Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| ceftriaxone: a beta-lactamase-stable, broad-spectrum cephalosporin with an extended half-life. | ceftriaxone is an aminothiazolyl-oxyimino cephalosporin. it possesses the typical in vitro activity of a third-generation cephalosporin with excellent activity against many gram-negative aerobic bacilli: escherichia coli; species of proteus, klebsiella, morganella, providencia and citrobacter; and enterobacter agglomerans. ceftriaxone also has outstanding bactericidal action against pneumococci, group b streptococci, meningococci, gonococci and hemophilus influenzae. in healthy volunteers, it ha ... | 1985 | 3906584 |
| contribution of beta-lactamases to bacterial resistance and mechanisms to inhibit beta-lactamases. | resistance of bacteria to beta-lactam antibiotics has become a serious problem in the past several decades. virtually all staphylococcus aureus, and many hemophilus influenzae, branhamella catarrhalis, neisseria gonorrhoeae, enterobacteriaceae, and bacteroides species possess beta-lactamases that hydrolyze penicillins and cephalosporins. the most common plasmid-mediated beta-lactamase is the tem enzyme (richmond-sykes type iiia), which is present in hemophilus, neisseria, and enterobacteriaceae. ... | 1985 | 3907341 |
| [biochemical properties of enterobacteria on polystyrene plates]. | the authors studied 84 strains of enterobacteria. the reliability of the results of the biochemical testing obtained by the micromethod with the use of polystyrene plates was examined comparatively to the data obtained by the classical method and api microsystems manufactured in france. of the 84 strains of enterobacteria, 36 belonged to proteus, 24 to enterobacter, 8 to klebsiella, 5 to citrobacter, and 11 to e. coli. of the strains tested, 50 were isolated from the intestine of children and ad ... | 1985 | 3909634 |
| cefamandole resistance transfer in bacterial strains from two newborn units. | transfer of cefamandole resistance was demonstrated from strains of citrobacter freundii as well as from individual strains of enterobacter cloacae, acinetobacter anitratus and klebsiella pneumoniae isolated from patients in two newborn units. in citrobacter freundii, cefamandole resistance was transferred always with cephalotin resistance as well as with a tem-like beta lactamase (conferring resistance to ampicillin, carbenicillin and azlocillin). citrobacter freundii strains from hospital i we ... | 1985 | 3910723 |
| [hr 810 (cefpirome). experimental evaluation of the in vitro and in vivo antibiotic activity of a new amino-2-thiazole methoxy- imino cephalosporin]. | hr 810 or cefpirome is a new amino thiazole cephalosporin whose specific characteristic is a cyclopentenopyridinium group in position 3 of the cephem nucleus. this structure is responsible for a broad spectrum of activity, covering enterobacteriaceae, including cephalosporinase-producing enterobacter spp. and citrobacter spp., staphylococcus aureus, pseudomonas aeruginosa and group d streptococci. | 1985 | 3937124 |
| rapid identification of escherichia coli from routine urine specimens based on macroscopic criteria. | in our laboratory, selected strains of gram-negative rods from urine samples are identified as escherichia coli on the basis of smell and morphology on lactose agar. to investigate the accuracy of this routine practice, 211 consecutive strains were tested in the urea-indole tube of the three-tube method (3-tm), in the pgua test detecting beta-glucuronidase activity and in the simmons' citrate test, to select the strains that were non-e. coli. additional 1022 strains were tested by the indole and ... | 1985 | 3914821 |
| studies on specificity of protection induced by immunization with outer membrane proteins of shigella. | immunization of c3h/hej mice with outer membrane proteins (omp) and with peptidoglycan associated proteins (pgp) isolated from shigella flexneri 3a and from shigella sonnei phase i protected the animals against lethal dose of homologous and heterologous bacteria and against various serotypes of shigella flexneri. neither of the protein preparations protected the animals against challenge with escherichia, klebsiella, citrobacter, salmonella, serratia, proteus and pseudomonas. omp preparations ho ... | 1985 | 3914866 |
| the in vitro activity and beta-lactamase stability of cefpirome (hr 810), a pyridine cephalosporin agent active against staphylococci, enterobacteriaceae and pseudomonas aeruginosa. | the in vitro activity of cefpirome, a new cyclopyridinium cephalosporin, was evaluated against 947 aerobic and anaerobic bacteria. cefpirome inhibited 90% of escherichia coli, klebsiella spp., citrobacter diversus, morganella morganii, proteus vulgaris, proteus mirabilis, aeromonas spp., salmonella spp., shigella spp. and haemophilus and neisseria species at less than or equal to 0.4 mg/l. it had activity comparable to that of cefotaxime, ceftizoxime, ceftazidime, aztreonam, and moxalactam again ... | 1985 | 3928497 |
| [activity of the amoxicillin-clavulanic acid (augmentin) combination on strains of hospital isolates]. | all strains of staphylococcus aureus and gram negative bacilli (enterobacteriaceae, pseudomonas aeruginosa, acinetobacter) isolated from 01.01 to 03.31.83 were studied using agar diffusion with augmentin-impregnated discs (amoxicillin 20 micrograms + clavulanic acid 10 micrograms). augmentin is active against penicillinase-producing staphylococci susceptible to methicillin, whereas methicillin-resistant strains are also resistant to augmentin. according to the susceptibility of strains to amoxic ... | 1985 | 3929215 |
| mechanisms and clinical relevance of antagonism between beta-lactam antibiotics. | the author discussed the problem of antagonism between combined antibiotics. several examples of antagonistic combinations between cefoxitin plus moxalactam, or carbenicillin were cited in the literature. this phenomenon may occur especially with enterobacter spp., pseudomonas aeruginosa, citrobacter spp. and serratia marcescens: in these species induction of chromosomally mediated beta-lactamase by certain potent inducers such as cefoxitin has been suggested as the main mechanism of antagonism. ... | 1985 | 3872724 |
| a perspective on the present contribution of beta-lactamases to bacterial resistance with particular reference to induction of beta-lactamase and its clinical significance. | resistance of bacteria to beta-lactam antibiotics has become a serious problem in the past several decades. virtually all staphylococcus aureus, many haemophilus influenzae, branhamella catarrhalis, neisseria gonorrhoeae, many enterobacteriaceae, many pseudomonas aeruginosa and bacteroides species possess beta-lactamases which hydrolyze to varying degree penems, penams, carbapenems, cephems, cephamycins and monobactams. the most common plasmid-mediated beta-lactamase is the so-called tem beta-la ... | 1985 | 3872725 |
| [cefminox concentration in tissues and clinical efficacy of cefminox in acute peritonitis]. | cefminox sodium (cmnx, mt-141), a new semisynthetic cephamycin, having marked resistance to beta-lactamase, and a broad spectrum of antibacterial activity against various bacterial species, including haemophilus influenzae, serratia marcescens and citrobacter freundii, cmnx has higher activity in vivo than in vitro. for therapeutic purpose, cmnx was given in a daily dose of 0.5 g (0.5 g x 1) to 2 g (1 x 2) by intravenous drip infusion for 4 to 8 days to 24 cases with acute peritonitis (17 cases ... | 1985 | 3930784 |
