Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| liver cirrhosis and diabetes mellitus are risk factors for staphylococcus aureus infection in patients with healthcare-associated or hospital-acquired pneumonia. | the risk factors for staphylococcus aureus (s. aureus) pneumonia are not fully identified. the aim of this work was to find out the clinical characteristics associated with s. aureus infection in patients with healthcare-associated pneumonia (hcap) and hospital-acquired pneumonia (hap), which may be applicable for more appropriate selection of empiric antibiotic therapy. | 2016 | 26998356 |
| clinical significance of community- and healthcare-acquired carbapenem-resistant enterobacteriaceae isolates. | this study was conducted to investigate the clinical significance, manifestations, microbiological characteristics and outcomes of carbapenem-resistant enterobacteriaceae (cre) isolates, and compare the clinical features of community- and healthcare-acquired cre isolates. a total of 78 patients were identified to have cre. klebsiella pneumoniae was the most common pathogens (n = 42, 53.8%), followed by enterobacter cloacae (n = 24, 30.8%), and escherichia coli (n = 11, 14.1%). most of the patien ... | 2016 | 26999356 |
| epidemiology and virulence of klebsiella pneumoniae. | strains of klebsiella pneumoniae are frequently opportunistic pathogens implicated in urinary tract and catheter-associated urinary-tract infections of hospitalized patients and compromised individuals. infections are particularly difficult to treat since most clinical isolates exhibit resistance to several antibiotics leading to treatment failure and the possibility of systemic dissemination. infections of medical devices such as urinary catheters is a major site of k. pneumoniae infections and ... | 2016 | 26999397 |
| [the application of selective chromogenic agar for detecting enterobacteria with production of beta-lactamases]. | the detection of enterobacteria with production of beta-lactamases of extended spectrum in selective chromogenic agar was analyzed the results ofdetection of beta-lactamases of extended spectrum was compared with "double disc" technique. the smears from mucous membrane of guttur and rectum from patients were analyzed in parallel on solid growth agar (endo or mac conkey) and on selective agar chromagartm esbl (chromagar france). the production of beta-lactamases of extended spectrum was confirmed ... | 2015 | 26999867 |
| probable interspecies transfer of the bla(vim-4) gene between enterobacter cloacae and klebsiella pneumoniae in a single infant patient. | we report the interspecies transfer of the bla(vlm-4) gene in mbl-producing enterobacter cloacae and klebsiella pneumoniae isolates from a newborn patient who had received meropenem therapy. we show evidence that gene bla(vim-4) was transmitted as a part of the class-1 integron on a ca. -90 kb conjugative plasmid. high homology of nucleotide sequence was observed between the integron found in vim-4 producing e. cloacae and k. pneumoniae strains tested and class-1 integrons previously reporteded ... | 2015 | 26999960 |
| resistance trends among clinical isolates in china reported from chinet surveillance of bacterial resistance, 2005-2014. | with the aim of gathering temporal trends on bacterial epidemiology and resistance from multiple laboratories in china, the chinet surveillance system was organized in 2005. antimicrobial susceptibility testing was carried out according to a unified protocol using the kirby-bauer method or automated systems. results were analyzed according to clinical and laboratory standards institute (clsi) 2014 definitions. between 2005 and 2014, the number of bacterial isolates ranged between 22,774 and 84,5 ... | 2016 | 27000156 |
| pharmacokinetics-pharmacodynamics of a novel β-lactamase inhibitor, cb-618, in combination with meropenem in an in vitro infection model. | the usefulness of β-lactam antimicrobial agents is threatened as never before by β-lactamase-producing bacteria. for this reason, there has been renewed interest in the development of broad-spectrum β-lactamase inhibitors. herein we describe the results of dose fractionation and dose-ranging studies carried out using a one-compartment in vitro infection model to determine the exposure measure for cb-618, a novel β-lactamase inhibitor, most predictive of the efficacy when given in combination wit ... | 2016 | 27001820 |
| new variant of an imipenemase, imp-32, in klebsiella pneumoniae from a fatal case of a thai patient. | 2016 | 27002735 | |
| risk factors for kpc-producing klebsiella pneumoniae: watch out for surgery. | this study describes the molecular characteristics and risk factors associated with carbapenem-resistant klebsiella pneumoniae strains. risk factors associated with kpc-producing k. pneumoniae strains were investigated in this case-control study from may 2011 to may 2013. bacterial identification was performed by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (maldi-tof ms). antimicrobial susceptibility was determined by broth microdilution. carbapenemase production ... | 2016 | 27002853 |
| epidemiology of hospital-acquired pneumonia: results of a central european multicenter, prospective, observational study compared with data from the european region. | hospital-acquired pneumonia (hap) is associated with high mortality. in central europe, there is a dearth of information on the prevalence and treatment of hap. this project was aimed at collecting multicenter epidemiological data on patients with hap in the czech republic and comparing them with supraregional data. | 2016 | 27003315 |
| a retrospective study of the changing trends of antimicrobial resistance of klebsiella pneumoniae isolated from urine samples over last 3 years (2012-2014). | in our country, the problem of antibiotic resistance is compounding because of overuse and misuse of antibiotics. there is no systematic national surveillance of antibiotic resistance and insufficient data are available to quantify the problem. | 2017 | 27003967 |
| in vitro susceptibility pattern of extended spectrum β-lactamase producing gram negative bacilli against tetracyclines. | extended spectrum β-lactamases (esbls) are emerging as common nosocomial pathogens and important cause of mortality and morbidity, if not treated properly. the need of the hour is to find effective treatment options for dealing with esbl producing organisms. this study was aimed to evaluate in vitro susceptibility pattern of extended spectrum β-lactamase producers against tetracyclines. | 2016 | 27004323 |
| in vitro activity of a polyhexanide-betaine solution against high-risk clones of multidrug-resistant nosocomial pathogens. | to determine the in vitro activity of a polyhexanide-betaine solution against collection strains and multidrug-resistant (mdr) nosocomial isolates, including high-risk clones. | 2017 | 27004429 |
