| nitrosamine formation by denitrifying and non-denitrifying bacteria: implication of nitrite reductase and nitrate reductase in nitrosation catalysis. | biochemical, microbiological and genetic studies were done to characterize the mechanism of bacterial formation of n-nitrosomorpholine (nmor) from morpholine and nitrite at neutral ph. in escherichia coli and proteus morganii, the nitrosating activity was markedly induced when bacteria were cultured under anaerobiosis in minimal medium containing nitrate, while in the presence of nitrite there was no induction. however, induction of the nitrosating activity in pseudomonas aeruginosa occurred in ... | 1988 | 3141563 |
| mechanism of inhibition of chromosomal beta-lactamases by third-generation cephalosporins. | the kinetic interactions of the beta-lactamase from enterobacter cloacae 908 r with ceftriaxone, cefotaxime, and ceftazidime have been examined in detail. with all of these cephalosporins, there is an initial rapid reaction involving opening of the beta-lactam that then decreases to a slower steady-state rate (kss) of beta-lactam hydrolysis (at 37 degrees c: ceftriaxone, kss = 0.044 s-1; cefotaxime, kss = 0.033 s-1; ceftazidime, kss = 0.011 s-1). more than stoichiometric quantities of beta-lacta ... | 1988 | 3142012 |
| evaluation of plasmid-encoded beta-lactamase resistance in escherichia coli blood culture isolates. | the frequency of beta-lactam resistance was determined among 313 strains of escherichia coli, 119 of enterobacter/klebsiella/proteus spp., and 48 of pseudomonas spp. isolated from blood cultures (at turku university central hospital and turku city hospital) in 1983-1987. during this period the mic50 of ampicillin for escherichia coli increased from 8 to 32 micrograms/ml, the mic90 of piperacillin from 16 to greater than 32 micrograms/ml and the mic90 of cefuroxime from 4-8 to 16 micrograms/ml. a ... | 1988 | 3143575 |
| the penetration of fleroxacin into intra-abdominal abscesses. | using a recently developed, low mortality model of an intra-abdominal abscess in the wistar rat, we have studied the penetration of fleroxacin into the abscess. maximum serum concentration was 1.83 +/- 0.39 mg l and occurred 1 h after iv injection (20 mg/kg), but even at 4 h after administration the mean serum level was 1.21 +/- 0.27 mg/l. by contrast, levels in pus were 6.27 +/- 0.83 mg/l at 1 h rising steadily to a value of 12.7 +/- 3.69 mg/l at 4 h. the study has confirmed exceptional antibio ... | 1988 | 3144528 |
| fleroxacin in single dose oral therapy of uncomplicated lower urinary tract infection. | a randomized comparative study was performed in twenty women with acute uncomplicated lower urinary tract infection (uti). they received a single oral dose of either fleroxacin 600 mg or amoxycillin 3 g. pathogens were escherichia coli (17), proteus mirabilis (2) and staphylococcus aureus (1). a complete clinical and microbiological cure was observed in all patients of both groups. one patient in the fleroxacin group had gastric irritation. a single oral dose of fleroxacin may be suitable for th ... | 1988 | 3144541 |
| in-vitro activity of fleroxacin against urinary tract and genital tract pathogens. | the activity of fleroxacin was compared to those of nalidixic acid, ampicillin, trimethoprim-sulphamethoxazole, tetracycline and penicillin against a total of 452 strains isolated from urinary tract and genital tract infections. these included strains resistant to gentamicin, methicillin-resistant staphylococcus aureus and beta-lactamase producing strains. mics were determined by a standard agar dilution procedure using mueller-hinton agar. fleroxacin inhibited 90% of escherichia coli, klebsiell ... | 1988 | 3144546 |
| [susceptibility of clinically isolated strains to aztreonam]. | in vitro antibacterial activities of aztreonam (azt) and cephems against clinically isolated 334 strains were investigated. the results obtained in the study are summarized as follows: 1. azt showed excellent antibacterial activities against clinically isolated 334 strains. 2. azt showed potent activities against escherichia coli, klebsiella pneumoniae, proteus spp., enterobacter aerogenes and citrobacter freundii. 3. antibacterial activities of azt were superior against enterobacter cloacae, se ... | 1988 | 3145344 |
| [synthesis and antimicrobial activity of several o-dialkylaminoalkylated adamantane ketoximes and carbohydroxamic acids]. | | 1988 | 3145691 |
| purification and characterization of three forms of glutathione transferase from proteus mirabilis. | three forms of glutathione transferase (gst) with pi values of 6.0, 6.4 and 7.3 were isolated from proteus mirabilis af 2924 by glutathione-affinity chromatography followed by isoelectric focusing, and their structural, kinetic and immunological properties were investigated. upon sds/polyacrylamide-slab-gel electrophoresis, all forms proved to be composed of two subunits of identical (22,500) mr. gst-6.0 and gst-6.4 together account for about 95% of the total activity, whereas gst-7.3 is present ... | 1988 | 3145740 |
| preliminary studies on the mechanism of infection and characterization of malassezia pachydermatis in association with canine otitis externa. | a study on the mechanism of infection and the characterization of malassezia pachydermatis in connection with canine otitis externa was conducted. the ability of this yeast to grow uninhibited in intimate contact with the diversity of other microbial isolants of the canine aural canal was demonstrated. canine cerumen seemed to promote the growth of this yeast. although the source of infection is still obscure, m. pachydermatis managed to survive in soil and dust at different temperatures for fou ... | 1988 | 3146702 |
| antibacterial activity after a single-dose of norfloxacin, ofloxacin and pipemidic acid detected in urine of volunteers. | six healthy volunteers received in a triple-crossover design a single oral dose of norfloxacin, ofloxacin or pipemidic acid. urine samples were collected during the 24 h following the administration and were tested for inhibitory and bactericidal activity against selected strains of enterobacteriaceae and pseudomonas aeruginosa. norfloxacin and ofloxacin inhibited the urinary growth of sensitive strains during the 24 h of sampling time at dilutions much higher than those generally considered sat ... | 1988 | 3150350 |
| in vitro studies of synergistic interaction between aztreonam and cefoperazone. | | 1987 | 3151329 |
| bacteriostatic and bactericidal effect of ceftriaxone on hemophilus, neisseria meningitidis, and proteus. | | 1987 | 3151360 |
| understanding proteus syndrome, unmasking the elephant man, and stemming elephant fever. | four patients with proteus syndrome are reported; 3 of the 4 died of unusual causes. current findings of the syndrome are reviewed, and the present state of its delineation is assessed with emphasis on what is known about natural history. differential diagnosis includes neurofibromatosis, klippel-trénaunay-weber syndrome, maffucci syndrome, epidermal nevus syndrome, and the combination of bannayan-zonana syndrome, riley-smith syndrome, and ruvalcaba-myhre syndrome, now thought to constitute a si ... | 1988 | 3152479 |
| urinary infection and staghorn calculus in the left kidney. | | 1988 | 3153046 |