| [gram-negative bacteria resistant to antibiotics in foods]. | from 154 food samples, including vegetables (lettuce), milk and meals served at school it was possible to isolate and identify 400 gram negative bacilli distributed among 339 enteric bacteria (escherichia, shigella, citrobacter, klebsiella, enterobacter, serratia and proteus) and other 61 non enteric bacilli (acinetobacter, flavobacterium, aeromonas and pseudomonas). submitting this cultures to the drugs sulfadiazine (su), streptomycin (sm), tetracycline (tc), chloramphenicol (cm), kanamycin (km ... | 1985 | 3837834 |
| temocillin. in vitro antibacterial activity. | temocillin, a 6-alpha-methoxy penicillin derivative, was tested in vitro against 516 recent clinical isolates of enterobacteriaceae. the compound exhibited good antibacterial activity, with 95% of isolates inhibited by a range 2 to 16 mg/l. further studies, against selected isolates resistant to ticarcillin, piperacillin and cefuroxime (klebsiella oxytoca, 25; enterobacter species, 34; and citrobacter species, 5), showed about half of the isolates of k. oxytoca (11/25) to be resistant to aztreon ... | 1985 | 3849425 |
| biochemical identification of new species and biogroups of enterobacteriaceae isolated from clinical specimens. | in 1972 there were only 11 genera and 26 species in the family enterobacteriaceae. today there are 22 genera, 69 species, and 29 biogroups or enteric groups. this paper is a review of all of the new organisms. it has a series of differential charts to assist in identification and a large chart with the reactions of 98 different organisms for 47 tests often used in identification. a simplified version of this chart gives the most common species and tests most often used for identification. the so ... | 1985 | 3881471 |
| aztreonam in the treatment of serious orthopedic infections. | aztreozam was evaluated in the treatment of a variety of orthopedic infections. included were 17 patients with osteomyelitis, three with purulent arthropathy with prostheses, and 16 with superficial infections secondary to trauma or surgical procedure. pathogens were gram-negative bacilli sensitive to aztreonam. concomitant antibiotics were administered for gram-positive cocci that were present initially or by superinfection. infecting organisms included pseudomonas aeruginosa (minimal inhibitor ... | 1985 | 3881949 |
| comparative activity of the penem antibiotic sch 34343 against gram-negative and gram-positive bacteria with special reference to multiresistant strains. | a new penem antibiotic, sch 34343, was shown to be active against a large number of gram-positive bacteria. the drug inhibited penicillinase-positive and -negative staphylococci equally well, being five times more active than cefamandole and ten times more active than methicillin. most methicillin-resistant staphylococci were inhibited by concentrations between 0.25 and 4 mg/l, but a small group of highly resistant strains were observed. sch 34343 was eight times less active than ampicillin and ... | 1985 | 3849537 |
| mezlocillin, ceftizoxime, and amikacin alone and in combination against six enterobacteriaceae in a neutropenic site in rabbits. | closed-space, locally neutropaenic infection sites were simulated in rabbits by implanting subcutaneous semipermeable chambers inoculated with 5 x 10(4) cfu/ml of escherichia coli (one strain), citrobacter diversus (one strain), klebsiella pneumoniae (two strains) or serratia marcescens (two strains). four hours after inoculation, treatment was begun with amikacin (15 mg/kg), mezlocillin (100 mg/kg), or ceftizoxime (50 mg/kg) alone or in two-drug combinations. antibiotics were given intramuscula ... | 1985 | 3856563 |
| [characteristics of the composition of the causative agents of different forms of suppurative inflammatory diseases and their antibiotic sensitivity]. | antibiotic sensitivity of 466 clinical strains of gram-positive and gram-negative microorganisms isolated from patients with different forms of pyoinflammatory diseases was studied. most of the staphylococcal isolates were resistant to benzylpenicillin (74.3 per cent). the number of the isolates resistant to erythromycin amounted to 59.6 per cent. the respective figures for methicillin and dicloxacillin were 17.9 and 10.8 per cent. staphylococci resistant to new aminoglycosides, fusidin and rifa ... | 1985 | 3933419 |
| [comparative studies of antimicrobial agents against causative organisms isolated from urinary tract infections (1983). iii. secular changes in susceptibility]. | the in vitro antimicrobial activities of antibiotics against causative pathogens isolated from patients with urinary tract infections (uti) in the 8 institutions in japan during the period from 1980 to 1983 were compared. a number of new beta-lactam antibiotics with broad spectrum of activity have become available for clinical use in recent years. some of them, in particular so-called third generation cephems, are reported to be responsible for developing microbial-cross resistance to multiple b ... | 1985 | 3935824 |
| [effect of ceftazidime on enterobacteria and pseudomonas producers of beta-lactamases]. | the activity of cephalotin, cefoxitin, cefamandole, cefoperazone, cefotaxime, latamoxef, thienamycin, azthreonam, cefsulodine and ceftazidime against beta-lactamase producing strains of enterobacteriaceae and pseudomonas was compared by determination of 99% inhibitory concentrations. the isogenic strains studied differed by a single genetic event: mutation, gene amplification, acquisition of a high or low copy-number plasmid or of a transposon and were representative of the major known mechanism ... | 1985 | 3936006 |
| toxic exoproducts of citrobacter freundii. | a strain of citrobacter freundii isolated from the feces of a patient with diarrhoea was examined for growth kinetics and toxic exoproduct formation using the complete (bhi) and synthetic culture media. it was found that the test organism in synthetic medium grew distinctly slower than in bhi. fractionations on sephadex g-100 column yielded 3 fractions from the complete medium culture filtrate and 2 fractions from the culture filtrate obtained from synthetic medium. the first culture filtrate fr ... | 1985 | 3936878 |
| bacteriology and ultrastructure of the bladder in patients with urinary tract infections. | tissue obtained by biopsy of the bladder from 33 patients with various urinary tract symptoms was studied by conventional bacteriological techniques and by scanning electron microscopy (sem). all the patients had recurrent urinary tract symptoms which had not completely responded to antibiotic therapy. eleven of the patients had greater than or equal to 10(8) colony-forming units (cfu) of bacteria/1 urine; six had between 10(6) and 10(7) cfu/1, and 16 were abacteruric. bacteria were isolated, ho ... | 1985 | 3936879 |
