Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| immunization with a 22-kda outer membrane protein elicits protective immunity to multidrug-resistant acinetobacter baumannii. | a. baumannii infections are becoming more and more serious health issues with rapid emerging of multidrug and extremely drug resistant strains, and therefore, there is an urgent need for the development of nonantibiotic-based intervention strategies. this study aimed at identifying whether an outer membrane protein with molecular weight of about 22 kda (omp22) holds the potentials to be an efficient vaccine candidate and combat a. baumannii infection. omp22 which has a molecule length of 217 ami ... | 2016 | 26853590 |
| the influence of biofilm formation and multidrug resistance on environmental survival of clinical and environmental isolates of acinetobacter baumannii. | acinetobacter baumannii is a gram-negative, opportunistic pathogen. its ability to form biofilm and increasing resistance to antibiotic agents present challenges for infection control. a better understanding of the influence of biofilm formation and antibiotic resistance on environmental persistence of a baumannii in hospital settings is needed for more effective infection control. | 2016 | 26851196 |
| single amino acid substitution gly186val in ades restores tigecycline susceptibility of acinetobacter baumannii. | amino acid substitutions within the aders two-component system are believed to result in overexpression of the adeabc efflux pump and extensive resistance to antibiotics in clinical acinetobacter baumannii isolates. however, the exact amino acid substitutions in aders that cause overexpression of the adeabc efflux pump remain unclear. we elucidated the role of amino acid substitutions in aders by a complementation assay in an aders knockout strain of a. baumannii. | 2016 | 26850720 |
| enhanced efficacy of combinations of pexiganan with colistin versus acinetobacter baumannii in experimental sepsis. | we investigated the efficacy of colistin combined with pexiganan in experimental mouse models of acinetobacter baumannii infection.adult male balb/c mice received intraperitoneally 1 ml saline containing 2 × 10 cfu of susceptible and multiresistant a. baumannii. two hours after bacterial challenge, animals received 1 mg/kg of colistin, 1 mg/kg of pexiganan, or 1 mg/kg of colistin plus 1 mg/kg of pexiganan.blood culture positivity, the quantities of bacteria in the intra-abdominal fluid, the rate ... | 2016 | 26849630 |
| multidrug resistance related to biofilm formation in acinetobacter baumannii and klebsiella pneumoniae clinical strains from different pulsotypes. | the emergence of acinetobacter baumannii and klebsiella pneumoniae strains in the hospital environment has been associated with the presence of multiple genetic elements, virulence factors and the ability to form biofilms. this study evaluated the biofilm formation ability of clinical and environmental a. baumannii and k. pneumoniae strains, isolated from various sources and presenting different molecular characteristics, resistance profiles and pulsed-field gel electrophoresis patterns. fifty-t ... | 2016 | 26846651 |
| national epidemiology of carbapenem-resistant and extensively drug-resistant gram-negative bacteria isolated from blood samples in china in 2013. | although antimicrobial resistance poses a great challenge to clinicians in china, there are limited antimicrobial resistance data on gram-negative bacteria nationwide. we investigated the phenotypic characteristics of carbapenem-resistant escherichia coli (crec) and klebsiella pneumoniae (crkp) as well as extensively drug-resistant strains of pseudomonas aeruginosa (xdrpa) and acinetobacter baumannii (xdrab) isolated from blood cultures in china. data were collected on 24113 isolates from the ch ... | 2016 | 26846351 |
| [candida peritonitis and sepsis due to acinetobacter baumannii in peritoneal dialysis: an association with prognosis not always unfavourable]. | fungal infections have a high incidence in patients receiving peritoneal dialysis. (1) peritoneal dialysis is often complicated by peritonitis which has only minimally mycotic etiology, but nonetheless it is associated with 15-45% mortality (8). the opportunistic pathogens such as candida can cause infection in immunocompromised conditions. even the acinetobacter tends to infect immunocompromised individuals and it has the same risk factors for infection as candida: immunosuppression, malignanc ... | 2016 | 26845211 |
| [carbapenem-resistant acinetobacter baumannii causing osteomyelitis and infections of skin and soft tissues in hospitals of medellín, colombia]. | acinetobacter baumannii is an opportunistic bacterium which infects seriously ill patients, particularly those with ventilator-associated pneumonia and bacteremia. the emergence of resistance to carbapenem limits the options for the treatment of infections caused by this bacterium. | 2016 | 26844441 |
| first report of ctx-m-15-producing acinetobacter baumannii in brazil. | 2016 | 26810614 | |
| ader protein regulates adeabc expression by binding to a direct-repeat motif in the intercistronic spacer. | overexpression of the efflux pump adeabc is associated with tigecycline resistance of multi-drug resistant acinetobacter baumannii (mdrab). a two-component regulatory system, sensor ades and regulator ader proteins regulate the pump. however, the detailed mechanism of the ader protein to enhance the expression of adeabc operon is not well defined. we illustrated the biological characteristics of ader proteins by comparing a mutant ader protein of a tigecycline resistant mdrab to the wild ader pr ... | 2016 | 26805619 |
| structural insights into outer membrane permeability of acinetobacter baumannii. | bacterial resistance against antibiotics is an increasing global health problem. in gram-negative bacteria the low permeability of the outer membrane (om) is a major factor contributing to resistance, making it important to understand channel-mediated small-molecule passage of the om. acinetobacter baumannii has five occ (om carboxylate channel) proteins, which collectively are of major importance for the entry of small molecules. to improve our understanding of the om permeability of a. baumann ... | 2016 | 26805524 |
| risk factors and outcomes of hospitalized patients with blood infections caused by multidrug-resistant acinetobacter baumannii complex in a hospital of northern china. | the purpose of this study was to determine the risk factors and outcomes of bloodstream infections caused by multidrug-resistant (mdr) acinetobacter baumannii complex in a hospital of northern china. risk factors associated with mdr a baumannii complex included older age, pneumonia, using drainage catheters, and intensive care unit stay. multivariate analysis showed that multidrug resistance and mechanical ventilation were identified as independent risk factors for 30-day mortality in patients w ... | 2016 | 26804303 |
