Publications

[otogenic brain abscess with rupture into the lateral ventricle].	we present a case of otogenic abscess of the brain that ruptured into the ipsilateral cerebral ventricle. all the diagnostic, surgical and postoperative procedures which led not only to saving this patient but also his complete recovery are described. because there is a great difference between rupture of a cerebral abscess into a ventricle and rupture of the ventricle into an abscess, particularly with reference to the prognosis, the pathology of the two different complications is reviewed, bas ...	1989	2668239
eswl monotherapy for large-volume renal calculi: efficacy and morbidity.	we assessed the efficacy and morbidity of extracorporeal shock-wave lithotripsy (eswl) monotherapy in the treatment of 25 consecutive patients with large-volume renal calculi (surface area greater than or equal to 5.0 cm2). eighteen of the calculi were infection (struvite) stones and 7 were sterile stones. in 21 cases internal ureteral stents were positioned before eswl, but no patient underwent pretreatment percutaneous nephrostomy (pcn) or percutaneous nephrostolithotomy (pnl). an average of 2 ...	1989	2669309
resistance to gentamicin and amikacin of gram-negative organisms isolated from horses.	resistance of gram-negative bacteria to gentamicin has become an increasingly common problem among clinical isolates from human beings. susceptibility of isolates from horses to gentamicin and amikacin was evaluated for the period from july, 1983 to june, 1985. all isolates of escherichia coli, and species of enterobacter, klebsiella, proteus, and pseudomonas examined were susceptible to amikacin, except 2 of the 46 pseudomonas isolates. in contrast, 13 to 50% of isolates were resistant to genta ...	1989	2669575
interstitial cystitis and the urethral syndrome: a possible answer.	a study was made of 20 patients fulfilling the criteria customarily used for the diagnosis of interstitial cystitis. a possible infective aetiology was sought by culture of bladder tissue, catheter and midstream specimens of urine, and urethral swabs by methods capable of detecting fastidious bacteria as well as aerobic pathogens. all bladder biopsies showed the histological appearances usually associated with interstitial cystitis, and bacteria were isolated from the catheter specimens and/or b ...	1989	2670041
third generation cephalosporins.	the third generation cephalosporins demonstrate greater potency, broader antibacterial spectrum, and more favorable pharmacologic characteristics than other cephalosporins. the majority of strains of e. coli, klebsiella pneumoniae, and proteus are susceptible, including strains resistant to aminoglycosides, anti-pseudomonas penicillins, and other cephalosporins. pseudomonas aeruginosa is susceptible to a subgroup of third generation agents including ceftazidime, cefoperazone, and the experimenta ...	1989	2671141
[brain abscess following cerebral infarction: a case report].	the authors report a case of brain abscess following cerebral infarction. a 73-year-old man was admitted to our clinic with symptoms of right hemiparesis and total aphasia. ct scan revealed abnormal low density area in the left fronto-temporo-parietal region. cerebral angiography demonstrated occlusion of the left middle cerebral artery at the m1 portion. on the 16th hospital day, an episode of generalized seizure with high fever appeared, and intermittent high fever persisted thereafter. two mo ...	1989	2671775
the core region of proteus mirabilis r110/1959 lipopolysaccharide.	the complete core structure present in the lipopolysaccharide of the r mutant r110/1959 from proteus mirabilis (proteus type ii core) was investigated using methylation analysis and a number of degradation methods such as smith degradation and beta-elimination. these studies combined with earlier work on a rc-type mutant of p. mirabilis o28 (r4/o28) which shares the same inner core region, allowed formulation of the complete core structure of the proteus type ii core as shown in scheme 1. (formu ...	1989	2673779
proteeae species bacteriuria accompanying proteeae species groin skin carriage in geriatric outpatients.	there have been numerous reports of proteeae species urinary tract infections among elderly individuals. to explore a possible urinary carrier source of proteeae species in this population, the frequency of aerobic gram-negative bacillus (agnb) bacteriuria at the greater than or equal to 10(2)/ml level was determined in 67 ambulatory elderly outpatients classified as to proteeae group (morganella, proteus, providencia) groin carriage by a set of two skin cultures obtained at least 1 week apart. ...	1989	2674195
[frequency of germ isolation from urinary infections in community practice; their sensitivity to 7 antibiotics including a combination of amoxicillin and clavulanic acid. evaluation on 1611 samples].	a multicenter study including 10 outpatient private laboratories (hospital laboratories excluded) was carried out in france. 1,611 urines samples from patients with uti were collected during the forth trimester of 1987. the most frequently recovered pathogens were: e. coli (71%), proteus mirabilis (9%), staphylococcus coagulase (6%), klebsiella (6%), enterobacter (2%). other sorts (streptococcus d, proteus sp, pseudomonas aeruginosa, enterobacter sp) were infrequent (less than 1%). the sensitivi ...	1989	2674870
potencies of ceftriaxone and cefotaxime in a single chamber pharmacokinetic system simulating their in vivo half-lives.	ceftriaxone and cefotaxime are third-generation cephalosporins with similar in vitro potencies and spectra. however, previous studies have shown that ceftriaxone had superior in vivo activity (mouse pd50 values greater than or equal to 2-fold lower) compared to cefotaxime in 23 of 46 tested enterobacteriaceae. this superior activity was thought to be due to ceftriaxone's 5- to 8-fold longer half-life. the relationship between half-life (ceftriax-one 6 h, cefotaxime 1 h) and potency was examined ...	1989	2676404
a case of hypomagnesemia hypocalcemia as a complication of aminoglycoside and review of the literature.	a 28-year-old woman was admitted to the ent department of the faculty of medicine, chiang mai university because of left otitis externa, chronic mastoiditis and facial nerve palsy (lower motor neurone). left radical mastoidectomy with wide debridement of granulation and necrotic tissue at ear canal, dura, sigmoid sinus, ossicle and facial nerve were done two weeks after admission. multiple pus culture from the lesion revealed different types of organisms e.g. proteus mirabilis, beta strep non gr ...	1989	2677207
morphological lesions of the rat urinary tract induced by inoculation of mycoplasmas and other urinary tract pathogens.	the effects on the urinary tract after inoculation of ureaplasma urealyticum into the rat bladder were evaluated and compared to that seen after mycoplasma hominis, escherichia coli and proteus mirabilis inoculation. the inoculation of the urease-producing organisms p. mirabilis and u. urealyticum were associated with the formation of struvite bladder stones and predominantly hyperplastic lesions of the bladder. the p. mirabilis inoculated rats also displayed marked pyelonephritis. a similar but ...	1989	2678669
