Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| epidemiological study of prevalence, determinants, and outcomes of infections in medical icu at a tertiary care hospital in india. | to determine the prevalence of infections, risk factors, and outcomes in a medical intensive care unit (icu), we performed a hospital-based study. | 2017 | 26628756 |
| clinical and microbiological characteristics of bloodstream infections among patients with haematological malignancies with and without neutropenia at a medical centre in northern taiwan, 2008-2013. | this study aimed to investigate the epidemiology and microbiology of bloodstream infections (bsis) in patients with haematological malignancies. clinical characteristics and microbiology of 2083 patients with haematological malignancy who were treated for bsi from 2008 to 2013 at a medical centre in taiwan were retrospectively reviewed. lymphoma (38.1%) was the most common, followed by acute myeloid leukaemia (30.9%). of the 2090 non-duplicate bsi isolates, 1310 (62.7%) were recovered from patie ... | 2017 | 28109554 |
| the role of maxillary sinus puncture on the diagnosis and treatment of patients with hospital-acquired rhinosinusitis. | rhinosinusitis is one of the most common causes of fever of unknown origin in critically ill patients and should be systematically searched. | 2017 | 22936134 |
| identification of bacteria in blood cultures from clinically ill captive antillean manatees (trichechus manatus manatus). | between september 2001 and march 2013, 62 bacterial cultures (37 aerobic and 25 anaerobic) were performed on 37 blood samples from 23 antillean manatees ( trichechus manatus manatus) that were kept in captivity at the brazilian national center for research and conservation of aquatic mammals (cma) in pernambuco (cma-pe) and alagoas (cma-al), brazil. all of the animals sampled exhibited clinical signs at the time of sampling including abscesses (n = 8), debilitation and anorexia (n = 22), and pro ... | 2017 | 28363079 |
| secondary bacterial isolates from previously untreated buruli ulcer lesions and their antibiotic susceptibility patterns in southern nigeria. | mycolactones, secreted by mycobacterium ulcerans, were previously believed to prevent super infection in buruli ulcer lesions. however, little is known about secondary bacterial infections in these lesions. this study evaluated contaminating bacterial flora and their antibiotic susceptibility patterns in cases of previously untreated buruli ulcer disease from three states in southern nigeria. | 2017 | 28001222 |
| bacteriophage remediation of bacterial pathogens in aquaculture: a review of the technology. | bacteriophages have been proposed as an alternative to antibiotic usage and several studies on their application in aquaculture have been reported. this review highlights progress to date on phage therapies for the following fish and shellfish diseases and associated pathogens: hemorrhagic septicemia (aeromonas hydrophila) in loaches, furunculosis (aeromonas salmonicida) in trout and salmon, edwardsiellosis (edwardsiella tarda) in eel, columnaris disease (flavobacterium columnare) in catfish, ra ... | 2017 | 26713223 |
| gram-negative osteomyelitis: clinical and microbiological profile. | despite the growing interest in the study of gram-negative bacilli (gnb) infections, very little information on osteomyelitis caused by gnb is available in the medical literature. | 2017 | 22358358 |
| synthesis and antimicrobial properties of 4-acylaminobenzenethiosulfoacid s-esters. | a series of esters of 4-acetyl, 4-trifluoroacetyl- and 4-(3-chloropropionyl)aminobenzenethiosulfoacids (twenty-four compounds) were synthesized and characterized by elemental analysis, (1)h nmr and ir spectroscopy. the antibacterial activity of the novel candidates has been screened using the agar diffusion or serial dilution methods against representative gram-positive (staphylococcus aureus, bacillus subtilis, bacillus mesentericus, mycobacterium sp., mycobacterium luteum), gram-negative (aero ... | 2017 | 28344478 |
| rhamnolipids from non-pathogenic burkholderia thailandensis e264: physicochemical characterization, antimicrobial and antibiofilm efficacy against oral hygiene related pathogens. | biosurfactants are naturally occurring surface active compounds that have mainly been exploited for environmental applications and consumer products, with their biomedical efficacy an emerging area of research. rhamnolipids area major group of biosurfactants that have been reported for their antimicrobial and antibiofilm efficacy. one of the main limiting factors for scaled up production and downstream applications of rhamnolipids is the fact that they are predominantly produced from the opportu ... | 2017 | 28065676 |
| bacterial coaggregation among the most commonly isolated bacteria from contact lens cases. | to examine the coaggregation and cohesion between the commonly isolated bacteria from contact lens cases. | 2017 | 28061510 |
| antimicrobial metal-based thiophene derived compounds. | a novel series of thiophene derived schiff bases and their transition metal- [co(ii), cu(ii), zn(ii), ni(ii)] based compounds are reported. the schiff bases act as tridentate ligands toward metal ions via azomethine-n, deprotonated-n of ammine substituents and s-atom of thienyl moiety. the synthesized ligands along with their metal complexes were screened for their in vitro antibacterial activity against six bacterial pathogens (escherichia coli, shigella flexneri, pseudomonas aeruginosa, salmon ... | 2017 | 27766891 |
| design, synthesis and spectroscopic characterization of metal (ii) complexes derived from a tetradentate macrocyclic ligand: study on antimicrobial and antioxidant capacity of complexes. | the paper presents the synthesis of co(ii), ni(ii) and cu(ii) complexes of macrocyclic schiff base ligand derived from 1, 4-dicarbonyl-phenyl-dihydrazide and ethyl 3-oxobutanoate (2:2). the synthesized ligand and its metal complexes were characterized by elemental analyses, magnetic susceptibility measurements, ftir, uv-vis., mass (1)h nmr and x-ray diffraction. the cu(ii) complex exhibit distorted octahedral geometry, whereas an octahedral geometry is suggested for other complexes. the synthesi ... | 2017 | 28126666 |
| the effect of tobramycin incorporated with bismuth-ethanedithiol loaded on niosomes on the quorum sensing and biofilm formation of pseudomonas aeruginosa. | pseudomonas aeruginosa is an opportunistic pathogen, enable of causing infections especially in immunocompromised patients. recently many isolates developed multiple drug resistance, resulting in treatment failure in serious infections. in this study, the effect of tobramycin incorporated with bismuth-ethanedithiol loaded on niosomes on the quorum sensing and biofilm production by p. aeruginosa was evaluated. thin layer hydration method with cholesterol (30%), span 40 and tween 40 were used to m ... | 2017 | 28323149 |
| penicillin v acylases from gram-negative bacteria degrade n-acylhomoserine lactones and attenuate virulence in pseudomonas aeruginosa. | virulence pathways in gram-negative pathogenic bacteria are regulated by quorum sensing mechanisms, through the production and sensing of n-acylhomoserine lactone (ahl) signal molecules. enzymatic degradation of ahls leading to attenuation of virulence (quorum quenching) could pave the way for the development of new antibacterials. penicillin v acylases (pvas) belong to the ntn hydrolase superfamily, together with ahl acylases. pvas are exploited widely in the pharmaceutical industry, but their ... | 2017 | 27933456 |
