| [bacteriological studies on mecillinam (author's transl)]. | | 1977 | 192923 |
| integration and regulation of mitochondrial assembly in yeast. | the interactions between the mitochondrial and nucleocytoplasmic systems required for mitochondriogenesis have been investigated at several different levels. those involved in the formation of functional enzyme complexes have been studied using cytochrome oxidase: this multimeric (2 x 7 and 2 x 6 subunits for enzymes from yeast and beef heart respectively) has been resolved, and the mitochondrial contribution has been shown to be dispensible for catalytic function proper. using novel mutants, wi ... | 1977 | 192997 |
| [etiology of acute respiratory infection in hospitalized children (author's transl)]. | incidence of respiratory tract infection represents 23% of the total number of admissions between 1-24 months of age, during a period of 18 months. the diagnosis were: bronchiolities, 143 cases; bronchopneumonia, 134 cases; tracheobronchitis, 50 cases; laryngitis, four cases, and bacterial pneumonia, 61 cases. monthly incidence was maximal in december of each year. from the total group, 144 cases were included in the present study to determine etiology of the infection. in 19% of the cases a ser ... | 1976 | 193420 |
| failure to find beta-adrenergic receptor binding in guinea pig cerebral cortex with [3h]dihydroalprenolol. | | 1977 | 193615 |
| cell surface markers on epithelial-burkitt hybrid cells superinfected with epstein-barr virus. | attempts were made to superinfect two epithelial-burkitt hybrid cell lines, designated d98/hr-1 and d98/raji, with epstein-barr virus (ebv) and to investigate the expression of some cell surfacr markers including histocompatibility antigens, and the presence of b-cell markers, such as receptors for the third complement component and for monkey red blood cells. successful superinfection of d98/hr-1 cells with ebv was made evident by the expression of early antigen and, to a lesser extent, virus c ... | 1977 | 193641 |
| effect of storage, different media constituents and dilution of axenic medium on the growth of axenic culture of entamoeba histolytica. | | 1977 | 193783 |
| human nasal epithelial cell culture system: evaluation of response to human interferons. | this report describes the response of human nasal epithelial cells to exogenously applied human interferon (if). to measure the response, a system developed to study human nasal epithelial cells in vitro was used. nasal epithelial cells responded equally to both leukocyte and fibroblast if, with development of resistance to virus replication that was time and dose dependent. cells required contact with 1,000 u of if (400 69/19 reference units) for 4 h to produce consistently a significant reduct ... | 1977 | 193789 |
| affinity of sendai virus for the inner ear of mice. | the direct immunofluorescent antibody method revealed that sendai virus, which was thought to be most prevalent in respiratory diseases in mice, infected the inner ear of mice when the virus was injected intracerebrally. specific immunofluorescence that indicated the presence of antigens of sendai virus was observed in both perilymphatic and endolymphatic structures. the routes of virus spread are discussed. this experimental study, using newborn mice and sendai virus, may be useful for the inve ... | 1977 | 193797 |
| histopathological changes in mice treated with extracts of the histamine-sensitizing factor of bordetella pertussis. | the histamine-sensitizing factor (hsf) of bordetella pertussis was isolated in a highly purified form. in addition to inducing profound sensitization to histamine, it also caused a significant lymphocytosis and produced an enhancement of reaginic antibody production in animals upon immunization with antigen. biologically active doses of hsf produced significant pathological changes in mice including congestion and edema of the lung and a marked depletion of cells in the thymus, white pulp of the ... | 1977 | 193800 |
| effects of chaotropic agents versus detergents on dihydroorotate dehydrogenase. | as chaotropic salts are generally believed to affect water structure in a manner which increases lipophilicity of water, they may seem to be capable of substituting for detergents in the solubilization of particulate enzyme. although solubilization either by detergents or by chaotropic salts has been demonstrated with several membrane proteins, the effects these agents have on the properties and activity of an enzyme may be quite different. this is illustrated by the effects on mammalian mitocho ... | 1977 | 193834 |