| copper resistance in bacteria. | copper is a required trace element for many organisms, yet it can exert an inhibitory effect on bacterial growth at relatively low concentrations. however, there are some bacterial species that can tolerate high levels of copper. it also has been reported that copper resistance is plasmid-encoded in escherichia coli, proteus vulgaris and a pseudomonas syringae isolate. it is not known if copper is effluxed from the cell, detoxified by binding to copper-binding proteins, or binds to cell-surface ... | 1987 | 3153166 |
| in-vitro activity of pefloxacin compared to enoxacin, norfloxacin, gentamicin and new beta-lactams. | the in-vitro activity of pefloxacin was compared with that of norfloxacin, enoxacin, nalidixic acid, gentamicin, cefotaxime, ceftazidime and, where appropriate, other beta-lactams against a total of 363 recent clinical isolates. an agar dilution procedure was used to determine mics and two inocula (10(4) and 10(6) cfu) were used throughout. pefloxacin inhibited 90% of isolates of escherichia coli, klebsiella pneumoniae, proteus mirabilis, indole-positive proteus spp., enterobacter spp., shigella ... | 1985 | 3156112 |
| in vitro antibacterial activity of norfloxacin and other agents against ocular pathogens. | 302 clinical isolates representing 16 bacterial species most often implicated in ocular infections were tested in vitro against norfloxacin and a panel of antibacterial agents. on the basis of the 90% minimal inhibitory concentration (mic90) data, norfloxacin was 4-32 times more active than the next best antimicrobial tested against citrobacter freundii, escherichia coli, morganella morganii, proteus mirabilis, proteus vulgaris, haemophilus influenzae, neisseria gonorrhoeae and staphylococcus ep ... | 1985 | 3157551 |
| comparative in vitro activity of three new quinolone antibiotics against recent clinical isolates. | new orally absorbable quinolone derivatives, ciprofloxacin, norfloxacin, and ofloxacin demonstrated excellent activity in vitro against clinical isolates of escherichia coli, klebsiella, enterobacter, proteus mirabilis, proteus sp. indole-positive, pseudomonas aeruginosa, serratia marcescens, staphylococcus aureus, streptococcus pyogenes and enterococci. none of the 3 drugs was more than moderately effective against bacteroides fragilis. ciprofloxacin was 2-4 times more effective against most gr ... | 1985 | 3158070 |
| comparative in vitro activity of norfloxacin and seven other antimicrobial agents against clinical isolates from urinary tract infections. | the in vitro activity of norfloxacin, a new quinolone derivative, was tested against 469 clinical isolates derived mainly from urinary samples from outpatients. it inhibited all escherichia coli, klebsiella oxytoca and proteus strains at a concentration of 0.25 micrograms/ml, and all pseudomonas aeruginosa, enterobacter, klebsiella pneumoniae, staphylococcus and enterococcus strains at a concentration of 8 micrograms/ml or less. norfloxacin proved to be more effective than nalidixic acid, trimet ... | 1985 | 3158071 |
| norfloxacin versus trimethoprim-sulfamethoxazole in the therapy of uncomplicated, community-acquired urinary tract infections. | in a prospective, randomized trial, norfloxacin (400 mg perorally, twice a day) was compared with trimethoprim-sulfamethoxazole (160-800 mg perorally, twice a day) in 45 patients with uncomplicated urinary tract infections. escherichia coli was the most common isolate. infections due to enterobacter spp., proteus mirabilis, pseudomonas spp., and staphylococcus spp. were also treated. norfloxacin was equivalent in effectiveness and safety to trimethoprim-sulfamethoxazole, with a cure rate of 91% ... | 1985 | 3158277 |
| [gram-negative bacteria in a medical resuscitation unit. distribution of species and antibiotic sensitivity]. | the distribution of gram-negative bacilli species and their susceptibility to various antibiotics were surveyed over a 18-month period in an intensive care unit. gram-negative bacilli were isolated from blood cultures (65), urine cultures (191), respiratory tract samples (176) or miscellaneous samples (69). the bacilli most frequently isolated from blood cultures were enterobacteriaceae (95%), including escherichia coli (46%), proteus (22%) and klebsiella pneumoniae (12%). pseudomonas aeruginosa ... | 1985 | 3158892 |
| cross resistance of quinolone derivatives in gram-negative bacteria. | a total of 127 gram-negative bacteria resistant to nalidixic acid were isolated from as many patients affected by urinary tract infections and hospitalized in the first clinic of infectious diseases, university of naples. enterobacteria were identified by enterotube system (roche) and api 20 system (ayerst). non-fermentative bacteria were identified by oxi/ferm system (roche). the following bacteria were collected: escherichia coli 50, proteus spp. 35, enterobacter agglomerans 12, serratia sp. 5 ... | 1985 | 3159488 |
| [frequency of in vitro sensitivity to netilmicin and ceftizoxime on selected highly resistant flora in surgical intensive therapy]. | the in vitro sensitivity of 132 gram positive and gram negative bacterial strains to netilmycin and ceftizoxime was assessed in order to update the statistics on the a priori efficacy of the antibacterial drugs. the flora studied were carefully selected as an extreme case of resistance to the standard antibiotics. netilmycin was found to be effective against staphylococci, pseudomonas and enterobacter, ceftizoxime against serratia, acinetobacter, proteus and klebsiella. both drugs were equally e ... | 1988 | 3162558 |
| [susceptibilities of clinical isolates to antibacterial agents. focusing mainly on ofloxacin (first report). reported by the research group for testing ofloxacin susceptibility of clinical isolates]. | susceptibility tests were carried out on a variety of clinically isolated pathogens using the susceptibility disc method at 197 hospitals in japan between may, 1985 through march, 1986. these tests were organized by the research group for testing ofloxacin susceptibility on clinical isolates, and the results were statistically analyzed. this paper describes a comparison of susceptibilities of clinical isolates including staphylococcus aureus, staphylococcus epidermidis, enterococcus faecalis, st ... | 1988 | 3163383 |
| in vitro antibacterial activity of imipenem in combination with newer quinolone derivatives. | the antibacterial activity of imipenem combined with norfloxacin, ciprofloxacin, or ofloxacin against 43 gram-positive cocci and 53 aerobic gram-negative rods compared to results obtained with the combination of imipenem with amikacin. synergistic antibacterial action (defined as fic index less than or equal to 0.5) was found for 28% of strains with imipenem/amikacin and imipenem/norfloxacin, in 23% with imipenem/ofloxacin, and in 18% with imipenem/ciprofloxacin. antagonistic activity (fic index ... | 1988 | 3164670 |
