Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| high prevalence of plasmid-mediated quinolone resistance determinants in escherichia coli and klebsiella pneumoniae isolates from pediatric patients in china. | in this study, the prevalence of the plasmid-mediated quinolone resistance (pmqr) genes among pediatric clinical isolates of escherichia coli and klebsiella pneumoniae was investigated. a total of 243 nonduplicate clinical isolates of e. coli and k. pneumoniae collected between january 2010 and december 2012 from beijing, china, were studied. in total, 55 isolates (22.63%) were positive for pmqr genes, the most frequently detected gene was qnrs (13.2%), followed by aac(6')-ib-cr (6.2%) and qnrb ... | 2017 | 27167505 |
| persisting transmission of carbapenemase-producing klebsiella pneumoniae due to an environmental reservoir in a university hospital, france, 2012 to 2014. | in france, the proportion of episodes of carbapenemase-producing enterobacteriaceae (cpe) with no recent stay or hospitalisation abroad is increasing. in this study, we investigate epidemiological links between apparently unrelated cases of oxa-48-producing klebsiella pneumoniae (kp oxa-48) colonisation or infection. we genotyped detected organisms by repetitive sequence-based pcr, and used a dynamic registry of cases and contacts to cross-reference patients' hospital stays. between 1 november 2 ... | 2016 | 27168586 |
| in vitro and in vivo efficacy, toxicity, bio-distribution and resistance selection of a novel antibacterial drug candidate. | a synthetic antimicrobial peptide was identified as a possible candidate for the development of a new antibacterial drug. the peptide, set-m33l, showed a mic90 below 1.5 μm and 3 μm for pseudomonas aeruginosa and klebsiella pneumoniae, respectively. in in vivo models of p. aeruginosa infections, the peptide and its pegylated form (set-m33l-peg) enabled a survival percentage of 60-80% in sepsis and lung infections when injected twice i.v. at 5 mg/kg, and completely healed skin infections when adm ... | 2016 | 27169671 |
| molecular characterization of class b carbapenemases in advanced stage of dissemination and emergence of class d carbapenemases in enterobacteriaceae from croatia. | carbapenemases involved in acquired carbapenem resistance in enterobacteriaceae belong to ambler class a serin β-lactamases, class b metallo-β-lactamases (mbl) or class d oxa-48-like β-lactamases. the aim of the present study was to analyse the molecular epidemiology and the mechanisms and routes of spread of class b and class d carbapenemases in croatia. in total 68 isolates were analyzed. antibiotic susceptibility was determined by broth microdilution method. pcr was used to detect antibiotic- ... | 2016 | 27174090 |
| [susceptibilities of multidrug-resistant pathogens responsible for complicated skin and soft tissue infections to standard bacteriophage cocktails]. | skin and soft tissue infections (sstis) may represent a wide clinical spectrum from cellulitis to high-mortality associated necrotizing fasciitis. limitations in therapy due to the multiple drug resistance, leads to increase in the morbidity and mortality rates, especially in complicated sstis such as diabetic foot, decubitus, and surgical wound infections. therefore, alternative treatment strategies other than antibiotics are needed in appropriate clinical conditions. "bacteriophage therapy", w ... | 2016 | 27175494 |
| antibacterial activity of miswak salvadora persica extracts against isolated and genetically identified oral cavity pathogens. | despite medical progress worldwide, dental caries are still widespread. miswak is derived from the plant arak (salvadora persica). it is used by muslim peoples as a natural product for the cleansing of teeth, to ensure oral and dental hygiene. | 2016 | 27177110 |
| impact of blandm-1 on fitness and pathogenicity of escherichia coli and klebsiella pneumoniae. | the objective of this study was to determine whether acquisition of new delhi metallo-β-lactamase-1 (ndm-1) has an impact on the fitness and virulence of escherichia coli and klebsiella pneumoniae. growth kinetics and the cost of fitness of ndm-1 plasmid carriage were assessed in isogenic e. coli j53 and k. pneumoniae prz in vitro by pairwise competition assays. the pathogenicity of ndm-1-expressing e. coli and k. pneumoniae strains and their isogenic controls was analysed in vivo using a galler ... | 2016 | 27179815 |
| antiradical and antimicrobial activity of phenolic fractions obtained from honeys. | honey is a natural product consisting of multiple components which determine its dietary and medicinal properties. in this work there were studied methanol fractions obtained from seven honeys from lower silesia (poland) collected in different seasons of three successive years. melissopalynologic studies revealed that two of them were polyfloral, and five were classified as monofloral (two buckwheat and three rapes). the amount of phenolic compounds in honeys varied from 0.09 to 0.38 mg per g of ... | 2016 | 27180430 |
| a single-center, six-year evaluation of the role of pulsed-field gel electrophoresis in suspected burn center outbreaks. | pulsed-field gel electrophoresis (pfge) has been used as an adjunct to traditional hospital epidemiology in numerous outbreak investigations, including in burn centers. however, its most effective real-world application remains unclear, with few longitudinal descriptions of use. | 2016 | 27180602 |
| eco-friendly drugs from the marine environment: spongeweed-synthesized silver nanoparticles are highly effective on plasmodium falciparum and its vector anopheles stephensi, with little non-target effects on predatory copepods. | mosquitoes act as vectors of devastating pathogens and parasites, representing a key threat for millions of humans and animals worldwide. the control of mosquito-borne diseases is facing a number of crucial challenges, including the emergence of artemisinin and chloroquine resistance in plasmodium parasites, as well as the presence of mosquito vectors resistant to synthetic and microbial pesticides. therefore, eco-friendly tools are urgently required. here, a synergic approach relying to nanotec ... | 2016 | 27180838 |
| structural determination of the polysaccharide isolated from biofilms produced by a clinical strain of klebsiella pneumoniae. | klebsiella pneumoniae are gram negative opportunistic pathogens producing capsular (k) polysaccharides. seventy-seven different k antigens have been described and they are the basis for k serotyping. capsular polysaccharides are important virulence factors and have a relevant role for the structure of biofilm communities. nevertheless, little information is available on the polysaccharides produced in biofilm matrices by klebsiella spp. in the present study, a clinical isolate of klebsiella pneu ... | 2016 | 27182661 |
