Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| characterization and applications of a crimean-congo hemorrhagic fever virus nucleoprotein-specific affimer: inhibitory effects in viral replication and development of colorimetric diagnostic tests. | crimean-congo hemorrhagic fever orthonairovirus (cchfv) is one of the most widespread medically important arboviruses, causing human infections that result in mortality rates of up to 60%. we describe the selection of a high-affinity small protein (affimer-np) that binds specifically to the nucleoprotein (np) of cchfv. we demonstrate the interference of affimer-np in the rna-binding function of cchfv np using fluorescence anisotropy, and its inhibitory effects on cchfv gene expression in mammali ... | 2020 | 32492018 |
| nosocomial transmission of emerging viruses via aerosol-generating medical procedures. | recent nosocomial transmission events of emerging and re-emerging viruses, including ebola virus, middle east respiratory syndrome coronavirus, nipah virus, and crimean-congo hemorrhagic fever orthonairovirus, have highlighted the risk of nosocomial transmission of emerging viruses in health-care settings. in particular, concerns and precautions have increased regarding the use of aerosol-generating medical procedures when treating patients with such viral infections. in spite of increasing asso ... | 2019 | 31614743 |
| development of multispecies recombinant nucleoprotein-based indirect elisa for high-throughput screening of crimean-congo hemorrhagic fever virus-specific antibodies. | crimean-congo hemorrhagic fever (cchf) is a re-emerging zoonotic viral disease prevalent in many parts of asia, europe, and africa. the causative agent, crimean-congo hemorrhagic fever orthonairovirus (cchfv), is transmitted through hard ticks. tick vectors especially belonging to the hyalomma species serve as the reservoir and amplifying host. the vertebrate animals including sheep, goat, and bovine act as a short-lasting bridge linking the virus and ticks. cchfv causes fatal hemorrhagic fever ... | 2019 | 31507540 |
| characterization of biomarker levels in crimean-congo hemorrhagic fever and hantavirus fever with renal syndrome. | hemorrhagic fever with renal syndrome (hfrs) and crimean-congo hemorrhagic fever (cchf) are important viral hemorrhagic fevers (vhf), especially in the balkan region. infections with dobrava or puumala orthohantavirus and crimean-congo hemorrhagic fever orthonairovirus can vary from a mild, nonspecific febrile illness, to a severe disease with a fatal outcome. the pathogenesis of both diseases is poorly understood, but it has been suggested that a host's immune mechanism might influence the path ... | 2019 | 31357521 |
| evaluation of crimean-congo hemorrhagic fever orthonairovirus avitagged nucleoprotein for potential application in diagnosis | crimean-congo hemorrhagic fever (cchf) is an acute viral zoonotic disease, with a mortality rate of 30-50%. there is no approved vaccine or any specific antiviral treatment for cchf; therefore, the rapid diagnosis seems to be crucial for both efficient supportive therapy and control of infection spread. in this study, the potency of recombinant nucleoprotein of virus expressed in prokaryotic system was investigated for diagnosis of the infection. | 2019 | 31104398 |
| viral metagenomics, genetic and evolutionary characteristics of crimean-congo hemorrhagic fever orthonairovirus in humans, kosovo. | crimean-congo hemorrhagic fever orthonairovirus (cchfv) is a tick-borne virus which causes severe disease in humans with fatality cases up to 30%. we investigated the genetic and evolutionary characteristics of cchfv in kosovo, in particular in humans and found that different virus variants of genotype v circulate, with turkey as a possible origin for the progenitor of southern european cchf outbreaks. phylogenetic analyses also revealed a single introduction event and in situ evolution of cchfv ... | 2018 | 30006045 |
| serological evidence of rift valley fever phlebovirus and crimean-congo hemorrhagic fever orthonairovirus infections among pygmies in the east region of cameroon. | rift valley fever phlebovirus (rvfv) and crimean-congo hemorrhagic fever orthonairovirus (cchfv) specific antibodies had been documented among humans in urban settings of the southwestern and northern cameroon in the late 1980s. recently, evidence for enzootic circulation of rvfv was reported among livestock in both rural and urban settings in cameroon. however, current estimates of human exposure to rvfv and cchfv are still to be documented in cameroon, especially in rural areas. the aim of thi ... | 2018 | 29625611 |
| a novel double-antigen sandwich elisa for the species-independent detection of crimean-congo hemorrhagic fever virus-specific antibodies. | crimean-congo hemorrhagic fever (cchf) is a tick-borne disease in humans caused by the cchf virus (cchfv). the detection of anti-cchfv antibodies in animals is used to reveal infection risk areas. therefore a simple, quick and reliable multispecies assay for the detection of cchfv-specific antibodies is needed. this work presents the development and validation of a novel cchf double-antigen elisa for the detection of anti-cchfv nucleoprotein antibodies. the test requires 30 μl of serum, and resu ... | 2018 | 29330092 |
| monitoring for the possible introduction of crimean-congo haemorrhagic fever virus in italy based on tick sampling on migratory birds and serological survey of sheep flocks. | crimean-congo haemorrhagic fever (cchf), endemic in africa, asia, eastern europe and the middle east, is caused by a tibovirus (cchfv) transmitted in particular by the hyalomma genus of the ixodidae family that can remain attached to the host for up to 26days, which in case of migratory birds allows long distance carriage. although cchf in domestic ruminants is usually subclinical, they may become reservoirs and act as sentinels for the introduction and/or circulation of cchfv. in this study, po ... | 2018 | 29290300 |
| long-lived cd8+ t cell responses following crimean-congo haemorrhagic fever virus infection. | crimean-congo haemorrhagic fever virus (cchfv) is a member of the orthonairovirus genus of the nairoviridae family and is associated with haemorrhagic fever in humans. although t lymphocyte responses are known to play a role in protection from and clearance of viral infections, specific t cell epitopes have yet to be identified for cchfv following infection. a panel of overlapping peptides covering the cchfv nucleoprotein and the structural glycoproteins, gn and gc, were screened by elispot assa ... | 2017 | 29261651 |
| translating predictions of zoonotic viruses for policymakers. | recent outbreaks of ebola virus disease and zika virus disease highlight the need for disseminating accurate predictions of emerging zoonotic viruses to national governments for disease surveillance and response. although there are published maps for many emerging zoonotic viruses, it is unknown if there is agreement among different models or if they are concordant with national expert opinion. therefore, we reviewed existing predictions for five high priority emerging zoonotic viruses with nati ... | 2017 | 29230614 |
