Publications

[lyme disease: a new infectious disease].		1983	6656464
neurologic abnormalities of lyme disease: successful treatment with high-dose intravenous penicillin.	twelve patients were treated with high-dose intravenous penicillin for neurologic abnormalities of lyme disease. headache, stiff neck, and radicular pain usually began to subside by the second day of therapy and were often gone by 7 to 10 days. five of the 12 patients continued to have intermittent mild headache for several more weeks, but no patient relapsed after therapy was stopped. compared to 15 previous patients treated with prednisone alone, the duration of meningitic syndrome was signifi ...	1983	6316826
lymphocytic meningoradiculitis in the united states.	lymphocytic meningoradiculitis (bannwarth's syndrome) is a radicular neuralgia associated with a chronic lymphocytic pleocytosis in cerebrospinal fluid and frequently with unilateral or bilateral peripheral facial weakness. most reported cases have occurred during the summer among adults living in central europe. lymphocytic meningoradiculitis has occurred in the united states in a few patients with lyme disease and erythema chronicum migrans. however, it may occur independently. we describe a w ...	1983	6685240
lyme disease.	lyme disease is a recently described disease of unknown cause that may involve the skin, joints, heart, or nervous system with characteristic symptoms. the disease follows a bite from an ixodes tick. symptoms are generally self-limited and despite the varied and sometimes protracted manifestations, the outcome of the disease is favorable. the epidemiologic, clinical, and laboratory features and treatment of lyme disease are reviewed.	1983	6353917
[lyme disease. a new or newly recognized clinical entity].		1983	6415420
lyme disease in northern california.	lyme disease is a recently described clinical entity with cutaneous, neurologic, articular and cardiac manifestations. since the original description of the disease in 1977, more than 500 cases have been reported. although the vast majority of patients have been from the area near lyme, connecticut, we have seen four patients from northern california with various aspects of lyme disease. this diagnosis should be considered in patients who have traveled to tick regions and who have a distinctive ...	1983	6636745
[erythema migrans disease. a contribution to its clinical features and relation to lyme disease].	a largely prospective study averaging 33 months was undertaken in 30 patients with and one without (chronic) erythema migrans. in one case erythema migrans disappeared spontaneously, in the 29 others it persisted up to six months, but quickly responded to antibiotic treatment. measured from the tick bite in 9 patients or from onset of the erythema migrans, arthritis and arthralgia appeared in ten patients on average 6.5 months (0.7-36), and persisted for eight months (0.2-42). in seven of these ...	1983	6872871
spirochaetal aetiology for lyme disease.		1983	6135024
the early clinical manifestations of lyme disease.	lyme disease, caused by a tick-transmitted spirochete, typically begins with a unique skin lesion, erythema chronicum migrans. of 314 patients with this skin lesion, almost half developed multiple annular secondary lesions; some patients had evanescent red blotches or circles, malar or urticarial rash, conjunctivitis, periorbital edema, or diffuse erythema. skin manifestations were often accompanied by malaise and fatigue, headache, fever and chills, generalized achiness, and regional lymphadeno ...	1983	6859726
ticks and lyme disease in the united states.		1983	6859709
treatment of the early manifestations of lyme disease.	during 1980 and 1981, we compared antibiotic regimens in 108 adult patients with early lyme disease. erythema chronicum migrans and its associated symptoms resolved faster in penicillin- or tetracycline-treated patients than in those given erythromycin (mean duration, 5.4 and 5.7 versus 9.2 days, f = 3.38, p less than 0.05). none of 39 patients given tetracycline developed major late complications (meningoencephalitis, myocarditis, or recurrent attacks of arthritis) compared with 3 of 40 penicil ...	1983	6407378
was it lyme disease?		1983	6880371
lyme disease in north carolina.	we report two cases of lyme disease in north carolina, further expanding the distribution of known sporadic cases of this predominantly northeastern problem in southern states. physicians in areas where lyme disease has traditionally not been recognized should be alerted to its characteristic rash (erythema chronicum migrans), tick vector (ixodes species), possible severe manifestations (neurologic, arthritic, and cardiac), and response to appropriate antibiotic therapy (penicillin or tetracycli ...	1983	6857306
lyme disease: a new entity.		1983	6573608
simultaneous occurrence of babesiosis and lyme disease.		1983	6682178
lyme disease is a spirochetosis. a review of the disease and evidence for its cause.	fourteen patients with lyme disease showed typical clinical features of erythema chronicum migrans. eighteen biopsy specimens in all were obtained from the cutaneous lesions of these patients. the predominant histologic finding was a superficial and deep perivascular and interstitial infiltrate composed mostly of lymphocytes, or lymphocytes and either plasma cells and eosinophils or both. the plasma cells were found most frequently in biopsy specimens taken from the peripheries of the lesions, w ...	1983	6410931