| in vitro activity of lomefloxacin (sc-47111; ny-198), a difluoroquinolone 3-carboxylic acid, compared with those of other quinolones. | lomefloxacin (sc-47111; ny-198) is a new difluoroquinolone agent. it inhibited 90% of escherichia coli, klebsiella spp., enterobacter spp., citrobacter spp., proteus mirabilis, morganella morganii, proteus vulgaris, serratia marcescens, salmonella spp., shigella spp., aeromonas spp., yersinia spp., haemophilus influenzae, and neisseria gonorrhoeae at less than or equal to 2 micrograms/ml. lomefloxacin inhibited 90% of pseudomonas aeruginosa at 4 micrograms/ml. lomefloxacin was equal in activity ... | 1988 | 3164987 |
| post-processing microflora and the shelf stability of gari marketed in port harcourt. | gari was examined for its post-processing microbial content. aerobic mesophilic bacteria and fungi were isolated from all samples. the total viable bacterial counts ranged from 2.0 x 10(2) to 8.0 x 10(4) cfu/g. fungal counts ranged from 1.0 x 10(2) to 1.5 x 10(4) cfu/g. the total viable counts of fresh samples were much lower than those of market and packaged samples. bacillus, micrococcus and proteus spp. were the bacteria isolated, aspergillus niger, aspergillus flavus and penicillium spp. the ... | 1988 | 3170384 |
| the urease enzymes of campylobacter pylori and a related bacterium. | the urease enzyme of campylobacter pylori was studied and compared with that of a related spiral-shaped bacterium, st1, isolated from the rodent ileum. both bacteria possessed constitutive urease enzymes with activities up to 20-70 times that of proteus vulgaris. this activity was retained on sds-polyacrylamide gels. a major catalytic subunit of mol. wt 300,000 was located for all (six) strains of c. pylori subjected to sds-page whereas st1 had two active forms of mol. wts 140,000 and 150,000. w ... | 1988 | 3172169 |
| [susceptibility of gram-negative bacterial isolates to six beta-lactam and two aminoglycoside antibiotics at our university hospital]. | susceptibilities of gram-negative bacterial strains isolated at the university hospital in 1987 to six beta-lactam antibiotics (azthreonam cefmetazole, ceftizoxime, latamoxef, aminobenzyl-penicillin and piperacillin) and two aminoglycoside antibiotics (gentamicin and amikacin) were examined by agar dilution and the agar diffusion method. results obtained from both methods correlated well in most of the strains. most of the strains belonging to escherichia coli, klebsiella oxytoca, klebsiella pne ... | 1988 | 3175388 |
| time-kill studies and synergy testing of broad-spectrum antibiotics against blood culture isolates. | time-kill studies and synergy testing were performed with blood culture isolates from 80 patients with septicemia. ten isolates each of escherichia coli, proteus mirabilis, indole-positive proteus, klebsiella pneumoniae, enterobacter cloacae, pseudomonas aeruginosa, staphylococcus aureus, and coagulase-negative staphylococci were included. the isolates were tested against netilmicin, piperacillin, cefoxitin, cefuroxime, and cefotaxime, alone and in different combinations. cefotaxime was the most ... | 1988 | 3180908 |
| in-vitro and in-vivo activities of t-3262, a new pyridone carboxylic acid. | t-3262[p-toluenesulfonic acid salt of dl-7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1, 4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid monohydrate] is a new pyridone carboxylic acid with a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria. the activity of t-3262 against most enterobacteriaceae was comparable with that of ciprofloxacin except proteus spp. and providencia rettgeri and exceeded that of ofloxacin and norfloxacin. the activ ... | 1988 | 3182417 |
| comparative in-vitro activity of tigemonam, a new monobactam. | the in-vitro activity against gram-negative aerobic bacterial pathogens of a new oral monobactam, tigemonam, was compared with those of amoxycillin/clavulanic acid, aztreonam, cefaclor, ceftazidime, cefuroxime, ciprofloxacin, co-trimoxazole and gentamicin, by an agar-dilution method. tigemonam inhibited 90% of strains tested of escherichia coli, klebsiella spp., proteus spp., salmonella spp., haemophilus influenzae and branhamella catarrhalis at concentrations of 0.25 mg/l or below. the mic90 fo ... | 1988 | 3182428 |
| antimicrobial activity of ly163892, an orally administered 1-carbacephem. | ly163892 was found to be similar to cefaclor and slightly superior to cephalexin in antimicrobial activity and spectrum. bacteria with mic50 less than or equal to 8.0 mg/l included escherichia coli, klebsiella spp., proteus mirabilis, citrobacter diversus, haemophilus influenzae, branhamella catarrhalis, pathogenic neisseria spp., oxacillin-susceptible staphylococci, and streptococcus spp. strains that produced plasmid-mediated beta-lactamases generally remained susceptible to ly163892. ly163892 ... | 1988 | 3182429 |
| [use of proteus vaccine in chronic diseases of the intestines]. | | 1988 | 3184814 |
| bacterial population and histologic changes in dogs with perianal fistula. | ages of 44 dogs with perianal fistula, ranged from 6 months to 13 years (mean, 5.2 years). german shepherd dogs and irish setters were statistically (p less than 0.01) over-represented compared with those breeds in a canine hospital population (n = 22,047) for the same period. there was a 2:1 male-to-female ratio, with 38 (86.4%) of dogs sexually intact and 6 (13.6%) of dogs neutered. eleven types of bacterial organisms were recovered from deep perianal tissues of which escherichia coli, staphyl ... | 1988 | 3189990 |
| antibacterial properties of (2,3)-alpha- and (2,3)-beta-methylene analogs of penicillin g. | the penam nucleus can assume two conformations; these are designated open and closed. the synthetic (2,3)-alpha- and (2,3)-beta-methylenepenams can be regarded as analogs of the open and closed conformations, respectively. it has been shown that the beta-methylenepenams are essentially inactive, suggesting that the closed conformation of penams is also inactive. in this study, we investigated a series of beta-lactams, all of which contained phenylacetamido side chains: penicillin g, the (2,3)-al ... | 1988 | 3190190 |
| in vitro activity of u-76,252 (cs-807), a new oral cephalosporin. | u-76,252 is the prodrug of u-76,253. mics of u-76,253 were 0.015 to 0.06 microgram/ml for greater than or equal to 90% of the strains of streptococcus spp., haemophilus influenzae, and proteus mirabilis; 0.25 to 1 microgram/ml for branhamella catarrhalis, escherichia coli, klebsiella spp., and citrobacter diversus; 1 to 8 micrograms/ml for staphylococcus spp.; and 2 to greater than 16 micrograms/ml for other members of the family enterobacteriaceae and aeromonas hydrophila; for 72% of the latter ... | 1988 | 3190194 |
| [characteristics of the course of abscesses during effects on the system of phagocytosing mononuclear cells]. | in a series of experiments on 230 noninbred white rats the trend in the development of soft tissue abscess was investigated under stimulation and inhibition of phagocytizing mononuclear cells (pmc). the results suggest the stimulation to promote more reliable localization of the inflammation focus and encapsulation with connective tissue. the test for alpha-naphthyl esterase and quantitation of macrophages (absolute number) per infiltration area unit adjacent to the abscess suggest a direct corr ... | 1988 | 3190481 |