| arboviruses and their related infections in china: a comprehensive field and laboratory investigation over the last 3 decades. | since the 1980s, a comprehensive field and laboratory investigation has been conducted throughout china, and a total of 29 virus species belonging to 7 families and 13 genera were identified through virological, morphological, and immunological methods, as well as whole-genome sequencing and molecular genetic analyses. most of the virus isolates belong to 9 genera in the families flaviviridae, bunyaviridae, togaviridae, and reoviridae. among them, 4 genera (orthobunyavirus, bunyavirus, phlebovir ... | 2018 | 29210509 |
| analysis of codon usage bias of crimean-congo hemorrhagic fever virus and its adaptation to hosts. | crimean-congo hemorrhagic fever virus (cchfv) is a negative-sense, single stranded rna virus with a three-segmented genome that belongs to the genus nairovirus within the family bunyaviridae. cchfv uses hyalomma ticks as a vector to infect humans with a wide range of clinical signs, from asymptomatic to zika-like syndrome. despite significant progress in genomic analyses, the influences of viral relationships with different hosts on overall viral fitness, survival, and evading the host's immune ... | 2017 | 29198972 |
| sequence optimized real-time reverse transcription polymerase chain reaction assay for detection of crimean-congo hemorrhagic fever virus. | crimean-congo hemorrhagic fever virus (cchfv) is a tick-borne virus of the genus nairovirus within the family bunyaviridae. infection can result in general myalgia, fever, and headache with some patients developing hemorrhagic fever with mortality rates ranging from 5% to 30%. cchfv has a wide geographic range that includes africa, asia, the middle east, and europe with nucleotide sequence variation approaching 20% across the three negative-sense rna genome segments. while phylogenetic clusterin ... | 2018 | 29165231 |
| co-circulation of crimean-congo hemorrhagic fever virus strains asia 1 and 2 between the border of iran and pakistan. | crimean-congo hemorrhagic fever (cchf) is a tick-borne viral disease that is transmitted by numerous species of ticks, which serve both as a reservoir and vector of cchf virus (cchfv). molecular and serological tests were undertaken on hard ticks (ixodidae spp.) and samples from livestock were collected in 2015 from chabahar county in southeast iran. using rt-pcr, the ticks were tested for the presence of cchfv. in addition, seven livestock were serologically tested for the presence of igg antib ... | 2017 | 29159319 |
| phylogenetic characterization of crimean-congo hemorrhagic fever virus, spain. | two cases of crimean-congo hemorrhagic fever were reported in spain during 2016. we obtained the virus from a patient sample and characterized its full genomic sequence. phylogenetic analysis indicated that the virus corresponds to the african genotype iii, which includes viruses previously found in west and south africa. | 2017 | 29148370 |
| genome sequences of crimean-congo hemorrhagic fever virus strains isolated in south africa, namibia, and turkey. | we report here the full-length sequences of 16 historical isolates of crimean-congo hemorrhagic fever orthonairovirus (cchfv) obtained in turkey, namibia, and south africa. the strains may be useful for future work to develop molecular diagnostics or viral evolution studies. | 2017 | 29051241 |
| genome sequences of crimean-congo hemorrhagic fever virus strains isolated in south africa, namibia, and turkey. | we report here the full-length sequences of 16 historical isolates of crimean-congo hemorrhagic fever orthonairovirus (cchfv) obtained in turkey, namibia, and south africa. the strains may be useful for future work to develop molecular diagnostics or viral evolution studies. | 2017 | 29051241 |
| lethal infection of embryonated chicken eggs by hazara virus, a model for crimean-congo hemorrhagic fever virus. | hazara virus (hazv) is a member of the genus orthonairovirus of the family nairoviridae. hazv is closely related to crimean-congo hemorrhagic fever virus but differs in that it is non-pathogenic to humans. to establish an infection model system, we tested whether embryonated chicken eggs, which are classically used for evaluating viral pathogenicity, are susceptible to hazv infection. we demonstrated that hazv replicates well in embryonated chicken eggs and kills 100% of the embryos. this can be ... | 2018 | 29030708 |
| a recombinase polymerase amplification assay for rapid detection of crimean-congo haemorrhagic fever virus infection. | crimean-congo haemorrhagic fever virus (cchfv) is a rapidly emerging vector-borne pathogen and the cause of a virulent haemorrhagic fever affecting large parts of europe, africa, the middle east and asia. | 2017 | 29028804 |
| identification of 2'-deoxy-2'-fluorocytidine as a potent inhibitor of crimean-congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus. | crimean-congo hemorrhagic fever virus (cchfv), a tick-borne orthonairovirus, causes a severe hemorrhagic disease in humans (crimean-congo hemorrhagic fever, cchf). currently, no vaccines are approved to prevent cchf; treatment is limited to supportive care and the use of ribavirin, the therapeutic benefits of which remain unclear. cchf is part of who's priority list of infectious diseases warranting further research and development. to aid in the identification of new antiviral compounds, we gen ... | 2017 | 29024765 |
| structure-function assays for crimean-congo hemorrhagic fever virus polymerase. | the recently developed crimean-congo hemorrhagic fever virus (cchfv) reverse genetics systems have paved the way for experiments looking to identify and characterize the roles played by viral and cellular proteins in the cchfv life cycle. in particular, the development of the noninfectious minigenome and virus-like particle (vlp) systems is a tremendous technological advance, as these systems allow for precisely targeting proteins or nucleic acids and measuring the effects these mutations or tre ... | 2018 | 28986838 |
| a mini-review of bunyaviruses recorded in india. | newly emerging and re-emerging viral infections are of major public health concern. bunyaviridae family of viruses comprises a large group of animal viruses. clinical symptoms exhibited by persons infected by viruses belonging to this family vary from mild-to-severe diseases i.e., febrile illness, encephalitis, haemorrhagic fever and acute respiratory illness. several arthropods-borne viruses have been discovered and classified at serological level in india in the past. some of these are highly ... | 2017 | 28948950 |
| a dna vaccine for crimean-congo hemorrhagic fever protects against disease and death in two lethal mouse models. | crimean-congo hemorrhagic fever virus (cchfv) is a tick-borne virus capable of causing a severe hemorrhagic fever disease in humans. there are currently no licensed vaccines to prevent cchfv-associated disease. we developed a dna vaccine expressing the m-segment glycoprotein precursor gene of cchfv and assessed its immunogenicity and protective efficacy in two lethal mouse models of disease: type i interferon receptor knockout (ifnar-/-) mice; and a novel transiently immune suppressed (is) mouse ... | 2017 | 28922426 |
| crimean-congo hemorrhagic fever virus nucleocapsid protein has dual rna binding modes. | crimean congo hemorrhagic fever, a zoonotic viral disease, has high mortality rate in humans. there is currently no vaccine for crimean congo hemorrhagic fever virus (cchfv) and chemical interventions are limited. the three negative sense genomic rna segments of cchfv are specifically encapsidated by the nucleocapsid protein into three ribonucleocapsids, which serve as templates for the viral rna dependent rna polymerase. here we demonstrate that cchfv nucleocapsid protein has two distinct bindi ... | 2017 | 28922369 |