lyme disease--success for academia and the community.		1983	6828125
spirochetes isolated from the blood of two patients with lyme disease.	we isolated spirochetes from the blood of 2 of 36 patients in long island and westchester county, new york, who had signs and symptoms suggestive of lyme disease. the spirochetes were morphologically similar and serologically identical to organisms recently found to infect lxodes dammini ticks, which are endemic to the area and have been epidemiologically implicated as vectors of lyme disease. in both patients, there was a rise in specific antispirochetal antibodies in paired specimens of serum. ...	1983	6828119
the spirochetal etiology of lyme disease.	we recovered a newly recognized spirochete from the blood, skin lesions (erythema chronicum migrans [ecm]), or cerebrospinal fluid of 3 of 56 patients with lyme disease and from 21 of 110 nymphal or adult lxodes dammini ticks in connecticut. these isolates and the original one from l. dammini appeared to have the same morphologic and immunologic features. in patients, specific igm antibody titers usually reached a peak between the third and sixth week after the onset of disease; specific igg ant ...	1983	6828118
antibodies of patients with lyme disease to components of the ixodes dammini spirochete.	lyme disease is an inflammatory disorder of skin, joints, nervous system, and heart. the disease is associated with a preceding tick bite and is ameliorated by penicillin treatment. a spirochete (ids) isolated from ixodes dammini ticks has been implicated as the etiologic agent of lyme disease. we examined the antibody responses of lyme disease patients to ids lysate components in order to further understand the pathogenesis of this disease. the components were separated by sodium dodecyl sulfat ...	1983	6348092
natural distribution of the ixodes dammini spirochete.	spirochetes believed to be the cause of lyme disease were isolated from white-footed mice and white-tailed deer, the preferred natural hosts of ixodes dammini, the tick vector. evidence suggests that deer act as a reservoir of the disease and provide an overwintering mechanism for both spirochetes and adult ticks. some tick larvae may acquire the spirochete by transovarial passage and the nymphal stage may transmit the disease to humans.	1983	6836274
[chronic erythema migrans and tick-transmitted meningopolyneuritis (garin-bujadoux-bannwarth): borrelia infections?].	antibodies against borrelia duttoni using indirect immunofluorescence could be demonstrated in 6 patients with erythema chronicum migrans and in 8 persons with tick-borne meningopolyneuritis. significant increases of igg and igm antibody titres in the course of the disease and igg antibodies in the csf indicate recent contact with borrelia duttoni or a closely related agent. demonstration by fluorescence serology of spirochaetaceae in ixodes ricinus in two sites of infection equally indicate suc ...	1983	6839977
bacteriophage in the ixodes dammini spirochete, etiological agent of lyme disease.	a bacteriophage with a b-3 morphology was detected by electron microscopy in a spirochete isolated from the tick ixodes dammini. it has a 40- to 50-nm elongated head and a tail 50 to 70 nm in length. it appears devoid of collars or kite-tail structure. the spirochete has been identified as the causative agent of lyme disease.	1983	6853449
spirochetes in ixodes dammini and mammals from connecticut.	spirochetes were observed in the midguts of 35% of 147 motile ixodes dammini from three locations in lyme and east haddam, connecticut. positive ticks were removed from eastern chipmunks (tamias striatus), raccoons (procyon lotor), white-footed mice (peromyscus leucopus), and a red squirrel (tamiasciurus hudsonicus). spirochetes were isolated in fortified kelly's medium from nine questing or partially engorged i. dammini adults and nymphs and from the bloods of a raccoon and a white-footed mouse ...	1983	6881431
the spirochete in erythema chronicum migrans. demonstration by light and electron microscopy.	a lesion of erythema chronicum migrans was examined by light and electron microscopy. spirochetes were identified by light microscopy with steiner silver stain. electron microscopy was performed on deparaffinized tissue of the biopsy specimen and a spirochete was identified in the tissue. this treponema-like spirochete has morphological characteristics similar to those described previously for spirochetes obtained from ticks in areas endemic for lyme disease.	1983	6881479
[the spirochetal etiology of erythema chronicum migrans and garin-bujadoux-bannwarth meningo-polyneuritis].	erythema chronicum migrans and tick-born meningo-polyneuritis garin-bujadoux-bannwarth are caused by a spirochete transmitted by ixodes ricinus. the same is true of lyme disease, the erythema chronicum migrans infection of north america transmitted by ticks of the same genus. in europe demonstration of igg and igm antibodies against borrelia duttoni during the course of infection and by immunofluorescence staining of spirochetes in ticks at sites of infection indicate this etiology. in the usa a ...	1983	6884950