| household proximity to water and nontuberculous mycobacteria in children with cystic fibrosis. | nontuberculous mycobacteria (ntm) have a particular affinity for patients with cystic fibrosis (cf). recent studies suggest a possible relationship between acquiring ntm and the level of environmental water in a given area. we sought to determine if there is an association between household proximity to water and ntm in children with cf. | 2017 | 28135043 |
| synthesis and biological evaluation of newer 1,3,4-oxadiazoles incorporated with benzothiazepine and benzodiazepine moieties. | a series of thiazepines and diazepines having 1,3,4-oxadiazole moiety were synthesized, and they were analyzed for their in vitro antimicrobial activity against several bacteria (staphylococcus aureus, staphylococcus pyogenes, escherichia coli, and pseudomonas aeruginosa) and fungi (candida albicans, aspergillus niger, and aspergillus clavatus) and protozoa (entamoeba histolytica, giardia lamblia, trypanosoma cruzi and leishmania mexicana). few of the selected compounds were tested for their ant ... | 2017 | 28182579 |
| dirhamnolipids secreted from pseudomonas aeruginosa modify anjpegungal susceptibility of aspergillus fumigatus by inhibiting β1,3 glucan synthase activity. | pseudomonas aeruginosa and aspergillus fumigatus are the two microorganisms responsible for most of the chronic infections in cystic fibrosis patients. p. aeruginosa is known to produce quorum-sensing controlled rhamnolipids during chronic infections. here we show that the dirhamnolipids secreted from p. aeruginosa (i) induce a. fumigatus to produce an extracellular matrix, rich in galactosaminogalactan, 1,8-dihydroxynaphthalene (dhn)- and pyo-melanin, surrounding their hyphae, which facilitates ... | 2017 | 28338676 |
| epidemiology of multidrug-resistant gram-negative pathogens isolated from ventilator-associated pneumonia in icu patients. | antibiotic resistance among gram-negative pathogens isolated from ventilator-associated pneumonia (vap) poses a grave threat in intensive care unit (icu) patients. the aim of this study was to assess the prevalence of pathogens in icu patients and their drug resistance profile. the prevalence of extended-spectrum β-lactamases (esbls), ampc β-lactamases and metallo-β-lactamases (mbls) was also assessed. | 2017 | 28288860 |
| phytochemical and cytogenetic characterization of centaurea solstitialis l. (asteraceae) from croatia. | the cytogenetic characterization of centaurea solstitialis l. (asteraceae) showed a chromosome number of 2n = 16. karyotype is composed by four pairs of metacentric, two pairs of submetacentric and two pairs of subtelocentric chromosomes. physical mapping of two rdna probes revealed two loci of 35s and one locus of 5s rrna genes. chromomycin fluorochrome banding revealed that all rdna loci were gc rich. the genome size (2c-value) of 1.95 pg classes this species in the group of very small genomes ... | 2017 | 27552682 |
| are cystic fibrosis aspergillus fumigatus isolates different? intermicrobial interactions with pseudomonas. | pseudomonas aeruginosa and aspergillus fumigatus are the leading bacterial and fungal pathogens in cystic fibrosis (cf). we have shown that af biofilms are susceptible to pseudomonas, particularly cf phenotypes. those studies were performed with a reference virulent non-cf aspergillus. pseudomonas resident in cf airways undergo profound genetic and phenotypic adaptations to the abnormal environment. studies have also indicated aspergillus from cf patients have unexpected profiles of antifungal s ... | 2017 | 27822731 |
| chemical characteristics, antimicrobial and cytotoxic activities of the essential oil of egyptian cinnamomum glanduliferum bark. | the essential oil isolated from the bark of cinnamomum glanduliferum (wall) meissn that grown in egypt was screened for the first time. the chemical composition was analyzed by gc and gc/mass. the antimicrobial activity of the oil was assessed using agar-well diffusion method toward representatives for each of gram-positive bacteria, gram-negative bacteria, and fungi. the cytotoxic activity was checked using three human cancer cell lines. twenty seven compounds were identified, representing 99.0 ... | 2017 | 28190283 |
| synthetic cystic fibrosis sputum medium diminishes <i>burkholderia cenocepacia</i> antifungal activity against <i>aspergillus fumigatus</i> independently of phenylacetic acid production. | phenylacetic acid (paa), an intermediate of phenylalanine degradation, is emerging as a signal molecule in microbial interactions with the host. in this work, we explore the presence of phenylalanine and paa catabolism in three microbial pathogens of the cystic fibrosis (cf) lung microbiome: <i>pseudomonas aeruginosa</i>, <i>burkholderia cenocepacia</i> and <i>aspergillus fumigatus</i>. while <i>in silico</i> analysis of <i>b. cenocepacia</i> j2315 and <i>a. fumigatus</i> af293 genome sequences ... | 2017 | 28178425 |
| prospective multicenter german study on pulmonary colonization with scedosporium /lomentospora species in cystic fibrosis: epidemiology and new association factors. | an increasing rate of respiratory colonization and infection in cystic fibrosis (cf) is caused by fungi of the scedosporium apiospermum species complex or lomentospora prolificans (sac-lp). these fungi rank second among the filamentous fungi colonizing the cf airways, after aspergillus fumigatus. however, the epidemiology, clinical relevance and risk of pulmonary colonization with sac-lp are rarely understood in cf. the objective of the present prospective multicenter study was to study pathogen ... | 2017 | 28178337 |
| effect of anaerobiasis or hypoxia on pseudomonas aeruginosa inhibition of aspergillus fumigatus biofilm. | pseudomonas aeruginosa (pa) and aspergillus fumigatus (af) are the major bacterial and fungal pathogens in the airways of cystic fibrosis (cf) patients. this is likely related to their ability to form biofilms. both microbes have been associated with cf disease progression. the interplay between these two pathogens has been studied under aerobic conditions, though accumulating data indicates that much of the cf airway is hypoxic or anaerobic. we studied the microbial interaction in these latter ... | 2017 | 28357473 |
| bactericidal and fungicidal activity of n-chlorotaurine is enhanced in cystic fibrosis sputum medium. | lung infections with multiresistant pathogens are a major problem of patients suffering from cystic fibrosis (cf). n-chlorotaurine (nct), a microbicidal active chlorine compound with no resistance development, is well tolerated upon inhalation. the aim of this study was to investigate nct on its bactericidal and fungicidal activity in vitro in artificial sputum medium (asm) mimicking the composition of cystic fibrosis mucus.the medium was inoculated with bacteria (staphylococcus aureus including ... | 2017 | 28223376 |