| the storage lipids in tangier disease. a physical chemical study. | the physical states and phase behavior of the lipids of the spleen, liver, and splenic artery from a 38-yr-old man with tangier disease were studied. many intracellular lipid droplets in the smectic liquid crystalline state were identified by polarizing microscopy in macrophages in both the spleen and liver, but not in the splenic artery. the droplets within individual cells melted sharply over a narrow temperature range, indicating a uniform lipid composition of the droplets of each cell. howev ... | 1977 | 193870 |
| splenic influence of t cell function: the immunobiology of the inbred hereditarily asplenic mouse. | | 1977 | 194980 |
| [studies on the antimicrobial effect of vitamin d (author's transl)]. | in in vitro studies vitamin d3 proved inhibitory on strains of staphylococcus aureus, streptococcus pyogenes, klebsiella pneumoniae. escherichia coli, and candida albicans. in the presence of 5x10(4)-9x10(4) iu/ml vitamin d3 the organisms were killed or reacted with a marked growth inhibition. | 1977 | 195120 |
| [acupuncture for pains of the face and the head is there any reasonable application? (author's transl)]. | the physiological bases of the treatment with acupuncture as well as its practical application in pain therapy were discussed at the meeting of the orl-society of munich on the 4th december, 1976. | 1977 | 195167 |
| radiation effects on testes. xi. studies on glycogen and its metabolizing enzymes following radiation-induced atrophy. | | 1977 | 195299 |
| bacteriology of the human biliary tract and the duodenum. | using the modern anaerobic transport media and meticulous culture techniques, 74 patients undergoing biliary tract surgery were studied. the biliary system was found to be sterile in 58 patients (78%). fifteen patients had 35 isolates of aerobic and facultative bacteria. the most common ones were klebsiella, enterococcus, and escherichia coli. the only anaerobe isolated was clostridium perfringens. eight of 17 patients (47%) with acute cholecystitis and five of 49 patients (10%) with chronic cho ... | 1977 | 195558 |
| the effects of l9394 on adrenergic transmission in the cat spleen [proceedings]. | | 1977 | 195662 |
| enzymes of the purine ribonucleotide cycle in rat hepatomas and kidney tumors. | | 1977 | 195718 |
| a comparative ultrastructural and biochemical study between the effects of chlorphentermine and phentermine on rat lung. | | 1977 | 195833 |
| retention deficit for avoidance training in hypophysectomized rats: time-dependent enhancement of retention performance with post-training acth injections. | | 1977 | 195888 |
| [serum lipids in experimental atherosclerosis in guinea pigs treated with protein hydrolysate]. | the authors carried out studies on 223 male guinea pigs, weighting from 350 to 500 gm, fed with a diet containing 0,3% of cholesterol, disolved in cow butter. a part of the animals were injected with protein hydrolysate every other day for a period of 140 days. the level of serum lipids-total cholesterol, beta-lipoproteins, phospholipids and total lipids was examined. they found significantly higher values in the animals, receiving cholesterol in comparison with the control animals-292.4:84.9; 1 ... | 1977 | 196824 |
| [specific endonuclease of klebsiella pneumoniae oks]. | | 1977 | 199404 |
| isolation of the major glycoprotein (gp 70) of simian sarcoma virus (ssv-1/ssav-1) in preparative quantities. | | 1977 | 201120 |
| [the influence of dietary protein quality on the activities of several metallo-enzymes]. | | 1977 | 201126 |
| electron microscopic studies on the effect of acth and flavin adenine dinucleotide on adrenocortical atrophy of hypophysectomized rat. | electron microscopic observation was made on the outer fasciculata cells in the adrenal cortex of hypophysectomized rats receiving 10 mg of fad and/or 0.3 mg of acth intraperitoneally once a day for 5 consecutive days from 24 hours after hypophysectomy. the simultaneous administration of fad and acth to the hypophysectomized rat was more effective for preventing adrenocortical atrophy induced than the administration of acth alone. this effect appeared as clear cells with low electron density. wh ... | 1977 | 201150 |
| epstein-barr virus and cytomegalovirus antibodies in infectious mononucleosis. | a method has been evolved for the demonstration of epstein-barr virus (ebv) and cytomegalovirus (cmv) infection in 83 cases of infectious mononucleosis. serum samples were tested for ebv igm, anti-vca igg, anti-ebna, cmv igm and cmv igg antibodies. an acute-phase sample (or samples) and a convalescence sample were examined in each case, and in 44 cases an additional samples was examined 5-12 months after the illness. since the different antibodies showed characteristic differences in both titre ... | 1977 | 201153 |
| the role and control of brain 5-hydroxytryptamine. | | 1977 | 201156 |