| isotope effect studies of the pyridoxal 5'-phosphate dependent histidine decarboxylase from morganella morganii. | the pyridoxal 5'-phosphate dependent histidine decarboxylase from morganella morganii shows a nitrogen isotope effect k14/k15 = 0.9770 +/- 0.0021, a carbon isotope effect k12/k13 = 1.0308 +/- 0.0006, and a carbon isotope effect for l-[alpha-2h]histidine of 1.0333 +/- 0.0001 at ph 6.3, 37 degrees c. these results indicate that the overall decarboxylation rate is limited jointly by the rate of schiff base interchange and by the rate of decarboxylation. although the observed isotope effects are qui ... | 1988 | 3191100 |
| plasmodium relictum as a cause of avian malaria in wild-caught magellanic penguins (spheniscus magellanicus). | avian malaria (plasmodium relictum) caused significant mortality in wild-caught magellanic penguins (spheniscus magellanicus) in 1986 at the blank park zoo in des moines, iowa (usa). in early winter, wild birds were captured off the southern coast of chile and flown to detroit, michigan for a 38 day quarantine. after quarantine, 18 birds were dispersed to lansing, michigan, six to a facility in maine, and 46 to des moines, iowa. upon arrival in des moines, several penguins became weak and inacti ... | 1988 | 3193555 |
| association of reactive arthropathy and morganella morganii cross reacting with yersinia enterocolitica. | two patients exhibited reactive arthropathy in association with chronic diarrhoea and abdominal pain. rising titres of agglutinating antibody to yersinia enterocolitica o3 were observed in association with arthropathy. morganella morganii was isolated from faeces of one patient in heavy growth. in both patients, absorption of the sera with morganella antigen abolished yersinia reactivity. morganella titres were more than 8 times the yersinia titres and were unaffected by absorption with yersinia ... | 1988 | 3194711 |
| [morphologic characteristics of bacteria treated with human blood serum and immunoglobulin]. | the electron microscopic study of ultrathin sections of bacterial cells treated with blood serum has revealed the presence of the immunoglobulin cover located on the cell wall and consisting of blood serum components. staphylococci (strain smith), studied with the use of ruthenium red, have been found to possess the capsule and the immunoglobulin cover located at its base. the immunoglobulin cover has proved to be more pronounced in gram-positive bacterial (actinomycetes, peptococci, staphylococ ... | 1988 | 3195266 |
| in vitro activities of pd 117,596 and reference antibiotics against 448 clinical bacterial strains. | the in vitro activity of pd 117,596, a new fluoroquinolone antibiotic, was tested against 448 bacterial isolates (15 genera) by agar dilution (inoculum, 10(4) cfu per spot). the activity of pd 117,596 was compared with that of 15 antibiotics against 327 gram-negative strains and with that of 8 other antibiotics against 121 gram-positive strains. pd 117,596 demonstrated the best activity against klebsiella spp., enterobacter spp., acinetobacter spp., serratia marcescens, and branhamella catarrhal ... | 1988 | 3196008 |
| [sensitivity to cephalosporin antibiotics of infectious causative agents in surgery]. | comparison of antimicrobial effects of cephalosporins of the 1st and 2nd generations showed that the latter were advantageous with respect to gram-negative bacteria causing surgical infections. three cephalosporins of the 3rd generation were characterized by the highest activity against such bacteria, including enterobacter spp. and indole positive strains of proteus spp., as well as non-enzymatic bacteria. the antimicrobial spectra and mics of the new cephalosporins with respect to the cultures ... | 1988 | 3196117 |
| [evaluation on the capability of indole pyruvic acid production by members of proteeae on different brands of sulfide-indole-motility]. | members of proteeae were vertically inoculated into different brands of sulfide-indole-motility (sim) medium for evaluating the capability of ipa production. a total of 328 clinical strains of tribe proteeae was used as tested organisms, including 186 proteus mirabilis strains, 62 morganella morganii strains, 31 proteus vulgaris strains, 27 providencia rettgeri strains, 14 providencia stuartii and 8 providencia alcalifaciens strains. seven different brands of sim medium used in this study are ky ... | 1988 | 3197461 |
| preparation of cultured and isolated cells for x-ray microanalysis. | various electron microscopical preparation techniques are compared with regard to the preservation of the intracellular element distribution as determined by x-ray microanalysis in scanning and scanning transmission electron microscopy. by use of chemical agents for fixation and dehydration ions are redistributed and washed out. this is also true for freeze-substitution. whole cells are prepared by cryofixation followed by freeze-drying. interference of intracellular measurements by extracellula ... | 1988 | 3201205 |
| case report 509: proteus syndrome. | | 1988 | 3201282 |
| [clinical laboratory approach for estimating effective administrative dose of cefuzonam. evaluation of disc susceptibility test and its interpretation system]. | in vitro activities of cefuzonam (czon) against 273 clinical isolates were studied through the evaluation of mic's and the results of disc susceptibility test. the mic's were determined using the agar dilution method at an inoculum level of 10(6)cfu/ml. the mic80's of czon against streptococcus pneumoniae, escherichia coli, klebsiella pneumoniae, proteus mirabilis, proteus vulgaris, haemophilus influenzae and citrobacter spp. were less than 0.20 microgram/ml. the mic80's against serratia marcesc ... | 1988 | 3204654 |
| [clinical laboratory approach for estimating effective administrative dose of cefoperazone. evaluation of disc susceptibility test and its interpretation system]. | to interpret of the cefoperazone (cpz) disc susceptibility test, a 4 category system is used in japan, but a 3 category system is used in the u.s.a. and europe. in the 4 category interpretation system of showa cpz disc the following classification is used: ( ) mic less than or equal to 3 micrograms/ml, (++) mic greater than 3 approximately 15 micrograms/ml, (+) mic greater than 15 approximately 60 micrograms/ml, (-) mic greater than 60 micrograms/ml. in the 3 category system the classification u ... | 1988 | 3204655 |
| in vitro activities of a-56619 (difloxacin) and a-56620, two aryl fluoroquinolones. | the in vitro activities of a56619 (difloxacin) and a-56620, two newer quinolones, have been compared with the activities of ciprofloxacin, ofloxacin, ceftazidime and netilmicin. a total of 782 clinical, bacterial isolates were employed. minimal inhibitory concentrations (mics) were determined under standard conditions with all isolates and, for 100 isolates against difloxacin and a-56620, with variation of agar ph and bacterial inoculum size. on a weight-for-weight basis, ciprofloxacin and a-566 ... | 1988 | 3208547 |
| in vivo antibacterial activity of fk482, a new orally active cephalosporin. | the therapeutic activities of orally administered fk482 were compared with those of reference antibiotics against systemic and local infections with a variety of bacteria in mice and rabbits. in systemic infections in mice, oral fk482 was almost as effective as oral cefaclor (ccl) and more effective than oral cephalexin (cex) against staphylococcus aureus, escherichia coli, klebsiella pneumoniae and proteus mirabilis infections. however, fk482 afforded superior protective activity when given sub ... | 1988 | 3209480 |