| isolation of enterobacter aerogenes carrying blatem-1 and blakpc-3 genes recovered from a hospital intensive care unit. | enterobacter aerogenes has recently emerged as an important hospital pathogen. in this study, we showed the emergence of e. aerogenes isolates carrying the blakpc gene in patients colonized by carbapenem-resistant klebsiella pneumoniae strains. two multiresistant e. aerogenes isolates were recovered from bronchial aspirates of two patients hospitalized in the intensive care unit at the "santa maria della scaletta" hospital, imola. the antimicrobial susceptibility test showed the high resistance ... | 2016 | 27004836 |
| new drugs for the treatment of complicated intra-abdominal infections in the era of increasing antimicrobial resistance. | the continuing increase in multidrug-resistant organisms (mdros) worldwide has created new challenges in treating complicated intra-abdominal infections (ciais). a number of novel antimicrobial agents have been developed against resistant pathogens. to target extended-spectrum β-lactamase (esbl)-producing pathogens, novel β-lactam antibiotics, such as ceftolozane/tazobactam, ceftazidime/avibactam, aztreonam/avibactam, imipenem/relebactam and s-649266, are antimicrobial alternatives for ciais. tw ... | 2016 | 27005457 |
| epidemiology and antimicrobial susceptibility profiles of pathogens causing urinary tract infections in the asia-pacific region: results from the study for monitoring antimicrobial resistance trends (smart), 2010-2013. | a total of 9599 isolates of gram-negative bacteria (gnb) causing urinary tract infections (utis) were collected from 60 centres in 13 countries in the asia-pacific region from 2010-2013. these isolates comprised enterobacteriaceae species (mainly escherichia coli, klebsiella pneumoniae, proteus mirabilis, klebsiella oxytoca, enterobacter cloacae and morganella morganii) and non-fermentative gnb species (predominantly pseudomonas aeruginosa and acinetobacter baumannii). in vitro susceptibilities ... | 2016 | 27005459 |
| carbapenemase-producing klebsiella pneumoniae bloodstream infections in neutropenic patients with haematological malignancies or aplastic anaemia: analysis of 50 cases. | carbapenemase-producing klebsiella pneumoniae (cp-kp) are currently among the most important nosocomial pathogens in many geographic regions. a retrospective study was conducted between 2010 and 2014 in four hospitals located in a high-prevalence area (athens, greece) to describe the clinical features, treatment and outcomes of neutropenic patients with haematological diseases complicated with cp-kp bloodstream infections. a total of 50 patients were identified, including 48 with haematological ... | 2016 | 27005460 |
| pediatric hypervirulent klebsiella pneumoniae septic arthritis. | cases of infection with hypervirulent klebsiella pneumoniae are gradually increasing in number, and cause life-threatening community-acquired infection even in immunocompetent patients. a 14-year-old boy developed septic hip arthritis due to hypervirulent k. pneumoniae (sequence type 23, serotype k1, maga positive). the patient initially seemed to have been successfully treated with antibiotics and surgical intervention, but septic arthritis developed into osteomyelitis of the femoral head and m ... | 2016 | 27005513 |
| ciprofloxacin-induced antibacterial activity is atteneuated by pretreatment with antioxidant agents. | ciprofloxacin works through interfering with replication and transcription of bacterial dna, which leads to increased oxidative stress, and death of bacterial cells. drugs with strong antioxidant such as tempol, melatonin and pentoxifylline might interfere with the antibacterial activity of ciprofloxacin. in the current study, the effect of these drugs on the cytotoxicity of ciprofloxacin was investigated against several reference bacteria. standard bacterial strains included escherichia coli at ... | 2016 | 27005666 |
| fecal carriage of extended-spectrum β-lactamases in healthy humans, poultry, and wild birds in león, nicaragua-a shared pool of blactx-m genes and possible interspecies clonal spread of extended-spectrum β-lactamases-producing escherichia coli. | antibiotic-resistant bacteria are a major concern in the healthcare of today, especially the increasing number of gram-negative bacteria producing β-lactamases such as extended-spectrum β-lactamases (esbls). however, little is known about the relationship of esbl producers in humans and domestic and wild birds, especially in a low-income setting. therefore, we studied the fecal carriage of esbl-producing escherichia coli and klebsiella pneumoniae in healthy humans, poultry, and wild birds in the ... | 2016 | 27007258 |
| normal vaginal bacterial flora of giant pandas (ailuropoda melanoleuca) and the antimicrobial susceptibility patterns of the isolates. | in order to study the typical vaginal bacterial flora of giant pandas (ailuropoda melanoleuca), we took vaginal swabs for the sake of bacterial isolation, from 24 healthy female giant pandas. a total of 203 isolates were identified, representing a total of 17 bacterial species. the most common bacteria isolated were lactobacillus spp. (54.2%, 13 of 24), followed by staphylococcus epidermidis (41.7%, 10 of 24) and escherichia coli (33.3%, 8 of 24). some opportunistic pathogenic bacteria, such as ... | 2016 | 27010307 |
| plant growth-promoting rhizobacteria inoculation to enhance vegetative growth, nitrogen fixation and nitrogen remobilisation of maize under greenhouse conditions. | plant growth-promoting rhizobacteria (pgpr) may provide a biological alternative to fix atmospheric n2 and delay n remobilisation in maize plant to increase crop yield, based on an understanding that plant-n remobilisation is directly correlated to its plant senescence. thus, four pgpr strains were selected from a series of bacterial strains isolated from maize roots at two locations in malaysia. the pgpr strains were screened in vitro for their biochemical plant growth-promoting (pgp) abilities ... | 2016 | 27011317 |
| susceptibility of contemporary isolates to fosfomycin: a systematic review of the literature. | the aim of this review was to evaluate the susceptibility of contemporary gram-positive and gram-negative bacteria to fosfomycin. pubmed and scopus databases were systematically searched to identify studies published in print or electronically from january 2010 until june 2015. in total, 84 studies were selected. susceptibility to fosfomycin of staphylococcus aureus ranged between 33.2% and 100% (frequency=91.7%, 95% confidence interval 88.7-94.9%), of enterococcus spp. from 30% to 100% (enteroc ... | 2016 | 27013000 |
| screening of furanone in cucurbita melo and evaluation of its bioactive potential using in silico studies. | the work presented here attempts to screen for the presence of 4-hydroxy-2,5-dimethyl-3(2h)-furanone in fruits and also any bioactive potential present in the fruit extracts. curcurbita melo was selected for the study, and the fruit was crushed, filtered and extracted with ethyl acetate as the solvent. the resulting extract was subjected to disk diffusion test using kirby bauer method for checking its antimicrobial potential. melon extract showed promising results against different clinical path ... | 2016 | 27013507 |