| characterization of the genetic environment of the blakpc-2 gene among klebsiella pneumoniae isolates from a chinese hospital. | infection caused by carbapenem-resistant klebsiella pneumoniae has become a major healthcare threat and kpc-2 enzyme is a dominant factor mediating carbapenems resistance in k. pneumoniae. this study was designed to determine the genetic environment of blakpc-2, which prevailed in clinical k. pneumoniae isolates recovered in huashan hospital, shanghai, china. forty-two clinical isolates were included in this study by blakpc-2 screening. after multilocus sequence typing and plasmid analyses of pc ... | 2017 | 27183358 |
| [molecular-genetic analysis of microorganisms with intraepithelial invasion isolated from patients with colorectal cancer]. | the facultative aerobic bacteria isolated from the mucosa of rectum in patients with colorectal cancer in the zone of malignant tumor and neighboring normal mucosa was studied using molecular-genetic methods. the species attribution of bacteria was implemented using the cultural-morphological analysis and sequencing of the 16s rrna locus. the microorganisms with the intraepithelial invasion to rectal mucosa isolated were identified as representatives of the adherent-invasive (aiec) subgroup of e ... | 2016 | 27183716 |
| groel/es inhibitors as potential antibiotics. | we recently reported results from a high-throughput screening effort that identified 235 inhibitors of the escherichia coli groel/es chaperonin system [bioorg. med. chem. lett.2014, 24, 786]. as the groel/es chaperonin system is essential for growth under all conditions, we reasoned that targeting groel/es with small molecule inhibitors could be a viable antibacterial strategy. extending from our initial screen, we report here the antibacterial activities of 22 groel/es inhibitors against a pane ... | 2016 | 27184767 |
| a case of lobar pneumonia and sepsis with death caused by invasive klebsiella rhinoscleromatis infection. | klebsiella pneumoniae often causes pneumonia and other infections in heavy drinkers and patients with diabetes. pneumonia caused by klebsiella rhinoscleromatis, a subspecies of k. pneumoniae, has not been previously reported. we report a case of pneumonia caused by k. rhinoscleromatis. a 68-year-old man with type 2 diabetes visited our department complaining fever and fatigue for 10 days and cough and bloody sputum for two days. his japan coma scale score was i-1, body temperature 38.3 °c, blood ... | 2016 | 27184935 |
| increased biofilm formation ability in klebsiella pneumoniae after short-term exposure to a simulated microgravity environment. | biofilm formation is closely related to the pathogenetic processes of klebsiella pneumoniae, which frequently causes infections in immunocompromised individuals. the immune system of astronauts is compromised in spaceflight. accordingly, k. pneumoniae, which used to be isolated from orbiting spacecraft and astronauts, poses potential threats to the health of astronauts and mission security. microgravity is a key environmental cue during spaceflight. therefore, determining its effects on bacteria ... | 2016 | 27185296 |
| investigation of bacterial inactivation in apheresis platelets with 24 or 30 hours between inoculation and inactivation. | blood centre logistics, staffing and donor scheduling may be optimized if pathogen inactivation (pi) of platelets can be delayed until day 1, but bacteria may rapidly grow during this time. this study evaluates bacterial pi performed 24 and 30 h after collection. | 2016 | 27185478 |
| ndm-4- and ndm-5-producing klebsiella pneumoniae coinfection in a 6-month-old infant. | 2016 | 27185797 | |
| in vitro emergence of high persistence upon periodic aminoglycoside challenge in the eskape pathogens. | health care-associated infections present a major threat to modern medical care. six worrisome nosocomial pathogens-enterococcus faecium, staphylococcus aureus, klebsiella pneumoniae, acinetobacter baumannii, pseudomonas aeruginosa, and enterobacter spp.-are collectively referred to as the "eskape bugs." they are notorious for extensive multidrug resistance, yet persistence, or the phenotypic tolerance displayed by a variant subpopulation, remains underappreciated in these pathogens. importantly ... | 2016 | 27185802 |
| thiolactomycin-based inhibitors of bacterial β-ketoacyl-acp synthases with in vivo activity. | β-ketoacyl-acp synthases (kas) are key enzymes involved in the type ii bacterial fatty acid biosynthesis (fasii) pathway and are putative targets for antibacterial discovery. several natural product kas inhibitors have previously been reported, including thiolactomycin (tlm), which is produced by nocardia spp. here we describe the synthesis and characterization of optically pure 5r-thiolactomycin (tlm) analogues that show improved whole cell activity against bacterial strains including methicill ... | 2016 | 27187871 |
| diabetes mellitus has no significant influence on the prevalence of antenatal asymptomatic bacteriuria. | diabetes is a known risk factor for asymptomatic bacteriuria (asb). however, the influence of diabetes on antenatal asb was previously not addressed. | 2016 | 27190802 |
| antibiotic adjuvant therapy for multi-drug resistant carbapenemases producing klebsiella pneumoniae associated sepsis: a case study. | rising resistance and spread of k. pneumoniae strains, create great concerns in treating sepsis patients due to high incidence of mortality and morbidity. the current study is a case of a 20-year-old male with sepsis and bilateral lung lesions infected with multi-drug resistant (mdr) carbapenemase producing k. pneumoniae (kpc) showing resistance to carbapenem and polymyxin. based on sensitivity report, patient was put on antibiotic adjuvant: elores (ceftriaxone, sulbactam, disodium edetate) alon ... | 2016 | 27190808 |
| characterization of esbl- and ampc-producing and fluoroquinolone-resistant enterobacteriaceae isolated from mouflons (ovis orientalis musimon) in austria and germany. | the aim of this study was to investigate the presence of β-lactamase producing or fluoroquinolone-resistant members of the family enterobacteriaceae in european mouflons (ovis orientalis musimon). the mouflon samples originated from nasal and perineal swabs and/or organ samples in cases of a suspected infection. only one of the 32 mouflons was tested positive for the presence of enterobacteriaceae that displayed either an esbl/ampc phenotype or were resistant to ciprofloxacin. the positively tes ... | 2016 | 27192164 |
| over expression of adeabc and acrab-tolc efflux systems confers tigecycline resistance in clinical isolates of acinetobacter baumannii and klebsiella pneumoniae. | due to the wide use of tigecycline in the treatment of severe infections caused by multidrug-resistant (mdr) bacteria, clinical resistance to tigecycline has increased in recent years. here, we investigated the relationship between tigecycline resistance and the expression of efflux pumps. | 2016 | 27192584 |