| [clinical laboratory approach for estimating effective administrative dose of sulbactam/cefoperazone]. | sulbactam/cefoperazone (sbt/cpz) is a preparation containing cpz and sbt, an inhibitor of beta-lactamases, at the ratio 1:1. the reliability of the sbt/cpz disc susceptibility test in estimating approximate values of mics and the utilization of the test in the evaluation of proper administrative doses were studied using 365 strains of clinical isolates. the antimicrobial activity of sbt/cpz was stronger than that of cpz alone. this increase in the antimicrobial activity due to the addition of sb ... | 1988 | 3210296 |
| [antibacterial activities of monobactams against fresh clinical isolates]. | antibacterial activities of monobactam antibiotics (carumonam (crmn) and aztreonam (azt] against gram-negative bacilli isolated from inpatients in the latter half of 1987 were investigated using penicillin (pc: piperacillin (pipc], cephems (ceps: ceftazidime (caz), cefotaxime (ctx), latamoxef (lmox), cefsulodin (cfs], carbapenem (imipenem (ipm] and pyridonecarboxylic acids (norfloxacin (nflx) and ofloxacin (oflx] as reference antibiotics. a total of 400 strains of 13 species, i.e. escherichia co ... | 1988 | 3210297 |
| [current resistance status of pathogens isolated from bile and its development since 1976 in the suhl district]. | bile was collected intraoperatively and through duodenal tubes from patients and was microbiologically investigated. e. coli and coliform bacteria were found to be the most common germs in bile, accounting for 51.6 per cent of all positive findings. streptococcus faecalis and proteus spec. increased remarkably to 17 per cent each. calculated antibiotic therapy was found to depend for good success on knowledge of the latest resistance rates of the most common germs. these were 67 per cent e. coli ... | 1988 | 3213295 |
| bacteriological and clinical evaluation of cefotetan in the treatment of severe infections in hospitalized patients. | the authors studied 302 hospitalized patients, 164 males and 138 females aged 15-88 years (average 66 years), with severe infections. cefotetan was administered to 278 of them at the dose of 1 or 2 g, b.i.d. or a single daily dose i.m. other patients [24] were treated with a continuous intravenous infusion of cefotetan (3 g daily in 5% dextrose). of these patients 121 were treated for urinary tract infections (uti); 114 for respiratory tract infections (rti); 41 for liver biliary duct infections ... | 1988 | 3215108 |
| pig bite injuries and infection: report of seven human cases. | six patients developed local infection after being bitten or gored by swine. wounding was often deep and occurred characteristically on the posterior aspect of the thigh. severity of infection varied from simple wound infection with discharge and slough to cellulitis and abscess formation; pathogens included haemolytic streptococci, pasteurellae, bacteroides sp., proteus sp. and escherichia coli and were usually isolated in mixed culture. a patient with pasteurella aerogenes infection appears to ... | 1988 | 3215292 |
| [antibacterial activity of gentamicin against clinical isolates in pediatrics]. | antibacterial activity of gentamicin (gm), along with activities of other aminoglycosides and beta-lactams, was studied against clinical isolates collected from pediatric patients during a period of may 1986-april 1987. 1. gm-resistance was noted in 22% of staphylococcus aureus, 6% of proteus vulgaris, 8% of morganella morganii, 40% of providencia spp., 6% of enterobacter spp., 14% of serratia marcescens, and 14% of pseudomonas aeruginosa isolates. no gm-resistance was observed with isolates of ... | 1988 | 3216475 |
| [in vitro synergy between cefotaxime and its main metabolite, desacetylcefotaxime]. | in vitro synergistic interaction between cefotaxime (ctx) and its main metabolite, desacetyl-cefotaxime (dctx), against 7 species of clinical isolates (23-27 strains per species) was examined. complete or partial synergy was noted with a 1:1 combination of ctx and dctx against 22-78% of the bacteroides fragilis, staphylococcus aureus, citrobacter freundii, pseudomonas cepacia and enterobacter cloacae isolates examined. antagonistic effects of the drugs appeared against 11% of proteus vulgaris an ... | 1988 | 3216482 |
| isolation of enterobacteria from diarrhoeic west african dwarf goats. | an investigation was undertaken to determine enterobacteriaceae from faecal swabs of west african dwarf goats suffering from diarrhoea in the nsukka area of anambra state, nigeria. in one academic year a total of 37 enteric bacteria were successfully recovered aseptically from 35 faecal swabs from caprine species. the predominant enterobacteria pathogens isolated from diarrhoeic goats and their relative percentage frequency of isolation were: 27 escherichia (73%), 7 proteus (19%) and 3 shigella ... | 1988 | 3216800 |
| in vitro activity of cefixime, a new oral cephalosporin. | the in vitro activities of cefixime and seven comparative oral antimicrobials were studied. mic90s of cefixime were 0.015-1 micrograms/ml for haemophilus influenzae, branhamella catarrhalis, escherichia coli, klebsiella, citrobacter diversus, proteus, providencia, aeromonas hydrophila and streptococcus. mic90s for other enterobacteriaceae were greater than or equal to 2 micrograms/ml; 44% of those strains were inhibited by less than or equal 1 microgram/ml. staphylococcus, psuedomonas aeruginosa ... | 1988 | 3219746 |
| a comparative study of the sugar composition of lipopolysaccharides isolated from vibrio cholerae, 'vibrio albensis' and vibrio metschnikovii. | a comparative study was made of the quantitative sugar composition of lipopolysaccharides (lps) isolated from vibrio cholerae (o1 and non o1 groups), 'v. albensis', 'v. proteus' and v. metschnikovii. the amino sugars 4-amino-4,6-dideoxy-d-mannose (perosamine) and 2-amino-2,6-dideoxy-d-glucose (quinovosamine) were present exclusively in lps isolated from s-form o1 group of v. cholerae regardless of serotype (i.e. ogawa or inaba) and biotype (i.e. classical or eltor). classical o1 group v. cholera ... | 1988 | 3221203 |
| [clinical laboratory approach in estimating the effective dosage of cefamandole]. | reliability of the cefamandole (cmd) disc susceptibility test in estimating approximate values of mics was studied using various clinical isolates totaling 246 strains with showa discs (8 mm diameter containing 30 micrograms of cmd). clinical significance of a 4 category system for the interpretation of the cmd disc tests, which is normally used in japan, was also evaluated to determine whether this system would be suitable or not for the evaluation of a proper dose of administration. the result ... | 1988 | 3221428 |
| [hemolytic-uremic syndrome in intestinal infections in infants]. | | 1988 | 3222102 |
