| the epidemiology of pediatric bone and joint infections in cambodia, 2007-11. | there are limited data on osteoarticular infections from resource-limited settings in asia. a retrospective study of patients presenting to the angkor hospital for children, cambodia, january 2007-july 2011, identified 81 cases (28% monoarticular septic arthritis, 51% single-limb osteomyelitis and 15% multisite infections). the incidence was 13.8/100 000 hospital attendances. the median age was 7.3 years, with a male/female ratio of 1.9:1; 35% presented within 5 days of symptom onset (median 7 d ... | 2012 | 22977206 |
| the epidemiology of pediatric bone and joint infections in cambodia, 2007-11. | there are limited data on osteoarticular infections from resource-limited settings in asia. a retrospective study of patients presenting to the angkor hospital for children, cambodia, january 2007-july 2011, identified 81 cases (28% monoarticular septic arthritis, 51% single-limb osteomyelitis and 15% multisite infections). the incidence was 13.8/100 000 hospital attendances. the median age was 7.3 years, with a male/female ratio of 1.9:1; 35% presented within 5 days of symptom onset (median 7 d ... | 2012 | 22977206 |
| childhood osteomyelitis: imaging characteristics. | the purpose of this review is to illustrate the imaging findings of childhood osteomyelitis. the diagnosis of childhood osteomyelitis can be challenging. clinical presentation and laboratory results can differ and are relatively unreliable. to date, its role in the assessment of treatment efficacy is not yet clear. | 2012 | 22875760 |
| actin cross-linking domain of aeromonas hydrophila repeat in toxin a (rtxa) induces host cell rounding and apoptosis. | the repeat in toxin (rtx) of an environmental isolate atcc 7966 of aeromonas hydrophila consists of six genes (rtxachbde) organized in an operon similar to the gene organization found for the rtx of the vibrio species. the first gene in this operon (rtxa) encodes an exotoxin in vibrios, while other genes code for proteins needed for proper activation of rtxa and in secretion of this toxin from vibrio cholerae. however, the rtxa of atcc 7966, as well as from the clinical isolate ssu of a. hydroph ... | 2012 | 22814176 |
| infective endocarditis complicated by aortic graft infection and osteomyelitis: case report and review of literature. | primary aortic graft infection early after aortic graft insertion is well described in the literature. here, we present a unique case of late aortic graft infection 5 years after insertion secondary to mitral valve endocarditis, resulting from cellulitis in a patient with severe venous varicosities. a 63-year-old male presented for severe low back pain, constipation, and low-grade fever. an abdominal computed tomography scan with oral and intravenous contrast showed a normal spine and urinary tr ... | 2012 | 22866008 |
| clinical characteristics and thrombolytic outcomes of infective endocarditis-associated stroke. | our aim was to describe the clinical features of infective endocarditis (ie) in the acute stroke setting and outcomes following thrombolytic therapy. | 2012 | 23983869 |
| multilocus sequence typing and rtxa toxin gene sequencing analysis of kingella kingae isolates demonstrates genetic diversity and international clones. | kingella kingae, a normal component of the upper respiratory flora, is being increasingly recognized as an important invasive pathogen in young children. genetic diversity of this species has not been studied. | 2012 | 22693588 |
| acute endocarditis in intravenous drug users: a case report and literature review. | infective endocarditis (ie) is a notorious complication of intravenous drug use (idu). it typically affects the cardiac valves. among these, the tricuspid is the most common affected valve, although the mitral and/or aortic valves can also be involved. methicillin sensitive staphylococcus aureus (mssa) is the most common etiological microbial agent of ie in idu. once ie is diagnosed, antibiotic treatment should start immediately after blood cultures have been obtained. however, ie in this partic ... | 2012 | 23882351 |
| dual priming oligonucleotides for broad-range amplification of the bacterial 16s rrna gene directly from human clinical specimens. | broad-range amplification and sequencing of the bacterial 16s rrna gene directly from clinical specimens are offered as a diagnostic service in many laboratories. one major pitfall is primer cross-reactivity with human dna which will result in mixed chromatograms. mixed chromatograms will complicate subsequent sequence analysis and impede identification. in sybr green real-time pcr assays, it can also affect crossing threshold values and consequently the status of a specimen as positive or negat ... | 2012 | 22278843 |
| infective endocarditis by aggregatibacter paraphrophilus: case report and literature review. | aggregatibacter paraphrophilus (former name, haemophilus paraphrophilus) is a normal inhabitant of the naso- and oropharynx and has been rarely reported as a cause of human infections. a case of infective endocarditis by this organism is being reported and literature of endocarditis cases caused by aggregatibacter paraphrophilus is being reviewed. | 2013 | 24392406 |
| reply to the letter to the editor: another look: is there a flaw to current hip septic arthritis diagnostic algorithms? | | 2013 | 24146359 |
| reply to the letter to the editor: another look: is there a flaw to current hip septic arthritis diagnostic algorithms? | | 2013 | 24146359 |
| letter to the editor: another look: is there a flaw to current hip septic arthritis diagnostic algorithms? | | 2013 | 24136809 |
| letter to the editor: another look: is there a flaw to current hip septic arthritis diagnostic algorithms? | | 2013 | 24136809 |
| incidence, risk factors and prediction of post-operative acute kidney injury following cardiac surgery for active infective endocarditis: an observational study. | cardiac surgery is frequently needed in patients with infective endocarditis (ie). acute kidney injury (aki) often complicates ie and is associated with poor outcomes. the purpose of the study was to determine the risk factors for post-operative aki in patients operated on for ie. | 2013 | 24093498 |
