Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| impact of regional vein thrombosis in patients with klebsiella pneumoniae liver abscess. | klebsiella liver abscess (kla) is an emerging infection in asia caused by hypermucoviscous strains of klebsiella pneumoniae. it is associated with thrombophlebitis of portal and hepatic veins. the natural history and role of anticoagulation for this regional thrombophlebitis is unclear. in a retrospective study of 169 subjects with kla over 7 years, thrombophlebitis was identified in 53/169 (31.4%). only 1 received therapeutic anticoagulation. despite this 30/49 (73.2%) of those with follow up s ... | 2015 | 26444702 |
| emergence of st147 klebsiella pneumoniae producing oxa-204 carbapenemase in a university hospital, tunisia. | molecular features of the first carbapenem-resistant klebsiella pneumoniae isolates (kp1 and kp2) from the university hospital tahar sfar, tunisia, were investigated. antimicrobial susceptibility testing, multilocus sequence typing, s1 nuclease pulsed-field gel electrophoresis, southern blot, and polymerase chain reaction (pcr)-based replicon typing were performed. extended-spectrum β-lactamases and carbapenemase genes were detected by pcr and sequencing. both isolates were multidrug resistant. ... | 2016 | 26447939 |
| structure-activity relationship of amino acid tunable lipidated norspermidine conjugates: disrupting biofilms with potent activity against bacterial persisters. | the emergence of bacterial resistance and biofilm associated infections has created a challenging situation in global health. in this present state of affairs where conventional antibiotics are falling short of being able to provide a solution to these problems, development of novel antibacterial compounds possessing the twin prowess of antibacterial and antibiofilm efficacy is imperative. herein, we report a library of amino acid tunable lipidated norspermidine conjugates that were prepared by ... | 2015 | 26452096 |
| effect of treatment with an overheated dry-saturated steam vapour disinfection system on multidrug and extensively drug-resistant nosocomial pathogens and comparison with sodium hypochlorite activity. | the development of portable steam generators has made disinfection of the environment more practical. this study assessed the "in vitro" ability of an overheated dry-saturated steam vapour system to kill multidrug and extensively-drug resistant nosocomial pathogens, defining the antimicrobial spectrum and the contact times compared with the activity of sodium hypochlorite. | 2015 | 26452549 |
| first outbreak of oxa-48-positive carbapenem-resistant klebsiella pneumoniae isolates in constantine, algeria. | 2015 | 26453148 | |
| hypervirulent klebsiella pneumoniae clones causing bacteraemia in adults in a teaching hospital in barcelona, spain (2007-2013). | virulent hypermucoviscous klebsiella pneumoniae strains associated with the maga and rmpa genes have mainly emerged in asia. we analysed the frequency and the clinical and molecular epidemiology of k. pneumoniae bacteraemia isolates obtained over a 7-year period (2007-2013). fifty-three of 878 k. pneumoniae invasive isolates (5.4%) showed a hypermucoviscous phenotype (by the string test). of these, 16 (30.2%) were maga(+)/rmpa(+), 12 (22.6%) were maga(-)/rmpa(+), and the remaining 25 (47.2%) wer ... | 2016 | 26454059 |
| diversity, antimicrobial and antioxidant activities of culturable bacterial endophyte communities in aloe vera. | twenty-nine culturable bacterial endophytes were isolated from surface-sterilized tissues (root, stem and leaf) of aloe vera and molecularly characterized to 13 genera: pseudomonas, bacillus, enterobacter, pantoea, chryseobacterium, sphingobacterium, aeromonas, providencia, cedecea, klebsiella, cronobacter, macrococcus and shigella. the dominant genera include bacillus (20.7%), pseudomonas (20.7%) and enterobacter (13.8%). the crude and ethyl acetate fractions of the metabolites of six isolates, ... | 2015 | 26454221 |
| the epidemiology of carbapenem-resistant klebsiella pneumoniae colonization and infection among long-term acute care hospital residents. | objective an improved understanding of carbapenem-resistant klebsiella pneumoniae (crkp) in long-term acute care hospitals (ltachs) is needed. the objective of this study was to assess risk factors for colonization or infection with crkp in ltach residents. methods a case-control study was performed at a university-affiliated ltach from 2008 to 2013. cases were defined as all patients with clinical cultures positive for crkp and controls were those with clinical cultures positive for carbapenem- ... | 2016 | 26455382 |
| clinical manifestations and bacteriological features of culture-proven gram-negative bacterial arthritis. | to investigate the clinical manifestations and bacteriological features of culture-proven, gram-negative bacterial arthritis. | 2015 | 26455489 |
| tracing of false negative results in phenotypic methods for identification of carbapenemase by real-time pcr. | carbapenemase production causes multi antibiotics resistant in gram-negative bacteria. a simple rapid and accurate phenotypic test for detection of gram-negative carbapenemase-producing bacteria is useful for the treatment of infections. the aim of this study was to track the negative results in carbapenemase phenotypic test by real-time pcr. | 2016 | 26456106 |
| predicting abscesses in adults with community-onset monomicrobial enterobacteriaceae bacteremia: microorganisms matters. | enterobacteriaceae is a leading pathogen of community-onset bacteremia. this study aims to establish a predictive scoring algorithm to identify adults with community-onset enterobacteriaceae bacteremia who are at risk for abscesses. of the total 1262 adults, 152 (12.0%) with abscess occurrence were noted. the 6 risk factors significantly associated with abscess occurrence-liver cirrhosis, diabetes mellitus, thrombocytopenia and high c-reactive protein (>100 mg/l) at bacteremic onset, delayed def ... | 2016 | 26456388 |
| increasing incidence of extended-spectrum β-lactamase-producing escherichia coli in community hospitals throughout the southeastern united states. | objective to describe the epidemiology of extended-spectrum β-lactamase (esbl)-producing escherichia coli (esbl-ec) and klebsiella pneumoniae (esbl-kp) infections design retrospective cohort setting inpatient care at community hospitals patients all patients with esbl-ec or esbl-kp infections methods esbl-ec and esbl-kp infections from 26 community hospitals were prospectively entered into a centralized database from january 2009 to december 2014. results a total of 925 infections caused by esbl ... | 2016 | 26458226 |