a spectrin-like protein present on membranes of amoeba proteus as studied with monoclonal antibodies.	monoclonal antibodies against a spectrin-like membrane-associated protein of xd amoebae. (amoeba proteus) were used to determine the distribution of the protein and some of its characteristics. a total of 34 monoclonal antibodies recognizing different epitopes of the protein were obtained, of which seven stained cell membranes by indirect immunofluorescence. the spectrin-like protein had two subtypes of 225 and 220 kda and several monoclonal antibodies cross-reacted with human erythrocyte spectr ...	1989	2680538
therapeutic activity of meropenem in experimental infections.	meropenem and comparative antibiotics were evaluated in five models of infection. all antibiotics were administered parenterally; imipenem was used in combination with cilastatin but meropenem and other agents were given alone. generalized infections in mice caused by staphylococcus aureus, streptococcus pneumoniae, escherichia coli, serratia marcescens, proteus mirabilis or pseudomonas aeruginosa all responded to low doses of meropenem or imipenem. immunocompromised mice infected with ps. aerug ...	1989	2681126
in-vitro activity of meropenem against clinical isolates in a multicentre study in italy.	a multicentre in-vitro study was undertaken to evaluate the susceptibility of bacterial pathogens isolated in different italian hospitals to meropenem. a total of 1399 aerobic and 452 anaerobic strains was analysed. comparative agents were imipenem, cefotaxime, ceftazidime, ceftriaxone, piperacillin, ciprofloxacin, gentamicin, amikacin, plus vancomycin when appropriate. the mic ranges (mg/l) of meropenem were: 0.015-2 for klebsiella spp., proteus spp., morganella morganii and providencia spp.; l ...	1989	2681128
growth curve patterns of escherichia coli, serratia marcescens, and proteus vulgaris submitted to different tigemonam concentrations.	five strains of escherichia coli, serratia marcescens, and proteus vulgaris were exposed to a new monobactam, tigemonam, in comparison with aztreonam. the study, evaluated by kinetic turbidimetry, has shown that tigemonam exerts a prelytic increase in optical density (od) similar to that of other beta-lactam antibiotics. the maximal value of the prelytic increase in od was similar for the two study antibiotics at concentrations of 1, 2, 4, and 8 times the minimum inhibitory concentration, corres ...	1989	2681561
[pharmacokinetic and clinical studies on cefpodoxime proxetil dry syrup in the field of pediatrics].	cefpodoxime proxetil (cpdx-pr, cs-807) is a new oral cephem derivative drug in which carboxylic acid was esterified to the 4-position of cpdx (oxime type cephem antibiotic). cpdx-pr is hydrolyzed mainly with esterase in intestinal wall and cpdx exists as an active form in body fluid. while there are numerous study reports using cpdx-pr in tablet forms in japan, the dry syrup formula for pediatric use was newly developed. the dry syrup of cpdx-pr was orally administered 20 minutes after meal to t ...	1989	2681864
[food poisoning complicated by septicemia].		1989	2681983
[duration of the preventive use of antibiotics in colorectal surgery--single administration versus short-term prevention].	the effect of a combination of 4 g mezlocillin and 0.5 g metronidazole for the prophylaxis against infections in a one-shot dose immediately preoperatively compared to a short-time dose of 2 days given to 90 patients with resection of colorectal carcinoma was investigated in a prospective and randomized study. 6 patients developed a wound infection in the early postoperative phase; 4 of these infections (3 were severe, 1 was mild) occurred in the one-shot group and 2 in the short-time prophylaxi ...	1989	2682096
formation of perinephric abscess following extracorporeal shock-wave lithotripsy.	we report 2 cases of perinephric abscess formation following extracorporeal shockwave lithotripsy (eswl). possible mechanisms and preventative measures are discussed.	1989	2683324
pyridoxal 5'-phosphate dependent histidine decarboxylase: overproduction, purification, biosynthesis of soluble site-directed mutant proteins, and replacement of conserved residues.	the hdc gene coding for the pyridoxal 5'-phosphate dependent histidine decarboxylase from morganella morganii has been expressed in escherichia coli under control of the lac promoter. the enzyme accumulates to 7-8% of total cell protein and is purified to homogeneity by passage through three columns. fourteen site-directed mutant enzymes were constructed to explore the roles of residues of interest, especially those in the sequence ser229-x230-his231-n epsilon-(phosphopyridoxylidene)lys232, sinc ...	1989	2684275
[the antibiotic resistance of pathogens from fecal samples].		1989	2684761
near-fatal complications of tracheotomy infections and their prevention.	infectious complications of tracheotomy range from minor to potentially fatal. three cases are presented: clavicular osteomyelitis; innominate artery blowout with mediastinitis; and the first reported case of necrotizing fasciitis involving the chest wall related to tracheotomy infection. all patients were debilitated, with one diabetic and another steroid-dependent. infectious sequelae occurred as late as 8 weeks following tracheotomy. the mechanism, treatment, and prevention of tracheotomy inf ...	1989	2684907
nonculture detection of haemophilus influenzae in sputum with monoclonal antibodies specific for outer membrane lipoprotein p6.	isolation of haemophilus influenzae from sputum is hampered by overgrowth by other microorganisms or by antibiotic treatment of the patient. to overcome this problem in the detection of h. influenzae, an in situ immunoperoxidase staining technique was developed with monoclonal antibody (mab) 8bd9, immunoglobulin subclass g2a. mab 8bd9 appeared to be directed to an epitope on the outer membrane lipoprotein p6 of h. influenzae. the species specificity of mab 8bd9 was analyzed by staining isolates ...	1989	2685026
[hemagglutinating properties of proteus mirabilis strains isolated from clinical specimens].	haemagglutinating properties of 345 p. mirabilis strains isolated from various clinical samples were determined. red blood cells of different origin as human group 0, bovine, horse, sheep and rat were used for the study. for the detection of ms and mr/p haemagglutinins the haemagglutination reaction was run with and without d-mannose. on the other hand, for the detection of type mr/k haemagglutinins tanned human and bovine erythrocytes were used. the majority of tested strains (90.14%) was polyh ...	1989	2685483
[isolation and various characteristics of tryptophan deaminase from proteus vulgaris].	tryptophan deaminase was isolated from proteus vulgaris and purified. the procedure for enzyme purification included the cell destruction on usd-1, fractionation by ammonium sulphate, gel chromatography on ultragel aca34, ion exchange chromatography on deae-cellulose. a degree of the enzyme purification--95, yield--5.7%. the ph optimum was 7.5, the temperature optimum--47 degrees c. the enzyme molecular weight (105 kd) was estimated by gel chromatography on sephadex g-200, km--5.0 mm in the k-ph ...	1989	2686139
