Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| recent advances in otitis media. | otitis media (om) is a pervasive illness in infants and children, and many children suffer multiple episodes during the first years of life. high rates of acute otitis media (aom) are reported in developed and emerging countries. early onset is common in both settings. recurrent om is associated with several factors, including early onset of disease, having a sibling with a history of aom and absence of breast-feeding. early onset disease has been hypothesized to result from eustachian tube dysf ... | 2009 | 19918136 |
| chronic obstructive pulmonary disease: role of bacteria and updated guide to antibacterial selection in the older patient. | chronic obstructive pulmonary disease (copd) remains a major cause of morbidity and mortality worldwide. copd is especially prevalent in the elderly, affecting 25% of those aged>or=75 years. the course of the disease in the elderly is often complicated by co-morbid conditions, and its management is complicated by drug-drug interactions. exacerbations of copd increase rates of hospitalization and mortality and decrease quality of life. exacerbations are marked by an increase from baseline in dysp ... | 2009 | 19929027 |
| laboratory scale bioremediation of diesel hydrocarbon in soil by indigenous bacterial consortium. | in vitro experiment was performed by taking petrol pump soils and diesel in flasks with the micronutrients and macronutrients supplements. cemented bioreactors having sterilized soil and diesel was used for in vivo analysis of diesel hydrocarbon degradation. there were two sets of experiments, first having three bioreactors (1) inoculated by ki. pneumoniae subsp. aerogenes with soil and diesel; (2) with addition of nh4no3; and (3) served as control. in second set, one bioreactor was inoculated b ... | 2009 | 19957891 |
| nosocomial transmission clusters and risk factors in moraxella catarrhalis. | we report an objective examination of nosocomial transmission events derived from long-term (10-year) data from a single medical centre. cluster analysis, based on the temporal proximity of genetically identical isolates of the respiratory pathogen moraxella catarrhalis, identified 40 transmission events involving 33 of the 52 genotypes represented by multiple isolates. there was no evidence of highly transmissible or outbreak-prone genotypes. although most clusters were small (mean size 3.6 iso ... | 2009 | 18789178 |
| bacteriology in acute exacerbation of chronic obstructive pulmonary disease in patients admitted to hospital. | we investigated the bacterial flora and antimicrobial sensitivity in sputum from patients admitted to hospital with acute exacerbation of chronic obstructive pulmonary disease (aecopd) in order to recommend the best empirical treatment for these patients. the survey was a retrospective study of all patients admitted to hvidovre hospital with the diagnosis aecopd during 2004. a total of 118 patients were included. microscopy, culture and sensitivity testing investigated their sputums. clinical an ... | 2009 | 18855228 |
| susceptibility patterns of bacterial isolates from hospitalised patients with respiratory tract infections (moxiaktiv study). | the objective of this study was to determine: (i) the prevalence of resistance in current clinical isolates of streptococcus pneumoniae, staphylococcus aureus, haemophilus influenzae, moraxella catarrhalis and klebsiella pneumoniae; (ii) the prevalence of production of extended-spectrum beta-lactamases (esbls) and methicillin resistance in s. aureus; and (iii) regional differences in the prevalence of esbl production and clonality of k. pneumoniae isolates. pathogens causing respiratory tract in ... | 2009 | 18835763 |
| multilocus sequence typing and pulsed field gel electrophoresis of otitis media causing pathogens. | streptococcus pneumoniae, haemophilus influenzae, and moraxella catarrhalis are the three leading bacteria species associated with otitis media. defining the molecular epidemiology of bacteria known to cause otitis media is of great importance, in both clinical and research settings. pfge and mlst provide data for the characterization of isolates' genetic relatedness, yet they differ in the types of studies for which they are most useful. consequently, knowledge of both techniques is important f ... | 2009 | 18839348 |
| safety and efficacy of intravenous tigecycline in treatment of community-acquired pneumonia: results from a double-blind randomized phase 3 comparison study with levofloxacin. | tigecycline exhibits potent in vitro activity against many community-acquired pneumonia (cap) pathogens, including antibiotic-resistant ones. its spectrum of activity and ability to penetrate lung tissue suggest it may be effective for hospitalized cap patients. hospitalized cap patients (n=418) were randomized to receive intravenous (i.v.) tigecycline or levofloxacin. patients could be switched to oral levofloxacin after receiving 6 or more doses of i.v. study medication. therapy duration was 7 ... | 2009 | 18990531 |
| a class of selective antibacterials derived from a protein kinase inhibitor pharmacophore. | as the need for novel antibiotic classes to combat bacterial drug resistance increases, the paucity of leads resulting from target-based antibacterial screening of pharmaceutical compound libraries is of major concern. one explanation for this lack of success is that antibacterial screening efforts have not leveraged the eukaryotic bias resulting from more extensive chemistry efforts targeting eukaryotic gene families such as g protein-coupled receptors and protein kinases. consistent with a foc ... | 2009 | 19164768 |
| nasopharyngeal carriage and antibiotic resistance of haemophilus influenzae, streptococcus pneumoniae and moraxella catarrhalis in healthy school children in turkey. | 2009 | 19172078 | |
| susceptibilities of haemophilus influenzae, streptococcus pneumoniae, including serotype 19a, and moraxella catarrhalis paediatric isolates from 2005 to 2007 to commonly used antibiotics. | the aim of this study was to evaluate susceptibility to common paediatric antibiotics for streptococcus pneumoniae, non-typeable haemophilus influenzae and moraxella catarrhalis isolated from 2005 through 2007. | 2009 | 19174454 |
| surveillance of pneumococcal-associated disease among hospitalized children in khanh hoa province, vietnam. | to understand the epidemiology of childhood bacterial diseases, including invasive pneumococcal disease, prospective surveillance was conducted among hospitalized children in nha trang, vietnam. | 2009 | 19191620 |
| activity of the new cephalosporin ceftaroline against bacteraemia isolates from patients with community-acquired pneumonia. | the activity of ceftaroline, a novel cephalosporin, was evaluated against 1337 isolates from patients with bacteraemic community-acquired pneumonia (cap) requiring hospitalisation (including 119 haemophilus influenzae, 9 moraxella catarrhalis, 164 staphylococcus aureus, 1007 streptococcus pneumoniae and 38 streptococcus pyogenes). minimum inhibitory concentrations (mics) were determined by broth microdilution according to clinical and laboratory standards institute (clsi) guidelines, and suscept ... | 2009 | 19203863 |