[the spirochetal etiology of erythema chronicum migrans and of meningo-polyneuritis garin-bujadoux-bannwarth].	erythema chronicum migrans and tick-borne meningo-polyneuritis garin-bujadoux-bannwarth are caused by a spirochete transmitted by ixodes ricinus. the same is true for lyme disease, which is the erythema chronicum migrans infection of north-america transmitted by ticks of the same genus. in europe, this etiology is indicated by demonstration of igg and igm antibodies against borrelia duttoni during the course of infection and by immunofluorescence staining of spirochetes in ticks at sites of infe ...	1983	6659638
"endotoxicity" of the lyme disease spirochete.		1983	6668073
antibodies to lyme-disease spirochaete in european lymphocytic meningoradiculitis (bannwarth's syndrome)		1983	6136679
lyme disease spirochetes and ixodid tick spirochetes share a common surface antigenic determinant defined by a monoclonal antibody.	ixodid tick-associated spirochetes have been implicated as the etiological agents of lyme disease. we raised a murine monoclonal antibody (h5332) against a spirochete, strain b31, isolated from ixodes dammini ticks. in indirect immunofluorescence assays and western blot analyses, h5332 reacted with whole cells or isolated components of not only strain b31 but also spirochetes isolated from ixodes ricinus ticks, a field mouse, a raccoon, and patients with lyme disease. in contrast, h5332 did not ...	1983	6192088
demyelinating neuropathy accompanying lyme disease.		1982	6890169
lyme disease.		1982	6815444
lyme disease--"what's new in old lyme?".		1982	7119538
lyme disease in new jersey: a cluster of 4 cases and 13 sporadic cases.		1982	6956739
lyme disease first observed to be aseptic meningitis.		1982	7081166
lyme disease and erythema chronicum migrans in minnesota.		1982	7078540
lyme disease challenges australian clinicians: the implications of australia's first reported case of lyme arthritis.		1982	7132842
lyme disease-a tick-borne spirochetosis?	a treponema-like spirochete was detected in and isolated from adult ixodes dammini, the incriminated tick vector of lyme disease. causally related to the spirochetes may be long-lasting cutaneous lesions that appeared on new zealand white rabbits 10 to 12 weeks after infected ticks fed on them. samples of serum from patients with lyme disease were shown by indirect immunofluorescence to contain antibodies to this agent. it is suggested that the newly discovered spirochete is involved in the etio ...	1982	7043737
lyme disease: additional evidence of widespread distribution. recognition of a tick-borne dermatitis-encephalitis-arthritis syndrome in an area of known ixodes tick distribution.	lyme disease is a process of unknown etiology that has been linked to bites of ticks of the ixodes ricinus complex. central minnesota is an area of known ixodes dammini distribution. this case represents the first recognition of lyme disease from this area. this case presented as a fluctuating meningoencephalitis with superimposed cranial neuropathy. the characteristic skin lesion, erythema chronicum migrans, was recognized by history, and oligoarticular arthritis subsequently developed. physici ...	1982	7072749
lyme disease.		1982	7081002
lyme disease: spirochetes up to old ticks?		1982	7097930
spirochete isolated in tick vectors of lyme disease.		1982	6807821
occurrence of erythema chronicum migrans and lyme disease among children in two noncontiguous connecticut counties.	in may-november 1977 erythema chronicum migrans of lyme arthritis occurred in at least 12 children in new london county, connecticut, east of the original 3-town epidemic focus. the attack rate (0.15 cases per 1,000 persons under 18) was considerably lower than within the focus itself but similar to the rate in towns west of the focus. no cases were identified in litchfield county in northwest connecticut. observed rates of lyme disease varied markedly within connecticut in 1977.	1981	7326064
lyme disease--united states, 1980.		1981	6793824
a case of "lyme disease" acquired in new jersey.		1981	6942167
symptomatic high grade heart block in lyme disease.	we describe an unusual and remediable form of heart block which developed in the course of lyme disease. the diagnosis of lyme disease requires a careful clinical history pertaining to epidemiologic geography or a history of erythema chronicum migrans. in this case, a highly selective cardiac abnormality responded promptly to systemic steroids.	1981	7460660
treatment of lyme disease.		1981	7447210
[erythema chronicum migrans with arthritis (author's transl)].	in a 46-year-old woman arthritis developed in several large joints eight weeks after the onset of erythema chronicum migrans. the joints of the leg were swollen and painful. in addition there was painful involvement bilaterally of knee, hip and elbow joints. circulating immune complexes were demonstrated in serum and the erythrocyte sedimentation rate was moderately increased. all other laboratory and radiological tests were within normal limits. on symptomatic treatment the arthritis regressed ...	1980	7439072
lyme disease: a new tick-transmitted illness now recognized in delaware.		1980	7202773