| polymyxin b and rifampin: new regimen for multiresistant serratia marcescens infections. | polymyxin b and rifampin were given to 12 patients with multi-drug-resistant nosocomial serratia marcescens infections. eight cures were achieved; drug hepatotoxicity occurred once; one fatal suprainfection was encountered; and two patients died during therapy of causes related to severe underlying illnesses. polymyxin b and rifampin were uniformly synergistic in vitro against the infecting strains and against 40 additional clinical isolates of s. marcescens. | 1977 | 201214 |
| emc viral infection of the coronary blood vessels in newborn mice: viral vasculitis. | the coronary arteries, veins and capillaries of newborn mice experimentally infected with encephalomyocarditis (emc) virus were studied histologically and electronmicroscopically. damage to these coronary vessels was patchy. some lesions were extensive, particularly when adjacent to areas of myocardial damage. the histological findings consisted of swelling of adventitial and endothelial cells pyknosis, and polymorphonuclear leucocyte and round cell infiltration. histological and ultrastructural ... | 1977 | 201264 |
| comparison of the binding characteristics of bovine thyrotropin and human chorionic gonadotropin to thyroid plasma membranes. | | 1977 | 201451 |
| effect of combined dopaminergic and gaba-ergic stimulation on ouabain-induced epileptiform activity. | in this study we tested a hypothesis that dopamine and gaba receptor-stimulating agents given together might mutually potentiate their anticonvulsant activities. to test this hypothesis, experiments were performed on free-moving rabbits with epileptiform activity evoked by cortical application of ouabain. after combined treatment with apomorphine and ghba 3 out of 6 animals displayed no eeg epileptiform activity, and in the remaining 3 rabbits this activity was greatly reduced. a combined pretre ... | 1977 | 201458 |
| [enzymes of the pentose phosphate pathway in the brains of rats during long-term deprivation of the paradoxical stage of sleep]. | the selective paradoxical sleep (ps) deprivation in rats entailed during first 2 days a drop in activity of glucose-6-phosphatehydrogenase by 80 and 60%, and of 6-phosphogluconatdehydrogenase -- by 20--35 and 40--50% in the brain-stem and the cortex, respectively. activity of the transketolase decreased by 27--29% on the 2nd day of ps deprivation only. on the 4th day, normalizing of activity of all the enzymes under study except transketolase, was observed in both regions of the brain. the consu ... | 1977 | 201508 |
| characteristics of energy metabolism in specialized muscle of bovine heart. | characterization of the energy metabolism pattern of the specialized heart muscle of bovine heart was studied in comparison with that of the ordinary heart muscle. mitochondrial oxygen consumption of the specialized heart muscle was significantly lower than that of the ordinary heart muscle with succinate as the substrate. on the other hand, there was no significant difference in oxygen consumption between both heart muscles with glutamate + malate as the substrates. the activity levels of succi ... | 1976 | 201990 |
| relationship between the reduction of oxygen, artificial acceptors and cytochrome p-450 by nadph--cytochrome c reductase. | the interaction of nadph--cytochrome c reductase with oxygen, artificial acceptors and cytochrome p-450 was studied. the generation of superoxide anion radicals (o2-.) from the oxidation of adrenaline to adrenochrome catalysed by nadph--cytochrome c reductase proceeds independently of the interaction of the enzyme with the artificial anaerobic acceptors cytochrome c or 2,6-dichlorophenol-indophenol. propyl 3,4,5-trihydroxybenzoate inhibited competitively the adrenaline oxidation by isolated nadp ... | 1977 | 202259 |
| appearance of early and late components of epstein-barr virus-associated membrane antigen in daudi cells superinfected with p3hr-1 virus. | this study investigated the synthesis of membrane antigen (ma) as well as virus capsid antigen (vca) and early antigen (ea) in daudi cells which had been superinfected with the p3hr-1 strain of epstein-barr virus (ebv) and then treated with trypsin to remove initially absorbed ma-positive material from the cell surface. synthesis of ma, vca and ea was completely inhibited by puromycin. a marked reduction in the frequency of ma positive cells was observed in superinfected cells cultured in the pr ... | 1978 | 202665 |
| [mechanism of action of cyclic amp-dependent histone kinase. substrate specificity of the catalytic enzyme unit]. | interaction of several nucleotide derivates with homogenous catalytic subunit of cyclo-amp-dependent histone kinase from pig brain is studied. inhibition constants of these compounds are calculated, and the affinity of inhibitors to the enzyme active site is evaluated. the nature of heterocyclic base is found to be the main contribution into binding with substrate. the enzyme specificity with respect to a number of bivalent metal ions is studied, and mg2+ is demonstrated to be the only efficient ... | 1978 | 203340 |