| laboratory detection and clinical implication of oxacillinase-48 like carbapenemase: the hidden threat. | carbapenemase producing gram-negative pathogen is of great concern for physician. the challenging aspects are treatment option and infection control. monitoring of respective carbapenemase resistance mechanism is necessary to prevent the outbreaks. currently, the rapid emergence of oxacillinase (oxa-48) like is alarming. increasing frequency of oxa-48 is seen than the classical carbapenemase (kpc, ndm, imp, and vim) across the world. the bla oxa-48 gene is commonly identified in escherichia coli ... | 2016 | 27013843 |
| dendrimers and polyamino-phenolic ligands: activity of new molecules against legionella pneumophila biofilms. | legionnaires' disease is a potentially fatal pneumonia caused by legionella pneumophila, an aquatic bacterium often found within the biofilm niche. in man-made water systems microbial biofilms increase the resistance of legionella to disinfection, posing a significant threat to public health. disinfection methods currently used in water systems have been shown to be ineffective against legionella over the long-term, allowing recolonization by the biofilm-protected microorganisms. in this study, ... | 2016 | 27014213 |
| comparison of hemagglutination and hemolytic activity of various bacterial clinical isolates against different human blood groups. | among the various pathogenic determinants shown by microorganisms hemagglutination and hemolysin production assume greater significance in terms of laboratory identification. this study evaluated the hemagglutination and hemolytic activity of various bacterial isolates against different blood groups. one hundred and fifty bacterial strains, isolated from clinical specimens like urine, pus, blood, and other body fluids were tested for their hemagglutinating and hemolytic activity against human a, ... | 2016 | 27014523 |
| community-onset extended-spectrum β-lactamase-producing enterobacteriaceae invasive infections in children in a university hospital in france. | limited data is available on pediatric community-onset infections with extended-spectrum β-lactamase-producing enterobacteriaceae (esbl-pe), but such infections may affect both the efficacy of empiric antibiotic therapy and the rational use of antibiotics.we retrospectively analyzed data from 2007 to 2012 for all children ≤16 years old with a positive esbl-pe strain from usually sterile sites within 48 hours of admission in a tertiary hospital in france. we analyzed healthcare- and community-ass ... | 2016 | 27015202 |
| risk factors for colonization by carbapenemase-producing enterobacteria at admission to a surgical icu: a retrospective study. | in 2011, a hospital-wide outbreak of oxa-48 producing klebsiella pneumoniae occurred in our hospital, an epidemiological setting of high esbl-producing k. pneumoniae rates. this study identifies risk factors for colonization with carbapenemase-producing enterobacteria (cpe) at surgical intensive care unit (sicu) admission. | 2016 | 27016135 |
| a case of hypermucoviscous klebsiella pneumoniae liver abscess syndrome in an iraqi male. | a 53-year-old man presented with fevers, productive cough and decreased appetite. he emigrated from iraq 4 years ago. chest x-ray revealed a left lung consolidation. respiratory cultures and two sets of blood cultures grew out pan-susceptible klebsiella pneumoniae liver ultrasound revealed a 6.4-cm complex lesion in the left hepatic lobe. a biopsy of the liver lesion produced bloody purulent aspirate; abscess cultures yielded a highly viscous pan-susceptible k. pneumoniae klebsiella pneumoniae l ... | 2016 | 27016535 |
| inhibitory potential of buffalo (bubalus bubalis) colostrum immunoglobulin g on klebsiella pneumoniae. | the unique components of colostrum like free oligosaccharides and glycoconjugates are known to offer resistance to enzymatic digestion in the gastrointestinal tract and have the ability to inhibit the localized adherence of enteropathogens to the digestive tract of the neonates. in this context, we have evaluated the in vitro effect of buffalo colostrum immunoglobulin g on human pathogen klebsiella pneumoniae, a predominant multidrug resistant pathogen associated with nasocomial infections. the ... | 2016 | 27017977 |
| [emphysematous cystitis and acute focal bacterial nephritis: a case report]. | a 96-year-old woman was diagnosed with colitis in our hospital. her past history was breast cancer and lung cancer but no diabetes mellitus. she suddenly complained of lower abdominal pain. abdominal computed tomography (ct) revealed intramural gas in the bladder wall and multiple poor contrasting area in her right kidney, which suggested emphysematous cystitis and acute focal bacterial nephritis. indwelling urethral catheter was performed for bladder drainage and the treatment with antibiotics ... | 2016 | 27018414 |
| comparison of short versus prolonged infusion of standard dose of meropenem against carbapenemase-producing klebsiella pneumoniae isolates in different patient groups: a pharmacokinetic-pharmacodynamic approach. | dose optimization is required to increase carbapenem's efficacy against carbapenemase-producing isolates. four clinical klebsiella pneumoniae isolates were used: one susceptible to meropenem with minimum inhibitory concentration (mic) 0.031 mg/l and 3 verona integron-borne metallo bete-lactamase-1-producing isolates with mics 8, 16, and 128 mg/l. the human pharmacokinetics of short (0.5-h) and prolonged (3-h) infusion regimens of 1 g meropenem every 8 h were simulated in an in vitro pharmacokine ... | 2016 | 27019965 |
| antimicrobial and antihyperlipidemic activities of isolated quercetin from anabaena aequalis(1). | this study aimed to isolate quercetin (for the first time) from anabaena aequalis borge, which inhabits soil surface of wadi el-alaqui protectorate located in aswan city, egypt. the isolated compound showed significant antibacterial activity against the gram-positive bacteria sarcina maxima and micrococcus kristinae, the gram-negative bacterium klebsiella pneumoniae, as well as against the filamentous fungus aspergillus flavus. the isolated compound was identified as quercetin using the structur ... | 2011 | 27020030 |
| bactericidal activity and mechanism of action of copper-sputtered flexible surfaces against multidrug-resistant pathogens. | using direct current magnetron sputtering (dcms), we generated flexible copper polyester surfaces (cu-pes) and investigated their antimicrobial activity against a range of multidrug-resistant (mdr) pathogens including eight gram-positive isolates (three methicillin-resistant staphylococcus aureus [mrsa], four vancomycin-resistant enterococci, one methicillin-resistant staphylococcus epidermidis) and four gram-negative strains (one extended-spectrum β-lactamase-producing [esbl] escherichia coli, ... | 2016 | 27020284 |
| susceptibility of klebsiella pneumoniae on coriander leaves to liquid- and vapor-phase ethanol. | the bio-control of ethanol on klebsiella pneumoniae on fresh coriander leaves for significantly reducing consumer health risk was investigated. washed and sterilized leaves of coriander were inoculated with k. pneumoniae cultured in trypticase soy broth. susceptibility of the k. pneumoniae to liquid- and evaporated vapor-phase ethanol (eve) was then examined in vitro complete inhibition of k. pneumoniae was found with 18% (v/v) liquid ethanol. exposure for 15 min to eve (9.00 ± 0.8 mmol l(-1)) c ... | 2016 | 27020413 |