| isaba1/blaoxa-23: a serious obstacle to controlling the spread and treatment of acinetobacter baumannii strains. | this study demonstrated a direct correlation between acinetobacter baumannii clusters carrying the isaba1/blaoxa-23 gene and increased minimal inhibitory concentrations for carbapenems and greater clonal diversity. our findings showed that clusters carrying isaba1 are widely distributed in our hospital, further complicating the treatment and control of infections caused by a baumannii. | 2016 | 26804302 |
| characterization of cimex lectularius (bedbug) defensin peptide and its antimicrobial activity against human skin microflora. | antimicrobial peptides are components of both vertebrate and invertebrate innate immune systems that are expressed in response to exposure to bacterial antigens. naturally occurring antimicrobial peptides from evolutionarily ancient species have been extensively studied and are being developed as potential therapeutics against antibiotic resistant microorganisms. in this study, a putative cimex lectularius (bedbug, cl) defensin is characterized for its effectiveness against human skin flora incl ... | 2016 | 26802465 |
| outcomes in meningitis/ventriculitis treated with intravenous or intraventricular plus intravenous colistin. | the aim of this work is to evaluate the outcome of patients treated with intrathecal colistin for meningitis/ventriculitis. | 2016 | 26801512 |
| multidrug-resistant organisms detected in refugee patients admitted to a university hospital, germany june‒december 2015. | multidrug-resistant gram-negative bacteria (mdr gnb) were found to colonise 60.8% (95% confidence interval: 52.3-68.9) of 143 refugee patients mainly from syria (47), afghanistan (29), and somalia (14) admitted to the university hospital frankfurt, germany, between june and december 2015. this percentage exceeds the prevalence of mdr gnb in resident patients four-fold. healthcare personnel should be aware of this and the need to implement or adapt adequate infection control measures. | 2016 | 26794850 |
| nosocomial infection and its molecular mechanisms of antibiotic resistance. | nosocomial infection is a kind of infection, which is spread in various hospital environments, and leads to many serious diseases (e.g. pneumonia, urinary tract infection, gastroenteritis, and puerperal fever), and causes higher mortality than community-acquired infection. bacteria are predominant among all the nosocomial infection-associated pathogens, thus a large number of antibiotics, such as aminoglycosides, penicillins, cephalosporins, and carbapenems, are adopted in clinical treatment. ho ... | 2016 | 26877142 |
| management of a hospital outbreak of extensively drug-resistant acinetobacter baumannii using a multimodal intervention including daily chlorhexidine baths. | extensively drug-resistant acinetobacter baumannii (xdr-ab) is an increasingly important cause of healthcare-associated infection. uncertainties remain concerning optimal control measures for healthcare-associated outbreaks. | 2016 | 26876749 |
| trends in the distribution and antimicrobial susceptibility of causative pathogens of device-associated infection in korean intensive care units from 2006 to 2013: results from the korean nosocomial infections surveillance system (konis). | for all countries, information on pathogens causing healthcare-associated infections is important in order to develop proper strategies for preventing and treating nosocomial infections. | 2016 | 26876746 |
| [analysis of clinical manifestations and risk factors of mortality in acinetobacter baumannii bloodstream infection]. | to explore the clinical manifestations, antimicrobial therapy, and risk factors of mortality in patients with acinetobacter baumannii bloodstream infection. | 2016 | 26875581 |
| controlling endemic multidrug-resistant acinetobacter baumannii in intensive care units using antimicrobial stewardship and infection control. | nosocomial infections caused by multidrug-resistant (mdr) acinetobacter baumannii have become public-health problem. however, few studies have evaluated the control of endemic mdr a. baumannii in intensive care units (icus). therefore, we investigated the effectiveness of antimicrobial stewardship and comprehensive intensified infection control measures for controlling endemic mdr a. baumannii in icus at a tertiary care center. | 2016 | 26874513 |
| the long-term survival of acinetobacter baumannii atcc 19606(t) under nutrient-deprived conditions does not require the entry into the viable but non-culturable state. | acinetobacter baumannii possesses a tremendous potential to thrive under hostile conditions. to learn more about its survival strategy and capacity to persist in the environment, we studied the effect of temperature, nutrient deprivation and dryness on the long-term survival of two a. baumannii strains (atcc 19606(t) and a clinical isolate). our results revealed that both strains show a great persistence under stress that appears to involve a bust-and-boom strategy. bacterial survival was differ ... | 2016 | 26872882 |
| sugar-grafted cyclodextrin nanocarrier as a "trojan horse" for potentiating antibiotic activity. | the use of "trojan horse" nanocarriers for antibiotics to enhance the activity of antibiotics against susceptible and resistant bacteria is investigated. | 2016 | 26792570 |
| first description of two sequence type 2 acinetobacter baumannii isolates carrying oxa-23 carbapenemase in pagellus acarne fished from the mediterranean sea near bejaia, algeria. | to determine the occurrence of carbapenem-resistantacinetobacter baumanniiin fish fished from the mediterranean sea near the bejaia coast (algeria), we studied 300 gills and gut samples that had been randomly and prospectively collected during 1 year. after screening on selective agar media, using pcr arrays and whole-genome sequencing, we identified for the first time two oxa-23-producinga. baumanniistrains belonging to the widespread sequence type 2 (st2)/international clone ii and harboring a ... | 2016 | 26787693 |
| antibacterial peptide cecropinb2 production via various host and construct systems. | cecropin is a cationic antibacterial peptide composed of 35-39 residues. this peptide has been identified as possessing strong antibacterial activity and low toxicity against eukaryotic cells, and it has been claimed that some types of the cecropin family of peptides are capable of killing cancer cells. in this study, the host effect of cloning antibacterial peptide cecropinb2 was investigated. three different host expression systems were chosen, i.e., escherichia coli, bacillus subtilis and pic ... | 2016 | 26784164 |
| carbapenem-resistant acinetobacter baumannii st78 with oxa-72 carbapenemase and esbl gene blactx-m-115. | 2016 | 26782774 | |