| secular trends in klebsiella pneumoniae isolated in a tertiary-care hospital: increasing prevalence and accelerated decline in antimicrobial susceptibility. | introduction klebsiella pneumoniae has become an increasingly important etiologic agent of nosocomial infections in recent years. this is mainly due to the expression of virulence factors and development of resistance to several antimicrobial drugs. methods this retrospective study examines data obtained from the microbiology laboratory of a brazilian tertiary-care hospital. to assess temporal trends in prevalence and antimicrobial susceptibility, k. pneumoniae isolates were analyzed from 2000 t ... | 2016 | 27192586 |
| association of diverse bacterial communities in human bile samples with biliary tract disorders: a survey using culture and polymerase chain reaction-denaturing gradient gel electrophoresis methods. | bacterial infection is considered a predisposing factor for disorders of the biliary tract. this study aimed to determine the diversity of bacterial communities in bile samples and their involvement in the occurrence of biliary tract diseases. a total of 102 bile samples were collected during endoscopic retrograde cholangiopancreatography (ercp). characterization of bacteria was done using culture and polymerase chain reaction-denaturing gradient gel electrophoresis (pcr-dgge) methods. antimicro ... | 2016 | 27193890 |
| preliminary survey of local bacteriophages with lytic activity against multi-drug resistant bacteria. | bacteriophages (phages) represent a potential alternative for combating multi-drug resistant bacteria. because of their narrow host range and the ever emergence of novel pathogen variants the continued search for phages is a prerequisite for optimal treatment of bacterial infections. here we performed an ad hoc survey in the surroundings of a university hospital for the presence of phages with therapeutic potential. to this end, 16 aquatic samples of different origins and locations were tested s ... | 2016 | 27194637 |
| bloodstream-to-eye infections are facilitated by outer blood-retinal barrier dysfunction. | the blood-retinal barrier (brb) functions to maintain the immune privilege of the eye, which is necessary for normal vision. the outer brb is formed by tightly-associated retinal pigment epithelial (rpe) cells which limit transport within the retinal environment, maintaining retinal function and viability. retinal microvascular complications and rpe dysfunction resulting from diabetes and diabetic retinopathy cause permeability changes in the brb that compromise barrier function. diabetes is the ... | 2016 | 27195776 |
| scalable and environmentally benign process for smart textile nanofinishing. | a major challenge in nanotechnology is that of determining how to introduce green and sustainable principles when assembling individual nanoscale elements to create working devices. for instance, textile nanofinishing is restricted by the many constraints of traditional pad-dry-cure processes, such as the use of costly chemical precursors to produce nanoparticles (nps), the high liquid and energy consumption, the production of harmful liquid wastes, and multistep batch operations. by integrating ... | 2016 | 27196424 |
| [antibibiotic resistance by nosocomial infections' causal agents]. | the antibibiotic resistance by nosocomial infections (ni) causal agents constitutes a seriously global problematic that involves the mexican institute of social security's regional general hospital 1 in chihuahua, mexico; although with special features that required to be specified and evaluated, in order to concrete an effective therapy. | 2016 | 27197104 |
| genetic antimicrobial susceptibility testing in gram-negative sepsis - impact on time to results in a routine laboratory. | diagnostic testing of positive blood cultures is among the most critical tasks performed by clinical microbiology laboratories, and the total analysis time from sampling to results should be kept as short as possible. by providing identification of pelleted bacteria directly from positive blood-cultures, maldi-tof ms opens for relatively low-complex species-adjusted genetic susceptibility testing from the same bacterial pellet. in our lab routine, we prospectively evaluated a rapid in-house real ... | 2016 | 27197792 |
| draft genome sequence of a multidrug-resistant klebsiella pneumoniae strain isolated from king abdullah medical city, makkah, saudi arabia. | multidrug-resistant (mdr) gram-negative infections represent a growing problem and a serious global threat. carbapenem-resistant klebsiella pneumoniae is perhaps cause the most difficult infection to treat and is associated with increased morbidity and mortality. here, we report the draft genome sequence of an mdr k. pneumoniae strain isolated from makkah, saudi arabia. | 2016 | 27198017 |
| beyond susceptible and resistant, part iii: treatment of infections due to gram-negative organisms producing carbapenemases. | carbapenemases are enzymes that are capable of inactivating all or almost all beta-lactam antimicrobial agents. these enzymes are frequently coexpressed with other resistance mechanisms to non-beta-lactams, leading to extremely drug-resistant pathogens. once a curiosity, these enzymes have spread into organisms that are among the most common causes of infection, such as klebsiella pneumoniae and escherichia coli. identification of these organisms has proved challenging for clinical microbiology ... | 2017 | 27199618 |
| molecular epidemiology of carbapenem-resistant klebsiella pneumoniae in greece. | hospital infections caused by carbapenem-resistant klebsiella pneumoniae (crkp) constitute a worldwide problem associated with high rates of treatment failure and mortality. in greece, crkp have emerged in 2002 due to vim carbapenemase production and later due to kpc, ndm and oxa-48-like carbapenemases that have become endemic. the molecular epidemiology of crkp strains is dynamic, as antibiotic consumption and worldwide traveling are strongly associated with global spread of crkp isolates. late ... | 2016 | 27206024 |
| predictors of mortality in korean patients with pyogenic liver abscess: a single center, retrospective study. | the mortality rate of pyogenic liver abscess (pla) has decreased dramatically, but it remains a potentially life threatening disease. most cases are cryptogenic or occur in elderly men with underlying biliary tract disease. although several studies have addressed the characteristics and etiology of pla, research on factors affecting pla-associated mortality is lacking. this study intended to identify the clinical and radiological features, pathogens, complications, and predictors of mortality in ... | 2016 | 27206434 |
| [septic shock in pyogenic liver abscess: clinical considerations]. | pyogenic liver abscess (pla) is a life-threatening condition, despite advances in diagnostic technology and strategies for treatment. a strong predictor of mortality in this condition is septic shock. this study describes clinical, biochemical, and radiologic features in patients with pla with or without septic shock, with the intent of describing risk factors for septic shock. | 2016 | 27206435 |