| comparison of molecular and phenotypic methods for the detection and characterization of carbapenem resistant enterobacteriaceae. | in recent years, there has been a rapid dissemination of carbapenem resistant enterobacteriaceae (cre). this study aimed to compare phenotypic and molecular methods for detection and characterization of cre isolates at a large tertiary care hospital in saudi arabia. this study was carried out between january 2011 and november 2013 at the king khalid university hospital (kkuh) in saudi arabia. determination of presence of extended-spectrum beta-lactamases (esbl) and carbapenem resistance was in a ... | 2016 | 27020870 |
| do we need new antibiotics? | for several years, alarmist articles both in mass media and in the scientific community have reported an increase in antibiotic resistance, even citing an inability to treat patients infected with multidrug-resistant bacteria (mdr) responsible for high mortality worldwide. in this review we summarize and discuss the key points associated with the reality of (i) the existence of pandrug-resistant bacteria, (ii) the increase of resistance worldwide, (iii) the link between resistance and death, and ... | 2016 | 27021418 |
| can carbapenem-resistant enterobacteriaceae susceptibility results obtained from surveillance cultures predict the susceptibility of a clinical carbapenem-resistant enterobacteriaceae? | we evaluated the susceptibility profile of a colonizing carbapenem-resistant enterobacteriaceae to predict its susceptibility when recovered from a clinical specimen. an overall agreement of 88.7% (517 out of 583; 95% confidence interval, 85.8%-91.0%) was observed for the combinations of 11 antibiotics with 53 pairs of klebsiella pneumoniae carbapenemase-producing k pneumoniae (the only carbapenem-resistant enterobacteriaceae detected). very major errors were observed mainly for aminoglycoside a ... | 2016 | 27021509 |
| [particularities of liver abscesses in children in senegal: description of a series of 26 cases]. | liver abscess is a serious infection that can cause life-threatening complications. | 2016 | 27021881 |
| antitumor effects of cecropin b-lhrh' on drug-resistant ovarian and endometrial cancer cells. | luteinizing hormone-releasing hormone receptor (lhrhr) represents a promising therapeutic target for treating sex hormone-dependent tumors. we coupled cecropin b, an antimicrobial peptide, to lhrh', a form of lhrh modified at carboxyl-terminal residues 4-10, which binds to lhrhr without interfering with luteinizing hormone (lh) and follicle-stimulating hormone (fsh) secretion. this study aimed to assess the antitumor effects of cecropin b-lhrh' (cb-lhrh') in drug-resistant ovarian and endometria ... | 2016 | 27021903 |
| recent research examining links among klebsiella pneumoniae from food, food animals, and human extraintestinal infections. | klebsiella pneumoniae is a colonizer of livestock, a contaminant of retail meats and vegetables, and a cause of extraintestinal infections in humans. antibiotic-resistant strains of k. pneumoniae are becoming increasingly prevalent among hospital and community-acquired infections. antibiotics are used extensively in conventional food-animal production, where they select for antibiotic-resistant bacteria. antibiotic-resistant k. pneumoniae has been isolated from livestock as well as from a variet ... | 2016 | 27022987 |
| multidrug-resistant bacteria transmitted through high-density eeg in icu. | prevention of multidrug resistant (mdr) bacterial contamination remains a major challenge in icus. many hospital outbreaks involving mdr transmitted through environmental contamination have been reported. bedside high-density eeg allow for dynamic cognitive evaluation in brain-injured patients and is used more and more frequently in clinical practice to evaluate brain function and predict outcome in severely neurologically impaired patients. unfortunately, the material used for this procedure is ... | 2016 | 27023726 |
| influence of solid state fermentation by trichoderma spp. on solubility, phenolic content, antioxidant, and antimicrobial activities of commercial turmeric. | the influence of solid state fermentation (ssf) by trichoderma spp. on the solubility, total phenolic content, antioxidant, and antibacterial activities of turmeric was determined and compared with unfermented turmeric. the solubility of turmeric was monitored by increase in its phenolic content. the total phenolic content of turmeric extracted by 80% methanol and water after ssf by six species of trichoderma spp. increased significantly from 2.5 to 11.3-23.3 and from 0.5 to 13.5-20.4 gae/g dw, ... | 2016 | 27023794 |
| unique risks and clinical outcomes associated with extended-spectrum β-lactamase enterobacteriaceae in veterans with spinal cord injury or disorder: a case-case-control study. | objectives to describe the burden of extended-spectrum β-lactamase (esbl) enterobacteriaceae in veterans with spinal cord injury or disorder (sci/d), to identify risk factors for esbl acquisition, and to assess impact on clinical outcomes design retrospective case-case-control study patients and setting veterans with sci/d and utilization at a veterans' affairs medical center from january 1, 2012, to december 31, 2013. methods patients with a positive culture for esbl klebsiella pneumoniae, esch ... | 2016 | 27025908 |
| evaluation of different phenotypic techniques for the detection of slime produced by bacteria isolated from clinical specimens. | introduction : microorganisms use various strategies for their survival in both the environment and in humans. slime production by bacteria is one such mechanism by which microbes colonize on the indwelling prosthetic devices and form biofilms. infections caused by such microorganisms are difficult to treat as the biofilm acts as a shield and protects microbes against antimicrobial agents. there are several methods for the detection of slime produced by bacteria, and they include both phenotypic ... | 2016 | 27026830 |
| the klebsiella pneumoniae yfgl (bamb) lipoprotein contributes to outer membrane protein biogenesis, type-1 fimbriae expression, anti-phagocytosis, and in vivo virulence. | klebsiella pneumoniae is an opportunistic pathogen that causes several kinds of infections, including pneumonia, bacteremia, urinary tract infection and community-acquired pyogenic liver abscess (pla). adhesion is the critical first step in the infection process. our previous work demonstrated that the transcellular translocation is exploited by k. pneumoniae strains to migrate from the gut flora into other tissues, resulting in systemic infections. however, the initial stages of k. pneumoniae i ... | 2016 | 27029012 |
| risk factors for kpc-producing klebsiella pneumoniae vap: keep an eye on previous therapies! | 2016 | 27029825 | |
| activity of temocillin in a lethal murine model of infection of intra-abdominal origin due to kpc-producing escherichia coli. | temocillin is a 6-α-methoxy derivative of ticarcillin that shows in vitro activity against enterobacteriaceae producing klebsiella pneumoniae carbapenemase (kpc). our objective was to assess in vivo temocillin activity against kpc-producing escherichia coli. | 2016 | 27029848 |