| nucleotide sequence of the dna replication origin for human papovavirus bkv: sequence and structural homology with sv40. | dna and rna sequencing techniques were used to obtain the sequence surrounding the origin of dna replication for human papovavirus bkv. the structure is characterized by a true palindrome of 17 residues followed by two sets of symmetrical sequences and a stretch of 20 at residues. within the two symmetrical sequences is a segment containing a strong purine bias, 23 of 26 nucleotides. these structures are similar, if not identical, to those found in the region of the sv40 replication, origin. wit ... | 1978 | 203403 |
| histochemical distribution of phosphatases in different regions of the epididymis of the adult rhesus monkey macaca mulatta. | | 1977 | 203524 |
| varicella-zoster virus vaccine. | | 1978 | 203727 |
| [two outbreaks of "clostridium perfringens" food poisoning: epidemiological remarks (author's transl)]. | two outbreaks of cl. perfringens food poisoning which occurred in florence during 1976 have been described. the first one involved three hundred primary school children; processed re-heated turkey meat was thought to have been the vehicle of infection in the school meal. the clinical symptoms consisted of mild diarrhoea in all cases and the duration of the illness was about 12 hours. the possible part played by food storage temperature, post-cooking periods and food trolleys in the spread of inf ... | 1977 | 204262 |
| oxidation of protein sulfhydryls by products of peroxidase-catalyzed oxidation of thiocyanate ion. | | 1978 | 204336 |
| arenaviruses in perspective. | | 1978 | 204386 |
| comparative studies on nuclear and cytosol phosphohistone phosphatases of calf liver. | | 1978 | 204526 |
| non-hodgkin lymphomas: cell populations and functional behavior. | | 1977 | 204551 |
| properties of epstein-barr virus transformed woolly monkey lymphoblastoid cell lines. | | 1978 | 204945 |
| the synthesis and secretion of serum albumin in morris hepatomas 5123tc and 9121. | in vivo, morris hepatomas 5123tc and 9121 do not secrete serum proteins into the bloodstream. however, they synthesize albumin, at a reduced rate, if compared with liver. the produced albumin accumulates, leading to an enlargement of the golgi apparatus and the appearance of intracellular vesicles. the proportion and the absolute amount of albumin found within the hepatoma cells is increased compared with liver. as described recently for liver in vivo and for hepatocyte suspensions, albumin is s ... | 1977 | 205109 |
| a comparative spectroscopic study of two non-haem iron proteins lacking labile sulphide from desulphovibrio gigas. | the ultraviolet visible, and near infrared spectrum of a two-iron protein from desulphovibrio gigas, a new type of non-haem iron protein lacking labile sulphide, is compared with that of d. gigas rubredoxin. the charge transfer band maxima of rubredoxin at 495 and 565 nm are less separated in the new protein implying a higher symmetry of the two iron centres. the existence of a spin-spin interaction between the two iron centres in the new protein is suggested by the magnetic susceptibility measu ... | 1978 | 205263 |
| arginine metabolism in saccharomyces cerevisiae: subcellular localization of the enzymes. | subcellular localization of enzymes of arginine metabolism in saccharomyces cerevisiae was studied by partial fractionation and stepwise homogenization of spheroplast lysates. these enzymes could clearly be divided into two groups. the first group comprised the five enzymes of the acetylated compound cycle, i.e., acetylglutamate synthase, acetylglutamate kinase, acetylglutamyl-phosphate reductase, acetylornithine aminotransferase, and acetylornithine-glutamate acetyltransferase. these enzymes we ... | 1978 | 205532 |
| study of microsomal mixed function oxidative demethylation and deformylation of 4-methyl and 4-hydroxymethylene sterols. | | 1978 | 205540 |
| insulin receptors are widely distributed in the central nervous system of the rat. | | 1978 | 205798 |
| mechanistic studies of polyene enhancement of interferon production by polyriboinosinic-polyribocytidylic acid. | the production of interferon by polyriboinosinic-polyribocytidylic acid [poly(i) . poly(c)] and poly(i) . poly(c)-diethylaminoethyl-dextran in l929 cells was enhanced from 10 to 100 times by polyene macrolides, including amphotericin b (amb), amb methyl ester, nystatin, and filipin. amb and its water-soluble methyl ester were the most effective; retinol, a nonmacrolide polyene, was ineffective. interferon induction by newcastle disease virus was not enhanced by amb. the kinetics of interferon pr ... | 1978 | 206199 |