| [the antibacterial effect of ciprofloxacin, ofloxacin and norfloxacin in vitro]. | mics of ciprofloxacin (cip), ofloxacin (ofl) and norfloxacin (nor) were assessed with a total of 523 strains of 7 species (spp) of enterobacteriaceae, various pseudomonads, methicillin-susceptible and -resistant s. aureus, l. monocytogenes, legionella species and c. difficile. in addition, the mbcs were assessed with s. aureus and e. coli. with break-points of less than or equal to 0.5 and greater than or equal to 4 mg/l all strains of e. coli, k. oxytoca, p. mirabilis and indole-positive proteu ... | 1988 | 3223134 |
| dissociation of membrane-cortex contacts in the hyalospheres of amoeba proteus exposed to light-shade differences. | the hyalospheres produced by a heat shock spontaneously separated successive sheets of the cortical actin layer from the plasma membrane and retracted them inward. this phenomenon was hampered or completely inhibited by 10(4) lux white light and restored in shade. the frequency of detaching the consecutive submembrane sheets was much higher in the shade than in full light. if the light-shade difference has been applied across a single hyalosphere, the detachment of cortical layer was initiated a ... | 1988 | 3224372 |
| in vitro activity of pefloxacin compared with five other quinolones on nalidixic acid-resistant proteae species. | the in vitro activity of pefloxacin, a new fluoroquinolone, was compared with that of 5 other quinolone compounds (nalidixic and pipemidic acids, norfloxacin, ciprofloxacin, and ofloxacin) against 416 strains of proteae spp. isolated from urine specimens of hospitalized patients with acute urinary tract infections (uti). ciprofloxacin was the most active agent. norfloxacin, ofloxacin, and pefloxacin were similarly active against proteus strains (mic90 = 0.39 microgram/ml). against providencia sp ... | 1988 | 3224396 |
| effect of pefloxacin on adherence of proteus-providencia spp to squamous epithelial cells. | pefloxacin, a new piperazinyl substituted quinolone derivative, reduced at sub-mics (minimal subinhibitory concentrations: four times lower than minimal inhibitory concentrations) the in vitro adherence of proteus-providencia spp. to squamous epithelial cells obtained from the urinary tract. the decrease of adherence was about 30% and 50% after 1 h and, respectively, 16-18 h of incubation with pefloxacin. this finding suggests that pefloxacin may play a role in determining the in vivo adhesion o ... | 1988 | 3224397 |
| [kidney morphology in hemolytic-uremic syndrome]. | morphology of the kidneys in hemolytic-uremic syndrome is considered basing on autopsy findings obtained for 3 infants with 5-17-day history of acute renal failure. a newborn infant of 17 days developed the disease after feto-fetal hemotransfusion when macerated fetus-donor hemolysis products entered the circulation of the fetus-recipient through monochorionic placenta. the second case in an infant of 6 months was due to adtp vaccine. the last infant aged 16 months manifested the syndrome in the ... | 1988 | 3233069 |
| behavioral evidence and supporting electrophysiological observations for electroreception in the blind cave salamander, proteus anguinus (urodela). | conditioning experiments revealed that proteus perceives a back-and-forth moving (approximately 1 hz) direct-current field and its polarity. minimum behavioral thresholds occurred at a current density of 0.15 microa/cm2, corresponding to a voltage gradient of 0.5 mv/cm. recordings from afferent nerve fibers showed that ampullary electroreceptors in proteus respond as do other nonteleost receptors, i.e. with an increase in discharge rate to cathodal current and a decrease to anodal current (thres ... | 1988 | 3233487 |
| proteus syndrome versus bannayan-zonana syndrome: a problem in differential diagnosis. | the proteus syndrome (ps) and the bannayan-zonana syndrome (bzs) both have multiple hamartomata as prominent features. hemihypertrophy, macrodactyly, exostoses, skin lesions, scoliosis, and sporadic occurrence are seen in ps, whereas patients with bzs have macrocephaly and related craniofacial findings. bzs has been observed in families as an autosomal dominant trait. although the two syndromes can be distinguished in most patients, there are features in common to both that may pose a diagnostic ... | 1988 | 3234431 |
| studies of metabolites in diarrheal stool specimens positive for klebsiella, serratia, and proteus spp. by frequency-pulsed electron-capture gas chromatography. | diarrheal stools from infants from which klebsiella pneumoniae, serratia liquefaciens, and proteus mirabilis were isolated as possible causative agents of diarrhea were studied. these stools, along with control stool specimens which were collected from infants in the same village of tamooh (near cairo, egypt), were analyzed by frequency-pulsed electron-capture gas chromatography (fpec-gc). watery stools and formed stools, to which distilled water was added, were centrifuged, and the supernatant ... | 1988 | 3235497 |
| boutonneuse fever transmitted by conjunctival inoculation. | we report three cases (two adult males and a 12-year-old child) of boutonneuse fever produced by inoculation of the conjunctival mucosa (probably through accidental entry of r. conorii fluid into the eyes through rubbing or splashing). all three patients developed similar symptoms of disease, including high fever, headache, maculopapular exanthem, and conjunctivitis, and none had tache noire. specific immunofluorescent antibodies appeared in these patients' serum mostly after the 2nd week; agglu ... | 1988 | 3236764 |
| [are cardiac glycosides advisable in the treatment of food poisoning]. | rheopolycardiological investigation of 76 patients with food toxinfections (fti) showed that phasic changes of systolic indices in these diseases developed as a result of extracardiac hemodynamic disorders and were of adaptive nature. strophanthin administration to 20 similar patients at the height of disease brought about no statistically significant changes in systolic indices. it was concluded that the use of cardiac glycosides was inappropriate for the treatment of fti. | 1988 | 3238582 |
| report of a case resembling the proteus syndrome with a chromosome abnormality. | | 1988 | 3239588 |
| in vitro susceptibility of bacteria to a ticarcillin-clavulanic acid combination. | in vitro testing of bacterial susceptibility to a combination of ticarcillin and clavulanic acid was done, using 406 aerobic gram-positive and gram-negative isolates (considered to be pathogens) cultured from equine and small animal specimens. a microdilution broth technique of susceptibility testing was performed, using trays with wells containing a range of doubling concentrations of dehydrated ticarcillin (range, 0.50 to 128 micrograms/ml) with fixed concentration of clavulanic acid (4 microg ... | 1988 | 3239838 |
| activity of cefixime (fk 027) for resistant gram-negative bacilli. | cefixime is an orally absorbable cephalosporin with an extended spectrum of in vitro activity for gram-negative bacteria especially members of the enterobacteriaceae. gram-negative rod isolates collected over a three month period were tested against cefixime. greater than 99% of escherichia coli isolates was susceptible to cefixime including those resistant to ampicillin. similarly isolates of klebsiella, proteus and providencia were also exquisitely susceptible to cefixime as were 91% of entero ... | 1988 | 3243091 |