| comparative effects of overproducing the arac-type transcriptional regulators mara, soxs, rara and rama on antimicrobial drug susceptibility in klebsiella pneumoniae. | in klebsiella pneumoniae, overproduction of rama and rara leads to increased mics of various antibiotics; mara and soxs are predicted to perform a similar function. we have compared the relative effects of overproducing these four arac-type regulators on envelope permeability (a combination of outer membrane permeability and efflux), efflux pump and porin production, and antibiotic susceptibility in k. pneumoniae. | 2016 | 27029850 |
| ciprofloxacin prophylaxis delays initiation of broad-spectrum antibiotic therapy and reduces the overall use of antimicrobial agents during induction therapy for acute leukaemia: a single-centre study. | due to an outbreak of extended-spectrum β-lactamase (esbl)-producing escherichia coli and klebsiella pneumoniae, the routine use of fluoroquinolone prophylaxis was questioned. as a result, this study was conducted with the aim to evaluate the impact of ciprofloxacin-prophylaxis on the use of broad-spectrum antibioctics and anti-mycotics. | 2016 | 27030917 |
| a retrospective study of risk factors for carbapenem-resistant klebsiella pneumoniae acquisition among icu patients. | carbapenem-resistant klebsiella pneumoniae (crkp) is rapidly emerging as a life-threatening nosocomial infection. in this study, we aim to identify risk factors, especially antibiotic use, for crkp infection among intensive care unit (icu) patients. | 2016 | 27031451 |
| the combined-disk boronic acid test as an accurate strategy for the detection of kpc carbapenemase in central america. | carbapenemase-producing klebsiella pneumoniae (kpc) outbreaks may cause a huge economical burden on developing countries. furthermore, kpc can be challenging to detect. we describe the laboratory strategy for the detection of kpc from 2011 to 2013 in a tertiary care hospital in central america with approximately 1,000 beds. | 2016 | 27031462 |
| high prevalence of new delhi metallo-β-lactamase-1 (ndm-1) producers among carbapenem-resistant enterobacteriaceae in kuwait. | the aim of the study was to determine the prevalence of new delhi metallo-β lactamase-1 (ndm-1) producing enterobacteriaceae in kuwait over a one year period. consecutive enterobacteriaceae isolates with reduced susceptibility to carbapenems were collected from four government hospitals in kuwait from january-december 2014. their susceptibility to 18 antibiotics was performed by determining the minimum inhibitory concentration. isolates resistant to carbapenems were tested by pcr for resistant g ... | 2016 | 27031521 |
| the investigation of oxacillinase/metallo-beta-lactamase genes and clonal analysis in carbapenem-resistant klebsiella pneumoniae. | infections due to carbapenem-resistant klebsiella pneumoniae represent a growing problem nationally. in our study, we aimed to examine carbapenem-resistant k. pneumoniae with multiple resistance isolated in the intensive care unit of our hospital. isolates were investigated for the presence of oxacillinase and metallo-beta lactamase genes with a view to determining the clonal relationship between the strains intensely over a short period. strain identification was completed with conventional met ... | 2016 | 27031897 |
| emergence of klebsiella pneumoniae st273 carrying blandm-7 and st656 carrying blandm-1 in manila, philippines. | we sought to determine the epidemiology of carbapenem-resistant enterobacteriaceae and to investigate the emergence of carbapenem-resistant klebsiella pneumoniae in two teaching hospitals in manila, philippines. we screened 364 enterobacteriaceae for carbapenem resistance between 2012 and 2013 and detected four carbapenem-resistant k. pneumoniae isolates from three different patients. we used whole genome sequencing to determine the antibiotic resistance profiles and confirmed the presence of ca ... | 2016 | 27032000 |
| biofilms associated with bowel necrosis: a newly recognised phenomenon in infants. | a biofilm is defined as a collection of organisms attached to a surface and surrounded by a matrix. | 2016 | 27032844 |
| innate lymphocyte/ly6c(hi) monocyte crosstalk promotes klebsiella pneumoniae clearance. | increasing antibiotic resistance among bacterial pathogens has rendered some infections untreatable with available antibiotics. klebsiella pneumoniae, a bacterial pathogen that has acquired high-level antibiotic resistance, is a common cause of pulmonary infections. optimal clearance of k. pneumoniae from the host lung requires tnf and il-17a. herein, we demonstrate that inflammatory monocytes are rapidly recruited to the lungs of k. pneumoniae-infected mice and produce tnf, which markedly incre ... | 2016 | 27040495 |
| high-level carbapenem-resistant oxa-48-producing klebsiella pneumoniae with a novel ompk36 variant and low-level, carbapenem-resistant, non-porin-deficient, oxa-181-producing escherichia coli from thailand. | five blaoxa-48-like-carrying enterobacteriaceae isolates collected from two thai patients in december 2012 were characterized. three klebsiella pneumoniae isolates giving two different pulsed-field gel electrophoresis patterns and sequence types (st11 and st37) from patient 1 harbored blaoxa-48 locating on tn1999.2, whereas two escherichia coli isolates with the same pulsotype and st5 from patient 2 carried isecp1-associated blaoxa-181. one k. pneumoniae strain had blashv-12, bladha-1, qnrb, and ... | 2016 | 27041106 |
| bioactivities of ethanolic extract and its fractions of cistus laurifolius l. (cistaceae) and salvia wiedemannii boiss. (lamiaceae) species. | cistus laurifolius l. (cistaceae) and salvia wiedemannii boiss. (lamiaceae) have been used for treatment of some illnesses in turkish folk medicine. in the present study, the ethanolic extract and its fractions obtained using re-extraction by hexane (hx), chloroform (chcl3), butanol, and remaining-water (r-h2o) of c. laurifolius were screened for their in vitro bioactivities. | 2016 | 27041865 |
| a neonatal septic arthritis case caused by klebsiella pneumoniae: a case report. | septic arthritis is encountered very rarely during the neonatal period and its diagnosis can delay because of atypical symptoms, thus it may lead to serious sequelae. the sequale can be prevented by early diagnosis and concomitant treatment. in neonates, pain can be experienced as a result of pseudoparalysis and of movement of the effected joints. a 17-day-old neonatal patient was brought to our hospital with complaint of unrest and then diagnosed with septic arthritis due to propagation of kleb ... | 2016 | 27042550 |
| recent advances in the laboratory detection of carbapenemase-producing enterobacteriaceae. | carbapenemase-producing enterobacteriaceae (cpe), mainly klebsiella pneumoniae and escherichia coli, have been increasing rapidly on a global scale and are considered to be significant health threats. the most common carbapenemases are kpcs, ndms, oxa-48-like, imps and vims but their distribution and prevalence differs between countries. the accurate, simple, cost effective and rapid detection of carbapenemases in clinical laboratories is an important initial step to control the spread of cpe wi ... | 2016 | 27042955 |