[experimental study of a new biological preparation for treating e. coli infection and proteus dysbacteriosis in young infants].	the action of a new biological preparation intended for the treatment of e. coli infection and proteus dysbacteriosis in children has been studied in experiments on mice and suckling rabbits. the protective activity of anti-e. coli and anti-proteus lactoglobulin has been found to exceed that of normal lactoglobulin 6- to 13-fold. when subjected to the action of proteolytic enzymes of the gastrointestinal tract, the preparation retains its preventive properties on the level of the native preparat ...	1989	2686305
randomized, double-blind comparative study of intravenous ciprofloxacin versus ceftazidime in the treatment of serious infections.	we compared intravenously administered ciprofloxacin with ceftazidime in a randomized, double-blind study. patients received ciprofloxacin 200 mg intravenously every 12 hours or ceftazidime 2 g intravenously every eight hours, with placebo infusions to maintain blinding. therapy with metronidazole was added for suspected or documented intra-abdominal infection. thirty-two of the 57 ciprofloxacin-treated patients were evaluable for determination of efficacy and had 41 bacterial isolates from 34 s ...	1989	2686416
intravenous ciprofloxacin and ceftazidime in serious infections. a prospective, controlled clinical trial with third-party blinding.	oral ciprofloxacin has been shown to be effective in the treatment of infections due to gram-positive cocci and gram-negative rods. the efficacy and safety of intravenous ciprofloxacin was compared with that of intravenous ceftazidime in the treatment of 59 patients with well-documented serious infections in a prospective, controlled, randomized study with a third-party blinding. thirty-three patients were treated with intravenous ciprofloxacin (200 mg every 12 hours, plus a daily extra placebo ...	1989	2686425
[perinephric phlegmon. current aspects of diagnosis and treatment. apropos of 20 cases].	the authors report a series of twenty patients presenting with perinephric abscess. percutaneous management was performed in 4 cases. considering the benefit of the modern imaging techniques, the authors discuss the current diagnostic, therapeutic and prognostic modalities of this disease.	1989	2686539
intravenous sulbactam/ampicillin in the treatment of pediatric infections.	a total of 82 patients involving 83 episodes of proven or presumed bacterial infection were treated with sulbactam/ampicillin. these included 36 cases of soft tissue infection or abscess, four cases of joint or bone infection, 20 cases of respiratory tract infection (17 cases of pneumonia, two of otitis media, and one of tonsillitis), 15 urinary tract infections, three cases of enterocolitis, one case of infective endocarditis, two cases of septicemia, and two of peritonitis. the causative patho ...	1989	2686918
structure of proteus mirabilis o27 o-specific polysaccharide containing amino acids and phosphoethanolamine.	the following structure of the repeating unit of the o-specific polysaccharide of proteus mirabilis o27, containing amides of d-glucuronic and d-galacturonic acids with l-lysine and l-alanine, respectively, n-acetyl-d-glucosamine and phosphoethanolamine, has been determined: (sequence; see text) the main methods used for structural analysis of the polysaccharide were selective solvolysis with anhydrous hydrogen fluoride and smith degradation, as well as nmr spectroscopy and mass spectrometry. th ...	1989	2686990
proteus mirabilis urease: nucleotide sequence determination and comparison with jack bean urease.	proteus mirabilis, a common cause of urinary tract infection, produces a potent urease that hydrolyzes urea to nh3 and co2, initiating kidney stone formation. urease genes, which were localized to a 7.6-kilobase-pair region of dna, were sequenced by using the dideoxy method. six open reading frames were found within a region of 4,952 base pairs which were predicted to encode polypeptides of 31.0 (ured), 11.0 (urea), 12.2 (ureb), 61.0 (urec), 17.9 (uree), and 23.0 (uref) kilodaltons (kda). each o ...	1989	2687233
detection by light microscopy of candida in thin sections of bladder stone.	we detected fungi morphologically resembling candida albicans in an infected bladder stone by light microscopy of thin sections. the fungi were found in the layers precipitated with oxalate crystals and were invading the interstices surrounded with apatite or struvite crystals as in tissue infection. this presumably represents a superimposed infection due to changes in flora following treatment with antibiotics.	1989	2688263
a comparative evaluation of oral ofloxacin versus intravenous cefotaxime therapy for serious skin and skin structure infections.	in a single-blind, placebo-controlled randomized trial, 100 successive patients were enrolled with serious skin and soft-tissue infections, whose illnesses had precipitated an initial hospital admission or an extension of inpatient care. there were 93 evaluable patients who received either ofloxacin, 400 mg orally every 12 hours plus an intravenously administered placebo every eight hours, or cefotaxime, 2.0 g intravenously every eight hours plus an orally administered placebo every 12 hours. th ...	1989	2690621
[comparative studies on activities of antimicrobial agents against causative organisms isolated from urinary tract infections (1986). i. susceptibility distribution].	susceptibilities to various antibacterial and antibiotic agents of bacterial strains isolated from urinary tract infections at 8 hospitals in japan from july to october in 1986 are summarized as follows. 1. enterococcus faecalis was susceptible to sulfamethoxazole/trimethoprim (st) and imipenem (ipm) with mic90s of 0.78 and 1.56 microgram/ml. minocycline had the strongest activity against staphylococcus aureus; the mics for all strains tested were lower than 0.39 microgram/ml. the mic80s of dicl ...	1989	2691714
rheumatoid arthritis and proteus: a possible aetiological association.	the presence of specific anti-proteus antibodies in active, rheumatoid arthritis (ra) patients, has been demonstrated by four different techniques: indirect bacterial agglutination, elisa, western blotting and immunofluorescence. furthermore, anti-hla-dr4 tissue typing sera have been shown to bind to proteus microorganisms, thereby suggesting some molecular similarity or cross-reactivity between bacteria and hla antigens. the concept is proposed that proteus-reactive arthritis occurs during acti ...	1989	2692130
the role of proteae in diarrhea.	a survey was undertaken on the occurrence of protease in the human fecal flora and its coincidence with other well-documented enteropathogens such as campylobacter, salmonella, shigella, staphylococcus aureus, yersinia, protozoa and rotavirus. a total of 2000 fecal specimens was investigated, 1000 from patients suffering from diarrhea and 1000 from healthy persons which served as controls. proteus mirabilis was isolated more frequently from diarrhea cases than from healthy people. the difference ...	1989	2692584