| comparison of the exoproducts of gram-negative bacteria by sds-page. | the protein exoproducts released during exponential growth of gram-negative bacteria were analysed and compared by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (sds-page). the following bacterial strains were tested: escherichia coli, klebsiella pneumoniae, citrobacter freundii, enterobacter cloacae, serratia liquefaciens, serratia rubidaea, proteus mirabilis, proteus vulgaris, salmonella minnesota, pseudomonas aeruginosa and pseudomonas fluorescens. it is demonstrated by sds-page t ... | 1985 | 2408403 |
| [protective action of a corpuscular polyvalent pseudomonas aeruginosa vaccine against representative enterobacteria]. | animal experiments have demonstrated that p. aeruginosa vaccine is capable of protecting animals from experimental p. aeruginosa infection, as well as rendering a protective effect with respect to some representatives of the family enterobacteriaceae. the comparative study of the antigenic spectra of the vaccine strains and some representatives of enterobacteriaceae (enterobacter, serratia, citrobacter and klebsiella) has revealed no direct relationship between the degree of this protective effe ... | 1985 | 2409719 |
| [in vitro activity of ceftriaxone on hospital bacteria. results of a multicenter study]. | minimal inhibitory concentrations (mics) of ceftriaxone were determined by agar dilution for 2 099 strains isolated in six teaching hospitals. mics were less than 1 microgram/ml for the great majority of enterobacteriaceae, with mode mics varying across groups from less than 0.008 micrograms/ml for proteus (mirabilis and indole-positive) to 0.25 for enterobacter. only a few resistant strains were found, mainly among enterobacter and citrobacter. ceftriaxone proved noticeably less active against ... | 1985 | 2868442 |
| [vi antigen and microbial adhesion factors. the detection of adhesins in commercial vi antigen preparations]. | enterobacterial vi-antigen inhibit the escherichia coli-induced agglutination of red blood cells of guinea pigs and other animals, which indicates that vi-antigen contains the admixture of adhesion associated with type i pili. the amount of adhesion contained in vi-antigen can be determined from the degree to which its hemagglutination-inhibiting effect is manifested. | 1985 | 2868591 |
| reactions of fish to microorganisms in wastewater. | fish were inoculated with various microorganisms present in wastewater. a threshold concentration was determined over which these microorganisms were recovered from the muscles. the threshold concentrations were different for bacteria, bacteriophages, and polio 1 lsc virus. the threshold values were lower when fish were inoculated than when they were immersed in water containing these organisms. depuration experiments were efficient when the fish did not contain high concentrations of bacteria i ... | 1985 | 3002273 |
| aztreonam in the treatment of bone and joint infections caused by gram-negative bacilli. | aztreonam was used successfully in 17 of 17 patients with orthopedic infections due to gram-negative bacilli (11, osteomyelitis; six, septic arthritis). duration of treatment ranged from 14 to 55 days, and the period of follow-up was four to 18 months. causative organisms included pseudomonas aeruginosa, serratia marcescens, enterobacter gergoviae, citrobacter diversus, proteus mirabilis, and enterobacter aerogenes. aztreonam was well tolerated. the only definite reactions attributable to aztreo ... | 1985 | 2934786 |
| effect of an activated sludge wastewater treatment plant on ambient air densities of aerosols containing bacteria and viruses. | bacteria- and virus-containing aerosols were studied during the late summer and fall seasons in a midwestern suburb of the united states before and during the start-up and operation of an unenclosed activated sludge wastewater treatment plant. the study showed that the air in this suburban area contained low-level densities of indicator microorganisms. after the plant began operating, the densities of total aerobic bacteria-containing particles, standard plate count bacteria, total coliforms, fe ... | 1985 | 2988442 |
| purification and characterization of selenocysteine beta-lyase from citrobacter freundii. | the purification and characterization of bacterial selenocysteine beta-lyase, an enzyme which specifically catalyzes the cleavage of l-selenocysteine to l-alanine and se0, are presented. the enzyme, purified to near homogeneity from citrobacter freundii, is monomeric with a molecular weight of ca. 64,000 and contains 1 mol of pyridoxal 5'-phosphate as a cofactor per mol of enzyme. l-selenocysteine is the sole substrate (km, 0.95 mm). l-cysteine is a competitive inhibitor of the enzyme (ki, 0.65 ... | 1985 | 2991201 |
| regulatory components in citrobacter freundii ampc beta-lactamase induction. | citrobacter freundii encodes an inducible chromosomal beta-lactamase similar to the constitutively expressed ampc beta-lactamase of escherichia coli. in the latter species the ampc gene is located next to the fumarate reductase (frd) operon, whereas in c. freundii the ampc gene is known to be separated from frd by 1100 base pairs. this intervening dna segment carries a gene, ampr, coding for a 31-kilodalton polypeptide. the cloned c. freundii os60 ampc gene is inducible by beta-lactam antibiotic ... | 1985 | 2991883 |
| citrobacter lipopolysaccharides: structure elucidation of the o-specific polysaccharide from strain pcm 1487 by mass spectrometry, one-dimensional and two-dimensional 1h-nmr spectroscopy and methylation analysis. | structural studies on the o-specific polysaccharide of citrobacter pcm 1487 lipopolysaccharide, using methylation analysis, smith degradation and 1h-nmr spectroscopy, indicate that it consists of the trisaccharide repeating units (formula, see text) in this structure, 4-deoxy-d-arahex stands for 4-deoxy-d-arabino-hexose. | 1985 | 2982602 |
| characterization of restriction-modification enzymes cfr13 i from citrobacter freundii rfl13. | this communicatiopn describes some properties of rcfr13 i and mcfr13 i, isolated from citrobacter freundii rfl13. rcffr13 i restriction enzyme recognizes the 5'-g gncc sequence and cleaves, as indicated by the arrow. mcfr13 i methylase modifies the internal cytosine producing m5c (5'-ggnm5cc). rcfr13 i is sensitive not only to this type of substrate modification but also to hemimethylation in overlapping sites by mcfr10 i (internal cytosine of rcfr13 i recognition is methylated) and mhpa ii (ext ... | 1985 | 2984047 |
| [differences in the production of temperate bacteriophages in lysogenic strains of salmonella enteritidis and citrobacter]. | 1985 | 3160495 | |
| [the toxigenicity of strains of citrobacter freundii]. | 1985 | 3157464 | |
| in vitro antibacterial activity of norfloxacin and other agents against ocular pathogens. | 302 clinical isolates representing 16 bacterial species most often implicated in ocular infections were tested in vitro against norfloxacin and a panel of antibacterial agents. on the basis of the 90% minimal inhibitory concentration (mic90) data, norfloxacin was 4-32 times more active than the next best antimicrobial tested against citrobacter freundii, escherichia coli, morganella morganii, proteus mirabilis, proteus vulgaris, haemophilus influenzae, neisseria gonorrhoeae and staphylococcus ep ... | 1985 | 3157551 |
