Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| evaluation of crimean-congo hemorrhagic fever virus in vitro inhibition by chloroquine and chlorpromazine, two fda approved molecules. | crimean-congo hemorrhagic virus (cchfv) causes hemorrhagic fever with high case mortality rates and is endemic in south-eastern europe, africa, and asia. the limited catalog of specific treatment, highlight the necessity to look for additional therapeutic solutions. previous experiments suggested that cchfv enters the cells via a clathrin dependent pathway. therefore, we have evaluated the potential anti-cchfv activity of several molecules targeting this entry possibility. we identified two mole ... | 2015 | 25796972 |
| a virus-like particle system identifies the endonuclease domain of crimean-congo hemorrhagic fever virus. | crimean-congo hemorrhagic fever virus (cchfv; genus nairovirus) is an extremely pathogenic member of the bunyaviridae family. since handling of the virus requires a biosafety level 4 (bsl-4) facility, little is known about pathomechanisms and host interactions. here, we describe the establishment of a transcriptionally competent virus-like particle (tc-vlp) system for cchfv. recombinant polymerase (l), nucleocapsid protein (n) and a reporter minigenome expressed in human huh-7 cells resulted in ... | 2015 | 25810550 |
| effect of tumour necrosis factor-alpha and interleukin-6 promoter polymorphisms on course of crimean-congo hemorrhagic fever in turkish patients. | in this case-control study, we investigated whether il-6 (-174g/c) and tnf-α (-308g/a) gene polymorphisms affect the clinical course and outcome of cchf. | 2015 | 25815864 |
| [crimean-congo hemorrhagic fever virus in stavropol region in 2011]. | the genetic analysis of the crimean-congo hemorrhagic fever (cchf) virus circulating in stavropol region during 2011 year was suggested. a total of 14 rna isolates from the crimean hemorrhagic fever patients were genetically typed. the genetic analysis of the cchf virus stains based on m-segment sequences (positions 2607-2932) supported the circulation of the genotype europe 1 in the stavropol region of russia. in addition to previously known lineage stv-ros, the second lineage vlg/ros was obser ... | 2014 | 25845138 |
| epidemiological survey of crimean congo hemorrhagic fever virus in cattle in east darfur state, sudan. | crimean-congo hemorrhagic fever (cchf) is a tick-borne disease caused by cchf virus (cchfv) of the genus nairovirus in the family bunyaviridae. cchfv causes subclinical infection in domestic livestock and an often fatal hemorrhagic illness in humans, with approximately 30% mortality rates. in the present study, a cross-sectional serosurvey was conducted in a total of 282 randomly selected cattle from five localities in east darfur state, sudan. the exposure status to cchf was determined using en ... | 2015 | 25898993 |
| antibodies to the core proteins of nairobi sheep disease virus/ganjam virus reveal details of the distribution of the proteins in infected cells and tissues. | nairobi sheep disease virus (nsdv; also called ganjam virus in india) is a bunyavirus of the genus nairovirus. it causes a haemorrhagic gastroenteritis in sheep and goats with mortality up to 90%. the virus is closely related to the human pathogen crimean-congo haemorrhagic fever virus (cchfv). little is currently known about the biology of nsdv. we have generated specific antibodies against the virus nucleocapsid protein (n) and polymerase (l) and used these to characterise nsdv in infected cel ... | 2015 | 25905707 |
| recovery of recombinant crimean congo hemorrhagic fever virus reveals a function for non-structural glycoproteins cleavage by furin. | crimean congo hemorrhagic fever virus (cchfv) is a negative-strand rna virus of the family bunyaviridae (genus: nairovirus). in humans, cchfv causes fever, hemorrhage, severe thrombocytopenia, and high fatality. a major impediment in precisely determining the basis of cchfv's high pathogenicity has been the lack of methodology to produce recombinant cchfv. we developed a reverse genetics system based on transfecting plasmids into bsr-t7/5 and huh7 cells. in our system, bacteriophage t7 rna polym ... | 2015 | 25933376 |
| cchf virus variants in pakistan and afghanistan: emerging diversity and epidemiology. | crimean congo hemorrhagic fever (cchf) has been reported from more than 30 countries in africa, asia, eastern europe and middle east. the disease is considered endemic in pakistan and neighboring countries like iran and afghanistan. | 2015 | 25959153 |
| a global compendium of human crimean-congo haemorrhagic fever virus occurrence. | in order to map global disease risk, a geographic database of human crimean-congo haemorrhagic fever virus (cchfv) occurrence was produced by surveying peer-reviewed literature and case reports, as well as informal online sources. here we present this database, comprising occurrence data linked to geographic point or polygon locations dating from 1953 to 2013. we fully describe all data collection, geo-positioning, database management and quality-control procedures. this is the most comprehensiv ... | 2015 | 25977820 |
| the global distribution of crimean-congo hemorrhagic fever. | crimean-congo hemorrhagic fever (cchf) is a tick-borne infection caused by a virus (cchfv) from the bunyaviridae family. domestic and wild vertebrates are asymptomatic reservoirs for the virus, putting animal handlers, slaughter-house workers and agricultural labourers at highest risk in endemic areas, with secondary transmission possible through contact with infected blood and other bodily fluids. human infection is characterized by severe symptoms that often result in death. while it is known ... | 2015 | 26142451 |
| fluorometric cchfv otu protease assay with potent inhibitors. | crimean-congo hemorrhagic fever virus (cchfv) is a deadly virus that has been listed in the category c as a potential bioterror agent. there are no specific therapies against cchfv, which urges identification of potential therapeutic targets and development of cchfv therapies. cchfv otu protease takes an important role in viral invasion through antagonizing nf-κb signaling. inhibition of cchfv otu protease by small molecules warrants an exciting potential as antiviral therapeutics. here we repor ... | 2015 | 26156848 |
| identifying main drivers and testing control strategies for cchfv spread. | crimean congo haemorrhagic fever (cchf) is an emerging zoonotic disease. the causative agent is a virus (cchfv), mainly transmitted by ticks of the species hyalomma marginatum in eastern europe and turkey. in order to test potential scenarios for the control of pathogen spread, the basic reproduction number (r0) for cchf was calculated. this calculation was based on a population dynamics model and parameter values from the literature for pathogen transmission. the tick population dynamics model ... | 2016 | 26174420 |