| two atypical cases of kingella kingae invasive infection with concomitant human rhinovirus infection. | we describe two atypical cases of kingella kingae infection in children diagnosed by pcr, one case involving a soft tissue abscess and one case a femoral brodie abscess. both patients had concomitant human rhinovirus infection. k. kingae strains, isolated from an oropharyngeal swab, were characterized by multilocus sequence typing and rtxa sequencing. | 2013 | 23784119 |
| repeated serum alkaline phosphatase measurements in the treatment of childhood acute bone and joint infections with high doses of antibiotics. | | 2013 | 24003432 |
| a pediatric case of cardiobacterium hominis endocarditis. | gram negative endocarditis is relatively rare in pediatrics but when they occur they are most frequently caused by one of the hacek (haemophilus species, actinobacillus actinomycetemcomitans, c. hominis, eikenella corrodens and kingella kingae) group of microorganisms. within the hacek group of microorganisms there have been approximately 100 cases of cardiobacterium hominis endocarditis reported in the literature, but only 2 previous cases of endocarditis and one case of pericarditis have been ... | 2013 | 24470958 |
| prosthetic valve endocarditis and bloodstream infection due to mycobacterium chimaera. | prosthetic valve endocarditis (pve) due to fast-growing nontuberculous mycobacteria (ntm) has been reported anecdotally. reports of pve with slowly growing ntm, however, are lacking. we present here one case of pve and one case of bloodstream infection caused by mycobacterium chimaera. randomly amplified polymorphic dna (rapd)-pcr indicated a relatedness of the two m. chimaera strains. both patients had heart surgery 2 years apart from each other. a nosocomial link was not detected. | 2013 | 23536407 |
| septic arthritis caused by noncapsulated haemophilus influenzae. | since the introduction of type b haemophilus influenzae vaccination, noncapsulated h. influenzae has become responsible for most cases of invasive h. influenzae diseases. in our two cases of septic arthritis, we isolated strains with β-lactamase-positive amoxicillin-clavulanate resistance (blpacr). thus, the increasing prevalence of blpacr should be taken into account when empirical therapy is chosen for septic arthritis. | 2013 | 23515545 |
| hacek-induced endocarditis. | a 61-year-old patient with diabetes had a bio-prosthetic aortic valve replacement 3 years before admission. he complained of lethargy, night sweats, decreased appetite and erratic blood glucose with no weight loss. he had splinter haemorrhage and a systolic ejection murmur at the aortic area. chest and abdominal examination revealed no abnormality. the erythrocyte sedimentation rate and c reactive protein were raised. he had several sets of blood cultures and he was started on empirical vancomyc ... | 2013 | 23682079 |
| antibiofilm activity of actinobacillus pleuropneumoniae serotype 5 capsular polysaccharide. | cell-free extracts isolated from colony biofilms of actinobacillus pleuropneumoniae serotype 5 were found to inhibit biofilm formation by staphylococcus aureus, s. epidermidis and aggregatibacter actinomycetemcomitans, but not by a. pleuropneumoniae serotype 5 itself, in a 96-well microtiter plate assay. physical and chemical analyses indicated that the antibiofilm activity in the extract was due to high-molecular-weight polysaccharide. extracts isolated from a mutant strain deficient in the pro ... | 2013 | 23691104 |
| a case of kingella kingae endocarditis complicated by native mitral valve rupture. | we report a case of kingella kingae endocarditis in a patient with a history of recent respiratory tract infection and dental extraction. this case is remarkable for embolic and vasculitic phenomena in association with a large valve vegetation and valve perforation. kingella kingae is an organism known to cause endocarditis, however early major complications are uncommon. our case of kingella endocarditis behaved in a virulent fashion necessitating a combined approach of intravenous antibiotic t ... | 2013 | 23671460 |
| antimicrobial susceptibilities of clinical isolates of hacek organisms. | the "hacek" organisms are a group of fastidious gram-negative bacteria that cause a variety of infections, including infective endocarditis. antimicrobial susceptibility testing is not universally available, and therapy for these infections is often empirical. we report the antimicrobial susceptibilities of 70 clinical hacek isolates to 18 antimicrobials. all isolates were susceptible to ceftriaxone and levofloxacin, indicating that these agents remain appropriate empirical choices for the treat ... | 2013 | 23403420 |
| infective endocarditis developing serious multiple complications. | a 20-year-old female patient with no history of heart disease presented to the hospital with high fever, cough and sputum. on the third day of hospitalisation, left facial paralysis developed and cranial revealed an infarct in the right frontoparietotemporal lobe. transthoracic echocardiography revealed 1.5 × 2 cm-sized vegetation on the mitral valve and severe mitral regurgitation. on the 11th day of hospitalisation, multiple emboli were shown to be present in the left iliac artery. since the p ... | 2013 | 23362066 |
| construction of new cloning, lacz reporter and scarless-markerless suicide vectors for genetic studies in aggregatibacter actinomycetemcomitans. | to elucidate the putative function of a gene, effective tools are required for genetic characterization that facilitate its inactivation, deletion or modification on the bacterial chromosome. in the present study, the nucleotide sequence of the escherichia coli/aggregatibacter actinomycetemcomitans shuttle vector pygk was determined, allowing us to redesign and construct a new shuttle cloning vector, pjt4, and promoterless lacz transcriptional/translational fusion plasmids, pjt3 and pjt5. plasmi ... | 2013 | 23353051 |