| combination regimens for treatment of carbapenem-resistant klebsiella pneumoniae bloodstream infections. | previous studies reported decreased mortality in patients with carbapenemase-producing klebsiella pneumoniae bloodstream infections (bsis) treated with combination therapy but included carbapenem-susceptible and -intermediate isolates, as per revised clsi breakpoints. here, we assessed outcomes in patients with bsis caused by phenotypically carbapenem-resistant k. pneumoniae (crkp) according to the number of in vitro active agents received and whether an extended-spectrum beta-lactam (bl) antibi ... | 2016 | 27044555 |
| cesarean section changes neonatal gut colonization. | delivery by means of cesarean section has been associated with increased risk of childhood immune-mediated diseases, suggesting a role of early bacterial colonization patterns for immune maturation. | 2016 | 27045582 |
| validation of a high-throughput screening assay for identification of adjunctive and directly acting antimicrobials targeting carbapenem-resistant enterobacteriaceae. | we describe development and validation of a high-throughput screen (hts) for identifying small molecules that restore the efficacy of carbapenems (adjunctives) and/or directly inhibit growth of carbapenem-resistant enterobacteriaceae (cre). our hts assay is based on a screen-counterscreen approach using a representative multidrug-resistant cre strain, klebsiella pneumoniae bidmc12a. specifically, we tested the ability of small molecules to inhibit bacterial growth in the presence (screen) or abs ... | 2016 | 27045615 |
| sonication of abdominal drains: clinical implications of quantitative cultures for the diagnosis of surgical site infection. | the use of drains in patients undergoing abdominal surgery has been a subject of debate for several decades. in this paper, the usefulness of quantitative cultures of sonicated abdominal drains for diagnosing surgical site of infection (ssi) and the association between culture results with patient outcome is evaluated. | 2016 | 27046739 |
| detection and characterization of extended-spectrum β-lactamases (blactx-m-1 and blashv ) producing escherichia coli, salmonella spp. and klebsiella pneumoniae isolated from humans in mizoram. | the present study was conducted to isolate and characterize the extended spectrum β-lactamases (esbls) producing enteric bacteria in human beings in mizoram, india. | 2015 | 27047141 |
| development of cefotaxime impregnated chitosan as nano-antibiotics: de novo strategy to combat biofilm forming multi-drug resistant pathogens. | frequent incidents of antibiotic-resistant biofilm forming pathogens in community-associated and hospital-acquired infections have become a global concern owing to failure of conventional therapies. nano-antibiotics (nabs) are de novo tools to overcome the multi-drug resistant mechanisms employed by the superbugs. inhibition of biofilm formation is one of those strategies to curb multi drug resistance phenomenon. in the current study, the anti-biofilm and antibacterial potential of newly synthes ... | 2016 | 27047457 |
| broad spectrum antimicrobial activity of forest-derived soil actinomycete, nocardia sp. pb-52. | a mesophilic actinomycete strain designated as pb-52 was isolated from soil samples of pobitora wildlife sanctuary of assam, india. based on phenotypic and molecular characteristics, the strain was identified as nocardia sp. which shares 99.7% sequence similarity with nocardia niigatensis ifm 0330 (nr_112195). the strain is a gram-positive filamentous bacterium with rugose spore surface which exhibited a wide range of antimicrobial activity against gram-positive bacteria including methicillin-re ... | 2016 | 27047463 |
| bronchiectasis: a bacteriological profile. | the occurrence of bronchiectasis can involve a combination of many environmental factors, including infection. the aim of our work is to determine the bacteriological profile of bronchiectasis. this is a retrospective study of 100 patients hospitalized in between january 2010 and july 2013. the average age was 48 years with a 58% female predominance. symptomatology was by a bronchial syndrome in 90% of cases. bacteriological examination was able to isolate the microbe in 35% of cases. in our stu ... | 2015 | 27047618 |
| population pharmacokinetics and probability of target attainment of meropenem in critically ill patients. | patients admitted to intensive care unit (icu) with klebsiella pneumoniae infections are characterized by high mortality. the aims of the present study were to investigate the population pharmacokinetics parameters and to assess the probability of target attainment of meropenem in critically ill patients to provide information for more effective regimens. | 2016 | 27048201 |
| emergence of kpc-producing klebsiella pneumoniae hypervirulent clone of capsular serotype k1 that belongs to sequence type 11 in mainland china. | kpc-2 has been rarely reported in hypervirulent klebsiella pneumoniae strains. here, we describe a kpc-2-producing k. pneumoniae hypervirulent clone of capsular serotype k1 belonging to sequence type 11. the presence of kpc carbapenemase in hypervirulent clone could mark an evolutionary step toward its establishment as major nosocomial pathogen. | 2016 | 27049969 |
| structure of a quinolone-stabilized cleavage complex of topoisomerase iv from klebsiella pneumoniae and comparison with a related streptococcus pneumoniae complex. | klebsiella pneumoniae is a gram-negative bacterium that is responsible for a range of common infections, including pulmonary pneumonia, bloodstream infections and meningitis. certain strains of klebsiella have become highly resistant to antibiotics. despite the vast amount of research carried out on this class of bacteria, the molecular structure of its topoisomerase iv, a type ii topoisomerase essential for catalysing chromosomal segregation, had remained unknown. in this paper, the structure o ... | 2016 | 27050128 |
| bacteriological profile and antibiotic susceptibility patterns of clinical isolates in a tertiary care cancer center. | this increased risk of bacterial infections in the cancer patient is further compounded by the rising trends of antibiotic resistance in commonly implicated organisms. in the indian setting this is particularly true in case of gram negative bacilli such as escherichia coli, klebsiella pneumoniae and acinetobacter spp. increasing resistance among gram positive organisms is also a matter of concern. the aim of this study was to document the common organisms isolated from bacterial infections in ca ... | 2017 | 27051152 |
| ultrasound transducer disinfection in emergency medicine practice. | external ultrasound transducer disinfection is common practice in medicine. unfortunately, clinically significant organisms, such as methicillin-resistant staphylococcus aureus (mrsa), pseudomonas aeruginosa, and klebsiella pneumonia spread throughout healthcare facilities via direct contact despite disinfection protocols. ultrasound transducers and coupling gel provide potential vectors for pathogen transmission, especially in immunocompromised and high-risk patient populations. our objective w ... | 2016 | 27051519 |