| crimean-congo haemorrhagic fever virus in kazakhstan (1948-2013). | crimean-congo haemorrhagic fever (cchf) is a pathogenic and often fatal arboviral disease with a distribution spanning large areas of africa, europe and asia. the causative agent is a negative-sense single-stranded rna virus classified within the nairovirus genus of the bunyaviridae family. cases of cchf have been officially recorded in kazakhstan since the disease was first officially reported in modern medicine. serological surveillance of human and animal populations provide evidence that the ... | 2015 | 26183415 |
| crimean-congo hemorrhagic fever. | crimean-congo hemorrhagic fever virus (cchfv) is a member of the bunyaviridae family and nairovirus genus. the viral genome consists of 3 rna segments of 12 kb (l), 6.8 kb (m), and 3 kb (s). crimean-congo hemorrhagic fever (cchf) is the most widespread tickborne viral infection worldwide: it has been reported in many regions of africa, the middle east, and asia. the geographical distribution of cchfv corresponds most closely with the distribution of members of the tick genera, and hyalomma ticks ... | 2015 | 26199256 |
| seroprevalence report on tick-borne encephalitis virus and crimean-congo hemorrhagic fever virus among malaysian's farm workers. | tick-borne encephalitis virus (tbev) and crimean-congo haemorrhagic fever virus (cchfv) are important tick-borne viruses. despite their wide geographical distribution and ease of acquisition, the prevalence of both viruses in malaysia is still unknown. this study was conducted to determine the seroprevalence for tbev and cchfv among malaysian farm workers as a high-risk group within the population. | 2015 | 26205588 |
| rig-i mediates an antiviral response to crimean-congo hemorrhagic fever virus. | in the cytoplasm, the retinoic acid-inducible gene i (rig-i) senses the rna genomes of several rna viruses. rig-i binds to viral rna, eliciting an antiviral response via the cellular adaptor mavs. crimean-congo hemorrhagic fever virus (cchfv), a negative-sense rna virus with a 5'-monophosphorylated genome, is a highly pathogenic zoonotic agent with significant public health implications. we found that, during cchfv infection, rig-i mediated a type i interferon (ifn) response via mavs. interferin ... | 2015 | 26223644 |
| structural and functional diversity of nairovirus-encoded nucleoproteins. | the nairoviruses include assorted tick-borne bunyaviruses that are emerging as causative agents of infectious diseases among humans and animals. as negative-sense single-stranded rna (-ssrna) viruses, nairoviruses encode nucleoprotein (np) that encapsidates the genomic rna and further forms ribonucleoprotein (rnp) complex with viral rna-dependent rna polymerase (rdrp). we previously revealed that the monomeric np encoded by crimean-congo hemorrhagic fever virus (cchfv) presents a racket-shaped s ... | 2015 | 26246561 |
| genomic characterization of yogue, kasokero, issyk-kul, keterah, gossas, and thiafora viruses: nairoviruses naturally infecting bats, shrews, and ticks. | the genus nairovirus of arthropod-borne bunyaviruses includes the important emerging human pathogen, crimean-congo hemorrhagic fever virus (cchfv), as well as nairobi sheep disease virus and many other poorly described viruses isolated from mammals, birds, and ticks. here, we report genome sequence analysis of six nairoviruses: thiafora virus (tfav) that was isolated from a shrew in senegal; yogue (yogv), kasokero (kkov), and gossas (gosv) viruses isolated from bats in senegal and uganda; issyk- ... | 2015 | 26324724 |
| crimean-congo hemorrhagic fever virus clade iv (asia 1) in ticks of western iran. | crimean-congo hemorrhagic fever virus (cchfv) is transmitted through the bite of an infected tick, or by direct contact with cchfv-infected patients' blood or the products of infected livestock. in 2012, ticks were collected in eight regions of lorestan province, iran. in total, 434 ticks were collected. reverse transcriptase polymerase chain reaction was used for the detection of cchfv rna. of 434 ticks, 419 (96.6%) ticks were from the family ixodidae (hard ticks) and 15 (3.5%) ticks were from ... | 2015 | 26336221 |
| a multiplex pcr/ldr assay for the simultaneous identification of category a infectious pathogens: agents of viral hemorrhagic fever and variola virus. | cdc designated category a infectious agents pose a major risk to national security and require special action for public health preparedness. they include viruses that cause viral hemorrhagic fever (vhf) syndrome as well as variola virus, the agent of smallpox. vhf is characterized by hemorrhage and fever with multi-organ failure leading to high morbidity and mortality. smallpox, a prior scourge, has been eradicated for decades, making it a particularly serious threat if released nefariously in ... | 2015 | 26381398 |
| cross-sectional serosurvey of crimean-congo hemorrhagic fever virus igg in livestock, india, 2013-2014. | we conducted a cross-sectional serosurvey of crimean-congo hemorrhagic fever (cchf) among livestock in 22 states and 1 union territory of india. a total of 5,636 samples from bovines, sheep, and goats were screened for cchf virus igg. igg was detected in 354 samples, indicating that this virus is widespread in this country. | 2015 | 26402332 |
| hospital-based surveillance for infectious etiologies among patients with acute febrile illness in georgia, 2008-2011. | information on the infectious causes of undifferentiated acute febrile illness (afi) in georgia is essential for effective treatment and prevention. in may 2008, a hospital-based afi surveillance was initiated at six hospitals in georgia. patients aged ≥ 4 years with fever ≥ 38°c for ≥ 48 hours were eligible for surveillance. blood culture and serologic testing were conducted for leptospira spp., brucella spp., west nile virus (wnv), crimean-congo hemorrhagic fever virus, coxiella burnetii, tick ... | 2016 | 26438032 |
| molecular epidemiology of crimean-congo hemorrhagic fever in bulgaria--an update. | crimean-congo hemorrhagic fever (cchf) is endemic in bulgaria. during 2013-2014, 11 confirmed cchf cases have been reported in the country (seven in 2013 and four in 2014). the present study provides the cchf molecular epidemiology in bulgaria based on all currently available s, m, and l rna segment nucleotide sequences spanning the years 1978-2014. a relatively low genetic difference (0-6%, the maximum seen in the m rna segment) was seen among the cchfv sequences suggesting that a slow evolving ... | 2016 | 26455333 |
| epidemiology, clinical and laboratory features of crimean-congo hemorrhagic fever in georgia. | crimean-congo hemorrhagic fever virus transmitted to humans by hyalomma ticks or by direct contact with the blood of infected humans or domestic animals. the most common clinical signs of cchf are fever, nausea, headache, diarrhea, myalgia, petechial rash, and bleeding. cchf is a severe disease in humans with a fatality rate up to 15-85%. this study was undertaken to determine the predictors of fatality among patients with cchf based on epidemiological, clinical, and laboratory findings. 34 pati ... | 2015 | 26483375 |