| molecular detection of crimean-congo hemorrhagic fever virus in ticks, greece, 2012-2014. | crimean-congo hemorrhagic fever virus (cchfv) is transmitted to humans mainly through the bite of infected ticks. in greece, only one clinical case has been observed, in 2008, but the seroprevalence in humans is relatively high (4.2%). to have a first insight into the circulation of cchfv in greece, 2000 ticks collected from livestock during 2012-2014 were tested. cchfv was detected in 36 of the 1290 (2.8%) tick pools (1-5 ticks per pool). two genetic lineages were identified: europe 1 and europ ... | 2017 | 28920177 |
| crimean-congo hemorrhagic fever virus suppresses innate immune responses via a ubiquitin and isg15 specific protease. | antiviral responses are regulated by conjugation of ubiquitin (ub) and interferon-stimulated gene 15 (isg15) to proteins. certain classes of viruses encode ub- or isg15-specific proteases belonging to the ovarian tumor (otu) superfamily. their activity is thought to suppress cellular immune responses, but studies demonstrating the function of viral otu proteases during infection are lacking. crimean-congo hemorrhagic fever virus (cchfv, family nairoviridae) is a highly pathogenic human virus tha ... | 2017 | 28877473 |
| effect of tlr10 (2322a/g, 720a/c and 992t/a) polymorphisms on the pathogenesis of crimean congo hemorrhagic fever disease. | crimean congo hemorrhagic fever (cchf) is a tick-borne disease caused by the crimean congo hemorrhagic fever virus (cchfv). toll-like receptors (tlrs) are type 1 transmembrane proteins of immune cells that play a critical role in innate and adaptive immunity. the present study first time aims to investigate the relation between tlr10 gene polymorphisms (720a/c, 992t/a and 2322a/g), severity/non-severity, fatality/non-fatality and ccfh disease by using pcr-rflp assay in a turkish population. tlr1 ... | 2017 | 28843003 |
| identification of broadly neutralizing monoclonal antibodies against crimean-congo hemorrhagic fever virus. | despite the serious public health impact of crimean-congo hemorrhagic fever (cchf), the efficacy of antivirals targeting the causative agent, cchf virus (cchfv), remains debatable. neutralizing monoclonal antibodies (mabs) targeting the cchfv glycoprotein gc have been reported to protect mice against challenge with the prototype cchfv strain, ibar10200. however, due to extensive sequence diversity of cchfv glycoproteins, it is unknown whether these mabs neutralize other cchfv strains. we initial ... | 2017 | 28842265 |
| genomic characterization of crimean-congo hemorrhagic fever virus in hyalomma tick from spain, 2014. | crimean-congo hemorrhagic fever (cchf) is a severe tick-borne disease caused by cchf virus (cchfv). ticks in the genus hyalomma are the main vectors and reservoirs of cchfv. in spain, cchfv was first detected in hyalomma ticks from cáceres in 2010. subsequently, two autochthonous cchf cases were reported in august 2016. in this study, we describe the characterization of the cchfv genome directly from hyalomma lusitanicum collected in cáceres in 2014. phylogenetic analyses reveal a close relation ... | 2017 | 28836897 |
| crimean-congo hemorrhagic fever virus in ticks collected from livestock in albania. | albania is a balkan country endemic for crimean-congo hemorrhagic fever (cchf). it was shown previously that cchf virus (cchfv) sequences from albanian patients cluster into europe 1 clade. aim of the present study was to test for cchfv ticks collected in several regions of albania, and to determine the genetic lineage(s) of the cchfv strains in relation with their geographic distribution. a total of 726 ticks (366 hyalomma marginatum, 349 rhipicephalus bursa and 11 rhipicephalus sanguineus) col ... | 2017 | 28827176 |
| crimean congo hemorrhagic fever among the one-humped camel (camelus dromedaries) in central sudan. | crimean-congo hemorrhagic fever (cchf) is a tick-borne viral zoonotic disease caused by crimean-congo hemorrhagic fever virus (cchfv), a member of the genus nairovirus in the family bunyaviridae. cchf is typically asymptomatic in animals but can be highly fatal in humans approaching case fatality rate of approximately 30%. in the present investigation, a cross sectional study was conducted to determine the prevalence of cchf and to identify the potential risk factors associated with cchfv seropo ... | 2017 | 28774342 |
| a comprehensive review of common bacterial, parasitic and viral zoonoses at the human-animal interface in egypt. | egypt has a unique geographical location connecting the three old-world continents africa, asia and europe. it is the country with the highest population density in the middle east, northern africa and the mediterranean basin. this review summarizes the prevalence, reservoirs, sources of human infection and control regimes of common bacterial, parasitic and viral zoonoses in animals and humans in egypt. there is a gap of knowledge conerning the epidemiology of zoonotic diseases at the human-anim ... | 2017 | 28754024 |
| combination of rt-pcr and proteomics for the identification of crimean-congo hemorrhagic fever virus in ticks. | crimean-congo hemorrhagic fever (cchf) is an emerging tick-borne zoonotic disease caused by the cchf virus (cchfv). in this study, an experimental approach combining rt-pcr and proteomics was used for the identification and characterization of cchfv in 106 ticks from 7 species that were collected from small ruminants in greece. the methodological approach included an initial screening for cchfv by rt-pcr followed by proteomics analysis of positive and control negative tick samples. this novel ap ... | 2017 | 28736753 |
| serosurvey of crimean-congo hemorrhagic fever virus in cattle, mali, west africa. | abstractcrimean-congo hemorrhagic fever is a tick-borne disease caused by the arbovirus crimean-congo hemorrhagic fever virus (cchfv, family bunyaviridae, genus nairovirus). cchfv can cause a severe hemorrhagic fever with high-case fatality rates in humans. cchfv has a wide geographic range and has been described in around 30 countries in the middle east, asia, europe, and africa including mali and neighboring countries. to date, little is known about the prevalence rates of cchfv in mali. here, ... | 2017 | 28719259 |
| serosurvey for crimean-congo hemorrhagic fever virus infections in ruminants in katanga province, democratic republic of the congo. | crimean-congo hemorrhagic fever virus (cchfv) has been detected in many african countries. unfortunately, little is known about the current cchfv situation in most of those countries including the democratic republic of the congo (drc). in over 50 years, three human cchf cases have been detected in drc but no seroepidemiological investigation was performed so far. to determine the prevalence of cchfv-specific antibodies we tested 838 serum samples of cattle, goat and sheep from the southern prov ... | 2017 | 28712556 |
| francisella-like endosymbionts and rickettsia species in local and imported hyalomma ticks. | hyalomma ticks (acari: ixodidae) are hosts for francisella-like endosymbionts (fle) and may serve as vectors of zoonotic disease agents. this study aimed to provide an initial characterization of the interaction between hyalomma and fle and to determine the prevalence of pathogenic rickettsia in these ticks. hyalomma marginatum, hyalomma rufipes, hyalommadromedarii, hyalommaaegyptium, and hyalommaexcavatum ticks, identified morphologically and molecularly, were collected from different hosts and ... | 2017 | 28710265 |