| the continuing plague of extended-spectrum β-lactamase-producing enterobacteriaceae infections. | antimicrobial resistance is a common iatrogenic complication of modern life and medical care. one of the most demonstrative examples is the exponential increase in the incidence of extended-spectrum β-lactamases (esbls) production among enterobacteriaceae, which is the most common human pathogens outside of the hospital settings. infections resulting from esbl-producing bacteria are associated with devastating outcomes, now affecting even previously healthy individuals. this development poses an ... | 2016 | 27208763 |
| multidrug-resistant bacteria in the community: trends and lessons learned. | multidrug resistant (mdr) bacteria are one of the most important threats to public health. typically, mdr bacteria are associated with nosocomial infections. however, some mdr bacteria have become prevalent causes of community-acquired infections. the spread of mdr bacteria into the community is a crucial development, and is associated with increased morbidity, mortality, health care costs, and antibiotic use. factors associated with community dissemination of mdr bacteria overlap but are distin ... | 2016 | 27208764 |
| [pathogens and clinical characteristics of bacterial infection in hematology department between 2010 and 2014]. | to analyze the characteristics of distribution and drug resistance of bacterial infection in several different parts of hematology department inpatients of anhui provincial hospital from january 2010 to december 2014, including patients who had received hematopoietic stem cell transplantation (hsct). | 2016 | 27210872 |
| modeling meropenem treatment, alone and in combination with daptomycin, for kpc-producing klebsiella pneumoniae strains with unusually low carbapenem mics. | klebsiella pneumoniae strains producing k. pneumoniae carbapenemase (kpc) cause serious infections in debilitated and immunocompromised patients and are associated with prolonged hospital stays and increased mortality rates. daptomycin is a lipopeptide used against staphylococcus aureus infection and considered inactive against gram-negative bacteria. we investigated the effectiveness of a daptomycin-meropenem combination by synergy kill curve and a pharmacokinetic/pharmacodynamic model. the com ... | 2016 | 27216067 |
| frequency of bkc-1-producing klebsiella species isolates. | bkc-1 is a new class a serine carbapenemase that was recently identified in klebsiella pneumoniae clinical isolates. the principal objective of this study was to evaluate the frequency of blabkc-1 by testing a collection of klebsiella isolates. only 2 of 635 klebsiella isolates (0.3%) carried blabkc-1 the two bkc-1-producing isolates belonged to clonal complex 442 and possessed identical pulsed-field gel electrophoresis patterns. the blabkc-1 gene was inserted into a 10-kb plasmid that was ident ... | 2016 | 27216068 |
| in vivo pharmacodynamic target assessment of delafloxacin against staphylococcus aureus, streptococcus pneumoniae, and klebsiella pneumoniae in a murine lung infection model. | delafloxacin is a broad-spectrum anionic fluoroquinolone under development for the treatment of bacterial pneumonia. the goal of the study was to determine the pharmacokinetic/pharmacodynamic (pk/pd) targets in the murine lung infection model for staphylococcus aureus, streptococcus pneumoniae, and klebsiella pneumoniae four isolates of each species were utilized for in vivo studies: for s. aureus, one methicillin-susceptible and three methicillin-resistant isolates; s. pneumoniae, two penicilli ... | 2016 | 27216072 |
| changes in the frequencies of β-lactamase genes among enterobacteriaceae isolates in u.s. hospitals, 2012 to 2014: activity of ceftazidime-avibactam tested against β-lactamase-producing isolates. | among 15,588 enterobacteriaceae isolates collected in 63 u.s. hospitals from 2012 to 2014, 2,129 (13.7%) displayed an extended-spectrum β-lactamase (esbl) phenotype. these rates were similar over time (13.2 to 13.9%); however, differences among escherichia coli (12.7 and 15.1% in 2012 and 2014; p = 0.007) and klebsiella pneumoniae (18.9 and 15.5% in 2012 and 2014; p = 0.006) were noted when comparing 2014 and 2012. carbapenem-resistant enterobacteriaceae (cre) (2.3 and 1.8%) and carbapenem-resis ... | 2016 | 27216075 |
| antimicrobial susceptibility among european gram-negative and gram-positive isolates collected as part of the tigecycline evaluation and surveillance trial (2004-2014). | european centers (n = 226) involved in the tigecycline evaluation and surveillance trial (test, 2004-2014) submitted data and bacterial isolates. | 2017 | 27216271 |
| tigecycline susceptibility and molecular resistance mechanisms among clinical klebsiella pneumoniae strains isolated during non-tigecycline treatment. | tigecycline is one of the few therapeutic options that are available for treating serious clinical infections. however, tigecycline nonsusceptible enterobacteriaceae has emerged recently in china. in this study, a total of 28 clinical klebsiella pneumoniae isolates that were not previously exposed to tigecycline were collected and confirmed for tigecycline minimum inhibitory concentrations (mics) using standard broth microdilution tests. to elucidate the mechanisms underlying molecular resistanc ... | 2017 | 27219271 |
| the postantibiotic effect and post-β-lactamase-inhibitor effect of ceftazidime, ceftaroline and aztreonam in combination with avibactam against target gram-negative bacteria. | the magnitudes of the postantibiotic effect (pae) and post-β-lactamase-inhibitory effect (plie) of ceftazidime-avibactam, ceftaroline-avibactam, and aztreonam-avibactam were determined against isolates of enterobacteriaceae and pseudomonas aeruginosa that either harboured genes encoding serine and/or metallo-β-lactamases, or did not harbour bla genes. the bla genes included ones that encoded extended spectrum β-lactamases, ampc and kpc β-lactamases, and one metallo-β-lactamase, ndm-1. no substan ... | 2016 | 27221329 |
| prevalence and antibacterial resistance patterns of extended-spectrum beta-lactamase producing gram-negative bacteria isolated from ocular infections. | extended-spectrum beta-lactamases (esbls) mediated resistance is more prevalent worldwide, especially among gram-negative bacterial isolates, conferring resistance to the expanded spectrum cephalosporins. as limited data were available on the prevalence of esbls in this area, the current study was undertaken to determine the prevalence, antibacterial resistance patterns, and molecular detection and characterization of esbl encoding resistance genes among ocular gram-negative bacterial isolates f ... | 2016 | 27221683 |
| [investigation of antimicrobial resistance of klebsiella pneumoniae and pseudomonas aeruginosa isolates from rat-like animals around a hospital in guangzhou]. | to investigate antimicrobial resistance of klebsiella pneumoniae and pseudomonas aeruginosa isolates in fecal samples from rat-like animals. | 2016 | 27222186 |