| a two-centre evaluation of rapidec® carba np for carbapenemase detection in enterobacteriaceae, pseudomonas aeruginosa and acinetobacter spp. | we evaluated the rapidec(®) carba np assay (biomérieux sa, marcy-l'étoile, france), a colorimetric test for rapid detection of carbapenemases, at two sites: karolinska university laboratory and phe's national reference laboratory. | 2016 | 26769895 |
| bloodstream infections in hospitalized children: epidemiology and antimicrobial susceptibilities. | bloodstream infection is a major cause of morbidity and mortality. much of our understanding of the epidemiology and resistance patterns of bloodstream infections comes from studies of hospitalized adults. | 2016 | 26766146 |
| the efficiency of routine endotracheal aspirate cultures compared to bronchoalveolar lavage cultures in ventilator-associated pneumonia diagnosis. | ventilator-associated pneumonia (vap) is the most common nosocomial infection in intensive care units (icus) and its mortality rate varies from 24% to 50%. the most important factor in decreasing the mortality is administering adequate antibiotics as early as possible. in this study, we investigate the efficiency of routine endotracheal aspirate (ea) cultures to identify the etiology of vap earlier. | 2016 | 26755218 |
| antibacterial properties of tebipenem pivoxil tablet, a new oral carbapenem preparation against a variety of pathogenic bacteria in vitro and in vivo. | to systemically investigate the in vitro and in vivo antibacterial properties of tebipenem pivoxil tablet. in addition, acute toxicity of this preparation was also studied. | 2016 | 26751436 |
| national survey of infectious diseases physicians on prevention practices for multidrug-resistant acinetobacter baumannii in thailand. | 2016 | 26751004 | |
| multi-substrate biodegradation interaction of 1, 4-dioxane and btex mixtures by acinetobacter baumannii dd1. | this study evaluated substrate interactions during the aerobic biodegradation of 1, 4-dioxane and btex mixtures by a pure culture, acinetobacter baumannii dd1, which is capable of utilizing 1, 4-dioxane for growth. a. baumannii dd1 could utilize btex as a sole carbon source, but could not utilize m-xylene and p-xylene. in binary mixtures, there was a lag of about 14 h before the degradation of bte, and 1, 4-dioxane only started to be utilized when bte was completely degraded by 1, 4-dioxane-grow ... | 2016 | 26749222 |
| characterization of carbapenem-resistant acinetobacter calcoaceticus-baumannii complex isolates from nosocomial bloodstream infections in southern iran. | acinetobacter baumannii is an important opportunistic bacterial pathogen responsible for serious infections in hospitalized patients. from a total of 78 consecutive non-repetitive acinetobacter spp. isolates from patients with blood infections, 61 were carbapenem resistant, which were positive for blaoxa-51-like (96.7%), blaoxa-23-like (77 %), blaoxa-58-like (8.1%) and blaoxa-40-like genes (32.8%) by multiplex pcr. the isolates were identified as a. baumannii (n = 59) and acinetobacter nosocomia ... | 2016 | 26747061 |
| holarrhena antidysenterica extract and its steroidal alkaloid, conessine, as resistance-modifying agents against extensively drug-resistant acinetobacter baumannii. | emergence and spread of antibiotic-resistant acinetobacter baumannii have become a major public health concern. this study was designed to investigate the efficacy of holarrhena antidysenterica extract and its major steroidal alkaloid conessine as resistance-modifying agents (rmas) on the susceptibility of a. baumannii to novobiocin and rifampicin. a significant synergistic activity of both the extract and conessine in combination with either novobiocin or rifampicin with fractional inhibitory c ... | 2016 | 26745443 |
| molecular epidemiology and drug resistance of acinetobacter baumannii isolated from hospitals in southern poland: icu as a risk factor for xdr strains. | the objectives of the present study were to investigate the carbapenemase and metallo-beta-lactamase genes of acinetobacter baumannii clinical isolates by polymerase chain reaction (pcr) and real time pcr and to determine the molecular epidemiology of the strains using the diversilab tool. from these data, correlations between drug resistance, resistance genes, and epidemiological clones may be revealed. the study was conducted on 125 a. baumannii collected over the 2013 year. the majority of th ... | 2016 | 26745326 |
| evaluation of antimicrobial and antiviral activities of different venoms. | animals' venomous secretions or peptides obtained from those secretions are used in the development of new therapeutic agents. the aims of this study were to investigate antimicrobial and antiviral activity of four different venoms obtained from the frog named bufo arenarum and the snakes crotalus atrox, causus rhombeatus and naja melanoleuca. | 2016 | 26743517 |
| tigecycline treatment experience against multidrug-resistant acinetobacter baumannii infections: a systematic review and meta-analysis. | the role of tigecycline in treating multidrug-resistant acinetobacter baumannii (mdr-ab) infections remains controversial. a systematic review and meta-analysis was performed to assess the efficacy and safety of tigecycline in treating mdr-ab infections. pubmed, embase and cochrane library databases were searched up to 20 september 2015. studies evaluating the efficacy and/or safety of tigecycline in treating mdr-ab infections were included. prisma guidelines were followed and the i(2) method wa ... | 2016 | 26742726 |
| antimicrobial activities of methanol, ethanol and supercritical co2 extracts of philippine piper betle l. on clinical isolates of gram positive and gram negative bacteria with transferable multiple drug resistance. | piper betle l. has traditionally been used in alternative medicine in different countries for various therapeutic purposes, including as an anti-infective agent. however, studies reported in the literature are mainly on its activities on drug susceptible bacterial strains. this study determined the antimicrobial activities of its ethanol, methanol, and supercritical co2 extracts on clinical isolates of multiple drug resistant bacteria which have been identified by the infectious disease society ... | 2016 | 26741962 |
| coexistence of blaoxa-23 with arma in quinolone-resistant acinetobacter baumannii from a chinese university hospital. | a total of 101 acinetobacter baumannii isolates were collected to determine the mechanisms of quinolone resistance and investigate the occurrence of carbapenem and high-level aminoglycoside resistance genes among quinolone-resistant strains. among 77 quinolone-resistant a. baumannii harbored mutations of gyra and parc, 41 isolates, which belonged to european clone ii, had resistance to aminoglycosides and carbapenems due to the expression of arma and acquisition of blaoxa-23. most of sequence ty ... | 2016 | 26740313 |