| first human systemic infection caused by spiroplasma. | spiroplasma species are organisms that normally colonize plants and insects. we describe the first case of human systemic infection caused by spiroplasma bacteria in a patient with hypogammaglobulinemia undergoing treatment with biological disease-modifying antirheumatic agents. spiroplasma turonicum was identified through molecular methods in several blood cultures. the infection was successfully treated with doxycycline plus levofloxacin. | 2014 | 25428150 |
| first human systemic infection caused by spiroplasma. | spiroplasma species are organisms that normally colonize plants and insects. we describe the first case of human systemic infection caused by spiroplasma bacteria in a patient with hypogammaglobulinemia undergoing treatment with biological disease-modifying antirheumatic agents. spiroplasma turonicum was identified through molecular methods in several blood cultures. the infection was successfully treated with doxycycline plus levofloxacin. | 2014 | 25428150 |
| kingella kingae kk247, an atypical pulsed-field gel electrophoresis clone a strain. | kingella kingae strain kk247 was isolated from an adult israeli patient with endocarditis. it belongs to pulsed-field gel electrophoresis clone a, has a 2,113,021-bp genome, a 15,507-bp plasmid that carries genes encoding β-lactamases, and possesses 45 transposases, compared to the 5 detected in other k. kingae strains. | 2014 | 25428974 |
| a rare pathogen for subacute osteomyelitis in adolescent: serratia marcescens. | there are various pathogens reported for osteomyelitis. osteomyelitis is bone infection which produces pain and fever, also threatens bone instability. it can lead to nonunion. the purpose of this report was to describe a case with union delay of the tibia due to serratia marcescens osteomyelitis. serratia marcescens is an unexpected pathogen for subacute osteomyelitis in adolescence. because of difficulty of diagnosis, treatment can be delayed or the situation can cause complications like nonun ... | 2014 | 25704404 |
| a rare pathogen for subacute osteomyelitis in adolescent: serratia marcescens. | there are various pathogens reported for osteomyelitis. osteomyelitis is bone infection which produces pain and fever, also threatens bone instability. it can lead to nonunion. the purpose of this report was to describe a case with union delay of the tibia due to serratia marcescens osteomyelitis. serratia marcescens is an unexpected pathogen for subacute osteomyelitis in adolescence. because of difficulty of diagnosis, treatment can be delayed or the situation can cause complications like nonun ... | 2014 | 25704404 |
| major intercontinentally distributed sequence types of kingella kingae and development of a rapid molecular typing tool. | although kingella kingae is the most common etiology of osteoarticular infections in young children, is a frequent cause of bacteremia in those younger than 4 years, and has been involved in clusters of invasive infections among daycare center attendees, the population structure of the species has not been systematically studied. using multilocus sequence typing, we investigated the genetic diversity of the largest intercontinental collection of k. kingae strains to date. to facilitate typing of ... | 2014 | 25143574 |
| chondrosternal arthritis in infant: an unusual entity. | primary arthritis of chondrosternal joint is very rare and occurs in infants less than 18 months of age. presentation is most often subacute but may be acute. child presents with a parasternal mass with history of fever and/or local signs of infection. clinical symptoms vary from a painless noninflammatory to a painful mass with local tenderness and swelling, while fever may be absent. laboratory data show low or marginally raised levels of white blood cells and c-reactive protein, reflecting, r ... | 2014 | 25386377 |
| first identification of a chromosomally located penicillinase gene in kingella kingae species isolated in continental europe. | kingella kingae is the major pathogen causing osteoarticular infections (oai) in young children in numerous countries. plasmid-borne tem-1 penicillinase production has been sporadically detected in a few countries but not in continental europe, despite a high prevalence of k. kingae infections. we describe here for the first time a k. kingae β-lactamase-producing strain in continental europe and demonstrate the novel chromosomal location of the blatem-1 gene in k. kingae species. | 2014 | 25049250 |
| lactobacillus endocarditis with prosthetic material: a case report on non-surgical management with corresponding literature review. | lactobacilli are rod shaped gram positive bacteria that naturally colonize the human gastrointestinal and genitourinary tracts and occasionally cause disease in humans. lactobacillus infections are found in patients who are immunocompromized or have severe comorbidities. we report lactobacillus endocarditis in a 17-year-old adolescent girl with cardiac prosthetic material following surgical correction for complex cyanotic congenital heart disease. accurate identification of the organism can be d ... | 2014 | 25276330 |
| anti-biofilm activity: a function of klebsiella pneumoniae capsular polysaccharide. | competition and cooperation phenomena occur within highly interactive biofilm communities and several non-biocides molecules produced by microorganisms have been described as impairing biofilm formation. in this study, we investigated the anti-biofilm capacities of an ubiquitous and biofilm producing bacterium, klebsiella pneumoniae. cell-free supernatant from k. pneumoniae planktonic cultures showed anti-biofilm effects on most gram positive bacteria tested but also encompassed some gram negati ... | 2014 | 24932475 |
| rtx toxin plays a key role in kingella kingae virulence in an infant rat model. | kingella kingae is a human oral bacterium that can cause diseases of the skeletal system in children and infective endocarditis in children and adults. k. kingae produces a toxin of the rtx group, rtxa. to investigate the role of rtxa in disease pathogenesis in vivo, k. kingae strain pykk081 and its isogenic rtxa-deficient strain kknb100 were tested for their virulence and pathological consequences upon intraperitoneal injections in 7-day-postnatal (pn 7) rats. at the doses above 8.0 × 10(6) cel ... | 2014 | 24664507 |