| n-heterocyclic choline analogues based on 1,2,3,4-tetrahydro(iso)quinoline scaffold with anticancer and anti-infective dual action. | pharmacological effects of biologically active "small molecules" can be improved by their targeted modification, which affects drug delivery and interaction with tumor cells and microorganisms. we aimed to evaluate anticancer and antimicrobial activity of lipid-like choline derivatives modified via simultaneous introduction of tetrahydro(iso)quinoline based pharmacophore system at nitrogen atom and long chain alkyl substituent at oxygen atom. | 2017 | 28364698 |
| isolation and characterisation of an enterocin p-producing enterococcus lactis strain from a fresh shrimp (penaeus vannamei). | screening for lactic acid bacteria (lab) from fresh shrimp samples (penaeus vannamei) collected from retail seafood markets in the tunisian's coast, resulted in the isolation of an enterococcus strain termed q1. this strain was selected for its antagonistic activity against pathogenic bacteria such as listeria monocytogenes, pseudomonas aeruginosa, lactococcus garvieae and against fungi (aspergillus niger and fusarium equiseti). the q1 strain was characterised using standard morphological and bi ... | 2017 | 28265787 |
| effects of potassium sulfate [k2so4] on the element contents, polyphenol content, antioxidant and antimicrobial activities of milk thistle [silybum marianum]. | silybum marianum l. (milk thistle) is native to the mediterranean basin and is now widespread throughout the world. it's sprout is used as a herbal medicine for the treatment of liver disease for centuries. the seeds of milk thistle contain silymarin, an isomeric mixture of flavonolignans [silybin, silychristin, and silydianin]. silymarin acts as a strong anti-hepatotoxic. | 2017 | 28216891 |
| synthesis, structure and antimicrobial properties of novel benzalkonium chloride analogues with pyridine rings. | quaternary ammonium compounds (qacs) are a group of compounds of great economic significance. they are widely used as emulsifiers, detergents, solubilizers and corrosion inhibitors in household and industrial products. due to their excellent antimicrobial activity qacs have also gained a special meaning as antimicrobials in hospitals, agriculture and the food industry. the main representatives of the microbiocidal qacs are the benzalkonium chlorides (bacs), which exhibit biocidal activity agains ... | 2017 | 28098790 |
| evaluation of wound healing, anti-microbial and antioxidant potential of pongamia pinnata in wistar rats. | to investigate wound healing, antimicrobial and antioxidant activity of leaf extract of pongamia pinnata. | 2017 | 28053891 |
| fermentation of sarshir (kaymak) by lactic acid bacteria: antibacterial activity, antioxidant properties, lipid and protein oxidation and fatty acid profile. | the antioxidant and antibacterial activity of fermented sarshir (traditional dairy food), with three probiotic lactobacillus plantarum strains (lp3, af1, and lu5) were investigated. the oxidative stability and lipid profile of non-fermented and fermented sarshir were compared, as well as radical scavenging activity, peroxide, anisidine, and carbonyl values (pv, anv, and cv, respectively). | 2017 | 28349539 |
| biofilm inhibition formation of clinical strains of pseudomonas aeruginosa mutans, photocatalytic activity of azo dye and gc-ms analysis of leaves of lagerstroemia speciosa. | the investigation was conducted to analyse the bioactive compounds from the leaf extracts of l. speciosa by gc-ms. the extracts were screened for antibacterial and antibiofilm activities against potential clinical strains. the bioactive compounds from the leaves of l. speciosa were extracted by soxhlet continuous extraction method and their chemical composition was analysed by gas chromatography-mass spectroscopy (gc-ms). the antibacterial activity was evaluated against clinical strain like stap ... | 2017 | 28319869 |
| the antibacterial activity of extracts of nine plant species with good activity against escherichia coli against five other bacteria and cytotoxicity of extracts. | the development of antibiotic resistant bacteria stems from a number of factors, including inappropriate use of antibiotics in human and animal health and their prolonged use as growth promoters at sub-clinical doses in poultry and livestock production. we were interested in investigating plants that could be useful in protecting humans or animals against diarrhoea. we decided to work on extracts of nine plant species with good activity against escherichia coli based on earlier work in the phyto ... | 2017 | 28241818 |
| kinneretia thg-sqi4 mediated biosynthesis of silver nanoparticles and its antimicrobial efficacy. | simple, facile, effective approach for the biosynthesis of silver nanoparticles using kinneretia species and its antimicrobial activity against human pathogens has been demonstrated in this study. kinneretia thg-sqi4 has been isolated from soil sample collected from shangqui, china. the synthesized nanoparticles were characterized by ultraviolet-visible spectrophotometry (uv-vis), field emission transmission electron microscopy (fe-tem), energy dispersive x-ray spectroscopy (edx), elemental mapp ... | 2017 | 28211298 |
| antibiogram of bacteria isolated from automated teller machines in hamadan, west iran. | aim: bacteria are ubiquitous in the environment. in keeping with the continued expansion of urbanization and the growing population, an increasing number of people use automated banking, i.e. automated teller machines (atms). the aim of this study was to investigate the bacterial contamination and its antibiotic sensitivity on computer keyboards located at atms in hamadan province, iran. method: out of 360 atms at four locations in hamadan, 96 were randomly selected for this study. the antibioti ... | 2017 | 28197394 |
| design, synthesis, and antibacterial activities of novel heterocyclic arylsulphonamide derivatives. | design, synthesis, and antibacterial activities of a series of arylsulphonamide derivatives as probable peptide deformylase (pdf) inhibitors have been discussed. compounds have been designed following lipinski's rule and after docking into the active site of pdf protein (pdb code: 1g2a) synthesized later on. furthermore, to assess their antibacterial activity, screening of the compound was done in vitro conditions against gram-positive and gram-negative bacterial strains. in silico, studies reve ... | 2017 | 28194576 |
| epidihydropinidine, the main piperidine alkaloid compound of norway spruce (picea abies) shows promising antibacterial and anti-candida activity. | this study reports for the first time promising antibacterial and antifungal effects of epidihydropinidine, the major piperidine alkaloid in the needles and bark of norway spruce, picea abies (l.) karsten. epidihydropinidine was growth inhibitory against all bacterial and fungal strains used in our investigation, showing the lowest mic value of 5.37μg/ml against pseudomonas aeruginosa, enterococcus faecalis, candida glabrata and c. albicans. epidihydropinidine was nearly three times more active ... | 2017 | 28163074 |
| synthesis and antibacterial evaluation of new n- and s-glycosides analogues with dinitrophenyl-substituted heterocyclic bases. | four n- and s-glycosides 13-16 having nucleobases 7-12 binding to sugar molecules from one side and to 3,5-dinitrophenyl moieties from another side were synthesized from 3,5-dinitrobenzoic acid 2. the synthetic intermediates, hydrazide 5 and thiosemicarbazide 6 regarded as important key compounds for the synthesis of nucleobases 7-12, each was obtained by two approaches. structures of synthesized compounds were determined spectroscopically. antibacterial activities for synthetic intermediates an ... | 2017 | 27761763 |