| tetracyclines as a potential antiviral therapy against crimean congo hemorrhagic fever virus: docking and molecular dynamic studies. | crimean-congo hemorrhagic fever virus (cchfv) is one of the deadliest human diseases with mortality rate near 50%. special attention should be paid to this virus since there is no approved treatment for it. on the other hand, the recent outbreak of ebola virus which is a member of hemorrhagic fever viruses shows this group of viruses can be extremely dangerous. previous studies have indicated that nucleoprotein of cchfv, a pivotal protein in virus replication, is an appropriate target for antivi ... | 2017 | 28709136 |
| generic amplification and next generation sequencing reveal crimean-congo hemorrhagic fever virus ap92-like strain and distinct tick phleboviruses in anatolia, turkey. | ticks are involved with the transmission of several viruses with significant health impact. as incidences of tick-borne viral infections are rising, several novel and divergent tick- associated viruses have recently been documented to exist and circulate worldwide. this study was performed as a cross-sectional screening for all major tick-borne viruses in several regions in turkey. next generation sequencing (ngs) was employed for virus genome characterization. ticks were collected at 43 locatio ... | 2017 | 28705183 |
| development of vaccines against crimean-congo haemorrhagic fever virus. | crimean-congo haemorrhagic fever virus (cchfv) is a deadly human pathogen of the utmost seriousness being highly lethal causing devastating disease symptoms that result in intense and prolonged suffering to those infected. during the past 40years, this virus has repeatedly caused sporadic outbreaks responsible for relatively low numbers of human casualties, but with an alarming fatality rate of up to 80% in clinically infected patients. cchfv is transmitted to humans by hyalomma ticks and contac ... | 2017 | 28687403 |
| microbiological zoonotic emerging risks, transmitted between livestock animals and humans (2007-2015). | as part of the emerging risk identification (eri) activities of the european food safety authority (efsa), a literature search was conducted to identify the microbiological agents transmitted between livestock animals and humans that have been suggested as having emerged between 2007 and 2015 in peer-reviewed scientific literature published during the same period (2007-2015). according to the criteria set, the search identified seven such zoonotic agents, namely west nile fever virus, rift valle ... | 2017 | 28670863 |
| importance of endothelial dysfunction biomarkers in patients with crimean-congo hemorrhagic fever. | the pathogenesis of the crimean-congo hemorrhagic fever (cchf) and the cause of the hemorrhage are not yet fully understood. however, the endothelium plays a key role in the pathogenesis. the purpose of this study was to investigate endothelial dysfunction markers (asymmetrical dimethyl arginine [adma], endothelin 1[et-1], thrombomodulin [tm], von willebrand factor [vwf], and intercellular adhesion molecule [icam-1]) in serum in patients with cchf and their associations with hemorrhage. seventy- ... | 2017 | 28628220 |
| crimean-congo hemorrhagic fever virus-specific antibody detection in cattle in mauritania. | crimean-congo hemorrhagic fever virus (cchfv) was detected for the first time in mauritania in 1983 and several cchfv outbreaks were reported in the following years. the last human case was diagnosed in 2015. however, no recent data exist about the prevalence of cchfv in animals, although it is already described that prevalence studies in animals serve as good risk indicators. cchfv can cause a severe hemorrhagic fever with a high case fatality rate in humans. therefore, a precise risk assessmen ... | 2017 | 28605299 |
| crimean-congo hemorrhagic fever: tick-host-virus interactions. | crimean-congo hemorrhagic fever virus (cchfv) is transmitted to humans by bite of infected ticks or by direct contact with blood or tissues of viremic patients or animals. it causes to humans a severe disease with fatality up to 30%. the current knowledge about the vector-host-cchfv interactions is very limited due to the high-level containment required for cchfv studies. among ticks, hyalomma spp. are considered the most competent virus vectors. cchfv evades the tick immune response, and follow ... | 2017 | 28603698 |
| draft genome sequences of eight crimean-congo hemorrhagic fever virus strains. | crimean-congo hemorrhagic fever virus (cchfv) is a geographically widespread rna virus with a high degree of genomic diversity that complicates sequence-based diagnostics. here, we sequenced eight cchfv strains for improved assay design and deposition into fda-argos, the fda's pathogen database for development and verification of next generation sequencing assays. | 2017 | 28596387 |
| the role of ticks in the maintenance and transmission of crimean-congo hemorrhagic fever virus: a review of published field and laboratory studies. | this manuscript is part of a series of reviews that aim to cover published research on crimean-congo hemorrhagic fever (cchf) and its etiological agent, cchf virus (cchfv). the virus is maintained and transmitted in a vertical and horizontal transmission cycle involving a variety of wild and domestic vertebrate species that act as amplification hosts, without showing signs of illness. these vertebrates have traditionally been considered reservoirs of cchfv, but in fact they develop only a transi ... | 2017 | 28579441 |
| cytokine response in crimean-congo hemorrhagic fever virus infection. | we described the predictive role of cytokines in fatality of crimean congo hemorrhagic fever virus (cchfv) infection by using daily clinical sera samples. consequent serum samples of the selected patients in different severity groups and healthy controls were examined by using human cytokine 17-plex assay. we included 12 (23%) mild, 30 (58%) moderate, 10 (19%) severe patients, and 10 healthy volunteers. the mean age of the patients was 52 (sd 15), 52% were female. forty-six patients (88%) receiv ... | 2017 | 28547808 |
| potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants. | the recent middle east respiratory syndrome coronavirus (mers-cov), ebola and zika virus outbreaks exemplify the continued threat of (re-)emerging viruses to human health, and our inability to rapidly develop effective therapeutic countermeasures. many viruses, including mers-cov and the crimean-congo hemorrhagic fever virus (cchfv) encode deubiquitinating (dub) enzymes that are critical for viral replication and pathogenicity. they bind and remove ubiquitin (ub) and interferon stimulated gene 1 ... | 2017 | 28542609 |
| development and evaluation of a bioinformatics approach for designing molecular assays for viral detection. | viruses belonging to the flaviviridae and bunyaviridae families show considerable genetic diversity. however, this diversity is not necessarily taken into account when developing diagnostic assays, which are often based on the pairwise alignment of a limited number of sequences. our objective was to develop and evaluate a bioinformatics workflow addressing two recurrent issues of molecular assay design: (i) the high intraspecies genetic diversity in viruses and (ii) the potential for cross-react ... | 2017 | 28542435 |