| [antimicrobial activity of cefotiam against various clinical isolates from 1981 to 1985]. | some of new cephem antibiotics, particularly the so called the third generation cephalosporins, are reported to be potent inducers of beta-lactamases and to be responsible for developing microbial cross-resistance to multiple beta-lactam antibiotics and occasionally to the aminoglycosides (sanders and sanders, 1983). in japan, third generation cephalosporins such as cefotaxime, cefoperazone, ceftizoxime, and latamoxef became available in 1981, and cefmenoxime in 1982. therefore, it is of interes ... | 1986 | 3467078 |
| antimicrobial activity of imipenem against 1386 clinical isolates. | 1386 isolates from clinical specimens were tested against imipenem by disc agar diffusion. the bacteria used in this study consisted of escherichia coli, enterobacter aerogenes, e. agglomerans, e. cloacae, klebsiella pneumoniae, k. oxytoca, k. ozanae, proteus mirabilis, p. vulgaris, providencia stuartii, p. rettgeri, acinetobacter calcoaceticus, citrobacter diversus, c. freundii, morganella morganii, serratia liquefaciens, s. marcescens, hafnia alvei, aeromonas hydrophila, pseudomonas aeruginosa ... | 1986 | 3468319 |
| evaluation of imipenem/cilastatin against nosocomial infections and multiresistant pathogens. | thirty-five patients suffering from soft tissue infections (12), upper utis (6), bronchopneumonia (6), septicaemia (2), chronic osteomyelitis (2), intra-abdominal abscess (2), liver abscess (1), lung abscess (1), acute cholangitis (1), thoracic empyema (1) and chronic prostatitis (1) were given imipenem/cilastatin for 6-21 days. in 22 patients several aggravating factors coexisted, while infection in 16 patients was polymicrobial. the following pathogens were implicated: pseudomonas aeruginosa ( ... | 1986 | 3469191 |
| inducible type i beta-lactamases of gram-negative bacteria and resistance to beta-lactam antibiotics. | mutants, showing either constitutive (depressed) or non-inducible expression of chromosomally-mediated type i beta-lactamase were obtained from clinical isolates of enterobacter cloacae, ent. aerogenes, citrobacter freundii, providencia stuartii, morganella morganii, serratia marcescens and pseudomonas aeruginosa. the wild-type and mutant strains were compared for susceptibility to a range of beta-lactam antibiotics. derepression of beta-lactamase synthesis generally, but not always, resulted in ... | 1986 | 3485092 |
| the activity of bmy 28142 a new broad spectrum beta-lactamase stable cephalosporin. | the in-vitro activity of bmy 28142, an iminomethoxy, aminothiazolyl cephalosporin containing a methyl pyrrolidinio c-3 was compared with that of cefotaxime, ceftazidime, aztreonam, imipenem and tobramycin against various bacteria. bmy 28142 was the most active agent tested against the enterobacteriaceae inhibiting 90% at less than or equal to 1 mg/l. the in-vitro activity of bmy 28142 was equal to or superior to cefotaxime against the highly susceptible members of the enterobacteriaceae and seve ... | 1986 | 3486862 |
| in vitro activity and beta-lactamase stability of two oral cephalosporins, ceftetrame (ro 19-5247) and cefetamet (ro 15-8074). | ceftetrame (ro 19-5247) and cefetamet (ro 15-8074), two new orally administered aminothiazolyl imimomethoxy cephalosporins, inhibited hemolytic streptococci and streptococcus pneumoniae at less than or equal to 0.5 micrograms/ml but were less active against staphylococci than were cephalexin and cefaclor. they did not inhibit s. faecalis, s. faecium, listeria monocytogenes, corynebacterium jk species, or pseudomonas aeruginosa. haemophilus influenzae, branhamella catarrhalis, and neisseria gonor ... | 1986 | 3490827 |
| microbiological perspective of ketoconazole. | the analysis of the results obtained in our trials, which took into account different experimental conditions, suggests that ketoconazole is a very effective anti-candida drug. in particular, ketoconazole inhibits the development of the hyphal form of c. albicans which is highly invasive. in our trials, we were also able to demonstrate that it is possible to extend ketoconazole's range of action to gram-negative bacteria, if the drug is used in appropriate pharmaceutical forms. moreover, its in ... | 1986 | 3518964 |
| synergism and antagonism in double beta-lactam antibiotic combinations. | combinations of two beta-lactam antibiotics may be advantageous in certain clinical situations, providing a synergistic activity against specific organisms or a broad spectrum of antibiotic coverage. depending on the combination and the bacteria, synergism, indifference, or antagonism can be observed. synergism may occur when two beta-lactam antibiotics, acting on different penicillin-binding proteins, are combined or when a penicillinase-susceptible beta-lactam antibiotic is protected by anothe ... | 1986 | 3487247 |
| isolation, characterization, and mode of action on escherichia coli strains of microcin d93. | microcin d93 is an antibiotic substance produced by escherichia coli strains which harbor the 5.5-kilobase plasmid pmccd93. its production is unaffected by the use of different carbon and ammonia sources, different phosphate concentrations, or mitomycin c. we developed a method for purifying this microcin based on gel permeation chromatography and reverse-phase high-pressure liquid chromatography. the antibiotic appears to be a small, hydrophilic, basic peptide, active on e. coli and proteus, ci ... | 1986 | 3521486 |
| 7 alpha-formylamino substituent confers beta-lactamase-inactivating potency on 1-oxacephalosporins. | 7 alpha-formylamino-1-oxacephalosporins 7 alpha-formylamino-7 beta-[2- (methylaminocarbonyl)amino-2-(2-thienyl)acetamido]-3-[(1-methyl-1h -tetra zol-5-yl)thiomethyl]-1-oxa-3-cephem-4-carboxylic acid (f1) and 7 alpha-formylamino-7 beta-(2-[(4-ethyl-2,3-dioxopiperazine-1- yl)carbonylamino]-2-phenylacetamido)-3-[(1-methyl-1h-tetr azol-5-yl) thiomethyl]-1-oxa-3-cephem-4-carboxylic acid (f2) were stable against penicillinases and, moreover, inactivated cephalosporinases of pseudomonas aeruginosa, cit ... | 1986 | 3490828 |
| mutation of escherichia coli capable of expressing gene(s) for beta-lactamase production of citrobacter freundii. | a mutation in a chromosomal gene of escherichia coli, designated reb, acted in trans to increase the expression of the cloned beta-lactamase gene of citrobacter freundii. the reb gene was located around 99 min. deletion mutants in the cloned gene(s) which had lost the regulatory region for induction were also constructed. | 1986 | 3518627 |
| in vitro activity and beta-lactamase stability of a new difluoro oxacephem, 6315-s. | 6315-s, a novel difluoromethyl thioacetamido oxacephem, had in vitro activity comparable to that of cefotaxime and moxalactam against escherichia coli, klebsiella pneumoniae, proteus mirabilis, klebsiella oxytoca, citrobacter diversus, salmonella spp., and shigella spp., inhibiting 90% at less than or equal to 0.25 microgram/ml. it inhibited piperacillin- and cefoperazone-resistant isolates in these species. 6315-s did not inhibit cefotaxime- or moxalactam-resistant citrobacter freundii, enterob ... | 1986 | 3492172 |