| the non-structural protein of crimean-congo hemorrhagic fever virus disrupts the mitochondrial membrane potential and induces apoptosis. | viruses have developed distinct strategies to overcome the host defense system. regulation of apoptosis in response to viral infection is important for virus survival and dissemination. like other viruses, crimean-congo hemorrhagic fever virus (cchfv) is known to regulate apoptosis. this study, for the first time, suggests that the non-structural protein nss of cchfv, a member of the genus nairovirus, induces apoptosis. in this report, we demonstrated the expression of cchfv nss, which contains ... | 2016 | 26574543 |
| vectors of crimean congo hemorrhagic fever virus in iran. | ticks are important vectors and reservoirs of crimean congo hemorrhagic fever (cchf) virus. human beings may be infected whenever the normal life cycle of the infected ticks on non-human vertebrate hosts is interrupted by the undesirable presence of humans in the cycle. a total of 26 species of argasid and ixodid ticks have been recorded in iran; including nine hyalomma, two rhipicephalus, two dermacentor, five haemaphysalis, two boophilus, one ixodes and two argas as well as three ornithodoros ... | 2015 | 26623426 |
| assessment of inhibitors of pathogenic crimean-congo hemorrhagic fever virus strains using virus-like particles. | crimean-congo hemorrhagic fever (cchf) is an often lethal, acute inflammatory illness that affects a large geographic area. the disease is caused by infection with cchf virus (cchfv), a nairovirus from the bunyaviridae family. basic research on cchfv has been severely hampered by biosafety requirements and lack of available strains and molecular tools. we report the development of a cchf transcription- and entry-competent virus-like particle (tecvlp) system that can be used to study cell entry a ... | 2015 | 26625182 |
| nairobi sheep disease virus/ganjam virus. | nairobi sheep disease virus (nsdv) is a tick-borne virus which causes a severe disease in sheep and goats, and has been responsible for several outbreaks of disease in east africa. the virus is also found in the indian subcontinent, where it is known as ganjam virus. the virus only spreads through the feeding of competent infected ticks, and is therefore limited in its geographic distribution by the distribution of those ticks, rhipicephalus appendiculata in africa and haemaphysalis intermedia i ... | 2015 | 26647464 |
| crimean-congo hemorrhagic fever virus subunit vaccines induce high levels of neutralizing antibodies but no protection in stat1 knockout mice. | crimean-congo hemorrhagic fever virus is a tick-borne bunyavirus of the nairovirus genus that causes hemorrhagic fever in humans with high case fatality. here, we report the development of subunit vaccines and their efficacy in signal transducer and activator of transcription 1 (stat1) knockout mice. ectodomains of the structural glycoproteins gn and gc were produced using a drosophila insect cell-based expression system. a single vaccination of stat129 mice with adjuvanted gn or gc ectodomains ... | 2015 | 26684523 |
| the prognostic significance of serum troponin t levels in crimean-congo hemorrhagic fever patients. | crimean-congo hemorrhagic fever (cchf) is a disease transmitted by the crimean-congo hemorrhagic fever virus (cchfv), characterized by severe fever and hemorrhage and with a reported fatality level of 3-30%. cerebral hemorrhage, gastrointestinal hemorrhage, severe anemia, shock, myocardial infarction, pulmonary edema, and pleural effusion may be seen as causes of death. cardiac troponin t (ctn-t) is a biochemical marker with high sensitivity and specificity in myocardial injury. the purpose of t ... | 2017 | 26693839 |
| sheep and goats as indicator animals for the circulation of cchfv in the environment. | crimean-congo hemorrhagic fever virus (cchfv) is a tick-borne virus, which causes a serious illness with case-fatality rates of up to 80% in humans. cchfv is endemic in many countries of africa, asia and southeastern europe. next to the countries with endemic areas, the distribution of cchfv is unknown in southeastern europe. as the antibody prevalence in animals is a good indicator for the presence or absence of the virus in a region, seroepidemiological studies can be used for the definition o ... | 2015 | 26704262 |
| the crystal structure of the hazara virus nucleocapsid protein. | hazara virus (hazv) is a member of the bunyaviridae family of segmented negative stranded rna viruses, and shares the same serogroup as crimean-congo haemorrhagic fever virus (cchfv). cchfv is responsible for fatal human disease with a mortality rate approaching 30 %, which has an increased recent incidence within southern europe. there are no preventative or therapeutic treatments for cchfv-mediated disease, and thus cchfv is classified as a hazard group 4 pathogen. in contrast hazv is not asso ... | 2015 | 26715309 |
| seroepidemiological studies of crimean-congo hemorrhagic fever virus in domestic and wild animals. | crimean-congo hemorrhagic fever (cchf) is a widely distributed, tick-borne viral disease. humans are the only species known to develop illness after cchf virus (cchfv) infection, characterized by a nonspecific febrile illness that can progress to severe, often fatal, hemorrhagic disease. a variety of animals may serve as asymptomatic reservoirs of cchfv in an endemic cycle of transmission. seroepidemiological studies have been instrumental in elucidating cchfv reservoirs and in determining endem ... | 2016 | 26741652 |
| molecular detection of crimean-congo haemorrhagic fever virus in ticks collected from infested livestock populations in a new endemic area, south of iran. | crimean-congo haemorrhagic fever (cchf) is a viral zoonotic disease with potentially fatal systemic effects on man. we aimed to determine the presence of cchf virus among collected ticks from domestic livestock from october 2012 to september 2013. | 2016 | 26758985 |
| seroprevalence of crimean-congo hemorrhagic fever virus in erzincan province, turkey, relationship with geographic features and risk factors. | to determine the seroprevalence and risk factors associated with crimean-congo hemorrhagic fever virus (cchfv) in residents of erzincan, turkey. although cchfv is endemic in erzincan, this is the first study to evaluate its seroprevalence in this region. this study included a total of 372 subjects, 174 of whom had been exposed to or bitten by ticks, 145 of whom worked with livestock, and 53 of whom resided in the city and did not have exposure to livestock. data on cchfv igg and igm antibodies w ... | 2016 | 26808904 |
| ap92-like crimean-congo hemorrhagic fever virus in hyalomma aegyptium ticks, algeria. | 0 | 26812469 | |
| vectorborne infections, mali. | 0 | 26812625 | |