novel shuttle vectors for improved streptokinase expression in streptococci and bacterial l-forms.	novel shuttle vectors of small size and increased copy number capable of replication in escherichia coli, l-forms of proteus mirabilis, and streptococci were constructed from a streptococcal erythromycin-resistant plasmid and an escherichia coli phasmid. the streptokinase gene, skc, was inserted into one of them, and skc expression was studied in streptococcus sanguis, streptococcus lactis, and in an l-form strain (lvi) of proteus mirabilis. the new streptokinase shuttle plasmid, pmls10 (7.3 kb) ...	1989	2693202
[the characteristics of the chemical composition and biological activity of proteus antigens isolated using hydroxylamine].	the comparative study of the chemical composition and biological properties of antigens isolated from proteus vulgaris with the use of hydroxylamine and by two classical methods (boivin's and westphal's methods) has been made. as shown in this study, the treatment of bacteria with hydroxylamine makes it possible to obtain antigenic complexes with lower toxicity. at the same time hydroxylamine produces no denaturing effect on lipopolysaccharides and protein fractions of bacterial cells.	1989	2694690
[cytogenetic control over the safety of merthiolate].	the capacity of merthiolate (also known as thimerosal), a mercury organic compound used as preservative in vaccines, to induce chromosomal aberrations was studied in vivo in experiments on mice. the metaphasic method of the registration of anomalies was used. in a dose of 3.3 micrograms/kg body weight merthiolate did not produce a damaging effect on the chromosomes of marrow, spleen and embryonal liver cells. cyclophosphamide (in a dose of 25-50 micrograms/kg) used as positive control induced a ...	1989	2694694
[treatment of female acute cystitis with a single dose of cefminox].	thirty six female patients with acute cystitis were treated with one shot intravenous injection of 1 g cefminox. clinical efficacy was evaluated based on extent of subjective symptoms, pyuria and bacteriuria. of 36 patients, an excellent efficacy was shown in 32 cases, moderate in 3 cases and poor in 1 case. this poor case was diagnosed as complicated urinary tract infection because of right vesicoureteral reflux. therefore, the overall effectiveness rate of this treatment for acute uncomplicate ...	1989	2694837
[relationship between bacterial envelope barrier and resistance of e. coli, s. aureus to rifamdine].	the rifamdine (rfd) resistant strains were obtained from wild types of s. aureus nctc 6571, e. coli nctc 10418 and proteus vulgaris by drug concentration gradient plate. the experiment indicated that the growth inhibition of resistant cells induced by synergism of edta acting with rfd. such results did not occur effectively if edta or rfd was added separately. the amount of 3h-rfd incorporated into cells of susceptible and resistant strains of e. coli and s. aureus was compared. the amount of 3h ...	1989	2696722
aminoglycoside resistance patterns in clinical isolates of e. coli and klebsiella sp. from czechoslovakia and the united states.	resistance of gram-negative bacilli to aminoglycoside antibiotics differs by region and country. previous studies have demonstrated predominance of the nucleotidyltransferase anl(2") as the mechanism of enzymatic resistance to gentamicin in the united states and many european countries (federal republic of germany, switzerland, greece, turkey) whereas the acetylating enzymes aac(6') and aac(3) were the principal causes of resistance to aminoglycosides in japan and chile. in the present compariso ...	1989	2696761
[evaluation of antibacterial action and synergistic effect of copper sulfate and antibiotics in respect to the main causative agents of chronic pyelonephritis in children].		1989	2697848
late bacterial endophthalmitis following retinal detachment surgery.	we report two cases of late postoperative bacterial endophthalmitis that occurred following retinal detachment repair. both patients presented months after their scleral buckling procedures with a subacute uveitis. over a period of one to two weeks, the inflammation gradually increased, until the classic clinical appearance of fulminant bacterial endophthalmitis was present. in an effort to treat the infection, a pars plana vitrectomy was performed in both cases. at the time of vitreous surgery, ...	1989	2697917
[nitrate and nitrite in the urine, saliva and blood of urologic patients].	nitrate and nitrite contents were determined in urine, saliva, and blood of 298 patients suffering from urological diseases. crude values of nitrate and nitrite in morning urine without any correction due to density and creatinine are sufficient for epidemiological purposes. significant correlations exist with vegetables intake and bacteriuria, but not with age, sex, disease, smoking, and medicaments. neither nitrate nor nitrite may be considered to be general indicators of inflammatory processe ...	1989	2698023
[acetylhydroxamic acid in the treatment of nephrolithiasis, caused by infection with urease forming microorganisms].	acetohydroxam acid (500-1000 mg/d) inhibit the activity of the bacterial urease successfully due to reduction of ammonia excretion and urinary ph value in the patients. acetohydroxam acid should be used in patients after operative treatment of urolithiasis due to infection with carbamidesplitting bacteria.	1989	2698024
[the detection of a choleriform thermolabile enterotoxin in clinical strains of proteus isolated in different infections].	the capacity of proteus strains, isolated from patients with purulent inflammatory, urological and enteric infections, for the production of choleriform thermolabile enterotoxin was studied by means of the enzyme immunoassay (eia) with the use of antitoxic serum to escherichia coli enterotoxin. out of 125 strains, 27 (21.6%) showed the capacity for producing choleriform thermolabile enterotoxin in eia experiments. the results thus obtained indicate that eia techniques can be used, in principle, ...	1989	2698026
escherichia coli molybdoenzymes can be activated by protein fa from several gram-negative bacteria.	six gram-negative bacteria (klebsiella pneumoniae, erwinia chrysanthemi, proteus vulgaris, serratia marescens, salmonella typhimurium, and pseudomonas aeruginosa) were shown to contain an fa-type protein capable of activating aponitrate reductase, apotrimethylamine n-oxide reductase and apoformate dehydrogenase of escherichia coli. protein fa activity was highest in erwinia chrysanthemi and lowest in pseudomonas aeruginosa. all the species also contained the low-mr (less than or equal to 1500) h ...	1989	2699894
brain abscess as a cause of infant hydrocephalus. case report.	the authors report on a case of hydrocephalus caused by brain abscess in a four-months-old girl. after repeated punctures and antibiotics administration extirpation of abscess was necessary. the child recovered with only slight neurological deficit.	1989	2701913