| successful international clones of blactx-m-15-producing klebsiella pneumoniae with coexpression of plasmid-mediated quinolone resistance (pmqr) determinants in tehran hospitals. | the dissemination of plasmid-mediated multidrug resistance in enterobacteriaceae is a major public health concern. we investigated the prevalence of plasmid-mediated quinolone resistance (pmqr), 16s rrna methylases, ctx-m, and acquired ampc enzymes in esbl-producing klebsiella pneumoniae (n=40) from tehran hospitals. plasmid replicon typing, pulsed-field gel electrophoresis (pfge), and multilocus sequence typing (mlst) were carried out for typing. ctx-m group 1 (confirmed as bla(ctx-m-15) in sel ... | 2015 | 26458278 |
| coproduction of kpc-2 and qnrb19 in klebsiella pneumoniae st340 isolate in brazil. | few reports described the presence of bla(kpc) and qnr genes in the same isolate. this study reports the combination of bla(kpc-2) and qnrb19 genes in klebsiella pneumoniae st340 isolate in brazil. these findings draw attention to this combination in st340 isolate, which is part of the cc258, disseminated in latin america. | 2015 | 26458280 |
| retrospective study for risk factors for febrile uti in spinal cord injury patients with routine concomitant intermittent catheterization in outpatient settings. | retrospective study. | 2016 | 26458969 |
| antibacterial properties of 3-(phenylsulfonyl)-2-pyrazinecarbonitrile. | the emergence of multidrug-resistant bacterial strains has heightened the need for new antimicrobial agents based on novel chemical scaffolds that are able to circumvent current modes of resistance. we recently developed a whole-animal drug-screening methodology in pursuit of this goal and now report the discovery of 3-(phenylsulfonyl)-2-pyrazinecarbonitrile (pspc) as a novel antibacterial effective against resistant nosocomial pathogens. the minimum inhibitory concentrations (mic) of pspc again ... | 2015 | 26459212 |
| tigecycline lock therapy for catheter-related bloodstream infection caused by kpc-producing klebsiella pneumoniae in two pediatric hematological patients. | catheter-related bacteremias carry high mortality rates in hematological patients. when a multidrug-resistant microorganism is involved, the catheter should ideally be removed; however, this approach is not always possible. tigecycline lock therapy was used in two pediatric oncohematological patients with intravascular catheter-related infection due to kpc-producing klebsiella pneumoniae. the catheter was salvaged in both cases, and the patients were later discharged. our experience suggests the ... | 2015 | 26459892 |
| preservation of acquired colistin resistance in gram-negative bacteria. | colistin-resistant mutants were obtained from 17 colistin-susceptible strains of acinetobacter baumannii, pseudomonas aeruginosa, klebsiella pneumoniae, and escherichia coli. the stability of colistin resistance in these mutants was investigated. three of four colistin-resistant p. aeruginosa mutants recovered colistin susceptibility in colistin-free medium; however, colistin-susceptible revertants were obtained from only one strain each of a. baumannii and e. coli. no susceptible revertants wer ... | 2015 | 26459897 |
| cooccurrence of multiple ampc β-lactamases in escherichia coli, klebsiella pneumoniae, and proteus mirabilis in tunisia. | over a period of 40 months, plasmid-mediated ampc β-lactamases were detected in tunis, tunisia, in 78 isolates (0.59%) of escherichia coli, klebsiella pneumoniae, and proteus mirabilis. in 67 isolates, only one ampc gene was detected, i.e., blacmy-2-type (n = 33), blaacc (n = 23), bladha (n = 6) or blaebc (n = 5). multiple ampc genes were detected in 11 isolates, with the following distribution: blamox-2, blafox-3, and blacmy-4/16 (n = 6), blafox-3 and blamox-2 (n = 3), and blacmy-4 and blamox-2 ... | 2015 | 26459902 |
| using an adenosine triphosphate bioluminescent assay to determine effective antibiotic combinations against carbapenem-resistant gram negative bacteria within 24 hours. | current in vitro combination testing methods involve enumeration by bacterial plating, which is labor-intensive and time-consuming. measurement of bioluminescence, released when bacterial adenosine triphosphate binds to firefly luciferin-luciferase, has been proposed as a surrogate for bacterial counts. we developed an atp bioluminescent combination testing assay with a rapid turnaround time of 24h to determine effective antibiotic combinations. | 2015 | 26460891 |
| evaluation of dna binding, radicals scavenging and antimicrobial studies of newly synthesized n-substituted naphthalimides: spectroscopic and molecular docking investigations. | in this study, we investigated a new series of naphthalimide based schiff base compounds as potential dna binding, antioxidant and antimicrobial agents. the structural characterization of synthesized compounds was carried out with the aid of elemental analysis and spectroscopic techniques (uv-vis., ir, (1)h and (13)c nmr). the dna binding properties of target compounds against ct-dna (calf thymus) have been investigated in detail by numerous biophysical techniques (uv-vis, fluorescence, ethidium ... | 2015 | 26462815 |
| antibiofilm agents against mdr bacterial strains: is bioactive glass bag-s53p4 also effective? | the treatment of bone and joint infections is challenging due to the presence of bacterial biofilm and the increasing emergence of multiresistant strains. bag-s53p4 is a bone substitute that is characterized by osteoconductive and antimicrobial properties. the aim of this study was to assess the effectiveness of bag-s53p4 against biofilm produced in vitro by multiresistant bacterial strains. | 2016 | 26462989 |
| prevalence and molecular characterization of carbapenemase-producing gram-negative bacteria from a university hospital in china. | the increasing emergence of carbapenem resistance in gram-negative bacteria associated with carbapenemase prompted the initiation of this study. | 2016 | 26463362 |
| massive pneumoretroperitoneum arising from emphysematous cholecystitis: a case report and the literature review. | emphysematous cholecystitis is a severe variant of acute cholecystitis caused by anaerobic bacteria. although intraperitoneal air as a complication has been described in association with emphysematous cholecystitis, pneumoretroperitoneum arising from emphysematous cholecystitis is extremely rare. herein, we describe a rare case of pneumoretroperitoneum arising from emphysematous cholecystitis that was successfully treated with emergency surgery. | 2015 | 26463667 |
| necrotizing fasciitis in patients with diabetes mellitus: clinical characteristics and risk factors for mortality. | necrotizing fasciitis (nf) is a rapidly progressive and life-threatening infection. this study aimed to investigate the clinical characteristics and mortality- associated factors in diabetic patients. | 2015 | 26463900 |