| crimean-congo hemorrhagic fever virus gn bioinformatic analysis and construction of a recombinant bacmid in order to express gn by baculovirus expression system. | crimean-congo hemorrhagic fever virus (cchfv) is a member of the nairovirus, a genus in the bunyaviridae family, which causes a life threatening disease in human. currently, there is no vaccine against cchfv and detailed structural analysis of cchfv proteins remains undefined. the cchfv m rna segment encodes two viral surface glycoproteins known as gn and gc. viral glycoproteins can be considered as key targets for vaccine development. | 2015 | 26862379 |
| crimean-congo hemorrhagic fever: risk factors and control measures for the infection abatement. | crimean-congo hemorrhagic fever (cchf) is a vector-borne viral disease, widely distributed in different regions of the world. the fever is caused by the cchf virus (cchfv), which belongs to the nairovirus genus and bunyaviridae family. the virus is clustered in seven genotypes, which are africa-1, africa-2, africa-3, europe-1, europe-2, asia-1 and asia-2. the virus is highly pathogenic in nature, easily transmissible and has a high case fatality rate of 10-40%. the reservoir and vector of cchfv ... | 2016 | 26870327 |
| immunoinformatic analysis of crimean congo hemorrhagic fever virus glycoproteins and epitope prediction for synthetic peptide vaccine. | to determine the crimean congo hemorrhagic fever (cchf) virus m segement glycoprotein's immunoinformatic parameters, and identify human leukocyte antigen (hla) class i binders as candidates for synthetic peptide vaccines. | 2016 | 26876396 |
| the first fatal case of crimean-congo hemorrhagic fever caused by the ap92-like strain of the crimean-congo hemorrhagic fever virus. | 2016 | 26902209 | |
| analysis of the entry mechanism of crimean-congo hemorrhagic fever virus, using a vesicular stomatitis virus pseudotyping system. | crimean-congo hemorrhagic fever (cchf) is a tick-borne disease causing severe hemorrhagic symptoms with a nearly 30 % case-fatality rate in humans. the experimental use of cchf virus (cchfv), which causes cchf, requires high-biosafety-level (bsl) containment. in contrast, pseudotyping of various viral glycoproteins (gps) onto vesicular stomatitis virus (vsv) can be used in facilities with lower bsl containment, and this has facilitated studies on the viral entry mechanism and the measurement of ... | 2016 | 26935918 |
| sero-epidemiological survey of crimean-congo hemorrhagic fever virus in tunisia. | crimean-congo hemorrhagic fever (cchf) is a tick-borne disease associated with a high case fatality rate and transmitted mainly by hyalomma marginatum. the geographical distribution of h. marginatum covers most of the western mediterranean basin. we aimed to investigate whether cchf virus (cchfv) is circulating in tunisia. samples from unexplained acute febrile patients (n = 181) and a high risk group of humans, mainly slaughter workers (n = 38), were collected in the summer of 2014 and analyzed ... | 2016 | 26956221 |
| protective role of host aquaporin 6 against hazara virus, a model for crimean-congo hemorrhagic fever virus infection. | crimean-congo hemorrhagic fever virus (cchfv) is an arthropod-borne pathogen that causes infectious disease with severe hemorrhagic manifestations in vascular system in humans. the proper function of the cells in the vascular system is critically regulated by aquaporins (aqp), water channels that facilitate fluxes of water and small solutes across membranes. with hazara virus as a model for cchfv, we investigated the effects of viruses on aqp6 and the impact of aqp6 on virus infectivity in host ... | 2016 | 26976854 |
| current situation of crimean-congo hemorrhagic fever in southeastern europe and neighboring countries: a public health risk for the european union? | crimean-congo hemorrhagic fever (cchf) is the most widespread tick-borne viral infection of humans, occurring across western china through southern asia, middle east, and southeastern europe (see) and in the most of african countries. cchf virus is maintained through vertical and horizontal transmission in several genera of ticks, mainly in hyalomma, which spreads the virus to a variety of wild and domestic mammals, which develop a transient viremia without signs of illness. human infections occ ... | 2017 | 27044611 |
| assessment of recombination in the s-segment genome of crimean-congo hemorrhagic fever virus in iran. | crimean-congo hemorrhagic fever virus (cchfv) belongs to genus nairovirus and family bunyaviridae. the main aim of this study was to investigate the extent of recombination in s-segment genome of cchfv in iran. | 2016 | 27047968 |
| molecular epidemiology of crimean-congo hemorrhagic fever virus detected from ticks of one humped camels (camelus dromedarius) population in northeastern iran. | a comprehensive study was conducted on camel ticks to assess the epidemiological aspects of the infection in camels. from may 2012 to january 2013, 11 cities and towns from the khorasan provinces, northeastern iran, were randomly selected as a "cluster" and at least 14 camels were sampled from each cluster. a total of 200 camels were examined in this study, reverse transcriptase polymerase chain reaction was used for the detection of the crimean-congo hemorrhagic fever virus (cchfv) genome. tick ... | 2016 | 27065608 |
| crimean-congo hemorrhagic fever virus igg in goats, bhutan. | 2016 | 27088568 | |
| novel, in-house, sybr green based one-step rrt-pcr: rapid and accurate diagnosis of crimean-congo hemorrhagic fever virus in suspected patients from iran. | the crimean-congo hemorrhagic fever (cchf) virus causes severe disease in humans, with a high mortality rate. since, there is no approved vaccine or specific treatment for cchf, an early and accurate diagnosis, as well as reliable surveillance, is essential for case management and patient improvement. | 2016 | 27099688 |
| molecular insights into crimean-congo hemorrhagic fever virus. | crimean-congo hemorrhagic fever virus (cchfv) is a tick-borne pathogen that causes high morbidity and mortality. efficacy of vaccines and antivirals to treat human cchfv infections remains limited and controversial. research into pathology and underlying molecular mechanisms of cchfv and other nairoviruses is limited. significant progress has been made in our understanding of cchfv replication and pathogenesis in the past decade. here we review the most recent molecular advances in cchfv-related ... | 2016 | 27110812 |
| historical perspective: what constitutes discovery (of a new virus)? | a historic review of the discovery of new viruses leads to reminders of traditions that have evolved over 118 years. one such tradition gives credit for the discovery of a virus to the investigator(s) who not only carried out the seminal experiments but also correctly interpreted the findings (within the technological context of the day). early on, ultrafiltration played a unique role in "proving" that an infectious agent was a virus, as did a failure to find any microscopically visible agent, f ... | 2016 | 27112283 |