| beta-lactamase stability of cefpirome (hr 810), a new cephalosporin with a broad antimicrobial spectrum. | cefpirome was highly stable to hydrolysis by various beta-lactamases, although it was hydrolyzed to some extent by r plasmid-mediated penicillinase of richmond-sykes type va/b and by chromosomal cephalosporinases from bacteroides species. the compound had a very low affinity for cephalosporinases from enterobacter cloacae, citrobacter freundii, serratia marcescens, and proteus vulgaris. cefpirome showed strong antimicrobial activity against eight beta-lactamase (cephalosporinase)-producing strai ... | 1986 | 3492175 |
| delayed inactivation of citrobacter freundii cephalosporinase by 6 beta-[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]penicillin sulfone. | when citrobacter freundii cephalosporinase was incubated with 6 beta-[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]penicillin sulfone (cloxacillin sulfone) in phosphate buffer, the enzyme was suddenly inactivated just after the completion of enzymatic degradation of the cloxacillin sulfone. such delayed inactivation was due to a secondary inhibitor formed from cloxacillin sulfone during the incubation period. the inactivation was delayed due to the protection of the enzyme by cloxacillin sulfone fro ... | 1986 | 3493233 |
| outer membrane permeability of imipenem in comparison with other beta-lactam antibiotics. | 1986 | 3512504 | |
| unusual mucocutaneous infections in immunosuppressed patients with leukemia--expansion of an earlier study. | 1986 | 3513146 | |
| comparison of the standard pour plate procedure and the atp and limulus amebocyte lysate procedures for the detection of microbial contamination in intravenous fluids. | the intrinsic and extrinsic microbial contamination of large-volume parenterals has been associated with bacteremias in hospitalized patients. when epidemiologic data suggest the association of contaminated intravenous (i.v.) fluids with disease, appropriate laboratory methods must be devised to analyze quickly the suspect fluid. a study was undertaken to compare three laboratory test methods (standard pour plate [spp] technique, atp procedure, and limulus amebocyte lysate [lal] assay) for detec ... | 1986 | 3514657 |
| sonographic demonstration of prostatic abscess. | 1986 | 3514932 | |
| the antimicrobial activities of trimethoprim and sulfonamides. | the folate inhibitor trimethoprim (tmp) is active against and potentially cidal to a few higher microorganisms and a wide spectrum of pathogenic bacteria except for bacteroides, branhamella, brucella, chlamydia, clostridium, mycobacterium, mycoplasma, nocardia, neisseria, pseudomonas and treponema. these organisms tend to be more sensitive to sulfonamides (sul) than to tmp, whereas tmp is 10- to 100-fold more active than sul against most other bacteria. synergy between tmp and sul occurs at drug ... | 1986 | 3515508 |
| effect of inoculum size on ampicillin and amoxycillin susceptibility determined by gas-liquid chromatography for members of the family enterobacteriaceae. | inoculum size had only a small effect on the results for ampicillin and amoxycillin susceptibility testing of escherichia coli. in contrast, a difference in inoculum size from 10(6) to 10(8) cfu/ml profoundly affected the results for ampicillin and amoxycillin susceptibility testing of proteus mirabilis, causing a change from susceptibility to complete resistance. these different effects of inoculum size were observed both when susceptibility was determined by the suppression of a characteristic ... | 1986 | 3517063 |
| bacterial antagonists of shigellae. | bacterial antagonism between a microorganisms and shigella sonnei strains was studied in model experiments simulating conditions of the natural aquatic environment. in these studies surface waste samples from the river vltava served as the experimental environment. to ensure bacteriologically defined conditions all water samples were heat-sterilized prior to antagonism testing. consistently with the literature data and author's own observations the following bacterial species and genera were cho ... | 1986 | 3522730 |
| evaluation of a commercial beta-glucuronidase test for the rapid and economical identification of escherichia coli. | a commercial beta-glucuronidase (beta-gur) test for the rapid and economical identification of escherichia coli was evaluated. a total of 762 clinical strains and 228 environmental isolates were studied. more than 95% of the e. coli strains were found to be beta-gur positive. thirty-one clinical isolates of shigella sonnei, 10 of enterobacter cloacae, eight of enterobacter aerogenes, nine of citrobacter freundii and one of salmonella enteritidis also gave positive results. the enzyme beta-gur wa ... | 1986 | 3549665 |
| [diagnostic problems in spontaneous bacterial peritonitis]. | in spontaneous bacterial peritonitis (sbp) the ascitic fluid culture (certain criterion of diagnosis) may be negative despite an evident clinical and biochemical picture. therefore the diagnosis may be sometimes more "probable" than "certain". the authors performed a comparative analytical study--from a clinical, biochemical and prognostic point of view--between a group of 10 "probable" sbp (10 cirrhotic pts.) and 9 "certain" sbp (9 cirrhotic pts.). 115 "normal ascitic fluids" (negative culture ... | 1986 | 3523299 |
| improved immunological membrane filter method for detection of food-borne salmonella strains. | an improved membrane filter method that involves the use of an enzyme-labeled antibody stain has been developed for the rapid detection of salmonella species in foods. the procedure is carried out directly on a hydrophobic grid-membrane filter without requiring transfer by blotting to nitrocellulose. pure cultures of 54 salmonella species and 10 foods artificially contaminated with salmonella colindale gave a positive reaction in which salmonella colonies were visible as purple dots. of 11 nonsa ... | 1986 | 3524458 |
| contribution of chromosomal beta-lactamases to beta-lactam resistance in enterobacteria. | the two most important factors determining the level of beta-lactam resistance to novel cephalosporins in gram-negative enterobacteria are the chromosomal class c beta-lactamases, which have high affinity for these compounds, and the outer membrane permeability barrier. the individual importance of these factors and the interactions between them are discussed. wild-type strains carry a chromosomal gene, ampc, encoding class c beta-lactamases. expression from this gene is normally low, but it can ... | 1986 | 3529322 |
| ferric ammonium citrate decomposition--a taxonomic tool for gram-negative bacteria. | the iron uptake test of szabó and vandra has been modified and used for the differentiation of gram-negative bacteria. nutrient agar containing 20 g per litre of ferric ammonium citrate was distributed into narrow tubes and solidified so as to form butts and slants. considering the localization of the rusty-brown coloration produced after seeding and incubation, 2367 strains were classified into four groups. (1) unchanged medium: escherichia coli, shigella spp., yersinia spp., hafnia alvei and m ... | 1986 | 3529797 |
| the in-vitro activity and beta-lactamase stability of carumonam. | carumonam is a monobactam with a beta-carbamyloxmethyl group at position 4. it inhibited 90% of enterobacteriaceae at less than or equal to 8 mg/l and had in-vitro activity similar to that of cefotaxime, ceftazidime and aztreonam. fifty per cent of enterobacter, citrobacter and serratia isolates were inhibited by 4 mg/l, but isolates resistant to aztreonam and ceftazidime were not inhibited. carumonam, like aztreonam, did not inhibit gram-positive or anaerobic species. carumonam was not destroye ... | 1986 | 3531143 |