| association of doripenem resistance with oxa-type carbapenemases in acinetobacter baumannii isolates. | to evaluate the in vitro activity of doripenem in acinetobacter baumannii (a. baumannii) clinical isolates that possess different oxa-type carbapenemases, and to evaluate the roles of these enzymes in the development of carbapenem resistance. | 2016 | 26739973 |
| recovery of resistant bacteria from mattresses of patients under contact precautions. | microorganisms may contaminate hospital mattresses even after terminal cleaning. we investigated the recovery of resistant bacteria from the mattresses of patients under contact precautions at a university hospital. | 2016 | 26739639 |
| immunoprotective potential of in silico predicted acinetobacter baumannii outer membrane nuclease, nucab. | acinetobacter baumannii is an emerging multi-drug resistant pathogen causing significant mortality in hospitalized icu patients which demands developing new methods for prevention and treatment. a. baumannii 19606 proteome was analysed in silico through the online tool vaxign for finding potential vaccine candidates. the selected nuclease (nucab) was predicted to possess all the attributes of a promising vaccine candidate like outer membrane localization, high adhesin probability (0.53), one tra ... | 2016 | 26614015 |
| impact of rapid identification of acinetobacter baumannii via matrix-assisted laser desorption ionization time-of-flight mass spectrometry combined with antimicrobial stewardship in patients with pneumonia and/or bacteremia. | we evaluated the clinical and economic outcomes of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (maldi-tof ms) with stewardship intervention in patients with acinetobacter baumannii (ab) pneumonia and/or bacteremia. 66 patients were included in the pre-intervention group and 53 in the intervention group. the combination of ab identification via maldi-tof ms and id pharmd intervention significantly reduced the median time to effective therapy compared to convention ... | 2016 | 26603136 |
| molecular characterization and risk factors for carbapenem-resistant gram-negative bacilli colonization in children: emergence of ndm-producing acinetobacter baumannii in a newborn intensive care unit in turkey. | multidrug-resistant gram-negative bacilli are responsible for more than 50% of healthcare-associated infections. colonization dynamics, characteristics, and risk factor data for cr-gnb are scarce in children. | 2016 | 26601601 |
| in vitro activity of tigecycline against acinetobacter baumannii: global epidemiology and resistance mechanisms. | acinetobacter baumannii is a pathogen of increasing concern, commonly causing outbreaks in the hospital environment. of particular concern, a. baumannii strains exhibiting resistance to carbapenems, which were previously considered the treatment of choice for infected patients, have dramatically increased worldwide, leaving a few antibacterial choices. tigecycline, a broad-spectrum modified minocycline derivative, isconsidered as a last resort drug against multidrug-resistant a. baumannii. thoug ... | 2016 | 26563303 |
| effects of various antimicrobial stewardship programs on antimicrobial usage and resistance among common gram-negative bacilli causing health care-associated infections: a multicenter comparison. | the effects of various antimicrobial stewardship programs (asps) on both antibiotic consumption and resistance among different hospitals within the same insurance system have rarely been investigated. | 2016 | 26586483 |
| widespread dispersion of the resistance element tet(b)::iscr2 in xdr acinetobacter baumannii isolates. | acinetobacter baumannii is a significant nosocomial pathogen often associated with extreme drug resistance (xdr). in argentina, isolates of a. baumannii resistant to tetracyclines have accounted for more than 40% of drug-resistant isolates in some hospitals. we have previously reported the dispersion of the tet(b) resistance element associated with the iscr2 transposase in epidemiologically unrelated a. baumannii isolates recovered from 1983 to 2011. this study extends this surveillance to 77 re ... | 2016 | 26584648 |
| characterization of a novel acinetobacter baumannii xanthine dehydrogenase expressed in escherichia coli. | to characterize a novel xanthine dehydrogenase (xdh) from acinetobacter baumannii by recombinant expression in escherichia coli and to assess its potential for industrial applications. | 2016 | 26543035 |
| rapid detection of pseudomonas aeruginosa and acinetobacter baumannii harboring bla(vim-2), bla(imp-1) and bla(oxa-23) genes by using loop-mediated isothermal amplification methods. | carbapenem-resistant pseudomonas aeruginosa (crpa) and acinetobacter baumannii (crab) are the leading causes of nosocomial infections. a rapid and sensitive test to detect crpa and crab is required for appropriate antibiotic treatment. we optimized a loop-mediated isothermal amplification (lamp) assay to detect the presence of bla(vim-2), bla(imp-1), and bla(oxa-23), which are critical components for carbapenem resistance. | 2016 | 26522754 |
| biofilm formation and susceptibility to polymyxin b by a highly prevalent clone of multidrug-resistant acinetobacter baumannii from a mexican tertiary care hospital. | acinetobacter baumannii has emerged as a major cause of hospital-associated infections with increased morbidity and mortality among those affected. | 2016 | 26536333 |
| extensively drug-resistant acinetobacter baumannii in a lebanese intensive care unit: risk factors for acquisition and determination of a colonization score. | acinetobacter baumannii (ab) has emerged as an important nosocomial pathogen causing worldwide hospital outbreaks. it has become a prototype of extensively drug-resistant (xdr) organisms. | 2016 | 26616413 |
| characterization of ndm-1- and oxa-23-producing acinetobacter baumannii isolates from inanimate surfaces in a hospital environment in algeria. | investigation of several outbreaks of multidrug-resistant acinetobacter baumannii infection has demonstrated that contamination of the inanimate hospital environment could be implicated in the spread of these multidrug-resistant strains. | 2016 | 26615460 |
| national survey of thai infectious disease physicians on treatment of carbapenem-resistant acinetobacter baumannii ventilator-associated pneumonia: the role of infection control awareness. | objective to evaluate the expected and treatment outcomes of thai infectious disease physicians (idps) regarding carbapenem-resistant acinetobacter baumannii (crab) ventilator-associated pneumonia (vap) methods from june 1, 2014, to march 1, 2015, survey data regarding the expected and clinical success rates of crab vap treatment were collected from all thai idps. the expected success rate was defined as the expectation of clinical response after crab vap treatment for the given case scenario. c ... | 2016 | 26510383 |