| crimean-congo hemorrhagic fever in migrant worker returning from oman to india, 2016. | in january 2016, a migrant worker who returned home to india after becoming ill in oman was confirmed to have crimean-congo hemorrhagic fever (cchf). physicians should include cchf in the differential diagnosis for patients with hemorrhagic signs and a history of recent travel to any area where cchf is endemic or prevalent. | 2017 | 28518037 |
| crimean-congo hemorrhagic fever virus nucleocapsid protein augments mrna translation. | crimean-congo hemorrhagic fever virus (cchfv) is a tick-borne nairovirus of the bunyaviridae family, causing severe illness with high mortality rates in humans. here, we demonstrate that cchfv nucleocapsid protein (cchfv-np) augments mrna translation. cchfv-np binds to the viral mrna 5' untranslated region (utr) with high affinity. it facilitates the translation of reporter mrna both in vivo and in vitro with the assistance of the viral mrna 5' utr. cchfv-np equally favors the translation of bot ... | 2017 | 28515298 |
| vector and serologic survey for crimean-congo hemorrhagic fever virus in poland. | in contrast to animals, crimean-congo hemorrhagic fever (cchf) causes a severe disease in humans with a high mortality rate. the etiological agent, cchf virus (cchfv), can be transmitted by argasid and ixodid ticks, but arachnids of the genus hyalomma, followed by rhipicephalus and dermacentor serve as the major vectors of this virus. the goal of the study was to assess the epidemiological situation of cchfv infection in cattle in south-east poland, and survey for potential tick vector species. ... | 2017 | 28514225 |
| detection of a novel putative phlebovirus and first isolation of dugbe virus from ticks in accra, ghana. | ticks are ectoparasites that transmit various types of human and animal pathogens. in particular, emerging and re-emerging diseases caused by tick-borne viruses are public health concerns around the world. however, in many countries of the sub-saharan african region, epidemiological information on tick-borne viral infections is limited, and their prevalence and distribution remain largely unknown. in this study, we conducted surveillance on ticks to detect medically important tick-borne bunyavir ... | 2017 | 28479064 |
| crimean-congo hemorrhagic fever cases in the north of iran have three distinct origins. | an on-going surveillance program on crimean-congo haemorrhagic fever virus (cchfv) in iran has been launched since 2000. an outbreak of cchf occurred in northern iran between june and july 2015. three cases were involved in this outbreak. one patient died after admission to hospital, and the others were treated successfully. phylogenetic analysis showed that three sequences obtained from iranian patients grouped within clade iv (asia-1), clade v (europe) and clade vi (greece). the partial sequen ... | 2017 | 28466055 |
| crimean-congo hemorrhagic fever virus in ticks in turkey: a broad range tick surveillance study. | in turkey, crimean-congo hemorrhagic fever (cchf) outbreaks started in northern regions in 2002. human cases still continue to increase and the disease spreads in many other provinces of turkey. the ecological role of the vector tick species occurring in turkey is not certain exactly. therefore, we planned a broad range tick study in three different ecological and geographical areas extending from the west black sea regions down to the central anatolia. the aim of this study was to determine and ... | 2017 | 28433738 |
| the reasons why pakistan might be at high risk of crimean congo haemorrhagic fever epidemic; a scoping review of the literature. | pakistan has faced a number of significant healthcare challenges over the past decade. in 2000, one of these events - a deadly epidemic of crimean congo haemorrhagic fever (cchf) - struck pakistan. the people of pakistan are at a very high risk of acquiring cchf, due to a number of factors which emerge from a scoping review of the literature. first, the underdeveloped healthcare system of the country is currently not prepared to cope with challenges of this nature. healthcare professionals and m ... | 2017 | 28335777 |
| expression and characterization of codon-optimized crimean-congo hemorrhagic fever virus gn glycoprotein in insect cells. | crimean-congo hemorrhagic fever virus (cchfv) is a major cause of tick-borne viral hemorrhagic disease in the world. despite of its importance as a deadly pathogen, there is currently no licensed vaccine against cchf disease. the attachment glycoprotein of cchfv (gn) is a potentially important target for protective antiviral immune responses. to characterize the expression of recombinant cchfv gn in an insect-cell-based system, we developed a gene expression system expressing the full-length cod ... | 2017 | 28316015 |
| molecular (ticks) and serological (humans) study of crimean-congo hemorrhagic fever virus in the iberian peninsula, 2013-2015. | crimean-congo hemorrhagic fever (cchf) is a viral disease, mainly transmitted through tick bite, of great importance in public health. in spain, crimean-congo hemorrhagic fever virus (cchfv) was detected for the first time in 2010 in hyalomma lusitanicum ticks collected from deer in cáceres. the aim of this study was to investigate the presence of cchfv in ticks from cáceres, and from other spanish areas, and to evaluate the presence of antibodies against the virus in individuals exposed to tick ... | 2017 | 28291670 |
| antiviral activity of cationic amphiphilic drugs. | emerging and reemerging viral infections represent a major concern for human and veterinary public health and there is an urgent need for the development of broad-spectrum antivirals. areas covered: a recent strategy in antiviral research is based on the identification of molecules targeting host functions required for infection of multiple viruses. a number of fda-approved drugs used to treat several human diseases are cationic amphiphilic drugs (cads) that have the ability to accumulate inside ... | 2017 | 28286997 |
| detection of crimean-congo hemorrhagic fever virus-specific igg antibodies in ruminants residing in central and western macedonia, greece. | crimean-congo hemorrhagic fever virus (cchfv) is a tick-borne virus which causes lethal hemorrhagic fever in humans. although, several reports regarding cchfv antibody prevalence in humans exist in greece, information about the current distribution is limited. the aim of the present study is to investigate the prevalence of cchfv-specific igg antibodies in cattle and sheep in macedonia-greece. the samplings were performed during spring 2013, in 5 regional units of central macedonia (chalkidiki, ... | 2017 | 28286143 |
| current status of crimean-congo haemorrhagic fever in the world health organization eastern mediterranean region: issues, challenges, and future directions. | crimean-congo haemorrhagic fever (cchf) is the most widespread, tick-borne viral disease affecting humans. the disease is endemic in many regions, such as africa, asia, eastern and southern europe, and central asia. recently, the incidence of cchf has increased rapidly in the countries of the world health organization eastern mediterranean region (who emr), with sporadic human cases and outbreaks of cchf being reported from a number of countries in the region. despite the rapidly growing inciden ... | 2017 | 28259724 |