| role of mycoplasma pneumoniae infection in acute exacerbations of chronic obstructive pulmonary disease. | eighty per cent of the cases of acute exacerbation of chronic obstructive pulmonary disease (aecopd) have an infective aetiology, atypical bacteria including mycoplasma pneumoniae accounting for 5-10 % of these. however, the importance of association of m. pneumoniae with episodes of aecopd still remains doubtful. the present study was therefore undertaken to delineate the extent of involvement of m. pneumoniae in patients with aecopd at a referral hospital in delhi, india. sputum samples and th ... | 2009 | 19208881 |
| moraxella catarrhalis pneumonia in an aids patient: a case report. | moraxella catarrhalis pneumonia, although in the immunocompromised patients is very uncommon for community-acquired pneumonia (cap). it demonstrates a potential pathogen with high mortality when the presence of heavy numbers of organisms, intracellularly and extracellularly, in the sputum gram's stained smears confirmed by cultures. in 2007, the authors reported a case of a 28-year-old thai single male patient with acquired-immunodeficiency syndrome (aids) and moraxella catarrhalis pneumonia who ... | 2009 | 19253807 |
| polyarticular septic arthritis due to moraxella canis revealing multiple myeloma. | 2009 | 19286409 | |
| novel ureas and thioureas of 15-membered azalides with antibacterial activity against key respiratory pathogens. | the new ureas and thioureas of 15-membered azalides, n''-substituted 9a-(n'-carbamoyl-gamma-aminopropyl) (4), 9a-(n'-thiocarbamoyl-gamma-aminopropyl) (6), 9a-[n'-(beta-cyanoethyl)-n'-(carbamoyl-gamma-aminopropyl)] (8) and 9a-[n'-(beta-cyanoethyl)-n'-(thiocarbamoyl-gamma-aminopropyl)] (10) of 9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin a (2), were synthesized and structurally characterized by nmr and ir spectroscopic methods and mass spectrometry. the new compounds were evaluated in vitro agains ... | 2009 | 19303171 |
| the incidence of streptococcus pneumoniae otitis media is affected by the polymicrobial environment particularly moraxella catarrhalis in a mouse nasal colonisation model. | otitis media (om) is a highly prevalent paediatric disease with both bacterial and viral triggers of infection. this study has investigated how combinations of bacteria associated with nasal colonisation and the occurrence and absence of viral infection (sendai virus) induce om in a mouse nasal colonisation model. the respiratory virus significantly contributed to bacterial om for all bacterial combinations (p<0.001). streptococcus pneumoniae consistently dominated as the causative bacterium of ... | 2009 | 19306940 |
| epidemiologic and microbiologic characteristics of culture-positive spontaneous otorrhea in children with acute otitis media. | we aimed to describe the epidemiologic and microbiologic characteristics of acute otitis media (aom) with spontaneous otorrhea in children and compare it with aom with intact tympanic membrane in children who underwent tympanocentesis. | 2009 | 19319018 |
| update of cefditoren activity tested against community-acquired pathogens associated with infections of the respiratory tract and skin and skin structures, including recent pharmacodynamic considerations. | antimicrobial resistance rates have noticeably increased among commonly isolated species associated with respiratory tract infections and skin and skin structure infections, particularly streptococcus pneumoniae and staphylococcus aureus. cefditoren, an oral 3rd-generation-like cephalosporin, has been shown to be very active against many gram-positive and gram-negative species with favorable attributes including bactericidal activity and stability against many beta-lactamase enzymes. clinical tr ... | 2009 | 19321284 |
| identification of domains of the hag/mid surface protein recognized by systemic and mucosal antibodies in adults with chronic obstructive pulmonary disease following clearance of moraxella catarrhalis. | moraxella catarrhalis is a common cause of respiratory tract infection in the setting of chronic obstructive pulmonary disease (copd). adults with copd acquire and clear strains of m. catarrhalis from the respiratory tract continuously and develop strain-specific protection following clearance of a strain. in previous work, we identified hag/mid (moraxella immunoglobulin d-binding protein), a large multifunctional surface protein that acts as an adhesin and hemagglutinin, as a target of antibody ... | 2009 | 19321697 |
| moraxella pluranimalium sp. nov., isolated from animal specimens. | four unusual gram-negative, catalase-positive, oxidase-positive, coccus-shaped bacteria isolated from one sheep and three pigs were characterized using phenotypic and molecular genetic methods. on the basis of cellular morphology and biochemical criteria, the isolates were tentatively assigned to the genus moraxella, although the organisms did not appear to correspond to any recognized species. comparative 16s rrna gene sequencing studies demonstrated that the isolates represent a novel subline ... | 2009 | 19329585 |
| m1.mboii and m2.mboii type iis methyltransferases: different specificities, the same target. | methylation of a base in a specific dna sequence protects the dna from nucleolytic cleavage by restriction enzymes recognizing the same sequence. the mboii restriction-modification (r-m) system of moraxella bovis atcc 10900 consists of a restriction endonuclease gene and two methyltransferase genes. the enzymes encoded by this system recognize an asymmetrical sequence 5'-gaaga-3'/3'-cttct-5'. m1.mboii modifies the last adenine in the recognition sequence 5'-gaaga-3' to n(6)-methyladenine. a seco ... | 2009 | 19332813 |
| superantigen- and tlr-dependent activation of tonsillar b cells after receptor-mediated endocytosis. | classical b lymphocyte activation is dependent on bcr cross-linking in combination with physical interaction with th cells. other b cell molecules that contribute to the activation are complement, cytokine, and tlrs recognizing specific pathogen-associated molecular patterns. moraxella (branhamella) catarrhalis is a common gram-negative respiratory pathogen that induces proliferation in human igd-expressing b cells independently of t cell help. the activation is initiated by the b cell superanti ... | 2009 | 19342647 |
| changes in antibiotic resistance of respiratory pathogens in the slovak republic. | respiratory tract infections are one of the most common reasons for public sickness rate. even though they are usually virus-caused, antibiotic prescription is mostly used in primary care. the increase of resistance of bacterial strains observed in the last decade has much to do with this. this increase is connected mainly with the increasing antibiotics consumption and their selective pressure. that is why in many countries, there is an effort to stop this increase by reducing the useless presc ... | 2009 | 19343357 |