| infectious cause of death determination using minimally invasive autopsies in developing countries. | in developing countries, the knowledge of the microorganisms causing fatal infections is critical and could help designing and implementing more effective preventive interventions and treatment guidelines. we aimed to develop and validate protocols for microbiological analysis in post-mortem samples obtained during minimally invasive autopsy (mia) procedures and to assess their performance. thirty mias performed in adults at maputo central hospital in southern mozambique were included in the ana ... | 2016 | 26508103 |
| comparative phosphoproteomics reveals the role of ampc β-lactamase phosphorylation in the clinical imipenem-resistant strain acinetobacter baumannii sk17. | nosocomial infectious outbreaks caused by multidrug-resistant acinetobacter baumannii have emerged as a serious threat to human health. phosphoproteomics of pathogenic bacteria has been used to identify the mechanisms of bacterial virulence and antimicrobial resistance. in this study, we used a shotgun strategy combined with high-accuracy mass spectrometry to analyze the phosphoproteomics of the imipenem-susceptible strain sk17-s and -resistant strain sk17-r. we identified 410 phosphosites on 24 ... | 2016 | 26499836 |
| antibiotic susceptibility of commensal bacteria from human milk. | recent studies have focused on foodborne or commensal bacteria as vehicles of antibiotic resistance. however, the antibiotic resistance of milk bacteria from healthy donors is still vague in taiwan. for this purpose, human milk samples were obtained from randomly recruited 19 healthy women between 3 and 360 days post-partum. antibiotic susceptibility profile of bacteria from milk samples was determined. about 20 bacterial species were isolated from milk samples including staphylococcus (6 specie ... | 2016 | 26494365 |
| measures to eradicate multidrug-resistant organism outbreaks: how much do they cost? | this study aimed to assess the economic burden of infection control measures that succeeded in eradicating multidrug-resistant organisms (mdros) in emerging epidemic contexts in hospital settings. the medline, embase and ovid databases were systematically interrogated for original english-language articles detailing costs associated with strict measures to eradicate mdros published between 1 january 1974 and 2 november 2014. this study was conducted in accordance with the preferred reporting ite ... | 2016 | 26482264 |
| antibiofilm agents against mdr bacterial strains: is bioactive glass bag-s53p4 also effective? | the treatment of bone and joint infections is challenging due to the presence of bacterial biofilm and the increasing emergence of multiresistant strains. bag-s53p4 is a bone substitute that is characterized by osteoconductive and antimicrobial properties. the aim of this study was to assess the effectiveness of bag-s53p4 against biofilm produced in vitro by multiresistant bacterial strains. | 2016 | 26462989 |
| amide side chain amphiphilic polymers disrupt surface established bacterial bio-films and protect mice from chronic acinetobacter baumannii infection. | bacterial biofilms represent the root-cause of chronic or persistent infections in humans. gram-negative bacterial infections due to nosocomial and opportunistic pathogens such as acinetobacter baumannii are more difficult to treat because of their inherent and rapidly acquiring resistance to antibiotics. due to biofilm formation, a. baumannii has been noted for its apparent ability to survive on artificial surfaces for an extended period of time, therefore allowing it to persist in the hospital ... | 2016 | 26454051 |
| in vivo activity of vancomycin combined with colistin against multidrug-resistant strains of acinetobacter baumannii in a galleria mellonella model. | with increasing antibiotic resistance, the selection of effective treatment of a. baumannii infections is particularly challenging. | 2016 | 26503239 |
| prevalence and molecular characterization of carbapenemase-producing gram-negative bacteria from a university hospital in china. | the increasing emergence of carbapenem resistance in gram-negative bacteria associated with carbapenemase prompted the initiation of this study. | 2016 | 26463362 |
| comparison of the virulence-associated phenotypes of five species of acinetobacter baumannii complex. | in this study, we compared the virulence-associated factors of acinetobacter baumannii complex species. sixty-three isolates of five a. baumannii complex species, including 19 a. baumannii, 15 a. nosocomialis, 13 a. seifertii, 13 a. pittii, and 3 a. calcoaceticus isolates, were included in this study. for all isolates, biofilm formation, a549 cell adherence, resistance to normal human serum, and motility were evaluated. a. baumannii complex isolates showed diversity in biofilm formation, a549 ce ... | 2016 | 26428730 |
| rapid and sensitive detection of carbapenemase activity in acinetobacter baumannii using superficially porous liquid chromatography-tandem mass spectrometry. | the emergence and spread of carbapenem-resistant acinetobacter baumannii poses a challenge for optimizing antibiotic therapies and preventing outbreaks. traditional phenotypic assays such as the modified hodge test (mht) or polymerase chain reaction (pcr)-based detection of the carbapenemase genes are time-consuming and complicated. therefore, new approaches for the efficient detection of carbapenemase-producing a. baumannii are urgently required. | 2016 | 26420036 |
| bayesian framework for parametric bivariate accelerated lifetime modeling and its application to hospital acquired infections. | infectious diseases that can be spread directly or indirectly from one person to another are caused by pathogenic microorganisms such as bacteria, viruses, parasites, or fungi. infectious diseases remain one of the greatest threats to human health and the analysis of infectious disease data is among the most important application of statistics. in this article, we develop bayesian methodology using parametric bivariate accelerated lifetime model to study dependency between the colonization and i ... | 2016 | 26394029 |
| gipsy: genomic island prediction software. | bacteria are highly diverse organisms that are able to adapt to a broad range of environments and hosts due to their high genomic plasticity. horizontal gene transfer plays a pivotal role in this genome plasticity and in evolution by leaps through the incorporation of large blocks of genome sequences, ordinarily known as genomic islands (geis). geis may harbor genes encoding virulence, metabolism, antibiotic resistance and symbiosis-related functions, namely pathogenicity islands (pais), metabol ... | 2016 | 26376473 |
