
[microbiological and pathomorphologic characteristics of experimental intestinal proteus infections]. 19853917193
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