| comparison of in vitro activities of tigecycline with other antimicrobial agents against streptococcus pneumoniae, haemophilus influenzae and moraxella catarrhalis in two university hospitals in istanbul, turkey. | we compared the in vitro activities of tigecycline with those of other agents against 97 streptococcus pneumoniae, 140 haemophilus influenzae and 54 moraxella catarrhalis strains isolated in two large university hospitals in istanbul. | 2009 | 19390189 |
| mechanism and implication of cephalosporin penetration into oropharyngeal mucosa. | the aim of this study was to explore the mechanism(s) by which oral cephalosporins penetrate into human oropharyngeal mucosa, and thus, the availability of sufficient concentrations at the site of infection. two oral cephalosporin prototypes, cephalexin (first generation) and cefixime (third generation), were administered to five healthy subjects at two different visits with a 1-week washout period. plasma and saliva samples were collected and drug concentrations were measured using an appropria ... | 2009 | 19396515 |
| virulence mechanisms of moraxella in the pathogenesis of infection. | moraxella catarrhalis is an emerging human-specific pathogen responsible for upper and lower respiratory tract infections. understanding the events in the complex pathogenesis and underlying mechanisms during m. catarrhalis infection is a key to the development of novel therapeutics and vaccines. | 2009 | 19405217 |
| streptococcus pneumoniae and haemophilus influenzae at the initial stage of influenza. | streptococcus pneumoniae and haemophilus influenzae infections in children with influenza have been noted because of the severity of co-infection. in japan, vaccination against s. pneumoniae and h. influenzae infections has been listed in the vaccine program in 2008, but the characteristics of the two organisms, colonizing at the initial stage of influenza infection, have not been investigated in detail. | 2009 | 19419515 |
| molecular epidemiological study of moraxella catarrhalis isolated from nosocomial respiratory infection patients in a community hospital in japan. | moraxella catarrhalis, occasionally, plays the essential role in nosocomial respiratory infection (nri). few studies have reported the route by which this organism spreads in a nosocomial infection outbreak. we identified characteristics of the strains isolated from nri and attempted to reveal the potential nosocomial transmission routes. | 2009 | 19443974 |
| culturable heterotrophic bacteria in seawater and mytilus galloprovincialis from a mediterranean area (northern ionian sea-italy). | although mar piccolo of taranto (ionian sea, italy) is one of the most important mytilus galloprovincialis farming areas, data concerning the natural bacterial microbiota of these mussels and their surrounding environment are still scant. this study was carried out seasonally, throughout a year, to determine culturable heterotrophic bacteria both in the water and mussels samples collected at three sampling sites in the northern ionian sea: s. vito, lido gandoli and lido silvana. culturable heter ... | 2009 | 18301997 |
| index of suspicion. | 2008 | 18310468 | |
| acute bacterial rhinosinusitis and otitis media: changes in pathogenicity following widespread use of pneumococcal conjugate vaccine. | acute bacterial rhinosinusitis and acute otitis media are two of the most common respiratory tract infections. the common pathogenic bacteria associated with these infections are streptococcus pneumoniae, haemophilus influenzae, moraxella catarrhalis, and staphylococcus aureus. with the recent widespread use of pneumococcal conjugate vaccine, there is evidence that there is a shift of both the pneumococcal serotypes and the distribution of pathogenic bacteria. the purpose of this article was to ... | 2008 | 18312870 |
| use of pharmacodynamic endpoints for the evaluation of levofloxacin for the treatment of acute maxillary sinusitis. | sinusitis remains 1 of the most common reasons for antimicrobial prescriptions in the united states, with health care costs approaching $4 billion annually. we utilized the serial sinus aspirate sampling (ssas) technique to obtain daily specimens to evaluate the time course of drug effect in patients with acute maxillary sinusitis. eighteen patients with a radiologically confirmed acute maxillary sinusitis were enrolled into a study evaluating the relationship between levofloxacin exposure and t ... | 2008 | 18313879 |
| in vitro activities of the rx-01 oxazolidinones against hospital and community pathogens. | rx-01_423 and rx-01_667 are two members of the family of oxazolidinones that were designed using a combination of computational and medicinal chemistry and conventional biological techniques. the compounds have a two- to eightfold-improved potency over linezolid against serious gram-positive pathogens, including methicillin-resistant staphylococcus aureus (mrsa), multidrug-resistant streptococci, and vancomycin-resistant enterococci. this enhanced potency extends to the coverage of linezolid-res ... | 2008 | 18316525 |
| antimicrobial susceptibility of haemophilus influenzae and moraxella catarrhalis isolates in eight central, east and baltic european countries in 2005-06: results of the cefditoren surveillance study. | 2008 | 18316820 | |
| use of cethromycin, a new ketolide, for treatment of community-acquired respiratory infections. | the ketolides are a subclass of macrolides, which were designed specifically to overcome macrolide-resistant respiratory pathogens. ketolides lack the cladinose sugar, which is replaced with a 3-ketone group. ketolides bind to a secondary region on domain ii of the 23s rrna subunit. telithromycin was the first ketolide to be approved by the fda in 2004 for treatment of community-acquired pneumonia (cap), acute exacerbations of chronic bronchitis (aecb) and sinusitis. however, in 2006, after repo ... | 2008 | 18321237 |
| impact of infections and normal flora in nonhuman primates on drug development. | preclinical safety studies that are required for the marketing approval of a pharmaceutical include single and repeat dose studies in rodent and nonrodent species. the use of nonhuman primates (nhps), primarily macaques, as the nonrodent species has increased in recent years, in part due to the increase in development of biopharmaceuticals and immunomodulatory agents. depending on the source of the macaques, they may vary in genetic background, normal flora, and/or the incidence of preexisting p ... | 2008 | 18323580 |
| a unique glycosyltransferase involved in the initial assembly of moraxella catarrhalis lipooligosaccharides. | moraxella catarrhalis express three predominant forms of lipooligosaccharide (los) molecules on the bacterial surface. these major glycolipids contain specific carbohydrate epitopes that distinguish each glycoform into serotype a, b, or c los. all three serotypes, however, share a common glucose containing inner-core structure, consisting of an alpha-glucose attached to 2-keto-3-deoxyoctulosonic acid (kdo), which is unique among gram-negative bacteria. many of the los glycosyltransferase genes ( ... | 2008 | 18337458 |