| in vitro activity of aminoglycosides against clinical isolates of acinetobacter baumannii complex and other nonfermentative gram-negative bacilli causing healthcare-associated bloodstream infections in taiwan. | aminoglycosides possess in vitro activity against aerobic and facultative gram-negative bacilli. however, nationwide surveillance on susceptibility data of acinetobacter baumannii complex and pseudomonas aeruginosa to aminoglycosides was limited, and aminoglycoside resistance has emerged in the past decade. we study the in vitro susceptibility of a. baumannii complex and other nonfermentative gram-negative bacilli (nfgnb) to aminoglycosides. | 2016 | 26364729 |
| secular trends in acinetobacter baumannii resistance in respiratory and blood stream specimens in the united states, 2003 to 2012: a survey study. | acinetobacter baumannii (ab) has evolved a variety of resistance mechanisms and exhibits unpredictable susceptibility patterns, making it difficult to select empiric therapy. | 2016 | 26353076 |
| comparison of the clinical efficacy between tigecycline plus extended-infusion imipenem and sulbactam plus imipenem against ventilator-associated pneumonia with pneumonic extensively drug-resistant acinetobacter baumannii bacteremia, and correlation of clinical efficacy with in vitro synergy tests. | to compare the clinical efficacy between salvage antimicrobial regimen consisting of tigecycline plus extended-infusion imipenem/cilastatin (tic) and regimen of sulbactam plus imipenem/cilastatin (sic) for patients with ventilator-associated pneumonia and pneumonic bacteremia due to extensively drug-resistant (xdr) acinetobacter baumannii (ab) isolates, and determine the correlation of results of in vitro tigecycline-imipenem synergy test with clinical efficacy. | 2016 | 26341302 |
| postantibiotic effect of colistin alone and combined with vancomycin or meropenem against acinetobacter spp. with well defined resistance mechanisms. | previous studies found short postantibiotic effect of colistin on acinetobacter baumannii. many studies have evaluated the potential for synergy between colistin and other antibiotics against a. baumannii. the aim of this study was to determine in vitro synergy and postantibiotic effect (pae) of colistin alone and combined with other antibiotics (vancomycin or meropenem) against eight carbapenem-non-susceptible acinetobacter spp. strains with defined resistance mechanisms. it was hypothesised th ... | 2016 | 26319682 |
| polyvinyl alcohol nanofiber formulation of the designer antimicrobial peptide apo sterilizes acinetobacter baumannii-infected skin wounds in mice. | native and designer cationic antimicrobial peptides are increasingly acknowledged as host defense molecules rather than true antimicrobials. due to their ability to activate the innate immune system, these structures are used to treat uninfected and bacterially-infected wounds, including those harboring acinetobacter baumannii. previously we documented that when administered intramuscularly or topically in liquid formulations, the proline-rich host defense peptide dimer a3-apo accelerates uninfe ... | 2016 | 26319645 |
| oxa-carbapenemases present in clinical acinetobacter baumannii-calcoaceticus complex isolates from patients in kurdistan region, iraq. | in addition to intrinsic resistance in acinetobacter baumannii, many different types of acquired resistance mechanisms have been reported, including the presence of vim and imp metallo β-lactamases and also of blaoxa-23-like and blaoxa-58-like enzymes. in the kurdistan region of iraq, the multiresistant a. baumannii-calcoaceticus complex is prevalent. we characterized the different mechanisms of resistance present in clinical isolates collected from different wards and different hospitals from t ... | 2016 | 27003287 |
| effects of saline, an ambient acidic environment, and sodium salicylate on oxa-mediated carbapenem resistance in acinetobacter baumannii. | different physiological conditions, such as nacl, low ph, and sodium salicylate, have been shown to affect antibiotic resistance determinants in acinetobacter baumannii isolates. therefore, the aim of this study was to investigate the effects of nacl, sodium salicylate, and low ph on the susceptibility of a. baumannii to carbapenem. we cloned genes encoding oxacillinases (oxa) of different subclasses, with their associated promoters, from carbapenem-resistant a. baumannii isolates into the same ... | 2016 | 27001819 |
| candida albicans airway colonization facilitates subsequent acinetobacter baumannii pneumonia in a rat model. | the objective of the study was to determine the effects of candida albicans respiratory tract colonization on acinetobacter baumannii pneumonia in a rat model. rats were colonized with c. albicans by instillation of 3 × 10(6) cfu into their airways, while sterile saline was instilled in the control group. the colonized rats were further divided into two groups: treated with amphotericin b or not. the rats were subsequently infected with a. baumannii (10(8) cfu by tracheobronchial instillation). ... | 2016 | 27001817 |
| candida spp. airway colonization: a potential risk factor for acinetobacter baumannii ventilator-associated pneumonia. | this retrospective study was conducted to identify potential risk factors for acinetobacter baumannii (a. baumannii) ventilator-associated pneumonia (vap) and evaluate the association between candida spp. airway colonization and a. baumannii vap. intensive care unit (icu) patients who were on mechanical ventilation (mv) for ≥48 hours were divided into the following groups: patients with and without candida spp. airway colonization; colonized patients receiving antifungal treatment or not; patien ... | 2016 | 27001670 |
| resistance trends among clinical isolates in china reported from chinet surveillance of bacterial resistance, 2005-2014. | with the aim of gathering temporal trends on bacterial epidemiology and resistance from multiple laboratories in china, the chinet surveillance system was organized in 2005. antimicrobial susceptibility testing was carried out according to a unified protocol using the kirby-bauer method or automated systems. results were analyzed according to clinical and laboratory standards institute (clsi) 2014 definitions. between 2005 and 2014, the number of bacterial isolates ranged between 22,774 and 84,5 ... | 2016 | 27000156 |
| antimicrobial combinations against pan-resistant acinetobacter baumannii isolates with different resistance mechanisms. | the study investigated the effect of antibiotic combinations against 20 clinical isolates of a. baumannii (seven colistin-resistant and 13 colistin-susceptible) with different resistance mechanisms. clinical data, treatment, and patient mortality were evaluated. the following methods were used: mic, pcrs, and outer membrane protein (omp) analysis. synergy was investigated using the checkerboard and time-kill methods. clonality was evaluated by pfge. based on clonality, the whole genome sequence ... | 2016 | 26998609 |