| successful treatment of a carbapenem-resistant klebsiella pneumoniae carrying bla oxa-48 , bla vim-2 , bla cmy-2 and bla shv- with high dose combination of imipenem and amikacin. | we describe a case of 58-year-old man with septic shock due to carbapenem-resistant klebsiella pneumoniae (cr-kp) bloodstream infections (bsi) who was successfully treated with a high dose association of amikacin and imipenem combined with continuous venovenous hemodiafiltration (cvvhdf). a klebsiella pneumoniae (kp) was isolated from the catheter culture and from two blood samples, drawn from the catheter before removal and from a peripheral vein. the kp was intermediate to amikacin (mic = 16 μ ... | 2016 | 27051575 |
| cost attributable to nosocomial bacteremia. analysis according to microorganism and antimicrobial sensitivity in a university hospital in barcelona. | to calculate the incremental cost of nosocomial bacteremia caused by the most common organisms, classified by their antimicrobial susceptibility. | 2016 | 27055117 |
| copper-coated textiles: armor against mdr nosocomial pathogens. | soft surfaces in the health-care setting harbor potentially pathogenic bacteria and fungi that can be transferred to patients and personnel. we evaluated the in vitro antimicrobial efficacy of two types of innovative copper-coated textiles against a variety of nosocomial multi-drug resistant (mdr) pathogens. five isolates each of mdr staphylococcus aureus, klebsiella pneumoniae, pseudomonas aeruginosa, acinetobacter baumannii and enterococcus faecium as well as three candida parapsilosis were te ... | 2016 | 27055400 |
| complete genome sequence of kpc-3- and ctx-m-15-producing klebsiella pneumoniae sequence type 307. | klebsiella pneumoniaesequence type (st) 307, carryingblakpc-3,blactx-m-15,blaoxa-1,aac(6')-ib-cr, andqnrb1 genes, is replacing the predominant hyperepidemic st258 clone in italy. whole-genome and complete plasmid sequencing of one st307 strain was performed and new features were identified. | 2016 | 27056222 |
| overexpressions of xyla and xylb in klebsiella pneumoniae lead to enhanced 1,3-propanediol production by cofermentation of glycerol and xylose. | 1,3-propanediol (1,3-pd) is a valuable platform compound. many studies have shown that the supplement of nadh plays a key role in the bioproduction of 1,3-pd from klebsiella pneumoniae. in this study, the xyla and xylb genes from escherichia coli were overexpressed individually or simultaneously in k. pneumoniae to improve the production of 1,3-pd by cofermentation of glycerol and xylose. compared with the parent strain, the xylose consumption was significantly increased by the introduction of t ... | 2016 | 27056473 |
| evolution of antibiotic multiresistance in escherichia coli and klebsiella pneumoniae isolates from urinary tract infections: a 12-year analysis (2003-2014). | the aim of this study was to identify multi-drug resistance (mdr) in the main enterobacteriaceae implicated in urinary tract infections (escherichia coli and klebsiella pneumoniae) from both, community and hospitalized patients and to analyze the evolution over a 12-year period. | 2016 | 27056582 |
| surveillance of wisconsin antibacterial susceptibility patterns. | antimicrobial resistance presents a threat to quality patient care. knowledge of localantibacterial susceptibility patterns can guide clinicians in empiric antibacterial administration andassist pharmacists and infectious disease physicians in development of appropriate therapeutic pathways. | 2016 | 27057577 |
| [comparison of the modified hodge test and the carba np test for detection of carbapenemases in enterobacteriaceae isolates]. | a rapid, practical, and accurate identification of carbapenemase-producing enterobacteriaceae isolates is crucial for the implementation of appropriate infection control measures and proper treatment of the infections. for this purpose, a large number of phenotypic test methods have been developed, although none has 100% sensitivity and specificity. variations in sensitivity and specificity of these tests based on the type of beta-lactamase enzymes carried by that isolates might result in differ ... | 2016 | 27058324 |
| [investigation of carbapenemases in carbapenem-resistant escherichia coli and klebsiella pneumoniae strains isolated in 2014 in turkey]. | carbapenems are the choice of treatment in infections caused by multidrug resistant enterobacteriaceae. in recent years carbapenem-resistant enterobacteriaceae isolates due to carbapenemases have been increasingly reported worldwide. multicenter studies on carbapenemases are scarce in turkey. the aim of this study was to determine the distribution of carbapenemases from different parts of turkey as a part of the european survey of carbapenemase producing enterobacteriaceae (euscape) project. beg ... | 2016 | 27058326 |
| [role of bacteriobilia in postoperative complications]. | at present there is a controversy regarding the impact of positive bile cultures on morbidity and mortality rates, and on the incidence of readmissions in patients with biliar disease. the aim of this study was to evaluate the role of bacteriobilia in postoperatory infections, mortality or readmissions in these patients. | 2016 | 27062981 |
| multidrug-resistant combined infections in a liver transplanted patient: case report. | we report a case of successfully treated multiple liver abscesses in a liver-transplanted patient, sustained by combined multidrug-resistant infections. two months after a liver transplant, a computed tomography scan revealed the presence of multiple abscesses in the liver graft. blood cultures and abscessual liver fluid were both positive for acquired colistin- and carbapenem- resistant klebsiella pneumoniae and an extended-spectrum of beta-lactamases-producing enterobacter aerogenes. the treat ... | 2016 | 27063638 |
| understanding, preventing and eradicating klebsiella pneumoniae biofilms. | the ability of pathogenic bacteria to aggregate and form biofilm represents a great problem for public health, since they present extracellular components that encase these micro-organisms, making them more resistant to antibiotics and host immune attack. this may become worse when antibiotic-resistant bacterial strains form biofilms. however, antibiofilm screens with different compounds may reveal potential therapies to prevent/treat biofilm infections. here, we focused on klebsiella pneumoniae ... | 2016 | 27064296 |
| further spread of bla ndm-5 in enterobacteriaceae via incx3 plasmids in shanghai, china. | one hundred and two carbapenem-resistant enterobacteriaceae (cre) strains were isolated in a teaching hospital in shanghai, china from 2012 to 2015. in a follow-up study, four new delhi metallo-β-lactamase-5 (ndm-5)-producing strains were identified after screening these cre strains, including 1 klebsiella pneumoniae strain (rj01), 1 proteus mirabilis strain (rj02), and 2 escherichia coli strains (rj03 and rj04). all k. pneumoniae and e. coli isolates were resistant to carbapenems, third-generat ... | 2016 | 27065982 |