| antimicrobial activity of cefditoren tested against contemporary (2004-2006) isolates of haemophilus influenzae and moraxella catarrhalis responsible for community-acquired respiratory tract infections in the united states. | among orally administered cephalosporins, aminopenicillins (+/- clavulanate), and macrolides, cefditoren was the most potent agent against haemophilus influenzae (mic(50/90), < or =0.008/0.03 microg/ml; 316 isolates including 100 beta-lactamase-positive and 10 beta-lactamase-negative ampicillin-resistant [blnar]) and was 32-, 64-, and 512-fold more potent than cefdinir, cefuroxime, and cefprozil, respectively. cefditoren (mic(50), 0.03 microg/ml) was also > or =32-fold more active against blnar ... | 2008 | 18353594 |
| clinical and laboratory aspects of moraxella catarrhalis bacteremia in children. | moraxella catarrhalis is an uncommon cause of bacteremia in children. we present 17 children with m. catarrhalis bacteremia. most patients were <2 years old (76.4%), immunocompetent (82.3%), and had concomitant lower respiratory symptoms (76.5%). moraxella catarrhalis bacteremia occurs in young immunocompetent children and is frequently associated with lower respiratory tract symptomatology. | 2008 | 18360302 |
| moraxella catarrhalis expresses an unusual hfq protein. | the hfq protein is recognized as a global regulatory molecule that facilitates certain rna-rna interactions in bacteria. blast analysis identified a 630-nucleotide open reading frame in the genome of moraxella catarrhalis atcc 43617 that was highly conserved among m. catarrhalis strains and which encoded a predicted protein with significant homology to the hfq protein of escherichia coli. this protein, containing 210 amino acids, was more than twice as large as the hfq proteins previously descri ... | 2008 | 18362134 |
| moraxella catarrhalis lipooligosaccharide selectively upregulates icam-1 expression on human monocytes and stimulates adjacent naïve monocytes to produce tnf-alpha through cellular cross-talk. | to elucidate the role of moraxella catarrhalis lipooligosaccharide (los) in otitis media with effusion (ome), the effects of los on adhesion antigens of human monocytes were investigated. m. catarrhalis los selectively enhanced intercellular adhesion molecule 1 (icam-1 or cd54) expression on human monocytes by significantly increasing both the surface expression intensity and the percentage of icam-1(+) cells. icam-1 upregulation on human monocytes by the los required surface cd14, tlr4, nf-kapp ... | 2008 | 18363879 |
| serologic cross-reactivity of australian moraxella bovis to vaccinal bacterin strains as determined by competitive elisa. | to conduct a serologic survey and define pili antigenic variability via the serologic cross-reactivity of moraxella bovis isolates from naturally occurring infectious bovine keratoconjunctivitis (ibk) outbreaks in australia. this project applies to the development of an m bovis pili-based vaccine targeting australian strains originating from intensive cattle producing regions. | 2008 | 18363984 |
| mouse models for the study of mucosal vaccination against otitis media. | otitis media (om) is one of the most common infectious diseases in humans. the pathogenesis of om involves nasopharyngeal (np) colonization and retrograde ascension of the pathogen up the eustachian tube into the middle ear (me). due to increasing rates of antibiotic resistance, there is an urgent need for vaccines to prevent infections caused by the most common causes of bacterial om, including nontypeable haemophilus influenzae, streptococcus pneumoniae and moraxella catarrhalis. current vacci ... | 2008 | 18295938 |
| moraxella catarrhalis-dependent tonsillar b cell activation does not lead to apoptosis but to vigorous proliferation resulting in nonspecific igm production. | the respiratory pathogen moraxella catarrhalis has a high affinity for human igd and is mitogenic for peripheral blood b lymphocytes. moraxella igd-binding protein, which is a multifunctional outer membrane protein with adhesive properties, is responsible for the interaction. previous experiments with the ig-binding b cell superantigens protein a and protein l from staphylococcus aureus and peptostreptococcus magnus, respectively, have suggested that nonimmune bcr cross-linking induces b cell ap ... | 2008 | 18372337 |
| age-related genotypic and phenotypic differences in moraxella catarrhalis isolates from children and adults presenting with respiratory disease in 2001-2002. | moraxella catarrhalis is generally associated with upper respiratory tract infections in children and lower respiratory tract infections in adults. however, little is known regarding the population biology of isolates infecting these two age groups. to address this, a population-screening strategy was employed to investigate 195 worldwide m. catarrhalis isolates cultured from children (<5 years of age) and adults (>20 years of age) presenting with respiratory disease in the years 2001-2002. para ... | 2008 | 18375810 |
| high incidence of antimicrobial resistant organisms including extended spectrum beta-lactamase producing enterobacteriaceae and methicillin-resistant staphylococcus aureus in nasopharyngeal and blood isolates of hiv-infected children from cape town, south africa. | there is little information on nasopharyngeal (np) flora or bacteremia in hiv-infected children. our aim was to describe the organisms and antimicrobial resistance patterns in children enrolled in a prospective study comparing daily and three times weekly trimethoprim-sulfamethoxazole (tmp-smx) and isoniazid (inh) or placebo prophylaxis. | 2008 | 18380900 |
| oroantral fistula and genian mucosal flap: a review of 25 cases. | the oroantral fistula is a pathological connection between the maxillary sinus and with the oral cavity. the condition mostly follows dental extraction. | 2008 | 18392507 |
| domain annotation of trimeric autotransporter adhesins--dataa. | trimeric autotransporter adhesins (taas), such as yersinia yada, neisseria nada, moraxella uspas, haemophilus hia and bartonella bada, are important pathogenicity factors of proteobacteria. their high sequence diversity and distinct mosaic-like structure lead to difficulties in the annotation of their sequences. these stem from the large number of short repeats, the presence of compositionally unusual coiled-coils, fuzzy domain boundaries and regions of seemingly low sequence complexity. | 2008 | 18397894 |
| dgge and real-time pcr analysis of lactic acid bacteria in bacterial communities of the phyllosphere of lettuce. | food associated indigenous microbial communities exert antagonistic effects on pathogens and may routinely deliver health relevant microorganisms to the gi tract. by using molecular, culture independent methods including pcr-dgge of 16s rdna-coding regions and real-time pcr (rt-pcr) as well as biolog metabolic fingerprinting, microbial communities on lettuce were analyzed in samples from fields, from supermarkets and soil. amplified 16s rrna gene sequences (57.7%) could be assigned to species pr ... | 2008 | 18398868 |
| the moraxella igd-binding protein mid/hag is an oligomeric autotransporter. | the immunoglobulin d (igd)-binding protein mid/hag of the human respiratory pathogen moraxella catarrhalis is an outer membrane protein of approximately 200kda belonging to the autotransporter family. mid also functions as an adhesin and hemagglutinin. in the present paper, the ultrastructure of mid was mapped. using a series of escherichia coli transformants, the last 210 aa of the c-terminal region were shown to translocate protein mid through the outer membrane suggesting that mid has a beta- ... | 2008 | 18400547 |