| liver cirrhosis and diabetes mellitus are risk factors for staphylococcus aureus infection in patients with healthcare-associated or hospital-acquired pneumonia. | the risk factors for staphylococcus aureus (s. aureus) pneumonia are not fully identified. the aim of this work was to find out the clinical characteristics associated with s. aureus infection in patients with healthcare-associated pneumonia (hcap) and hospital-acquired pneumonia (hap), which may be applicable for more appropriate selection of empiric antibiotic therapy. | 2016 | 26998356 |
| antibacterial low molecular weight cationic polymers: dissecting the contribution of hydrophobicity, chain length and charge to activity. | the balance of cationicity and hydrophobicity can profoundly affect the performance of antimicrobial polymers. to this end a library of 24 cationic polymers with uniquely low degrees of polymerization was synthesized via cu(0)-mediated polymerization, using three different cationic monomers and two initiators: providing two different hydrocarbon chain tail lengths (c2 and c12). the polymers exhibited structure-dependent antibacterial activity when tested against a selection of bacteria, viz, sta ... | 2016 | 26998253 |
| case report: real-time contrast-enhanced ultrasonography for the diagnosis of typical 'bull's eye' sign of hepatic abscess caused by acinetobacter baumannii in a tumor patient. | the present case report details a unique case of a 51-year-old male patient who underwent a radical operation for carcinoma of the stomach and pancreaticoduodenectomy. conventional ultrasonography examination exhibited a characteristic 'bull's eye' sign in the liver; whereas real-time contrast-enhanced ultrasonography (ceus) demonstrated the patient was suffering from a hepatic abscess, corroborated by cytologic examination, which confirmed the presence of acinetobacter baumannii. the hepatic lo ... | 2016 | 26998014 |
| a three-year survey of the antimicrobial resistance of microorganisms at a chinese hospital. | the present retrospective study aimed to investigate the antibiotic susceptibility of bacteria at shanghai first people's hospital (shanghai, china) between 2009 and 2011. an increasing trend of antibiotic resistance was observed in this hospital between 2009 and 2011. escherichia coli, acinetobacter baumannii and staphylococcus aureus were the most prevalent resistant strains. antimicrobial susceptibility was detected using standard kirby-bauer disk diffusion and analyzed using world health org ... | 2016 | 26997986 |
| blood stream infections caused by acinetobacter baumannii group in japan - epidemiological and clinical investigation. | acinetobacter calcoaceticus-acinetobacter baumannii complex, especially a. baumannii, acinetobacter pittii and acinetobacter nosocomialis, constitutes an important group of nosocomial pathogens; however, epidemiological or clinical characteristics and prognosis is limited in japan. from 2009 to 2013, 47 blood stream infection cases resulting from a. baumannii group were reviewed at the national defense medical college, an 800-bed tertiary hospital. to determine the genospecies, further comparati ... | 2016 | 26993173 |
| characterization and complete genome sequence analysis of two myoviral bacteriophages infecting clinical carbapenem-resistant acinetobacter baumannii isolates. | the aim of this study was to characterize phenotypical properties, to analyse whole genomes of novel acinetobacter baumannii phages infecting carbapenem-resistant ac. baumannii (crab) and to evaluate their potential as antimicrobial alternatives to control ac. baumannii in clinical settings. | 2016 | 26991925 |
| epidemic dissemination of a carbapenem-resistant acinetobacter baumannii clone carrying arma two years after its first isolation in an italian hospital. | this study describes the dissemination of a carbapenem-resistant acinetobacter baumannii (crab) strain in a university hospital in northeast italy. characterization of the outbreak strain was combined with a retrospective analysis of all crab isolates collected in the same hospital during the 5 years preceding the outbreak, with the aim of elucidating the origin of the epidemic spread. the outbreak strain was shown to belong to the international clone ii and carry the blaoxa-23 gene, flanked by ... | 2016 | 26990617 |
| complete genome sequence of acinetobacter baumannii xh386 (st208), a multi-drug resistant bacteria isolated from pediatric hospital in china. | acinetobacter baumannii is an important bacterium that emerged as a significant nosocomial pathogen worldwide. the rise of a. baumannii was due to its multi-drug resistance (mdr), while it was difficult to treat multi-drug resistant a. baumannii with antibiotics, especially in pediatric patients for the therapeutic options with antibiotics were quite limited in pediatric patients. a. baumannii st208 was identified as predominant sequence type of carbapenem resistant a. baumannii in the united st ... | 2016 | 26981403 |
| acinetobacter baumannii infection and il-17 mediated immunity. | acinetobacter baumannii is a significant cause of severe hospital-acquired infections with a recent rise in multidrug-resistant infections involving traumatic wounds of military personnel. the interleukin-17 (il-17) pathway is essential for neutrophil recruitment in response to a variety of pathogens, while the control of a. baumannii infection is known to be dependent on neutrophils. this suggests that il-17 may play an important role in a. baumannii infection; however, this has yet to be studi ... | 2016 | 26977122 |
| pilot screening to determine antimicrobial synergies in a multidrug-resistant bacterial strain library. | with the rise in multidrug-resistant (mdr) bacterial infections, there has been increasing interest in combinations of ≥2 antimicrobial agents with synergistic effects. we established an mdr bacterial strain library to screen for in vitro antimicrobial synergy by using a broth microdilution checkerboard method and high-throughput luciferase-based bacterial cell viability assay. in total, 39 mdr bacterial strains, including 23 carbapenem-resistant gram-negative bacteria, 9 vancomycin-intermediate ... | 2016 | 26974861 |
| identification of an inhibitor of the aminoglycoside 6'-n-acetyltransferase type ib [aac(6')-ib] by glide molecular docking. | the aminoglycoside 6'-n-acetyltransferase type ib, aac(6')-ib, confers resistance to clinically relevant aminoglycosides and is the most widely distributed enzyme among aac(6')-i-producing gram-negative pathogens. an alternative to counter the action of this enzyme is the development of inhibitors. glide is a computational strategy for rapidly docking ligands to protein sites and estimating their binding affinities. we docked a collection of 280,000 compounds from 7 sub-libraries of the chembrid ... | 2016 | 26973774 |