| [rifampicin in the treatment of infections of non-tuberculous etiology]. | clinical efficacy of rifampicin, a semisynthetic broad spectrum antibiotic was estimated in 247 patients with purulent inflammations. it was shown advisable to use rifampicin intravenously in treatment of severe bronchopulmonary pathology, disorders of the bile excretion system, osteomyelitis, severe wound infections and in prophylaxis of postoperative purulent complications in cardiovascular surgery and other cases. high rifampicin sensitivity of staphylococci and streptococci belonging to vari ... | 1988 | 3245710 |
| [clinical studies on sultamicillin fine granule in pediatric field]. | pharmacokinetics, safety and effects on bacterial infection of sultamicillin (sbtpc) fine granule were evaluated in 17 children. the results obtained are summarized as follows. 1. pharmacokinetics in 3 children receiving a single dose of 10 mg per kg body weight were evaluated. the half-life of ampicillin (abpc) was 1.38 +/- 0.14 hours and that of sulbactam was 0.93 +/- 0.26 hour. 2. fourteen cases, including 7 tonsillitis, 2 pharyngitis, 2 bronchitis, and 1 each of cystitis, scarlet fever and c ... | 1988 | 3249370 |
| [the in vitro activity of ofloxacin, pefloxacin and ciprofloxacin against various gram negative bacteria isolated from urinary tract infections]. | in this study the in vitro activity of ofloxacin, pefloxacin and ciprofloxacin against various gram negative bacteria isolated from urinary tract infections was examined. of 80 isolates (24 e. coli, 10 enterobacter, 10 klebsiella, 23 proteus, 10 pseudomonas, 2 morganella and 1 serratia) 49 were from inpatients, and 31 were from outpatients. ciprofloxacin was the most potent compound and no resistant strain was found against ciprofloxacin, while 1 enterobacter strain and 1 pseudomonas strain were ... | 1988 | 3252111 |
| [causative agents of urinary tract infections and sensitivity to antibiotics]. | our study was done on the outpatients and inpatients of ankara numune hospital who were diagnosed as having urinary tract infections. when 301 cultures with positive results were evaluated. gram-negative bacteria were found most frequently (e. coli 45.2%, klebsiella 23.2%, enterobacter 16.6%, proteus 11.5%, s. aureus 2.2%, pseudomonas 1.3%). by using the disc diffusion method, the effectiveness of antibiotic discs of amikacin, tobramycin, netilmycin, cephoperazone, cephotoxime, cephtizoxime, cep ... | 1988 | 3252113 |
| [a new rapid antibiotic susceptibility test for enteric bacteria using a color change method]. | the rapid antibiotic susceptibility tests that have been developed so far cannot be used in daily work, because of their many difficulties and disadvantages. we have developed a new antibiotic susceptibility test for enteric bacteria which gives the result in 4 hours, easy to perform and inexpensive. this method depends upon the mechanism which detects the acid formed by the bacteria, by the change of the color of the ph indicator in the medium. the susceptibility of 110 different isolates of en ... | 1988 | 3252116 |
| [antibiotic-resistant microorganisms isolated from the urine of patients with suspected urinary tract infections]. | in our study 5331 urine specimen have been examined. in 22 of the total 2 types of bacteria have been isolated and in the cultures of 1167 patients colony counts over than 100.000/ml. have been determined. these are 599 escherichia coli, 161 hemolytic escherichia coli, 104 klebsiella, 93 proteus, 81 pseudomonas, 65 staphylococcus epidermidis, 44 staphylococcus aureus, 24 enterobacter, 18 enterococcus. 602 of the infected patients were women and 565 were men. according to antibiogram results micr ... | 1988 | 3252120 |
| [climate therapy and change in cellular immunity]. | the cell-mediated immunity was investigated by delayed hypersensitivity reactions on recall antigens (tetanus, diphtheria, streptococci, tuberkulin, candida, trichophyton, proteus/multitest-merieux) in 56 patients with atopic dermatitis (34 females, 22 males) under mountain-climatic therapy (davos, 5118 ft). the testscore of 7.9 mm (females 8.2/males 7.5) was lowered in comparison to the normals within the literature (females 15.4/males 21.0). anergy was found in 8.8% in females (normal 4%) and ... | 1988 | 3252623 |
| an evaluation of allozyme amino acid substitutions for the study of molecular relationships in providencia strains. | through analysis of molecular relationships in terms of amino acid substitutions, intra- and interspecies differentiations in providencia alcalifaciens, p. stuartii and p. rustigianii were evaluated among the electrophoretic variants of three enzymes, l-malate dehydrogenase, acid phosphatase and esterase-beta a, chosen for their distinct pattern of polymorphism. for each enzyme, molecular relatedness among variants defined by two-dimensional electrophoretic profiles was examined through protein ... | 1988 | 3252906 |
| occurrence, transfer and mobilization in epilithic strains of acinetobacter of mercury-resistance plasmids capable of transformation. | a 7.8 kb plasmid (pqm17) encoding mercury resistance was isolated from two epilithic strains of acinetobacter calcoaceticus. the plasmid had a broad host range when mobilized by rp1, transferring into pseudomonas aeruginosa, p. putida, p. fluorescens, escherichia coli, proteus vulgaris and chromobacterium sp. with frequencies ranging from 5.3 x 10(-9) to 4.6 x 10(-4) per recipient. the plasmid could be transferred into a. calcoaceticus bd413 using intact cells of donor and recipient bacteria (i. ... | 1988 | 3254940 |
| bmy-28100, a new oral cephalosporin: antimicrobial activity against nearly 7,000 recent clinical isolates, comparative potency with other oral agents, and activity against beta-lactamase producing isolates. | the antimicrobial activity of bmy-28100 was tested against approximately 7,000 bacterial pathogens in a multicenter, multiphased collaborative investigation. the bmy-28100 spectrum and antimicrobial potency was most similar to that of cefaclor and superior to that of cephalexin among currently available cephalosporins. species that had greater than or equal to 90% of clinical strains inhibited by bmy-28100 (less than or equal to 8.0 micrograms/ml) were: citrobacter diversus, escherichia coli, kl ... | 1988 | 3259489 |
| antibacterial activity in human urine of fosfomycin trometamol in an in vitro model of the urinary bladder. | the urinary concentrations of fosfomycin trometamol, norfloxacin, pipemidic acid and cotrimoxazole were studied at various times after oral administration of drugs in healthy volunteers. using the same urine, the bactericidal activity of four antimicrobial agents against escherichia coli, proteus mirabilis and klebsiella pneumoniae in an in vitro model simulating the treatment of bacterial cystitis was also evaluated. the results obtained show that very high concentrations of the drugs were achi ... | 1988 | 3259909 |
| treatment of experimental cystitis in the rat with a single dose of fosfomycin trometamol. | the therapeutic effectiveness of a single oral dose (60 and 200 mg/kg body weight) of fosfomycin trometamol (ft), norfloxacin, trimethoprim sulfamethoxazole (bactrim) and pipemidic acid against experimental cystitis in the rat were compared. infections were produced with clinical isolates of klebsiella pneumoniae, proteus mirabilis and escherichia coli in a total of 135 sprague-dawley albino rats. oral treatment with all four drugs consistently lowered the numbers of cfu in bladder tissue, espec ... | 1988 | 3259910 |