| clinical features of right-sided infective endocarditis occurring in non-drug users. | right-sided infective endocarditis (rie) occurs predominantly in intravenous drug users in western countries, and it has a relatively good prognosis. clinical features and prognosis of rie occurring in non-drug users are not well known. we investigated the clinical findings of rie in non-drug users. we retrospectively reviewed 345 cases diagnosed with ie. cases with rie or left-sided infective endocarditis (lie) defined by the vegetation site were included and cases having no vegetation or both- ... | 2014 | 24932077 |
| predicting the occurrence of embolic events: an analysis of 1456 episodes of infective endocarditis from the italian study on endocarditis (sei). | embolic events are a major cause of morbidity and mortality in patients with infective endocarditis. we analyzed the database of the prospective cohort study sei in order to identify factors associated with the occurrence of embolic events and to develop a scoring system for the assessment of the risk of embolism. | 2014 | 24779617 |
| cardiobacterium hominis-induced acute dacryocystitis and lacrimal abscess. | cardiobacterium hominis is a member of the hacek (haemophilus sp., actinobacillus actinomycetemcomitans, c. hominis, eikenella corrodens, and kingella kingae) group commonly associated with endocarditits and is normally present in the respiratory tract. we describe the first case of acute dacryocystitis with lacrimal abscess caused by c. hominis along with a brief review of the literature. the patient responded to oral and topical ciprofloxacin after incision and drainage and awaits dacryocystor ... | 2014 | 24008805 |
| surgical treatment of infective endocarditis in active intravenous drug users: a justified procedure? | infective endocarditis is a life threatening complication of intravenous drug abuse, which continues to be a major burden with inadequately characterised long-term outcomes. we reviewed our institutional experience of surgical treatment of infective endocarditis in active intravenous drug abusers with the aim of identifying the determinants long-term outcome of this distinct subgroup of infective endocarditis patients. | 2014 | 24661344 |
| kingella kingae septic arthritis in children: recognising an elusive pathogen. | kingella kingae is an increasingly identified cause of musculoskeletal infections in young children. we report our experience with a recently developed polymerase chain reaction (pcr) method and review the clinical course of children diagnosed with k. kingae septic arthritis in a tertiary referral paediatric hospital. | 2014 | 24488842 |
| case 2: a toddler with hyperlordosis. | | 2015 | 26744565 |
| paediatric musculoskeletal interventional radiology. | interventional radiology technique is now well established and widely used in the adult population. through minimally invasive procedures, it increasingly replaces surgical interventions that involve higher percentages of invasiveness and, consequently, of morbidity and mortality. for these advantageous reasons, interventional radiology in recent years has spread to the paediatric age as well. the aim of this study was to review the literature on the development, use and perspectives of these pr ... | 2015 | 26235144 |
| paediatric musculoskeletal interventional radiology. | interventional radiology technique is now well established and widely used in the adult population. through minimally invasive procedures, it increasingly replaces surgical interventions that involve higher percentages of invasiveness and, consequently, of morbidity and mortality. for these advantageous reasons, interventional radiology in recent years has spread to the paediatric age as well. the aim of this study was to review the literature on the development, use and perspectives of these pr ... | 2015 | 26235144 |
| epidemiology and the prognosis of healthcare-associated infective endocarditis in china: the significance of non-nosocomial acquisition. | limited research has been conducted on healthcare-associated infective endocarditis (haie), although it is of increasing importance. the aim of this study is to compare the epidemiology, clinical characteristics, and prognosis of community-acquired ie (ca-ie) with haie and non-nosocomial healthcare-associated ie (nnhca-ie). a retrospective, consecutive case-series analysis was organized and performed during the 20-year study period in huashan hospital, shanghai, china. a total of 154 patients we ... | 2015 | 26251828 |
| identification of a conserved linear b-cell epitope of streptococcus dysgalactiae gapc protein by screening phage-displayed random peptide library. | the gapc of streptococcus dysgalactiae (s. dysgalactiae) is a highly conserved surface protein that can induce protective humoral immune response in animals. however, b-cell epitopes on the s. dysgalactiae gapc have not been well identified. in this study, a monoclonal antibody (mab5b7) against the gapc1-150 protein was prepared. after passive transfer, mab5b7 could partially protect mice against s. dysgalactiae infection. eleven positive phage clones recognized by mab5b7 were identified by scre ... | 2015 | 26121648 |
| kingella kingae causing septic arthritis of the knee in an immunocompetent adult. | the bacterium kingella kingae is a species of gram-negative coccobacillus usually found in the oropharynx. this is an emerging pathogen reported to cause bacteraemia, endocarditis, and osteoarticular infections in children and endocarditis in the immunocompromised adult. however, there are few cases of isolated joint infections reported in the immunocompetent adult. due to specific isolation techniques required, delay in diagnosis can compromise patient outcome. we report a rare case of septic a ... | 2015 | 26199777 |
| staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management. | staphylococcus aureus is a major human pathogen that causes a wide range of clinical infections. it is a leading cause of bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device-related infections. this review comprehensively covers the epidemiology, pathophysiology, clinical manifestations, and management of each of these clinical entities. the past 2 decades have witnessed two clear shifts in the epidemiology of s. aureus infections: f ... | 2015 | 26016486 |