| [multicenter study of ofloxacin activity on bacteria isolated from a hospital environment]. | minimal inhibitory concentrations (mics) of ofloxacin were evaluated by agar dilution for 1508 bacterial strains isolated in five hospitals. for enterobacteriaceae sensitive to nalidixic acid, mics ranged from 0.008 to 1 microgram/ml (mode mic: 0.12); the different species of enterobacteriaceae exhibited similar mode mics (0.12) with the exception of e. coli (0.06-0.12), p. mirabilis (0.5) and providencia (0.25). among strains intermediate and resistant to nalidixic acid, most of which were serr ... | 1986 | 3534711 |
| [ofloxacin (ru 43280): clinical evaluation in urinary and prostatic infections]. | ofloxacin, a new fluoroquinolone, was given to fifty patients (29 females and 21 males) aged 25 to 86 years with urinary tract infection or prostatitis. urinary tract infections usually chronic and associated with urologic anomalies, included 17 cases of cystitis and 19 cases of pyelonephritis. 14 patients had prostatitis. pathogens recovered from the urine were 26 e. coli, 2 citrobacter, 4 proteus mirabilis, 2 klebsiella, 2 enterobacter, 3 serratia, 3 staphylococcus aureus and 11 pseudomonas. m ... | 1986 | 3534729 |
| [bactericidal activity of ceftriaxone, amikacin and their combination]. | third-generation cephalosporins such as ceftriaxone are often used alone; however, with enterobacter (ent), citrobacter (cit), serratia (ser) and morganella (mor), a combination of two drugs is advisable. aminoglycoside-beta-lactam combinations are often synergistic. however, results are not consistent with the new cephalosporins. we determined the killing kinetics of ceftriaxone (c) alone, amikacin (a) alone and both drugs in combination (ac). the antibiotics were tested in the following concen ... | 1986 | 3534741 |
| [in vitro activity of a new 3d-generation cephalosporin, cefodizime, on hospital bacteria]. | minimal inhibitory concentrations (mics) of cefodizime were evaluated by agar dilution for 746 bacterial strains isolated in two hospitals. for enterobacteriaceae mics ranged from 0.008 micrograms/ml to more than 128 micrograms/ml (mode mic: 0.25); mode mics varied across species, ranging from 0.016 micrograms/ml for proteus mirabilis to 1 microgram/ml for citrobacter; mics ranged from 0.12 to 8 for most enterobacter and from 1 to 64 for serratia. the rare cefotaxime-resistant strains, most of w ... | 1986 | 3534743 |
| [in vitro activity of carumonam (ro 17-2301) on hospital bacteria]. | minimal inhibitory concentrations (mics) of carumonam (ro 17-2301), a new synthetic antibacterial agent of the monobactam group, were evaluated by agar dilution for 399 hospital isolates. ro 17-2301 was inactive against gram positive and anaerobic bacteria. most enterobacteriaceae were inhibited by concentrations less than 1 microgram/ml, with mode mics approximating 0.03 micrograms/ml except for providencia (0.016), citrobacter (0.06), serratia (0.06) and enterobacter (0.12). a few strains, mos ... | 1986 | 3534745 |
| magnesium-dependent plaque formation by bacteriophage p1cinc(-) on escherichia coli c and shigella sonnei. | phage p1c(-), in a state of the phage not infective to escherichia coli k12, was able to form plaques on a wild-type strain of e. coli c and on shigella sonnei in the presence of mg2+. citrobacter freundii, enterobacter aerogenes, and a salmonella typhimurium gale mutant were not lysed by, but were lysogenized with p1cinc(-), whereas klebsiella pneumoniae, proteus rettgeri, and s. typhimurium lt2 were not susceptible to either p1cinc(-) or p1cinc(+). the lipopolysaccharide structure of e. coli c ... | 1986 | 3535235 |
| [infectious endocarditis in hypertrophic obstructive cardiomyopathy]. | clinical and pathological findings in a 37-year-old female patient with hocm and infective endocarditis of the aortal and mitral valves were reported. the patient died of septic shock. infective endocarditis with acute insufficiency of the aortal and/or mitral valves is a severe complication in patients with hocm, because the left ventricle with a disturbed compliance is unable to compensate the acute volume overload. the standard use of nitrates for congestive lung failure and catecholamines fo ... | 1986 | 3535276 |
| the use of normal filter paper for "dot-immunobinding assay" of some antibodies. | normal filter papers were used for specific detection of tiny amounts of antibodies against two penicillin amidase molecular forms from escherichia coli, monoclonal antibodies of igg and igm class against lipopolysaccharide from citrobacter o36 and igm antibody against glycoprotein n from human red blood cells. for colour detection of antibodies bound to proper antigens adsorbed on the paper, second antibody-horse radish peroxidase conjugates and hydrogen peroxide with 4-chloronaphthol were appl ... | 1986 | 3535727 |
| in vitro activity of carumonam (ro 17-2301), bmy-28142, aztreonam, and ceftazidime against 7,620 consecutive clinical bacterial isolates. | for 45-60 days four geographically separate clinical laboratories tested routine clinical bacterial isolates for susceptibility to carumonam, aztreonam, bmy-28142, and ceftazidime by the broth microdilution method. all four drugs were highly active against enterobacteriaceae, inhibiting greater than 96% of the 4887 strains tested at less than or equal to 8.0 microgram/ml. the minimal inhibitory concentration at which 50% of the isolates were inhibited for each drug was less than or equal to 0.12 ... | 1986 | 3536278 |
| prevalence of colonization with antibiotic resistant gram-negative bacilli in a nursing home care unit: the importance of cross-colonization as documented by plasmid analysis. | a prevalence study was carried out on a 100-bed veterans administration nursing home care unit to determine the extent of colonization with gentamicin-resistant gram-negative bacilli (grgnb). hand cultures of 12 employees and 17 environmental cultures were negative. twenty-six of 86 (30%) patients were colonized with 49 grgnb. sixteen patients (19%) had urinary colonization. multivariate analysis revealed significant associations between rectal or perineal colonization (p less than 0.01), and th ... | 1986 | 3536783 |
| in vitro activity against aerobic and anaerobic gram-positive and gram-negative bacteria and beta-lactamase stability of rs-533, a novel carbapenem. | rs-533 is a novel carbapenem antibiotic. its activity was compared with that of imipenem and the new cephalosporins, aztreonam, piperacillin, and tobramycin. rs-533 had activity comparable to that of imipenem, inhibiting the majority of the enterobacteriaceae, streptococci, staphylococci, and bacteroides species at concentrations of less than or equal to 2 micrograms/ml. rs-533 inhibited enterobacter cloacae, citrobacter freundii, and serratia marcescens resistant to ceftazidime, aztreonam, and ... | 1986 | 3545068 |