| biochemical and biological characterization of two brassicaceae after their commercial expiry date. | two brassicaceae (eruca sativa, brassica oleracea var. sabauda) were stored in air and under a modified atmosphere for several days after their expiry date and then analyzed. the polyphenol content and composition, as well as the antioxidant activity of the extracts, were assessed, compared to the fresh products. antimicrobial properties on tester strains (bacillus cereus, escherichia coli, staphylococcus aureus and pseudomonas aeruginosa) and in vitro anti-proliferative activity were evaluated. ... | 2017 | 27719918 |
| inactivation and changes in metabolic profile of selected foodborne bacteria by 460 nm led illumination. | the objective of this study was to investigate the effect of 460 nm light-emitting diode (led) on the inactivation of foodborne bacteria. additionally, the change in the endogenous metabolic profile of led illuminated cells was analyzed to understand the bacterial response to the led illumination. six different species of bacteria (bacillus cereus, listeria monocytogenes, staphylococcus aureus, escherichia coli o157:h7, pseudomonas aeruginosa and salmonella typhimurium) were illuminated with 460 ... | 2017 | 28040158 |
| cmc stabilized nano silver synthesis, characterization and its antibacterial and synergistic effect with broad spectrum antibiotics. | in the present study silver nanoparticles were synthesized by reduction of agno3 using aqueous cmc solution, which acts as both reducing and capping agent. the formation of agno3 nanoparticles was observed visually by color change and these nanoparticles were characterized through uv-vis spectroscopy, ftir, xrd, sem, eds and afm. the ftir peaks observed to be ranging from 3300 to 605cm(-1). the afm image clearly showed the surface morphology of well dispersed nanoparticles. sem image illustrates ... | 2017 | 28024537 |
| hptlc fingerprint profile, in vitro antioxidant and evaluation of antimicrobial compound produced from brevibacillus brevis-egs9 against multidrug resistant staphylococcus aureus. | in the present study, in vitro antimicrobial activity of brevibacillus brevis egs9 against multi drug resistant staphylococcus aureus (mdrsa) and to investigate the antimicrobial, antioxidant activity and hptlc finger print profile of brevibacillus brevis egs9. primary screening was done using by cross streak method against multi drug resistant staphylococcus aureus. the bioactive metabolites were extracted from brevibacillus brevis egs9 using ethyl acetate extraction. ethyl acetate extract show ... | 2017 | 27939872 |
| antibacterial, antioxidant and anti-proliferative properties and zinc content of five south portugal herbs. | crataegus monogyna l. (rosaceae) (cm), equisetum telmateia l. (equisataceae) (et), geranium purpureum vil. (geraniaceae) (gp), mentha suaveolens ehrh. (lamiaceae) (ms), and lavandula stoechas l. spp. luisieri (lamiaceae) (ls) are all medicinal. | 2017 | 27925492 |
| biosynthesis of silver nanoparticles by novosphingobium sp. thg-c3 and their antimicrobial potential. | the present study described biosynthesis of silver nanoparticles (agnps) using a bacterial strain novosphingobium sp. thg-c3, isolated from soil, and their application in antibacterial activity. the maximum absorbance values of the synthesized agnps was measured at 406 nm in ultraviolet-visible spectrophotometry and were mostly spherical in shape with particle size in range of 8-25 nm by field emission transmission electron microscopy analysis. x-ray diffraction pattern corresponding to planes ( ... | 2017 | 27145847 |
| microbiological isolates and antibiotic susceptibilities: a 10-year review of culture-proven endophthalmitis cases. | to review the microbiological spectrum and antibiotic sensitivities of the pathogens that cause culture-proven endophthalmitis and to understand the status and trends of antibiotic susceptibility at a public hospital over a 10-year period. | 2017 | 27347700 |
| tid: standalone software for mining putative drug targets from bacterial proteome. | tid is a standalone application, which relies on basic assumption that a protein must be essential for pathogens survival and non-homologous with host to qualify as putative target. with an input bacterial proteome, tid removes paralogous proteins, picks essential ones, and excludes proteins homologous with host organisms. the targets illustrate non-homology with at least 40 out of 84 gut microbes, considered safe for human. tid classifies proposed targets as known, novel and virulent. users can ... | 2017 | 27856224 |
| risk factors for post-traumatic endophthalmitis in patients with positive intraocular cultures. | to determine the risk factors for post-traumatic endophthalmitis in patients with positive intraocular culture. | 2017 | 28221562 |
| rhamnolipids from pseudomonas aeruginosa strain w10; as antibiofilm/antibiofouling products for metal protection. | industrial biofouling-problems associated with the accumulation of microorganisms from flowing water and fluids on processing surfaces can cause severe problems. a pseudomonas aeruginosa strain w10 was isolated from industrial setting and found to produce predominantly di-rhamnolipids (rha-rha-c10-c10) with a yield of around 10 g l(-1) and a critical micelle concentration (cmc) of 80 mg l(-1) . p. aeruginosa w10 rhamnolipids were able to disrupt up to 99% of 48 h pre-formed biofilms of the gram- ... | 2017 | 28156000 |
| biological therapeutics of pongamia pinnata coated zinc oxide nanoparticles against clinically important pathogenic bacteria, fungi and mcf-7 breast cancer cells. | the overuse of antimicrobics and drugs has led to the development of resistance in a number of pathogens and parasites, which leads to great concerns for human health and the environment. furthermore, breast cancer is the second most common cause of cancer death in women. mcf-7 is a widely used epithelial cancer cell line, derived from breast adenocarcinoma for in vitro breast cancer studies, since the cell line has retained several ideal characteristics particular to the mammary epithelium. in ... | 2017 | 28115262 |
| molecular cloning and characterization of antimicrobial peptides from skin of hylarana guentheri. | the cdnas encoding antimicrobial peptides (amps) in the skin of hylarana guentheri were identified, namely temporin (five peptides, termed temporin-gha-ghd and temporin-gua), brevinin-1 (one peptide, brevinin-1gub), and brevinin-2 (eight peptides, brevinin-2ghd-2ghj, and brevinin-2ghb). eleven of the 14 peptides have novel primary structures. synthesized temporin gha-ghd have broad-spectrum antimicrobial activities against gram-positive bacteria (staphylococcus aureus and bacillus subtilis), gra ... | 2017 | 28338958 |
| cationic net charge and counter ion type as antimicrobial activity determinant factors of short lipopeptides. | to get a better insight into the antimicrobial potency of short cationic lipopeptides, 35 new entities were synthesized using solid phase peptide strategy. all newly obtained lipopeptides were designed to be positively charged from +1 to +4. this was achieved by introducing basic amino acid - lysine - into the lipopeptide structure and had a hydrophobic fatty acid chain attached. lipopeptides were subjected to microbiological tests using reference strains of gram-negative bacteria: escherichia c ... | 2017 | 28203232 |