| extended spectrum beta-lactamase producing enterobacteriaceae causing bloodstream infections in rural ghana, 2007-2012. | high prevalence of extended spectrum beta-lactamase (esbl) producing enterobacteriaceae threatens treatment options for invasive bloodstream infections in sub-saharan africa. | 2016 | 27222489 |
| prevalence of extended-spectrum beta-lactamase-producing klebsiella pneumoniae isolates in nosocomial and community-acquired urinary tract infections. | klebsiella pneumoniae is a family member of enterobacteriaceae. isolates of k. pneumoniae produce enzymes that cause decomposition of third generation cephalosporins. these enzymes are known as extended-spectrum beta-lactamase (esbl). resistance of k. pneumoniae to beta-lactamase antibiotics is commonly mediated by beta-lactamase genes. | 2016 | 27226874 |
| unusual indolent course of a chronic active epstein-barr virus-associated natural killer cell lymphoproliferative disorder. | natural killer (nk) cell lymphoproliferative disorders are uncommon and the epstein-barr virus (ebv) plays an important aetiological role in their pathogenesis. we report a 20-year-old male with a chronic active ebv infection associated with a nk cell lymphoproliferative disorder which had an unusual indolent course. he presented to the sultan qaboos university hospital in muscat, oman, in december 2011 with a history of intermittent fever and coughing. examinations revealed generalised lymphade ... | 2016 | 27226916 |
| recommended initial antimicrobial therapy for emphysematous pyelonephritis: 51 cases and 14-year-experience of a tertiary referral center. | the aim of this study was to investigate the profiles of pathogens and patterns of antibiotic resistance of emphysematous pyelonephritis (epn), offering recommendations for initial antibiotic treatment.between january, 2001, and november, 2014, demographic data, presenting clinical features, management strategies, and treatment outcomes of 51 patients with epn were retrospectively reviewed, analyzing microbiological characteristics of causative pathogens and patterns of antibiotic resistance.ove ... | 2016 | 27227920 |
| effect of drying on the bioactive compounds, antioxidant, antibacterial and antityrosinase activities of pomegranate peel. | the use of pomegranate peel is highly associated with its rich phenolic concentration. series of drying methods are recommended since bioactive compounds are highly sensitive to thermal degradation. the study was conducted to evaluate the effects of drying on the bioactive compounds, antioxidant as well as antibacterial and antityrosinase activities of pomegranate peel. | 2016 | 27229852 |
| high production of 3-hydroxypropionic acid in klebsiella pneumoniae by systematic optimization of glycerol metabolism. | 3-hydroxypropionic acid (3-hp) is an important platform chemical proposed by the united states department of energy. 3-hp can be converted to a series of bulk chemicals. biological production of 3-hp has made great progress in recent years. however, low yield of 3-hp restricts its commercialization. in this study, systematic optimization was conducted towards high-yield production of 3-hp in klebsiella pneumoniae. we first investigated appropriate promoters for the key enzyme (aldehyde dehydroge ... | 2016 | 27230116 |
| label-free gram-negative bacteria detection using bacteriophage-adhesin-coated long-period gratings. | this paper presents a novel application of a highly sensitive sensor based on long-period gratings (lpgs) coated with t4 bacteriophage adhesin for gram-negative bacteria detection. we show here, that the sensor evidently recognizes escherichia coli k-12 (pcm2560), whereas in the reference tests - elisa and biacore - the results are questionable. for lpgs sensor the resonant wavelength shift observed for e. coli k-12 was approximately half of that measured for e.coli b (positive control). the bia ... | 2016 | 27231592 |
| pathogen prevalence and antimicrobial susceptibility among enterobacteriaceae causing hospital-associated intra-abdominal infections in adults in the united states (2012-2013). | selection and prompt initiation of the appropriate empiric antimicrobial therapy are critical to decrease morbidity and mortality and shorten the length of hospitalization among patients with hospital-associated intra-abdominal infections (ha-iais). therapeutic choices for the treatment of patients with ha-iai require careful consideration. this study was conducted to evaluate the antimicrobial susceptibility of common pathogens collected from adult patients with ha-iai in the united states. | 2016 | 27234360 |
| multicentre investigation of carbapenemase-producing escherichia coli and klebsiella pneumoniae in german hospitals. | aim of this study was to determine the incidence and molecular epidemiology of carbapenemase-producing escherichia coli and klebsiella pneumoniae in germany. e. coli and k. pneumoniae isolates from clinical samples which were non-susceptible to carbapenems were collected in laboratories serving 20 hospitals throughout germany from november 2013 to april 2014. the isolates were tested for the presence of carbapenemases by pcr and phenotypic methods and typed by multilocus sequence typing. risk fa ... | 2016 | 27237423 |
| galleria mellonella as a model system to assess the efficacy of antimicrobial agents against klebsiella pneumoniae infection. | 2016 | 27237961 | |
| pathways regulating the pbgp operon and colistin resistance in klebsiella pneumoniae strains. | in this study, we investigated colistin resistance mechanisms associated with the regulation of the pbgp operon in klebsiella pneumoniae, using four isogenic pairs of colistin-susceptible strains and their colistin-resistant derivatives and two colistin-resistant clinical isolates. amino acid sequence alterations of phopq, pmrab, and mgrb were investigated, and mrna expression levels of phoq, pmrb, pmrd, and pbgp were measured using quantitative real-time pcr. the phoq and pmrb genes were delete ... | 2016 | 27238937 |
| ertapenem in outpatient parenteral antimicrobial therapy for complicated urinary tract infections. | ertapenem is a broad-spectrum antibiotic that is increasingly being utilized. its dosing convenience renders it suitable for outpatient therapy, and its pharmacokinetic characteristics favour its use against complicated urinary tract infections (cutis). despite this, sufficient clinical data are lacking for its use against cutis in the outpatient setting. we assessed the microbiological and clinical cure rates associated with ertapenem treatment for cutis in two outpatient parenteral antimicrobi ... | 2017 | 27239695 |
| rapid identification of klebsiella pneumoniae by matrix-assisted laser desorption/ionization-time of flight mass spectrometry and detection of meropenem resistance by flow cytometric assay. | the aim of this study was to develop a rapid detection method of carbapenem-resistant klebsiella pneumoniae (crkp) strains both maldi-tof ms and flow cytometry (fcm). | 2016 | 27239799 |