bacteriology of infected hands and feet in leprosy patients.	70 cases of infected hands and feet admitted to alert hospital during 1986/1987 (3/10/86-5/5/87) were studied for the infecting organisms and the sensitivity of these organisms to available antibiotics. single organisms were isolated in 56 cases (95%), two organisms were isolated in 3 cases (5%), no organisms were isolated in 11 cases (15.7%). proteus was the commonest organism. most effective drug was ampicillin. three organisms isolated in 7 cases proved resistant to all drugs tested. the stud ...	1989	2703746
a unilateral mesenchymal disorder of the head.	a hitherto undescribed group of lesions consisting of cystic bony lesions, exostosis, fibromatous lesion, unilateral tonsillar hypertrophy, epidermoid cyst (cholesteatoma) and hyperplasia of the mandible confined to the left side of the face is reported. the case may represent a variant of the proteus syndrome.	1989	2708537
the effects of an occlusive zinc medicated dressing on the bacterial flora in excised wounds in the rat.	the effects of three different dressings - two occlusive and one non-occlusive - on the bacterial flora of excised wounds in rats were studied. the number of colony forming units per gram of granulation tissue were significantly lower 4, 8 and 12 days postoperatively in wounds treated with a zinc medicated occlusive dressing compared with wounds treated with non-zinc medicated occlusive hydrocolloid dressing or wet-to-dry non-occlusive gauze dressing. the minimum inhibitory concentration (mic) o ...	1989	2714861
proteeae groin skin carriage among nursing home residents--resistance to antiseptics.	proteeae carriage was evaluated in groin skin carriers following vigorous antiseptic application. three proteus mirabilis carriers were treated with 60% isopropyl alcohol or 4% chlorhexidine, observed to prevent skin contact, and then recultured; at four and eight hours p mirabilis numbers remained undiminished. ten proteeae carriers received a series of nine body baths with soap, chlorhexidine, and 0.75% povidone-iodine plus three cefazolin injections over 16 to 34 days; cumulative treatments f ...	1989	2715627
[enzymes of the phosphogluconate pathway in amebas].	glucose-6-phosphate and 6-phosphogluconate dehydrogenases (g6pd and 6pgd) are revealed in amoeba proteus by electrophoresis in polyacrylamide gels, thus proving the availability of the phosphogluconic pathway in amoebae. 6pgd is marked as a single band, and g6pd shows multiple banding. when an amoebic homogenate is obtained using triton-100, a supplementary form of g6pd extracted from membranes of some cell organelles (presumably mitochondria) becomes apparent. hexose-6-phosphate dehydrogenase s ...	1989	2718261
[experience in the use of anti-colibacillus and proteus lactoglobulin as a supplement to milk products in diet therapy at a specialized childrens' collective].	a new biologically active supplement (bas) for infant food was tested at an infant's home. bas-ig contains lactoglobulin, an immune preparation against colibacillus and proteus. during the primary examination of the infants in the infant's home intestinal dysbacteriosis was revealed in 100% of the infants, clinical signs of dysbacteriosis were detected in 88.4% of the infants. two successive courses of feeding the infants with products enriched with the new supplement resulted in a significant i ...	1989	2718415
positive weil-felix reactions in a case of rickettsialpox.		1989	2722341
expanding the phenotype of the proteus syndrome: a severely affected patient with new findings.	here we report on a boy who died at 16 1/2 months with hemihypertrophy, eye abnormalities, macrodactyly, hamartomas, pigmented nevi, cerebral involvement, and other anomalies compatible with the proteus syndrome. in addition, he also had abnormalities previously unreported in the proteus syndrome including craniosynostosis and complex congenital heart defects. he seems to represent an extremely severe form of the proteus syndrome and expands the already broad range of the phenotype.	1989	2729359
aztreonam in the treatment of gram-negative meningitis and other gram-negative infections.	ninety patients (41 males, 49 females) with a diagnosis of meningitis, urinary tract infection (uti), gastroenteritis or other miscellaneous gram-negative infections were enrolled. their ages ranged from 7 days to 10 years, with a mean age of 4 months. 58 (63%) patients had an etiology confirmed by either positive culture (52; 89%) or latex agglutination (6; 10%). 41 of these patients had meningitis diagnosed by positive cse culture (38) or by positive csf latex agglutination (3); 27/41 patients ...	1989	2731448
in-vitro interactions of fce 22101 with aminoglycosides against gram-negative rods.	agar dilution mics of fce 22101 were measured for 894 consecutively-isolated gram-negative rods from clinical specimens (413 escherichia coli, 104 klebsiella spp., 54 enterobacter spp., 19 citrobacter spp., 131 proteus spp., 43 acinetobacter spp., 9 serratia spp., 3 providencia spp., 4 yersinia spp., 3 hafnia spp. and 111 pseudomonas spp.). excluding pseudomonas spp., 98% of these isolates were susceptible to 8 mg/l fce 22101. resistance (mic greater than 8 mg/l) varied from 11% in serratia spp. ...	1989	2732132
root canal microflora: qualitative changes after endodontic instrumentation.	the changes in the pattern of bacteria in root canal after repeated washing with naocl and endodontic instrumentation were evaluated. samples were obtained from the root canals of patients before and after endodontic instrumentation, and analyzed according to the usual microbiological techniques. washing with naocl and endodontic instrumentation act against bacteria such as peptostreptococci, streptococcus sanguis, actinomyces israelii, proteus mirabilis, bacteroides, whereas streptococcus lacti ...	1989	2732777
[intraspecific polymorphism of glucose-6-phosphate dehydrogenase in amoeba proteus].	seven amoeba proteus strains of different origin were studied using a polyacrylamide gel electrophoresis micromethod in the presence of nadp+ in cathode buffer. the strains examined differ in glucose-6-phosphate dehydrogenase (g6pd) zymograms: the majority of them (a, l, f, da and bk) display 3 bands, whereas strains b and c show 4 and 2 bands, respectively. all but strain c have a common band of high relative mobility. strain b shows two fast migrating bands instead of a single band typical of ...	1989	2734853
topical treatment of burns using aserbine.	a cream containing malic, benzoic and salicylic acid esters (aserbine) was evaluated as a topical dressing for dermal burns. children with thermal injuries covering less than 20 per cent of the body surface area (bsa) were treated with aserbine (53 patients), daromide (31 patients) or silver sulphadiazine (ssd) (16 patients). in these groups, hot liquids were the cause of injury in 92 per cent, 100 per cent and 80 per cent of patients respectively. there were no significant differences in the nu ...	1989	2736050