| subcellular distribution of enzymes involved in alpha-glucan utilization in klebsiella pneumoniae. proteins of cytopasm, periplasm, cytoplasmic and outer membrane. | | 1978 | 206221 |
| response to several avian respiratory viruses as affected by infectious bursal disease virus. | after being inoculated with the infectious bursal disease virus (ibdv) at one day of age, specific-pathogen-free chickens were inoculated with either newcastle disease virus (ndv), infectious bronchitis virus (ibv), or infectious laryngotracheitis virus (iltv). their immunity was challenged 2-3 weeks later with homologous virus, and antibody titers were determined for iltv and ibv. several studies were made to determine the effects of ibdv on the development of persistent or chronic virus infect ... | 1978 | 206256 |
| [recent developments in the physiology of the exocrine pancreas]. | | 1977 | 206300 |
| effects of prostaglandin e2 and a prostaglandin endoperoxide analogue on neuroeffector transmission in the rat anococcygeus msucle. | 1 investigations were made into the effects of prostaglandin e(2) (pge(2)) and a prostaglandin endoperoxide analogue (upjohn compound u-46619) on the responses of the rat anococcygeus muscle to field stimulation of the intrinsic sympathetic nerves, and to exogenous noradrenaline. the effects of pge(2) on responses to stimulation of intrinsic inhibitory nerves were also studied.2 pge(2) (5.6 x 10(-8) or 2.8 x 10(-6) mol/l) decreased motor (sympathetic) responses to field stimulation at all freque ... | 1978 | 206303 |
| thiazide diuretics do not potentiate camp response to parathyroid hormone. | we evaluated the hypothesis that thiazide-induced hypercalcemia reflects potentiation of the camp response to parathyroid hormone (pth) consequent to inhibition of phosphodiesterase in bone and kidney. a panel of thiazide diuretics did inhibit low-km phosphodiesterase activity from bone homogenates. however, furosemide, a nonthiazide diuretic that does not promote calcium retention, was more potent a phosphodiesterase inhibitor than either chloro- or hydrochlorothiazide (ctz, hctz). thiazides di ... | 1978 | 206800 |
| [polyphosphoinositides and their functions in biological membranes]. | | 1978 | 207036 |
| [intrinsic protein phosphorylation in the mitochondrial membranes of a calf brain (author's transl)]. | | 1976 | 207233 |
| camp-phosphodiesterase inhibitors and tracheal smooth muscle relaxation. | | 1978 | 207279 |
| plasma membrane cyclic amp-dependent protein phosphorylation system in l6 myoblasts. | plasma membranes can be isolated without disruption of cells by the plasma membrane vesiculation technique (scott, r.e. (1976) science 194, 743-745). a major advantage of this technique is that it avoids contamination of plasma membranes with intracellular membrane components. using this method, we prepared plasma membranes from l6 myoblasts grown in tissue culture and studied the characteristics of the protein phosphorylation system. we found that these plasma membrane preparations contain prot ... | 1978 | 207325 |
| [study of insulin receptors on liver and hepatoma cell plasma membranes]. | plasma membranes (pm) of helathy rats as well as those hepatomas and pm of tumor-bearing rats were found (radioreceptor assay) to have apparently two groups of receptors for insulin with a high and low affinity for the hormone respectively and different insulin-binding capacities. kass values of the receptors with a high affinity for insulin are drastically decreased in the pm of ascites zajdela hepatoma (azh) and of solid hepatoma 27 (sh-27) as well as in the liver of sh-27-bearing animals, but ... | 1978 | 207360 |
| a hundred years of the hepatotrophic controversy. | venous blood returning from the splanchnic viscera has liver-supporting (hepatotrophic) qualities not found to the same degree in other kinds of arterial or venous blood. the effects of portal blood have been noted in animals with two livers (or a differential portal blood supply to different regions of one liver) to include hypertrophy, glycogen storage, hyperplasia, capacity for regeneration, increase of several synthetic functions, and maintenance of normal structure. the main splanchnic veno ... | 1977 | 207494 |
| electron paramagnetic resonance studies on membrane-bound respiratory nitrate reductase of klebsiella aerogenes. | | 1978 | 207577 |
| the isolation and characterization of the vitamin d-binding protein from rat serum. | | 1978 | 207701 |