| trends in the annual incidence of carbapenem-resistant klebsiella pneumoniae bloodstream infections: a 8-year retrospective study in a large teaching hospital in northern italy. | bloodstream infections (bsi) due to carbapenem-resistant (c-r) klebsiella pneumoniae (kp) are of global concern from both clinical and public health standpoints. this retrospective study aimed to describe c-r kp bsi epidemiology in a large teaching hospital in northern italy. | 2015 | 26464061 |
| aminoglycoside therapy for childhood urinary tract infection due to extended-spectrum β-lactamase-producing escherichia coli or klebsiella pneumoniae. | the rate of urinary tract infections (utis) due to extended-spectrum β-lactamase (esbl)-producing bacterial strains requiring carbapenem therapy has been increasing in children. this study was conducted to evaluate the effect of non-carbapenem antibiotic therapy on childhood utis caused by esbl-producing escherichia coli or klebsiella pneumoniae. | 2015 | 26464143 |
| etiological diagnosis of community-acquired pneumonia in adult patients: a prospective hospital-based study in mashhad, iran. | pneumonia is the third most common cause of death in the world, and mortality is highest for patients who require hospitalization. | 2015 | 26464771 |
| metabolic engineering of klebsiella pneumoniae for the production of 2-butanone from glucose. | 2-butanone is an important commodity chemical of wide application in different areas. in this study, klebsiella pneumoniae was engineered to directly produce 2-butanone from glucose by extending its native 2, 3-butanediol synthesis pathway. to identify the potential enzyme for the efficient conversion of 2, 3-butanediol to 2-butanone, we screened different glycerol dehydratases and diol dehydratases. by introducing the diol dehydratase from lactobacillus brevis and deleting the ldha gene encodin ... | 2015 | 26465746 |
| urinary tract infection and indwelling urinary catheters: prospective study in gynecological surgery with antibiotic prophylaxis. | urinary tract infections are the most common cause of hospital-acquired infections, and the use of indwelling urinary catheters is a predisposing factor for their development. the aims of this study were to estimate the frequency of pre and postoperative bacteriuria, identify the microorganisms involved, count the colony-forming units, determine the antibiotic sensitivity profile and compare the results from pre and postoperative urinalyses among women undergoing gynecological surgery with impla ... | 2016 | 26465812 |
| study on bacterial strains causing blood and urinary tract infections in the neonatal intensive care unit and determination of their antibiotic resistance pattern. | infections are considered as one of the main factors of neonatal mortality, especially in developing countries. blood and urine infections are one of the most prevalent infectious factors among the infants. on the other hand, resistance against antimicrobial factors is one of the major problems in the world, and it is important to be informed about antibiotic resistance pattern of microorganisms for treatment of infections. | 2015 | 26468359 |
| [acid-base modulation of lysozyme activity in medium for cultivation of enterobacteria]. | determination of modulating effect of acid-base state of medium for cultivation of enterobacteria on activity of c-type lysozyme. | 2015 | 26470418 |
| inhibition of recbcd in klebsiella pneumoniae by gam and its effect on the efficiency of gene replacement. | gam protein is an inhibitor of the host recbcd exonuclease, and this inhibition is essential to the proficiency of red recombinase-mediated gene replacement. in klebsiella pneumoniae, the efficiency of this gene replacement was lower than that in escherichia coli, and the minimum length of homologous extensions required was longer. thus, it was supposed that the inhibitory effect of gam against recbcd was weak in k. pneumoniae. to test this hypothesis, a gam-deficient red recombinase expression ... | 2016 | 26471352 |
| abdominal surgical site infection due to klebsiella pneumoniae carbapenemase-producing k. pneumoniae. | 2016 | 26471477 | |
| genomic identification of nitrogen-fixing klebsiella variicola, k. pneumoniae and k. quasipneumoniae. | it was difficult to differentiate klebsiella pneumoniae, k. quasipneumoniae and k. variicola by biochemical and phenotypic tests. genomics increase the resolution and credibility of taxonomy for closely-related species. here, we obtained the complete genome sequence of the k. variicola type strain dsm 15968(t) (=f2r9(t)). the genome of the type strain is a circular chromosome of 5,521,203 bp with 57.56% gc content. from 540 klebsiella strains whose genomes had been publicly available as at 3 mar ... | 2016 | 26471769 |
| efficacy of two-time prophylactic intravenous administration of tazobactam/piperacillin for transrectal ultrasound-guided needle biopsy of the prostate. | prevalence of fluoroquinolone (fq)-resistant escherichia coli has been recently increasing worldwide. we analyzed the incidence and characteristics of acute bacterial prostatitis after transrectal ultrasound-guided needle prostate biopsy (trusp-bx) with prophylactic tazobactam/piperacillin (taz/pipc) treatment as an alternative regimen. | 2015 | 26473153 |
| synthesis, evaluation and molecular docking studies of amino acid derived n-glycoconjugates as antibacterial agents. | six amino acid derived n-glycoconjugates of d-glucose were synthesized, characterized and tested for antibacterial activity against g(+)ve (bacillus cereus) as well as g(-)ve (escherichia coli and klebsiella pneumoniae) bacterial strains. all the tested compounds exhibited moderate to good antibacterial activity against these bacterial strains. the results were compared with the antibacterial activity of standard drug chloramphenicol, where results of a5 (tryptophan derived glycoconjugates) agai ... | 2015 | 26476390 |
| stepwise evolution of pandrug-resistance in klebsiella pneumoniae. | carbapenem resistant enterobacteriaceae (cre) pose an urgent risk to global human health. cre that are non-susceptible to all commercially available antibiotics threaten to return us to the pre-antibiotic era. using single molecule real time (smrt) sequencing we determined the complete genome of a pandrug-resistant klebsiella pneumoniae isolate, representing the first complete genome sequence of cre resistant to all commercially available antibiotics. the precise location of acquired antibiotic ... | 2015 | 26478520 |