| seroprevalence of crimean-congo hemorrhagic fever in turkey's van province. | crimean-congo hemorrhagic fever (cchf) is an endemic tick-borne viral disease that affects both animals and humans. this study aims to determine the seroprevalence of cchf in turkey's van province using analysis of blood samples obtained from people living in the region. blood specimens were taken from healthy subjects living in van province and some of the surrounding villages between january and july 2012. blood samples were initially tested using a cchf virus (cchfv) igm igg kit for anti-cchf ... | 2017 | 27169950 |
| molecular analysis of crimean-congo hemorrhagic fever virus and rickettsia in hyalomma marginatum ticks removed from patients (spain) and birds (spain and morocco), 2009-2015. | crimean-congo hemorrhagic fever virus (cchfv) was detected in spain in 2010. the presence of cchfv in hyalomma marginatum ticks from migratory birds passing through morocco during the spring migration strengthened the hypothesis of the arrival of infected ticks transported by birds to the iberian peninsula. furthermore, hyalomma species are vectors of bacterial infections such as spotted fever rickettsioses. cchfv and rickettsia were screened in hyalomma ticks from spain attached to patients (n= ... | 2016 | 27215620 |
| evidence for widespread infection of african bats with crimean-congo hemorrhagic fever-like viruses. | crimean congo hemorrhagic fever virus (cchfv) is a highly virulent tick-borne pathogen that causes hemorrhagic fever in humans. the geographic range of human cchf cases largely reflects the presence of ticks. however, highly similar cchfv lineages occur in geographically distant regions. tick-infested migratory birds have been suggested, but not confirmed, to contribute to the dispersal. bats have recently been shown to carry nairoviruses distinct from cchfv. in order to assess the presence of c ... | 2016 | 27217069 |
| hyalomma ticks on northward migrating birds in southern spain: implications for the risk of entry of crimean-congo haemorrhagic fever virus to great britain. | crimean-congo haemorrhagic fever virus (cchfv) is a zoonotic virus transmitted by hyalomma ticks, the immature stages of which may be carried by migratory birds. in this study, a total of 12 hyalomma ticks were recovered from five of 228 migratory birds trapped in spring, 2012 in southern spain along the east atlantic flyway. all collected ticks tested negative for cchfv. while most birds had zero hyalomma ticks, two individuals had four and five ticks each and the statistical distribution of hy ... | 2016 | 27232135 |
| protective effects of a modified vaccinia ankara-based vaccine candidate against crimean-congo haemorrhagic fever virus require both cellular and humoral responses. | crimean-congo haemorrhagic fever (cchf) is a severe tick-borne disease, endemic in many countries in africa, the middle east, eastern europe and asia. there is no approved vaccine currently available against cchf. the most promising candidate, which has previously been shown to confer protection in the small animal model, is a modified vaccinia ankara virus vector expressing the cchf viral glycoprotein (mva-gp). it has been shown that mva-gp induces both humoral and cellular immunogenicity. in t ... | 2016 | 27272940 |
| genetic diversity of crimean congo hemorrhagic fever virus strains from iran. | crimean congo hemorrhagic fever virus (cchfv) is a member of the bunyaviridae family and nairovirus genus. it has a negative-sense, single stranded rna genome approximately 19.2 kb, containing the small, medium, and large segments. cchfvs are relatively divergent in their genome sequence and grouped in seven distinct clades based on s-segment sequence analysis and six clades based on m-segment sequences. our aim was to obtain new insights into the molecular epidemiology of cchfv in iran. | 2016 | 27308271 |
| crimean-congo hemorrhagic fever in the one-humped camel (camelus dromedarius) in east and northeast of iran. | this comprehensive study was conducted on multi-purpose one-humped camel (camelus dromedarius) sera and ticks to assess the epidemiological aspects of the crimean-congo hemorrhagic fever virus (cchfv) in northeast iran. | 2016 | 27308275 |
| molecular assay on crimean congo hemorrhagic fever virus in ticks (ixodidae) collected from kermanshah province, western iran. | crimean-congo hemorrhagic fever (cchf) is a feverous and hemorrhagic disease endemic in some parts of iran and caused by an arbovirus related to bunyaviridae family and nairovirusgenus. the main virus reservoir in the nature is ticks, however small vertebrates and a wide range of domestic and wild animals are regarded as reservoir hosts. this study was conducted to determine the infection rate of cchf virus in hard ticks of sarpole-zahab county, kermanshah province, west of iran. | 2016 | 27308296 |
| crimean-congo hemorrhagic fever with acute subdural hematoma, mauritania, 2012. | 2016 | 27315138 | |
| taking forward a 'one health' approach for turning the tide against the middle east respiratory syndrome coronavirus and other zoonotic pathogens with epidemic potential. | the appearance of novel pathogens of humans with epidemic potential and high mortality rates have threatened global health security for centuries. over the past few decades new zoonotic infectious diseases of humans caused by pathogens arising from animal reservoirs have included west nile virus, yellow fever virus, ebola virus, nipah virus, lassa fever virus, hanta virus, dengue fever virus, rift valley fever virus, crimean-congo haemorrhagic fever virus, severe acute respiratory syndrome coron ... | 2016 | 27321961 |
| hmgb1 is a potential biomarker for severe viral hemorrhagic fevers. | hemorrhagic fever with renal syndrome (hfrs) and crimean-congo hemorrhagic fever (cchf) are common representatives of viral hemorrhagic fevers still often neglected in some parts of the world. infection with dobrava or puumala virus (hfrs) and crimean-congo hemorrhagic fever virus (cchfv) can result in a mild, nonspecific febrile illness or as a severe disease with hemorrhaging and high fatality rate. an important factor in optimizing survival rate in patients with vhf is instant recognition of ... | 2016 | 27348219 |
| seroprevalence of west nile virus, crimean-congo hemorrhagic fever virus, francisella tularensis and borrelia burgdorferi in rural population of manisa, western turkey. | zoonotic diseases are well recognised threat to public health globally. the information of regional prevalence and associated risk factors allow the national programmes to determine and frame better strategies for their control, as they also provide the actual status of zoonosis in the region. the aim of this study was to determine the seroprevalence of west nile virus (wnv), crimean-congo hemorrhagic fever virus (cchfv), francisella tularensis and borrelia burgdorferi among the rural residents ... | 2017 | 27353580 |
| crimean-congo hemorrhagic fever virus lineages europe 1 and europe 2 in bulgarian ticks. | crimean-congo hemorrhagic fever (cchf) is a tick-borne human viral disease with fatality rate up to 30%. two genetic lineages of cchf virus (cchfv) are present in europe - lineage europe 1 which contains pathogenic cchfv strains, and lineage europe 2 consisting of ap92 and ap92-like strains. in order to investigate cchfv distribution and potential risk for humans, ticks were collected from livestock in the five districts where cchf cases have been reported in the last five years in bulgaria. cch ... | 2016 | 27378409 |