| septic cerebral embolisation in fulminant mitral valve infective endocarditis. | a 37-year-old male with known intravenous drug use was admitted with an acute onset of worsening confusion and speech impairment. his vitals and biochemical profile demonstrated severe sepsis, with a brain ct showing several lesions suspicious for cerebral emboli. he then went on to have a bedside transthoracic echocardiogram that was positive for vegetation on the mitral valve, with associated severe mitral regurgitation. unfortunately, before he was stable enough to be transferred for valve su ... | 2015 | 26120312 |
| concomitant septic arthritis and osteomyelitis of the hip in young children; a new pathophysiological hypothesis suggested by mri enhancement pattern. | in children, septic arthritis (sa) of the hip is either primary or concomitant with acute haematogenous osteomyelitis (aho). however, seldom, patients with isolated sa at presentation, may later show osteomyelitis in the metaphysis. the aim of this study was to elaborate a physiopathological hypothesis based on the peculiar mri findings to explain the onset of aho after sa. | 2015 | 25986395 |
| polyarticular septic arthritis caused by haemophilus influenzae serotype f in an 8-month-old immunocompetent infant: a case report and review of the literature. | background. the standard use of vaccinations against pathogens has resulted in a decreased incidence of musculoskeletal infections caused by these previously common bacterial pathogens. consequently, the incidence of infections caused by atypical bacteria is rising. this report presents a case of septic arthritis caused by non-type b h. influenzae in a pediatric patient. methods. we report a case of an infant with polyarticular septic arthritis caused by h. influenzae serotype f. a literature re ... | 2015 | 26064739 |
| clinical evaluation of commercial nucleic acid amplification tests in patients with suspected sepsis. | sepsis is a serious medical condition requiring timely administered, appropriate antibiotic therapy. blood culture is regarded as the gold standard for aetiological diagnosis of sepsis, but it suffers from low sensitivity and long turnaround time. thus, nucleic acid amplification tests (naats) have emerged to shorten the time to identification of causative microbes. the aim of the present study was to evaluate the clinical utility in everyday practice in the emergency department of two commercia ... | 2015 | 25928122 |
| pore forming activity of the potent rtx-toxin produced by pediatric pathogen kingella kingae: characterization and comparison to other rtx-family members. | pediatric septic arthritis in patients under age of four is frequently caused by the oral gram-negative bacterium kingella kingae. this organism may be responsible for a severe form of infective endocarditis in otherwise healthy children and adults. a major virulence factor of k. kingae is rtxa, a toxin that belongs to the rtx (repeats-in-toxin) group of secreted pore forming toxins. to understand the rtxa effects on host cell membranes, the toxin activity was studied using planar lipid bilayers ... | 2015 | 25858109 |
| nontuberculous mycobacteria: an underestimated cause of bioprosthetic valve infective endocarditis. | background. atypical mycobacteria, or nontuberculous mycobacteria (ntm), have been barely reported as infective endocarditis (ie) agents. methods. from january 2010 to december 2013, cardiac valve samples sent to our laboratory as cases of blood culture-negative suspected ie were analyzed by 16s rdna polymerase chain reaction (pcr). when positive for ntm, hsp pcr allowed species identification. demographic, clinical, echocardiographic, histopathological, and ziehl-neelsen staining data were th ... | 2015 | 26213691 |
| a rare case of clavicle osteomyelitis in a child and literature review. | acute clavicle osteomyelitis in children is rare representing <3% of osteomyelitis cases. we treated a 12-year-old boy who presented with acute pain in the right clavicle and high fever for 4 days. mri showed abnormal signal in the right clavicle with periosteal reaction. staphylococcus aureus isolated from blood was susceptible to methicillin, clindamycin, and macrolides. clindamycin was given intravenously for 3 wks and orally for another 3 wks with no recurrence. we reviewed clavicle osteomye ... | 2016 | 28050301 |
| ischemic stroke and septic shock after subacute endocarditis caused by haemophilus parainfluenzae: case report. | haemophilus parainfluenzae, which belongs to the hacek (haemophilus ssp, actinobacillus actinomycetemcomitans, cardiobacterium hominis, eikenella corrodens, and kingella kingae) group, is a rare cause of subacute endocarditis and may lead to ischemic stroke. a 65-year-old female patient previously diagnosed with rheumatic valve disease was submitted to surgical mitral valve repair in 1996. physical examination did not reveal any murmurs; physical examination of the lungs and abdomen was normal. ... | 2016 | 27924179 |
| ischemic stroke and septic shock after subacute endocarditis caused by haemophilus parainfluenzae: case report. | haemophilus parainfluenzae, which belongs to the hacek (haemophilus ssp, actinobacillus actinomycetemcomitans, cardiobacterium hominis, eikenella corrodens, and kingella kingae) group, is a rare cause of subacute endocarditis and may lead to ischemic stroke. a 65-year-old female patient previously diagnosed with rheumatic valve disease was submitted to surgical mitral valve repair in 1996. physical examination did not reveal any murmurs; physical examination of the lungs and abdomen was normal. ... | 2016 | 27924179 |
| cardiac implantable electronic device infection due to mycobacterium species: a case report and review of the literature. | infection of cardiac implantable electronic devices is a serious cardiovascular disease and it is associated with a high mortality. mycobacterium species may rarely cause cardiac implantable electronic devices infection. | 2016 | 27553460 |