| chromosomal beta-lactam resistance in enterobacteria. | most enterobacterial species carry a chromosomal ampc beta-lactamase gene. in escherichia coli and shigella, expression from ampc is non-inducible and the beta-lactamase is synthesized at low levels. mutations leading to increased beta-lactamase synthesis occur rather infrequently, making resistance to modern cephalosporins a rare event in these species. in other enterobacteria and pseudomonas, ampc beta-lactamase synthesis is induced by beta-lactams. in enterobacter cloacae, citrobacter freundi ... | 1986 | 3547624 |
| antibiotics in the second half of the 1980s. areas of future development and the effect of new agents on aminoglycoside use. | articles in this supplement have examined in detail the role of aminoglycosides in the therapy of infections, addressing problems of resistance, toxicity, and efficacy. this article discusses other agents and their potential utility and effect on aminoglycosides. penem antibiotics, which have activity against only aerobic gram-negative bacteria, have recently been synthesized. these agents have proved effective in animal experiments; to date, however, results of human clinical trials are not ava ... | 1986 | 3460336 |
| [concomitant therapy with cefmenoxime and cefsulodin for refractory complicated urinary tract infection (especially caused by pseudomonas aeruginosa)]. | cefmenoxime (2 g) and cefsulodin (1 g) were given twice daily for 5 days by concomitant intravenous drip infusion (mixed infusion) to 135 patients with complicated urinary tract infection (c-uti) probably caused by pseudomonas aeruginosa. the clinical efficacy was evaluated according to the criteria proposed by the uti committee in japan. ninety one subjects met the criteria for c-uti and were evaluable for drug efficacy. p. aeruginosa was detected in 44 cases (including mixed infection with oth ... | 1986 | 3463188 |
| sequence of the citrobacter freundii os60 chromosomal ampc beta-lactamase gene. | the citrobacter freundii os60 ampc beta-lactamase gene was sequenced and found to encode a 380-amino-acid-long precursor with a 19-residue signal peptide. the mature protein has a predicted molecular mass of 39781 da. the first 60 residues of the purified enzyme, as determined by sequential edman degradation, are identical to the amino acid sequence inferred from the gene sequence. also, the amino acid composition determined for the purified beta-lactamase and that given by the gene sequence are ... | 1986 | 3486121 |
| gram-negative septicemia in american alligators (alligator mississippiensis). | six species of bacteria (family enterobacteriaceae) not commonly reported as associated with disease in american alligators (alligator mississippiensis) were documented, suggesting that aeromonas is not the only bacterium responsible for septicemia in crocodilians. these included citrobacter freundii, enterobacter agglomerans, proteus sp., morganella morganii, serratia marcescens, and klebsiella oxytoca. clinical signs of disease included intensive basking, anorexia, lethargy, flaccid limb paral ... | 1986 | 3503133 |
| inhibitory and bactericidal activity of cefmetazole and seven other beta-lactams against different bacterial inocula. | the determination of the minimal inhibitory concentrations (mics) at different bacterial inocula represents an important factor in determining the potential effectiveness of new antibiotics. mics at different inocula (10(5) and 10(7) cfu/ml) and minimal bactericidal concentrations (mbc) of cefmetazole and seven other new cephalosporins (ceftazidime, ceftizoxime, cefamandole, ceftriaxone, cefotaxime, cefuroxime, cefoxitin) were determined by a miniaturized dilution broth method against a wide ran ... | 1986 | 3518963 |
| polyarthritis and polyosteomyelitis in a juvenile giraffe. | 1986 | 3505975 | |
| antimicrobial activity and beta-lactamase stability of sk&f 88070 compared with other agents. | the in vitro activity and beta-lactamase stability of sk&f 88070 (7-[[2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[ [1-(2-sulfaminoethyl)-1h-tetrazol-5-yl]thio]methyl]-3- cephem-4-carboxylic acid) a new parenteral cephalosporin was investigated against 780 types of bacteria. sk&f 88070 inhibited 90% of escherichia coli, klebsiella pneumoniae, proteus mirabilis, salmonella species, shigella species, morganella morganii, and citrobacter diversus at less than or equal to 0.5 micrograms/ml. i ... | 1986 | 3485506 |
| [antibacterial activity of cephem antibiotics against isolates from clinical specimens at the yokohama city university hospital]. | minimum inhibitory concentrations (mics) of cephem antibiotics against 405 strains belonging to 17 species of clinical isolates were investigated using the standard method of the japanese congress of chemotherapy. the results obtained are summarized below. cephem antibiotics showed weak antibacterial activities against enterococcus sp., b. fragilis and s. marcescens. s. pneumoniae, s. agalactiae, e. coli, k. pneumoniae and p. mirabilis were susceptible to cephem antibiotics. cephem antibiotics o ... | 1986 | 3543429 |
| microbial pollution indicators in brazilian tropical and subtropical marine surface waters. | the specificity of indicators that depend on elevated incubation temperature as a selective factor for their enumeration was questioned because of the possibility of interference from autochthonous microorganisms adapted to high ambient temperatures. lactose-fermenting cultures isolated from fecal coliform tests of tropical marine surface waters were identified as consisting of about 70% escherichia coli, and most of the remaining cultures being klebsiella, enterobacter or citrobacter species. t ... | 1986 | 3544214 |
| o-nitrophenyl-beta-d-galactopyranoside-urease-indole broth, a new composite tube medium for salmonella screening. | a new composite broth medium combining o-nitrophenyl-beta-d-galactopyranoside (onpg) and urease and indole tests in a single tube is described. high-level agreement with individual conventional tests was recorded in comparative studies with 2,412 cultures of members of the family enterobacteriaceae, i.e., 100% agreement with the exception of hafnia spp. (96.3% agreement) for the onpg test and citrobacter, enterobacter, and hafnia spp. (75, 86.4, and 98.2% agreement, respectively) for the urease ... | 1986 | 3639886 |
| in-vitro activity of pefloxacin compared to other antibiotics. | pefloxacin is a new quinolone carboxylic acid with a broad spectrum of antibacterial activity. a comparison was made of the in-vitro activity of pefloxacin and that of nine other antibiotics (ampicillin, ticarcillin, piperacillin, cefazolin, cefotaxime, ceftazidime, gentamicin, amikacin and norfloxacin). the mic90 of pefloxacin against 500 strains of enterobacteriaceae ranged from 0.25 mg/l (escherichia coli, indole + proteus spp., enterobacter cloacae, salmonella spp. and shigella spp.) to 1 mg ... | 1986 | 3086279 |
| in vitro activity of aztreonam against gram negative bacteria from clinical specimens and its comparison with other commonly used antibiotics. | a total of 755 gram negative bacteria isolated from clinical specimens were tested against aztreonam by the disc agar diffusion test. the strains of bacteria used in this study consisted of escherichia coli (314), enterobacter aerogenes (30), e. agglomerans (7), e. cloacae, (39), citrobacter diversus (9), c. freundii (13), hafnia alvei (3), acinetobacter calcoaceticus (10), klebsiella oxytoca (6), k. ozaenae (5), k. pneumoniae (107), morganella morganii (3), moraxella sp. (10), pasteurella multo ... | 1986 | 3088346 |