| crimean-congo hemorrhagic fever virus in livestock ticks and animal handler seroprevalence at an abattoir in ghana. | crimean-congo haemorrhagic fever virus (cchfv) is a zoonotic virus transmitted by ixodid ticks and causes crimean-congo hemorrhagic fever (cchf) disease in humans with up to 50 % mortality rate. | 2016 | 27392037 |
| biochemical and structural insights into the preference of nairoviral deisgylases for interferon-stimulated gene product 15 originating from certain species. | the regulation of the interferon type i (ifn-i) response has been shown to rely on posttranslational modification by ubiquitin (ub) and ub-like interferon-stimulated gene product 15 (isg15) to stabilize, or activate, a variety of ifn-i signaling and downstream effector proteins. unlike ub, which is almost perfectly conserved among eukaryotes, isg15 is highly divergent, even among mammals. since zoonotic viruses rely on viral proteins to recognize, or cleave, isg15 conjugates in order to evade, o ... | 2016 | 27412597 |
| occurrence of hyalomma, (acari: ixodidae) koch, 1844 on domestic animal in the union territory of dadra & nagar haveli, indian. | in response to recent outbreak of crimean-congo hemorrhagic fever (cchf) in gujarat (india). this investigation was carried out in order to determine the risk of cchf. the prevalence and abundance of hyalomma (acari: ixodidae) were recorded on the domestic animals in the union territory of dadra & nagar haveli during the period of january to december 2012. overall, 71 larva and 148 adults belonging to three species of hyalomma viz., hyal. anatolicum anatolicum, hyal. detritum, and hyal. marginat ... | 2016 | 27413337 |
| crimean-congo hemorrhagic fever virus in bulgaria and turkey. | infections of humans with the tick-borne crimean-congo hemorrhagic fever virus (cchfv) can cause a severe hemorrhagic fever with case fatality rates of up to 80%. most humans are infected by tick bite, crushing infected ticks by hand or by unprotected contact with blood of viremic mammals. next to the notified human cchf cases, the real distribution and the situation in animals in southeastern europe are nearly unknown. since domestic ruminants play a crucial role in the life cycle of the vector ... | 2016 | 27467142 |
| plant-produced crimean-congo haemorrhagic fever virus nucleoprotein for use in indirect elisa. | crimean-congo haemorrhagic fever (cchf) is a disease of serious public concern caused by the cchf virus (cchfv). anti-cchfv igg in humans can be detected using elisa with native antigen prepared from cell cultures which have been infected with virus or from brain tissue of suckling mice which have been inoculated with virus. however, the preparation of these reagents requires high biosafety levels and is expensive. a safer, more cost-effective recombinantly-produced np reagent is desirable. rece ... | 2016 | 27474493 |
| phylogeny of tick-derived crimean-congo hemorrhagic fever virus strains in iran. | the presence of crimean-congo hemorrhagic fever virus (cchfv) in iran was assessed by collecting ticks from golpayegan, isfahan province. real time rt-pcr was used to detect the cchfv rna in the tick population and the origins of the viral sequences were determined. the cchfv rna was detected in 5.2% of 492 ticks collected from livestock in different regions of golpayegan. the tick species that tested positive for the presence of cchfv rna included hyalomma, rhipicephalus and haemaphysalis speci ... | 2016 | 27491289 |
| crimean congo hemorrhagic fever virus and alkhurma (alkhumra) virus in ticks in djibouti. | crimean congo hemorrhagic fever virus and alkhumra virus, not previously reported in djibouti, were detected among 141 (infection rate = 15.7 per 100, 95% ci: 13.4-18.1) tick pools from 81 (37%) cattle and 2 (infection rate = 0.2 per 100, 95% ci: 0.0-0.7) tick pools from 2 (1%) cattle, respectively, collected at an abattoir in 2010 and 2011. | 2016 | 27508862 |
| heat shock protein 70 family members interact with crimean-congo hemorrhagic fever virus and hazara virus nucleocapsid proteins and perform a functional role in the nairovirus replication cycle. | the nairovirus genus of the bunyaviridae family contains serious human and animal pathogens classified within multiple serogroups and species. of these serogroups, the crimean-congo hemorrhagic fever virus (cchfv) serogroup comprises sole members cchfv and hazara virus (hazv). cchfv is an emerging zoonotic virus that causes often-fatal hemorrhagic fever in infected humans for which preventative or therapeutic strategies are not available. in contrast, hazv is nonpathogenic to humans and thus rep ... | 2016 | 27512070 |
| companion animals as a source of viruses for human beings and food production animals. | companion animals comprise a wide variety of species, including dogs, cats, horses, ferrets, guinea pigs, reptiles, birds and ornamental fish, as well as food production animal species, such as domestic pigs, kept as companion animals. despite their prominent place in human society, little is known about the role of companion animals as sources of viruses for people and food production animals. therefore, we reviewed the literature for accounts of infections of companion animals by zoonotic viru ... | 2016 | 27522300 |
| molecular epidemiology of crimean-congo haemorrhagic fever virus in india. | crimean-congo haemorrhagic fever (cchf) is an emerging zoonotic disease in india which is prevalent in neighbouring countries. cchf virus (cchfv) is a widespread tick-borne virus which is endemic in africa, asia, eastern europe and the middle east. in the present study, samples of clinically suspected human cases from different areas of northern-western india were tested for the presence of cchfv by rt-pcr through amplification of nucleocapsid (n) gene of cchfv. positive samples were sequenced t ... | 2016 | 27523802 |
| transmission and evolution of tick-borne viruses. | ticks transmit a diverse array of viruses such as tick-borne encephalitis virus, powassan virus, and crimean-congo hemorrhagic fever virus that are reemerging in many parts of the world. most tick-borne viruses (tbvs) are rna viruses that replicate using error-prone polymerases and produce genetically diverse viral populations that facilitate their rapid evolution and adaptation to novel environments. this article reviews the mechanisms of virus transmission by tick vectors, the molecular evolut ... | 2016 | 27569396 |
| a competitive elisa for species-independent detection of crimean-congo hemorrhagic fever virus specific antibodies. | crimean-congo hemorrhagic fever virus (cchfv) circulates in many countries of asia, africa, and europe. cchfv can cause a severe hemorrhagic fever in humans with case-fatality rates of up to 80%. cchf is considered to be one of the major emerging diseases spreading to and within europe. ticks of the genus hyalomma function as vector as well as natural reservoir of cchfv. ticks feed on various domestic animals (e.g. cattle, sheep, goats) and on wildlife (e.g. hares, hedgehogs). those animal speci ... | 2016 | 27623345 |