| microorganisms and heavy metals associated with atmospheric deposition in a congested urban environment of a developing country: sri lanka. | the presence of bacteria and heavy metals in atmospheric deposition were investigated in kandy, sri lanka, which is a typical city in the developing world with significant traffic congestion. atmospheric deposition samples were analyzed for al, cr, mn, fe, ni, cu, zn, cd and pb which are heavy metals common to urban environments. al and fe were found in high concentrations due to the presence of natural sources, but may also be re-suspended by vehicular traffic. relatively high concentrations of ... | 2017 | 28185730 |
| broad-spectrum of antimicrobial properties of commercial wines from different vitis vinifera l. varieties. | fifteen commercial wines produced from international and autochthonic varieties of vitis vinifera l. cultivation of different balkan winegrowing subregions were studied for their antimicrobial activity against six gram-positive (clostridium perfringens, bacillus subtilis, staphylococcus aureus, listeria inocua, sarcina lutea and micrococcus flavus) and six gram-negative (escherichia coli, pseudomonas aeruginosa, salmonella enteritidis, shigella sonnei, klebsiella pneumonia and proteus vulgaris) ... | 2017 | 27905092 |
| antimicrobial activity of biogenically produced spherical se-nanomaterials embedded in organic material against pseudomonas aeruginosa and staphylococcus aureus strains on hydroxyapatite-coated surfaces. | in an effort to prevent the formation of pathogenic biofilms on hydroxyapatite (ha)-based clinical devices and surfaces, we present a study evaluating the antimicrobial efficacy of spherical biogenic se-nanostructures embedded in organic material (bio se-nemo-s) produced by bacillus mycoides selte01 in comparison with two different chemical selenium nanoparticle (senp) classes. these nanomaterials have been studied as potential antimicrobials for eradication of established ha-grown biofilms, for ... | 2017 | 28233476 |
| chemical composition, antimicrobial, antioxidant and anthocyanin activities of mosses (cinclidotus fontinaloides (hedw.) p.beauv. and palustriella commutata (hedw.) ochyra) gathered from turkey. | cinclidotus fontinaloides (hedw.) p. beauv. and palustriella commutata (hedw.) ochyra were used in this study. the chemical composition of mosses in the ethanol and water extract was determined using gc-ms and ft-ir. antioxidant activities of moss extracts were tested by total phenol and abts methods. trolox equivalent value (teac) of mosses was calculated as 26 ± 0.32 and 10 ± 0.22 mg/g. the amounts of the flavonoid compounds were calculated as mg gallic acid. gallic acid equivalent value of mo ... | 2017 | 28067067 |
| species-independent attraction to biofilms through electrical signaling. | bacteria residing within biofilm communities can coordinate their behavior through cell-to-cell signaling. however, it remains unclear if these signals can also influence the behavior of distant cells that are not part of the community. using a microfluidic approach, we find that potassium ion channel-mediated electrical signaling generated by a bacillus subtilis biofilm can attract distant cells. integration of experiments and mathematical modeling indicates that extracellular potassium emitted ... | 2017 | 28086091 |
| transfer and expression of the rabbit defensin np-1 gene in lettuce (lactuca sativa). | lettuce (lactuca sativa l.) is an annual plant of the daisy family, asteraceae, with high food and medicinal value. however, the crop is susceptible to several viruses that are transmitted by aphids and is highly vulnerable to post-harvest diseases, as well as insect and mammal pests and fungal and bacterial diseases. here, the rabbit defensin gene np-1 was transferred into lettuce by agrobacterium-mediated transformation to obtain a broad-spectrum disease-resistant lettuce. transgenic lettuce p ... | 2017 | 28128415 |
| study of the dual effect of gamma irradiation and strontium substitution on bioactivity, cytotoxicity, and antimicrobial properties of 45s5 bioglass. | in this work, we studied simultaneous effect of gamma irradiation and sro substitution for na2 o on bioactivity, cytotoxicity and antimicrobial properties of 45s5 glass. gamma irradiation was mainly introduced in this work as an effective sterilizing technique, improvement of bulk properties and surface modification of glass. where, gamma irradiation is considered a modifier for glass network due to generation of defects resulted from this irradiation. furthermore, sro was introduced into the gl ... | 2017 | 28187505 |
| [purification of human goose-type lysozyme 2 (hlysg2) from human seminal plasma and analysis of its enzymatic properties]. | objective to purify human goose-type lysozyme 2 (hlysg2) from human seminal plasma by chromatography and analyze its enzymatic properties. methods the distribution of hlysg2 in semen was analyzed by western blot analysis. seminal plasma was subjected to the separation of target protein using cation-exchange chromatography, chitin affinity chromatography and size-exclusion chromatography. the purified product was identified by western blot analysis and mass spectrometry (ms).the purity was analyz ... | 2017 | 28274309 |
| antibacterial screening of rumex species native to the carpathian basin and bioactivity-guided isolation of compounds from rumex aquaticus. | plants belonging to the genus rumex (family polygonaceae) are used worldwide in traditional medicine for the treatment of various diseases caused by different microorganisms (e.g. bacteria-related dermatologic conditions, dysentery and enteritis). the present study focused on the antibacterial screening of rumex species native to the carpathian basin, and isolation of compounds from one of the most efficient species, rumex aquaticus. the antibacterial effects of n-hexane, chloroform and aqueous ... | 2017 | 28300698 |
| phytochemical investigation of aloe pulcherrima roots and evaluation for its antibacterial and antiplasmodial activities. | medicinal plants with documented traditional uses remain an important source for the treatment of a wide range of ailments. evidence shows that majority of the ethiopian population are still dependent on traditional medicine. aloe pulcherrima gilbert & sebsebe is one of the endemic aloe species traditionally used for the treatment of malaria and wound healing in central, southern and northern part of ethiopia. the aim of the current study was, therefore, to isolate active compounds from roots of ... | 2017 | 28333961 |
| new mechanistic insights into the motile-to-sessile switch in various bacteria with particular emphasis on bacillus subtilis and pseudomonas aeruginosa: a review. | a biofilm is a complex assemblage of microbial communities adhered to a biotic or an abiotic surface which is embedded within a self-produced matrix of extracellular polymeric substances. many transcriptional regulators play a role in triggering a motile-sessile switch and in consequently producing the biofilm matrix. this review is aimed at highlighting the role of two nucleotide signaling molecules (c-di-gmp and c-di-amp), toxin antitoxin modules and a novel transcriptional regulator bola in b ... | 2017 | 28347177 |