| n-terminal ile-orn- and trp-orn-motif repeats enhance membrane interaction and increase the antimicrobial activity of apidaecins against pseudomonas aeruginosa. | the gram-negative bacterium pseudomonas aeruginosa is a life-threatening nosocomial pathogen due to its generally low susceptibility toward antibiotics. furthermore, many strains have acquired resistance mechanisms requiring new antimicrobials with novel mechanisms to enhance treatment options. proline-rich antimicrobial peptides, such as the apidaecin analog api137, are highly efficient against various enterobacteriaceae infections in mice, but less active against p. aeruginosa in vitro. here, ... | 2016 | 27243004 |
| a case of liver abscess caused by tigecycline-nonsusceptible klebsiella pneumoniae. | 2016 | 27247260 | |
| molecular dissection of blakpc-2-bearing plasmids evolving in klebsiella pneumoniae isolated at one teaching hospital in shanghai, china. | the presence of carbapenemase gene blakpc-2 in a wide variety of plasmids, especially conjugative plasmids, is key to the rapid, worldwide spread of carbapenemase enzymes. thirty-eight, non-duplicated, carbapenem-resistant, clinical klebsiella pneumoniae isolates were collected, all carrying blakpc-2-bearing plasmids. relaxase analysis was used to classify these plasmids; 8 and 30 plasmids belonged to the mobp3 and mobf12 subfamilies, respectively. phylogenetic analysis revealed two genetic subc ... | 2016 | 27252157 |
| structural and functional characterization of aerobactin synthetase iuca from a hypervirulent pathotype of klebsiella pneumoniae. | iron is a vital mineral nutrient required by virtually all life forms to prosper; pathogenic bacteria are no exception. despite the abundance of iron within the human host, highly regulated iron physiology can result in exceedingly low levels of iron bioavailable to prospective invading bacteria. to combat this scarcity of iron, many pathogenic bacteria have acquired specific and efficient iron acquisition systems, which allow them to thrive in iron-deficient host environments. one of the more p ... | 2016 | 27253399 |
| a combined disc method with resazurin agar plate assay for early phenotypic screening of kpc, mbl and oxa-48 carbapenemases among enterobacteriaceae. | to validate a combined disc method along with resazurin chromogenic agar for early screening and differentiation of klebsiella pneumoniae carbapenemase, metallo-β-lactamase and oxa-48 carbapenemase-producing enterobacteriaceae. | 2016 | 27253907 |
| defects in early cell recruitment contribute to the increased susceptibility to respiratory klebsiella pneumoniae infection in diabetic mice. | diabetes is associated with increased susceptibility to klebsiella pneumoniae and poor prognosis with infection. we demonstrate accelerated mortality in mice with streptozotocin-induced diabetes following tracheal instillation of k. pneumoniae. diabetic mice recruited fewer granulocytes to the alveolar airspace and had reduced early production of cxcl1, cxcl2, il-1β and tnf-α following tracheal instillation of k. pneumoniae-lipopolysaccharide. additionally, tlr2 and tirap expression following k. ... | 2016 | 27256462 |
| comparative activity of ciprofloxacin, levofloxacin and moxifloxacin against klebsiella pneumoniae, pseudomonas aeruginosa and stenotrophomonas maltophilia assessed by minimum inhibitory concentrations and time-kill studies. | the aim of this study was to compare the in vitro susceptibility of klebsiella pneumoniae, pseudomonas aeruginosa and stenotrophomonas maltophilia to three fluoroquinolones. the minimum inhibitory concentrations (mics) to ciprofloxacin, levofloxacin and moxifloxacin were examined by e-test® for a total of 40 k. pneumoniae strains, 40 s. maltophilia strains and 40 p. aeruginosa strains. then, the bactericidal activity of these fluoroquinolones was investigated on five strains of each bacterial sp ... | 2016 | 27257956 |
| rapid detection of antibiotic resistance in gram-negative bacteria through assessment of changes in cellular morphology. | rapid antimicrobial susceptibility testing has the potential to improve patient outcomes and reduce healthcare-associated costs. in this study, a novel assay based on bacterial cell elongation after exposure to an antibiotic (ceftazidime) was evaluated for its ability to rapidly detect resistance in gram-negative bacteria. the assay was used to detect resistance in a large collection of strains containing 320 clinical isolates of acinetobacter baumannii, 171 clinical isolates of klebsiella pneum ... | 2017 | 27259183 |
| genetic environment of the kpc gene in acinetobacter baumannii st2 clone from puerto rico and genomic insights into its drug resistance. | carbapenems are considered the last-resort antibiotics to treat infections caused by multidrug-resistant gram-negative bacilli. the klebsiella pneumoniae carbapenemase (kpc) enzyme hydrolyses β-lactam antibiotics including the carbapenems. kpc has been detected worldwide in enterobacteriaceae and pseudomonas aeruginosa isolates associated with transposon tn4401 commonly located in plasmids. acinetobacter baumannii has become an important multidrug-resistant nosocomial pathogen. kpc-producing a. ... | 2016 | 27259867 |
| klebsiella pneumoniae primary liver abscess associated with ruxolitinib. | 2016 | 27259987 | |
| outcomes of spontaneous bacterial peritonitis in liver transplant recipients with allograft failure. | spontaneous bacterial peritonitis (sbp) carries appreciable morbidity and mortality in the pre-liver transplant (lt) setting. however, the occurrence of sbp and its consequences in the post-lt setting have not been well characterized. | 2016 | 27261101 |
| glutathione-s-transferase fosa6 of klebsiella pneumoniae origin conferring fosfomycin resistance in esbl-producing escherichia coli. | the objectives of this study were to elucidate the genetic context of a novel plasmid-mediated fosa variant, fosa6, conferring fosfomycin resistance and to characterize the kinetic properties of fosa6. | 2016 | 27261267 |
| mass gathering medicine (hajj pilgrimage in saudi arabia): the clinical pattern of pneumonia among pilgrims during hajj. | the planned annual hajj to the holy shrines in makkah, saudi arabia, is recognized as one of the largest recurring religious mass gatherings globally, and the outbreak of infectious diseases is of major concern. we aim to study the incidence, etiology, risk factors, length of hospital stay, and mortality rate of pneumonia amongst pilgrims admitted to al-ansar general hospital, madinah, saudi arabia during the hajj period of december 2004-november 2013. a retrospective analysis of all patients di ... | 2016 | 27262693 |
| evaluation of selected oral cavity microbiota--risk factors of management complications in patients with masticatory system disorders. | the retrospective analysis of data on oral cavity clinical status in relation to microbiota species composition is presented. the research regards patients of different age, with and without congenital malformation, pretreatment assessed for occurrence of pathological changes in the masticatory system. samples of the swabs collected from each patient (from dental plaque, periodontium and dental pockets) were used for identification of oral protozoans in wet slides and stained preparations; addit ... | 2016 | 27262961 |