| molecular basis for the formation of ribonucleoprotein complex of crimean-congo hemorrhagic fever virus. | negative-sense single-strand rna (-ssrna) viruses comprise a large family of pathogens that cause severe human infectious diseases. all -ssrna viruses encode a nucleocapsid protein (np) to encapsidate the viral genome, which, together with polymerase, forms a ribonucleoprotein complex (rnp) that is packaged into virions and acts as the template for viral replication and transcription. in our previous work, we solved the monomeric structure of np encoded by crimean-congo hemorrhagic fever virus ( ... | 2016 | 27666016 |
| biosafety standards for working with crimean-congo hemorrhagic fever virus. | in countries from which crimean-congo haemorrhagic fever (cchf) is absent, the causative virus, cchf virus (cchfv), is classified as a hazard group 4 agent and handled in containment level (cl)-4. in contrast, most endemic countries out of necessity have had to perform diagnostic tests under biosafety level (bsl)-2 or -3 conditions. in particular, turkey and several of the balkan countries have safely processed more than 100 000 samples over many years in bsl-2 laboratories. it is therefore advo ... | 2016 | 27667586 |
| ticks threatening lineage of anatolian wild sheep (ovis gmelinii anatolica) and determination of their tick-borne pathogens. | we aimed to determine the ticks of the anatolian wild sheep and to define their tick-borne pathogens while molecularly studying their relationships with those of the domestic sheep. furthermore, another aim of this study is to investigate tick paralysis resulting in the death of the anatolian wild sheep. ticks and blood samples were collected from the wild sheep whilst tick samples were also collected from hares, guinea fowls, chickens, and a turkey living in the anatolian wild sheep breeding ar ... | 2016 | 27692336 |
| a chronological review of experimental infection studies of the role of wild animals and livestock in the maintenance and transmission of crimean-congo hemorrhagic fever virus. | this article provides a definitive review of experimental studies of the role of wild animals and livestock in the maintenance and transmission of crimean-congo hemorrhagic fever virus (cchfv), the etiologic agent of crimean-congo hemorrhagic fever (cchf), beginning with the first recognized outbreak of the human disease in crimea in 1944. published reports by researchers in the former soviet union, bulgaria, south africa, and other countries where cchf has been observed show that cchfv is maint ... | 2016 | 27713073 |
| serosurveillance of viral pathogens circulating in west africa. | sub-saharan africa is home to a variety of pathogens, but disease surveillance and the healthcare infrastructure necessary for proper management and control are severely limited. lassa virus, the cause of lassa fever, a severe hemorrhagic fever in humans is endemic in west africa. in sierra leone at the kenema government hospital lassa diagnostic laboratory, up to 70 % of acute patient samples suspected of lassa fever test negative for lassa virus infection. this large amount of acute undiagnose ... | 2016 | 27716429 |
| transstadial transmission and long-term association of crimean-congo hemorrhagic fever virus in ticks shapes genome plasticity. | the trade-off hypothesis, the current paradigm of arbovirus evolution, proposes that cycling between vertebrate and invertebrate hosts presents significant constraints on genetic change of arboviruses. studying these constraints in mosquito-borne viruses has led to a new understanding of epizootics. the trade-off hypothesis is assumed to be applicable to tick-borne viruses too, although studies are lacking. tick-borne crimean-congo hemorrhagic fever virus (cchfv), a member of the family bunyavir ... | 2016 | 27775001 |
| include crimean-congo haemorrhagic fever virus prevention in pre-travel advice. | 2017 | 27794472 | |
| crimean-congo hemorrhagic fever among children in iran. | crimean-congo hemorrhagic fever (cchf) is a viral zoonotic disease which is endemic in iran. the etiological agent of cchf is an rna virus belonging to the genus nairovirus of the family bunyaviridae. cchf virus (cchfv) can be transmitted to humans through bites from infected ticks and direct contact with infected blood or tissues. although the disease has been observed in different age groups, the rate of disease is lower in children and elderly. this study was designed to characterize cchfv-in ... | 2017 | 27878461 |
| phylogeography of crimean congo hemorrhagic fever virus. | crimean congo hemorrhagic fever virus (cchfv) is one of the most severe viral zoonozes. it is prevalent throughout africa, asia and southern europe. limited availability of sequence data has hindered phylogeographic studies. the complete genomic sequence of all three segments of 14 crimean congo hemorrhagic fever virus strains isolated from 1958-2000 in russia, central asia and africa was identified. each genomic segment was independently subjected to continuous bayesian phylogeographic analysis ... | 2016 | 27880794 |
| serological and virological evidence of crimean-congo haemorrhagic fever virus circulation in the human population of borno state, northeastern nigeria. | despite several studies on the seroprevalence of antibodies against crimean-congo haemorrhagic fever virus (cchfv) from humans and cattle in nigeria, detailed investigation looking at igg and igm have not been reported. additionally, there have been no confirmed cases of human cchfv infection reported from nigeria. | 2016 | 27926935 |
| crimean-congo haemorrhagic fever virus and eid-ul-adha festival in pakistan. | 2016 | 27998596 | |
| crimean-congo hemorrhagic fever virus in pakistan. | the crimean-congo hemorrhagic fever is a zoonotic disease transmitted by ticks and is characterized by fever and bleeding. it was seen for the first time in the south of present day ukraine and thus named, crimean fever. 1 in 1956, the virus was isolated in a patient with similar symptoms residing in congo, kenya and the virus was named congo virus. the viruses causing these two diseases were the same and hence was termed crimean-congo hemorrhagic fever virus (cchfv). humans are the only known h ... | 2017 | 28124602 |
| immunization with dna plasmids coding for crimean-congo hemorrhagic fever virus capsid and envelope proteins and/or virus-like particles induces protection and survival in challenged mice. | crimean congo hemorrhagic fever virus (cchfv) is a bunyavirus causing severe hemorrhagic fever disease in humans, with high mortality rates. the requirement of high-containment laboratory and the lack of animal model hampered the study of the immune response and protection of vaccine candidates.using the recently developed interferon-alpha-receptor knock-out (ifnar -/-) mouse model, which replicates human disease, we investigated the immunogenicity and protection of two novel cchfv vaccine candi ... | 2017 | 28250124 |