lyme disease.		1980	7423274
lyme carditis: cardiac abnormalities of lyme disease.	we studied 20 patients, mostly young adult men, with cardiac involvement of lyme disease. the commonest abnormality (18 patients) was fluctuating degrees of atrioventricular block; eight of them developed complete heart block. thirteen patients had evidence of more diffuse cardiac involvement: electrocardiographic changes compatible with acute myopericarditis (11 patients), radionuclide evidence of mild left ventricular dysfunction (five of 12 patients tested), or frank cardiomegaly (one patient ...	1980	6967274
antibiotic therapy in lyme disease.	we studied antibiotic efficacy in 113 patients with erythema chronicum migrans, the first manifestation of lyme disease. erythema chronicum migrans and its associated symptoms resolved faster in patients given penicillin or tetracycline (median duration, 4 and 2 days, respectively) than in untreated patients (10 days; p less than 0.001 and p = 0.005, respectively). erythromycin had no significant effect. although the frequency of subsequent neurologic and cardiac abnormalities was similar in all ...	1980	6967272
neurologic abnormalities of lyme disease.		1979	449663
cases of lyme disease in the united states: locations correlated with distribution of ixodes dammini.	lyme disease, defined by erythema chronicum migrans and sometimes followed by neurologic, cardiac, or joint involvement, is known to have affected 512 patients in the united states. the disease seems to occur in three distinct foci: along the northeastern coast, in wisconsin, and in california and oregon, a distribution that correlates closely with that of ixodes dammini in the first two areas and with ixodes pacificus in the last. the implicated tick, saved by six patients in the northeast, was ...	1979	496106
human exposure to tickborne relapsing fever spirochete borrelia miyamotoi, the netherlands.		0	24963562
seasonal prevalence of lyme disease spirochetes in a heterothermic mammal, the edible dormouse (glis glis).	in europe, dormice serve as competent reservoir hosts for particular genospecies of the tick-borne agent of lyme disease (ld) and seem to support them more efficiently than do mice or voles. the longevity of edible dormice (glis glis) and their attractiveness for ticks may result in a predominance of ld spirochetes in ticks questing in dormouse habitats. to investigate the role of edible dormice in the transmission cycle of ld spirochetes, we sampled skin tissue from the ear pinnae of dormice in ...	0	24705325
level of awareness regarding some zoonotic diseases, among dog owners of ithaca, new york.	worldwide, dogs and cats are the two most common household companion animals. because of this, they can be direct or indirect source of many human infections. fortunately, most of these zoonotic infections can be clinically prevented by appropriate prophylactic interventions.	0	25657956
human infections with borrelia miyamotoi, japan.	we confirmed infection of 2 patients with borrelia miyamotoi in japan by retrospective surveillance of lyme disease patients and detection of b. miyamotoi dna in serum samples. one patient also showed seroconversion for antibody against recombinant glycerophosphodiester phosphodiesterase of b. miyamotoi. indigenous relapsing fever should be considered a health concern in japan.	0	25061761
bartonella spp. bacteremia and rheumatic symptoms in patients from lyme disease-endemic region.	bartonella spp. infection has been reported in association with an expanding spectrum of symptoms and lesions. among 296 patients examined by a rheumatologist, prevalence of antibodies against bartonella henselae, b. koehlerae, or b. vinsonii subsp. berkhoffii (185 [62%]) and bartonella spp. bacteremia (122 [41.1%]) was high. conditions diagnosed before referral included lyme disease (46.6%), arthralgia/arthritis (20.6%), chronic fatigue (19.6%), and fibromyalgia (6.1%). b. henselae bacteremia w ...	0	22516098
spatially-explicit simulation modeling of ecological response to climate change: methodological considerations in predicting shifting population dynamics of infectious disease vectors.	poikilothermic disease vectors can respond to altered climates through spatial changes in both population size and phenology. quantitative descriptors to characterize, analyze and visualize these dynamic responses are lacking, particularly across large spatial domains. in order to demonstrate the value of a spatially explicit, dynamic modeling approach, we assessed spatial changes in the population dynamics of ixodes scapularis, the lyme disease vector, using a temperature-forced population mode ...	0	24772388
geographical and environmental factors driving the increase in the lyme disease vector ixodes scapularis.	the population densities of many organisms have changed dramatically in recent history. increases in the population density of medically relevant organisms are of particular importance to public health as they are often correlated with the emergence of infectious diseases in human populations. our aim is to delineate increases in density of a common disease vector in north america, the blacklegged tick, and to identify the environmental factors correlated with these population dynamics. empirica ...	0	24371541