| connection between trimethoprim-sulfamethoxazole use and resistance in streptococcus pneumoniae, haemophilus influenzae, and moraxella catarrhalis. | the association between trimethoprim-sulfamethoxazole use and resistance among the major respiratory tract pathogens was investigated by comparing regional consumption of the drug to regional resistance in the following year in 21 central hospital districts in finland. a total of 23,530 streptococcus pneumoniae isolates, 28,320 haemophilus influenzae isolates, and 14,138 moraxella catarrhalis isolates were tested for trimethoprim-sulfamethoxazole susceptibility during the study period (1998-2004 ... | 2008 | 18443116 |
| contribution of trimeric autotransporter c-terminal domains of oligomeric coiled-coil adhesin (oca) family members yada, uspa1, eiba, and hia to translocation of the yada passenger domain and virulence of yersinia enterocolitica. | the oca family is a novel class of autotransporter-adhesins with highest structural similarity in their c-terminal transmembrane region, which supposedly builds a beta-barrel pore in the outer membrane (om). the prototype of the oca family is yada, an adhesin of yersinia enterocolitica and yersinia pseudotuberculosis. yada forms a homotrimeric lollipop-like structure on the bacterial surface. the c-terminal regions of three yada monomers form a barrel in the om and translocate the trimeric n-ter ... | 2008 | 18487327 |
| the moraxella adhesin uspa1 binds to its human ceacam1 receptor by a deformable trimeric coiled-coil. | moraxella catarrhalis is a ubiquitous human-specific bacterium commonly associated with upper and lower respiratory tract infections, including otitis media, sinusitis and chronic obstructive pulmonary disease. the bacterium uses an autotransporter protein uspa1 to target an important human cellular receptor carcinoembryonic antigen-related cell adhesion molecule 1 (ceacam1). using x-ray crystallography, we show that the ceacam1 receptor-binding region of uspa1 unusually consists of an extended, ... | 2008 | 18497748 |
| [experience with bronchomunal used in the combined treatment of patients with bronchial asthma and chronic obstructive pulmonary disease]. | the paper presents the results of treatment in 30 patients aged 16-59 years who have bronchial asthma and chronic obstructive pulmonary disease, by using a bacterial vaccine (bronchomunal) containing antigens of opportunistic bacteria: streptococcus pneumoniae, haemophilus influenzae, klebsiella pneumoniae, staphylococcus aureus, streptococcus viridans, streptococcus piogenes, moraxella catarrhalis. immunotherapy with the vaccine had good and excellent effects in 73.33 of cases; the mean duratio ... | 2008 | 18509908 |
| ribosomal rna-based analysis of the bacterial flora from the conjunctivae of cattle with bovine keratoconjunctivitis (bkc). | bovine keratoconjunctivitis (bkc), colloquially referred to as 'pinkeye', is a disease affecting cattle worldwide; it costs cattle producers millions of dollars in economic loss annually. while moraxella spp. are the primary etiologic agent of pinkeye, surveys of flora from the conjunctivae of livestock from around the world have indicated that a variety of bacterial commensals occupy this niche. we used molecular biology-based methods to determine the composition of bacterial flora in the conju ... | 2008 | 18513895 |
| moraxella bovis pathogenicity: an update. | moraxella bovis is the etiologic agent of infectious bovine keratoconjunctivitis, the most important ocular disease affecting cattle worldwide. the severity of the cases varied from eyes that exhibited mild signs to severe clinical cases with profuse lacrimation, conjunctival swelling, corneal opacity, and ulceration. although the mortality is low, there is a high morbidity and important economic loss in terms of significant reduction in production. this paper examines aspects such as the pathog ... | 2008 | 18514312 |
| prevalence of selected infectious organisms and comparison of two anatomic sampling sites in shelter cats with upper respiratory tract disease. | in order to describe the isolation rates of potential pathogens and to compare anatomic sampling site suitability, nasal and pharyngeal swabs were taken from cats with acute clinical upper respiratory disease in a humane society. dna of feline herpesvirus-1 was amplified from 51 of 52 cats sampled, mycoplasma species were cultured or detected by pcr in samples from 34 of 42 cats sampled for both culture and pcr, and bordetella bronchiseptica was isolated from three of 59 cats sampled for aerobic ... | 2008 | 18539065 |
| changes in abundance of lactobacillus spp. and streptococcus suis in the stomach, jejunum and ileum of piglets after weaning. | this present study investigated the changes in bacterial community composition, with an emphasis on lactobacillus spp. and streptococcus suis populations as potentially beneficial and harmful groups, in the stomach, jejunum and ileum of piglets after weaning (21 days postpartum) by 16s rrna gene-based methods. denaturing gradient gel electrophoresis analysis showed that, after weaning, predominant bands related to lactobacillus spp. disappeared and were replaced by potential pathogenic species, ... | 2008 | 18554303 |
| benefit-risk assessment of telithromycin in the treatment of community-acquired pneumonia. | the purpose of this review is to assess the benefits and risks associated with the use of the ketolide antibacterial telithromycin, currently licensed for the treatment of adults with mild to moderate community-acquired pneumonia (cap). telithromycin is active against both the major (streptococcus pneumoniae, haemophilus influenzae and moraxella catarrhalis) and atypical/intracellular (chlamydophila pneumoniae, legionella pneumophila and mycoplasma pneumoniae) cap pathogens. it is associated wit ... | 2008 | 18558790 |
| galactose residues on the lipooligosaccharide of moraxella catarrhalis 26404 form the epitope recognized by the bactericidal antiserum from conjugate vaccination. | lipooligosaccharide (los) from moraxella catarrhalis has the potential to elicit bactericidal antibodies against the pathogen. we generated los-based conjugate vaccines that elicited bactericidal antibodies in animal models. however, epitopes on the los recognized by the functional anti-los antibodies remain unidentified. in this study, a mutant strain, d4, which lost the recognition by a bactericidal anti-los rabbit serum in western blotting was generated from a serotype c strain 26404 by rando ... | 2008 | 18559429 |
| antimicrobial activity of dc-159a, a new fluoroquinolone, against 1,149 recently collected clinical isolates. | the activity of dc-159a, a novel orally administered fluorinated quinolone, was evaluated by reference broth microdilution or agar dilution methods against 1,149 recently collected clinical isolates from five continents. against pathogens associated with community-acquired respiratory tract infections (ca-rtis), the mic(90)s were 0.12 microg/ml for streptococcus pneumoniae, 0.015 to 0.03 microg/ml for haemophilus influenzae, 0.03 microg/ml for moraxella catarrhalis, and 0.12 microg/ml for beta-h ... | 2008 | 18573936 |