| aminoglycosides plus beta-lactams against gram-negative organisms. evaluation of in vitro synergy and chemical interactions. | combination antibiotic therapy has been used mainly to broaden the antibacterial spectrum and prevent the development of resistance. antibiotic combinations proven to be synergistic in vitro are associated with a significantly better in vivo response, particularly in the compromised host in whom traditional treatment combines an antipseudomonal penicillin plus an aminoglycoside. several investigators have examined combining new agents, such as the third-generation cephalosporins (cefotaxime, cef ... | 1986 | 3088998 |
| growth of salmonellas in different enrichment media. | the usefulness of selenite-f (s-f), tetrathionate (mkt) and rappaport-10 (r-10) broths as enrichment media to support growth of salmonellas either alone or in the presence of other competing organisms was studied. their ability to support the growth of stressed salmonellas from water was also investigated. it was observed that r-10 was more inhibitory to competing organisms than mkt and s-f. it strongly inhibited the growth of pseudomonas aeruginosa, citrobacter freundii and proteus vulgaris tho ... | 1986 | 3093439 |
| aztreonam in the treatment of severe urinary tract infections in pediatric patients. | aztreonam was administered to 30 patients, ages 0.03 to 15.4 years, with severe and in 21 cases complicated urinary tract infections caused by members of the family enterobacteriaceae and pseudomonas aeruginosa which were resistant to ampicillin and susceptible to the study drug in vitro. a mean dose of 47.7 mg/kg was given intramuscularly every 12 h to 26 patients. in four patients with renal insufficiency, the dose was reduced according to pharmacokinetic data. permanent urine sterilization an ... | 1986 | 3094442 |
| [in-vitro activity of cefonicid on hospital bacteria. regression line and proposal for critical values]. | antimicrobial activity of cefonicid, a new second generation cephalosporin, against 315 hospital isolates (4th trimester 1984) was investigated. e. coli and proteus mirabilis were the most susceptible species. all e. coli strains except one were inhibited at 8 mg/l (modal mic: 0.5); mics of all indole + proteus were 8 mg/l (modal mic: 0.06). another group was moderately susceptible: mics of klebsiella and citrobacter ranged from 0.12 to 128 mg/l, but mics of 50% of these strains were less than o ... | 1986 | 3095773 |
| [catalase-negative citrobacter freundii isolated from the urinary tract]. | 1986 | 3098867 | |
| in vitro activity of sch-34343, a new penam, and other antimicrobial agents against clinical isolates from cancer patients. | the in vitro activity of sch-34343, a new penam antibiotic, was tested against gram-positive and gram-negative isolates from cancer patients, and compared to that of 7 other antimicrobial agents. sch-34343 was extremely active against the enterobacteriaceae with mic90 ranging from 0.39 to 6.25 micrograms/ml for citrobacter spp., enterobacter spp., escherichia coli, klebsiella spp., proteus spp. and serratia marcescens. it was less active against acinetobacter spp. (mic90 6.25-12.5 micrograms/ml) ... | 1986 | 3100147 |
| the effects on beta-lactam susceptibility of phenotypic induction and genotypic derepression of beta-lactamase synthesis. | we have compared the ability of beta-lactam antibiotics to induce beta-lactamase synthesis and antagonize the in-vitro activity of other beta-lactams and also to select mutants with derepressed beta-lactamase synthesis amongst representative gram-negative bacilli that produce inducible beta-lactamases. both imipenem and cefoxitin were potent inducers of beta-lactamase and were able to antagonize the activity of other beta-lactams against isolates of enterobacter cloacae, citrobacter freundii and ... | 1986 | 3102451 |
| antibacterial properties of imipenem with special reference to the activity against methicillin-resistant staphylococci, cefotaxime-resistant enterobacteriaceae and pseudomonas aeruginosa. | imipenem was examined with standardized agar dilution procedures against a wide range of bacteria. geometric mean mics against the genera escherichia, klebsiella, enterobacter, citrobacter and serratia were 0.1-0.4 mg/l, and proteus and providencia spp. were inhibited by 0.25-4 mg/l. acinetobacter calcoaceticus var. anitratum strains were inhibited by concentrations ranging from 0.12-0.5 mg/l. methicillin-susceptible staphylococci were highly susceptible to the drug (mics: less than or equal to ... | 1986 | 3102452 |
| [comparative studies of antimicrobial agents against causative organisms isolated from urinary tract infections (1984). i. susceptibility distribution]. | our research group was engaged for 3 years (1979-1981) in a study on sensitivities to antibiotics of 4 bacterial groups including representative pathogenic bacteria found in cases of urinary tract infections; i.e. e. coli, klebsiella spp., citrobacter spp., and proteus spp. since 1982, all the bacterial strains isolated by our group from patients with urinary tract infections and deemed by doctors in charge as pathogens were sent to the laboratory of clinical pathology of juntendo university, wh ... | 1986 | 3102808 |
| induction/inhibition of chromosomal beta-lactamases by beta-lactamase inhibitors. | many species of gram-negative bacteria produce chromosomal beta-lactamases that can be induced to high-level expression by exposure to beta-lactam antibiotics. fifty-four strains of escherichia coli, enterobacter, proteus, citrobacter, and morganella were examined for beta-lactamase inducibility by clavulanic acid, sulbactam, ytr 830, ampicillin, and cefoxitin. cefoxitin proved to be the most potent inducer, affecting most of the strains of enterobacter and morganella. clavulanic acid induced 30 ... | 1986 | 3026004 |
| [comparative studies of antimicrobial agents against causative organisms isolated from urinary tract infections (1984). iii. secular changes in susceptibility]. | cases with infections of urinary tracts were divided into 3 groups of the simple infections, and complicated infections without indwelling of catheter, and complicated infections with indwelling of catheter. susceptibilities to antimicrobial agents of escherichia coli, klebsiella spp., proteus spp., citrobacter spp., enterobacter spp., pseudomonas aeruginosa and serratia marcescens which were isolated from patients with these infections were determined. there was no tendency of decline in the su ... | 1986 | 3102809 |
| selection of beta-lactamase producers during cephalosporin and penicillin therapy. | treatment failures due to beta-lactamase producing strains of enterobacter cloacae, proteus vulgaris, citrobacter freundii and pseudomonas aeruginosa are frequently reported. it is difficult, however, to determine the underlying mechanism of resistance development. different beta-lactam drugs, such as cephalosporins and penicillins have different ecological impacts on the infections and physiological flora of patients. they select in different ways although the mutation frequency of strains towa ... | 1986 | 3103207 |