| community spread of extended-spectrum β-lactamase-producing bacteria detected in social insurance hospitals throughout japan. | we surveyed the status of community-acquired infections involving four extended-spectrum β-lactamase (esbl)-producing bacteria (escherichia coli, klebsiella pneumoniae, klebsiella oxytoca, proteus mirabilis) isolated from clinical specimens from 11 social insurance hospitals in japan in 2012. these are member hospitals of the japan community healthcare organization, an independent administrative hospital organization. the isolation rates for e. coli, k. pneumoniae, k. oxytoca, and p. mirabilis w ... | 2016 | 27066881 |
| amino acid substitutions of crrb responsible for resistance to colistin through crrc in klebsiella pneumoniae. | colistin is a last-resort antibiotic for treatment of carbapenem-resistant klebsiella pneumoniae a recent study indicated that missense mutations in the crrb protein contribute to colistin resistance. in our previous study, mechanisms of colistin resistance were defined in 17 of 26 colistin-resistant k. pneumoniae clinical isolates. of the remaining nine strains, eight were highly resistant to colistin. in the present study, crrab sequences were determined for these eight strains. six separate a ... | 2016 | 27067316 |
| paradoxical effect of polymyxin b: high drug exposure amplifies resistance in acinetobacter baumannii. | administering polymyxin antibiotics in a traditional fashion may be ineffective against gram-negative eskape (enterococcus faecium, staphylococcus aureus, klebsiella pneumoniae, acinetobacter baumannii, pseudomonas aeruginosa, and enterobacter species) pathogens. here, we explored increasing the dose intensity of polymyxin b against two strains of acinetobacter baumannii in the hollow-fiber infection model. the following dosage regimens were simulated for polymyxin b (t1/2 = 8 h): non-loading do ... | 2016 | 27067330 |
| initial assessment of the molecular epidemiology of blandm-1 in colombia. | we report complete genome sequences of four blandm-1-harboring gram-negative multidrug-resistant (mdr) isolates from colombia. the blandm-1 genes were located on 193-kb inc fia, 178-kb inc a/c2, and 47-kb (unknown inc type) plasmids. multilocus sequence typing (mlst) revealed that these isolates belong to sequence type 10 (st10) (escherichia coli), st392 (klebsiella pneumoniae), and st322 and st464 (acinetobacter baumannii and acinetobacter nosocomialis, respectively). our analysis identified th ... | 2016 | 27067339 |
| antibiofilm peptides: potential as broad-spectrum agents. | the treatment of bacterial diseases is facing twin threats, with increasing bacterial antibiotic resistance and relatively few novel compounds or strategies under development or entering the clinic. bacteria frequently grow on surfaces as biofilm communities encased in a polymeric matrix. the biofilm mode of growth is associated with 65 to 80% of all clinical infections. it causes broad adaptive changes; biofilm bacteria are especially (10- to 1,000-fold) resistant to conventional antibiotics an ... | 2016 | 27068589 |
| in vitro antibacterial activity of zno and nd doped zno nanoparticles against esbl producing escherichia coli and klebsiella pneumoniae. | pure zno and neodymium (nd) doped zno nanoparticles (nps) were synthesized by the co-precipitation method. the synthesized nanoparticles retained the wurtzite hexagonal structure. from fesem studies, zno and nd doped zno nps showed nanorod and nanoflower like morphology respectively. the ft-ir spectra confirmed the zn-o stretching bands at 422 and 451 cm(-1) for zno and nd doped zno nps respectively. from the uv-vis spectroscopic measurement, the excitonic peaks were found around 373 nm and 380 ... | 2016 | 27071382 |
| successful doxycycline therapy in a patient with escherichia coli and multidrug-resistant klebsiella pneumoniae urinary tract infection. | to report on a patient with a symptomatic, polymicrobial escherichia coli and multidrug-resistant (mdr), extended-spectrum β-lactamase (esbl)-positive klebsiella pneumoniae urinary tract infection (uti) who was successfully treated with oral doxycycline hyclate. | 2016 | 27071978 |
| fermentative production of 1-propanol from d-glucose, l-rhamnose and glycerol using recombinant escherichia coli. | fermentative production of 1-propanol, which is one of the promising precursors of polypropylene production, from d-glucose, l-rhamnose and glycerol using metabolically engineered escherichia coli was examined. to confer the ability to produce 1-propanol from 1,2-propanediol (1,2-pd) in recombinant e. coli, a part of the pdu regulon including the diol dehydratase and the propanol dehydrogenase genes together with the adenosylcobalamin (adocbl) regeneration enzyme genes of klebsiella pneumoniae w ... | 2016 | 27072298 |
| dissemination of the blakpc gene by clonal spread and horizontal gene transfer: comparative study of incidence and molecular mechanisms. | in addition to the global spread of the kpc-producing klebsiella pneumoniae (kpc-kp) clonal complex (cc)-258 clone, the blakpc gene may also spread by horizontal gene transfer (hgt), as suspected when more than one kpc-producing enterobacteriaceae (kpc-ent) species are isolated in a single patient. we aimed to characterize the incidence and molecular features of kpc-kp that were isolated alone (singular kpc-kp) versus kpc-kp that were isolated together with another kpc-ent species (joint kpc-kp) ... | 2016 | 27073266 |
| clinical and molecular analysis of klebsiella pneumoniae causing liver abscess in china. | hypervirulent klebsiella pneumoniae (hvkp) has been characterized as the major pathogen associated with the development of liver abscesses. although the prevalence of k. pneumoniae in liver abscesses in chinese patients is on the rise, methods for the early laboratory identification and recognition of hvkp are lacking, and hvkp detection and surveillance are thus limited. | 2016 | 27073997 |
| what does the susceptible-dose dependent interpretive category for cefepime in esbl-producing bacteria? | in this study, we investigated the frequency of isolates included in the susceptible-dose dependent (sdd) category, according to the clinical and laboratory standards institute guidelines, carrying blatem, blashv and blactx genes among 92 klebsiella pneumoniae and 80 enterobacter cloacae clinical isolates. the presence of one or more extended-spectrum β-lactamases (esbls) genes was observed in 64% k. pneumoniae and 69% e. cloacae isolates. nineteen isolates were included in sdd interpretive cate ... | 2016 | 27077929 |
| frequency, antimicrobial resistance and genetic diversity of klebsiella pneumoniae in food samples. | this study aimed to assess the frequency of klebsiella pneumoniae in food samples and to detect antibiotic resistance phenotypes, antimicrobial resistance genes and the molecular subtypes of the recovered isolates. a total of 998 food samples were collected, and 99 (9.9%) k. pneumoniae strains were isolated; the frequencies were 8.2% (4/49) in fresh raw seafood, 13.8% (26/188) in fresh raw chicken, 11.4% (34/297) in frozen raw food and 7.5% (35/464) in cooked food samples. antimicrobial resistan ... | 2016 | 27078494 |