| a new strain of crimean-congo hemorrhagic fever virus isolated from xinjiang, china. | crimean-congo hemorrhagic fever virus (cchfv) is a highly pathogenic tick-borne virus with a fatality rate of up to 50% in humans. cchfv is widely distributed in countries around the world. outbreaks of cchfv infection in humans have occurred in prior years in xinjiang province, china. epidemiological surveys have detected cchfv rna in ticks and animals; however, few isolates were identified. in this study, we identified and isolated a new cchfv strain from hyalomma asiaticum asiaticum ticks col ... | 2017 | 28251517 |
| immunization with dna plasmids coding for crimean-congo hemorrhagic fever virus capsid and envelope proteins and/or virus-like particles induces protection and survival in challenged mice. | crimean congo hemorrhagic fever virus (cchfv) is a bunyavirus causing severe hemorrhagic fever disease in humans, with high mortality rates. the requirement of high-containment laboratory and the lack of animal model hampered the study of the immune response and protection of vaccine candidates.using the recently developed interferon-alpha-receptor knock-out (ifnar -/-) mouse model, which replicates human disease, we investigated the immunogenicity and protection of two novel cchfv vaccine candi ... | 2017 | 28250124 |
| crimean-congo hemorrhagic fever virus in pakistan. | the crimean-congo hemorrhagic fever is a zoonotic disease transmitted by ticks and is characterized by fever and bleeding. it was seen for the first time in the south of present day ukraine and thus named, crimean fever. 1 in 1956, the virus was isolated in a patient with similar symptoms residing in congo, kenya and the virus was named congo virus. the viruses causing these two diseases were the same and hence was termed crimean-congo hemorrhagic fever virus (cchfv). humans are the only known h ... | 2017 | 28124602 |
| crimean-congo haemorrhagic fever virus and eid-ul-adha festival in pakistan. | 2016 | 27998596 | |
| serological and virological evidence of crimean-congo haemorrhagic fever virus circulation in the human population of borno state, northeastern nigeria. | despite several studies on the seroprevalence of antibodies against crimean-congo haemorrhagic fever virus (cchfv) from humans and cattle in nigeria, detailed investigation looking at igg and igm have not been reported. additionally, there have been no confirmed cases of human cchfv infection reported from nigeria. | 2016 | 27926935 |
| phylogeography of crimean congo hemorrhagic fever virus. | crimean congo hemorrhagic fever virus (cchfv) is one of the most severe viral zoonozes. it is prevalent throughout africa, asia and southern europe. limited availability of sequence data has hindered phylogeographic studies. the complete genomic sequence of all three segments of 14 crimean congo hemorrhagic fever virus strains isolated from 1958-2000 in russia, central asia and africa was identified. each genomic segment was independently subjected to continuous bayesian phylogeographic analysis ... | 2016 | 27880794 |
| crimean-congo hemorrhagic fever among children in iran. | crimean-congo hemorrhagic fever (cchf) is a viral zoonotic disease which is endemic in iran. the etiological agent of cchf is an rna virus belonging to the genus nairovirus of the family bunyaviridae. cchf virus (cchfv) can be transmitted to humans through bites from infected ticks and direct contact with infected blood or tissues. although the disease has been observed in different age groups, the rate of disease is lower in children and elderly. this study was designed to characterize cchfv-in ... | 2017 | 27878461 |
| include crimean-congo haemorrhagic fever virus prevention in pre-travel advice. | 2017 | 27794472 | |
| transstadial transmission and long-term association of crimean-congo hemorrhagic fever virus in ticks shapes genome plasticity. | the trade-off hypothesis, the current paradigm of arbovirus evolution, proposes that cycling between vertebrate and invertebrate hosts presents significant constraints on genetic change of arboviruses. studying these constraints in mosquito-borne viruses has led to a new understanding of epizootics. the trade-off hypothesis is assumed to be applicable to tick-borne viruses too, although studies are lacking. tick-borne crimean-congo hemorrhagic fever virus (cchfv), a member of the family bunyavir ... | 2016 | 27775001 |
| serosurveillance of viral pathogens circulating in west africa. | sub-saharan africa is home to a variety of pathogens, but disease surveillance and the healthcare infrastructure necessary for proper management and control are severely limited. lassa virus, the cause of lassa fever, a severe hemorrhagic fever in humans is endemic in west africa. in sierra leone at the kenema government hospital lassa diagnostic laboratory, up to 70 % of acute patient samples suspected of lassa fever test negative for lassa virus infection. this large amount of acute undiagnose ... | 2016 | 27716429 |
| a chronological review of experimental infection studies of the role of wild animals and livestock in the maintenance and transmission of crimean-congo hemorrhagic fever virus. | this article provides a definitive review of experimental studies of the role of wild animals and livestock in the maintenance and transmission of crimean-congo hemorrhagic fever virus (cchfv), the etiologic agent of crimean-congo hemorrhagic fever (cchf), beginning with the first recognized outbreak of the human disease in crimea in 1944. published reports by researchers in the former soviet union, bulgaria, south africa, and other countries where cchf has been observed show that cchfv is maint ... | 2016 | 27713073 |
| ticks threatening lineage of anatolian wild sheep (ovis gmelinii anatolica) and determination of their tick-borne pathogens. | we aimed to determine the ticks of the anatolian wild sheep and to define their tick-borne pathogens while molecularly studying their relationships with those of the domestic sheep. furthermore, another aim of this study is to investigate tick paralysis resulting in the death of the anatolian wild sheep. ticks and blood samples were collected from the wild sheep whilst tick samples were also collected from hares, guinea fowls, chickens, and a turkey living in the anatolian wild sheep breeding ar ... | 2016 | 27692336 |
| biosafety standards for working with crimean-congo hemorrhagic fever virus. | in countries from which crimean-congo haemorrhagic fever (cchf) is absent, the causative virus, cchf virus (cchfv), is classified as a hazard group 4 agent and handled in containment level (cl)-4. in contrast, most endemic countries out of necessity have had to perform diagnostic tests under biosafety level (bsl)-2 or -3 conditions. in particular, turkey and several of the balkan countries have safely processed more than 100 000 samples over many years in bsl-2 laboratories. it is therefore advo ... | 2016 | 27667586 |
| molecular basis for the formation of ribonucleoprotein complex of crimean-congo hemorrhagic fever virus. | negative-sense single-strand rna (-ssrna) viruses comprise a large family of pathogens that cause severe human infectious diseases. all -ssrna viruses encode a nucleocapsid protein (np) to encapsidate the viral genome, which, together with polymerase, forms a ribonucleoprotein complex (rnp) that is packaged into virions and acts as the template for viral replication and transcription. in our previous work, we solved the monomeric structure of np encoded by crimean-congo hemorrhagic fever virus ( ... | 2016 | 27666016 |