observations on sudanese camel nasal myiasis caused by the larvae of cephalopina titillator.	forty-four camels slaughtered at nyala abattoir, western sudan, were examined for infection with the larvae of cephalopina titillator. the infection rate was found to be 100 p. 100. the parasitic burden ranged between 8-243 per animal. they were recovered throughout the year. the first stage larvae were noticed from december to may, indicating the breeding season of the fly. the larvae were found to cause visible pathological lesions on the nasopharynx. these were also demonstrated histopatholog ...	1989	2740563
[today's prognosis of urolithiasis caused by infection calculi in the young child].	in 24 infants (age 1-4 years) with urolithiasis a good and recurrence-free long-term prognosis is shown in 15 patients with infected stones under following conditions: early diagnosis and operative treatment without residual stones, immediate therapy of bacteriuria and close-meshed follow-up controls. in these 15 infants the morbidity peak was in the second year of life. however in the remaining 9 infants with calcium oxalate calculi recurrent stones did occur on an average of 6 years despite of ...	1989	2741562
[the etiology of suppurative-inflammatory diseases caused by opportunistic microorganisms at the noninfectious disease clinic].	5,853 strains of opportunistic microorganisms have been isolated from hospitalized patients at a polyclinic. the following microorganisms have been found to cause purulent inflammatory diseases most frequently: escherichia coli (21.6%), staphylococcus epidermidis (15.93%), staphylococcus aureus (14.54%), microorganisms of the genus klebsiella (11.86%), pseudomonas aeruginosa (7.91%) and microorganisms of the genus proteus (7.5%). in cases of mixed infections gram-negative bacteria prevail. the a ...	1989	2741604
rufloxacin (mf-934): in vitro and in vivo antibacterial activity.	rufloxacin (mf-934) is a new quinolone which shows in vitro antibacterial activity against e. coli, salmonella, klebsiella, proteus and staphylococcus spp. lower in vitro activity was observed with pseudomonas, serratia, enterobacter and the streptococci group d. the antimicrobial activity of mf-934 in vitro is higher than that of nalidixic acid but lower than that of ciprofloxacin, ofloxacin, pefloxacin or norfloxacin. the protective effects of mf-934 in systemic infections in mice are lower th ...	1989	2743869
clinical evaluation of imipenem/cilastatin in the therapy of severe infections in high-risk patients.	a clinical trial was carried out to evaluate the effectiveness of treatment with imipenem/cilastatin in life-threatening infections in high-risk patients. thirty hospitalized patients (22 men and 8 women), aged 28 to 78 years, with impaired host defences and severe infections were treated with imipenem/cilastatin at a dosage ranging between 1 and 3 g daily i.v. at 8 or 12 h intervals. the average length of therapy was 8.61 +/- 3.14 days. the isolated organisms were as follows: escherichia coli [ ...	1989	2743870
[proteus syndrome. a contribution to the further differential diagnosis of congenital local gigantism].	four sporadically occurring characteristic cases of the proteus syndrome are described. all patients show the main features of the disease, consisting of hemihypertrophy, partial gigantism of hands and/or feet with soft-tissue hypertrophy, plane naevi, subcutaneous tumours, and cranial anomalies. there is a remarkable polymorphism of the symptoms. anamnestic, clinical and paraclinical findings are shown in tables. based on a survey of the literature, the main aspects of genetics and of different ...	1989	2745142
the problem of bacterial resistance to antibiotics among strains isolated from hospital patients in lagos and ibadan, nigeria.	bacterial infections are still an important cause of illness and death in developing countries, where the widespread and indiscriminate use of antibiotics has led to serious problems of resistance to the older, less expensive agents. the results of routine sensitivity testing of clinical isolates from patients in lagos and ibadan, nigeria show a high prevalence of strains resistant to penicillin, tetracycline, ampicillin, co-trimoxazole and chloramphenicol, with between 70% and 90% of strains of ...	1989	2745266
[antimicrobial activity of cefteram comparison with other oral antibiotics].	antimicrobacterial activities of cefteram (cftm) against clinical isolates collected in 1988 were compared with those of new beta-lactams. 1. antibacterial activities of cftm against streptococcus pneumoniae, streptococcus pyogenes, haemophilus influenzae, branhamella catarrhalis isolated from acute respiratory tract infections were 8- to 16-fold higher than those of cefaclor (ccl). 2. activities of cefixime (cfix) were superior to those of cftm against b. catarrhalis, escherichia coli, klebsiel ...	1989	2746861
transcervical uterine cultures with a new endometrial suction curette: a comparison of three sampling methods in postpartum endometritis.	the potential for cervicovaginal contamination has precluded direct sampling of the endometrial cavity and has led to the development of multi-lumen protected catheter systems, among other techniques. the extent of this presumed contamination was examined using three different techniques in 55 postpartum women with the diagnosis of endometritis. each woman had the endometrium sampled with an unprotected cotton-tipped swab, a double-lumen catheter with brush, and a flexible endometrial suction cu ...	1989	2748066
comparative in vitro susceptibilities of 504 bacteremic isolates to ticarcillin plus clavulanic acid and other antimicrobial agents.	a total of 504 clinical bacteremic isolates were tested for susceptibility to ticarcillin-clavulanic acid and 12 other antibiotics. ticarcillin-clavulanic acid showed superior antibacterial activity compared to penicillin, mezlocillin, piperacillin, ticarcillin, gentamicin, and amikacin against bacteremic isolates of methicillin-susceptible staphylococcus aureus and staphylococcus epidermidis. however, ticarcillin-clavulanic acid's activity was inferior to that of vancomycin against methicillin- ...	1989	2752713
microbiological characterization of dactimicin: antibacterial activity towards gram-positive and gram-negative bacteria.	dactimicin is the first aminoglycoside antibiotic of dactylosporangium origin, consisting of a pseudo-disaccharide and an amino acid. it has also a formimidoyl moiety instead of the deoxystreptamine found in other aminoglycosides. the authors considered the antibacterial activity of dactimicin compared with amikacin, gentamicin and the fortimicins against gram-positive and gram-negative bacteria. dactimicin showed remarkable antibacterial activity against all strains tested: in particular the mi ...	1989	2752910
[experience and evaluation of studies on the prevalence of nosocomial infections at a general hospital].	from november 1986 to december 1987 we undertook 5 different counts of the prevalence of nosocomial infections (ni) in 4,572 patients (100% of the population). the following are the most important average values: ni overall, 14.4%, distributed as follows: urinary infections, 29.1%; surgical wounds, 21.6%; pneumonias 8.6%; phlebitis due to catheter insertion, 14.5%; and bacteremias, 5.2%. the most commonly found microorganisms were e. coli, s. aureus, proteus mirabilis and enterococcus. these stu ...	1989	2756209