| facile and green synthesis of phytochemicals capped platinum nanoparticles and in vitro their superior antibacterial activity. | the increase in the severe infectious diseases and resistance of the majority of the bacterial pathogens to the available drug is a serious problem now a day. in order to overcome this problem it is necessary to develop new therapeutic agents which are non-toxic and more effective to inhibit these microbial pathogens. for this purpose the plant extract of highly active medicinal plant, taraxacum laevigatum was used for the synthesis of platinum nanoparticles (ptnps) to enhance its bio-activities ... | 2017 | 28011434 |
| synthesis and characterization of nanosilver-silicone hydrogel composites for inhibition of bacteria growth. | nanosilver-silicone hydrogel (nagsih) composites for contact lenses were synthesized to asses the antimicrobial effects. | 2017 | 27693238 |
| a new α-pyrone from the mangrove endophytic fungus phomopsis sp. hny29-2b. | a new α-pyrone derivative, phomopyrone a (1), together with two known compounds (2-3), was isolated from the culture of the mangrove endophytic fungus phomopsis sp. hny29-2b. their structures were determined by detailed analysis of spectroscopic data. the configuration of 1 was further confirmed by x-ray diffraction. all isolated compounds were evaluated for antibacterial and antioxidative activities. compound 2 exhibited antibacterial activities with minimal inhibition concentration (mic) value ... | 2017 | 27687677 |
| design, synthesis, and biological evaluation of chrysin derivatives as potential fabh inhibitors. | new series of chrysin derivatives (4a-4t) were designed and synthesized by introducing different substituted piperazines at c-7 position. their inhibitory effects on fabh were evaluated using two gram-negative bacterial strains, escherichia coli and pseudomonas aeruginosa, and two gram-positive bacterial strains, bacillus subtilis and staphylococcus aureus. to our delight, most of these compounds exhibited a dramatic increase in inhibitory potency, compared with the control positive drugs. among ... | 2017 | 27860280 |
| purification, characterization and functional analysis of the immune molecule lectin from the haemolymph of blue swimmer crab portunus pelagicus and their antibiofilm properties. | the present study reveals purification and characterization of immune molecule lectin from the haemolymph of blue swimmer crab portunus pelagicus (pp-lec). the pp-lec was purified by affinity chromatography with mannose coupled sepharose cl-4b column and it exhibits single band with a molecular weight of 155 kda in sds-page. the surface morphology of purified pp-lec displays the homogeneous nature of protein. a distinct peak with a retention time of 3.3 min was appeared in high performance liqui ... | 2017 | 28110033 |
| microbiology of cooked and dried edible mediterranean field crickets (gryllus bimaculatus) and superworms (zophobas atratus) submitted to four different heating treatments. | to increase the shelf life of edible insects, modern techniques (e.g. freeze-drying) add to the traditional methods (degutting, boiling, sun-drying or roasting). however, microorganisms become inactivated rather than being killed, and when rehydrated, many return to vegetative stadia. crickets (gryllus bimaculatus) and superworms (zophobas atratus) were submitted to four different drying techniques (t1 = 10' cooking, 24 h drying at 60℃; t2 = 10' cooking, 24 h drying at 80℃; t3 = 30' cooking, 12 ... | 2017 | 27235993 |
| association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly. | the pathway leading from amyloid-β deposition to cognitive impairment is believed to be a cornerstone of the pathogenesis of alzheimer's disease (ad). however, what drives amyloid buildup in sporadic nongenetic cases of ad is still unknown. ad brains feature an inflammatory reaction around amyloid plaques, and a specific subset of the gut microbiota (gmb) may promote brain inflammation. we investigated the possible role of the gmb in ad pathogenesis by studying the association of brain amyloidos ... | 2017 | 27776263 |
| antibiotic capture by bacterial lipocalins uncovers an extracellular mechanism of intrinsic antibiotic resistance. | the potential for microbes to overcome antibiotics of different classes before they reach bacterial cells is largely unexplored. here we show that a soluble bacterial lipocalin produced by burkholderia cenocepacia upon exposure to sublethal antibiotic concentrations increases resistance to diverse antibiotics in vitro and in vivo these phenotypes were recapitulated by heterologous expression in b. cenocepacia of lipocalin genes from pseudomonas aeruginosa, mycobacterium tuberculosis, and methici ... | 2017 | 28292982 |
| a broad host range tailocin from burkholderia cenocepacia. | the burkholderia cepacia complex (bcc) consists of 20 closely related gram-negative bacterial species that are significant pathogens for persons with cystic fibrosis (cf). some bcc strains are highly transmissible and resistant to multiple antibiotics, making infection difficult to treat. a tailocin (phage-tail-like bacteriocin), designated bcetmilo, with broad host range against members of the bcc was identified in burkholderia cenocepacia strain bc0425. sixty-eight percent of bcc representing ... | 2017 | 28258146 |
| cheating fosters species co-existence in well-mixed bacterial communities. | explaining the enormous biodiversity observed in bacterial communities is challenging because ecological theory predicts that competition between species occupying the same niche should lead to the exclusion of less competitive community members. competitive exclusion should be particularly strong when species compete for a single limiting resource or live in unstructured habitats that offer no refuge for weaker competitors. here, we describe the 'cheating effect', a form of intra-specific compe ... | 2017 | 28060362 |
| bacterial proteases and haemostasis dysregulation in the cf lung. | pathogenic bacteria which chronically colonise the cystic fibrosis (cf) lung produce a number of virulence determinants, including distinct proteolytic activities. the potential role bacterial proteases play on haemostatic dysregulation within the cf lung is, however, poorly defined, despite haemoptysis being a common complication in cf. | 2017 | 27839953 |
| biofilm colonization in chronic treatment refractory infections presenting with discharging sinuses: a study in a tertiary care hospital of eastern india. | treatment refractory chronic recurrent infections mean those chronic infections which recur by same causal agents with similar drug responsiveness after apparent relief following full course of recommended antimicrobial management. | 2017 | 28367029 |
| cystic fibrosis in austria. | registry data for patients with cystic fibrosis (cf) are increasingly used to evaluate the natural history, for benchmarking of therapy and in order to identify eligible patients for clinical studies. so far, no data on frequency and clinical status of cf patients have been available for austria on a national level. we collected data of cf patients treated 2014 in austrian cf outpatient clinics by means of a european cf registry and on an individual search basis. a total of 773 cf patients with ... | 2017 | 28236043 |