| clinical bacteriology and immunology in acute otitis media in children. | acute otitis media (aom) is the most common disease seen in childhood. streptococcus pneumoniae, non-typeable haemophilus influenzae (nthi), and moraxella catarrhalis are the most frequent pathogens of all aom episodes. the high prevalence of drug-resistant pathogens such as penicillin-resistant s. pneumoniae (prsp) and betalactamase producing or nonproducing ampicillin-resistant h. influenzae (blpar or blnar) is causing serious clinical problems worldwide. prsp and blnar have become important r ... | 2008 | 18574652 |
| an amine: hydroxyacetone aminotransferase from moraxella lacunata wz34 for alaninol synthesis. | an amine:hydroxyacetone aminotransferase from an isolated soil bacterium, moraxella lacunata wz34, was employed to synthesize alaninol in the presence of hydroxyacetone and isopropylamine in this study. the optimal carbon and nitrogen sources were glycerol and beef extract, respectively. a wide range of amino donor specificity was detected with the aminotransferase, which exhibited a relative high activity (9.83 u ml(-1)) in the presence of isopropylamine. the enzyme was the most active at ph 8. ... | 2008 | 17849151 |
| in vitro and in vivo antibacterial activities of dc-159a, a new fluoroquinolone. | dc-159a is a new 8-methoxy fluoroquinolone that possesses a broad spectrum of antibacterial activity, with extended activity against gram-positive pathogens, especially streptococci and staphylococci from patients with community-acquired infections. dc-159a showed activity against streptococcus spp. (mic(90), 0.12 microg/ml) and inhibited the growth of 90% of levofloxacin-intermediate and -resistant strains at 1 microg/ml. the mic 90s of dc-159a against staphylococcus spp. were 0.5 microg/ml or ... | 2008 | 17938194 |
| diversity of bacterial isolates from commercial and homemade composts. | the diversity of heterotrophic bacterial isolates of three commercial and two homemade composts was studied. the commercial composts were produced from poultry litter (pc), sewage sludge (sc), municipal solid waste (mc), and homemade composts (thermal compost [dc] and vermicompost [vc]) from food wastes. the taxonomic and physiological diversity of the heterotrophic culturable bacteria was assessed using phenotypic and genotypic characterization and the analysis of the partial 16s rrna gene sequ ... | 2008 | 17876655 |
| interventions for prevention of otitis media may be most effective if implemented in the first weeks of life. | for indigenous australian children living in remote communities, onset of otitis media commences within weeks of birth and is associated with early nasopharyngeal colonisation with multiple respiratory bacterial pathogens: streptococcus pneumoniae, haemophilus influenzae, and moraxella catarrhalis. the high prevalence of eardrum perforation and the failure of standard therapies to cure or prevent om in this population require urgent attention. the objective of this study was to measure the chang ... | 2008 | 18006084 |
| assessment of methodological quality and sources of variation in the magnitude of vaccine efficacy: a systematic review of studies from 1960 to 2005 reporting immunization with moraxella bovis vaccines in young cattle. | a review was conducted of all identified literature evaluating moraxella bovis vaccines efficacy in preventing pinkeye in beef calves. from 292 publications identified by the search, data on 123 unique vaccine-to-control comparisons were extracted from 38 studies published in english from 1960 to 2005. descriptive analysis was performed and an analysis of sources of variation evaluated. use of methods to control bias such as randomization and blinding were associated with decreased vaccine effic ... | 2008 | 18054816 |
| moraxella catarrhalis synthesizes an autotransporter that is an acid phosphatase. | moraxella catarrhalis o35e was shown to synthesize a 105-kda protein that has similarity to both acid phosphatases and autotransporters. the n-terminal portion of the m. catarrhalis acid phosphatase a (mapa) was most similar (the blast probability score was 10(-10)) to bacterial class a nonspecific acid phosphatases. the central region of the mapa protein had similarity to passenger domains of other autotransporter proteins, whereas the c-terminal portion of mapa resembled the translocation doma ... | 2008 | 18065547 |
| outer membrane protein uspa1 and lipooligosaccharide are involved in invasion of human epithelial cells by moraxella catarrhalis. | invasion of non-professional phagocytes is a strategy employed by several mucosal pathogens, but has not been investigated in detail for moraxella catarrhalis, a major cause of human respiratory tract infections. we investigated the role of outer membrane protein (omp) uspa1 and lipooligosaccharide (los) in m. catarrhalis invasion into epithelial cells. an isogenic mutant of strain o35e, which lacked expression of the uspa1 adhesin, demonstrated not only severely impaired adherence (86%) to but ... | 2008 | 18069032 |
| perlucidibaca piscinae gen. nov., sp. nov., a freshwater bacterium belonging to the family moraxellaceae. | a freshwater bacterium, designated imcc1704(t), was isolated from a eutrophic pond. the strain was gram-negative, oxidase-positive, catalase-negative, chemoheterotrophic and facultatively aerobic with cells that were motile rods with a single polar flagellum. based on 16s rrna gene sequence similarity analyses, the novel strain was most closely related to the genera alkanindiges (91.7%), acinetobacter (89.0-91.2%), moraxella (87.9-90.1%), psychrobacter (87.2-89.5%) and enhydrobacter (87.8%). phy ... | 2008 | 18175691 |
| [antimicrobial susceptibility of 80 moraxella catarrhalis strains isolated in the children's hospital of tunis]. | eighty non-repetitive strains of moraxella catarrhalis, isolated in tunis children's hospital during five years from 1998 to 2002, were tested for their antimicrobial susceptibility, 95% of these strains were isolated from lung samples: 57.5% from trachea products, 35% from sputum and 2.5% from bronchial washings. the majority of strains (72%) were obtained from children under two years old. antimicrobial susceptibility study showed that 95% of stains were beta-lactamase-producing, therefore the ... | 2008 | 18178028 |
| differential regulation of moraxella catarrhalis-induced interleukin-8 response by protein kinase c isoforms. | moraxella catarrhalis is a major cause of infectious exacerbations of chronic obstructive lung disease. in pulmonary epithelial cells, m. catarrhalis induces release of the pro-inflammatory cytokine interleukin (il)-8, which plays a pivotal role in orchestrating airway inflammation. the present study demonstrated that protein kinase (pk)c was activated by moraxella infection and positively regulated m. catarrhalis-triggered nuclear factor (nf)-kappab activation and subsequent il-8 release. activ ... | 2008 | 18184679 |
