Publications

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role of the spike glycoprotein of human middle east respiratory syndrome coronavirus (mers-cov) in virus entry and syncytia formation.little is known about the biology of the emerging human group c betacoronavirus, middle east respiratory syndrome coronavirus (mers-cov). because coronavirus spike glycoproteins (s) mediate virus entry, affect viral host range, and elicit neutralizing antibodies, analyzing the functions of mers-cov s protein is a high research priority. mers-cov s on lentivirus pseudovirions mediated entry into a variety of cell types including embryo cells from new world eptesicus fuscus bats. surprisingly, a p ...201324098509
generation and characterization of eptesicus fuscus (big brown bat) kidney cell lines immortalized using the myotis polyomavirus large t-antigen.it is speculated that bats are important reservoir hosts for numerous viruses, with 27 viral families reportedly detected in bats. majority of these viruses have not been isolated and there is little information regarding their biology in bats. establishing a well-characterized bat cell line supporting the replication of bat-borne viruses would facilitate the analysis of virus-host interactions in an in vitro model. currently, few bat cell lines have been developed and only tb1-lu, derived from ...201627639955
selection of viral variants during persistent infection of insectivorous bat cells with middle east respiratory syndrome coronavirus.coronaviruses that cause severe acute respiratory syndrome (sars) and middle east respiratory syndrome (mers) are speculated to have originated in bats. the mechanisms by which these viruses are maintained in individuals or populations of reservoir bats remain an enigma. mathematical models have predicted long-term persistent infection with low levels of periodic shedding as a likely route for virus maintenance and spillover from bats. in this study, we tested the hypothesis that bat cells and m ...202032350357
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