| transitioning antimicrobials from intravenous to oral in pediatric acute uncomplicated osteomyelitis. | osteomyelitis is a bone infection that requires prolonged antibiotic treatment and potential surgical intervention. if left untreated, acute osteomyelitis can lead to chronic osteomyelitis and overwhelming sepsis. early treatment is necessary to prevent complications, and the standard of care is progressing to a shorter duration of intravenous (iv) antibiotics and transitioning to oral therapy for the rest of the treatment course. we systematically reviewed the current literature on pediatric pa ... | 2016 | 27610339 |
| mature biofilm degradation by potential probiotics: aggregatibacter actinomycetemcomitans versus lactobacillus spp. | the biofilm degradation of aggregatibacter actinomycetemcomitans is essential as a complete periodontal disease therapy, and here we show the effects of potential probiotic bacteria such as lactobacillus spp. for the biofilm of several serotypes of a. actinomycetemcomitans strains. eight of the 13 species showed the competent biofilm degradation of ≥ 90% reduction in biofilm values in a. actinomycetemcomitans y4 (serotype b) as well as four of the seven species for the biofilm of a. actinomycete ... | 2016 | 27438340 |
| a case report of severely damaged hip joint caused by sapho syndrome treated with 2-stage total hip arthroplasty. | synovitis, acne, pustulosis, hyperostosis, and osteitis (sapho) syndrome is an increasingly recognized entity. the hip joint is known as a less frequently affected site in sapho syndrome, and there has been limited reports about hip joint diseases caused by sapho syndrome, and as such adequate treatment for this disease spectrum is still not fully elucidated. | 2016 | 27399138 |
| detection of bacterial pathogens in synovial and pleural fluid with the filmarray blood culture identification system. | we report the use of filmarray blood culture identification (bcid) multiplex pcr system for pathogen detection from a child with septic arthritis that streptococcus pyogenes was identified directly from synovial fluid and a child with complicated pneumonia with pleural effusion that streptococcus pneumoniae was identified from pleural fluid. | 2016 | 27419071 |
| update on the management of pediatric acute osteomyelitis and septic arthritis. | acute osteomyelitis and septic arthritis are two infections whose frequencies are increasing in pediatric patients. acute osteomyelitis and septic arthritis need to be carefully assessed, diagnosed, and treated to avoid devastating sequelae. traditionally, the treatment of acute osteoarticular infection in pediatrics was based on prolonged intravenous anti-infective therapy. however, results from clinical trials have suggested that in uncomplicated cases, a short course of a few days of parenter ... | 2016 | 27258258 |
| a case of acute osteomyelitis: an update on diagnosis and treatment. | osteomyelitis in children is a serious disease in children requiring early diagnosis and treatment to minimize the risk of sequelae. therefore, it is of primary importance to recognize the signs and symptoms at the onset and to properly use the available diagnostic tools. it is important to maintain a high index of suspicion and be aware of the evolving epidemiology and of the emergence of antibiotic resistant and aggressive strains requiring careful monitoring and targeted therapy. hereby we pr ... | 2016 | 27240392 |
| pediatric clinical microbiology: it's the little things. | | 2016 | 27076655 |
| primary subacute hematogenous osteomyelitis in children: a clearer bacteriological etiology. | this study aimed to describe the spectrum of pediatric primary subacute hematogenous osteomyelitis (psaho) and to investigate its bacterial etiology. | 2016 | 27174185 |
| laboratory predictors for risk of revision surgery in pediatric septic arthritis. | reported complications of pediatric septic arthritis range from minor growth abnormalities to potentially life-threatening conditions and death; some children require multiple surgeries for eradication of infection. the purpose of this study is: (1) to determine the failure rate of a single surgical incision and drainage (i&d) in pediatric septic arthritis, (2) to identify risk factors for failure which are detectable at the time of initial presentation, and (3) to trend post-operative c-reactiv ... | 2016 | 27174186 |
| bacillus pumilus septic arthritis in a healthy child. | we report a case of septic arthritis caused by a bacillus species, b. pumilus, occurring in a healthy child. this organism rarely causes serious infections and has only been described in newborns and immunocompromised individuals or as a skin infection. this child developed an indolent joint swelling after a minor skin injury, and symptoms were initially thought most consistent with chronic arthritis. the case demonstrates that clinicians should consider joint infection in children presenting wi ... | 2016 | 27366165 |
| infectious discitis and spondylodiscitis in children. | in children, infectious discitis (d) and infectious spondylodiscitis (sd) are rare diseases that can cause significant clinical problems, including spinal deformities and segmental instabilities. moreover, when the infection spreads into the spinal channel, d and sd can cause devastating neurologic complications. early diagnosis and treatment may reduce these risks. the main aim of this paper is to discuss recent concepts regarding the epidemiology, microbiology, clinical presentation, diagnosis ... | 2016 | 27070599 |
| advantages and limitations of direct pcr amplification of bacterial 16s-rdna from resected heart tissue or swabs followed by direct sequencing for diagnosing infective endocarditis: a retrospective analysis in the routine clinical setting. | infective endocarditis (ie) is a life-threatening disease that is associated with high morbidity and mortality. its long-term prognosis strongly depends on a timely and optimized antibiotic treatment. therefore, identification of the causative pathogen is crucial and currently based on blood cultures followed by characterization and susceptibility testing of the isolate. however, antibiotic treatment starting prior to blood sampling or ie caused by fastidious or intracellular microorganisms may ... | 2016 | 27110570 |