| defining extended spectrum β-lactamases: implications of minimum inhibitory concentration-based screening versus clavulanate confirmation testing. | while the clinical and laboratory standards institute (clsi) recommends against routine screening for extended spectrum β-lactamases (esbls), knowledge of these data can provide valuable insights regarding epidemiology and drug therapy decisions. the purpose of this study was to compare the impact of minimum inhibitory concentration (mic)-based screening versus phenotypic confirmatory testing of esbls on the susceptibility profile of selected antimicrobials. | 2015 | 26481506 |
| activity of ceftaroline and comparators against pathogens isolated from skin and soft tissue infections in latin america - results of aware surveillance 2012. | as part of the assessing worldwide antimicrobial resistance evaluation (aware) surveillance program in 2012 the in vitro activity of ceftaroline and relevant comparator antimicrobials was evaluated in six latin american countries (argentina, brazil, chile, colombia, mexico and venezuela) against pathogens isolated from patients with hospital associated skin and soft tissue infections (sstis). the study documented that ceftaroline was highly active (mic90 0.25mg/l/% susceptible 100%) against meth ... | 2015 | 26481631 |
| development of a two-step process for production of 3-hydroxypropionic acid from glycerol using klebsiella pneumoniae and gluconobacter oxydans. | in this work, a two-step process was developed for the production of 3-hydroxypropionic acid from glycerol. in the first step, glycerol was converted to 1,3-propanediol by klebsiella pneumonia. in the second step, the 1,3-propanediol was converted into 3-hydroxypropionic acid by gluconobacter oxydans. in a 7.0 l bioreactor, the whole process took 54 h, consumed 480 g glycerol and produced 242 g 3-hydroxypropionic acid. the conversion rate of glycerol to 3-hydroxypropionic acid was 50.4 % (g g(-1 ... | 2015 | 26481922 |
| genomic characteristics of ndm-producing enterobacteriaceae isolates in australia and their blandm genetic contexts. | blandm has been reported in different enterobacteriaceae species and on numerous plasmid replicon types (inc). plasmid replicon typing, in combination with genomic characteristics of the bacterial host (e.g., sequence typing), is used to infer the spread of antimicrobial resistance determinants between genetically unrelated bacterial hosts. the genetic context of blandm is heterogeneous. in this study, we genomically characterized 12 ndm-producing enterobacteriaceae isolated in australia between ... | 2015 | 26482302 |
| molecular characterization of carbapenem-nonsusceptible enterobacterial isolates collected during a prospective interregional survey in france and susceptibility to the novel ceftazidime-avibactam and aztreonam-avibactam combinations. | an interregional surveillance program was conducted in the northwestern part of france to determine the prevalence of carbapenem-nonsusceptible enterobacteriaceae (cnse) isolates and their susceptibility to ceftazidime-avibactam and aztreonam-avibactam combinations. nonduplicate cnse clinical isolates were prospectively collected from six hospitals between june 2012 and november 2013. mics of ceftazidime and aztreonam, alone or combined with a fixed concentration of avibactam (4 μg/ml), and thos ... | 2015 | 26482307 |
| antimicrobial susceptibilities of aerobic and facultative gram-negative bacilli from intra-abdominal infections in patients from seven regions in china in 2012 and 2013. | to evaluate the antimicrobial susceptibility of gram-negative bacilli that caused hospital-acquired and community-acquired intra-abdominal infections (iais) in china between 2012 and 2013, we determined the susceptibilities to 12 antimicrobials and the extended-spectrum β-lactamase (esbl) statuses of 3,540 iai isolates from seven geographic areas in china in a central laboratory using clsi broth microdilution and interpretive standards. most infections were caused by escherichia coli (46.3%) and ... | 2015 | 26482308 |
| detection of carbapenemases in clinical enterobacteriaceae isolates using the vitek ast-n202 card. | the rapid and accurate detection of carbapenemase-producing enterobacteriaceae (cpe) in clinical microbiology laboratories is essential for the treatment and control of infections caused by these microorganisms. this study was performed to evaluate the ability of the vitek ast-n202 card to detect cpe isolates. | 2015 | 26483990 |
| blandm-1 carriage on incr plasmid in enterobacteriaceae strains. | four ndm-1-producing enterobacteriaceae strains (three klebsiella pneumoniae and one citrobacter koseri) were isolated between 2009 and 2011 through a nationwide surveillance for carbapenem-resistant enterobacteriaceae in croatia to study the molecular genetic background of blandm and the responsible plasmid types. phenotypically, the clinical strains proved to be multidrug resistant. all strains remained susceptible to tigecycline and colistin. the clinical strains harbored variable antibiotic ... | 2016 | 26484384 |
| maldi-tof mass spectrometry and blakpc gene phylogenetic analysis of an outbreak of carbapenem-resistant k. pneumoniae strains. | carbapenem-resistant klebsiella pneumoniae isolates are an important cause of nosocomial infections. this study evaluated a rapid cost-saving method based on maldi-tof technology, was and compared it with phenotypic, genotypic and epidemiological data for characterization of kpc-kp strains consecutively isolated during a supposed outbreak. twenty-five consecutive kpc klebsiella pneumoniae isolates were identified and clustered by the maldi biotyper (bruker, daltonics). to display and rank the va ... | 2015 | 26485012 |
| correction: emergence of oxa-48-producing klebsiella pneumoniae in taiwan. | 2015 | 26485653 | |
| ultrastructural changes in clinical and microbiota isolates of klebsiella pneumoniae carriers of genes bla shv, bla tem, bla ctx-m, or bla kpc when subject to β-lactam antibiotics. | the aim of this study was to characterize the ultrastructural effects caused by β-lactam antibiotics in klebsiella pneumoniae isolates. three k. pneumoniae clinical isolates were selected for the study with resistance profiles for third-generation cephalosporins, aztreonam, and/or imipenem and with different resistance genes for extended-spectrum β-lactamases (esbl) or klebsiella pneumoniae carbapenemase (kpc). two k. pneumoniae isolates obtained from the microbiota, which were both resistant to ... | 2015 | 26491715 |