| the risk of microbial contamination in multiple-dose preservative-free ophthalmic preparations. | multiple-dose ophthalmic preparations that do not contain preservatives carry high risks of microbial contamination. however, there are various types of hospital preparations, with different physicochemical properties. in the present study, we evaluated the association between physicochemical properties and microbial contamination in ophthalmic preparations. the investigated hospital preparations included ophthalmic preparations of physiological saline, 0.2% fluconazole, 0.5% vancomycin hydrochl ... | 2017 | 28154258 |
| the changing prevalence of pulmonary infection in adults with cystic fibrosis: a longitudinal analysis. | increased patient longevity and aggressive antibiotic treatment are thought to impact on the microbial composition of the airways of adults with cystic fibrosis (cf). in this study, we sought to determine if a temporal change in the airway microbiology of adults with cf has occurred over time. | 2017 | 27515017 |
| peptide modification results in the formation of a dimer with a 60-fold enhanced antimicrobial activity. | cationic antimicrobial peptides (camps) occur naturally in numerous organisms and are considered as a class of antibiotics with promising potential against multi-resistant bacteria. herein, we report a strategy that can lead to the discovery of novel small camps with greatly enhanced antimicrobial activity and retained antibiofilm potential. we geared our efforts towards i) the n-terminal cysteine functionalization of a previously reported small synthetic cationic peptide (peptide 1037, krfrirvr ... | 2017 | 28296935 |
| comparative study on the in vitro effects of pseudomonas aeruginosa and seaweed alginates on human gut microbiota. | alginates pertain to organic polysaccharides that have been extensively used in food- and medicine-related industries. the present study obtained alginates from an alginate overproducing pseudomonas aeruginosa pao1 mutant by screening transposon mutagenesis libraries. the interaction between bacterial and seaweed alginates and gut microbiota were further studied by using an in vitro batch fermentation system. thin-layer chromatography (tlc) analysis indicated that both bacterial and seaweed algi ... | 2017 | 28170428 |
| role of vfr in the regulation of antifungal compound production by pseudomonas fluorescens fd6. | pseudomonas fluorescens fd6 has been shown to possess many beneficial traits involved in the biocontrol of fungal plant pathogens, such as botrytis cinerea and monilinia fructicola. vfr (virulence factor regulator) a highly conserved global regulator of gram-negative bacteria, such as the human pathogen pseudomonas aeruginosa, is required for the expression of many important virulence traits. the role of vfr in the regulation of biocontrol traits, such as the production of antibiotics to control ... | 2017 | 27296968 |
| host immune recognition of the epidemic cystic fibrosis pathogen burkholderia dolosa. | burkholderia dolosa caused an outbreak in the cystic fibrosis (cf) clinic at boston children's hospital from 1998 to 2005 and led to the infection of over 40 patients, many of whom died due to complications from infection by this organism. to assess whether b. dolosa significantly contributes to disease or is recognized by the host immune response, mice were infected with a sequenced outbreak b. dolosa strain, au0158, and responses compared to the well-studied cf pathogen, pseudomonas aeruginosa ... | 2017 | 28348057 |
| microbial rhamnolipid production: a critical re-evaluation of published data and suggested future publication criteria. | high production cost and potential pathogenicity of pseudomonas aeruginosa, commonly used for rhamnolipid synthesis, have led to extensive research for safer producing strains and cost-effective production methods. this has resulted in numerous research publications claiming new non-pathogenic producing strains and novel production techniques many of which are unfortunately without proper characterisation of product and/or producing strain/s. genes responsible for rhamnolipid production have onl ... | 2017 | 28386631 |
| biosynthesis of di-rhamnolipids and variations of congeners composition in genetically-engineered escherichia coli. | to engineer escherichia coli for the heterologous production of di-rhamnolipids, which are important biosurfactants but mainly produced by opportunistic pathogen pseudomonas aeruginosa. | 2017 | 28374071 |
| antimicrobial percutaneous nephrostomy catheters for the prevention of renal infections: in vitro studies. | purpose - percutaneous nephrostomy (pcn) catheters are the primary method for draining ureters obstructed by malignancy and preventing a decline of the renal function. however, pcn-related infections such as pyelonephritis and urosepsis remain a significant concern. currently no antimicrobial pcns are available for preventing infectious complications. vascular catheters impregnated with minocycline/rifampin (m/r) and m/r with chlorhexidine coating (m/r+chd) have previously demonstrated antimicro ... | 2017 | 28320713 |
| biological activities of rosmarinus officinalis l. (rosemary) extract as analyzed in microorganisms and cells. | r. officinalis l. is an aromatic plant commonly used as condiment and for medicinal purposes. biological activities of its extract were evaluated in this study, as antimicrobial effect on mono- and polymicrobial biofilms, cytotoxicity, anti-inflammatory capacity, and genotoxicity. monomicrobial biofilms of candida albicans, staphylococcus aureus, enterococcus faecalis, streptococcus mutans and pseudomonas aeruginosa and polymicrobial biofilms composed of c. albicans with each bacterium were form ... | 2017 | 28093936 |
| bad to the bone: on in vitro and ex vivo microbial biofilm ability to directly destroy colonized bone surfaces without participation of host immunity or osteoclastogenesis. | bone infections are a significant public health burden associated with morbidity and mortality in patients. microbial biofilm pathogens are the causative agents in chronic osteomyelitis. research on the pathogenesis of osteomyelitis has focused on indirect bone destruction by host immune cells and cytokines secondary to microbial insult. direct bone resorption by biofilm pathogens has not yet been seriously considered. in this study, common osteomyelitis pathogens (staphylococcus aureus, pseudom ... | 2017 | 28076372 |
| visible light enhances the antimicrobial effect of some essential oils. | the photodisinfection is a topical, broad spectrum antimicrobial technology, targeting bacteria, virus, fungi, and protozoa effective for single cells as for biofilms. natural molecules have been studied less than synthetic agents in the process but they are currently receiving great interest. therefore, the aim of this study is to evaluate for the first time if non-coherent blue and red light enhances the antimicrobial activity of some essential oils when standard strains for antibiotic or fung ... | 2017 | 27965057 |