| polymerase chain reaction detection of kingella kingae in children with culture-negative septic arthritis in eastern ontario. | the bacterium kingella kingae may be an under-recognized cause of septic arthritis in canadian children because it is difficult to grow in culture and best detected using molecular methods. | 2016 | 27095882 |
| the brief case: kingella kingae septic arthritis in a 14-month-old child. | | 2016 | 26917458 |
| inner-membrane protein morc is involved in fimbriae production and biofilm formation in aggregatibacter actinomycetemcomitans. | fimbrial subunit synthesis, secretion and assembly on the surface of the periodontal pathogen aggregatibacter actinomycetemcomitans are essential for biofilm formation. a recent quantitative proteomics study employing an afimbriated strain and a developed mutant isogenic for the inner-membrane protein morphogenesis protein c (morc) revealed that the abundance of the proteins of the fimbrial secretion apparatus in the membrane is dependent on morc. to investigate further the relationship between ... | 2016 | 26796329 |
| hacek endocarditis: a review. | the hacek group, referring to haemophilus spp., aggregatibacter actinomycetemcomitans, cardiobacterium hominis, eikenella corrodens, and kingella kingae, is a rare cause of infective endocarditis (ie). it causes the majority of gram-negative endocarditis cases and has an excellent prognosis and simple management if properly identified. however, delay in diagnosis and associated complications can render the infection fatal. | 2016 | 27124204 |
| recurrent infective endocarditis due to aggregatibacter aphrophilus and staphylococcus lugdunensis. | uncommon microorganisms are increasingly being recognized as causative agents of paediatric infectious endocarditis (ie). we report a 4-year old girl with congenital heart disease, who suffered from 2 ie episodes secondary to aggregatibacter aphrophilus (formerly haemophilus aphrophilus) and staphylococcus lugdunensis, both rarely reported pathogens in this age group. the patient was initially successfully treated with prolonged intravenous antibiotic courses, however removal of the contegra val ... | 2015 | 25751682 |
| pleuritis due to brevundimonas diminuta in a previously healthy man. | brevundimonas diminuta is rarely associated with invasive infections. we report the case of a previously healthy young man with pleural effusion, in which b. diminuta was recovered but incorrectly identified as kingella kingae when it was freshly isolated. consequently, the misidentification resulted in initial treatment failure. the correct identification was achieved through further incubation, sequencing of the 16s rrna gene and ms. | 2013 | 23180480 |
| high rates of complications following kingella kingae infective endocarditis in children: a case series and review of the literature. | kingella kingae is part of the haemophilus spp., aggregatibacter spp., cardiobacterium hominis, eikenella corrodens and kingella spp. organisms that are known to cause bacterial endocarditis. evidence suggests it is also a common pharyngeal colonizer in children <2 years of age. we reviewed the literature to determine common complications of k. kingae infective endocarditis in children. | 2014 | 24921624 |
| an outbreak of kingella kingae infections associated with hand, foot and mouth disease/herpangina virus outbreak in marseille, france, 2013. | outbreaks of invasive kingella kingae infections recently emerged as a new public health concern in daycare centers in europe, usa and israel. despite this, no trigger factor has been yet identified, preventing the setting up of rational measures of control and prevention. we report an outbreak of k. kingae infections associated with hand, foot and mouth disease/herpangina outbreak, and we define the research and policy priorities. | 2015 | 25742075 |
| low prevalence of kingella kingae carriage in children aged 6-48 months in sydney, australia. | a prospective observational study was conducted to estimate the prevalence of oropharyngeal carriage of kingella kingae in healthy australian pre-school children. | 2017 | 27669685 |
| clinical presentation and treatment of septic arthritis in children. | the aim of this study is to determine the epidemiological features, clinical presentation, and treatment of children with septic arthritis. | 2017 | 28373088 |
| the type a and type b polysaccharide capsules predominate in an international collection of invasive kingella kingae isolates. | kingella kingae is an encapsulated gram-negative bacterium and an important etiology of osteoarticular infections in young children. a recent study examining a diverse collection of carrier and invasive k. kingae isolates from israel revealed four distinct polysaccharide capsule types. in this study, to obtain a global view of k. kingae capsule type diversity, we examined an international collection of isolates using a multiplex pcr approach. the collection contained all four previously identifi ... | 2017 | 28317027 |
| an outbreak of kingella kingae infections complicating a severe hand, foot, and mouth disease outbreak in nice, france, 2016. | we report the investigative methods for the diagnosis of an epidemic and culture-negative k. kingae endocarditis complicating a severe outbreak of hand, foot, and mouth disease in a childcare center. the diagnosis was confirmed by pcr testings performed from cardiac tissue. our findings argue for the systematic investigation of k. kingae outbreaks by using molecular tools in such context. | 2016 | 28002358 |
| kingella kingae chest mass mimicking a tumor in an 11-month-old baby. | kingella kingae has been recognized as a common etiology of pediatric osteoarticular infections, especially among children younger than 5 years of age. in recent years, there have been reported cases of unusual manifestations. we report a rare case of a chest mass mimicking a tumor in an 11-month-old baby. | 2017 | 27956728 |
| kingella kingae microbial keratitis in a human immunodeficiency virus patient with orthokeratology lens wear. | | 2016 | 27943526 |
| outbreaks of invasive kingella kingae infections in daycare facilities: approach to investigation and management. | | 2017 | 27939255 |