| the challenge of antibiotic resistance in haematology patients. | bacterial infections were once a major obstacle to the treatment of acute leukaemia. improvement in management strategies, including the use of broad-spectrum antibacterial drugs targeting gram-negative bacteria, has reduced the mortality in neutropenic patients developing blood stream infections and other severe infections. in many countries these achievements are threatened by development of multi-resistant bacteria, such as klebsiella pneumoniae, pseudomonas aeruginosa and methicillin-resista ... | 2016 | 26492511 |
| pneumonia caused by klebsiella spp. in 46 horses. | klebsiella spp. are implicated as a common cause of bacterial pneumonia in horses, but few reports describe clinical presentation and disease progression. | 2015 | 26492860 |
| [a case of delayed-onset multiple metastatic infection following liver abscess]. | klebsiella pneumoniae liver abscess has a tendency to spread to distant sites early in the course of disease and to involve multiple organs synchronously. a 59-year-old male was admitted because of liver abscess accompanied by fever and abdominal pain. the patient underwent percutaneous catheter drainage and received intravenous antibiotics. symptom relief was achieved after the treatment as well as marked reduction in the size of the abscess. despite proper treatment of the liver abscess, howev ... | 2015 | 26493511 |
| antibiotic susceptibility of commensal bacteria from human milk. | recent studies have focused on foodborne or commensal bacteria as vehicles of antibiotic resistance. however, the antibiotic resistance of milk bacteria from healthy donors is still vague in taiwan. for this purpose, human milk samples were obtained from randomly recruited 19 healthy women between 3 and 360 days post-partum. antibiotic susceptibility profile of bacteria from milk samples was determined. about 20 bacterial species were isolated from milk samples including staphylococcus (6 specie ... | 2016 | 26494365 |
| antioxidant, antibacterial activity, and phytochemical characterization of melaleuca cajuputi extract. | the threat posed by drug-resistant pathogens has resulted in the increasing momentum in research and development for effective alternative medications. the antioxidant and antibacterial properties of phytochemical extracts makes them attractive alternative complementary medicines. therefore, this study evaluated the phytochemical constituents of melaleuca cajuputi flower and leaf (gf and gl, respectively) extracts and their antioxidant and antibacterial activities. | 2015 | 26497742 |
| antibiotic consumption and resistance: results of the spin-uti project of the gisio-siti. | to evaluate trends and association between antibiotic consumption and resistance during an eight-year period, from 2006 to 2013. | 2015 | 26499423 |
| multi drug resistant klebsiella isolates in burn patients: a comparative study. | infections are the most common complications in the burn patients admitted to the hospitals leading to high morbidity and mortality. klebsiella is one of the most frequently isolated bacteria from burn wounds. | 2015 | 26500905 |
| hemodialysis catheter heat transfer for biofilm prevention and treatment. | central line-associated bloodstream infections (clabsis) are not easily treated, and many catheters (e.g., hemodialysis catheters) are not easily replaced. biofilms (the source of infection) on catheter surfaces are notoriously difficult to eradicate. we have recently demonstrated that modest elevations of temperature lead to increased staphylococcal susceptibility to vancomycin and significantly soften the biofilm matrix. in this study, using a combination of microbiological, computational, and ... | 2017 | 26501916 |
| optical scatter patterns facilitate rapid differentiation of enterobacteriaceae on chromagar™ orientation medium. | enterobacteriaceae family comprised pathogens and commensals and has a significant impact on food safety and public health. enterobacteriaceae is often enumerated and presumptively identified on chromogenic media, such as chromagar(tm) orientation medium based on colony profile; however, classification is highly arbitrary, and some could not be differentiated due to similar chromogen production. here, we investigated the ability of the laser optical sensor, bardot (bacterial rapid detection usin ... | 2015 | 26503189 |
| a two-year surveillance in five colombian tertiary care hospitals reveals high frequency of non-cg258 clones of carbapenem-resistant klebsiella pneumoniae with distinct clinical characteristics. | the global spread of carbapenem-resistant klebsiella pneumoniae (cr-kp) has been largely associated with sequence type 258 (st258) and its related variants (clonal group 258 [cg258]). here we describe the molecular epidemiology of cr-kp from five tertiary care hospitals in medellín, the second largest city in colombia. all cr-kp-infected patients admitted from june 2012 to june 2014 were included (n = 193). patients' clinical information was obtained from medical records. carbapenemase kpc, vim, ... | 2015 | 26503660 |
| in vitro activity of ceftaroline against bacterial pathogens isolated from skin and soft tissue infections in europe, russia and turkey in 2012: results from the assessing worldwide antimicrobial resistance evaluation (aware) surveillance programme. | the objective of this study was to analyse antimicrobial susceptibility testing data generated by the assessing worldwide antimicrobial resistance evaluation (aware) global surveillance programme for pathogens causing skin and soft tissue infections (sstis) in european countries in 2012. | 2016 | 26503667 |
| multidrug resistant enterobacteriaceae and extended spectrum β-lactamase producing escherichia coli: a cross-sectional study in national kidney center, nepal. | emergence of antibacterial resistance and production of extended spectrum β-lactamases (esbls) are responsible for the frequently observed empirical therapy failures. most countries have experienced rapid dissemination of esbls producing enterobacteriaceae isolates, particularly e. coli and klebsiella pneumoniae. esbls are clinically significant and when detected, indicate the need for the use of appropriate antibacterial agents. but antibacterial choice is often complicated by multi-resistance. | 2015 | 26504518 |
| carriage of class 1 and 2 integrons in quinolone, extended-spectrum-β-lactamase-producing and multi drug resistant e.coli and k.pneumoniae: high burden of antibiotic resistance. | the study aimed at assessing any association between quinolone resistance, mdr and esbl production and their relation with the presence of integrons in esherichia coli and klebsiella pneumoniae. | 2015 | 26504755 |