| bacterial and fungal biofilm formation on anodized titanium alloys with fluorine. | orthopaedic device-related infections are closely linked to biofilm formation on the surfaces of these devices. several modified titanium (ti-6al-4v) surfaces doped with fluorine were studied in order to evaluate the influence of these modifications on biofilm formation by gram-positive and gram-negative bacteria as well as a yeast. the biofilm studies were performed according to the standard test method approved by astm (designation: e2196-12) using the rotating disk reactor. four types of ti-6 ... | 2017 | 27896598 |
| polymicrobial ventilator-associated pneumonia: fighting in vitro candida albicans-pseudomonas aeruginosa biofilms with antifungal-antibacterial combination therapy. | the polymicrobial nature of ventilator-associated pneumonia (vap) is now evident, with mixed bacterial-fungal biofilms colonizing the vap endotracheal tube (ett) surface. the microbial interplay within this infection may contribute for enhanced pathogenesis and exert impact towards antimicrobial therapy. consequently, the high mortality/morbidity rates associated to vap and the worldwide increase in antibiotic resistance has promoted the search for novel therapeutic strategies to fight vap polym ... | 2017 | 28114348 |
| ex vivo rabbit and human corneas as models for bacterial and fungal keratitis. | in the study of microbial keratitis, in vivo animal models often require a large number of animals, and in vitro monolayer cell culture does not maintain the three-dimensional structure of the tissues or cell-to-cell communication of in vivo models. here, we propose reproducible ex vivo models of single- and dual-infection keratitis as an alternative to in vivo and in vitro models. | 2017 | 27844206 |
| production of potent antimicrobial compounds from streptomyces cyaneofuscatus associated with fresh water sediment. | the genus streptomyces under phylum actinobacteria has been recognized as a prolific source for the production of bioactive secondary metabolites. an actinobacterial strain designated as dst103 isolated from a wetland fresh water sediment of tamdil lake, mizoram, northeast, india was identified as streptomyces cyaneofuscatus (ky287599) using 16srrna gene sequencing which shares 99.87% sequence similarity with streptomyces cyaneofuscatus nrrl b-2570 (t) . the strain showed broad spectrum antimicr ... | 2017 | 28179900 |
| [pathogens of infections in the induction period of childhood acute lymphoblastic leukemia and drug resistance of isolated strains]. | to investigate the infections occurring in the induction period of childhood acute lymphoblastic leukemia (all), the pathogens of the infections, and drug resistance of isolated strains. | 2017 | 28202116 |
| pseudomonas aeruginosa produces aspirin insensitive eicosanoids and contributes to the eicosanoid profile of polymicrobial biofilms with candida albicans. | the interaction of clinically relevant microorganisms is the focus of various studies, e.g. the interaction between the pathogenic yeast, candida albicans, and the bacterium, pseudomonas aeruginosa. during infection both release arachidonic acid, which they can transform into eicosanoids. this study evaluated the production of prostaglandin e2, prostaglandin f2α and 15-hydroxyeicosatetraenoic acid by biofilms of p. aeruginosa and c. albicans. the influence of co-incubation, acetylsalicylic acid ... | 2017 | 28237086 |
| desferrioxamine and desferrioxamine-caffeine as carriers of aluminum and gallium to microbes via the trojan horse effect. | iron acquisition by bacteria and fungi involves in several cases the promiscuous usage of siderophores. thus, antibiotic resistance from these microorganisms can be circumvented through a strategy of loading toxic metals into siderophores (trojan horse effect). desferrioxamine (dfo) and its cell-permeant derivative desferrioxamine-caffeine (dfcaf) were complexed with aluminum or gallium for this purpose. the complexes me(dfo) and me(dfcaf) (me=al(3+) and ga(3+)) were synthesized and characterize ... | 2017 | 28347458 |
| colony fingerprint for discrimination of microbial species based on lensless imaging of microcolonies. | detection and identification of microbial species are crucial in a wide range of industries, including production of beverages, foods, cosmetics, and pharmaceuticals. traditionally, colony formation and its morphological analysis (e.g., size, shape, and color) with a naked eye have been employed for this purpose. however, such a conventional method is time consuming, labor intensive, and not very reproducible. to overcome these problems, we propose a novel method that detects microcolonies (diam ... | 2017 | 28369067 |
| holothurians antifungal and antibacterial activity to human pathogens in the persian gulf. | pharmaceutical industries now accept that oceans contain a vast array of organisms with unique biological properties. as investigation of antimicrobial activity, three species of holothuria sea cucumbers (holothuria scabra, holothuria parva and holothuria leucospilota) from the persian gulf, iran, were obtained, their different organs: gonads (g), body wall (bw), intestine tract (it), respiratory tree (rt) were isolated and extracted with organic solvents: ethyl acetate and methanol. antifungal ... | 2017 | 27641487 |
| human salivary protein histatin 5 has potent bactericidal activity against eskape pathogens. | eskape (enterococcus faecium, staphylococcus aureus, klebsiella pneumoniae, acinetobacter baumanni, pseudomonas aeruginosa, and enterobacter species) pathogens have characteristic multiple-drug resistance and cause an increasing number of nosocomial infections worldwide. peptide-based therapeutics to treat eskape infections might be an alternative to conventional antibiotics. histatin 5 (hst 5) is a salivary cationic histidine-rich peptide produced only in humans and higher primates. it has high ... | 2017 | 28261570 |
| rapid and low-cost biosensor for the detection of staphylococcus aureus. | staphylococcus aureus (s. aureus) is one of the most common etiological agents in hospital-acquired infections and food-borne illness. s. aureus toxins and virulence proteases often circulate in host blood vessels leading to life-threatening diseases. standard identification approaches include bacterial culturing method, which takes several days. other nucleic acid-based methods were expensive and required trained personnel. to surmount these limitations, a paper-based biosensor was developed. t ... | 2017 | 27914366 |
| structural investigation on wlarg from campylobacter jejuni: a sugar aminotransferase. | campylobacter jejuni is a gram-negative bacterium that represents a leading cause of human gastroenteritis worldwide. of particular concern is the link between c. jejuni infections and the subsequent development of guillain-barré syndrome, an acquired autoimmune disorder leading to paralysis. all gram-negative bacteria contain complex glycoconjugates anchored to their outer membranes, but in most strains of c. jejuni, this lipoglycan lacks the o-antigen repeating units. recent mass spectrometry ... | 2017 | 28028852 |
| bacterial and fungal biofilm formation on contact lenses and their susceptibility to lens care solutions. | microbial biofilm formation on contact lenses and lens storage cases may be a risk factor for contact lens-associated corneal infections. various types of contact lens care solutions are used to reduce microbial growths on lenses. | 2017 | 28303823 |