mortality of harbor seal pups at different sites in the inland waters of washington.	we examined the mortality rates and causes of death of harbor seal (phoca vitulina) pups in three regions of the inland waters of washington (usa) in 1984. one hundred eight pups were collected during 239 searches of the shoreline areas near harbor seal haulout sites or through public reports. minimum neonatal (up to 1 mo after birth) mortality rates at these regions ranged from 12% to 26% of the pups born. neonatal mortality was highest in the strait of juan de fuca; 33 of the estimated 105 (31 ...	1989	2761005
modern presentations of bezold's abscess.	the use of antibiotics in suppurative otitis media has greatly diminished the incidence of complications. deep neck abscess arising from acute mastoiditis, a disease thoroughly described by frederick bezold early in this century, has become rare. in the last three years we have treated five cases of deep neck abscess of otogenic origin at our hospital. these cases exemplify bezold's classic description in their site of origin in the mastoid process and route of spread in the neck. however, our c ...	1989	2765234
mechanics and control of the cytoskeleton in amoeba proteus.	many models of the cytoskeletal motility of amoeba proteus can be formulated in terms of the theory of reactive interpenetrating flow (dembo and harlow, 1986). we have devised numerical methodology for testing such models against the phenomenon of steady axisymmetric fountain flow. the simplest workable scheme revealed by such tests (the minimal model) is the main preoccupation of this study. all parameters of the minimal model are determined from available data. using these parameters the model ...	1989	2765645
vesicoureteric reflux and urinary calculi in children.	we present 5 patients with urinary calculi and vesicoureteric reflux (vur). in 4 patients the vur was probably primary and in 1 it was secondary to the calculus disease. the incidence of calculi with reflux is approximately 0.5% whereas the incidence of reflux with calculi is approximately 8%.	1989	2765758
[urinary tract infection in children: clinical analysis and investigation].	the urinary tract is a common site for bacterial infection in childhood. the most important aspect of urinary tract infection in childhood is that it can lead to severe and progressive renal disease. from march 1983 to march 1987, 63 cases of suspected urinary tract infection were collected in taichung vgh. among them only 24 cases reached our diagnostic criteria. eight cases were within 2 years old, which all are male. sixteen cases were beyond 2 years old, which the ratio of male to female is ...	1989	2766067
t-mod pathway, a reduced sequence for identification of gram-negative urinary tract pathogens.	in this paper, we describe a reduced sequence of identification that includes t-mod medium, a selective and differential isolation medium which allows accurate presumptive identification of the most common gram-negative bacteria encountered in urine samples. the present study, performed on bacteria isolated from 1,762 independent urine samples, has shown that a few selected tests (lysine and ornithine decarboxylase, urease and trehalose fermentation tests) improve the identification accuracy of ...	1989	2768451
[effects of sulbactam on the activity of cefoperazone against various clinical isolates].	sulbactam/cefoperazone (sbt/cpz) have been used in clinical infusion at ratios of 1:1 and 1:2 in japan and u.s.a., respectively. after an administration of these drugs as a 1:1 parenteral formulation, the ratio of levels of cpz and sbt in blood was 1:1/4 to 1:1/5 for 1 to 2 hours, whereas the ratio of free, unbound drug levels was 1:1.4 to 1:1.5. in urine these drugs were excreted at a ratio between 1:1 and 1:4 during 6 hours after the infusion. antimicrobial interaction studies using various co ...	1989	2769941
[chronic pyelonephritis in polycystic kidney].	the characteristics of chronic pyelonephritis are studied in 37 patients out of a total of 53 patients with proved renal polycystosis. a group of 71 patients with chronic pyelonephritis selected at random are used as a control group. the frequency of chronic pyelonephritis among the patients with renal polycystosis is 69.8%. the difference between the mean age of the patients with renal polycystosis and chronic pyelonephritis and the patients with renal polycystosis without chronic pyelonephriti ...	1989	2773465
[circulation of intestinal infection in the families of patients with rheumatic diseases and the state of humoral immunity to enterobacterial antigens].	elisa quantitation of antibodies to klebsiella pneumonia, proteus mirabilis, and yersinia enterocolitica was conducted in 75 ankylosing spondylitis (as), rheumatoid arthritis (ra), and systemic lupus erythematosus (sle) probands and in 262 of their first-degree relatives. the control group comprised 28 healthy donors. sixteen (64 per cent) as probands (12 with b27+) and 26 (30.2 per cent) their relatives (14 with b27+) were found to have high titres of antibodies to klebsiella pneumonia. in 18 ( ...	1989	2773562
antimicrobial activity of julifloricine isolated from prosopis juliflora.	antimicrobial activity of julifloricine, an alkaloid isolated from prosopis juliflora, was studied in vitro against 40 microorganisms which included 31 bacteria, two candida species, five dermatophytic fungi and two viruses. significant inhibitory effect was noted against gram positive bacteria. the minimal inhibitory concentration (mic) for staphylococcus aureus, s. epidermidis, s. citreus, streptococcus pyogenes and sarcina lutea was 1 microgram/ml and against s. faecalis, s. pneumoniae, s. la ...	1989	2775330
lipopolysaccharides of proteus penneri species novum.	the lipopolysaccharides (lps), obtained from twenty strains of proteus penneri, were shown to contain 3-deoxy-d-manno-2-octulosonic acid (kdo), l-glycero-d-manno- and d-glycero-d-manno-heptoses, glucose, 2-amino-2-deoxyglucose, 2-amino-2-deoxygalactose, and galacturonic acid. galactose was lacking in three lps and, in some lps, glucuronic acid, rhamnose, lysine, and two unknown constituents were detected. chemotypes of the p. penneri are discussed.	1989	2776126
occurrence of drug-resistant bacteria in communal well water around port harcourt, nigeria.	a total of 108 raw water samples was collected from 36 wells at nine shanty settlements around port harcourt, nigeria, over a period of 7 months. samples were analysed for their bacteriological quality. selected bacterial strains isolated from the samples were tested for their susceptibility to ten commonly used antibiotics. the organisms isolated include pseudomonas spp., klebsiella spp., staphylococcus spp., proteus spp., enterococcus faecalis, aeromonas spp., escherichia coli, chromobacterium ...	1989	2776852