| microbial contamination of dental unit waterlines in istanbul, turkey. | the water used in dental unit waterlines (duwls) acts as a coolant for the high-speed equipment and as an irrigant during dental treatments. there are kind of water tanks. duwls provide a favorable environment for microbial biofilm and multiplation primarily due to the high surface in the tubing and the character of fluid dynamics in narrow, smooth-walled waterlines. biofilms can harbour opportunist pathogens such as legionella sp., pseudomonas sp. several studies have shown that duwls have high ... | 2008 | 18210208 |
| [moraxella catarrhalis endocarditis in an immunocompetent adult]. | 2008 | 18221679 | |
| moraxella osloensis gene expression in the slug host deroceras reticulatum. | the bacterium moraxella osloensis is a mutualistic symbiont of the slug-parasitic nematode phasmarhabditis hermaphrodita. in nature, p. hermaphrodita vectors m. osloensis into the shell cavity of the slug host deroceras reticulatum in which the bacteria multiply and kill the slug. as m. osloensis is the main killing agent, genes expressed by m. osloensis in the slug are likely to play important roles in virulence. studies on pathogenic interactions between bacteria and lower order hosts are few, ... | 2008 | 18226222 |
| mining the moraxella catarrhalis genome: identification of potential vaccine antigens expressed during human infection. | moraxella catarrhalis is an important cause of respiratory infections in adults and otitis media in children. developing an effective vaccine would reduce the morbidity, mortality, and costs associated with such infections. an unfinished genome sequence of a strain of m. catarrhalis available in the genbank database was analyzed, and open reading frames predicted to encode potential vaccine candidates were identified. three genes encoding proteins having molecular masses of approximately 22, 75, ... | 2008 | 18227159 |
| moraxella-dependent alpha 1-antichymotrypsin neutralization: a unique virulence mechanism. | the acute phase reactant and protease inhibitor alpha(1)-antichymotrypsin is considered to play a protective role in the airways, but whether it interacts with respiratory bacteria is not known. we analyzed whether the common respiratory pathogens streptococcus pneumoniae, haemophilus influenzae, moraxella catarrhalis, and other bacterial species interact with antichymotrypsin. m. catarrhalis was the only species that bound antichymotrypsin among 25 bacterial species tested by flow cytometry and ... | 2008 | 18096871 |
| symptom profile of common colds in school-aged children. | signs and symptoms of a common cold reported in young children are those perceived by caretakers. objective signs include cough, fever, and sneezing. subjective symptoms include nasal congestion, feverishness, headache, and sore throat. school-aged children may provide a more accurate picture of the symptom profile during colds because they can self-report. | 2008 | 18162930 |
| seasonal distribution of otitis media pathogens among costa rican children. | otitis media is an important cause of pediatric consultation, and knowledge of yearly pathogen distribution might improve antimicrobial selection. | 2008 | 18162931 |
| bacterial extracts for the prevention of acute exacerbations in chronic obstructive pulmonary disease: a point of view. | given the high prevalence of chronic obstructive pulmonary disease (copd), the impact of exacerbations on quality of life, and the costs incurred, effective ways for the prevention of exacerbations, and for reductions in the severity and duration of copd symptoms are needed. bacterial immunostimulation has been advocated as a management strategy in copd for the purposes of preventing acute exacerbations. in particular, it suggests that the use of oral multicomponent vaccines may reduce the sever ... | 2008 | 18164190 |
| a multiplex pcr-based reverse line blot hybridization (mpcr/rlb) assay for detection of bacterial respiratory pathogens in children with pneumonia. | to develop and evaluate a novel method for simultaneous identification of 12 potential bacterial pathogens in children with community-acquired pneumonia. | 2008 | 18085683 |
| purification of alpha1-antichymotrypsin from human plasma with recombinant m. catarrhalis ubiquitous surface protein a1. | alpha 1-antichymotrypsin (act) inhibits chymotrypsin-like enzymes, particularly neutrophil cathepsin g. moreover, act in its native form suppresses chemotaxis of neutrophils and decreases neutrophil production of superoxide radicals. we recently showed that moraxella catarrhalis ubiquitous surface protein (usp) a1 is able to specifically bind act in the context of a novel virulence mechanism. in this study, we report that recombinant uspa1(557-704) coupled to cnbr-sepharose can be used in a simp ... | 2008 | 18242635 |
| recovery of potential pathogens in the nasopharynx of healthy and otitis media-prone children and their smoking and nonsmoking parents. | exposure to smoking is associated with colonization with pathogenic bacteria. this study investigated the frequency of isolation of potential pathogens in the nasopharynx of healthy and otitis media-prone (omp) children and their smoking or nonsmoking parents. | 2008 | 18998498 |
| assessment of the bioequivalence of two formulations of clarithromycin extended-release 500-mg tablets under fasting and fed conditions: a single-dose, randomized, open-label, two-period, two-way crossover study in healthy jordanian male volunteers. | clarithromycin extended-release tablets are indicated for the treatment of adults with acute maxillary sinusitis caused by haemophilus influenzae, moraxella catarrhalis, or streptococcus pneumoniae; acute bacterial exacerbation of chronic bronchitis due to h influenzae, haemophilus parainfluenzae, m catarrhalis, or s pneumoniae; or community acquired pneumonia due to h influenzae, h parainfluenzae, m catarrhalis, s pneumoniae, chlamydia pneumoniae, or mycoplasma pneumoniae. | 2008 | 19014838 |
| laboratory maintenance of moraxella catarrhalis. | moraxella catarrhalis is a gram-negative bacterium that has recently emerged as the third leading cause of bacterial ear infections in children. this organism is also responsible for a variety of upper respiratory tract illnesses in adults, including approximately 10% of all cases of respiratory exacerbations in patients with chronic obstructive pulmonary disease (copd). there is interest in studying m. catarrhalis for vaccine development, and this unit provides guidelines for the laboratory mai ... | 2008 | 19016443 |
| [susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibiotics (2005)]. | from october 2005 to september 2006, we collected the specimen from 366 patients with lower respiratory tract infections in 12 institutions in japan, and investigated the susceptibilities of isolated bacteria to various antibacterial agents and patients' characteristics. of 411 strains that were isolated from specimen (mainly from sputum) and assumed to be bacteria causing in infection, 406 strains were examined. the isolated bacteria were: staphylococcus aureus 70, streptococcus pneumoniae 85, ... | 2008 | 19024644 |