| modification and evaluation of the carba np test by use of paper strip for simple and rapid detection of carbapenemase-producing enterobacteriaceae. | carbapenemase-producing enterobacteriaceae (cpe) isolates have now emerged worldwide. we therefore modified the phenotypic carba np test by use of a filter paper strip for easily and rapidly identifying cpe in routine laboratory. a collection of 56 cpe and carbapenemase-producing pseudomonas spp. isolates (including 28 ndm-1, 11 imp-14a, 1 imp-1, 1 imp-4, 1 imp-9, 1 imp-15, 4 vim-2, 1 vim-1, 1 imp-14a with vim-2, 3 oxa-48, 3 oxa-181 and 1 kpc-2 producers) and 41 non-cpe isolates (including 19 es ... | 2016 | 27263012 |
| evaluation of pulmonary microsporidiosis in iatrogenically immunosuppressed patients. | microsporidia spp. are ubiquitous and infect a wide variety of intervertebrates and vertebrates, including humans. pulmonary microsporidiosis, characterized by nonspecific symptoms like fever, cough and dyspnea, is often overlooked in the differential diagnosis of pulmonary infections in immunsupressed patients. in this study, we aimed to determine the prevalence of pulmonary microsporidiosis in iatrogenically immunosuppressed patients and to evaluate the patient characteristics. | 2016 | 27266280 |
| [the activity of moxalactam against enterobacteriaceae and anaerobia in vitro]. | to observe the antibacterial activity of moxalactam against enterobacteriaceae bacteria and anaerobic bacteria in vitro, and to compare with other antibacterial drugs, for providing experimental basis for the clinical application of moxalactam. | 2016 | 27266357 |
| antibacterial activities of the methanol extracts, fractions and compounds from harungana madagascariensis lam. ex poir. (hypericaceae). | harungana madagascariensis lam. ex poir. (hypericaceae) is used in folk medicine to treat a variety of human ailments, mainly antibacterial, antifungal, antiviral and viral infections. in the present study, the methanol extract from the leaves (hml) and bark (hmb) of this plant as well as fractions (hmba-c), sub-fractions (hmba1-5) and compounds isolated from hmba and hmbb namely betulinic acid (1), madagascin (2), ferruginin a (3) and kaempferol-3-o-β-d-glucopyranoside (4) were tested for their ... | 2016 | 27267830 |
| bacteremia due to eskape pathogens: an emerging problem in cancer patients. | in recent years, a few of the antibiotic-resistant bacteria, known as eskape pathogens, have been found responsible for serious infections. we investigated the risk factors, and impact of eskape pathogens on course of blood stream infections (bsis) in cancer patients in comparison to coagulase negative staphylococci (cons). | 2016 | 27268592 |
| detection of colistin resistance gene mcr-1 in hypervirulent klebsiella pneumoniae and escherichia coli isolates from an infant with diarrhea in china. | 2016 | 27270278 | |
| horizontal transfer of carbapenemase-encoding plasmids and comparison with hospital epidemiology data. | carbapenemase-producing organisms have spread worldwide, and infections with these bacteria cause significant morbidity. horizontal transfer of plasmids carrying genes that encode carbapenemases plays an important role in the spread of multidrug-resistant gram-negative bacteria. here we investigate parameters regulating conjugation using an escherichia coli laboratory strain that lacks plasmids or restriction enzyme modification systems as a recipient and also using patient isolates as donors an ... | 2016 | 27270289 |
| clinical predictors and microbiology of ventilator-associated pneumonia in the intensive care unit: a retrospective analysis in six italian hospitals. | the purpose of this study was to assess the main clinical predictors and microbiological features of ventilator-associated pneumonia (vap) in the intensive care unit (icu) environment. this work is a retrospective analysis over one year from september 2010 to september 2011. patients' risk factors, causes of admission, comorbidities and respiratory specimens collected in six italian icus were reviewed. incidence and case fatality rate of vap were evaluated. after stratification for vap developme ... | 2016 | 27272120 |
| [characteristics of urinary tract infection in kidney transplant recipients and non-recipient patients]. | to compare the characteristics of urinary tract infection (uti) between kidney transplant recipients and non-recipient patients. | 2016 | 27273995 |
| mechanisms of antimicrobial resistance in eskape pathogens. | the eskape pathogens (enterococcus faecium, staphylococcus aureus, klebsiella pneumoniae, acinetobacter baumannii, pseudomonas aeruginosa, and enterobacter species) are the leading cause of nosocomial infections throughout the world. most of them are multidrug resistant isolates, which is one of the greatest challenges in clinical practice. multidrug resistance is amongst the top three threats to global public health and is usually caused by excessive drug usage or prescription, inappropriate us ... | 2016 | 27274985 |
| pharmacodynamics and differential activity of nitrofurantoin against esbl-positive pathogens involved in urinary tract infections. | although nitrofurantoin has been used for >60 years for the treatment of uncomplicated urinary tract infections, its pharmacodynamic properties are not fully explored. use is increasing because of increasing resistance to other antimicrobials due to esbls. | 2016 | 27278898 |
| a new report of nocardiopsis valliformis strain ot1 from alkaline lonar crater of india and its use in synthesis of silver nanoparticles with special reference to evaluation of antibacterial activity and cytotoxicity. | the authors report the biological synthesis of silver nanoparticles (agnps) by alkaliphilic actinobacterium nocardiopsis valliformis ot1 strain isolated for the first time from lonar crater, india. the primary detection of silver nps formation was made by colour change from colourless to dark brown and confirmed by uv-vis spectrum of agnps at 423 nm, specific for agnps. further, agnps were characterized by nanoparticle tracking analysis, zeta sizer, fourier transform infrared spectroscopy (ftir) ... | 2016 | 27278909 |
| colonization of multidrug resistant pathogens in a hybrid pediatric cardiac surgery center. | the incidence of multidrug resistant microorganisms worldwide is increasing. the aim of the study was to present institutional experience with the multidrug resistant microorganism colonization patterns observed in children with congenital heart diseases hospitalized in a hybrid pediatric cardiac surgery center. | 2016 | 27279859 |
| purification and characterization of ethyl 2-methyl-3-oxobutanoate reductase from klebsiella pneumoniae if03319. | an enzyme that catalyzes a reduction of ethyl 2-methyl-3-oxobutanoate (1) to ethyl (2r,3s) 3-hydroxy- 2-methylbutanoate was found in klebsiella pneumoniae ifo 3319 cells. the enzyme was isolated from the cells and purified 250-fold by ammonium sulfate fractionation, ion exchange chromatography, affinity chromatography, and gel filtration. the purified enzyme was found to be a monomer protein with a molecular weight of approximately 31,000 and an isoelectric point of 6.2. it was nadph-dependent a ... | 1996 | 27281138 |