purification, composition, and activity of two bactenecins, antibacterial peptides of bovine neutrophils.	extracts of granules of bovine neutrophils are known to exhibit a marked antibacterial activity in vitro. by a simple, two-step chromatographic procedure, we have resolved two peptide components of the antibacterial system. they were named bac-5 and bac-7 from the general term bactenecin and had molecular masses of about 5 and 7 kilodaltons, respectively. over 45 and 20% of the amino acid residues in the two bactenecins are proline and arginine, respectively. the remaining amino acids are mainly ...	1989	2777377
optimization of a medium for the rapid urease test for detection of campylobacter pylori in gastric antral biopsies.	we developed a buffered azide-free urea medium which is sensitive, specific, and nontoxic for rapid detection of campylobacter pylori in gastric biopsies. detection of urease produced by the organism provides the basis for the test. the substrate is urea in monobasic sodium phosphate buffer, and phenol red provides indication of the ph change that results from urease activity. a rapid change from yellow to red occurs in the presence of c. pylori, even at low concentrations of the organism. a slo ...	1989	2778071
blockage of urinary catheters: role of microorganisms and constituents of the urine on formation of encrustations.	long-term indwelling urinary catheters may become blocked in some patients by formation of encrustations made up of aggregated struvite crystals while other patients rarely develop blocked catheters. we have designated these groups as "blockers", "intermediates" or "non-blockers". to further understand this phenomenon we followed 32 catheterized elderly women in a nursing home. catheters were changed six times at 2 week intervals. patients tended to remain as "blockers", "intermediates" or "non- ...	1989	2778465
purification of cross-reacting protein antigen shared by yersinia enterocolitica and other gram-negative bacteria with monoclonal antibody.	a monoclonal antibody against the yersinia enterocolitica 60-kilodalton (kda) antigen, designated cross-reacting protein antigen (crpa), was obtained by cell fusion. the crpa common to gram-negative bacteria was purified from y. enterocolitica by the affinity chromatography with the monoclonal antibody (igg1) thus obtained. the purified crpa showed a single band of 60 kda in sds-polyacrylamide gel electrophoresis (sds-page), and reacted with rabbit antisera against y. enterocolitica, vibrio chol ...	1989	2779474
proteeae groin skin carriage in ambulatory geriatric outpatients.	aerobic gram-negative bacillus (agnb) groin skin carriage was prospectively studied in ambulatory geriatric outpatients: 42 from three nursing homes and 44 from private homes. initially, 12 (28.6%) proteeae carriers were in the former group and 3 (6.8%) were in the latter (p = 0.01). at one year, 6 of 7 surviving nursing home carriers remained proteeae carriers while none from private homes remained carriers (p = 0.007). the annual prevalence of proteeae carriage was 14 (33.3%) in nursing homes ...	1989	2785550
in vitro and in vivo antibacterial activity of the new semisynthetic cephalosporin cefpirome.	cefpirome (hr 810), a new semisynthetic cephalosporin derivative, was found to have a broad antibacterial spectrum against gram-positive and gram-negative bacteria. against staphylococcus aureus, cefpirome was more active than not only cefotaxime and ceftazidime but also cefotiam. against gram-negative bacteria, especially, enterobacter cloacae and citrobacter freundii, it was also more active than the other antibiotics tested, but against pseudomonas aeruginosa, it was less active than ceftazid ...	1989	2785801
induction potency of various beta-lactam derivatives in gram-negative rods.	the induction potency of various beta-lactams as well as that of 'nonspecific' inducers such as the media employed or body fluids were studied in gram-negative clinical isolates and in their resistant corresponding counterparts. in all wild-type isolates quite a few beta-lactams (mainly cefoxitin and imipenem) shared the ability to induce the chromosomal beta-lactamase, whereas all beta-lactams - including 6-aps and 7-cps clavulanic acid, and sulbactam (both beta-lactamase inhibitors), exhibited ...	1989	2785904
in vitro and in vivo evaluations of a new broad-spectrum oral cephalosporin, bmy-28232, and its prodrug esters.	the in vitro activity of a new cephalosporin, bmy-28232 (7-[(z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3-[ (z)-1- propenyl]-3-cephem-4-carboxylic acid), was compared with those of cefuroxime and bmy-28488, the 3-vinyl congener of bmy-28232, against 899 bacteria including strains resistant to newer cephalosporins. bmy-28232 displayed potent, broad-spectrum antibacterial activity with high stability to various types of beta-lactamase. its acetoxyethyl ester (bmy-28271) and pivaloyloxymet ...	1989	2786371
interactions of fce 22101 with class i beta-lactamases.	hyperproduction of chromosomal class i beta-lactamase causes resistance to newer cephalosporins in enterobacter cloacae, citrobacter freundii, serratia spp. and indole-positive proteeae. we examined the interactions of fce 22101 with these enzymes, measuring (i) antibiotic lability to pure enzyme, (ii) inducing power and (iii) activity against beta-lactamase-inducible strains and their -depressed and -basal mutants. turnover numbers of fce 22101 were between 0.7 and 1.5 molecules hydrolysed/min/ ...	1989	2786519
in-vitro activity of fce 22101 and synergy studies with other antimicrobial agents.	fce 22101 is a penem antibiotic with broad in-vitro activity similar to that of imipenem, although less active against pseudomonas aeruginosa. combinations of fce 22101 with ciprofloxacin or gentamicin against methicillin-resistant staphylococcus aureus and methicillin-resistant staph. epidermidis resulted in addition or indifference by the chequerboard method. the combination of fce 22101 and gentamicin against streptococcus faecalis was usually additive. against enterobacter cloacae fce 22101 ...	1989	2786520
in vitro activity and beta-lactamase stability of a new carbapenem, sm-7338.	sm-7338, a new carbapenem, inhibited most members of the family enterobacteriaceae at mics of 0.015 to 0.25 microgram/ml, including klebsiella oxytoca, citrobacter freundii, enterobacter cloacae, and proteus vulgaris isolates resistant to cefotaxime, ceftazidime, piperacillin, and gentamicin. it was two- to eightfold more active than imipenem, but it inhibited pseudomonas aeruginosa at 1 to 8 micrograms/ml, which was comparable to the activity of imipenem. haemophilus, neisseria, and branhamella ...	1989	2789493
lomefloxacin activity against 2,813 clinical isolates: a collaborative study at three medical centers in brazil.	the in vitro activity of lomefloxacin was compared to norfloxacin and two parenteral drugs against 2,813 clinical isolates at three medical centers in brazil. considering mics less than or equal to 4 micrograms/ml as the criterion, lomefloxacin inhibited 97.9% of all enterobacteriaceae, 100% of staphylococci, 100% of neisseria gonorrhoeae, 100% of campylobacter pylori, 81% of pseudomonas aeruginosa, and 79% of streptococcus spp. norfloxacin was generally comparable in potency and spectrum, but c ...	1989	2791496