| a competitive elisa for species-independent detection of crimean-congo hemorrhagic fever virus specific antibodies. | crimean-congo hemorrhagic fever virus (cchfv) circulates in many countries of asia, africa, and europe. cchfv can cause a severe hemorrhagic fever in humans with case-fatality rates of up to 80%. cchf is considered to be one of the major emerging diseases spreading to and within europe. ticks of the genus hyalomma function as vector as well as natural reservoir of cchfv. ticks feed on various domestic animals (e.g. cattle, sheep, goats) and on wildlife (e.g. hares, hedgehogs). those animal speci ... | 2016 | 27623345 |
| transmission and evolution of tick-borne viruses. | ticks transmit a diverse array of viruses such as tick-borne encephalitis virus, powassan virus, and crimean-congo hemorrhagic fever virus that are reemerging in many parts of the world. most tick-borne viruses (tbvs) are rna viruses that replicate using error-prone polymerases and produce genetically diverse viral populations that facilitate their rapid evolution and adaptation to novel environments. this article reviews the mechanisms of virus transmission by tick vectors, the molecular evolut ... | 2016 | 27569396 |
| molecular epidemiology of crimean-congo haemorrhagic fever virus in india. | crimean-congo haemorrhagic fever (cchf) is an emerging zoonotic disease in india which is prevalent in neighbouring countries. cchf virus (cchfv) is a widespread tick-borne virus which is endemic in africa, asia, eastern europe and the middle east. in the present study, samples of clinically suspected human cases from different areas of northern-western india were tested for the presence of cchfv by rt-pcr through amplification of nucleocapsid (n) gene of cchfv. positive samples were sequenced t ... | 2016 | 27523802 |
| companion animals as a source of viruses for human beings and food production animals. | companion animals comprise a wide variety of species, including dogs, cats, horses, ferrets, guinea pigs, reptiles, birds and ornamental fish, as well as food production animal species, such as domestic pigs, kept as companion animals. despite their prominent place in human society, little is known about the role of companion animals as sources of viruses for people and food production animals. therefore, we reviewed the literature for accounts of infections of companion animals by zoonotic viru ... | 2016 | 27522300 |
| heat shock protein 70 family members interact with crimean-congo hemorrhagic fever virus and hazara virus nucleocapsid proteins and perform a functional role in the nairovirus replication cycle. | the nairovirus genus of the bunyaviridae family contains serious human and animal pathogens classified within multiple serogroups and species. of these serogroups, the crimean-congo hemorrhagic fever virus (cchfv) serogroup comprises sole members cchfv and hazara virus (hazv). cchfv is an emerging zoonotic virus that causes often-fatal hemorrhagic fever in infected humans for which preventative or therapeutic strategies are not available. in contrast, hazv is nonpathogenic to humans and thus rep ... | 2016 | 27512070 |
| crimean congo hemorrhagic fever virus and alkhurma (alkhumra) virus in ticks in djibouti. | crimean congo hemorrhagic fever virus and alkhumra virus, not previously reported in djibouti, were detected among 141 (infection rate = 15.7 per 100, 95% ci: 13.4-18.1) tick pools from 81 (37%) cattle and 2 (infection rate = 0.2 per 100, 95% ci: 0.0-0.7) tick pools from 2 (1%) cattle, respectively, collected at an abattoir in 2010 and 2011. | 2016 | 27508862 |
| phylogeny of tick-derived crimean-congo hemorrhagic fever virus strains in iran. | the presence of crimean-congo hemorrhagic fever virus (cchfv) in iran was assessed by collecting ticks from golpayegan, isfahan province. real time rt-pcr was used to detect the cchfv rna in the tick population and the origins of the viral sequences were determined. the cchfv rna was detected in 5.2% of 492 ticks collected from livestock in different regions of golpayegan. the tick species that tested positive for the presence of cchfv rna included hyalomma, rhipicephalus and haemaphysalis speci ... | 2016 | 27491289 |
| plant-produced crimean-congo haemorrhagic fever virus nucleoprotein for use in indirect elisa. | crimean-congo haemorrhagic fever (cchf) is a disease of serious public concern caused by the cchf virus (cchfv). anti-cchfv igg in humans can be detected using elisa with native antigen prepared from cell cultures which have been infected with virus or from brain tissue of suckling mice which have been inoculated with virus. however, the preparation of these reagents requires high biosafety levels and is expensive. a safer, more cost-effective recombinantly-produced np reagent is desirable. rece ... | 2016 | 27474493 |
| crimean-congo hemorrhagic fever virus in bulgaria and turkey. | infections of humans with the tick-borne crimean-congo hemorrhagic fever virus (cchfv) can cause a severe hemorrhagic fever with case fatality rates of up to 80%. most humans are infected by tick bite, crushing infected ticks by hand or by unprotected contact with blood of viremic mammals. next to the notified human cchf cases, the real distribution and the situation in animals in southeastern europe are nearly unknown. since domestic ruminants play a crucial role in the life cycle of the vector ... | 2016 | 27467142 |
| occurrence of hyalomma, (acari: ixodidae) koch, 1844 on domestic animal in the union territory of dadra & nagar haveli, indian. | in response to recent outbreak of crimean-congo hemorrhagic fever (cchf) in gujarat (india). this investigation was carried out in order to determine the risk of cchf. the prevalence and abundance of hyalomma (acari: ixodidae) were recorded on the domestic animals in the union territory of dadra & nagar haveli during the period of january to december 2012. overall, 71 larva and 148 adults belonging to three species of hyalomma viz., hyal. anatolicum anatolicum, hyal. detritum, and hyal. marginat ... | 2016 | 27413337 |
| biochemical and structural insights into the preference of nairoviral deisgylases for interferon-stimulated gene product 15 originating from certain species. | the regulation of the interferon type i (ifn-i) response has been shown to rely on posttranslational modification by ubiquitin (ub) and ub-like interferon-stimulated gene product 15 (isg15) to stabilize, or activate, a variety of ifn-i signaling and downstream effector proteins. unlike ub, which is almost perfectly conserved among eukaryotes, isg15 is highly divergent, even among mammals. since zoonotic viruses rely on viral proteins to recognize, or cleave, isg15 conjugates in order to evade, o ... | 2016 | 27412597 |
| crimean-congo hemorrhagic fever virus in livestock ticks and animal handler seroprevalence at an abattoir in ghana. | crimean-congo haemorrhagic fever virus (cchfv) is a zoonotic virus transmitted by ixodid ticks and causes crimean-congo hemorrhagic fever (cchf) disease in humans with up to 50 % mortality rate. | 2016 | 27392037 |