| first evidence of polar flagella in klebsiella pneumoniae isolated from a patient with neonatal sepsis. | the genus klebsiella belongs to the family enterobacteriaceae, and is currently considered to be non-motile and non-flagellated. in the present work, 25 klebsiella strains isolated from nosocomial infections were assessed for motility under different growth conditions. one klebsiella isolate, kpbuap021, demonstrated a swim-like motility phenotype. the k. pneumoniae genotype was confirmed by 16s rrna and rpob gene sequence analysis. multilocus sequence typing analysis also revealed that the kpbua ... | 2016 | 27283194 |
| molecular evolution of a klebsiella pneumoniae st278 isolate harboring blandm-7 and involved in nosocomial transmission. | during 2013, st278 klebsiella pneumoniae with blandm-7 was isolated from the urine (kpn01) and rectum (kpn02) of a patient in calgary, canada. the same strain (kpn04) was subsequently isolated from another patient in the same unit. interestingly, a carbapenem-susceptible k. pneumoniae st278 (kpn06) was obtained 1 month later from the blood of the second patient. next-generation sequencing (ngs) revealed that the loss of carbapenem-resistance in kpn06 was due to a 5-kb deletion on the blandm-7-ha ... | 2016 | 27284091 |
| isolation of kpc 3-producing enterobacter aerogenes in a patient colonized by mdr klebsiella pneumoniae. | we describe the interspecies transmission of the plasmid-mediated blakpc-3 gene, which confers carbapenem resistance, between clinically relevant gram-negative bacteria in a single patient. a kpc-3 producing enterobacter aerogenes was isolated from a hospitalized patient previously colonized and then infected by a klebsiella pneumoniae st101 carrying the blakpc-3 gene. the strains showed identical plasmids. since intense horizontal exchanges among bacteria can occur in the gut, clinicians should ... | 2016 | 27284988 |
| clostridium difficile ribotype 033 colitis in a patient following broad-spectrum antibiotic treatment for kpcproducing klebsiella pneumoniae infection, italy. | this report describes a case of clostridium difficile ribotype 033 colitis in a patient treated with multiple antibiotics for kpc-producing klebsiella pneumoniae pancreatitis. diagnostic, clinical and therapeutic features are discussed. to the best of our knowledge, this is the first case of c. difficile ribotype 033 clinical infection reported from italy. | 2016 | 27284989 |
| insect-derived short proline-rich and murine cathelicidin-related antimicrobial peptides act synergistically on gram-negative bacteria in vitro. | organisms express a set of antimicrobial peptides (amp) to protect the host against invading microbes by targeting their membranes or intracellular structures. structurally optimized proline-rich amps (pramps) are substantially more efficient in murine infection models than previously assumed from in vitro activities. thus, we hypothesized that pramps act synergistically with lytic amps intrinsically produced in hosts in response to an infection. | 2016 | 27285299 |
| the effect of sub-inhibitory concentrations of rifaximin on urease production and on other virulence factors expressed by klebsiella pneumoniae, proteus mirabilis, pseudomonas aeruginosa and staphylococcus aureus. | rifaximin, a topical derivative of rifampin, inhibited urease production and other virulence factors at sub-mic concentrations in strains involved in hepatic encephalopathy and the expression of methicillin resistance in staphylococcus aureus. in particular, urease production was affected in all proteus mirabilis and klebsiella pneumoniae strains as well as in all tested pseudomonas aeruginosa isolates. other exotoxins, synthesized by p. aeruginosa, such as protease, gelatinase, lipase, lecithin ... | 2017 | 27285830 |
| performance of a pcr assay for the rapid identification of the klebsiella pneumoniae st258 epidemic clone in latin american clinical isolates. | the worldwide dissemination of klebsiella pneumoniae carbapenemase (kpc)-producing klebsiella pneumoniae st258 demands a rapid pcr-based typing method to detect unique genes of the st258 clone. this study evaluates a pcr developed by adler et al. (2014) for the detection of st258 in k. pneumoniae clinical isolates centered on the identification of the pilv-i and prp genes. we tested 143 clinical isolates from argentina (n=109), chile (n=1), colombia (n=1), costa rica (n=2), ecuador (n=5), el sal ... | 2016 | 27287559 |
| nosocomial infections and resistance pattern of common bacterial isolates in an intensive care unit of a tertiary hospital in nigeria: a 4-year review. | infection is a major determinant of clinical outcome among patients in the intensive care unit. however, these data are lacking in most developing countries; hence, we set out to describe the profile of nosocomial infection in one of the major tertiary hospitals in northern nigeria. | 2016 | 27288622 |
| whole-genome comparative analysis of two carbapenem-resistant st-258 klebsiella pneumoniae strains isolated during a north-eastern ohio outbreak: differences within the high heterogeneity zones. | klebsiella pneumoniae has become one of the most dangerous causative agents of hospital infections due to the acquisition of resistance to carbapenems, one of the last resort families of antibiotics. resistance is usually mediated by carbapenemases coded for by different classes of genes. a prolonged outbreak of carbapenem-resistant k. pneumoniae infections has been recently described in northeastern ohio. most strains isolated from patients during this outbreak belong to mlst sequence type 258 ... | 2016 | 27289094 |
| characterization of antimicrobial resistance in klebsiella species isolated from chicken broilers. | the prevalence of antimicrobial resistant klebsiella pneumoniae in poultry products has been a public concern, as it severely endangers food safety and human health. in this study, we investigated 90 antimicrobial resistant klebsiella strains that were isolated from a commercial broiler slaughter plant in shandong province of china. nearly all (89/90) of the isolates were identified as infectious phylogenetic group kpi-type k. pneumoniae. out of these 90 strains, 87 (96.7%) were multidrug-resist ... | 2016 | 27289192 |
| kefiran-alginate gel microspheres for oral delivery of ciprofloxacin. | ciprofloxacin is a broad-spectrum antibiotic associated with gastric and intestinal side effects after extended oral administration. alginate is a biopolymer commonly employed in gel synthesis by ionotropic gelation, but unstable in the presence of biological metal-chelating compounds and/or under dried conditions. kefiran is a microbial biopolymer able to form gels with the advantage of displaying antimicrobial activity. in the present study, kefiran-alginate gel microspheres were developed to ... | 2016 | 27289312 |