| klebsiella pneumoniae o antigen loss alters the outer membrane protein composition and the selective packaging of proteins into secreted outer membrane vesicles. | klebsiella pneumoniae is a nosocomial pathogen which naturally secretes lipopolysaccharide (lps) and cell envelope associated proteins into the environment through the production of outer membrane vesicles (omvs). the loss of the lps o antigen has been demonstrated in other bacterial species to significantly alter the composition of omvs. therefore, this study aimed to comprehensively analyze the impact of o antigen loss on the sub-proteomes of both the outer membrane and secreted omvs from k. p ... | 2015 | 26505306 |
| analysis of the drug-resistant characteristics of klebsiella pneumoniae isolated from the respiratory tract and ctx-m esbl genes. | the main aim of this study was to understand the relationship between the drug-resistant characteristics of klebsiella pneumoniae and ctx-m-type extended spectrum β-lactamases (esbls), and to detect the distributions of ctx-m-type esbls in clinically isolated strains. ctx-m esbl genes isolated from the clinical samples were amplified by polymerase chain reaction and identified by sequence analysis; the antibiotic susceptibility of the samples was determined using the kirby-bauer disc-diffusion m ... | 2015 | 26505351 |
| extended-spectrum β-lactamase-producing enterobacteriaceae among pregnant women in norway: prevalence and maternal-neonatal transmission. | to study (i) the prevalence and risk factors for carriage of extended-spectrum β-lactamase-producing enterobacteriaceae (esbl-e) in pregnant women, (ii) the maternal-neonatal transmission rate of esbl-e at birth and (iii) the prevalence of esbl-e in expressed breast milk of colonized mothers. | 2015 | 26507147 |
| occult klebsiella pneumoniae bacteremia at emergency department: a single center experience. | patients with undetected bacteremia when discharged from a hospital are considered to have occult bacteremia. klebsiella pneumoniae bacteremia (kpb) is endemic to taiwan. our purpose was to study the impact of occult kpb. | 2015 | 26510516 |
| epidemiological study of community- and hospital-acquired intraabdominal infections. | to investigate and analyze the clinical and etiological characteristics of community-acquired intraabdominal infections (ciais) and hospital-acquired or nosocomial intraabdominal infections (niais) in a comprehensive hospital, to understand the characteristics, pathogen composition, and drug resistance of ciais as well as niais, and to provide a reference for clinical treatment. | 2015 | 26511299 |
| pediatric extended spectrum β-lactamase infection: community-acquired infection and treatment options. | infection caused by extended spectrum β-lactamase (esbl)-producing enterobacteriaceae in pediatric patients has been increasing and spreading to the community, compromising the options for effective antibiotics. this retrospective study was conducted to identify which antibiotics esbl-producing enterobacteriaceae remain susceptible to. in addition, the prevalence of community-acquired infection caused by these organisms, and the possibility of association between these organisms and septic shock ... | 2016 | 26513341 |
| emergency room: an unrecognized source of extended-spectrum β-lactamase producing escherichia coli and klebsiella pneumoniae. | extended-spectrum β-lactamase (esbl)-producing escherichia coli and klebsiella pneumoniae are the leading causes of hospital-associated infections, but community-acquired cases are increasingly being reported. this study determined the prevalence of esbl-producing e. coli and k. pneumoniae carriers, their bla genes and risk factors of 452 patients admitted to the emergency room (er) of ramathibodi hospital, mahidol university, bangkok, thailand between april and august 2011. prevalence of esbl-p ... | 2015 | 26513905 |
| frequency and antimicrobial susceptibility of pathogens at tertiary public hospital, sao paulo, brazil. | nosocomial infections are one of the leading causes of morbidity and mortality. this study determined both prevalence and antimicrobial susceptibility of microorganisms identified during january to december 2012 at a tertiary public hospital, sao paulo, brazil. data, hospital length of stay, age, identity of microorganisms, and antimicrobial susceptibilities were obtained from patients' records. a total of 724 positive strains were obtained from different body sites. gram-negative microorganisms ... | 2015 | 26513931 |
| quantification and comparison of virulence and characteristics of different variants of carbapenemase-producing klebsiella pneumoniae clinical isolates from taiwan and the united states. | the emergence of klebsiella pneumoniae carbapenemase (kpc)-producing strains is a challenge for clinicians. the characteristics and virulence of variants of kpc-producing k. pneumoniae isolates were evaluated. | 2016 | 26514941 |
| isolation, identification and screening of antimicrobial thermophilic streptomyces sp. al-dhabi-1 isolated from tharban hot spring, saudi arabia. | the strain streptomyces sp. al-dhabi-1 was isolated from soil sediments collected from tharban hot spring in the southern west of saudi arabia using actinomycetes isolation agar and starch casein agar at 55 °c. identification of the isolate was done according to morphological, physiological and biochemical characteristics and 16s rrna sequence similarity as well. 16s rrna sequence and blast analyses confirmed that the isolate belonging to the genus streptomyces. the sequence was submitted to gen ... | 2016 | 26515082 |
| pharmacokinetic/pharmacodynamic target attainment of intravenous β-lactam regimens against gram-negative bacteria isolated in a brazilian teaching hospital. | monte carlo simulations have been used for selecting optimal antibiotic regimens for treatment of bacterial infections. the aim of this study was to assess the pharmacokinetic and pharmacodynamic target attainment of intravenous β-lactam regimens commonly used to treat bloodstream infections (bsis) caused by gram-negative rod-shaped organisms in a brazilian teaching hospital. | 2015 | 26516962 |
| mutant prevention concentration of tigecycline for klebsiella pneumoniae isolates with four different resistance statuses. | 2015 | 26517496 | |
| a single-day point-prevalence study of faecal carriers in long-term care hospitals in madrid (spain) depicts a complex clonal and polyclonal dissemination of carbapenemase-producing enterobacteriaceae. | the objective of this study was to describe the prevalence and microbiological characteristics of carbapenemase-producing enterobacteriaceae (cpe) colonizing patients in long-term care hospitals (ltchs) in madrid, spain. | 2016 | 26518051 |
| lateral dissemination and inter-patient transmission of blakpc-3: role of a conjugative plasmid in spreading carbapenem resistance. | the objective of this study was to describe the nosocomial spread of carbapenemase-producing enterobacteria and characterize a plasmid involved in kpc dissemination. | 2016 | 26518052 |