| crimean-congo hemorrhagic fever virus lineages europe 1 and europe 2 in bulgarian ticks. | crimean-congo hemorrhagic fever (cchf) is a tick-borne human viral disease with fatality rate up to 30%. two genetic lineages of cchf virus (cchfv) are present in europe - lineage europe 1 which contains pathogenic cchfv strains, and lineage europe 2 consisting of ap92 and ap92-like strains. in order to investigate cchfv distribution and potential risk for humans, ticks were collected from livestock in the five districts where cchf cases have been reported in the last five years in bulgaria. cch ... | 2016 | 27378409 |
| seroprevalence of west nile virus, crimean-congo hemorrhagic fever virus, francisella tularensis and borrelia burgdorferi in rural population of manisa, western turkey. | zoonotic diseases are well recognised threat to public health globally. the information of regional prevalence and associated risk factors allow the national programmes to determine and frame better strategies for their control, as they also provide the actual status of zoonosis in the region. the aim of this study was to determine the seroprevalence of west nile virus (wnv), crimean-congo hemorrhagic fever virus (cchfv), francisella tularensis and borrelia burgdorferi among the rural residents ... | 2017 | 27353580 |
| hmgb1 is a potential biomarker for severe viral hemorrhagic fevers. | hemorrhagic fever with renal syndrome (hfrs) and crimean-congo hemorrhagic fever (cchf) are common representatives of viral hemorrhagic fevers still often neglected in some parts of the world. infection with dobrava or puumala virus (hfrs) and crimean-congo hemorrhagic fever virus (cchfv) can result in a mild, nonspecific febrile illness or as a severe disease with hemorrhaging and high fatality rate. an important factor in optimizing survival rate in patients with vhf is instant recognition of ... | 2016 | 27348219 |
| taking forward a 'one health' approach for turning the tide against the middle east respiratory syndrome coronavirus and other zoonotic pathogens with epidemic potential. | the appearance of novel pathogens of humans with epidemic potential and high mortality rates have threatened global health security for centuries. over the past few decades new zoonotic infectious diseases of humans caused by pathogens arising from animal reservoirs have included west nile virus, yellow fever virus, ebola virus, nipah virus, lassa fever virus, hanta virus, dengue fever virus, rift valley fever virus, crimean-congo haemorrhagic fever virus, severe acute respiratory syndrome coron ... | 2016 | 27321961 |
| crimean-congo hemorrhagic fever with acute subdural hematoma, mauritania, 2012. | 2016 | 27315138 | |
| molecular assay on crimean congo hemorrhagic fever virus in ticks (ixodidae) collected from kermanshah province, western iran. | crimean-congo hemorrhagic fever (cchf) is a feverous and hemorrhagic disease endemic in some parts of iran and caused by an arbovirus related to bunyaviridae family and nairovirusgenus. the main virus reservoir in the nature is ticks, however small vertebrates and a wide range of domestic and wild animals are regarded as reservoir hosts. this study was conducted to determine the infection rate of cchf virus in hard ticks of sarpole-zahab county, kermanshah province, west of iran. | 2016 | 27308296 |
| crimean-congo hemorrhagic fever in the one-humped camel (camelus dromedarius) in east and northeast of iran. | this comprehensive study was conducted on multi-purpose one-humped camel (camelus dromedarius) sera and ticks to assess the epidemiological aspects of the crimean-congo hemorrhagic fever virus (cchfv) in northeast iran. | 2016 | 27308275 |
| genetic diversity of crimean congo hemorrhagic fever virus strains from iran. | crimean congo hemorrhagic fever virus (cchfv) is a member of the bunyaviridae family and nairovirus genus. it has a negative-sense, single stranded rna genome approximately 19.2 kb, containing the small, medium, and large segments. cchfvs are relatively divergent in their genome sequence and grouped in seven distinct clades based on s-segment sequence analysis and six clades based on m-segment sequences. our aim was to obtain new insights into the molecular epidemiology of cchfv in iran. | 2016 | 27308271 |
| protective effects of a modified vaccinia ankara-based vaccine candidate against crimean-congo haemorrhagic fever virus require both cellular and humoral responses. | crimean-congo haemorrhagic fever (cchf) is a severe tick-borne disease, endemic in many countries in africa, the middle east, eastern europe and asia. there is no approved vaccine currently available against cchf. the most promising candidate, which has previously been shown to confer protection in the small animal model, is a modified vaccinia ankara virus vector expressing the cchf viral glycoprotein (mva-gp). it has been shown that mva-gp induces both humoral and cellular immunogenicity. in t ... | 2016 | 27272940 |
| hyalomma ticks on northward migrating birds in southern spain: implications for the risk of entry of crimean-congo haemorrhagic fever virus to great britain. | crimean-congo haemorrhagic fever virus (cchfv) is a zoonotic virus transmitted by hyalomma ticks, the immature stages of which may be carried by migratory birds. in this study, a total of 12 hyalomma ticks were recovered from five of 228 migratory birds trapped in spring, 2012 in southern spain along the east atlantic flyway. all collected ticks tested negative for cchfv. while most birds had zero hyalomma ticks, two individuals had four and five ticks each and the statistical distribution of hy ... | 2016 | 27232135 |
| evidence for widespread infection of african bats with crimean-congo hemorrhagic fever-like viruses. | crimean congo hemorrhagic fever virus (cchfv) is a highly virulent tick-borne pathogen that causes hemorrhagic fever in humans. the geographic range of human cchf cases largely reflects the presence of ticks. however, highly similar cchfv lineages occur in geographically distant regions. tick-infested migratory birds have been suggested, but not confirmed, to contribute to the dispersal. bats have recently been shown to carry nairoviruses distinct from cchfv. in order to assess the presence of c ... | 2016 | 27217069 |
| molecular analysis of crimean-congo hemorrhagic fever virus and rickettsia in hyalomma marginatum ticks removed from patients (spain) and birds (spain and morocco), 2009-2015. | crimean-congo hemorrhagic fever virus (cchfv) was detected in spain in 2010. the presence of cchfv in hyalomma marginatum ticks from migratory birds passing through morocco during the spring migration strengthened the hypothesis of the arrival of infected ticks transported by birds to the iberian peninsula. furthermore, hyalomma species are vectors of bacterial infections such as spotted fever rickettsioses. cchfv and rickettsia were screened in hyalomma ticks from spain attached to patients (n= ... | 2016 | 27215620 |
| seroprevalence of crimean-congo hemorrhagic fever in turkey's van province. | crimean-congo hemorrhagic fever (cchf) is an endemic tick-borne viral disease that affects both animals and humans. this study aims to determine the seroprevalence of cchf in turkey's van province using analysis of blood samples obtained from people living in the region. blood specimens were taken from healthy subjects living in van province and some of the surrounding villages between january and july 2012. blood samples were initially tested using a cchf virus (cchfv) igm igg kit for anti-cchf ... | 2017 | 27169950 |