| alkaline dnase activity in cells infected with a temperature-sensitive mutant of herpes simplex virus type 2. | bhk cells infected with the temperature-sensitive mutant ts13 of herpes simplex virus type 2 at a nonpermissive temperature lack the alkaline nuclease activity, which is induced by the mutant at a permissive temperature and by wild-type virus at either temperature. for ts13, enzyme activity could be induced by a temperature shift to permissive conditions, but not in the presence of cycloheximide. after a shift from permissive to nonpermissive conditions in the presence of cycloheximide, the acti ... | 1978 | 207883 |
| intramembrane changes occurring during maturation of herpes simplex virus type 1: freeze-fracture study. | during the maturation of two strains of herpes simplex virus type 1 (vr3 and patton), intramembrane changes were detected with the freeze-fracture technique in the viral envelope and the infected cell plasma membrane, and these changes were compared with data obtained from thin sections. regardless of the strain, the inner leaflet of the viral envelope of extracellular virions was characterized by a density of intramembrane particles (imp) three times larger than the host nuclear and plasma memb ... | 1978 | 207896 |
| adenovirus-induced inhibition of cellular dnase. | during the productive infection of kb cells by adenovirus type 5 (ad5), there is a progressive decrease in the level of cellular dnase activity towards single-stranded dna, in contrast to dna polymerase which remains relatively constant throughout the infection. this decrease is prevented by the inhibition of protein synthesis by cycloheximide. the inhibition of dnase activity does not occur after infection by ad5 ts125, a dna-negative mutant which fails to induce the adenovirus-specific dna bin ... | 1978 | 207901 |
| tumor imaging with x-rays using macrophage uptake of radiopaque fluorocarbon emulsions. | radiopaque fluorocarbon (rfc) emulsions were prepared with small particle size and high concentration of the fluorocarbon. when rfc emulsions were injected intravenously in hamsters, rats, and mice with eight types of malignant tumors, the tumors became radiopaque, except in the mice with spontaneous teratoma of the ovaries. tumors as small as 3 to 4 mm could be defined radiographically using routine x-ray techniques. the tumors remained radiopaque for days to weeks after injection. light and el ... | 1978 | 208188 |
| influence of preincubation on the development of the inhibition of protein synthesis in extracts from interferon-treated mouse l cells. action on trna. | | 1978 | 208258 |
| purification of four pyruvate kinase isozymes of rats by affinity elution chromatography. | 1. purification of four isozymes of pyruvate kinase (atp:pyruvate 2-o-phosphotransferase, ec 2.7.1.40) l, m1, m2 and r was much improved to give good yields by affinity elution chromatography. the enzyme was eluted from a phosphocellulose column with 0.5 mm phosphoenolpyruvate. types l, m2 and r were stabilized with fructose 1,6-diphosphate throughout the purification procedures. 2. the isozymes were crystallized under various conditions: types l and r were readily crystallized from medium of lo ... | 1978 | 208618 |
| [specific role of sex steroids on the pituitary level. sex steroids and anterior pituitary secretion]. | although sex steroids were known to play a role in the control of lh, fsh, tsh and prolactin secretion, in vivo experiments could not discriminate between hypothalamic and pituitary sites of action. in this study, the specific action of sex steroids at the anterior pituitary level could be achieved using rat adenohypophyseal cells in primary culture. while estrogens stimulated the sensitivity of the lh and fsh responses to lhrh, androgens had differential effects on the secretion of the two gona ... | 1978 | 208692 |
| measurement of cytochrome oxidase activity by kinetic microdensitometry using substrate gel films [proceedings]. | | 1978 | 208706 |
| isolation of function human trophoblast cells and their partial characterization in primary cell culture. | human trophoblast isolation and cell culture procedures were examined to identify variables that enhance secretion of chorionic gonadotropin (hcg) in primary culture. brief exposure of unminced first-trimester placental specimens to a solution of trypsin-edta-dnase, and isolation of the dispersed cells after ficoll-hypaque centrifugation yielded primary cultures that were high in hcg secretion and content of epithelial-like cells. the gradual decline in hcg level with time in monolayer culture i ... | 1978 | 208965 |
| neoplastic transformation of hamster brain cells in vitro by polyoma virus. | the transformation of cultivated hamster brain cells by polyoma virus is reported. the transformed cell line contained polyoma virus-specific nuclear, surface and transplantation antigens. subcutaneous and intracranial inoculations revealed high tumorigenicity of the cells. brain-specific s 100 protein was found in these tumors with immuno-peroxidase staining, suggesting that they were of a nervous nature. both in vivo and in vitro, the cells had glial features as studied by phase contrast, ligh ... | 1978 | 208986 |