| a new strain of crimean-congo hemorrhagic fever virus isolated from xinjiang, china. | crimean-congo hemorrhagic fever virus (cchfv) is a highly pathogenic tick-borne virus with a fatality rate of up to 50% in humans. cchfv is widely distributed in countries around the world. outbreaks of cchfv infection in humans have occurred in prior years in xinjiang province, china. epidemiological surveys have detected cchfv rna in ticks and animals; however, few isolates were identified. in this study, we identified and isolated a new cchfv strain from hyalomma asiaticum asiaticum ticks col ... | 2017 | 28251517 |
| current status of crimean-congo haemorrhagic fever in the world health organization eastern mediterranean region: issues, challenges, and future directions. | crimean-congo haemorrhagic fever (cchf) is the most widespread, tick-borne viral disease affecting humans. the disease is endemic in many regions, such as africa, asia, eastern and southern europe, and central asia. recently, the incidence of cchf has increased rapidly in the countries of the world health organization eastern mediterranean region (who emr), with sporadic human cases and outbreaks of cchf being reported from a number of countries in the region. despite the rapidly growing inciden ... | 2017 | 28259724 |
| detection of crimean-congo hemorrhagic fever virus-specific igg antibodies in ruminants residing in central and western macedonia, greece. | crimean-congo hemorrhagic fever virus (cchfv) is a tick-borne virus which causes lethal hemorrhagic fever in humans. although, several reports regarding cchfv antibody prevalence in humans exist in greece, information about the current distribution is limited. the aim of the present study is to investigate the prevalence of cchfv-specific igg antibodies in cattle and sheep in macedonia-greece. the samplings were performed during spring 2013, in 5 regional units of central macedonia (chalkidiki, ... | 2017 | 28286143 |
| antiviral activity of cationic amphiphilic drugs. | emerging and reemerging viral infections represent a major concern for human and veterinary public health and there is an urgent need for the development of broad-spectrum antivirals. areas covered: a recent strategy in antiviral research is based on the identification of molecules targeting host functions required for infection of multiple viruses. a number of fda-approved drugs used to treat several human diseases are cationic amphiphilic drugs (cads) that have the ability to accumulate inside ... | 2017 | 28286997 |
| molecular (ticks) and serological (humans) study of crimean-congo hemorrhagic fever virus in the iberian peninsula, 2013-2015. | crimean-congo hemorrhagic fever (cchf) is a viral disease, mainly transmitted through tick bite, of great importance in public health. in spain, crimean-congo hemorrhagic fever virus (cchfv) was detected for the first time in 2010 in hyalomma lusitanicum ticks collected from deer in cáceres. the aim of this study was to investigate the presence of cchfv in ticks from cáceres, and from other spanish areas, and to evaluate the presence of antibodies against the virus in individuals exposed to tick ... | 2017 | 28291670 |
| expression and characterization of codon-optimized crimean-congo hemorrhagic fever virus gn glycoprotein in insect cells. | crimean-congo hemorrhagic fever virus (cchfv) is a major cause of tick-borne viral hemorrhagic disease in the world. despite of its importance as a deadly pathogen, there is currently no licensed vaccine against cchf disease. the attachment glycoprotein of cchfv (gn) is a potentially important target for protective antiviral immune responses. to characterize the expression of recombinant cchfv gn in an insect-cell-based system, we developed a gene expression system expressing the full-length cod ... | 2017 | 28316015 |
| the reasons why pakistan might be at high risk of crimean congo haemorrhagic fever epidemic; a scoping review of the literature. | pakistan has faced a number of significant healthcare challenges over the past decade. in 2000, one of these events - a deadly epidemic of crimean congo haemorrhagic fever (cchf) - struck pakistan. the people of pakistan are at a very high risk of acquiring cchf, due to a number of factors which emerge from a scoping review of the literature. first, the underdeveloped healthcare system of the country is currently not prepared to cope with challenges of this nature. healthcare professionals and m ... | 2017 | 28335777 |
| crimean-congo hemorrhagic fever virus in ticks in turkey: a broad range tick surveillance study. | in turkey, crimean-congo hemorrhagic fever (cchf) outbreaks started in northern regions in 2002. human cases still continue to increase and the disease spreads in many other provinces of turkey. the ecological role of the vector tick species occurring in turkey is not certain exactly. therefore, we planned a broad range tick study in three different ecological and geographical areas extending from the west black sea regions down to the central anatolia. the aim of this study was to determine and ... | 2017 | 28433738 |
| crimean-congo hemorrhagic fever cases in the north of iran have three distinct origins. | an on-going surveillance program on crimean-congo haemorrhagic fever virus (cchfv) in iran has been launched since 2000. an outbreak of cchf occurred in northern iran between june and july 2015. three cases were involved in this outbreak. one patient died after admission to hospital, and the others were treated successfully. phylogenetic analysis showed that three sequences obtained from iranian patients grouped within clade iv (asia-1), clade v (europe) and clade vi (greece). the partial sequen ... | 2017 | 28466055 |
| detection of a novel putative phlebovirus and first isolation of dugbe virus from ticks in accra, ghana. | ticks are ectoparasites that transmit various types of human and animal pathogens. in particular, emerging and re-emerging diseases caused by tick-borne viruses are public health concerns around the world. however, in many countries of the sub-saharan african region, epidemiological information on tick-borne viral infections is limited, and their prevalence and distribution remain largely unknown. in this study, we conducted surveillance on ticks to detect medically important tick-borne bunyavir ... | 2017 | 28479064 |
| vector and serologic survey for crimean-congo hemorrhagic fever virus in poland. | in contrast to animals, crimean-congo hemorrhagic fever (cchf) causes a severe disease in humans with a high mortality rate. the etiological agent, cchf virus (cchfv), can be transmitted by argasid and ixodid ticks, but arachnids of the genus hyalomma, followed by rhipicephalus and dermacentor serve as the major vectors of this virus. the goal of the study was to assess the epidemiological situation of cchfv infection in cattle in south-east poland, and survey for potential tick vector species. ... | 2017 | 28514225 |