| in vitro activity of an oral iminomethoxy aminothiazolyl cephalosporin, r-3746. | the in vitro activity of r-3746, an iminomethoxy aminothiazolyl cephalosporin with a ch2och3 moiety at position 3, was compared with those of other antibiotics. r-3746 inhibited the majority of hemolytic streptococci (groups a, b, c, f, and g) and streptococcus pneumoniae at less than 0.06 micrograms/ml, which was comparable to the activity of amoxicillin, 2- to 8-fold more active than cefixime, and 16- to 64-fold more active than cefaclor and cephalexin. ninety percent of beta-lactamase-produci ... | 1988 | 3260766 |
| comparable evaluation of orally active beta-lactam compounds in ampicillin-resistant gram-positive and gram-negative rods: role of beta-lactamases on resistance. | the antibacterial activity of the recently developed cephems cefixime and cefetamet-pivoxyl was evaluated in 408 gram-positive and gram-negative rods, all isolated recently from clinical specimens, and compared to that of other orally active agents such as ampicillin, amoxycillin + clavulanic acid, cefaclor, cefuroxime-axetil and to ceftriaxone. with regard to ampicillin-resistant enterobacteriaceae ceftriaxone proved to be the most active agent, followed by cefixime and cefetamet, whereas cefur ... | 1988 | 3262045 |
| in-vitro activity and beta-lactamase stability of ly163892. | ly163892 is a new orally absorbed carbacephem. it inhibited streptococcus pyogenes and str. pneumoniae at less than or equal to 1 mg/l, but was less active against group b streptococci and groups c, f, g and bovis streptococci with mics of 1 to 2 mg/l for most but as high as 8 mg/l for some isolates. mic90 of methicillin-susceptible staphylococcus aureus was 8 mg/l, but greater than 128 mg/l for methicillin-resistant staphylococci. ly163892 had activity similar to cefaclor and cephalexin with mi ... | 1988 | 3263352 |
| activity of temocillin and other penicillins against beta-lactamase-inducible and -stably derepressed enterobacteria. | mics of temocillin, carbenicillin, ticarcillin, mezlocillin, piperacillin and ampicillin were determined for mutant series of enterobacter cloacae, citrobacter freundii, proteus vulgaris, morganella morganii and serratia marcescens with inducible, stably derepressed or basal expression of chromosomal class i beta-lactamases. ampicillin was inactive (mic greater than 256 mg/l) both against beta-lactamase-inducible organisms (except c. freundii) and their stably derepressed mutants, whereas basal ... | 1988 | 3263354 |
| simple assay of beta-lactamase with agar medium containing a chromogenic cephalosporin, pyridinium-2-azo-p-dimethylaniline chromophore (padac). | a new beta-lactamase assay method with agar plates containing pyridinium-2-azo-p-dimethylaniline chromophore (padac) (50 microm), a beta-lactamase-labile, chromogenic cephalosporin, was examined. on the padac plates inoculated with beta-lactamase-producing gram-negative bacteria (10(4) cfu per spot) and incubated at 37 degrees c, a yellow zone showing hydrolysis of padac by beta-lactamase was formed around the colony. the zone diameter increased with incubation time. examination with enterobacte ... | 1988 | 3263833 |
| in vitro activity of the combination trimethoprim plus sulfamethoxazole compared with that of other chemotherapeutic agents. | for many years now, the combination trimethoprim plus sulfamethoxazole (active ingredients of bactrim) has proved to be an effective chemotherapeutic agent with a broad spectrum of antibacterial activity against both gram-positive and gram-negative organisms, including beta-hemolytic streptococci, staphylococci, pneumococci, haemophilus influenza, escherichia coli, proteus mirabilis, proteus vulgaris, klebsiella, enterobacter and citrobacter. in this comparative study, the antibacterial activity ... | 1988 | 3264166 |
| in vitro antibacterial activity of fk482, a new orally active cephalosporin. | fk482 is a new orally active cephem antibiotic which offers some advantages over the commercially available oral beta-lactam antibiotics. it displayed a broad spectrum of activity in vitro against stock strains of gram-positive and gram-negative aerobes and anaerobes. fk482 was more active in vitro than cefixime (cfix), cefaclor (ccl) or cephalexin (cex) against clinical isolates of gram-positive organisms such as methicillin-sensitive staphylococcus aureus, coagulase-negative staphylococci incl ... | 1988 | 3264828 |
| [urine bacterial flora and chemoantibiotic resistance: observations on ambulatory patients and hospitalized patients at the local health district no. 11 of fabriano (ancona)]. | this paper reports the results of a study carried out on 4614 samples of urine from inpatients and outpatients according to the sex. the positive monomicrobic urine specimens were examined and isolated strains were tested against various antimicrobial drugs. our findings showed that 43.1% of urine specimens examined from inpatients and 38.4% from outpatients proved to be positive. among the bacterial species more frequently isolated, significant differences among enterobacter spp. in males and c ... | 1988 | 3268917 |
| [aerobic and anaerobic bacterial flora of crural ulcers]. | in a group of 600 patients treated in the metropolitan dermatological hospital in warsaw bacteriological examination were carried out of swabs from the untreated crural ulcers. in 95% of these cultures growth of pathological aerobic organisms was obtained. coagulase-positive staphylococci (st. aureus) and gram-negative bacteria (pseudomonas aeruginosa, proteus vulgaris, enterobacter sp and e. coli) prevailed. in 27% of cases the cultured strains were resistant to the generally available antibiot ... | 1988 | 3268941 |
| killing of proteus mirabilis by polymorphonuclear leukocyte granule proteins: evidence for species specificity by antimicrobial proteins. | low-molecular-weight (mr, ca. 3,800) polypeptides containing human defensins hnp-1 and hnp-2 (t. ganz, m. s. selsted, d. szlarek, s. l. harwig, k. daher, d. f. bainton, and r. i. lehrer, j. clin. invest. 76:1427-1434, 1985) prepared in our laboratory from acid extracts of human polymorphonuclear granulocyte granules and purified human defensins were found to exert potent bactericidal action against proteus mirabilis. the antimicrobial action of the extracts of human polymorphonuclear leukocytes ... | 1988 | 3275586 |
| production and properties of haemolysins from clinical isolates of the proteeae. | a collection of 198 clinical isolates of strains belonging to the tribe proteeae was examined for haemolytic activity on blood agar and in brain heart infusion broth. the strains were of diverse bacteriocin and o-antigenic types and from a wide variety of sources. they included representatives of all species of morganella, proteus and providencia. approximately half of the m. morgani strains were haemolytic on blood agar. this activity was not associated with any particular bacteriocin type. the ... | 1988 | 3275780 |