| bacteremic community-acquired infections due to klebsiella pneumoniae: clinical and microbiological presentation in new caledonia, 2008-2013. | to provide data on severe bacteremic community-acquired infections due to klebsiella pneumoniae in new caledonia. | 2015 | 26518064 |
| evaluation of the efficiency of hospital antibiotic policy applied dr jan biziel university hospital no 2 in bydgoszcz in 2009-2013. | the hospital infection control team (hict) of dr jan biziel university hospital no 2 in bydgoszcz developed and implemented the principles of a rational antibiotic therapy in 2008. a behavior algorithm has worked since 01.10.2008. implementation of the principles of a rational antibiotic therapy was part of the hospital antibiotic policy. | 2015 | 26519850 |
| chemical composition and antimicrobial activity of honeybee (apis mellifera ligustica) propolis from subtropical eastern australia. | propolis is a material manufactured by bees and contains beeswax, bee salivary secretions and plant resins. propolis preparations have been used for millennia by humans in food, cosmetics and medicines due to its antibacterial effects. within the hive, propolis plays an important role in bees' health, with much of its bioactivity largely dependent on the plant resins the bees select for its production. few chemical studies are available on the chemistry of propolis produced by australian honeybe ... | 2015 | 26521267 |
| environmental persistence of oxa-48-producing klebsiella pneumoniae in a french intensive care unit. | the spread of carbapenemase-producing gram-negative rods is an emerging global problem. this study describes the epidemiologic features of an outbreak caused by an environmental reservoir of oxa-48-producing klebsiella pneumoniae caused by persistence of the bacteria during 20 months in an intensive care unit in france. this report emphasizes the importance of early environmental screening to interrupt the transmission of carbapenemase-producingenterobacteriaceae. | 2016 | 26521704 |
| whole-cell-based identification of electrochemically active bacteria in microbial fuel cells by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. | electrochemically active bacteria (eab) that are capable of producing electricity from renewable biomass and organic wastes have been of particular interest in recent years. methods for selective enrichment, accurate identification and easy acquisition of eab fingerprints for phylogenetic characterization would facilitate utilization of these bioenergy-producing species in practical environmental engineering applications. | 2015 | 26522312 |
| m2b monocytes provoke bacterial pneumonia and gut bacteria-associated sepsis in alcoholics. | chronic alcohol consumption markedly impairs host antibacterial defense against opportunistic infections. γ-irradiated nod-scid il-2rγ(null) mice inoculated with nonalcoholic pbmcs (control pbmc chimeras) resisted klebsiella pneumonia and gut bacteria-associated sepsis, whereas the chimeras created with alcoholic pbmcs (alcoholic pbmc chimeras) were very susceptible to these infections. m1 monocytes (il-12(+)il-10(-)cd163(-)cd14(+) cells), major effector cells in antibacterial innate immunity, w ... | 2015 | 26525287 |
| double copies of bla(kpc-3)::tn4401a on an incx3 plasmid in klebsiella pneumoniae successful clone st512 from italy. | a carbapenem-resistant sequence type 512 (st512) klebsiella pneumoniae carbapenemase 3 (kpc-3)-producing k. pneumoniae strain showing a novel variant plasmid content was isolated in palermo, italy, in 2014. st512 is a worldwide successful clone associated with the spread of bla(kpc) genes located on the incfiik pkpqil plasmid. in our st512 strain, the bla(kpc-3) gene was unusually located on an incx3 plasmid, whose complete sequence was determined. two copies of bla(kpc-3)::tn4401a caused by int ... | 2015 | 26525794 |
| the spread of bla oxa-48 and bla oxa-244 carbapenemase genes among klebsiella pneumoniae, proteus mirabilis and enterobacter spp. isolated in moscow, russia. | the spread of carbapenemase-producing enterobacteriaceae (cpe) is a great problem of healthcare worldwide. study of the spread for bla oxa-48-like genes coding epidemically significant carbapenemases among hospital pathogens is important for the regional and global epidemiology of antimicrobial resistance. | 2015 | 26526183 |
| colistin-resistant enterobacteriaceae bacteraemia: real-life challenges and options. | 2016 | 26526298 | |
| etiology of community acquired pneumonia among children in india: prospective, cohort study. | childhood community acquired pneumonia (cap) is a significant problem in developing countries, and confirmation of microbial etiology is important for individual, as well as public health. however, there is paucity of data from a large cohort, examining multiple biological specimens for diverse pathogens (bacteria and viruses). the community acquired pneumonia etiology study (capes) was designed to address this knowledge gap. | 2015 | 26528392 |
| directed evolution and resolution mechanism of 1, 3-propanediol oxidoreductase from klebsiella pneumoniae toward higher activity by error-prone pcr and bioinformatics. | 1, 3-propanediol oxidoreductase (pdor) is a key enzyme in glycerol bioconversion to 1,3-propanediol (1, 3-pd) which is a valuable chemical and one of the six new petrochemical products. we used error-prone pcr and activity screening to identify mutants of klebsiella pneumoniae (k. pneumoniae) pdor with improved activity. the activity of one of the identified mutants, pdor'-24, which includes a single mutation, a199s, was 48 u/mg, 4.9 times that of the wild-type enzyme. molecular docking was perf ... | 2015 | 26528716 |
| comparison of direct hospitalization costs and length of stay in carbapenem resistant versus carbapenem sensitive klebsiella pneumoniae infections in a tertiary care hospital. | 2015 | 26533266 | |
| ongoing increasing temporal and geographical trends of the incidence of extended-spectrum beta-lactamase-producing enterobacteriaceae infections in france, 2009 to 2013. | extended-spectrum beta-lactamase-producing enterobacteriaceae (esbl-e) are a major focus of multidrug-resistant organisms (mro) surveillance programmes in france. to describe the temporal and geographical trends of these pathogens, we conducted an epidemiological study based on data extracted from the nationwide mro surveillance network from 2009 to 2013. during this time, the incidence of esbl-e infections in french hospitals increased by 73%, from 0.35 to 0.60 per 1,000 patient days (pd) (p<0. ... | 2015 | 26536042 |