| [treatment and progression of acute communautary osteoarticular infections in healthy children: a retrospective monocentric study of 64 patients]. | the prognosis of osteoarticular infections has improved over the past 20 years but it still remains potentially severe. the treatment of these infections has been simplified and shortened. in 2008, the pediatric infectious disease group (gpip) established new therapeutic guidelines in order to standardize treatment in france. the aim of this study is to analyze practices in a parisian hospital and assess the efficacy of this treatment in short and medium terms. | 2016 | 27745829 |
| unusual case of paediatric septic arthritis of the lumbar facet joints due to kingella kingae. | a 32-month-old boy presented with febrile limping that had developed over 6days, associated with right lumbosacral inflammatory swelling. magnetic resonance imaging (mri) showed joint effusion of the right l5-s1 zygapophyseal joint, complicated by destructive osteomyelitis of the l5 articular process and paraspinal abscess. surgery was decided to evacuate the fluid accumulation and rule out differential diagnoses. the diagnosis of septic arthritis of the facet joint was confirmed intraoperativel ... | 2016 | 27639784 |
| in vitro characterization of biofilms formed by kingella kingae. | the gram-negative bacterium kingella kingae is part of the normal oropharyngeal mucosal flora of children <4 years old. k. kingae can enter the submucosa and cause infections of the skeletal system in children, including septic arthritis and osteomyelitis. the organism is also associated with infective endocarditis in children and adults. although biofilm formation has been coupled with pharyngeal colonization, osteoarticular infections, and infective endocarditis, no studies have investigated b ... | 2016 | 27714987 |
| high rate of oropharyngeal kingella kingae carriage in new zealand children. | this study aimed to describe the burden of disease and estimated rates of oropharyngeal carriage of kingella kingae among new zealand children. we compared polymerase chain reaction (pcr) and culture for the detection of this microorganism with a view to further development and implementation of k. kingae pcr in christchurch hospital. | 2016 | 27586302 |
| epidemiology and management of acute, uncomplicated septic arthritis and osteomyelitis: spanish multicenter study. | acute osteoarticular infection (oai) is a potentially severe disease. the aim of this study was to evaluate the etiology, clinical characteristics and therapeutic approach of oai in children in spain. | 2016 | 27455444 |
| identifying reservoirs of infections caused by kingella kingae: a case-control study of oropharyngeal carriage of k. kingae among healthy adults. | kingella kingae is currently recognized as a significant pathogen of the pediatric population. nevertheless, the possibility for adults to serve as a reservoir of healthy carriers has not been studied. | 2016 | 27420804 |
| spinal infections in children: a review. | spinal infections are uncommon but significant causes of morbidity and hospitalization in the paediatric population. these infections encompass a broad range of conditions, from discitis to osteomyelitis and spinal epidural and intramedullary abscesses. paediatric spinal infections can be caused by a range of bacterial, viral, fungal and parasitic agents. ultrastructural differences of the vertebrae and associated structures result in distinct mechanisms of pathogenesis of spinal infections in c ... | 2016 | 27408498 |
| subacute osteomyelitis by kingella kingae in a 5-year-old boy after chickenpox infection. | | 2016 | 27277204 |
| current data on acute haematogenous osteomyelitis in children in southern israel: epidemiology, microbiology, clinics and therapeutic consequences. | acute haematogenous osteomyelities (aho) is the most common form of osteomyelitis, occurring when bone is infected secondary to transient bacteremia. the prevalence, aetiology and outcome of aho may vary from region to region and period to period. the study objectives were to define the epidemiology, clinical, laboratory and imaging characteristics and treatment consequences of aho in children in southern israel. | 2016 | 27169533 |
| uncommon kingella kingae lytic bone lesions in children. | | 2016 | 26946080 |
| kingella kingae-associated pediatric osteoarticular infections: an overview of 566 reported cases. | this study aimed to summarize clinical experience with kingella kingae-associated pediatric osteoarticular infections (oais). we reviewed 566 cases in the english literature from 2000 to june 2014. more than 80% of the patients were diagnosed between 4 months and 4 years of age, and the male to female ratio was 1.14:1. the most frequent preceding illness was upper respiratory tract infections (82%). the top 3 oais types were septic arthritis (73.1%), osteomyelitis (15.7%), and spondylodiscitis ( ... | 2016 | 26869328 |
| epidemiologic and microbiologic characteristics of occult bacteremia among febrile children in southern israel, before and after initiation of the routine antipneumococcal immunization (2005-2012). | little is known about the incidence and dynamics of occult bacteremia (ob) among infants/young children following the introduction of pneumococcal conjugate vaccines (pcvs) into the national immunization program in israel in 2009-2010. the aim of this study was to characterize the epidemiologic and microbiologic picture of ob among febrile infants/children aged 3-36 months in southern israel, before and after pcvs introduction. | 2016 | 26738763 |
| genotyping and resolution of a case of osteomyelitis in a 16-month-old boy of hispanic/african american ethnicity. | most cases of osteomyelitis in children are caused by staphylococcus aureus, although kingella kingae, various streptococci, and salmonella species also underlie this condition. organisms such as mycobacterium, histoplasma, and cryptococcus are much less commonly identified as etiologic agents in osteomyelitis. this case report describes a 16-month-old boy of hispanic/african american ethnicity who had extensive inflammation of and discharge from his right ankle. imaging studies supported a diag ... | 2016 | 26715611 |
| patterns of kingella kingae disease outbreaks. | kingella kingae outbreaks occur sporadically in childcare centers but remain poorly understood and difficult to identify. | 2016 | 26658382 |