| diversity of mechanisms conferring resistance to β-lactams among oxa-23-producing acinetobacter baumannii clones. | a total of 31 unrelated oxa-23-producing acinetobacter baumannii strains isolated from 14 hospitals located in distinct brazilian regions were evaluated in this study. these isolates were grouped into 12 different sequence types (sts), of which 7 had unique allelic sequences (st188, st189, st190, st191, st192, st228, and st299). most isolates belonged to the clonal complex cc79 followed by cc15 and cc1. only polymyxin b and minocycline showed good activity against the oxa-23-producing a. baumann ... | 2016 | 26971181 |
| antibiotic-resistant acinetobacter baumannii increasing success remains a challenge as a nosocomial pathogen. | antibiotic-resistant infectious bacteria currently imply a high risk and therefore constitute a strong challenge when treating patients in hospital settings. characterization of these species and of particular strains is a priority for the establishment of diagnostic tests and preventive procedures. the relevance of acinetobacter baumannii as a problematic microorganism in inpatient facilities, particularly intensive care units, has increased over time. this review aims to draw attention to (i) ... | 2016 | 26966582 |
| urinary tract infections in intensive care unit patients - a single-centre, 3-year observational study according to the inicc project. | urinary tract infections (uti) in patients with urinary catheters could be a serious complication of hospitalisation in the intensive care unit (icu). | 2016 | 26966105 |
| kisameet clay isolated from the central coast of british columbia, canada, demonstrates broad-spectrum antimicrobial activity. | clay minerals are naturally occurring layered phyllosilicates which consist of fine particles and possess antimicrobial activity. in a recent article, behroozian et al. obtained kisameet clay (kc) from kisameet, from the central coast of british columbia, canada, northwest of vancouver and assessed its antimicrobial activity versus 16 selected eskape pathogens (enterococcus faecium, staphylococcus aureus, klebsiella pneumoniae, acinetobacter baumannii, pseudomonas aeruginosa, and enterobacter sp ... | 2016 | 26956585 |
| outbreak caused by blaoxa-72-producing acinetobacter baumannii st417 detected in clinical and environmental isolates. | we characterized an outbreak of imipenem-resistant acinetobacter baumannii with clinical and environmental isolates from a tertiary care hospital in san luis potosi, mexico. during a 4-month period, a total of 32 nonrepetitive imipenem-resistant clinical isolates of a. baumannii were collected. all isolates were susceptible to colistin and tigecycline and resistant to cefepime, ceftazidime, ceftriaxone, imipenem, and meropenem. genotyping by pulsed-field gel electrophoresis showed a major clone ... | 2016 | 26954369 |
| effects of efflux pump inhibitors on colistin resistance in multidrug-resistant gram-negative bacteria. | we tested the effects of various putative efflux pump inhibitors on colistin resistance in multidrug-resistant gram-negative bacteria. addition of 10 mg/liter cyanide 3-chlorophenylhydrazone (cccp) to the test medium could significantly decrease the mics of colistin-resistant strains. time-kill assays showed cccp could reverse colistin resistance and inhibit the regrowth of the resistant subpopulation, especially in acinetobacter baumannii and stenotrophomonas maltophilia these results suggest c ... | 2016 | 26953203 |
| intraspecies transfer of the chromosomal acinetobacter baumannii blandm-1 carbapenemase gene. | the species acinetobacter baumannii is one of the most important multidrug-resistant human pathogens. to determine its virulence and antibiotic resistance determinants, the genome of the nosocomial blandm-1-positive a. baumannii strain r2090 originating from egypt was completely sequenced. genome analysis revealed that strain r2090 is highly related to the community-acquired australian a. baumannii strain d1279779. the two strains belong to sequence type 267 (st267). isolate r2090 harbored the c ... | 2016 | 26953198 |
| protective effect of a synbiotic against multidrug-resistant acinetobacter baumannii in a murine infection model. | this study investigated the ability of the probiotic bifidobacterium breve strain yakult (bby) to protect against infection, as well as the potentiation of bby activity by the synbiotic combination of bby and prebiotic galactooligosaccharides (gos). the study employed a mouse model of lethal intestinal multidrug-resistant acinetobacter baumannii (mdrab) infection. the endogenous intestinal microbiota was disrupted by the administration of multiple antibiotics, causing the loss of endogenous bifi ... | 2016 | 26953197 |
| risk factors and clinical outcomes for patients with acinetobacter baumannii bacteremia. | acinetobacter (a.) baumannii, an opportunistic nosocomial pathogen that can cause significant morbidity and mortality, has emerged as a worldwide problem. this study aimed to analyze the clinical features and outcomes of patients with a. baumannii bacteremia and determine the factors influencing survival by using 14-day mortality as the primary endpoint. a 6-year retrospective study of 122 cases with monomicrobial a. baumannii bacteremia was conducted in chinese people's liberation army (pla) ge ... | 2016 | 26945403 |
| acinetobacter seifertii isolated from china: genomic sequence and molecular epidemiology analyses. | clinical infections caused by acinetobacter spp. have increasing public health concerns because of their global occurrence and ability to acquire multidrug resistance. acinetobacter calcoaceticus-acinetobacter baumannii (acb) complex encompasses a. calcoaceticus, a. baumannii, a. pittii (formerly genomic species 3), and a nosocomial (formerly genomic species 13tu), which are predominantly responsible for clinical pathogenesis in the acinetobacter genus. in our previous study, a putative novel sp ... | 2016 | 26945401 |
| the resistance gene complement of d4, a multiply antibiotic-resistant st25 acinetobacter baumannii isolate, resides in two genomic islands and a plasmid. | 2016 | 26944923 | |
| draft genome sequence of acinetobacter baumannii iitr88, a bacterium degrading indoles and other aromatic compounds. | here, we report the 4.16-mb draft genome sequence of an indole-degrading bacterium, acinetobacter baumannii iitr88, isolated from the bhagirathi river in india. a total of 4,069 coding regions (cdss), 3 rrnas, and 52 trnas were predicted. genes for the degradation of indoles, phenylacetaldehyde, anthranilate, and several other aromatic compounds were present. | 2016 | 26941147 |
| genome dynamics of multidrug-resistant acinetobacter baumannii during infection and treatment. | limited treatment options are available for patients infected with multidrug (mdr)- or pan-drug (pdr)-resistant bacterial pathogens, resulting in infections that can persist for weeks or months. in order to better understand transmission and evolutionary dynamics of mdr acinetobacter baumannii (ab) during long-term infection, we analyzed genomes from a series of isolates from individual patients at isolate-specific, patient-specific, and population levels. | 2016 | 26939581 |