| [nationwide susceptibility surveillance of ciprofloxacin and various parenteral antimicrobials against bacteria isolated from patients with severe infections--third ciproxan injection special survey (2005)]. | we conducted 3 nationwide surveillance studies between 2001 and 2005 at 39 participating institutions throughout japan according to the special survey plan to investigate susceptibility to ciprofloxacin (cpfx) and various parenteral antimicrobials using clinical isolates from patients with severe infection during the reexamination period of parenteral cpfx. results of the first special survey (2001) were already reported in this journal. the current third special survey (2005) was conducted at 3 ... | 2008 | 19024645 |
| antibacterial activity of cefditoren against major community-acquired respiratory pathogens recently isolated in italy. | in this study we evaluated the in vitro activities of cefditoren--a broad-spectrum oral cephalosporin--and other comparator agents against 2,396 fresh isolates from community-acquired respiratory tract infections, collected from 6 clinical italian microbiology laboratories. on penicillin-susceptible pneumococci and streptococcus pyogenes, cefditoren demonstrated to be the most active antibiotic (mic(90)values of 0.03 and 0.06 mg/l respectively), showing only a slight decrease in potency on penic ... | 2008 | 19028617 |
| mucosal vaccination against bacterial respiratory infections. | mucosal vaccination offers attractive advantages to conventional systemic vaccination, such as higher levels of antibodies and protection at the airway surface. this review gives an overview of recent experimental and clinical data on nasal, oral and sublingual vaccines against bacterial respiratory pathogens, such as streptococcus pneumoniae , haemophilus influenzae , neisseria meningitidis , moraxella catarrhalis , bordetella pertussis , pseudomonas aeruginosa and mycobacterium tuberculosis . ... | 2008 | 18844598 |
| ceacam1 inhibits toll-like receptor 2-triggered antibacterial responses of human pulmonary epithelial cells. | although moraxella catarrhalis and neisseria meningitidis are important human pathogens, they often colonize the human respiratory tract without causing overt clinical symptoms. both pathogens express structurally unrelated proteins that share the ability to stimulate the adhesion molecule ceacam1 expressed on human cells. here we demonstrate that the interaction of ceacam1 with ubiquitous surface protein a1 expressed on m. catarrhalis or with opacity-associated proteins on n. meningitidis resul ... | 2008 | 18836450 |
| moraxella catarrhalis m35 is a general porin that is important for growth under nutrient-limiting conditions and in the nasopharynges of mice. | moraxella catarrhalis is a gram-negative respiratory pathogen that is an important causative agent for otitis media and exacerbations of chronic obstructive pulmonary disease. we have previously predicted the outer membrane protein m35 to be a general porin, and in the current study, we have investigated the function of m35 and its importance for survival of m. catarrhalis in vivo. lipid bilayer experiments reveal that refolded m35 functions as a channel that is typical of gram-negative bacteria ... | 2008 | 18931134 |
| tracking resistance among bacterial respiratory tract pathogens: summary of findings of the trust surveillance initiative, 2001-2005. | antimicrobial resistance observed among common respiratory tract pathogens--streptococcus pneumoniae, haemophilus influenzae, and moraxella catarrhalis--may complicate empiric therapeutic selection to treat community-acquired respiratory tract infections. the tracking resistance in the united states today (trust) study determined the in vitro activities of frequently prescribed antimicrobial agents against isolates collected from all 50 states from 2001 to 2005. for s pneumoniae (n = 27,781), su ... | 2008 | 18931466 |
| antimicrobial susceptibility profiles among common respiratory tract pathogens: a global perspective. | antimicrobial resistance by common respiratory tract pathogens remains a global concern, but surveillance programs allow us to recognize trends in susceptibility that may help guide empiric antimicrobial selection. during 2003 to 2004, the global landscape on the bactericidal activity of levofloxacin (global) surveillance program collected 9323 isolates of streptococcus pneumoniae, 5828 isolates of haemophilus influenzae, and 1878 isolates of moraxella catarrhalis from 15 countries worldwide, an ... | 2008 | 18931467 |
| design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics. | we have developed a first generation of hybrid sparsomycin-linezolid compounds into a new family of orally bioavailable biaryloxazolidinones that have activity against both linezolid-susceptible and -resistant gram-positive bacteria as well as the fastidious gram-negative bacteria haemophilus influenzae and moraxella catarrahalis. the convergent synthesis of these new compounds is detailed. | 2008 | 18947996 |
| design at the atomic level: generation of novel hybrid biaryloxazolidinones as promising new antibiotics. | from the x-ray crystal structures of linezolid and the non-selective antibiotic sparsomycin, we have derived a new family of hybrid oxazolidinones. from this initial compound set we have developed a new biaryloxazolidinone scaffold that shows both potent antimicrobial activity as well as selective inhibition of ribosomal translation. the synthesis of these compounds is outlined. | 2008 | 18951792 |
| preliminary studies on the etiology of keratoconjunctivitis in reindeer (rangifer tarandus tarandus) calves in alaska. | keratoconjunctivitis outbreaks occur each summer in reindeer (rangifer tarandus tarandus) herds in western alaska, usa. this condition has not been well characterized nor has a definitive primary etiologic agent been identified. we evaluated the eyes of 660 calves near nome, alaska, between 29 june and 14 july 2005. clinical signs of keratoconjunctivitis were observed in 26/660 calves (3.9%). samples were collected from the conjunctival sac of both affected (n=22) and unaffected (n=24) animals f ... | 2008 | 18957667 |
| "moraxella lacunata" endocarditis treated with penicillin. | the case report of a young male with endocarditis caused by moraxella lacunata is presented. although a well recognized cause of keratitis, conjunctivitis, and sinusitis; very few cases of endocarditis by this rare pathogen are reported in literature. patient showed a prompt response when empirical therapy was de-escalated to penicillin, after receiving culture and sensitivity report from microbiology department. | 2008 | 18988396 |
| assessment of different formulations of oral mycobacterium bovis bacille calmette-guérin (bcg) vaccine in rodent models for immunogenicity and protection against aerosol challenge with m. bovis. | bovine tuberculosis (btb) caused by infection with mycobacterium bovis is causing considerable economic loss to farmers and government in the united kingdom as its incidence is increasing. efforts to control btb in the uk are hampered by the infection in eurasian badgers (meles meles) that represent a wildlife reservoir and source of recurrent m. bovis exposure to cattle. vaccination of badgers with the human tb vaccine, m. bovis bacille calmette-guérin (bcg), in oral bait represents a possible ... | 2008 | 18789366 |