| [the appearance of pathognostic inclusion bodies in verruca vulgaris (author's transl)]. | pathognostic inclusion bodies develop in the nucleus. they frequently occur in the upper layers of the pathologically changed stratum spinosum. they are stained in an amphophilic or basophilic manner. their structure is a nearly homogenous, finely grained or plaquelike one. the inclusion bodies contain masses of human wart viruses in a cristalline-like arrangement or are irregularily distributed. feulgen staining is positive. different pictures of inclusion bodies are demonstrated in paraffin se ... | 1978 | 209643 |
| epidemiological aspects of rotavirus infection in hospitalized venezuelan children with gastroenteritis. | the prevalence of rotavirus infection in hospitalized venezuelan children with gastroenteritis was studied during the period november 1975 to december 1976. rotaviruses were the pathogens most frequently associated with gastroenteritis, being found in 121 of 293 (41.3%) patients and in only 3 of 66 (4.5%) controls. other viruses (adenoviruses, enteroviruses, and small icosahedrical viruses) were detected at a lower frequency both in cases and controls. rotaviruses were detected at a lower freque ... | 1978 | 209696 |
| metabolic activation and hepatotoxicity. toxicity of bromobenzene in hepatocytes isolated from phenobarbital-and diethylmaleate-treated rats. | | 1978 | 209739 |
| studies on the metabolism of the lipoprotein lp (a) in man. | lp(a) was isolated and labeled by reductive alkylation. radioactivity only entered the protein moiety of the lipoprotein. no change in the immunological or physicochemical properties of lp(a) was noted after the radiomethylation. after incubation of labeled lp(a) with whole serum for 24 h in vitro, more than 99% of the radioactivity of the incubated sample was found in lp(a). in 4 subjects lp(a) was injected intravenously. a linear decline of the specific activity of lp(a) in the serum was found ... | 1978 | 209797 |
| firing rates and patterns of output and nonoutput cells in cortical areas 5 and 7 of cat during the sleep-waking cycle. | | 1978 | 210033 |
| coenzyme b12-dependent diol dehydratase: regulation of apoenzyme synthesis in klebsiella pneumoniae (aerobacter aerogenes) atcc 8724. | immunochemical studies demonstrated that klebsiella pneumoniae (aerobacter aerogenes) atcc 8724 produces only a single diol dehydratase whether grown on glycerol or on 1,2-propanediol. the enzyme was subject to induction by 1,2-diols and to catabolite repression reversed by cyclic amp. | 1978 | 210157 |
| measuring interhemispheric transfer time in man. | | 1977 | 210552 |
| [interferonogenic and antiviral activity of the double-stranded replicative form of phage f2 rna in tissue culture and on animals]. | biological activity of a new natural interferon inductor, the replicative rna form of phage f2 (rff2) was studied. a possibility of using rff2 for production of highly active interferon under conditions of superinduction providing an increase in the interferon yield by to 256--512 times as compared to the control samples was shown. the protective interferonogenic and antiviral effect of rff2 in mice infected with semliki forest virus (sfv) and tickborne encephalitis virus (tbev) was studied on a ... | 1978 | 210710 |
| electron-paramagnetic-resonance studies on nitrogenase of klebsiella pneumoniae. evidence for acetylene- and ethylene-nitrogenase transient complexes. | klebsiella pneumoniae nitrogenase exhibited four new electron-paramagnetic-resonance signals during turnover at 10 degrees c, ph7.4, which were assigned to intermediates present in low concentrations in the steady state. 57fe-substituted mo--fe protein showed that they arose from fe--s clusters in the mo--fe protein of nitrogenase. the new signals are designated: ic, g values at 4.67, 3.37 and approx. 2.0; vi, g values at 2.125, 2.000 and 2.000; vii, g values at 5.7 and 5.4; viii, g values at 2. ... | 1978 | 210766 |
| localization of central noradrenergic mechanisms in cardiovascular regulation in rats. | 1. various drugs were injected stereotactically into the brain of anaesthetized rats. 2. noradrenaline injected into the area of the nucleus of the tractus solitarius in the lower brain stem or into the far anterior hypothalamus/pre-optic region induced a fall in blood pressure and heart rate related to the administered dose. 3. when injected into the anterior hypothalamus/pre-optic region, clonidine and alpha-methylnoradrenaline induced a long-lasting decrease in blood pressure and heart rate. | 1975 | 210991 |