| isolation of an ndm-5-producing st16 klebsiella pneumoniae from a dutch patient without travel history abroad, august 2015. | a new delhi metallo-beta-lactamase-5 (ndm-5)-producing st16 klebsiella pneumoniae strain was isolated from a dutch patient in a long-term care facility without recent travel history abroad. core genome multilocus sequence typing (cgmlst) revealed that the dutch isolate was clonally related to isolates detected in four patients in denmark in 2014. public health experts and clinicians need to be informed; repetitive screening may be needed in patients without known risk factors for carbapenemases- ... | 2015 | 26537842 |
| prevalence of qnr and aac(6')-ib-cr genes in clinical isolates of klebsiella pneumoniae from imam hussein hospital in tehran. | plasmid mediated quinolone resistance (pmqr) has been shown to play an important role in resistance not only to quinolones, but also β-lactams and aminoglycosides. in fact, qnr genes are frequently carried along with β-lactamase determinants on the same plasmids. we studied the prevalence of qnra, qnrb, qnrs and aac(6')-ib-cr genes among quinolone and cephalosporin resistant clinical isolates of klebsiella pneumoniae (k. pneumoniae), as well as the association between pmqr genes with resistance ... | 2015 | 26538780 |
| antibiotic trends of klebsiella pneumoniae and acinetobacter baumannii resistance indicators in an intensive care unit of southern italy, 2008-2013. | the overuse of antimicrobials is one of the main factors responsible for the development and spread of antimicrobial resistance, together with other causes, such as intra- and inter-hospital spread of resistant microorganisms and infection control policies and practices. the objective of the present study is to report the trends of klebsiella pneumoniae and acinetobacter baumannii antimicrobial resistance indicators in an italian intensive care unit (icu) during a six-year period, from 2008 to 2 ... | 2015 | 26539294 |
| bacteriological profile and antibiotic susceptibility pattern of neonatal sepsis at a teaching hospital in bayelsa state, nigeria. | sepsis is one of the most common causes of neonatal hospital admissions and is estimated to cause 26% of all neonatal deaths worldwide. while waiting for results of blood culture, it is necessary to initiate an empirical choice of antibiotics based on the epidemiology of causative agents and antibiotic sensitivity pattern in a locality. | 2015 | 26543394 |
| prevalence survey of nosocomial infections in the inner mongolia autonomous region of china [2012-2014]. | to investigate the prevalence of nosocomial infections, the distribution of nosocomial infection sites, the use of antibiotic and the situation of detected nosocomial infection pathogens in the inner mongolia autonomous region of china from 2012 to 2014, to grasp the current conditions of regional nosocomial infections in timely, for the development of infection prevention and control measures to provide a basis for effective hospital. | 2015 | 26543614 |
| chronic klebsiella pneumonia: a rare manifestation of klebsiella pneumonia. | k. pneumoniae can present as two forms of community-acquired pneumonia, acute and chronic. although acute pneumonia may turn into necrotizing pneumonia, which results in a prolonged clinical course, it often has a rapidly progressive clinical course. in contrast, chronic klebsiella pneumonia runs a protracted indolent course that mimics other chronic pulmonary infections and malignancies. herein, we present two cases of chronic klebsiella pneumonia. the diagnosis was made by microorganism identi ... | 2015 | 26543615 |
| antibacterial activities of fagara macrophylla, canarium schweinfurthii, myrianthus arboreus, dischistocalyx grandifolius and tragia benthamii against multi-drug resistant gram-negative bacteria. | bacterial infections caused by multidrug resistant phenotypes constitute a worldwide health concern. the present study was designed to evaluate the in vitro antibacterial activities of the methanol extracts of five medicinal plants: fagara macrophylla, canarium schweinfurthii, myrianthus arboreus, dischistocalyx grandifolius and tragia benthamii against a panel of 28 multidrug resistant gram-negative bacterial strains. the liquid broth microdilution was used to determine the minimal inhibitory c ... | 2015 | 26543702 |
| comprehensive clinical and epidemiological assessment of colonisation and infection due to carbapenemase-producing enterobacteriaceae in spain. | most available information on carbapenemase-producing enterobacteriaceae (cpe) is usually associated with specific types of infection or patient or with descriptions of outbreaks. the aim of this study was to comprehensively analyse the clinical epidemiology, clinical features and outcomes of colonisation and infections due to cpe in spain. | 2016 | 26546855 |
| cloning, expression, mutagenesis library construction of glycerol dehydratase, and binding mode simulation of its reactivase with ligands. | the production of 1, 3-propanediol (1, 3-pd) and 3-hydroxypropionaldehyde (3-hpa) by enzyme reaction has been a hot field, and glycerol dehydratase (gdht) is the key and rate-limiting enzyme involved in their biosynthesis. the gldabc gene encoding gdht was cloned from klebsiella pneumoniae, and the activity of the corresponding proteins expressed extracellularly and intracellularly was 6.8 and 3.2 u/mg, respectively, about six and three times higher than that of the wild strain. the change of am ... | 2016 | 26547853 |
| control of klebsiella pneumoniae pulmonary infection and immunomodulation by oral treatment with the commensal probiotic bifidobacterium longum 5(1a). | klebsiella pneumoniae (kp) a common cause of pneumonia leads to intense lung injury and mortality that are correlated with infective exacerbations. probiotics are a class of microorganisms that have immunomodulatory effects to benefit health. we investigated whether the probiotic bifidobacterium longum 5(1a) induces protection in mice against lung infection induced by kp and the potential involved mechanisms. kp infection induced secretion of pro-inflammatory cytokines, neutrophil recruitment, s ... | 2016 | 26548605 |
| severe pneumonia in the elderly: a multivariate analysis of risk factors. | pneumonia is the second leading reason for hospitalization of medicare beneficiaries. the mortality rate is high, especially in the elderly. in this study, we aimed to determine the risk factors associated with severe pneumonia in the elderly. retrospective study was conducted and data of old patients with severe pneumonia were collected. they were divided into two groups: the experiment group (death group) and the control (living group). the general situation, underlying diseases, laboratory te ... | 2015 | 26550157 |