| the spin-state transition of the hemochrome non-equilibrium conformation in partially reduced human methemoglobin. a pulse-radiolysis study of aqueous-methanol solutions of methemoglobin. | the effect of external parameters on the relaxation process of the hemochrome-type non-equilibrium conformation in partially reduced methemoglobin has been investigated. the relaxation of the intermediate ferrous low-spin state to the high-spin equilibrium conformation of hemoglobin appears to be facilitated particularly by protons and phosphate ions. in addition to studying the spin-state transition in aquomethemoglobin we have also studied it in complexes of the heme group in methemoglobin wit ... | 1978 | 211030 |
| effect of n-(3,5-dichlorophenyl)succinimide on the histological pattern and incidence of kidney tumors induced by streptozotocin rats. | the effect of the nephrotoxic substance, n-(3,5-dichlorophenyl)succinimide, on the histological pattern and incidence of kidney tumors induced by streptozotocin in rats was studied. in groups administered streptozotocin alone or in combination with nicotinamide, the histological pattern and the incidence of kidney tumors in rats were similar; renal cell tumors developed in 1 of 9 rats (11.1%) and in 2 of 17 rats (11.8%), respectively. however, post-treatment with n-(3,5-dichlorophenyl)succinimid ... | 1977 | 211064 |
| catalase positive particles from pig lung. biochemical preparations and morphological studies. | in pig lung tissue catalase positive particles (cps) are abundant especially in type ii pneumocytes and in clara cells. in both cell types they occur as circular, oval or elongated membrane profiles surrounding a moderately electron dense matrix lacking a crystalline core. in clara cells and in part of type ii pneumocytes they are located as individual particles without any evident morphological relation to other cell organelles. in part of type ii pneumocytes 5-8 particles are forming a group a ... | 1978 | 211101 |
| palmitylcarnitine inhibition of the calcium pump in cardiac sarcoplasmic reticulum: a possible role in myocardial ischemia. | | 1978 | 211361 |
| the effect of drugs which alter gaba-ergic function on cerebellar guanosine-3',5'-monophosphate content. | | 1978 | 211362 |
| [functioning tumors with special reference to ectopic hormone producing tumors (author's transl)]. | | 1978 | 211547 |
| [virological and pathological long term observation of pancreatitis in mice infected with coxsackie virus b3 (author's transl)]. | | 1978 | 211725 |
| [vaccine from cellular fragments of b. pertussis. ii. toxic properties of the vaccine]. | | 1978 | 211762 |
| discharge of efferent vagal fibers supplying gastric antrum: indirect study by nerve suture technique. | | 1978 | 211860 |
| adrenocorticotropin and plasma aldosterone concentration and deoxycorticosterone in man. | | 1977 | 211909 |
| the neural regulation of compensatory adrenal growth. | | 1977 | 211910 |
| [activity of the alternative complement pathway by various axenic strains of entamoeba histolytica]. | the activation of the alternative pathway of complement by axenic cultures of e. histolytica is reported. the activation is carried out in different proportions by several axenic strains, i.e., hk9:nih, hm1:imss, hm2:imss and hm3:imss; the end result consists of a destruction of the parasite as well as consumption of the serum complement. the participation of the alternative pathway was studied in the presence of egta and mg++, zymosan, heat-inactivation at 50 degree c for 20 min and immunoelect ... | 1978 | 211963 |
| [transmissible gastroenteritis of swine as a model for infectious diarrhea]. | transmissible gastro-enteritis is a virus-caused diarrhoeal disease of swine which may result in up to a total loss among newborn animals. changes are, primarily, of pathologicoanatomic nature and take place in the small intestine. the epithelium of the intestinal villi is completely destroyed, and diarrhoea is the result. deformation in blood composition is a secondary sequel. the diarrhoea proper causes dehydration and acidosis which, in conjunction with abnormal heart function due to hyperkal ... | 1978 | 211981 |
| cholinergic stimulation of polyphosphoinositide metabolism in brain in vivo. | | 1978 | 212082 |
| genetic determination of the alpha-galactosidase developmental program in mice. | the expression of alpha-galactosidase in liver, heart, and brain during postembryonic development has been examined in several inbred mouse strains. in most strains, the developmental patterns of alpha-galactosidase are coordinate with those of two other acid hydrolases, beta-glucuronidase and beta-galactosidase. certain inbred mouse strains, including members of the c57-c58 family, have a tissue-specific alteration in the temporal expression of alpha-galactosidase activity. this alteration show ... | 1975 | 212204 |
| experimental evolution in bacteria. | | 1978 | 212253 |